Aliases for NR1I3 Gene
Aliases for NR1I3 Gene
- Nuclear Receptor Subfamily 1 Group I Member 3 2 3 5
- Constitutive Androstane Receptor 2 3 4
- Constitutive Activator Of Retinoid Response 3 4
- Constitutive Active Response 3 4
- Orphan Nuclear Receptor MB67 3 4
- CAR 3 4
- Constitutive Androstane Nuclear Receptor Variant 2 3
- Constitutive Androstane Nuclear Receptor Variant 3 3
External Ids for NR1I3 Gene
- HGNC: 7969
- Entrez Gene: 9970
- Ensembl: ENSG00000143257
- OMIM: 603881
- UniProtKB: Q14994
Previous GeneCards Identifiers for NR1I3 Gene
- GC01M158910
- GC01M156931
- GC01M157978
- GC01M158416
- GC01M158012
- GC01M159466
- GC01M132556
Summaries for NR1I3 Gene
-
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NR1I3 Gene
NR1I3 (Nuclear Receptor Subfamily 1 Group I Member 3) is a Protein Coding gene. Diseases associated with NR1I3 include Biliary Tract Disease and Hyperparathyroidism, Neonatal Severe. Among its related pathways are Gene Expression and Constitutive Androstane Receptor Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NR1I2.
UniProtKB/Swiss-Prot for NR1I3 Gene
-
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
-
Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with retinoid X receptor family members, and are expressed in the intestine, thyroid and kidney.
Additional gene information for NR1I3 Gene
- Monarch Initiative
- Search for NR1I3 at DataMed
- Search for NR1I3 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1I3 Gene
Genomics for NR1I3 Gene
GeneHancer (GH) Regulatory Elements for NR1I3 Gene
- Top Transcription factor binding sites by QIAGEN in the NR1I3 gene promoter:
Regulatory Element Products
Genomic Locations for NR1I3 Gene
- chr1:161,229,666-161,238,598
- (GRCh38/hg38)
- Size:
- 8,933 bases
- Orientation:
- Minus strand
- chr1:161,199,456-161,208,092
- (GRCh37/hg19)
Genomic View for NR1I3 Gene
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC


RefSeq DNA sequence for NR1I3 Gene
Proteins for NR1I3 Gene
-
Protein details for NR1I3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14994-NR1I3_HUMAN
- Recommended name:
- Nuclear receptor subfamily 1 group I member 3
- Protein Accession:
- Q14994
- E9PB75
- E9PC13
- E9PDU3
- E9PGH6
- E9PH10
- E9PHC8
- E9PHN4
- F1D8Q0
- F1D8Q1
- Q0VAC9
- Q4U0F0
- Q5VTW5
- Q5VTW6
- Q6GZ68
- Q6GZ76
- Q6GZ77
- Q6GZ78
- Q6GZ79
- Q6GZ82
- Q6GZ83
- Q6GZ84
- Q6GZ85
- Q6GZ87
- Q6GZ89
Protein attributes for NR1I3 Gene
- Size:
- 352 amino acids
- Molecular mass:
- 39942 Da
- Quaternary structure:
-
- Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).
Protein Expression for NR1I3 Gene
Post-translational modifications for NR1I3 Gene
- Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Other Protein References for NR1I3 Gene
- ENSEMBL proteins:
-
- ENSP00000356959
- ENSP00000356960
- ENSP00000356961
- ENSP00000356962
- ENSP00000356963
- ENSP00000356965
- ENSP00000399361
- ENSP00000406493
- ENSP00000407446
- ENSP00000412672
- ENSP00000421374
- ENSP00000421588
- ENSP00000422982
- ENSP00000423007
- ENSP00000423089
- ENSP00000423666
- ENSP00000424345
- ENSP00000424834
- ENSP00000424934
- ENSP00000425417
- ENSP00000425607
- ENSP00000425900
- ENSP00000426016
- ENSP00000426292
- ENSP00000427034
- ENSP00000427175
- ENSP00000427600
- ENSP00000487337
- ENSP00000356958
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NR1I3 (CAR/NR1I3)
- Novus Biologicals Antibodies for NR1I3
-
Abcam antibodies for NR1I3
- Invitrogen Antibodies for NR1I3
- GeneTex NR1I3 antibody for NR1I3
Protein Products
-
OriGene Purified Proteins for NR1I3
- NM_001077482
- NM_001077474
- NM_001077482
- NM_001077481
- NM_001077479
- NM_001077478
- NM_001077477
- NM_001077476
- NM_001077475
- NM_001077473
- NM_001077472
- NM_001077470
- NM_001077469
- NM_001077482
- NM_001077481
- NM_001077479
- NM_001077478
- NM_001077477
- NM_001077476
- NM_001077475
- NM_001077473
- NM_001077472
- NM_001077471
- NM_001077470
- NM_001077469
- NM_005122
- Search Origene for MassSpec and Protein Over-expression Lysates for NR1I3
- Origene Custom Protein Services for NR1I3
- Search GeneTex for Proteins for NR1I3
-
Abcam proteins for NR1I3
Assay Products
-
Cloud-Clone Corp. Assay Kits for NR1I3
No data available for DME Specific Peptides for NR1I3 Gene
Domains & Families for NR1I3 Gene
Gene Families for NR1I3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Nuclear receptors
- Predicted intracellular proteins
- Transcription factors
Protein Domains for NR1I3 Gene
Suggested Antigen Peptide Sequences for NR1I3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14994UniProtKB/Swiss-Prot:
NR1I3_HUMAN :- Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
- Belongs to the nuclear hormone receptor family. NR1 subfamily.
