NR1I3 Gene

Aliases
for NR1I3 gene

Previous GC identifers: GC01M158910 GC01M156931 GC01M157978 GC01M158416 GC01M158012 GC01M159466 GC01M132556

Summaries
for NR1I3 gene

Genomic Views
for NR1I3 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmid: NR1I3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1I3

NR1I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161199:  view genomic region     (about GC identifiers)

Proteins
for NR1I3 gene

2 PDB 3D structures from and Proteopedia for NR1I3:

1XV9 (3D)        1XVP (3D)    

Explore the universe of human proteins at neXtProt for NR1I3: NX_Q14994

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals NR1I3 Proteins Novus Biologicals NR1I3 Lysates
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	Uscn Proteins for NR1I3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

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	Uscn ELISAs and CLIAs for NR1I3

Protein Domains /
Families
for NR1I3 gene

ProtoNet protein and cluster: Q14994

Function
for NR1I3 gene

     Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

(inferred from 5 alleles) (MGI details for Nr1i3)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NR1I3

miRNA Products:		OriGene 3'-UTR Clone (see all 8): NR1I3 Browse MicroRNA Expression Plasmids
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1I3

Pathways & Interactions
for NR1I3 gene

	Super-pathway	contained gene-specific pathways
1	Nuclear Receptor transcription pathway	Nuclear Receptor transcription pathway 1.00 Nuclear Receptors 0.68
2	Generic Transcription Pathway	Generic Transcription Pathway 1.00 Gene Expression 0.46
3	Selected targets of GCR-alpha	Selected targets of GCR-alpha 1.00
4	Drug Induction of Bile Acid Pathway	Drug Induction of Bile Acid Pathway 1.00
5	Nuclear receptors in lipid metabolism and toxicity	Nuclear receptors in lipid metabolism and toxicity 1.00

1 EMD Millipore Pathway for NR1I3

Selected targets of GCR-alpha

4 BioSystems Pathways for NR1I3

	Nuclear Receptors
	Nuclear receptors in lipid metabolism and toxicity
	Drug Induction of Bile Acid Pathway
	Glucocorticoid receptor regulatory network

3        Reactome Pathways for NR1I3

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

1 PharmGKB Pathway for NR1I3

Carbamazepine Pathway, Pharmacokinetics

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for NR1I3 gene

Transcripts
for NR1I3 gene

Expression
for NR1I3 gene

NR1I3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTCTTCT

About this image

NR1I3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver LobulePerivenous Hepatocytes			Liver
	LiverLiver LobuleHepatocytes			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1I3

Orthologs
for NR1I3 gene

Paralogs
for NR1I3 gene

Paralogs for NR1I3 gene

VDR²  NR4A3²  NR4A1²  NR1I2²  RARG²  THRB²  RARA²  NR1H2²  

NR4A2²  NR1H4²  RARB²  THRA²  NR1H3²  

18/59 SIMAP similar genes for NR1I3 using alignment to 22 protein entries:     NR1I3_HUMAN (see all proteins) (see all similar genes):

THRB    NR3C2    HNF4alpha    NR3C4    AR    ESR2

NR5A2    VDR    ERRgamma    RXRB    ESRRG    PPARA

NR3C1    RORA    ESR1    NR1C3    NR4A1    PPARG

NR1I3 for paralogs           About GeneDecksing

Genomic Variants
for NR1I3 gene

10/291 NCBI SNPs in NR1I3 are shown (see all 291)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1117813521,2	C,F	--	132555956(+)	GCCCTC/TCTCAG	15	--	ds5001		3		CSA WA	122
rs359371391,2	C	--	132556317(-)	GAAGCA/TCAGAA	15	--	ds5001		1		--	194
rs23074171,2	C,F	--	132556358(-)	GGGGAA/TAGTGG	15	--	ds5001		1		NA	170
rs23074161,2	H	--	132556429(-)	GGCCGG/AGTTCA	22	/S /G	ut31 mis1 ese3		5		NA NS EA	582
rs38136291,2	H	--	132556446(+)	TTGGTC/TCCAGC	22	E G	ut31 mis1 ese3		4		NS EA	418
rs23074141,2	C,F,H	--	132556622(-)	TGCTAA/C/GGCCTG	31	S R G	mis1 int1		4		NA NS CSA	503
rs23074211,2	C,F,H	--	132556708(-)	TAGAGA/GCAAGA	15	--	int1		5		NA NS EA	582
rs351038721,2	C,F	--	132556709(-)	CTAGAG/AACAAG	15	--	int1		2		WA	312
rs348591881,2	C,F	--	132556733(-)	AGGAAT/CAGTTC	15	--	int1		2		WA	312
rs1124123661,2		--	132556820(+)	AGGGGG/TCCTCG	15	--	int1		1		CSA	2

HapMap Linkage Disequilibrium report for NR1I3 (161199456 - 161208092 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NR1I3: --
Human Gene Mutation Database (HGMD): NR1I3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR1I3

DNA2.0 Custom Variant and Variant Library Synthesis for NR1I3

Disorders / Diseases
for NR1I3 gene

20/55 diseases for NR1I3

10/39 Novoseek disease relationships for NR1I3 gene (see all 39)    About this table

Publications
for NR1I3 gene

PubMed articles for NR1I3 gene, integrated from 9 sources (see all 505) (see top 10): (articles sorted by number of sources associating them with NR1I3)

