NR1I3 Gene

Aliases &
Descriptions
for NR1I3 gene

Previous GC identifers: GC01M158910 GC01M156931 GC01M157978 GC01M158416 GC01M158012 GC01M159466

Summaries
for NR1I3 gene

Genomic Views
for NR1I3 gene

NR1I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161199:  view genomic region     (about GC identifiers)

RefSeq DNA sequence:

NC_000001.10  NT_004487.19  

Proteins
for NR1I3 gene

PDB structure from and Proteopedia :

1XV9 (3D)    1XVP (3D)    

Post-translational modifications:

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	HuPro® and/or Recombinant Proteins from Abnova for NR1I3
	Origene Purified Recombinant Human Protein: NR1I3
	Novus Biologicals Proteins for NR1I3
	Browse Sino Biological Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

	Millipore Mono- and Polyclonal Antibodies for the study of NR1I3
	Sigma-Aldrich Antibodies for NR1I3
	R&D Systems Antibodies for NR1I3 (CAR/NR1I3)
	Monoclonal and Polyclonal Antibodies from Abnova (NR1I3)
	Browse Origene Antibodies
	Novus Biologicals Antibodies for NR1I3
	Browse antibodies at Epitomics

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for NR1I3 gene

ProtoNet protein and cluster: Q14994

Gene Function
for NR1I3 gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NR1I3)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 15): NR1I3 Origene shRNA RFP (see all 15): NR1I3 Origene basic RS shRNA (see all 15): NR1I3
		Applied Biosystems Silencer® siRNAs for NR1I3
		Sigma-Aldrich siRNA Panels and siRNA for NR1I3 Sigma-Aldrich shRNA Panels and shRNA for NR1I3 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 15): NR1I3 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 15): NR1I3 Origene untagged cDNA clones in CMV expression vector (see all 15): NR1I3
		Browse Sino Biological Human cDNA Clones

5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10 ):

Animal Models: 5 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Nr1i3):

Pathways & Interactions
for NR1I3 gene

1 Millipore Pathway for NR1I3

Selected targets of GCR-alpha

3 Sigma-Aldrich "Your Favorite Gene" Pathways for  NR1I3  (Your Favorite Gene powered by Ingenuity)

	LPS/IL-1 Mediated Inhibition of RXR Function
	PXR/RXR Activation
	Xenobiotic Metabolism Signaling

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

Drugs & Compounds
for NR1I3 gene

Transcripts
for NR1I3 gene

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NR1I3)
		Applied Biosystems Silencer® siRNAs:  NM_001077469  NM_001077470  NM_001077471  NM_001077472  NM_001077473  NM_001077474  NM_001077475  NM_001077476   NM_001077477  NM_001077478  NM_001077479  NM_001077480  NM_001077481  NM_001077482  NM_005122
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 15): NR1I3 Origene shRNA RFP (see all 15): NR1I3 Origene basic RS shRNA (see all 15): NR1I3
		Sigma-Aldrich siRNA Panels and siRNA for NR1I3 Sigma-Aldrich shRNA Panels and shRNA for NR1I3 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate NR1I3:

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 15): NR1I3 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 15): NR1I3 Origene untagged cDNA clones in CMV expression vector (see all 15): NR1I3

Primers:		Origene genome-wide validated SYBR primer pairs: NR1I3
		SABiosciences RT2 qPCR Primer Assay for NR1I3: PPH01278A

REFSEQ mRNAs for NR1I3 gene (15 alternative transcripts): 

Additional cDNA sequence: 

highest scoring ESTs for NR1I3:

Expression
for NR1I3 gene

NR1I3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NR1I3

¹  / ²  / ³

4 probe-sets matching NR1I3 gene

Expression variation in blood from EXPOLDB for NR1I3

Primers:		Origene genome-wide validated SYBR primer pairs: NR1I3
		SABiosciences RT2 qPCR Primer Assay for NR1I3: PPH01278A