- Domain:
-
- Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
- Family:
-
- Belongs to the nuclear hormone receptor family. NR1 subfamily.
Function for NR1I3 Gene
Molecular function for NR1I3 Gene
- GENATLAS Biochemistry:
- nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several isoforms
- UniProtKB/Swiss-Prot Function:
- Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
- UniProtKB/Swiss-Prot Induction:
- By dexamethasone.
Phenotypes From GWAS Catalog for NR1I3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 11114890 |
GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 11114890 |
GO:0003677 | DNA binding | TAS,IEA | 9783588 |
GO:0003700 | DNA binding transcription factor activity | TAS,IEA | 8020947 |
GO:0003707 | steroid hormone receptor activity | IEA | -- |
Phenotypes for NR1I3 Gene
- MGI mutant phenotypes for NR1I3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NR1I3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased shRNA abundance
Animal Models for NR1I3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR1I3
-
- Search ViGene Biosciences for NR1I3
CRISPR Products
-
OriGene CRISPR knockouts for NR1I3
- genomics-online: gRNA clones - Search results for available NR1I3 gene related products
- Applied Biological Materials CRISPR for NR1I3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
miRNA for NR1I3 Gene
- miRTarBase miRNAs that target NR1I3
miRNA Products
- Search ViGene Biosciences for NR1I3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NR1I3
- Browse OriGene Inhibitory RNA Products For NR1I3
- genomics-online: shRNA clones - Search results for available NR1I3 gene related products
Clone Products
-
OriGene ORF clones in human for NR1I3
- RC216643L1V
- RC216643L2V
- RC213288L1V
- RC213288L2V
- RC216702L1V
- RC216702L2V
- RC216757L1V
- RC216757L2V
- RC213453L1V
- RC213453L2V
- RC216817L1V
- RC216817L2V
- RC216880L1V
- RC216880L2V
- RC213613L1V
- RC213613L2V
- RC216922L1V
- RC216922L2V
- RC216983L1V
- RC216983L2V
- RC213751L1V
- RC213751L2V
- RC210209L1V
- RC210209L2V
- RC213852L1V
- RC213852L2V
- RC213905L1V
- RC213905L2V
- RC216592L1V
- RC216592L2V
- RC216643
- RC216643L1
- RC216643L2
- RG216643
- RC213288
- RC213288L1
- RC213288L2
- RG216592
- RC216592L2
- RC216592L1
- RC216592
- RG213905
- RC213905L2
- RC213905L1
- RC213905
- RG213852
- RC213852L2
- RC213852L1
- RC213852
- RG210209
- RC210209L2
- RC210209L1
- RC210209
- RG213751
- RC213751L2
- RC213751L1
- RC213751
- RG216983
- RC216983L2
- RC216983L1
- RC216983
- RG216922
- RC216922L2
- RC216922L1
- RC216922
- RG213613
- RC213613L2
- RC213613L1
- RC213613
- RG216880
- RC216880L2
- RC216880L1
- RC216880
- RG216817
- RC216817L2
- RC216817L1
- RC216817
- RG213453
- RC213453L2
- RC213453L1
- RC213453
- RG216757
- RC216757L2
- RC216757L1
- RC216757
- RG216702
- RC216702L2
- RC216702L1
- RC216702
- RG213288
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR1I3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NR1I3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR1I3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NR1I3 gene related products
- orf clones - Search results for available NR1I3 gene related products
- Applied Biological Materials Clones for NR1I3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NR1I3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR1I3 Gene
Localization for NR1I3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR1I3 Gene
- Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | ISS | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for NR1I3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Nuclear Receptor transcription pathway | ||
3 | Phenytoin Pathway, Pharmacokinetics | ||
4 | Tamoxifen Pathway, Pharmacokinetics | ||
5 | Constitutive Androstane Receptor Pathway |
Pathways by source for NR1I3 Gene
5 BioSystems pathways for NR1I3 Gene
3 Reactome pathways for NR1I3 Gene
2 PharmGKB pathways for NR1I3 Gene
Interacting Proteins for NR1I3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0007165 | signal transduction | TAS | 8020947 |
GO:0030521 | androgen receptor signaling pathway | IEA | -- |
Drugs & Compounds for NR1I3 Gene
(69) Drugs for NR1I3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Clotrimazole | Approved, Vet_approved | Pharma | Inhibition, Pore Blocker, Target, partial agonist, inhibitor | 38 | ||
Meclizine | Approved | Pharma | Antagonist, Target, inverse agonist, modulator | 7 | ||
cholesterol | Approved, Experimental, Investigational | Pharma | Agonist, Target | 0 | ||
Doxylamine | Approved, Vet_approved | Pharma | Target | 7,7 | ||
Ketoconazole | Approved, Investigational | Pharma | Pore Blocker, Target | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor | 179 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Androstenol |
