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NR1I3 Gene

protein-coding   GIFtS: 63
GCID: GC01M161199

Nuclear Receptor Subfamily 1, Group I, Member 3

  See NR1I3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 1, Group I, Member 31 2     Constitutive Active Receptor2
Constitutive Androstane Receptor1 2 3     Constitutive Androstane Nuclear Receptor Variant 22
CAR2 3 5     Constitutive Androstane Nuclear Receptor Variant 32
Constitutive Activator Of Retinoid Response2 3     Constitutive Androstane Nuclear Receptor Variant 42
Constitutive Active Response2 3     Constitutive Androstane Nuclear Receptor Variant 52
Orphan Nuclear Receptor MB672 3     Nuclear Receptor Subfamily 1 Group I Member 32
MB672 5     Orphan Nuclear Hormone Receptor2
CAR12     

External Ids:    HGNC: 79691   Entrez Gene: 99702   Ensembl: ENSG000001432577   OMIM: 6038815   UniProtKB: Q149943   

Export aliases for NR1I3 gene to outside databases

Previous GC identifers: GC01M158910 GC01M156931 GC01M157978 GC01M158416 GC01M158012 GC01M159466 GC01M132556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR1I3 Gene:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and
endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and
regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as
cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively
active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in
translocation of this protein to the nucleus, where it activates or represses target gene transcription. These
ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NR1I3 Gene:
NR1I3 (nuclear receptor subfamily 1, group I, member 3) is a protein-coding gene. Diseases associated with NR1I3 include biliary tract disease, and acute porphyria. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic
acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element
module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

summary for NR1I3 Gene:
Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and
constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor
family. VDR is expressed in the intestine, thyroid and kidney.

Gene Wiki entry for NR1I3 (Constitutive androstane receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR1I3 gene promoter:
         AP-1   ATF-2   MEF-2   CRE-BP1   PPAR-alpha   CREB   MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR1I3 promoter sequence
   Search Chromatin IP Primers for NR1I3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR1I3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

NR1I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1I3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161199:  view genomic region     (about GC identifiers)

Start:
161,199,456 bp from pter      End:
161,208,092 bp from pter
Size:
8,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 1 group I member 3  
Size: 352 amino acids; 39942 Da
Subunit: Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly
interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity)
2 PDB 3D structures from and Proteopedia for NR1I3:
1XV9 (3D)        1XVP (3D)    
Secondary accessions: E9PGH6 E9PH10 E9PHN4 F1D8Q0 F1D8Q1 Q0VAC9 Q4U0F0 Q5VTW5 Q5VTW6 Q6GZ68
Q6GZ77 Q6GZ78 Q6GZ83 Q6GZ84 Q6GZ85 Q6GZ87
Alternative splicing: 11 isoforms:  Q14994-1   Q14994-2   Q14994-3   Q14994-4   Q14994-5   Q14994-6   Q14994-7   Q14994-8   
Q14994-9   Q14994-10   Q14994-11   

Explore the universe of human proteins at neXtProt for NR1I3: NX_Q14994

Explore proteomics data for NR1I3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR1I3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_001070937.1  NP_001070938.1  NP_001070939.1  NP_001070940.1  NP_001070941.1  NP_001070942.1  NP_001070943.1  NP_001070944.1  
    NP_001070945.1  NP_001070946.1  NP_001070947.1  NP_001070948.1  NP_001070949.1  NP_001070950.1  NP_005113.1  

    ENSEMBL proteins: 
     ENSP00000425417   ENSP00000356962   ENSP00000407446   ENSP00000406493   ENSP00000399361  
     ENSP00000412672   ENSP00000424934   ENSP00000423666   ENSP00000356961   ENSP00000424834  
     ENSP00000422982   ENSP00000424345   ENSP00000427175   ENSP00000421374   ENSP00000423007  
     ENSP00000425607   ENSP00000356960   ENSP00000426016   ENSP00000421588   ENSP00000425900  
     ENSP00000426292   ENSP00000427600   ENSP00000356963   ENSP00000356965   ENSP00000356958  
     ENSP00000423089   ENSP00000427034   ENSP00000356959  
    Reactome Protein details: Q14994

    NR1I3 Human Recombinant Protein Products:

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    antibodies-online proteins for NR1I3 (7 products) 

     
    antibodies-online peptides for NR1I3

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    antibodies-online antibodies for NR1I3 (54 products) 

    NR1I3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Constitutive androstane receptor
    1I. Vitamin D receptor-like receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14994

    ProtoNet protein and cluster: Q14994

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
    Domain: Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization
    domains
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR1I3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR1I3_HUMAN, Q14994
    Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic
    acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element
    module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element
    Induction: By dexamethasone

         Genatlas biochemistry entry for NR1I3:
    nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several
    isoforms

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9783588
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8020947
    GO:0003707steroid hormone receptor activity ----
    GO:0003713transcription coactivator activity TAS9783588
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS8114692
         
    Find genes that share ontologies with NR1I3           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nr1i3):
     cellular  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with NR1I3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NR1I3: Nr1i3tm1.1Arte Nr1i3tm1Dgen

       genOway: Develop your customized and physiologically relevant rodent model for NR1I3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR1I3_HUMAN, Q14994: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7 (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with NR1I3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR1I3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Selected targets of GCR alpha
    Selected targets of GCR alpha
    4Nuclear receptors in lipid metabolism and toxicity
    Nuclear receptors in lipid metabolism and toxicity
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    Find genes that share SuperPaths with NR1I3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for NR1I3
        Nuclear Receptors
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway
    Glucocorticoid receptor regulatory network


    1 Reactome Pathway for NR1I3
        Nuclear Receptor transcription pathway

    1 PharmGKB Pathway for NR1I3
        Carbamazepine Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Array including NR1I3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR1I3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NR1I3 (Q149943 ENSP000003569594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    PPARGC1AQ9UBK23, ENSP000002648674I2D: score=1 STRING: ENSP00000264867
    RXRAP197933, ENSP000004196924I2D: score=2 STRING: ENSP00000419692
    NCOA1Q157883, ENSP000003209404I2D: score=2 STRING: ENSP00000320940
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS8020947
    GO:0010467gene expression TAS--