Orthologs
for NR1I3 gene

Paralogs
for NR1I3 gene

Paralogs for NR1I3 gene

VDR²  PPARD²  NR1I2²  RARG²  PPARA²  THRB²  RARA²  NR1H4²  

RARB²  NR1D2²  RORA²  RORB²  RORC²  NR1D1²  PPARG²  NR1H2²  

THRA²  NR1H3²  

NR1I3 for paralogs           About GeneDecksing

Genomic Variants
for NR1I3 gene

Disorders & Mutations
for NR1I3 gene

10/67 Novoseek disease relationships for NR1I3 gene (see all 67 )

Medical News
for NR1I3 gene

Publications
for NR1I3 gene

• A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PubMed id 8114692)^{1, 2, 3, 4} Baes M.... Moore D.D. (1994)
• Expression of CAR splice variants in human tissues and their functional consequences. (PubMed id 15194709)^{1, 3, 7} Lamba J.K.... Schuetz E. (2004)
• A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. (PubMed id 15610735)^{1, 3, 4} Xu R.X....Moore J.T. (2004)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
• Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. (PubMed id 15618763)^{3, 4} Ikeda S.... Sawada J. (2003)
• The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. (PubMed id 12464260)^{1, 7} Yamamoto Y....Negishi M. (2003)
• Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. (PubMed id 11991950)^{1, 7} Drocourt L....Vilarem M.J. (2002)
• A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PubMed id 8603043)^{3, 4} Choi H.S....Moore D.D. (1996)
• Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. (PubMed id 12611900)^{1, 3} Maglich J.M....Moore J.T. (2003)
• Induction of bilirubin clearance by the constitutive androstane receptor (CAR). (PubMed id 12644704)^{1, 3} Huang W....Moore D.D. (2003)
• Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. (PubMed id 17596880)^{1, 3} Patel R.D....Perdew G.H. (2007)
• Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. (PubMed id 15272053)^{1, 3} Huang W....Moore D.D. (2004)
• Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. (PubMed id 18331826)^{1, 3} Osabe M....Miwa M. (2008)
• Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. (PubMed id 15563456)^{1, 3} Swales K....Negishi M. (2005)
• Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. (PubMed id 15382119)^{1, 3} Assenat E....Pascussi J.M. (2004)
• Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. (PubMed id 18303024)^{1, 3} Inoue K. and Negishi M. (2008)
• The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. (PubMed id 18305370)^{1, 3} Konno Y....Kodama S. (2008)
• Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. (PubMed id 12376703)^{1, 3} Zhang J....Moore D.D. (2002)
• PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (PubMed id 17876342)^{1, 3} Hor S.Y....Tan T. (2008)
• Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. (PubMed id 19034627)^{1, 3} Li L....Wang H. (2009)
• Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. (PubMed id 19302787)^{1, 3} Osabe M....Miwa M. (2009)
• Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3. (PubMed id 18713018)^{1, 3} Yun H.J....Seol W. (2008)
• The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). (PubMed id 15252010)^{1, 3} Burk O....Wojnowski L. (2004)
• Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. (PubMed id 12644700)^{1, 3} Xie W....Evans R.M. (2003)
• Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. (PubMed id 12114525)^{1, 3} Min G....Kemper J.K. (2002)
• Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. (PubMed id 9783588)³ Forman B.M....Moore D.D. (1998)
• Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. (PubMed id 9295294)³ Choi H.S....Moore D.D. (1997)
• Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7. (PubMed id 17341620)¹ Min G. (2006)
• Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. (PubMed id 11075820)¹ Kawamoto T....Negishi M. (2000)
• ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics. (PubMed id 17118917)¹ Finkelstein D....Schuetz E. (2006)
• CAR, the continuously advancing receptor, in drug metabolism and disease. (PubMed id 16101572)¹ Qatanani M. and Moore D.D. (2005)