Utopia: connect your pdf to the dynamic world of online information

1. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PubMed id 8114692)^{1, 2, 3} Baes M.... Moore D.D. (1994)
2. Dephosphorylation of threonine 38 is required for nuc lear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PubMed id 19858220)^{1, 2, 9} Mutoh S....Negishi M. (2009)
3. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PubMed id 15194709)^{1, 2, 9} Lamba J.K.... Schuetz E.G. (2004)
4. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. (PubMed id 15610735)^{1, 2, 9} Xu R.X....Moore J.T. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. (PubMed id 15618763)^{1, 2} Ikeda S.... Sawada J. (2003)
7. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PubMed id 8603043)^{1, 2} Choi H.S.... Moore D.D. (1996)
8. Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. (PubMed id 12114525)^{1, 9} Min G....Kemper J.K. (2002)
9. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). (PubMed id 12644704)^{1, 9} Huang W....Moore D.D. (2003)
10. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. (PubMed id 17596880)^{1, 9} Patel R.D....Perdew G.H. (2007)
11. Association of a single nucleotide polymorphism in th e constitutive androstane receptor gene with bone mineral density. (PubMed id 19702932)^{1, 9} Urano T....Inoue S. (2009)
12. Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation. (PubMed id 18331826)^{1, 9} Osabe M....Miwa M. (2008)
13. Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs. (PubMed id 15151997)^{1, 9} Frank C....Carlberg C. (2004)
14. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. (PubMed id 12551939)^{1, 9} Shiraki T....Jingami H. (2003)
15. Pharmacogenetics of the constitutive androstane receptor. (PubMed id 18154449)^{1, 9} Lamba J.K. (2008)
16. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. (PubMed id 15272053)^{1, 9} Huang W....Moore D.D. (2004)
17. Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. (PubMed id 12511605)^{1, 9} Pascussi J.M....Vilarem M.J. (2003)
18. Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. (PubMed id 19302787)^{1, 9} Osabe M....Miwa M. (2009)
19. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. (PubMed id 18552123)^{1, 9} Surapureddi S....Goldstein J.A. (2008)
20. Amino acids important for ligand specificity of the human constitutive androstane receptor. (PubMed id 15572376)^{1, 9} Jyrkkarinne J....Honkakoski P. (2005)
21. Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. (PubMed id 12485946)^{1, 9} Chang T.K....Chen J. (2003)
22. Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. (PubMed id 12611900)^{1, 9} Maglich J.M....Moore J.T. (2003)
23. Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms. (PubMed id 17464991)^{1, 9} Pascussi J.M....Vilarem M.J. (2007)
24. PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (PubMed id 17876342)^{1, 9} Hor S.Y....Tan T. (2008)
25. Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. (PubMed id 18303024)^{1, 9} Inoue K. and Negishi M. (2008)
26. The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. (PubMed id 18305370)^{1, 9} Konno Y....Kodama S. (2008)
27. Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. (PubMed id 15563456)^{1, 9} Swales K....Negishi M. (2005)
28. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. (PubMed id 15919766)^{1, 9} Chen Y....Goldstein J.A. (2005)
29. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR). (PubMed id 15252010)^{1, 9} Burk O....Wojnowski L. (2004)
30. Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, preg nane/steroid X receptor and constitutive androstane receptor in 207 healthy Spa nish volunteers. (PubMed id 20218903)^{1, 9} Oliver P....Carcas A. (2010)
31. Constitutive androstane receptor transcriptionally ac tivates human CYP1A1 and CYP1A2 genes through a common regulatory element in th e 5'-flanking region. (PubMed id 19682433)^{1, 9} Yoshinari K....Yamazoe Y. (2010)
32. Effect of oncostatin M on uridine diphosphate-5'-gluc uronosyltransferase 1A1 through cross talk with constitutive androstane recepto r. (PubMed id 20197307)^{1, 9} Masuyama H....Hiramatsu Y. (2010)
33. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. (PubMed id 19034627)^{1, 9} Li L....Wang H. (2009)
34. ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. (PubMed id 18332083)^{1, 9} Pascual M....Jover R. (2008)
35. Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. (PubMed id 17576804)^{1, 9} Wortham M....Wan Y.J. (2007)
36. Regulation of the human cathepsin E gene by the constitutive androstane receptor. (PubMed id 17888866)^{1, 9} Page J.L....Omiecinski C.J. (2007)
37. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PubMed id 18056193)^{1, 9} Tham L.S....Goh B.C. (2007)
38. Alternative splicing within the ligand binding domain of the human constitutive androstane receptor. (PubMed id 14567971)^{1, 9} Savkur R.S....Burris T.P. (2003)
39. Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. (PubMed id 12181452)^{1, 9} Ferguson S.S....Goldstein J.A. (2002)
40. Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. (PubMed id 11891224)^{1, 9} Gonzalez M.M. and Carlberg C. (2002)
41. Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1). (PubMed id 17276571)^{1, 9} Chen X....Chen G. (2007)
42. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. (PubMed id 15933212)^{1, 9} Ferguson S.S....Goldstein J.A. (2005)
43. Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. (PubMed id 15382119)^{1, 9} Assenat E....Pascussi J.M. (2004)
44. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. (PubMed id 12644700)^{1, 9} Xie W....Evans R.M. (2003)
45. Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor. (PubMed id 12896978)^{1, 9} Frank C....Carlberg C. (2003)
46. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. (PubMed id 9783588)^{1, 9} Forman B.M....Moore D.D. (1998)
47. MicroRNA-122 down-regulation is involved in phenobarbi tal-mediated activation of the constitutive androstane receptor. (PubMed id 22815988)¹ Shizu R....Numazawa S. (2012)
48. DP97, a DEAD box DNA/RNA helicase, is a target gene-se lective co-regulator of the constitutive androstane receptor. (PubMed id 22910411)¹ Kanno Y....Inouye Y. (2012)
49. The orphan nuclear receptor DAX-1 functions as a poten t corepressor of the constitutive androstane receptor (NR1I3). (PubMed id 22896671)¹ Laurenzana E.M....Omiecinski C.J. (2012)
50. Transactivation of ABCG2 through a novel cis-element i n the distal promoter by constitutive androstane receptor but not pregnane X rec eptor in human hepatocytes. (PubMed id 22093699)¹ Benoki S....Yamazoe Y. (2012)
51. Regulation of P-glycoprotein by orphan nuclear recept ors in human brain microvessel endothelial cells. (PubMed id 21517853)¹ Chan G.N....Bendayan R. (2011)
52. Inhibition of human UGT2B7 gene expression in transge nic mice by the constitutive androstane receptor. (PubMed id 21415305)¹ Yueh M.F....Tukey R.H. (2011)
53. [Expression and clinical significance of constitutive androstane receptor in placental syntrophoblast of intrahepatic cholestasis of p regnancy]. (PubMed id 21733368)¹ Sun X.M....Wu W.X. (2011)
54. Farnesoid X receptor suppresses constitutive androsta ne receptor activity at the multidrug resistance protein-4 promoter. (PubMed id 21296199)¹ Renga B....Fiorucci S. (2011)
55. Cytochrome P450 2B6 (CYP2B6) and constitutive androst ane receptor (CAR) polymorphisms are associated with early discontinuation of e favirenz-containing regimens. (PubMed id 21715435)¹ Wyen C....Owen A. (2011)
56. Active ERK1/2 protein interacts with the phosphorylat ed nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dep hosphorylation and sequestering CAR in the cytoplasm. (PubMed id 21873423)¹ Osabe M. and Negishi M. (2011)
57. Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis. (PubMed id 21359593)¹ Chai J....Chen W. (2011)
58. Cigarette smoke extract induces CYP2B6 through consti tutive androstane receptor in hepatocytes. (PubMed id 20966044)¹ Washio I....Azuma J. (2011)
59. CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with co nstitutive androstane receptor to transactivate the human cytochrome P450 2B6 ( CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model. (PubMed id 20622021)¹ Benet M....Jover R. (2010)
60. PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor. (PubMed id 18202305)¹ Sueyoshi T....Negishi M. (2008)
61. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. (PubMed id 18294295)¹ Kiyotani K....Nakamura Y. (2008)
62. Specific inhibition of transcriptional activity of the constitutive androstane receptor (CAR) by the splicing factor SF3a3. (PubMed id 18713018)¹ Yun H.J....Seol W. (2008)
63. Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. (PubMed id 17962186)¹ Guo D....Reddy J.K. (2007)
64. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
65. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. (PubMed id 16554032)¹ Surapureddi S.... Reddy J.K. (2006)
66. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
67. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