    Find genes that share ontologies with NR1I3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NR1I3
      Browse compounds at ApexBio 

    Compounds for NR1I3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    EB 1089Vitamin D receptor (VDR) agonist[134404-52-7]
    CalcipotriolVitamin D3 analog[112965-21-6]
    AlfacalcidolProdrug of vitamin D3 (Cat. No. 4156)[41294-56-8]
    CalcifediolProhormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D[19356-17-3]
    CalcitriolVitamin D receptor (VDR) agonist[32222-06-3]

    7 HMDB Compounds for NR1I3    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    2 DrugBank Compounds for NR1I3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5BETA)-PREGNANE-3,20-DIONE-- --target--10592235
    16,17-Androstene-3-Ol-- 7148-51-8target--10592235

    4 IUPHAR Ligands for NR1I3 (Constitutive androstane receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    CITCO
    AgonistAgonist7.312611900
    meclizine
    AntagonistAntagonist7.1615272053
    pregnanedione
    AgonistAgonist6.1710748001
    clotrimazole
    AntagonistAntagonist6.1610748001

    Selected Novoseek inferred chemical compound relationships for NR1I3 gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    androstane 99.2 707 11518807 (4), 12644700 (3), 16635107 (3), 11093784 (2) (see all 99)
    citco 97.5 23 19588937 (2), 16099843 (1), 16929008 (1), 18332083 (1) (see all 10)
    androstanol 91.6 12 15905360 (1), 16929008 (1), 17483497 (1), 18474683 (1) (see all 9)
    tcpobop 87.4 34 15563456 (4), 16101572 (3), 18798339 (3), 18441373 (2) (see all 10)
    androstenol 85 8 11457660 (3), 16929008 (1), 12114525 (1), 9783588 (1) (see all 5)
    phenobarbital 82.5 133 19920082 (5), 10993889 (5), 17904175 (5), 11113125 (3) (see all 48)
    dmes 82.4 14 19034627 (2), 16918318 (1), 18537574 (1), 19695866 (1) (see all 5)
    cinacalcet 78.2 16 16189180 (4), 14696958 (2), 15794735 (1), 17373205 (1) (see all 7)
    rifampicin 73.7 31 18786598 (3), 15919766 (3), 11181490 (2), 19588937 (2) (see all 16)
    metofluthrin 72.1 3 19378387 (1), 19176367 (1)



    Find genes that share compounds with NR1I3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NR1I3 gene (15 alternative transcripts): 
    NM_001077469.2  NM_001077470.2  NM_001077471.2  NM_001077472.2  NM_001077473.2  NM_001077474.2  NM_001077475.2  NM_001077476.2  
    NM_001077477.2  NM_001077478.2  NM_001077479.2  NM_001077480.2  NM_001077481.2  NM_001077482.2  NM_005122.4  

    Unigene Cluster for NR1I3:

    Nuclear receptor subfamily 1, group I, member 3
    Hs.349642  [show with all ESTs]
    Unigene Representative Sequence: AK303757
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000512372 ENST00000367983(uc001fzy.3) ENST00000488651 ENST00000464422
    ENST00000437437 ENST00000479324 ENST00000442691 ENST00000412844 ENST00000428574
    ENST00000505005 ENST00000508740 ENST00000367982 ENST00000506018 ENST00000508387
    ENST00000504010 ENST00000511676 ENST00000502985 ENST00000512340
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    Additional mRNA sequence: 

    AB307702.1 AK303757.1 AK303796.1 AK310773.1 AK316208.1 AY572806.1 AY572808.1 AY572810.1 
    AY572811.1 AY572812.1 AY572813.1 AY572816.1 AY572817.1 AY572818.1 AY572819.1 AY572820.1 
    AY572821.1 AY572822.1 AY572823.1 AY572824.1 AY572825.1 AY572827.1 BC069626.1 BC121120.1 
    BC121121.1 DQ022681.1 HQ692838.1 HQ692839.1 HQ692840.1 HQ692841.1 HQ709178.1 

    14 DOTS entries:

    DT.121424716  DT.118470  DT.95212776  DT.75101308  DT.121424516  DT.121424730  DT.121424744  DT.121424507 
    DT.121424513  DT.121424575  DT.91855775  DT.75170204  DT.91931603  DT.97809200 

    Selected AceView cDNA sequences (see all 70):

    AI262949 AY572825 AY572811 AY572816 BC069651 CB157668 AY572820 AW275372 
    AY572807 BM719939 AY572821 AY572818 AY572824 AV661397 AY572806 AY572815 
    AY572826 AY572810 AY572809 AY572819 AV652750 AV652691 AY572812 AY572823 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NR1I3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                              -           -         
    SP2:                                                  -                       -         
    SP3:                                                  -     -     -           -         
    SP4:        -     -                                                           -         
    SP5:        -     -                                   -                       -         


    ECgene alternative splicing isoforms for NR1I3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NR1I3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCTTCT
    NR1I3 Expression
    About this image


    NR1I3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Perivenous Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
    NR1I3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR1I3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.349642

    UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
    Tissue specificity: Predominantly expressed in liver

        Pathway & Disease-focused RT2 Profiler PCR Array including NR1I3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NR1I3
    OriGene qSTAR qPCR primer pairs in human, mouse for NR1I3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR1I3
    QuantiTect SYBR Green Assays in human, mouse, rat NR1I3
    QuantiFast Probe-based Assays in human, mouse, rat NR1I3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1I3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NR1I3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr1i31 , 5 nuclear receptor subfamily 1, group I, member 31, 5 80.75(n)1
    74.71(a)1
      1 (79.21 cM)5
    123551  NM_009803.51  NP_033933.21 
     1712139705 
    chicken
    (Gallus gallus)
    Aves NR1I31 nuclear receptor subfamily 1, group I, member 3 62.5(n)
    57.56(a)
      395439  NM_204702.1  NP_990033.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR1I36
    nuclear receptor subfamily 1, group I, member 3
    40(a)
    1 ↔ 1
    AAWZ02038821(3457-10280)
    fruit fly
    (Drosophila melanogaster)
    Insecta EcR6
    Ecdysone receptor
    12(a)
    1 → many
    2R(1975378-2056592)