• Species-specific responses of constitutively active r eceptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear transloc ation of CAR in marine teleost, scup (Stenotomus chrysops). (PubMed id 11976065)¹ Iwata H....Stegeman J.J. (year=2002;month=Apr;day=)
• Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates. (PubMed id 19428328)¹ Eveillard A....Pineau T. (2009)
• Effects of intrauterine undernutrition on the expression of CYP3A23/3A1, PXR, CAR and HNF4alpha in neonate rats. (PubMed id 19058292)¹ Ni S....Chen S. (2008)
• Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. (PubMed id 17223708)¹ Wright E....Fernandez E.J. (2007)
• DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. (PubMed id 17904175)¹ Li C.C....Chen H.W. (2007)
• trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. (PubMed id 16449384)¹ Slitt A.L....Klaassen C.D. (2006)
• Extracellular signal-regulated kinase is an endogenou s signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. (PubMed id 17314319)¹ Koike C....Negishi M. (year=2007;month=May;day=)
• CAR and PXR: xenosensors of endocrine disrupters? (PubMed id 16054614)¹ Kretschmer X.C. and Baldwin W.S. (2005)
• Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1. (PubMed id 11256950)¹ Muangmoonchai R....Shephard E.A. (2001)
• CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. (PubMed id 15986414)¹ Wagner M....Trauner M. (year=2005;month=Aug;day=)
• A traditional herbal medicine enhances bilirubin clea rance by activating the nuclear receptor CAR. (PubMed id 14702117)¹ Huang W....Moore D.D. (year=2004;month=Jan;day=)
• The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. (PubMed id 18492798)¹ Li L....Wang H. (2008)
• Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes. (PubMed id 16964586)¹ Dvorak Z....Modriansky M. (2007)
• Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). (PubMed id 15000748)¹ Bae Y....Kemper B. (2004)
• Pathophysiological factors affecting CAR gene expression. (PubMed id 14705859)¹ Pascussi J.M....Vilarem M.J. (2003)
• A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR). (PubMed id 11405283)¹ Honkakoski P....Urtti A. (2001)
• Octachlorostyrene induces cytochrome P450, UDP-glucur onosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and c onstitutive androstane receptor. (PubMed id 19525444)¹ Yanagiba Y....Nakajima T. (2009)
• Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. (PubMed id 18786598)¹ Nannelli A....Gervasi P.G. (2008)
• o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. (PubMed id 17984292)¹ Kiyosawa N....Zacharewski T.R. (2008)
• CAR and PXR: the xenobiotic-sensing receptors. (PubMed id 17284330)¹ Timsit Y.E. and Negishi M. (2007)
• Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU. (PubMed id 11113125)¹ Kim J....Kemper B. (2001)
• Perfluorocarboxylic acids induce cytochrome P450 enzy mes in mouse liver through activation of PPAR-alpha and CAR transcription facto rs. (PubMed id 18648086)¹ Cheng X. and Klaassen C.D. (year=2008;month=Nov;day=)
• Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. (PubMed id 19211671)¹ DeKeyser J.G....Omiecinski C.J. (2009)
• C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. (PubMed id 18798339)¹ Blanco-Bose W.E....Trumpp A. (2008)
• Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. (PubMed id 18159929)¹ Moreau A....Pascussi J.M. (2008)
• Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. (PubMed id 18332086)¹ Gupta A....Unadkat J.D. (2008)
• Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). (PubMed id 16684648)¹ Chang T.K. and Waxman D.J. (2006)
• Beyond CAR and PXR. (PubMed id 16101576)¹ Dixit S.G....Kim R.B. (2005)
• In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. (PubMed id 16039771)¹ Souidi M....Dublineau I. (2005)
• Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. (PubMed id 14573755)¹ Kobayashi K.... Negishi M. (2003)
