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NR1I3 Gene

protein-coding   GIFtS: 63
GCID: GC01M161199

Nuclear Receptor Subfamily 1, Group I, Member 3

  See NR1I3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 1, Group I, Member 31 2     Constitutive Active Receptor2
Constitutive Androstane Receptor1 2 3     Constitutive Androstane Nuclear Receptor Variant 22
CAR2 3 5     Constitutive Androstane Nuclear Receptor Variant 32
Constitutive Activator Of Retinoid Response2 3     Constitutive Androstane Nuclear Receptor Variant 42
Constitutive Active Response2 3     Constitutive Androstane Nuclear Receptor Variant 52
Orphan Nuclear Receptor MB672 3     Nuclear Receptor Subfamily 1 Group I Member 32
MB672 5     Orphan Nuclear Hormone Receptor2
CAR12     

External Ids:    HGNC: 79691   Entrez Gene: 99702   Ensembl: ENSG000001432577   OMIM: 6038815   UniProtKB: Q149943   

Export aliases for NR1I3 gene to outside databases

Previous GC identifers: GC01M158910 GC01M156931 GC01M157978 GC01M158416 GC01M158012 GC01M159466 GC01M132556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR1I3 Gene:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and
endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and
regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as
cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively
active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in
translocation of this protein to the nucleus, where it activates or represses target gene transcription. These
ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NR1I3 Gene:
NR1I3 (nuclear receptor subfamily 1, group I, member 3) is a protein-coding gene. Diseases associated with NR1I3 include biliary tract disease, and acute porphyria. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic
acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element
module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

summary for NR1I3 Gene:
Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and
constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor
family. VDR is expressed in the intestine, thyroid and kidney.

Gene Wiki entry for NR1I3 (Constitutive androstane receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR1I3 gene promoter:
         AP-1   ATF-2   MEF-2   CRE-BP1   PPAR-alpha   CREB   MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR1I3 promoter sequence
   Search Chromatin IP Primers for NR1I3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR1I3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

NR1I3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1I3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161199:  view genomic region     (about GC identifiers)

Start:
161,199,456 bp from pter      End:
161,208,092 bp from pter
Size:
8,637 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 1 group I member 3  
Size: 352 amino acids; 39942 Da
Subunit: Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly
interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity)
2 PDB 3D structures from and Proteopedia for NR1I3:
1XV9 (3D)        1XVP (3D)    
Secondary accessions: E9PGH6 E9PH10 E9PHN4 F1D8Q0 F1D8Q1 Q0VAC9 Q4U0F0 Q5VTW5 Q5VTW6 Q6GZ68
Q6GZ77 Q6GZ78 Q6GZ83 Q6GZ84 Q6GZ85 Q6GZ87
Alternative splicing: 11 isoforms:  Q14994-1   Q14994-2   Q14994-3   Q14994-4   Q14994-5   Q14994-6   Q14994-7   Q14994-8   
Q14994-9   Q14994-10   Q14994-11   

Explore the universe of human proteins at neXtProt for NR1I3: NX_Q14994

Explore proteomics data for NR1I3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR1I3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_001070937.1  NP_001070938.1  NP_001070939.1  NP_001070940.1  NP_001070941.1  NP_001070942.1  NP_001070943.1  NP_001070944.1  
    NP_001070945.1  NP_001070946.1  NP_001070947.1  NP_001070948.1  NP_001070949.1  NP_001070950.1  NP_005113.1  

    ENSEMBL proteins: 
     ENSP00000425417   ENSP00000356962   ENSP00000407446   ENSP00000406493   ENSP00000399361  
     ENSP00000412672   ENSP00000424934   ENSP00000423666   ENSP00000356961   ENSP00000424834  
     ENSP00000422982   ENSP00000424345   ENSP00000427175   ENSP00000421374   ENSP00000423007  
     ENSP00000425607   ENSP00000356960   ENSP00000426016   ENSP00000421588   ENSP00000425900  
     ENSP00000426292   ENSP00000427600   ENSP00000356963   ENSP00000356965   ENSP00000356958  
     ENSP00000423089   ENSP00000427034   ENSP00000356959  
    Reactome Protein details: Q14994

    NR1I3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for OriGene Protein Over-expression Lysate for NR1I3 (NM_001077469  NM_001077469  NM_001077470  
        NM_001077470  )
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NR1I3 

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    Search eBioscience for ELISAs for NR1I3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Constitutive androstane receptor
    1I. Vitamin D receptor-like receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14994