    ENSEMBL Gene Tree for NR1I3 (if available)
    TreeFam Gene Tree for NR1I3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR1I3 gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    NR1D22  RARB2  RORA2  RORB2  RORC2  NR1D12  PPARG2  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for NR1I3 using alignment to 22 protein entries:     NR1I3_HUMAN (see all proteins) (see all similar genes):
    THRB    NR3C2    HNF4alpha    NR3C4    AR    VDR
    ESR2    NR5A2    ERRgamma    ESRRG    RXRB    NR3C1
    RORA    ESR1    NR1C3    NR4A1    PPARG    NR2A2

    Find genes that share paralogs with NR1I3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR1I3 (see all 364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999489711,2
    --132560554(+) ATATA-/TATG  
            
    TGTGT
    15 -- int10--------
    rs1121684381,2
    C,F--161202024(+) ACCCAG/CCTTGG 15 -- int11Minor allele frequency- C:0.50WA 2
    rs30035931,2
    C,H--161203627(+) TATAtA/Gtgtgt 15 -- int10--------
    rs112655691,2
    C,A,H--161203669(+) tgtgtA/Gtgtgt 15 -- int10--------
    rs124026561,2
    A,H--161203675(+) tgtgtA/GtGtat 15 -- int10--------
    rs1130937111,2
    C--161206516(+) TGTGG-/TTTTCT
            
    TTTTC
    15 -- cds11Minor allele frequency- TTTTCT:0.50CSA 2
    rs347950241,2
    C--161208668(+) AAAAAA/-GAGAG 15 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1117813521,2
    C,F--167695278(+) GCCCTC/TCTCAG 15 -- ds50013Minor allele frequency- T:0.14CSA WA 122
    rs1505439621,2
    C--167695425(+) CCCCCA/GGCACC 15 -- ds50010--------
    rs359371391,2
    C--167695639(-) GAAGCA/TCAGAA 15 -- ds50011Minor allele frequency- T:0.01--194

    HapMap Linkage Disequilibrium report for NR1I3 (161199456 - 161208092 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NR1I3: --
    Human Gene Mutation Database (HGMD): NR1I3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR1I3
    DNA2.0 Custom Variant and Variant Library Synthesis for NR1I3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603881    OMIM disorders: --

    10 diseases for NR1I3:    
    About MalaCards
    biliary tract disease    acute porphyria    familial hypocalciuric hypercalcemia    humoral hypercalcemia of malignancy
    uremia    primary hyperparathyroidism    intrahepatic cholestasis of pregnancy    hypercalcemia
    hyperparathyroidism    cholestasis

    3 diseases from the University of Copenhagen DISEASES database for NR1I3:
    Cholestasis     Bilirubin metabolic disorder     Neonatal jaundice

    Find genes that share disorders with NR1I3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NR1I3 gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperparathyroidism secondary 73.2 15 16189180 (2), 11033758 (1), 16919492 (1), 12830754 (1) (see all 13)
    nshpt 61.3 3 11033758 (1), 9507434 (1)
    hyperparathyroidism 60.1 11 15658669 (2), 8675635 (1), 17018434 (1), 9011580 (1) (see all 9)
    hypercalcemia 58.6 22 11033758 (2), 16189180 (2), 16603723 (2), 18492387 (1) (see all 9)
    hyperparathyroidism primary 57.2 11 11134144 (2), 16189180 (2), 8675635 (1), 9509247 (1) (see all 5)
    parathyroid hyperplasia 54.9 4 12469914 (2), 15888568 (1)
    cholestasis 54.4 8 16565602 (2), 16101572 (1), 19300246 (1), 16025508 (1) (see all 5)
    hypocalcemia 48.2 5 15507543 (1), 17018434 (1), 9757371 (1), 11701698 (1)
    hypoparathyroidism 43.9 10 11701698 (3), 12940896 (1), 9757371 (1), 9768650 (1) (see all 7)
    jaundice neonatal 43.5 3 12644704 (1), 19925451 (1)

    Genetic Association Database (GAD): NR1I3
    Human Genome Epidemiology (HuGE) Navigator: NR1I3 (7 documents)