68. Automated yeast two-hybrid screening for nuclear rece ptor-interacting proteins. (PubMed id 15604093)¹ Albers M....Koegl M. (2005)
69. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. (PubMed id 15831521)¹ Huang W....Moore D.D. (2005)
70. Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX -1. (PubMed id 14963109)¹ Park Y.Y....Choi H.S. (2004)
71. Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. (PubMed id 14573755)² Kobayashi K.... Negishi M. (2003)
72. Alternatively spliced isoforms of the human constitutive androstane receptor. (PubMed id 12799447)¹ Auerbach S.S....Omiecinski C.J. (2003)
73. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. (PubMed id 12130689)¹ Goodwin B....Liddle C. (2002)
74. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. (PubMed id 12376703)¹ Zhang J....Moore D.D. (2002)
75. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
76. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
77. Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). (PubMed id 9773978)¹ Seol W....Moore D.D. (1998)
78. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. (PubMed id 9295294)¹ Choi H.S....Moore D.D. (1997)
79. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. (PubMed id 8650544)¹ Seol W.... Moore D.D. (1996)
80. Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica). (PubMed id 16929008)⁹ Sakai H....Tanabe S. (2006)
81. High affinity interaction with filamin A protects against calcium-sensing receptor degradation. (PubMed id 15657061)⁹ Zhang M. and Breitwieser G.E. (2005)
82. Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. (PubMed id 16513638)⁹ Huang Y.... Breitwieser G.E. (2006)
83. CAR, the continuously advancing receptor, in drug metabolism and disease. (PubMed id 16101572)⁹ Qatanani M. and Moore D.D. (2005)
84. Enhanced expression of extracellular calcium sensing receptor in monocyte-differentiated versus undifferentiated HL-60 cells: potential role in regulation of a nonselective cation channel. (PubMed id 10773108)⁹ Yamaguchi T....Brown E.M. (2000)
85. Agonists of the Ca(2+)-sensing receptor (CaR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR. (PubMed id 8806675)⁹ Ye C....Vassilev P.M. (1996)
86. Dietary flavonoids activate the constitutive androsta ne receptor (CAR). (PubMed id 20099825)⁹ Yao R....Abe K. (2010)
87. Effects of intrauterine undernutrition on the expression of CYP3A23/3A1, PXR, CAR and HNF4alpha in neonate rats. (PubMed id 19058292)⁹ Ni S....Chen S. (2008)
88. Subcellular trafficking signals of constitutive androstane receptor: evidence for a nuclear export signal in the DNA-binding domain. (PubMed id 17567731)⁹ Xia J. and Kemper B. (2007)
89. The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. (PubMed id 17483497)⁹ Hernandez J.P....Baldwin W.S. (2007)
90. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. (PubMed id 17904175)⁹ Li C.C....Chen H.W. (2007)
91. Functional analysis of four naturally occurring variants of human constitutive androstane receptor. (PubMed id 15990349)⁹ Ikeda S....Sawada J. (2005)
92. Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). (PubMed id 20185760)⁹ Breuker C....Pascussi J.M. (2010)
93. Simultaneous changes in the calcium-sensing receptor and the vitamin D receptor under the influence of calcium and calcitriol. (PubMed id 18556746)⁹ Carrillo-Lopez N....Cannata-Andia J.B. (2008)
94. Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor. (PubMed id 17591676)⁹ Kohalmy K....Monostory K. (2007)
95. The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. (PubMed id 17531955)⁹ Chattopadhyay N....Brown E.M. (2007)
96. ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics. (PubMed id 17118917)⁹ Finkelstein D....Schuetz E. (2006)
97. CAR and PXR: xenosensors of endocrine disrupters? (PubMed id 16054614)⁹ Kretschmer X.C. and Baldwin W.S. (2005)
98. Identification of constitutive androstane receptor cDNA in northern fur seal (Callorhinus ursinus). (PubMed id 15178021)⁹ Sakai H....Baba N. (2004)
99. The calcium sensing receptor: from understanding parathyroid calcium homeostasis to bone metastases. (PubMed id 18492387)⁹ Mihai R. (2008)
100. Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship. (PubMed id 18983136)⁹ JyrkkAorinne J....Honkakoski P. (2008)
101. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. (PubMed id 18677425)⁹ Scheer N....Wolf C.R. (2008)
102. Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. (PubMed id 18441373)⁹ Masson D....Assem M. (2008)
103. Role of calcium-sensing receptor in bone biology. (PubMed id 18497443)⁹ Sharan K....Chattopadhyay N. (2008)
104. Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. (PubMed id 17284438)⁹ Huang Y. and Breitwieser G.E. (2007)
105. trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. (PubMed id 16449384)⁹ Slitt A.L....Klaassen C.D. (2006)
106. A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression. (PubMed id 16006237)⁹ Burk O....Eichelbaum M. (2005)
107. In vivo activation of the constitutive androstane receptor beta (CARbeta) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA-S). (PubMed id 12482595)⁹ Fujita A....Ohsawa N. (2002)
108. The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation. (PubMed id 12459170)⁹ Yamaguchi T....Chihara K. (2002)
109. The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium. (PubMed id 1537842)⁹ Johnson R.L....Devreotes P.N. (1992)
110. Characterization of the porcine constitutive androsta ne receptor (CAR) and its splice variants. (PubMed id 19925382)⁹ Gray M.A....Squires E.J. (2009)
111. PXR and CAR in energy metabolism. (PubMed id 19595610)⁹ Wada T....Xie W. (2009)
112. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. (PubMed id 18798339)⁹ Blanco-Bose W.E....Trumpp A. (2008)
113. Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis. (PubMed id 18973326)⁹ Repo S....Johnson M.S. (2008)
114. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor. (PubMed id 18786510)⁹ Kublbeck J....Windshugel B. (2008)
115. Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism. (PubMed id 17426287)⁹ Reyes-Ibarra A.P....Reyes-Cruz G. (2007)
116. Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. (PubMed id 16919492)⁹ Chattopadhyay N. and Brown E.M. (2006)
117. Calcium sensing receptors and calcium oscillations: calcium as a first messenger. (PubMed id 16782456)⁹ Breitwieser G.E. (2006)
118. Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. (PubMed id 16101575)⁹ Lamba J....Schuetz E. (2005)
119. Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons. (PubMed id 16197734)⁹ Thompson E.E....Di Rienzo A. (2005)
120. Pathophysiological factors affecting CAR gene expression. (PubMed id 14705859)⁹ Pascussi J.M....Vilarem M.J. (2003)
121. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. (PubMed id 11706036)⁹ Kast H.R....Edwards P.A. (2002)
122. Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor. (PubMed id 12220510)⁹ McLarnon S....Riccardi D. (2002)
123. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. (PubMed id 11390379)⁹ Awata H....Miller R.T. (2001)
124. L-amino acid sensing by the extracellular Ca2+-sensing receptor. (PubMed id 10781086)⁹ Conigrave A.D....Brown E.M. (2000)
125. Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness. (PubMed id 10993889)⁹ Paquet Y....Anderson A. (2000)
126. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. (PubMed id 10748001)⁹ Moore L.B....Kliewer S.A. (2000)
127. A carboxyl-terminal domain controls the cooperativity for extracellular Ca2+ activation of the human calcium sensing receptor. A study with receptor-green fluorescent protein fusions. (PubMed id 9792684)⁹ Gama L. and Breitwieser G.E. (1998)
128. Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat consti tutive androstane receptor. (PubMed id 19920082)⁹ Kanno Y....Inouye Y. (2010)
129. Constitutive androstane/active receptor is a target o f retinoic acid receptor in humans. (PubMed id 20211151)⁹ Saito K....Chiba K. (2010)
130. The unique complexity of the CYP3A4 upstream region s uggests a nongenetic explanation of its expression variability. (PubMed id 20147837)⁹ Qiu H....Wojnowski L. (2010)
131. Genetic polymorphisms in the TATA box and upstream ph enobarbital-responsive enhancer module of the UGT1A1 promoter have combined eff ects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human l iver. (PubMed id 19541828)⁹ Li Y....Zhong X.B. (2009)
132. Activation of pregnane X receptor (PXR) and constitut ive androstane receptor (CAR) by herbal medicines. (PubMed id 19688601)⁹ Chang T.K. (2009)
133. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. (PubMed id 19211671)⁹ DeKeyser J.G....Omiecinski C.J. (2009)
134. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. (PubMed id 18474683)⁹ Merrell M.D....Cherrington N.J. (2008)
135. The peripheral benzodiazepine receptor ligand 1-(2-ch lorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of hu man constitutive androstane receptor. (PubMed id 18492798)⁹ Li L....Wang H. (2008)
136. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. (PubMed id 17392393)⁹ Cerveny L....Pavek P. (2007)
137. [Effect of constitutive androstane receptor on the cy totoxicity of mitomycin C and 5-(aziridin-1-yl)-3-hydroxymethyl-1-methylindole- 4,7-dione] (PubMed id 17633202)⁹ Zhang J.H....Jin Y.Z. (2007)
138. The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. (PubMed id 17595319)⁹ Echchgadda I....Chatterjee B. (2007)
139. Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. (PubMed id 17353348)⁹ Fisher C.D....Cherrington N.J. (2007)
140. [Role of PXR and CAR in cholestasis] (PubMed id 16565602)⁹ Suh J.I. (2006)
141. Different modulation of ER-mediated transactivation by xenobiotic nuclear receptors depending on the estrogen response elements and estrogen target cell types. (PubMed id 17341619)⁹ Min G. (2006)
142. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). (PubMed id 16684648)⁹ Chang T.K. and Waxman D.J. (2006)
143. The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. (PubMed id 15833898)⁹ Ding X. and Staudinger J.L. (2005)
144. Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. (PubMed id 15572354)⁹ Sakwe A.M....Gylfe E. (2005)
145. Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). (PubMed id 16197547)⁹ Krasowski M.D....Schuetz E.G. (2005)
146. Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression. (PubMed id 15882563)⁹ Burton D.W....Terkeltaub R. (2005)
147. Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity. (PubMed id 15616833)⁹ Windshugel B....Sippl W. (2005)
148. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). (PubMed id 16099843)⁹ Auerbach S.S....Omiecinski C.J. (2005)
149. Identification of HMG-CoA reductase inhibitors as act ivators for human, mouse and rat constitutive androstane receptor. (PubMed id 15802384)⁹ Kobayashi K....Chiba K. (2005)
150. Animal models of xenobiotic receptors. (PubMed id 16101573)⁹ Dai G. and Wan Y.J. (2005)
151. Modulation of interprotomer relationships is important for activation of dimeric calcium-sensing receptor. (PubMed id 14729680)⁹ Jiang Y....Bai M. (2004)
152. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. (PubMed id 12571232)⁹ Wang H....LeCluyse E.L. (2003)
153. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors. (PubMed id 11981033)⁹ Moore L.B....Moore J.T. (2002)
154. Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. (PubMed id 11518807)⁹ Handschin C....Meyer U.A. (2001)
155. Extracellular calcium sensing and extracellular calcium signaling. (PubMed id 11152759)⁹ Brown E.M. and MacLeod R.J. (2001)
156. The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation. (PubMed id 10660604)⁹ Kassam A....Rachubinski R.A. (2000)
157. Calcium-sensing receptor and calcimimetic agents. (PubMed id 10633465)⁹ Coburn J.W....Frazao J.M. (1999)
158. Random mutagenesis of the cAMP chemoattractant recept or, cAR1, of Dictyostelium. Evidence for multiple states of activation. (PubMed id 8999904)⁹ Milne J.L....Devreotes P.N. (1997)
159. Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. (PubMed id 7876207)⁹ Caterina M.J....Devreotes P.N. (1995)
160. Overexpression of the cAMP receptor 1 in growing Dictyostelium cells. (PubMed id 1648967)⁹ Johnson R.L....Devreotes P.N. (1991)
161. Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates. (PubMed id 19428328)⁹ Eveillard A....Pineau T. (2009)
162. Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes. (PubMed id 18334917)⁹ Roth A....Meyer U.A. (2008)
163. Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies. (PubMed id 16918499)⁹ Poso A. and Honkakoski P. (2006)
164. Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. (PubMed id 15761118)⁹ Burk O....Eichelbaum M. (2005)
165. The calcium-sensing receptor as a nutrient sensor. (PubMed id 15667336)⁹ Riccardi D. and Maldonado-Perez D. (2005)
166. Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. (PubMed id 15591315)⁹ Xia J. and Kemper B. (2005)
167. The calcium-sensing receptor (CaR) and its disorders. (PubMed id 17018434)⁹ Brown E.M. (2002)
168. Wellcome Prize Lecture. Cell surface, ion-sensing receptors. (PubMed id 12392104)⁹ Riccardi D. (2002)
169. Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1. (PubMed id 11256950)⁹ Muangmoonchai R....Shephard E.A. (2001)
170. Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotid e polymorphisms. (PubMed id 19558188)⁹ Meyer zu Schwabedissen H.E. and Kim R.B. (2009)
171. Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. (PubMed id 18786598)⁹ Nannelli A....Gervasi P.G. (2008)
172. Calcium sensing receptor activators: calcimimetics. (PubMed id 18220738)⁹ Harrington P.E. and Fotsch C. (2007)
173. Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. (PubMed id 16749864)⁹ Al-Dosari M.S....Liu D. (2006)
174. Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. (PubMed id 16635107)⁹ Gillberg M....Friis C. (2006)
175. Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. (PubMed id 16243958)⁹ Vyhlidal C.A....Leeder J.S. (2006)
176. Beyond CAR and PXR. (PubMed id 16101576)⁹ Dixit S.G....Kim R.B. (2005)
177. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells. (PubMed id 14696958)⁹ Shalhoub V....Martin D. (2003)
178. Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. (PubMed id 14683479)⁹ Wang H. and Negishi M. (2003)
179. Functional and structural comparison of PXR and CAR. (PubMed id 12573482)⁹ Moore J.T....Kliewer S.A. (2003)
180. Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. (PubMed id 11891851)⁹ Toell A....Carlberg C. (2002)
181. A randomized, cross-over trial of once-daily versus twice-daily parathyroid hormone 1-34 in treatment of hypoparathyroidism. (PubMed id 9768650)⁹ Winer K.K....Cutler G.B. (1998)
182. Roles of calcium-sensing receptor and vitamin d recep tor in the pathophysiology of secondary hyperparathyroidism. (PubMed id 20303786)⁹ McCann L.M. and Beto J. (2010)
183. A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive spl icing variant CAR3. (PubMed id 19820207)⁹ Chen T....Wang H. (2010)
184. CYP2C9*1B promoter polymorphisms, in linkage with CYP 2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. (PubMed id 19855097)⁹ Chaudhry A.S....Schuetz E.G. (2010)
185. Bile acid-activated receptors in the treatment of dys lipidemia and related disorders. (PubMed id 19932133)⁹ Fiorucci S....Mencarelli A. (2010)
186. The effects of cytochrome P450 induction by xenobioti cs on endobiotic metabolism in pre-clinical safety studies. (PubMed id 20218941)⁹ Amacher D.E. (2010)
187. Coordinate regulation of metabolic enzymes and transp orters by nuclear transcription factors in human liver disease. (PubMed id 19638083)⁹ Congiu M....Desmond P.V. (2009)
188. Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. (PubMed id 18981260)⁹ Konno Y....Negishi M. (2009)
189. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA. (PubMed id 18805405)⁹ Yu C....Zeng S. (2009)
190. Xenobiotic-Sensing Nuclear Receptors CAR and PXR as D rug Targets in Cholestatic Liver Disease. (PubMed id 19925451)⁹ Kakizaki S....Mori M. (2009)
191. [The role of calcium, calcitriol and their receptors in parathyroid regulation] (PubMed id 19396314)⁹ Carrillo-LA^pez N....Cannata-AndA-a J.B. (2009)
192. Farnesoid X receptor agonists in biliary tract disease. (PubMed id 19300246)⁹ Fiorucci S. and Baldelli F. (2009)
193. Integrated comparison of drug-related and drug-induce d ultra performance liquid chromatography/mass spectrometry metabonomic profile s using human hepatocyte cultures. (PubMed id 19588937)⁹ Croixmarie V....Walther B. (2009)
194. [Polymorphism and the level of P450 gene expression i n xenobiotic metabolism] (PubMed id 19928584)⁹ Niemira M....Mazerska Z. (2009)
195. A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures. (PubMed id 18832183)⁹ Baldwin W.S. and Roling J.A. (2009)
196. Octachlorostyrene induces cytochrome P450, UDP-glucur onosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and c onstitutive androstane receptor. (PubMed id 19525444)⁹ Yanagiba Y....Nakajima T. (2009)
197. Molecular characterization of SMILE as a novel corepressor of nuclear receptors. (PubMed id 19429690)⁹ Xie Y.B....Choi H.S. (2009)
198. Involvement of Vitamin D receptor in the intestinal i nduction of human ABCB1. (PubMed id 19460946)⁹ Tachibana S....Yamazoe Y. (2009)
199. Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism. (PubMed id 18781912)⁹ Gollamudi R....Mani S. (2008)
200. [Molecular mechanisms linking xenobiotic metabolism and inflammation] (PubMed id 18334180)⁹ Pascussi J.M. and Vilarem M.J. (2008)
201. Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. (PubMed id 18159929)⁹ Moreau A....Pascussi J.M. (2008)
202. ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. (PubMed id 19094056)⁹ Dauchy S....DeclA"ves X. (2008)
203. Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents. (PubMed id 19084913)⁹ Mottino A.D. and Catania V.A. (2008)
204. Inflammatory cytokine signaling in insulin producing beta-cells enhances the colocalization correlation coefficient between L-type voltage-dependent calcium channel and calcium-sensing receptor. (PubMed id 18636168)⁹ Parkash J. (2008)
205. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. (PubMed id 18332086)⁹ Gupta A....Unadkat J.D. (2008)
206. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. (PubMed id 18327154)⁹ Chen H.L....Chang M.H. (2008)
207. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. (PubMed id 17041008)⁹ Faucette S.R....Wang H. (2007)
208. Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. (PubMed id 17139321)⁹ Au T....Reid T.R. (2007)
209. Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. (PubMed id 17827783)⁹ Kamiyama Y....Yamazoe Y. (2007)
210. Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. (PubMed id 17344806)⁹ Saussele T....Zanger U.M. (2007)
211. Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. (PubMed id 17217392)⁹ Greger D.L. and Blum J.W. (2007)
212. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. (PubMed id 16513849)⁹ Faucette S.R....Wang H. (2006)
213. Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. (PubMed id 16936065)⁹ Jackson J.P....Goldstein J.A. (2006)
214. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. (PubMed id 16606610)⁹ Yamamoto Y....Negishi M. (2006)
215. Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. (PubMed id 16988011)⁹ Rencurel F....Meyer U.A. (2006)
216. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. (PubMed id 17132852)⁹ Moore D.D....Kliewer S.A. (2006)
217. DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue. (PubMed id 16962182)⁹ Hu R....LoVerde P.T. (2006)
218. AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. (PubMed id 15572372)⁹ Rencurel F....Wolf C.R. (2005)
219. Coordinate transcriptional regulation of transport and metabolism. (PubMed id 16399367)⁹ Eloranta J.J....Kullak-Ublick G.A. (2005)
220. A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo. (PubMed id 15637285)⁹ Arey B.J....Feyen J.H. (2005)
221. Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response. (PubMed id 15198932)⁹ Kim M.S....Feingold K.R. (2004)
222. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. (PubMed id 15123723)⁹ Wang H....LeCluyse E. (2004)
223. Extracellular calcium downregulates estrogen receptor alpha and increases its transcriptional activity through calcium-sensing receptor in breast cancer cells. (PubMed id 15268900)⁹ JournAc F....Body J.J. (2004)
224. Extracellular calcium sensing receptor: an overview of physiology, pathophysiology and clinical perspectives. (PubMed id 15646815)⁹ Msaouel P....Kentarchos N.E. (2004)
225. The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. (PubMed id 15155833)⁹ Jackson J.P....Goldstein J.A. (2004)
226. Effects of triaryl phosphates on mouse and human nuclear receptors. (PubMed id 14667932)⁹ Honkakoski P....Auriola S. (2004)
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228. Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teeth. (PubMed id 12746335)⁹ Whitfield G.K....Marchalonis J.J. (2003)
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230. Calcimimetic agents: review and perspectives. (PubMed id 12753275)⁹ Urena P. and Frazao J.M. (2003)
231. Use of calcimimetics in uremic patients with secondary hyperparathyroidism: review. (PubMed id 12940896)⁹ Urena P. (2003)
232. The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. (PubMed id 12853622)⁹ Maglich J.M....Ramamurthy L. (2003)
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237. Amino acids and Ca2+ stimulate different patterns of Ca2+ oscillations through the Ca2+-sensing receptor. (PubMed id 11997256)⁹ Young S.H. and Rozengurt E. (2002)
238. Calcium sensing receptor activation by a calcimimetic suggests a link between cooperativity and intracellular calcium oscillations. (PubMed id 12399473)⁹ Miedlich S....Breitwieser G.E. (2002)
239. Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. (PubMed id 12181440)⁹ Maglich J.M....Kliewer S.A. (2002)
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241. A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. (PubMed id 12523656)⁹ Ekins S....Schuetz E.G. (2002)
242. Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. (PubMed id 12045201)⁹ Handschin C....Meyer U.A. (2002)
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245. The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. (PubMed id 11319871)⁹ Briscoe C....Firtel R.A. (2001)
246. Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU. (PubMed id 11113125)⁹ Kim J....Kemper B. (2001)
247. A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR). (PubMed id 11405283)⁹ Honkakoski P....Urtti A. (2001)
248. Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7. (PubMed id 11162490)⁹ Bertilsson G....Blomquist P. (2001)
249. CaR-mediated COX-2 expression in primary cultured mTAL cells. (PubMed id 11553512)⁹ Wang D....Ferreri N.R. (2001)
250. Human gastrinoma cells express calcium-sensing receptor. (PubMed id 11787938)⁹ Itami A....Imamura M. (2001)
251. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. (PubMed id 11093784)⁹ Pascussi J.M....Vilarem M.J. (2000)
252. Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. (PubMed id 10886547)⁹ Petrucci M....Bonnardeaux A. (2000)
253. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. (PubMed id 10924340)⁹ Pascussi J.M....Vilarem M.J. (2000)
254. Defective extracellular calcium (Ca(o))-sensing receptor (CaR)-mediated stimulation of a Ca(2+)-activated potassium channel in glioblastoma cells transfected with a dominant negative CaR. (PubMed id 11038250)⁹ Ye C....Vassilev P.M. (2000)
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257. 1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes. (PubMed id 10048583)⁹ Ratnam A.V....Cho J.K. (1999)
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262. Xenobiotic-metabolizing cytochromes p450 in human whi te adipose tissue: expression and induction. (PubMed id 20035023)⁹ Ellero S....de Waziers I. (2010)
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264. Up-regulation of CYP expression in hepatoma cells sta bly transfected by chimeric nuclear receptors. (PubMed id 20381613)⁹ KA1blbeck J....Honkakoski P. (2010)
265. Retinoids activate RXR/CAR-mediated pathway and induc e CYP3A. (PubMed id 19686701)⁹ Chen S....Wan Y.J. (2010)
266. Enhanced steatosis by nuclear receptor ligands: a stu dy in cultured human hepatocytes and hepatoma cells with a characterized nuclea r receptor expression profile. (PubMed id 20079722)⁹ Moya M....Jover R. (2010)
267. The regulation of UDP-glucuronosyltransferase genes b y tissue-specific and ligand-activated transcription factors. (PubMed id 20070244)⁹ Mackenzie P.I....Gardner-Stephen D.A. (2010)
268. Constitutive androstane receptor mediates the inducti on of drug metabolism in mouse models of type 1 diabetes. (PubMed id 19489075)⁹ Dong B....Moore D.D. (2009)
269. Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adul t human livers. (PubMed id 19480556)⁹ Aleksunes L.M....Klaassen C.D. (2009)
270. Transcriptional regulation of cytochrome p450 genes b y the nuclear receptor hepatocyte nuclear factor 4-alpha. (PubMed id 19689247)⁹ Jover R....GA^mez-LechA^n M.J. (2009)
271. Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HN F4alpha. (PubMed id 19467232)⁹ Inoue K. and Negishi M. (2009)
272. Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells. (PubMed id 19286836)⁹ Ellfolk M....Wikvall K. (2009)
273. Antagonists of the calcium receptor I. Amino alcohol- based parathyroid hormone secretagogues. (PubMed id 19492813)⁹ Marquis R.W....Bhatnagar P. (2009)
274. Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. (PubMed id 19427329)⁹ di Masi A....Marino M. (2009)
275. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. (PubMed id 19202563)⁹ Sahi J....LeCluyse E.L. (2009)
276. Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action. (PubMed id 19176367)⁹ Yamada T....Kaneko H. (2009)
277. Dexamethasone induction of murine CYP2B genes requires the glucocorticoid receptor. (PubMed id 19047470)⁹ Audet-Walsh E. and Anderson A. (2009)
278. Studies on induction of lamotrigine metabolism in tra nsgenic UGT1 mice. (PubMed id 19845433)⁹ Argikar U.A....Remmel R.P. (2009)
279. Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. (PubMed id 19162173)⁹ Ren H....Corton J.C. (2009)
280. Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. (PubMed id 19041851)⁹ Dauchy S....DeclA"ves X. (2009)
281. Nuclear receptors as therapeutic targets in cholestatic liver diseases. (PubMed id 19133988)⁹ Zollner G. and Trauner M. (2009)
282. High-throughput screening for analysis of in vitro toxicity. (PubMed id 19157069)⁹ Schoonen W.G....Horbach G.J. (2009)
283. Farnesoid X receptor critically determines the fibrot ic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. (PubMed id 19910507)⁹ Fickert P....Trauner M. (2009)
284. Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio. (PubMed id 19273385)⁹ Modica S....Moschetta A. (2009)
285. Transcriptional corepressor SMILE recruits SIRT1 to i nhibit nuclear receptor estrogen receptor-related receptor gamma transactivatio n. (PubMed id 19690166)⁹ Xie Y.B....Choi H.S. (2009)