    ProtoNet protein and cluster: Q14994

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
    Domain: Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization
    domains
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR1I3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR1I3_HUMAN, Q14994
    Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic
    acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element
    module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element
    Induction: By dexamethasone

         Genatlas biochemistry entry for NR1I3:
    nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several
    isoforms

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9783588
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8020947
    GO:0003707steroid hormone receptor activity ----
    GO:0003713transcription coactivator activity TAS9783588
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS8114692
         
    Find genes that share ontologies with NR1I3           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nr1i3):
     cellular  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with NR1I3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NR1I3: Nr1i3tm1.1Arte Nr1i3tm1Dgen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR1I3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR1I3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR1I3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR1I3

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 15): NR1I3 (NM_001077480)
    Sino Biological Human cDNA Clone for NR1I3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR1I3_HUMAN, Q14994: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7 (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with NR1I3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR1I3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Selected targets of GCR alpha
    Selected targets of GCR alpha
    4Nuclear receptors in lipid metabolism and toxicity
    Nuclear receptors in lipid metabolism and toxicity
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    Find genes that share SuperPaths with NR1I3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for NR1I3
        Nuclear Receptors
    Nuclear receptors in lipid metabolism and toxicity
    Drug Induction of Bile Acid Pathway
    Glucocorticoid receptor regulatory network


    1 Reactome Pathway for NR1I3
        Nuclear Receptor transcription pathway

    1 PharmGKB Pathway for NR1I3
        Carbamazepine Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Array including NR1I3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR1I3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NR1I3 (Q149943 ENSP000003569594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    PPARGC1AQ9UBK23, ENSP000002648674I2D: score=1 STRING: ENSP00000264867
    RXRAP197933, ENSP000004196924I2D: score=2 STRING: ENSP00000419692
    NCOA1Q157883, ENSP000003209404I2D: score=2 STRING: ENSP00000320940
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS8020947
    GO:0010467gene expression TAS--

    Find genes that share ontologies with NR1I3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NR1I3
      Browse compounds at ApexBio 

    Compounds for NR1I3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    EB 1089Vitamin D receptor (VDR) agonist[134404-52-7]
    CalcipotriolVitamin D3 analog[112965-21-6]
    AlfacalcidolProdrug of vitamin D3 (Cat. No. 4156)[41294-56-8]
    CalcifediolProhormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D[19356-17-3]
    CalcitriolVitamin D receptor (VDR) agonist[32222-06-3]

    7 HMDB Compounds for NR1I3    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    2 DrugBank Compounds for NR1I3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5BETA)-PREGNANE-3,20-DIONE-- --target--10592235
    16,17-Androstene-3-Ol-- 7148-51-8target--10592235

    4 IUPHAR Ligands for NR1I3 (Constitutive androstane receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    CITCO
    AgonistAgonist7.312611900
    meclizine
    AntagonistAntagonist7.1615272053
    pregnanedione
    AgonistAgonist6.1710748001
    clotrimazole
    AntagonistAntagonist6.1610748001

    Selected Novoseek inferred chemical compound relationships for NR1I3 gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    androstane 99.2 707 11518807 (4), 12644700 (3), 16635107 (3), 11093784 (2) (see all 99)
    citco 97.5 23 19588937 (2), 16099843 (1), 16929008 (1), 18332083 (1) (see all 10)
    androstanol 91.6 12 15905360 (1), 16929008 (1), 17483497 (1), 18474683 (1) (see all 9)
    tcpobop 87.4 34 15563456 (4), 16101572 (3), 18798339 (3), 18441373 (2) (see all 10)
    androstenol 85 8 11457660 (3), 16929008 (1), 12114525 (1), 9783588 (1) (see all 5)
    phenobarbital 82.5 133 19920082 (5), 10993889 (5), 17904175 (5), 11113125 (3) (see all 48)
    dmes 82.4 14 19034627 (2), 16918318 (1), 18537574 (1), 19695866 (1) (see all 5)
    cinacalcet 78.2 16 16189180 (4), 14696958 (2), 15794735 (1), 17373205 (1) (see all 7)
    rifampicin 73.7 31 18786598 (3), 15919766 (3), 11181490 (2), 19588937 (2) (see all 16)
    metofluthrin 72.1 3 19378387 (1), 19176367 (1)



    Find genes that share compounds with NR1I3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NR1I3 gene (15 alternative transcripts): 
    NM_001077469.2  NM_001077470.2  NM_001077471.2  NM_001077472.2  NM_001077473.2  NM_001077474.2  NM_001077475.2  NM_001077476.2  
    NM_001077477.2  NM_001077478.2  NM_001077479.2  NM_001077480.2  NM_001077481.2  NM_001077482.2  NM_005122.4  