    Export disorders for NR1I3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NR1I3 gene, integrated from 10 sources (see all 517) (see top 10):
    (articles sorted by number of sources associating them with NR1I3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PubMed id 8114692)1, 2, 3 Baes M.... Moore D.D. (Mol. Cell. Biol. 1994)
    2. Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PubMed id 19858220)1, 2, 9 Mutoh S.... Negishi M. (J. Biol. Chem. 2009)
    3. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PubMed id 15194709)1, 2, 9 Lamba J.K.... Schuetz E.G. (J. Pharmacol. Exp. Ther. 2004)
    4. PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (PubMed id 17876342)1, 4, 9 Hor S.Y....Tan T. (Pharmacogenomics J. 2008)
    5. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PubMed id 18056193)1, 4, 9 Tham L.S....Goh B.C. (Clin. Cancer Res. 2007)
    6. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. (PubMed id 15610735)1, 2, 9 Xu R.X....Moore J.T. (Mol. Cell 2004)
    7. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. (PubMed id 18294295)1, 4 Kiyotani K....Nakamura Y. (Cancer Sci. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. (PubMed id 15618763)1, 2 Ikeda S.... Sawada J. (Drug Metab. Pharmacokinet. 2003)
    10. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PubMed id 8603043)1, 2 Choi H.S.... Moore D.D. (J. Steroid Biochem. Mol. Biol. 1996)
    11. Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. (PubMed id 12114525)1, 9 Min G....Kemper J.K. (J. Biol. Chem. 2002)
    12. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). (PubMed id 12644704)1, 9 Huang W....Moore D.D. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    13. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. (PubMed id 17596880)1, 9 Patel R.D....Perdew G.H. (Hepatology 2007)
    14. Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density. (PubMed id 19702932)1, 9 Urano T....Inoue S. (amp 2009)
    15. Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. (PubMed id 18331826)1, 9 Osabe M....Miwa M. (Biochem. Biophys. Res. Commun. 2008)
    16. Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs. (PubMed id 15151997)1, 9 Frank C....Carlberg C. (J. Biol. Chem. 2004)
    17. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. (PubMed id 12551939)1, 9 Shiraki T....Jingami H. (J. Biol. Chem. 2003)
    18. Pharmacogenetics of the constitutive androstane receptor. (PubMed id 18154449)1, 9 Lamba J.K. (Pharmacogenomics 2008)
    19. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. (PubMed id 15272053)1, 9 Huang W....Moore D.D. (Mol. Endocrinol. 2004)
    20. Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. (PubMed id 12511605)1, 9 Pascussi J.M....Vilarem M.J. (Mol. Endocrinol. 2003)
    21. Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. (PubMed id 19302787)1, 9 Osabe M....Miwa M. (FEBS Lett. 2009)
    22. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. (PubMed id 18552123)1, 9 Surapureddi S....Goldstein J.A. (Mol. Pharmacol. 2008)
    23. Amino acids important for ligand specificity of the human constitutive androstane receptor. (PubMed id 15572376)1, 9 JyrkkAorinne J....Honkakoski P. (J. Biol. Chem. 2005)
    24. Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. (PubMed id 12485946)1, 9 Chang T.K....Chen J. (Drug Metab. Dispos. 2003)
    25. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. (PubMed id 12611900)1, 9 Maglich J.M....Moore J.T. (J. Biol. Chem. 2003)
    26. Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms. (PubMed id 17464991)1, 9 Pascussi J.M....Vilarem M.J. (Hepatology 2007)
    27. Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. (PubMed id 18303024)1, 9 Inoue K. and Negishi M. (J. Biol. Chem. 2008)
    28. The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. (PubMed id 18305370)1, 9 Konno Y....Kodama S. (Drug Metab. Pharmacokinet. 2008)
    29. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. (PubMed id 15919766)1, 9 Chen Y....Goldstein J.A. (J. Pharmacol. Exp. Ther. 2005)
    30. Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. (PubMed id 15563456)1, 9 Swales K....Negishi M. (J. Biol. Chem. 2005)
    31. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). (PubMed id 15252010)1, 9 Burk O....Wojnowski L. (J. Biol. Chem. 2004)
    32. Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (PubMed id 19682433)1, 9 Yoshinari K....Yamazoe Y. (Biochem. Pharmacol. 2010)
    33. Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers. (PubMed id 20218903)1, 9 Oliver P....Carcas A. (Clin. Chem. Lab. Med. 2010)
    34. Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor. (PubMed id 20197307)1, 9 Masuyama H....Hiramatsu Y. (Mol. Endocrinol. 2010)
    35. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. (PubMed id 19034627)1, 9 Li L....Wang H. (Pharm. Res. 2009)
    36. ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. (PubMed id 18332083)1, 9 Pascual M....Jover R. (Drug Metab. Dispos. 2008)
    37. Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. (PubMed id 17576804)1, 9 Wortham M....Wan Y.J. (Drug Metab. Dispos. 2007)
    38. Regulation of the human cathepsin E gene by the constitutive androstane receptor. (PubMed id 17888866)1, 9 Page J.L....Omiecinski C.J. (Arch. Biochem. Biophys. 2007)
    39. Alternative splicing within the ligand binding domain of the human constitutive androstane receptor. (PubMed id 14567971)1, 9 Savkur R.S....Burris T.P. (Mol. Genet. Metab. 2003)
    40. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. (PubMed id 12181452)1, 9 Ferguson S.S....Goldstein J.A. (Mol. Pharmacol. 2002)
    41. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. (PubMed id 11891224)1, 9 Gonzalez M.M. and Carlberg C. (J. Biol. Chem. 2002)
    42. Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1). (PubMed id 17276571)1, 9 Chen X....Chen G. (Toxicology 2007)
    43. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. (PubMed id 15933212)1, 9 Ferguson S.S....Goldstein J.A. (Mol. Pharmacol. 2005)
    44. Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. (PubMed id 15382119)1, 9 Assenat E....Pascussi J.M. (Hepatology 2004)
    45. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. (PubMed id 12644700)1, 9 Xie W....Evans R.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    46. Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor. (PubMed id 12896978)1, 9 Frank C....Carlberg C. (J. Biol. Chem. 2003)
    47. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. (PubMed id 9783588)1, 9 Forman B.M....Moore D.D. (Nature 1998)