286. Treatment of secondary hyperparathyroidism in CKD patients with cinacalcet and/or vitamin D derivatives. (PubMed id 19056615)⁹ DrA1eke T.B. and Ritz E. (2009)
287. Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. (PubMed id 18606396)⁹ KAPhle C. and Bock K.W. (2009)
288. Drug-metabolising enzymes are down-regulated by hypox ia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP 3A4 repression. (PubMed id 19695866)⁹ Legendre C....Morel F. (2009)
289. 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway. (PubMed id 19961161)⁹ Chu W.C....Su J.G. (2009)
290. Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. (PubMed id 19363144)⁹ Nesnow S....Hester S.D. (2009)
291. Methadone induces the expression of hepatic drug-meta bolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor. (PubMed id 19520773)⁹ Tolson A.H....Wang H. (2009)
292. Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent. (PubMed id 18971317)⁹ Monostory K....Rozman D. (2009)
293. Bile Acid sulfation: a pathway of bile acid elimination and detoxification. (PubMed id 19131563)⁹ Alnouti Y. (2009)
294. Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. (PubMed id 19409404)⁹ Goetz A.K. and Dix D.J. (2009)
295. Mode-of-action analysis for induction of rat liver tu mors by pyrethrins: relevance to human cancer risk. (PubMed id 19463055)⁹ Osimitz T.G. and Lake B.G. (2009)
296. Investigation of the CYP2C9 induction profile in huma n hepatocytes by combining experimental and modelling approaches. (PubMed id 20167002)⁹ Belic A....Monostory K. (2009)
297. Expression, function and regulation of mouse cytochro me P450 enzymes: comparison with human P450 enzymes. (PubMed id 20166999)⁹ Hrycay E.G. and Bandiera S.M. (2009)
298. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. (PubMed id 19275551)⁹ Zordoky B.N. and El-Kadi A.O. (2009)
299. Antiepileptic drugs reduce efficacy of methotrexate c hemotherapy by downregulation of Reduced folate carrier transport activity. (PubMed id 19212336)⁹ Halwachs S....Honscha W. (2009)
300. Species differences in the hepatic effects of inducer s of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour forma tion. (PubMed id 19622001)⁹ Lake B.G. (2009)
301. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. (PubMed id 18778245)⁹ Finn R.D....Wolf C.R. (2009)
302. Human CYP2C8: structure, substrate specificity, inhib itor selectivity, inducers and polymorphisms. (PubMed id 20214592)⁹ Lai X.S....Zhou S.F. (2009)
303. Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064. (PubMed id 19228886)⁹ MartA-nez-FernA!ndez P....Alvarez L. (2009)
304. Impact of cholesterol on ABC and SLC transporters exp ression and function and its role in disposition variability to lipid-lowering drugs. (PubMed id 19530968)⁹ Rodrigues A.C....Hirata R.D. (2009)
305. The transcriptional regulation of the human CYP2C gen es. (PubMed id 19702536)⁹ Chen Y. and Goldstein J.A. (2009)
306. Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants. (PubMed id 18536954)⁹ Ceglia L....Dawson-Hughes B. (2009)
307. Substrates, inducers, inhibitors and structure-activi ty relationships of human Cytochrome P450 2C9 and implications in drug developm ent. (PubMed id 19515014)⁹ Zhou S.F....Cai J.P. (2009)
308. Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. (PubMed id 19378387)⁹ Hirose Y....Okuno Y. (2009)
309. Interplay of pregnane X receptor with other nuclear receptors on gene regulation. (PubMed id 18305371)⁹ Lim Y.P. and Huang J.D. (2008)
310. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor. (PubMed id 18096673)⁹ Healan-Greenberg C....Kim R.B. (2008)
311. Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. (PubMed id 18457366)⁹ Ku K.L....Liao H.F. (2008)
312. The nuclear hormone receptor family round the clock. (PubMed id 18653780)⁹ Teboul M....Delaunay F. (2008)
313. Induction of drug metabolism: Species differences and toxicological relevance. (PubMed id 18824059)⁹ Graham M.J. and Lake B.G. (2008)
314. Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. (PubMed id 18989830)⁹ Kenny J.R....Riley R. (2008)
315. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. (PubMed id 18342837)⁹ Dickmann L.J....Isoherranen N. (2008)
316. The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. (PubMed id 18537574)⁹ Ma Q. and Lu A.Y. (2008)
317. New insights on the xenobiotic-sensing nuclear recept ors in liver diseases--CAR and PXR--. (PubMed id 18781913)⁹ Kakizaki S....Negishi M. (2008)
318. Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. (PubMed id 18408076)⁹ Nakagawa K....Schmitt C.P. (2008)
319. Regulation of transporters by nuclear hormone receptors: implications during inflammation. (PubMed id 18072749)⁹ Teng S. and Piquette-Miller M. (2008)
320. Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. (PubMed id 18172616)⁹ Sugatani J....Miwa M. (2008)
321. Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. (PubMed id 17940135)⁹ Siest G....Visvikis-Siest S. (2008)
322. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. (PubMed id 18692084)⁹ Kleiner H.E....DiGiovanni J. (2008)
323. Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. (PubMed id 18706437)⁹ Perez M.J....Marin J.J. (2008)
324. Catecholamines induce an inflammatory response in human hepatocytes. (PubMed id 18431272)⁹ Aninat C....Guillouzo A. (2008)
325. Calcimimetics in CKD-results from recent clinical studies. (PubMed id 18594867)⁹ Schlieper G. and Floege J. (2008)
326. Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. (PubMed id 18037906)⁹ Martin P....Owen A. (2008)
327. CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. (PubMed id 18781911)⁹ Wang H. and Tompkins L.M. (2008)
328. Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. (PubMed id 18686044)⁹ Sinz M....Sahi J. (2008)
329. [New perspectives in the use of human hepatocytes in the preclinical drug development process] (PubMed id 19061728)⁹ Guillouzo A. (2008)
330. The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription. (PubMed id 18362160)⁹ Yamamoto Y. and Negishi M. (2008)
331. Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). (PubMed id 18703021)⁹ Haslam I.S....Simmons N.L. (2008)
332. Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. (PubMed id 18332078)⁹ Hariparsad N....Chu X. (2008)
333. Extracellular calcium as an integrator of tissue function. (PubMed id 18328773)⁹ Breitwieser G.E. (2008)
334. Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. (PubMed id 18328680)⁹ Olinga P....Groothuis G.M. (2008)
335. Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. (PubMed id 18347084)⁹ Harmsen S....Meijerman I. (2008)
336. The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. (PubMed id 17608617)⁹ Pascussi J.M....Maurel P. (2008)
337. Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. (PubMed id 17223708)⁹ Wright E....Fernandez E.J. (2007)
338. Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor. (PubMed id 17241389)⁹ Kakizaki S....Mori M. (2007)
339. Selected technologies to control genes and their prod ucts for experimental and clinical purposes. (PubMed id 17557142)⁹ Alexander H.K....Los M. (2007)
340. The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. (PubMed id 17451886)⁹ Harmsen S....Schellens J.H. (2007)
341. Mechanisms of cytochrome P450 induction. (PubMed id 17936931)⁹ Tompkins L.M. and Wallace A.D. (2007)
342. Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. (PubMed id 16831563)⁹ Windshugel B....Sippl W. (2007)
343. Transcriptional regulation and expression of CYP3A4 in hepatocytes. (PubMed id 17305497)⁹ Martinez-Jimenez C.P....Gomez-Lechon M.J. (2007)
344. Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs. (PubMed id 16919959)⁹ Vaccarino A.L....Bazan N.G. (2007)
345. Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. (PubMed id 17979873)⁹ Hu J. and Spiegel A.M. (2007)
346. Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). (PubMed id 17526421)⁹ Niimi S....Tanabe S. (2007)
347. Clinical lessons from the calcium-sensing receptor. (PubMed id 17237839)⁹ Brown E.M. (2007)
348. Aromatic L-amino acids activate the calcium-sensing receptor. (PubMed id 17513419)⁹ Conigrave A.D....Lok H.C. (2007)
349. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. (PubMed id 17442683)⁹ Urquhart B.L....Kim R.B. (2007)
350. Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes. (PubMed id 16964586)⁹ Dvorak Z....Modriansky M. (2007)
351. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. (PubMed id 17637504)⁹ Westerink W.M. and Schoonen W.G. (2007)
352. Nuclear receptors in human immune cells: expression and correlations. (PubMed id 16837048)⁹ Schote A.B....Muller C.P. (2007)
353. Pancreatitis in primary hyperparathyroidism-related hypercalcaemia is not associated with mutations in the CASR gene. (PubMed id 17853337)⁹ Felderbauer P....Schmidt W.E. (2007)
354. Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. (PubMed id 17696930)⁹ Zollner G....Trauner M. (2007)
355. Targeting farnesoid X receptor for liver and metabolic disorders. (PubMed id 17588816)⁹ Fiorucci S....Santucci L. (2007)