    Unigene Cluster for NR1I3:

    Nuclear receptor subfamily 1, group I, member 3
    Hs.349642  [show with all ESTs]
    Unigene Representative Sequence: AK303757
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000512372 ENST00000367983(uc001fzy.3) ENST00000488651 ENST00000464422
    ENST00000437437 ENST00000479324 ENST00000442691 ENST00000412844 ENST00000428574
    ENST00000505005 ENST00000508740 ENST00000367982 ENST00000506018 ENST00000508387
    ENST00000504010 ENST00000511676 ENST00000502985 ENST00000512340
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      QuantiTect SYBR Green Assays in human, mouse, rat NR1I3
      QuantiFast Probe-based Assays in human, mouse, rat NR1I3

    Additional mRNA sequence: 

    AB307702.1 AK303757.1 AK303796.1 AK310773.1 AK316208.1 AY572806.1 AY572808.1 AY572810.1 
    AY572811.1 AY572812.1 AY572813.1 AY572816.1 AY572817.1 AY572818.1 AY572819.1 AY572820.1 
    AY572821.1 AY572822.1 AY572823.1 AY572824.1 AY572825.1 AY572827.1 BC069626.1 BC121120.1 
    BC121121.1 DQ022681.1 HQ692838.1 HQ692839.1 HQ692840.1 HQ692841.1 HQ709178.1 

    14 DOTS entries:

    DT.121424716  DT.118470  DT.95212776  DT.75101308  DT.121424516  DT.121424730  DT.121424744  DT.121424507 
    DT.121424513  DT.121424575  DT.91855775  DT.75170204  DT.91931603  DT.97809200 

    Selected AceView cDNA sequences (see all 70):

    AI262949 AY572825 AY572811 AY572816 BC069651 CB157668 AY572820 AW275372 
    AY572807 BM719939 AY572821 AY572818 AY572824 AV661397 AY572806 AY572815 
    AY572826 AY572810 AY572809 AY572819 AV652750 AV652691 AY572812 AY572823 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NR1I3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                              -           -         
    SP2:                                                  -                       -         
    SP3:                                                  -     -     -           -         
    SP4:        -     -                                                           -         
    SP5:        -     -                                   -                       -         


    ECgene alternative splicing isoforms for NR1I3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NR1I3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCTTCT
    NR1I3 Expression
    About this image


    NR1I3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Perivenous Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
    NR1I3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR1I3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.349642

    UniProtKB/Swiss-Prot: NR1I3_HUMAN, Q14994
    Tissue specificity: Predominantly expressed in liver

        Pathway & Disease-focused RT2 Profiler PCR Array including NR1I3: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NR1I3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr1i31 , 5 nuclear receptor subfamily 1, group I, member 31, 5 80.75(n)1
    74.71(a)1
      1 (79.21 cM)5
    123551  NM_009803.51  NP_033933.21 
     1712139705 
    chicken
    (Gallus gallus)
    Aves NR1I31 nuclear receptor subfamily 1, group I, member 3 62.5(n)
    57.56(a)
      395439  NM_204702.1  NP_990033.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR1I36
    nuclear receptor subfamily 1, group I, member 3
    40(a)
    1 ↔ 1
    AAWZ02038821(3457-10280)
    fruit fly
    (Drosophila melanogaster)
    Insecta EcR6
    Ecdysone receptor
    12(a)
    1 → many
    2R(1975378-2056592)


    ENSEMBL Gene Tree for NR1I3 (if available)
    TreeFam Gene Tree for NR1I3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR1I3 gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    NR1D22  RARB2  RORA2  RORB2  RORC2  NR1D12  PPARG2  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for NR1I3 using alignment to 22 protein entries:     NR1I3_HUMAN (see all proteins) (see all similar genes):
    THRB    NR3C2    HNF4alpha    NR3C4    AR    VDR
    ESR2    NR5A2    ERRgamma    ESRRG    RXRB    NR3C1
    RORA    ESR1    NR1C3    NR4A1    PPARG    NR2A2

    Find genes that share paralogs with NR1I3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR1I3 (see all 364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999489711,2
    --132560554(+) ATATA-/TATG  
            
    TGTGT
    15 -- int10--------
    rs1121684381,2
    C,F--161202024(+) ACCCAG/CCTTGG 15 -- int11Minor allele frequency- C:0.50WA 2
    rs30035931,2
    C,H--161203627(+) TATAtA/Gtgtgt 15 -- int10--------
    rs112655691,2
    C,A,H--161203669(+) tgtgtA/Gtgtgt 15 -- int10--------
    rs124026561,2
    A,H--161203675(+) tgtgtA/GtGtat 15 -- int10--------
    rs1130937111,2
    C--161206516(+) TGTGG-/TTTTCT
            