    48. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. (PubMed id 24224465)1 Chen T....Omiecinski C.J. (Biochem. J. 2014)
    49. Gadd45 in the liver: signal transduction and transcriptional mechanisms. (PubMed id 24104474)1 Tian J. and Locker J. (Adv. Exp. Med. Biol. 2013)
    50. p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene. (PubMed id 23539296)1 Saito K....Negishi M. (Drug Metab. Dispos. 2013)
    51. Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor. (PubMed id 23172109)1 Cortes C.P....la Porte C.J. (Ther Drug Monit 2013)
    52. Expression of nuclear receptors (AhR, PXR, CAR) and transcription factor (Nrf2) in human parotid gland. (PubMed id 23614276)1 DroA_dzik A....Kurzawski M. (Acta Pol Pharm 2013)
    53. The time point of I^-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor. (PubMed id 23578392)1 Ganzenberg K....Braeuning A. (Toxicology 2013)
    54. PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms and lipid and lipoprotein levels in a Southern Brazilian population. (PubMed id 23079705)1 Lima L.O....Fiegenbaum M. (Mol. Biol. Rep. 2013)
    55. Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium. (PubMed id 23303387)1 Martino A....Canzian F. (J. Hum. Genet. 2013)
    56. MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. (PubMed id 22815988)1 Shizu R....Numazawa S. (PLoS ONE 2012)
    57. DP97, a DEAD box DNA/RNA helicase, is a target gene-selective co-regulator of the constitutive androstane receptor. (PubMed id 22910411)1 Kanno Y....Inouye Y. (Biochem. Biophys. Res. Commun. 2012)
    58. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). (PubMed id 22896671)1 Laurenzana E.M....Omiecinski C.J. (Mol. Pharmacol. 2012)
    59. Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. (PubMed id 22093699)1 Benoki S....Yamazoe Y. (Arch. Biochem. Biophys. 2012)
    60. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    61. Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. (PubMed id 21517853)1 Chan G.N....Bendayan R. (J. Neurochem. 2011)
    62. [Expression and clinical significance of constitutive androstane receptor in placental syntrophoblast of intrahepatic cholestasis of pregnancy]. (PubMed id 21733368)1 Sun X.M....Wu W.X. (Zhonghua Fu Chan Ke Za Zhi 2011)
    63. Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter. (PubMed id 21296199)1 Renga B....Fiorucci S. (Biochim. Biophys. Acta 2011)
    64. Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. (PubMed id 21715435)1 Wyen C....Owen A. (J. Antimicrob. Chemother. 2011)
    65. Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm. (PubMed id 21873423)1 Osabe M. and Negishi M. (J. Biol. Chem. 2011)
    66. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor. (PubMed id 21415305)1 Yueh M.F....Tukey R.H. (Mol. Pharmacol. 2011)
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    332. Extracellular calcium as an integrator of tissue function. (PubMed id 18328773)9 Breitwieser G.E. (amp 2008)
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    334. The nuclear hormone receptor family round the clock. (PubMed id 18653780)9 Teboul M....Delaunay F. (Mol. Endocrinol. 2008)
    335. Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. (PubMed id 18989830)9 Kenny J.R....Riley R. ( the fate of foreign compounds in biological systems 2008)
    336. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. (PubMed id 18342837)9 Dickmann L.J....Isoherranen N. (Biochem. Pharmacol. 2008)
    337. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. (PubMed id 18537574)9 Ma Q. and Lu A.Y. (Curr. Drug Metab. 2008)
    338. New insights on the xenobiotic-sensing nuclear receptors in liver diseases--CAR and PXR--. (PubMed id 18781913)9 Kakizaki S....Negishi M. (Curr. Drug Metab. 2008)
    339. Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. (PubMed id 18172616)9 Sugatani J....Miwa M. (Naunyn Schmiedebergs Arch. Pharmacol. 2008)
    340. Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. (PubMed id 18706437)9 Perez M.J....Marin J.J. (Toxicol. Appl. Pharmacol. 2008)
    341. Calcimimetics in CKD-results from recent clinical studies. (PubMed id 18594867)9 Schlieper G. and Floege J. (Pediatr. Nephrol. 2008)
    342. Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. (PubMed id 18037906)9 Martin P....Owen A. (Br. J. Pharmacol. 2008)
    343. CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. (PubMed id 18781911)9 Wang H. and Tompkins L.M. (Curr. Drug Metab. 2008)
    344. Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. (PubMed id 18686044)9 Sinz M....Sahi J. (AAPS J 2008)
    345. The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. (PubMed id 18362160)9 Yamamoto Y. and Negishi M. (Drug Metab. Dispos. 2008)
    346. Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. (PubMed id 18332078)9 Hariparsad N....Chu X. (Drug Metab. Dispos. 2008)
    347. Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. (PubMed id 18328680)9 Olinga P....Groothuis G.M. (Eur J Pharm Sci 2008)
    348. The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. (PubMed id 17608617)9 Pascussi J.M....Maurel P. (Annu. Rev. Pharmacol. Toxicol. 2008)
    349. Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. (PubMed id 17223708)9 Wright E....Fernandez E.J. (Biochemistry 2007)
    350. Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor. (PubMed id 17241389)9 Kakizaki S....Mori M. (Liver Int. 2007)
    351. Selected technologies to control genes and their products for experimental and clinical purposes. (PubMed id 17557142)9 Alexander H.K....Los M. (Arch. Immunol. Ther. Exp. (Warsz.) 2007)
    352. The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. (PubMed id 17451886)9 Harmsen S....Schellens J.H. (Cancer Treat. Rev. 2007)
    353. Mechanisms of cytochrome P450 induction. (PubMed id 17936931)9 Tompkins L.M. and Wallace A.D. (J. Biochem. Mol. Toxicol. 2007)
    354. Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. (PubMed id 16831563)9 WindshA1gel B....Sippl W. (amp 2007)
    355. Transcriptional regulation and expression of CYP3A4 in hepatocytes. (PubMed id 17305497)9 MartA-nez-JimAcnez C.P....GA^mez-LechA^n M.J. (Curr. Drug Metab. 2007)
    356. Clinical lessons from the calcium-sensing receptor. (PubMed id 17237839)9 Brown E.M. (amp 2007)
    357. Aromatic L-amino acids activate the calcium-sensing receptor. (PubMed id 17513419)9 Conigrave A.D....Lok H.C. (J. Nutr. 2007)
    358. CAR and PXR: the xenobiotic-sensing receptors. (PubMed id 17284330)9 Timsit Y.E. and Negishi M. (Steroids 2007)