356. CAR and PXR: the xenobiotic-sensing receptors. (PubMed id 17284330)⁹ Timsit Y.E. and Negishi M. (2007)
357. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. (PubMed id 17291602)⁹ Geier A....Trauner M. (2007)
358. Genomic profiling in nuclear receptor-mediated toxicity. (PubMed id 17562482)⁹ Woods C.G....Rusyn I. (2007)
359. Targeting carcinogen metabolism by dietary cancer preventive compounds. (PubMed id 17691900)⁹ Yu S. and Kong A.N. (2007)
360. (Far) Outside the box: genomic approach to acute porphyria. (PubMed id 17298222)⁹ Thunell S. (2006)
361. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. (PubMed id 16837569)⁹ Jigorel E....Fardel O. (2006)
362. Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. (PubMed id 16623664)⁹ Inoue K....Negishi M. (2006)
363. Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome. (PubMed id 17118915)⁹ Slatter J.G....Ulrich R.G. (2006)
364. AMSH regulates calcium-sensing receptor signaling through direct interactions. (PubMed id 16854379)⁹ Herrera-Vigenor F....Reyes-Cruz G. (2006)
365. Herb-drug interactions in oncology: focus on mechanisms of induction. (PubMed id 16880233)⁹ Meijerman I....Schellens J.H. (2006)
366. Cholestasis and cholestatic syndromes. (PubMed id 16550034)⁹ Rutherford A.E. and Pratt D.S. (2006)
367. Metabolic learning in the intestine: adaptation to nutrition and luminal factors. (PubMed id 16933181)⁹ Schmitz G. and Langmann T. (2006)
368. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. (PubMed id 16557225)⁹ Bushinsky D.A....Asplin J.R. (2006)
369. Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenes is, and mechanism. (PubMed id 16724929)⁹ Yamada H....Oguri K. (2006)
370. Significance of the minor cytochrome P450 3A isoforms. (PubMed id 16430309)⁹ Daly A.K. (2006)
371. Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7. (PubMed id 17341620)⁹ Min G. (2006)
372. Parathyroid growth and suppression in renal failure. (PubMed id 16689976)⁹ Lewin E....Olgaard K. (2006)
373. Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. (PubMed id 16918318)⁹ Mandlekar S....Kong A.N. (2006)
374. Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). (PubMed id 16288980)⁹ Macchiarulo A....Pellicciari R. (2006)
375. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. (PubMed id 16608920)⁹ Duret C....Gerbal-Chaloin S. (2006)
376. Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. (PubMed id 17112801)⁹ Oscarson M....Meyer U.A. (2006)
377. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. (PubMed id 16857725)⁹ Itoh M....Yokoi T. (2006)
378. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. (PubMed id 16291838)⁹ Levi R....Silver J. (2006)
379. Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors. (PubMed id 16749854)⁹ Trottier J....Barbier O. (2006)
380. NFAT regulates calcium-sensing receptor-mediated TNF production. (PubMed id 16380462)⁹ Abdullah H.I....Ferreri N.R. (2006)
381. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. (PubMed id 16204462)⁹ Aninat C....Guillouzo A. (2006)
382. Influence of parathyroid mass on the regulation of PTH secretion. (PubMed id 16810305)⁹ Lewin E. and Olgaard K. (2006)
383. Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. (PubMed id 16603723)⁹ Chattopadhyay N. (2006)
384. Regulation of CYP3A genes in the human respiratory tract. (PubMed id 15698577)⁹ Raunio H....Pelkonen O. (2005)
385. Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases. (PubMed id 16101569)⁹ Zhou J....Xie W. (2005)
386. Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans. (PubMed id 15888568)⁹ CaA+adillas S....AlmadAcn Y. (2005)
387. [How to slow down parathyroid hormone (PTH) secretion without the risk of inducing an adynamic bone disease] (PubMed id 17373205)⁹ Torres P.U. and Canaud B. (2005)
388. [The role of calcium ions in the pathomechanism of the artery calcification accompanying atherosclerosis] (PubMed id 15761385)⁹ MaA8ecki R. and Adamiec R. (2005)
389. Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. (PubMed id 15837785)⁹ Rey O....Rozengurt E. (2005)
390. Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism. (PubMed id 16189180)⁹ Kawata T....Nishizawa Y. (2005)
391. Regulation of sulfotransferases by xenobiotic receptors. (PubMed id 16101570)⁹ Runge-Morris M. and Kocarek T.A. (2005)
392. Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. (PubMed id 15686947)⁹ Yang W....Dickson J.K. (2005)
393. Animal models of xenobiotic receptors in drug metabolism and diseases. (PubMed id 16399373)⁹ Gong H....Xie W. (2005)
394. Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor. (PubMed id 16399345)⁹ Sugatani J....Miwa M. (2005)
395. [The calcium receptor and magnesium metabolism] (PubMed id 16272613)⁹ Kawata T. and Nagano N. (2005)
396. Regulation of hepatic transporters by xenobiotic receptors. (PubMed id 16101571)⁹ Klaassen C.D. and Slitt A.L. (2005)
397. [Drugs inhibiting parathyroid hormone (PTH) secretion by control of the calcium receptor (calcimimetics)--effect on the set point of calcium-regulated PTH secretion.] (PubMed id 15632475)⁹ Nagano N. (2005)
398. Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. (PubMed id 16399349)⁹ Chatterjee B....Song C.S. (2005)
399. Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases. (PubMed id 16259220)⁹ Chiang J.Y. (2005)
400. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. (PubMed id 15581595)⁹ Handschin C. and Meyer U.A. (2005)
401. Genetic variations and haplotypes of CYP2C19 in a Japanese population. (PubMed id 16141610)⁹ Fukushima-Uesaka H.... Sawada J. (2005)
402. Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. (PubMed id 16230703)⁹ Kruger K.A....Greger D.L. (2005)
403. Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. (PubMed id 16025508)⁹ Karpen S.J. (2005)
404. Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells. (PubMed id 16188404)⁹ Malaplate-Armand C....Batt A.M. (2005)
405. Cinacalcet HCl: a novel therapeutic for hyperparathyroidism. (PubMed id 15794735)⁹ de Francisco A.L. (2005)
406. A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism. (PubMed id 15608136)⁹ Ekins S....Nikolskaya T. (2005)
407. Nuclear receptors and drug disposition gene regulation. (PubMed id 15858847)⁹ Tirona R.G. and Kim R.B. (2005)
408. [Calcium sensing receptor (CaR) agonist] (PubMed id 15926471)⁹ Mizobuchi M. and Akizawa T. (2005)
409. [Calcimimetics--a new treatment for hyperparathyroidism?] (PubMed id 16161961)⁹ Piecha G....Wiecek A. (2005)
410. Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. (PubMed id 15557560)⁹ Sugatani J....Miwa M. (2005)
411. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. (PubMed id 15905360)⁹ LempiAoinen H....Carlberg C. (2005)
412. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. (PubMed id 15507543)⁹ Rodriguez M....Martin D. (2005)
413. Induction of phase I, II and III drug metabolism/transport by xenobiotics. (PubMed id 15832810)⁹ Xu C....Kong A.N. (2005)
414. Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. (PubMed id 15888456)⁹ Molnar F....Carlberg C. (2005)
415. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. (PubMed id 16039771)⁹ Souidi M....Dublineau I. (2005)
416. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. (PubMed id 16399343)⁹ Bock K.W. and Kohle C. (2005)
417. Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers. (PubMed id 15849716)⁹ Smith C.M....LeCluyse E.L. (2005)
418. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. (PubMed id 16166224)⁹ Rodriguez L....Chang W. (2005)
419. Induction of cytochromes P450. (PubMed id 15579106)⁹ Dickins M. (2004)
420. Coordinate regulation of drug metabolism by xenobioti c nuclear receptors: UGTs acting together with CYPs and glucuronide transporter s. (PubMed id 15554238)⁹ Bock K.W. and KAPhle C. (2004)
421. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (PubMed id 15004017)⁹ Assem M....Schuetz J.D. (2004)
422. Primary hyperparathyroidism. Update on pathophysiology, clinical presentation and surgical treatment. (PubMed id 15658669)⁹ Farnebo L.O. (2004)
423. CAR: detailing new models. (PubMed id 15276713)⁹ Goodwin B. and Moore J.T. (2004)
424. Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. (PubMed id 15135080)⁹ You L. (2004)
425. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? (PubMed id 15459087)⁹ Ory D.S. (2004)
426. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. (PubMed id 15104253)⁹ Sugatani J....Miwa M. (2004)
427. CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. (PubMed id 15578943)⁹ Luo G....Humphreys W.G. (2004)
428. [Patomechanism of diabetic macroangiopathy. The role of calcium-sensing receptor (CaR)] (PubMed id 15526852)⁹ MaA8ecki R. and Adamiec R. (2004)
429. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. (PubMed id 15051872)⁹ Dvorak M.M....Riccardi D. (2004)
430. L-amino acids regulate parathyroid hormone secretion. (PubMed id 15234970)⁹ Conigrave A.D....Brown E.M. (2004)
431. Clinical experience with cinacalcet HCl. (PubMed id 15284357)⁹ UreA+a Torres P. (2004)