    TTTTC
    15 -- cds11Minor allele frequency- TTTTCT:0.50CSA 2
    rs347950241,2
    C--161208668(+) AAAAAA/-GAGAG 15 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1117813521,2
    C,F--167695278(+) GCCCTC/TCTCAG 15 -- ds50013Minor allele frequency- T:0.14CSA WA 122
    rs1505439621,2
    C--167695425(+) CCCCCA/GGCACC 15 -- ds50010--------
    rs359371391,2
    C--167695639(-) GAAGCA/TCAGAA 15 -- ds50011Minor allele frequency- T:0.01--194

    HapMap Linkage Disequilibrium report for NR1I3 (161199456 - 161208092 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NR1I3: --
    Human Gene Mutation Database (HGMD): NR1I3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR1I3
    DNA2.0 Custom Variant and Variant Library Synthesis for NR1I3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603881    OMIM disorders: --

    10 diseases for NR1I3:    
    About MalaCards
    biliary tract disease    acute porphyria    familial hypocalciuric hypercalcemia    humoral hypercalcemia of malignancy
    uremia    primary hyperparathyroidism    intrahepatic cholestasis of pregnancy    hypercalcemia
    hyperparathyroidism    cholestasis

    3 diseases from the University of Copenhagen DISEASES database for NR1I3:
    Cholestasis     Bilirubin metabolic disorder     Neonatal jaundice

    Find genes that share disorders with NR1I3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NR1I3 gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperparathyroidism secondary 73.2 15 16189180 (2), 11033758 (1), 16919492 (1), 12830754 (1) (see all 13)
    nshpt 61.3 3 11033758 (1), 9507434 (1)
    hyperparathyroidism 60.1 11 15658669 (2), 8675635 (1), 17018434 (1), 9011580 (1) (see all 9)
    hypercalcemia 58.6 22 11033758 (2), 16189180 (2), 16603723 (2), 18492387 (1) (see all 9)
    hyperparathyroidism primary 57.2 11 11134144 (2), 16189180 (2), 8675635 (1), 9509247 (1) (see all 5)
    parathyroid hyperplasia 54.9 4 12469914 (2), 15888568 (1)
    cholestasis 54.4 8 16565602 (2), 16101572 (1), 19300246 (1), 16025508 (1) (see all 5)
    hypocalcemia 48.2 5 15507543 (1), 17018434 (1), 9757371 (1), 11701698 (1)
    hypoparathyroidism 43.9 10 11701698 (3), 12940896 (1), 9757371 (1), 9768650 (1) (see all 7)
    jaundice neonatal 43.5 3 12644704 (1), 19925451 (1)

    Genetic Association Database (GAD): NR1I3
    Human Genome Epidemiology (HuGE) Navigator: NR1I3 (7 documents)

    Export disorders for NR1I3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR1I3 gene, integrated from 10 sources (see all 517):
    (articles sorted by number of sources associating them with NR1I3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PubMed id 8114692)1, 2, 3 Baes M.... Moore D.D. (Mol. Cell. Biol. 1994)
    2. Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PubMed id 19858220)1, 2, 9 Mutoh S.... Negishi M. (J. Biol. Chem. 2009)
    3. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PubMed id 15194709)1, 2, 9 Lamba J.K.... Schuetz E.G. (J. Pharmacol. Exp. Ther. 2004)
    4. PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients. (PubMed id 17876342)1, 4, 9 Hor S.Y....Tan T. (Pharmacogenomics J. 2008)
    5. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PubMed id 18056193)1, 4, 9 Tham L.S....Goh B.C. (Clin. Cancer Res. 2007)
    6. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. (PubMed id 15610735)1, 2, 9 Xu R.X....Moore J.T. (Mol. Cell 2004)
    7. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. (PubMed id 18294295)1, 4 Kiyotani K....Nakamura Y. (Cancer Sci. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. (PubMed id 15618763)1, 2 Ikeda S.... Sawada J. (Drug Metab. Pharmacokinet. 2003)
    10. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. (PubMed id 8603043)1, 2 Choi H.S.... Moore D.D. (J. Steroid Biochem. Mol. Biol. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9970 HGNC: 7969 AceView: NR1I3 Ensembl:ENSG00000143257 euGenes: HUgn9970
    ECgene: NR1I3 H-InvDB: NR1I3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NR1I3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NR1I3 gene:
    Search GeneIP for patents involving NR1I3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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