    359. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. (PubMed id 17291602)9 Geier A....Trauner M. (Biochim. Biophys. Acta 2007)
    360. Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs. (PubMed id 16919959)9 Vaccarino A.L....Bazan N.G. (amp 2007)
    361. Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. (PubMed id 17979873)9 Hu J. and Spiegel A.M. (J. Cell. Mol. Med. 2007)
    362. Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). (PubMed id 17526421)9 Niimi S....Tanabe S. (amp 2007)
    363. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. (PubMed id 17442683)9 Urquhart B.L....Kim R.B. (J Clin Pharmacol 2007)
    364. Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes. (PubMed id 16964586)9 DvorA!k Z....ModrianskA1 M. (Cell Biol. Toxicol. 2007)
    365. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. (PubMed id 17637504)9 Westerink W.M. and Schoonen W.G. (Toxicol In Vitro 2007)
    366. Nuclear receptors in human immune cells: expression and correlations. (PubMed id 16837048)9 Schote A.B....Muller C.P. (Mol. Immunol. 2007)
    367. Pancreatitis in primary hyperparathyroidism-related hypercalcaemia is not associated with mutations in the CASR gene. (PubMed id 17853337)9 Felderbauer P....Schmidt W.E. (amp 2007)
    368. Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. (PubMed id 17696930)9 Zollner G....Trauner M. (Liver Int. 2007)
    369. Targeting farnesoid X receptor for liver and metabolic disorders. (PubMed id 17588816)9 Fiorucci S....Santucci L. (Trends Mol Med 2007)
    370. Genomic profiling in nuclear receptor-mediated toxicity. (PubMed id 17562482)9 Woods C.G....Rusyn I. (Toxicol Pathol 2007)
    371. Targeting carcinogen metabolism by dietary cancer preventive compounds. (PubMed id 17691900)9 Yu S. and Kong A.N. (Curr Cancer Drug Targets 2007)
    372. (Far) Outside the box: genomic approach to acute porphyria. (PubMed id 17298222)9 Thunell S. (Physiol Res 2006)
    373. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. (PubMed id 16837569)9 Jigorel E....Fardel O. (Drug Metab. Dispos. 2006)
    374. Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome. (PubMed id 17118915)9 Slatter J.G....Ulrich R.G. ( the fate of foreign compounds in biological systems 2006)
    375. Metabolic learning in the intestine: adaptation to nutrition and luminal factors. (PubMed id 16933181)9 Schmitz G. and Langmann T. (Horm. Metab. Res. 2006)
    376. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. (PubMed id 16557225)9 Bushinsky D.A....Asplin J.R. (Kidney Int. 2006)
    377. Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism. (PubMed id 16724929)9 Yamada H....Oguri K. (Curr. Drug Metab. 2006)
    378. Significance of the minor cytochrome P450 3A isoforms. (PubMed id 16430309)9 Daly A.K. (Clin Pharmacokinet 2006)
    379. Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7. (PubMed id 17341620)9 Min G. (Ann. N. Y. Acad. Sci. 2006)
    380. Parathyroid growth and suppression in renal failure. (PubMed id 16689976)9 Lewin E....Olgaard K. (Semin Dial 2006)
    381. Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. (PubMed id 16918318)9 Mandlekar S....Kong A.N. (Curr. Drug Metab. 2006)
    382. Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. (PubMed id 17112801)9 Oscarson M....Meyer U.A. (Clin. Pharmacol. Ther. 2006)
    383. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. (PubMed id 16291838)9 Levi R....Silver J. (J. Am. Soc. Nephrol. 2006)
    384. Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors. (PubMed id 16749854)9 Trottier J....Barbier O. (Mol. Pharm. 2006)
    385. NFAT regulates calcium-sensing receptor-mediated TNF production. (PubMed id 16380462)9 Abdullah H.I....Ferreri N.R. (Am. J. Physiol. Renal Physiol. 2006)
    386. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. (PubMed id 16204462)9 Aninat C....Guillouzo A. (Drug Metab. Dispos. 2006)
    387. Influence of parathyroid mass on the regulation of PTH secretion. (PubMed id 16810305)9 Lewin E. and Olgaard K. (Kidney Int. Suppl. 2006)
    388. Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. (PubMed id 16603723)9 Chattopadhyay N. (Am. J. Physiol. Endocrinol. Metab. 2006)
    389. Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. (PubMed id 16623664)9 Inoue K....Negishi M. (Biochem. J. 2006)
    390. AMSH regulates calcium-sensing receptor signaling through direct interactions. (PubMed id 16854379)9 Herrera-Vigenor F....Reyes-Cruz G. (Biochem. Biophys. Res. Commun. 2006)
    391. Herb-drug interactions in oncology: focus on mechanisms of induction. (PubMed id 16880233)9 Meijerman I....Schellens J.H. (Oncologist 2006)
    392. Cholestasis and cholestatic syndromes. (PubMed id 16550034)9 Rutherford A.E. and Pratt D.S. (Curr. Opin. Gastroenterol. 2006)
    393. Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). (PubMed id 16288980)9 Macchiarulo A....Pellicciari R. (amp 2006)
    394. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. (PubMed id 16608920)9 Duret C....Gerbal-Chaloin S. (Mol. Pharmacol. 2006)
    395. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. (PubMed id 16857725)9 Itoh M....Yokoi T. (J. Pharmacol. Exp. Ther. 2006)
    396. Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. (PubMed id 16101569)9 Zhou J....Xie W. (Curr. Drug Metab. 2005)
    397. Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism. (PubMed id 16189180)9 Kawata T....Nishizawa Y. (Eur. J. Endocrinol. 2005)
    398. Regulation of sulfotransferases by xenobiotic receptors. (PubMed id 16101570)9 Runge-Morris M. and Kocarek T.A. (Curr. Drug Metab. 2005)
    399. Animal models of xenobiotic receptors in drug metabolism and diseases. (PubMed id 16399373)9 Gong H....Xie W. (Meth. Enzymol. 2005)
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    401. Regulation of hepatic transporters by xenobiotic receptors. (PubMed id 16101571)9 Klaassen C.D. and Slitt A.L. (Curr. Drug Metab. 2005)
    402. Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. (PubMed id 16399349)9 Chatterjee B....Song C.S. (Meth. Enzymol. 2005)
    403. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. (PubMed id 15581595)9 Handschin C. and Meyer U.A. (Arch. Biochem. Biophys. 2005)
    404. Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. (PubMed id 16025508)9 Karpen S.J. (Hepatology 2005)
    405. Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells. (PubMed id 16188404)9 Malaplate-Armand C....Batt A.M. (Toxicol. Lett. 2005)
    406. Cinacalcet HCl: a novel therapeutic for hyperparathyroidism. (PubMed id 15794735)9 de Francisco A.L. (Expert Opin Pharmacother 2005)