• Drug-activated nuclear receptors CAR and PXR. (PubMed id 12822739)¹ Honkakoski P....Negishi M. (2003)
• A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. (PubMed id 12523656)¹ Ekins S....Schuetz E.G. (2002)
• Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. (PubMed id 11981033)¹ Moore L.B....Moore J.T. (2002)
• The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. (PubMed id 11319871)¹ Briscoe C....Firtel R.A. (2001)
• Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. (PubMed id 7876207)¹ Caterina M.J....Devreotes P.N. (1995)
• Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1. (PubMed id 8120068)¹ Hereld D....Devreotes P. (1994)
• Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HN F4alpha. (PubMed id 19467232)¹ Inoue K. and Negishi M. (year=2009;month=Jun;day=18)
• In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin. (PubMed id 16919048)¹ Simonsson U.S....Lang M.A. (year=2006;month=Sep;day=)
• The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstan e receptor. (PubMed id 12554751)¹ Andersin T....Carlberg C. (year=2003;month=Feb;day=)
• Activation of pregnane X receptor (PXR) and constitut ive androstane receptor (CAR) by herbal medicines. (PubMed id 19688601)¹ Chang T.K. (2009)
• Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. (PubMed id 18778245)¹ Finn R.D....Wolf C.R. (2009)
• Xenobiotic-Sensing Nuclear Receptors CAR and PXR as D rug Targets in Cholestatic Liver Disease. (PubMed id 19925451)¹ Kakizaki S....Mori M. (2009)
• New insights on the xenobiotic-sensing nuclear receptors in liver diseases--CAR and PXR--. (PubMed id 18781913)¹ Kakizaki S....Negishi M. (2008)
• Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. (PubMed id 16831563)¹ Windshugel B....Sippl W. (2007)
• Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. (PubMed id 17112801)¹ Oscarson M....Meyer U.A. (2006)
• [Role of PXR and CAR in cholestasis] (PubMed id 16565602)¹ Suh J.I. (2006)
• Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. (PubMed id 16623664)¹ Inoue K....Negishi M. (2006)
• Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. (PubMed id 16749864)¹ Al-Dosari M.S....Liu D. (2006)
• Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. (PubMed id 16635107)¹ Gillberg M....Friis C. (2006)
• Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica). (PubMed id 16929008)¹ Sakai H....Tanabe S. (2006)
• Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. (PubMed id 15581595)¹ Handschin C. and Meyer U.A. (2005)
• Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. (PubMed id 16025508)¹ Karpen S.J. (2005)
• CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs. (PubMed id 15769478)¹ Chirulli V....Gervasi P.G. (2005)
• Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity. (PubMed id 15616833)¹ Windshugel B....Sippl W. (2005)
• CAR: detailing new models. (PubMed id 15276713)¹ Goodwin B. and Moore J.T. (2004)
• Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure. (PubMed id 12710995)¹ Jacobs M.N....Lewis D.F. (2003)
• Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. (PubMed id 12021388)¹ Ueda A....Sueyoshi T. (2002)
• P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. (PubMed id 10462436)¹ Waxman D.J. (1999)
• Amiloride toxicity in the fission yeast Schizosacchar omyces pombe is released by thiamine and mutations in the thiamine-repressible gene car1. (PubMed id 8675019)¹ Niederberger C....Schweingruber M.E. (year=1996;month=May;day=24)
• The uremic toxin 3-indoxyl sulfate is a potent endoge nous agonist for the human aryl hydrocarbon receptor. (PubMed id 20000589)¹ Schroeder J.C....Perdew G.H. (year=2010;month=Jan;day=19)
• The nuclear receptor CAR is a regulator of thyroid ho rmone metabolism during caloric restriction. (PubMed id 15004031)¹ Maglich J.M....Moore J.T. (year=2004;month=May;day=7)
• The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. (PubMed id 11057673)¹ Wei P....Moore D.D. (year=2000;month=Oct;day=19)

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