432. Renal COX-2, cytokines and 20-HETE: tubular and vascular mechanisms. (PubMed id 14965324)⁹ Ferreri N.R....Quilley J. (2004)
433. Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization. (PubMed id 14701866)⁹ Holstein D.M....Saunders C. (2004)
434. Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). (PubMed id 15000748)⁹ Bae Y....Kemper B. (2004)
435. Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia. (PubMed id 14625199)⁹ Wang W....Nielsen S. (2004)
436. Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential. (PubMed id 14996618)⁹ Gong H. and Xie W. (2004)
437. Evaluation of the toxicological relevance of CYP3A4 induction. (PubMed id 12613276)⁹ Plant N.J. and Gibson G.G. (2003)
438. Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells. (PubMed id 12893520)⁹ Swales K....Gibson G. (2003)
439. Orphan nuclear receptor modulators. (PubMed id 14683519)⁹ Mohan R. and Heyman R.A. (2003)
440. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. (PubMed id 14671147)⁹ Shoback D.M....Peacock M. (2003)
441. Repression of farnesoid X receptor during the acute phase response. (PubMed id 12519762)⁹ Kim M.S....Grunfeld C. (2003)
442. Vitamin D regulated keratinocyte differentiation: role of coactivators. (PubMed id 12520529)⁹ Bikle D.D....Oda Y. (2003)
443. Transgenic mouse models of human CYP3A4 gene regulation. (PubMed id 12815159)⁹ Robertson G.R....Liddle C. (2003)
444. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. (PubMed id 14551287)⁹ Lamba V.... Schuetz E.G. (2003)
445. Regulation of drug and bile salt transporters in liver and intestine. (PubMed id 14705863)⁹ Kullak-Ublick G.A. and Becker M.B. (2003)
446. Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery. (PubMed id 14575522)⁹ Maglich J.M....Moore J.T. (2003)
447. Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure. (PubMed id 12710995)⁹ Jacobs M.N....Lewis D.F. (2003)
448. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. (PubMed id 12566446)⁹ Yueh M.F....Tukey R.H. (2003)
449. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. (PubMed id 12815172)⁹ Dvorak Z....Pascussi J.M. (2003)
450. Regulation of UDP glucuronosyltransferase genes. (PubMed id 12769669)⁹ Mackenzie P.I....Radominska-Pandya A. (2003)
451. Drug-activated nuclear receptors CAR and PXR. (PubMed id 12822739)⁹ Honkakoski P....Negishi M. (2003)
452. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. (PubMed id 12695351)⁹ Wang H....LeCluyse E.L. (2003)
453. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. (PubMed id 12573484)⁹ Pascussi J.M....Vilarem M.J. (2003)
454. Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19. (PubMed id 12668916)⁹ Arefayene M....Flockhart D.A. (2003)
455. Quantitation of CYP2B6, constitutive androstane receptor, and pregnane X receptor mRNA levels. (PubMed id 12718301)⁹ Hesse L.M. and Court M.H. (2003)
456. Transcript profiling of cytochrome P450 genes in HL-60 human leukemic cells: upregulation of CYP1B1 by all-trans-retinoic acid. (PubMed id 12870655)⁹ Kawai M....Chang T.K. (2003)
457. Nuclear receptors orchestrate detoxification pathways . (PubMed id 12737794)⁹ Roy-Chowdhury J....Roy-Chowdhury N. (2003)
458. Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1. (PubMed id 12130634)⁹ Aarnisalo P....Perlmann T. (2002)
459. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. (PubMed id 12369894)⁹ Rushmore T.H. and Kong A.N. (2002)
460. Genomics and the prediction of xenobiotic toxicity. (PubMed id 12505353)⁹ Meyer U.A. and Gut J. (2002)
461. The calcimimetic agents: perspectives for treatment. (PubMed id 11982829)⁹ FrazALo J.M....Coburn J.W. (2002)
462. Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. (PubMed id 12469914)⁹ Ritter C.S....Brown A.J. (2002)
463. Insights from a three-dimensional model into ligand binding to constitutive active receptor. (PubMed id 12167558)⁹ Xiao L....Cheng K.C. (2002)
464. [Calcimimetics as a new chance for effective treatmen t of calcium metabolism disturbances] (PubMed id 12621766)⁹ Nowak Z. and LaudaA8ski K. (2002)
465. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. (PubMed id 12167569)⁹ El-Sankary W....Plant N. (2002)
466. Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C. (PubMed id 12356761)⁹ Young S.H....Rozengurt E. (2002)
467. L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? (PubMed id 12428172)⁹ Conigrave A.D....Quinn S.J. (2002)
468. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). (PubMed id 12383267)⁹ Jensen A.A....Brauner-Osborne H. (2002)
469. Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. (PubMed id 12021388)⁹ Ueda A....Sueyoshi T. (2002)
470. Regulation of hepatic drug metabolism: role of the nu clear receptors PXR and CAR. (PubMed id 12016543)⁹ Liddle C. and Goodwin B. (2002)
471. Complexities of glucuronidation affecting in vitro in vivo extrapolation. (PubMed id 12369890)⁹ Lin J.H. and Wong B.K. (2002)
472. [The role of nuclear receptors in cytochrome P-450 induction by xenochemicals] (PubMed id 12664659)⁹ Palut D....StruciA8ski P. (2002)
473. Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics. (PubMed id 11278292)⁹ Smirlis D....Shephard E.A. (2001)
474. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. (PubMed id 11560876)⁹ Drocourt L....Vilarem M.J. (2001)
475. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. (PubMed id 11264453)⁹ Sueyoshi T. and Negishi M. (2001)
476. Prevention of uremic bone disease using calcimimetic compounds. (PubMed id 11160775)⁹ Olgaard K. and Lewin E. (2001)
477. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. (PubMed id 11737189)⁹ Pascussi J.M....Vilarem M.J. (2001)
478. Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism. (PubMed id 11589681)⁹ Yamauchi M....Chihara K. (2001)
479. Activating mutations of the calcium-sensing receptor: management of hypocalcemia. (PubMed id 11701698)⁹ Lienhardt A....GarabAcdian M. (2001)
480. Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism. (PubMed id 11703583)⁹ VAolimAoki S....Farnebo L.O. (2001)
481. Comparative biosynthetic pathway of androstenol and androgens. (PubMed id 11457660)⁹ Dufort I....Luu-The V. (2001)
482. Induction of CYP2C genes in human hepatocytes in primary culture. (PubMed id 11181490)⁹ Gerbal-Chaloin S....Maurel P. (2001)
483. Pathophysiology of primary hyperparathyroidism. (PubMed id 10809383)⁹ Hellman P....AkerstrAPm G. (2000)
484. The calcium receptor modulates the hyperpolarization- activated current in subfornical organ neurons. (PubMed id 11043554)⁹ Washburn D.L....Ferguson A.V. (2000)
485. The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis. (PubMed id 10940344)⁹ Brown E.M. (2000)
486. First and second messenger role of calcium. Survival versus apoptosis in serum-free cultured granulosa explants. (PubMed id 11193025)⁹ Mussche S....D'Herde K. (2000)
487. Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium. (PubMed id 11192933)⁹ Wang D....Ferreri N.R. (2000)
488. Transcriptional control of hepatocanalicular transporter gene expression. (PubMed id 11076399)⁹ MA1ller M. (2000)
489. Parathyroid expression of calcium-sensing receptor protein and in vivo parathyroid hormone-Ca(2+) set-point in patients with primary hyperparathyroidism. (PubMed id 11134144)⁹ Cetani F....Marcocci C. (2000)
490. Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans. (PubMed id 10885586)⁹ Fuhr U. (2000)
491. Mutations in retinoid X receptor that impair heterodimerization with specific nuclear hormone receptor. (PubMed id 10948200)⁹ Lee S.K....Lee J.W. (2000)
492. Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium. (PubMed id 11033758)⁹ Brown E.M. (2000)
493. Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. (PubMed id 11075820)⁹ Kawamoto T....Negishi M. (2000)
494. Treatment of osteopenia secondary to primary hyperparathyroidism. (PubMed id 10915004)⁹ Yamaguchi T....Chihara K. (2000)
495. Biochemistry, physiology and pathophysiology of the extracellular calcium-sensing receptor. (PubMed id 10940638)⁹ Chattopadhyay N. (2000)
496. Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. (PubMed id 10642834)⁹ Chattopadhyay N....Brown E.M. (1999)
497. The extracellular calcium-sensing receptor: its role in health and disease. (PubMed id 9509247)⁹ Brown E.M....Hebert S.C. (1998)
498. Expression of extracellular calcium (Ca2+o)-sensing receptor in human peripheral blood monocytes. (PubMed id 9610391)⁹ Yamaguchi T....Brown E.M. (1998)
499. Calcium homeostasis and disorders of the calcium-sensing receptor. (PubMed id 9507434)⁹ Pearce S.H. (1998)
500. In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+-sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia. (PubMed id 9011580)⁹ Bai M....Steinmann B. (1997)
501. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. (PubMed id 8995751)⁹ Gogusev J....DrA1eke T.B. (1997)
502. Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor. (PubMed id 8702647)⁹ Bai M....Brown E.M. (1996)
503. Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium. (PubMed id 7721769)⁹ Caterina M.J....Hereld D. (1995)

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