    407. A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism. (PubMed id 15608136)9 Ekins S....Nikolskaya T. (Drug Metab. Dispos. 2005)
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    409. Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. (PubMed id 15557560)9 Sugatani J....Miwa M. (Mol. Pharmacol. 2005)
    410. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. (PubMed id 15905360)9 LempiAoinen H....Carlberg C. (Mol. Endocrinol. 2005)
    411. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. (PubMed id 15507543)9 Rodriguez M....Martin D. (Am. J. Physiol. Renal Physiol. 2005)
    412. Induction of phase I, II and III drug metabolism/transport by xenobiotics. (PubMed id 15832810)9 Xu C....Kong A.N. (Arch. Pharm. Res. 2005)
    413. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. (PubMed id 16166224)9 Rodriguez L....Chang W. (Endocrinology 2005)
    414. Regulation of CYP3A genes in the human respiratory tract. (PubMed id 15698577)9 Raunio H....Pelkonen O. (Chem. Biol. Interact. 2005)
    415. Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans. (PubMed id 15888568)9 CaA+adillas S....AlmadAcn Y. (J. Am. Soc. Nephrol. 2005)
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    418. Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. (PubMed id 15837785)9 Rey O....Rozengurt E. (J. Biol. Chem. 2005)
    419. Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. (PubMed id 15686947)9 Yang W....Dickson J.K. (amp 2005)
    420. Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor. (PubMed id 16399345)9 Sugatani J....Miwa M. (Meth. Enzymol. 2005)
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    423. Genetic variations and haplotypes of CYP2C19 in a Japanese population. (PubMed id 16141610)9 Fukushima-Uesaka H.... Sawada J. (Drug Metab. Pharmacokinet. 2005)
    424. Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. (PubMed id 16230703)9 KrA1ger K.A....Greger D.L. (J. Dairy Sci. 2005)
    425. Nuclear receptors and drug disposition gene regulation. (PubMed id 15858847)9 Tirona R.G. and Kim R.B. (J Pharm Sci 2005)
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    427. Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. (PubMed id 15888456)9 MolnA!r F....Carlberg C. (J. Biol. Chem. 2005)
    428. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. (PubMed id 16039771)9 Souidi M....Dublineau I. (Toxicology 2005)
    429. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. (PubMed id 16399343)9 Bock K.W. and KAPhle C. (Meth. Enzymol. 2005)
    430. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. (PubMed id 15849716)9 Smith C.M....LeCluyse E.L. (J. Biochem. Mol. Toxicol. 2005)
    431. Primary hyperparathyroidism. Update on pathophysiology, clinical presentation and surgical treatment. (PubMed id 15658669)9 Farnebo L.O. (Scand J Surg 2004)
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    433. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. (PubMed id 15104253)9 Sugatani J....Miwa M. (Biochem. Pharmacol. 2004)
    434. L-amino acids regulate parathyroid hormone secretion. (PubMed id 15234970)9 Conigrave A.D....Brown E.M. (J. Biol. Chem. 2004)
    435. Renal COX-2, cytokines and 20-HETE: tubular and vascular mechanisms. (PubMed id 14965324)9 Ferreri N.R....Quilley J. (Curr. Pharm. Des. 2004)
    436. Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). (PubMed id 15000748)9 Bae Y....Kemper B. (DNA Cell Biol. 2004)
    437. Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential. (PubMed id 14996618)9 Gong H. and Xie W. (Expert Opin. Ther. Targets 2004)
    438. Induction of cytochromes P450. (PubMed id 15579106)9 Dickins M. (Curr Top Med Chem 2004)
    439. Coordinate regulation of drug metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters. (PubMed id 15554238)9 Bock K.W. and KAPhle C. (Drug Metab. Rev. 2004)
    440. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (PubMed id 15004017)9 Assem M....Schuetz J.D. (J. Biol. Chem. 2004)
    441. CAR: detailing new models. (PubMed id 15276713)9 Goodwin B. and Moore J.T. (Trends Pharmacol. Sci. 2004)
    442. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? (PubMed id 15459087)9 Ory D.S. (Circ. Res. 2004)
    443. CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. (PubMed id 15578943)9 Luo G....Humphreys W.G. (Curr. Drug Metab. 2004)
    444. [Patomechanism of diabetic macroangiopathy. The role of calcium-sensing receptor (CaR)]. (PubMed id 15526852)9 MaA8ecki R. and Adamiec R. (Pol. Arch. Med. Wewn. 2004)
    445. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. (PubMed id 15051872)9 Dvorak M.M....Riccardi D. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    446. Clinical experience with cinacalcet HCl. (PubMed id 15284357)9 UreA+a Torres P. (Nephrol. Dial. Transplant. 2004)
    447. Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization. (PubMed id 14701866)9 Holstein D.M....Saunders C. (J. Biol. Chem. 2004)
    448. Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia. (PubMed id 14625199)9 Wang W....Nielsen S. (Am. J. Physiol. Renal Physiol. 2004)
    449. Evaluation of the toxicological relevance of CYP3A4 induction. (PubMed id 12613276)9 Plant N.J. and Gibson G.G. (amp 2003)
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    451. Repression of farnesoid X receptor during the acute phase response. (PubMed id 12519762)9 Kim M.S....Grunfeld C. (J. Biol. Chem. 2003)
    452. Transgenic mouse models of human CYP3A4 gene regulation. (PubMed id 12815159)9 Robertson G.R....Liddle C. (Mol. Pharmacol. 2003)
    453. Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery. (PubMed id 14575522)9 Maglich J.M....Moore J.T. (Am J Pharmacogenomics 2003)
    454. Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure. (PubMed id 12710995)9 Jacobs M.N....Lewis D.F. (J. Steroid Biochem. Mol. Biol. 2003)
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    456. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. (PubMed id 12695351)9 Wang H....LeCluyse E.L. (Drug Metab. Dispos. 2003)
    457. Nuclear receptors orchestrate detoxification pathways. (PubMed id 12737794)9 Roy-Chowdhury J....Roy-Chowdhury N. (Dev. Cell 2003)
    458. Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells. (PubMed id 12893520)9 Swales K....Gibson G. ( the fate of foreign compounds in biological systems 2003)
    459. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. (PubMed id 14671147)9 Shoback D.M....Peacock M. (J. Clin. Endocrinol. Metab. 2003)
    460. Vitamin D regulated keratinocyte differentiation: role of coactivators. (PubMed id 12520529)9 Bikle D.D....Oda Y. (J. Cell. Biochem. 2003)
    461. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. (PubMed id 14551287)9 Lamba V.... Schuetz E.G. (J. Pharmacol. Exp. Ther. 2003)
    462. Regulation of drug and bile salt transporters in liver and intestine. (PubMed id 14705863)9 Kullak-Ublick G.A. and Becker M.B. (Drug Metab. Rev. 2003)
    463. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. (PubMed id 12566446)9 Yueh M.F....Tukey R.H. (J. Biol. Chem. 2003)
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    466. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. (PubMed id 12573484)9 Pascussi J.M....Vilarem M.J. (Biochim. Biophys. Acta 2003)
    467. Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19. (PubMed id 12668916)9 Arefayene M....Flockhart D.A. (Pharmacogenetics 2003)
    468. Quantitation of CYP2B6, constitutive androstane receptor, and pregnane X receptor mRNA levels. (PubMed id 12718301)9 Hesse L.M. and Court M.H. (Drug Metab. Dispos. 2003)
    469. Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid. (PubMed id 12870655)9 Kawai M....Chang T.K. (Mol. Cell. Biochem. 2003)
    470. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1. (PubMed id 12130634)9 Aarnisalo P....Perlmann T. (J. Biol. Chem. 2002)
    471. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. (PubMed id 12369894)9 Rushmore T.H. and Kong A.N. (Curr. Drug Metab. 2002)
    472. Genomics and the prediction of xenobiotic toxicity. (PubMed id 12505353)9 Meyer U.A. and Gut J. (Toxicology 2002)
    473. The calcimimetic agents: perspectives for treatment. (PubMed id 11982829)9 FrazALo J.M....Coburn J.W. (Kidney Int. Suppl. 2002)
    474. Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. (PubMed id 12469914)9 Ritter C.S....Brown A.J. (J. Bone Miner. Res. 2002)
    475. Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C. (PubMed id 12356761)9 Young S.H....Rozengurt E. (J. Biol. Chem. 2002)
    476. L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? (PubMed id 12428172)9 Conigrave A.D....Quinn S.J. (Eur J Clin Nutr 2002)
    477. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). (PubMed id 12383267)9 Jensen A.A....BrAouner-Osborne H. (Eur. J. Biochem. 2002)
    478. Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. (PubMed id 12021388)9 Ueda A....Sueyoshi T. (Mol. Pharmacol. 2002)
    479. Regulation of hepatic drug metabolism: role of the nuclear receptors PXR and CAR. (PubMed id 12016543)9 Liddle C. and Goodwin B. (Semin. Liver Dis. 2002)
    480. Complexities of glucuronidation affecting in vitro in vivo extrapolation. (PubMed id 12369890)9 Lin J.H. and Wong B.K. (Curr. Drug Metab. 2002)
    481. [The role of nuclear receptors in cytochrome P-450 induction by xenochemicals]. (PubMed id 12664659)9 Palut D....StruciA8ski P. (Rocz Panstw Zakl Hig 2002)
    482. Insights from a three-dimensional model into ligand binding to constitutive active receptor. (PubMed id 12167558)9 Xiao L....Cheng K.C. (Drug Metab. Dispos. 2002)
    483. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. (PubMed id 12167569)9 El-Sankary W....Plant N. (Drug Metab. Dispos. 2002)
    484. [Calcimimetics as a new chance for effective treatment of calcium metabolism disturbances]. (PubMed id 12621766)9 Nowak Z. and LaudaA8ski K. (Pol. Merkur. Lekarski 2002)
    485. Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics. (PubMed id 11278292)9 Smirlis D....Shephard E.A. (J. Biol. Chem. 2001)
    486. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. (PubMed id 11560876)9 Drocourt L....Vilarem M.J. (Drug Metab. Dispos. 2001)
    487. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. (PubMed id 11264453)9 Sueyoshi T. and Negishi M. (Annu. Rev. Pharmacol. Toxicol. 2001)
    488. Prevention of uremic bone disease using calcimimetic compounds. (PubMed id 11160775)9 Olgaard K. and Lewin E. (Annu. Rev. Med. 2001)
    489. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. (PubMed id 11737189)9 Pascussi J.M....Vilarem M.J. (Eur. J. Biochem. 2001)
    490. Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism. (PubMed id 11589681)9 Yamauchi M....Chihara K. (Clin. Endocrinol. (Oxf) 2001)
    491. Activating mutations of the calcium-sensing receptor: management of hypocalcemia. (PubMed id 11701698)9 Lienhardt A....GarabAcdian M. (J. Clin. Endocrinol. Metab. 2001)
    492. Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism. (PubMed id 11703583)9 VAolimAoki S....Farnebo L.O. (Kidney Int. 2001)
    493. Comparative biosynthetic pathway of androstenol and androgens. (PubMed id 11457660)9 Dufort I....Luu-The V. (J. Steroid Biochem. Mol. Biol. 2001)
    494. Induction of CYP2C genes in human hepatocytes in primary culture. (PubMed id 11181490)9 Gerbal-Chaloin S....Maurel P. (Drug Metab. Dispos. 2001)
    495. First and second messenger role of calcium. Survival versus apoptosis in serum-free cultured granulosa explants. (PubMed id 11193025)9 Mussche S....D'Herde K. (Ann. N. Y. Acad. Sci. 2000)
    496. Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium. (PubMed id 11192933)9 Wang D....Ferreri N.R. (J. Physiol. Pharmacol. 2000)
    497. Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. (PubMed id 10885586)9 Fuhr U. (Clin Pharmacokinet 2000)
    498. Mutations in retinoid X receptor that impair heterodimerization with specific nuclear hormone receptor. (PubMed id 10948200)9 Lee S.K....Lee J.W. (J. Biol. Chem. 2000)
    499. Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. (PubMed id 11075820)9 Kawamoto T....Negishi M. (Mol. Endocrinol. 2000)
    500. Pathophysiology of primary hyperparathyroidism. (PubMed id 10809383)9 Hellman P....AkerstrAPm G. (Histol. Histopathol. 2000)
    501. The calcium receptor modulates the hyperpolarization-activated current in subfornical organ neurons. (PubMed id 11043554)9 Washburn D.L....Ferguson A.V. (Neuroreport 2000)
    502. The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis. (PubMed id 10940344)9 Brown E.M. (Annu. Rev. Nutr. 2000)
    503. Transcriptional control of hepatocanalicular transporter gene expression. (PubMed id 11076399)9 MA1ller M. (Semin. Liver Dis. 2000)

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    Entrez Gene: 9970 HGNC: 7969 AceView: NR1I3 Ensembl:ENSG00000143257 euGenes: HUgn9970
    ECgene: NR1I3 H-InvDB: NR1I3

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR1I3 Pharmacogenomics, SNPs, Pathways

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