|
1153-51-1 | ||||
1-Hexanol |
|
111-27-3 |
|
|||
1-Pentanol |
|
71-41-0 |
|
|||
Isobutanol |
|
78-83-1 |
|
|||
CINPA 1 |
|
102636-74-8 |
|
|
(4) Tocris Compounds for NR1I3 Gene
(4) ApexBio Compounds for NR1I3 Gene
Compound | Action | Cas Number |
---|---|---|
Fexaramine | 574013-66-4 | |
GW3965 | HLXRα/hLXRβ agonist,potent and selective | 405911-09-3 |
LXR-623 | Liver X-receptor agonist | 875787-07-8 |
SR-9243 | inverse agonist of LXR | 1613028-81-1 |
Transcripts for NR1I3 Gene
mRNA/cDNA for NR1I3 Gene
- (19) REFSEQ mRNAs :
- (31) Additional mRNA sequences :
- (70) Selected AceView cDNA sequences:
- (35) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NR1I3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NR1I3
- genomics-online: gRNA clones - Search results for available NR1I3 gene related products
- Applied Biological Materials CRISPR for NR1I3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
miRNA Products
- Search ViGene Biosciences for NR1I3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NR1I3
- Browse OriGene Inhibitory RNA Products For NR1I3
- genomics-online: shRNA clones - Search results for available NR1I3 gene related products
Clone Products
-
OriGene ORF clones in human for NR1I3
- RC216643L1V
- RC216643L2V
- RC213288L1V
- RC213288L2V
- RC216702L1V
- RC216702L2V
- RC216757L1V
- RC216757L2V
- RC213453L1V
- RC213453L2V
- RC216817L1V
- RC216817L2V
- RC216880L1V
- RC216880L2V
- RC213613L1V
- RC213613L2V
- RC216922L1V
- RC216922L2V
- RC216983L1V
- RC216983L2V
- RC213751L1V
- RC213751L2V
- RC210209L1V
- RC210209L2V
- RC213852L1V
- RC213852L2V
- RC213905L1V
- RC213905L2V
- RC216592L1V
- RC216592L2V
- RC216643
- RC216643L1
- RC216643L2
- RG216643
- RC213288
- RC213288L1
- RC213288L2
- RG216592
- RC216592L2
- RC216592L1
- RC216592
- RG213905
- RC213905L2
- RC213905L1
- RC213905
- RG213852
- RC213852L2
- RC213852L1
- RC213852
- RG210209
- RC210209L2
- RC210209L1
- RC210209
- RG213751
- RC213751L2
- RC213751L1
- RC213751
- RG216983
- RC216983L2
- RC216983L1
- RC216983
- RG216922
- RC216922L2
- RC216922L1
- RC216922
- RG213613
- RC213613L2
- RC213613L1
- RC213613
- RG216880
- RC216880L2
- RC216880L1
- RC216880
- RG216817
- RC216817L2
- RC216817L1
- RC216817
- RG213453
- RC213453L2
- RC213453L1
- RC213453
- RG216757
- RC216757L2
- RC216757L1
- RC216757
- RG216702
- RC216702L2
- RC216702L1
- RC216702
- RG213288
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR1I3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NR1I3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR1I3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NR1I3 gene related products
- orf clones - Search results for available NR1I3 gene related products
- Applied Biological Materials Clones for NR1I3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||
SP9: | - | - | - | - | - | - | |||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | ||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | |||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - |
Expression for NR1I3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for NR1I3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR1I3 Gene
NURSA nuclear receptor signaling pathways regulating expression of NR1I3 Gene:
NR1I3SOURCE GeneReport for Unigene cluster for NR1I3 Gene:
Hs.349642mRNA Expression by UniProt/SwissProt for NR1I3 Gene:
Q14994-NR1I3_HUMANEvidence on tissue expression from TISSUES for NR1I3 Gene
- Liver(4.8)
- Intestine(4.4)
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for NR1I3
-
OriGene qPCR primer pairs and template standards for NR1I3
- genomics-online: primer clones - Search results for available NR1I3 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NR1I3 Gene
Orthologs for NR1I3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NR1I3 34 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | NR1I3 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NR1I3 33 |
|
||
CAR 34 |
|
OneToOne | |||
rat (Rattus norvegicus) |
Mammalia | Nr1i3 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nr1i3 34 16 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | NR1I3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NR1I3 34 33 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | NR1I3 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | EcR 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NR1I3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NR1I3 Gene
(57) SIMAP similar genes for NR1I3 Gene using alignment to 22 proteins:
- THRB
- NR3C2
- HNF4alpha
- NR3C4
- AR
- VDR
- ESR2
- NR5A2
- RXRB
- ESRRG
- ERRgamma
- NR3C1
- RORA
- ESR1
- PPARG
- NR4A1
- NR1C3
- NR2A2
- NR3B3
- NR2A3
- NR2C2
- NR5A1
- ESRRB
- THRA
- NR4A2
- HNF4G
- NR1F2
- RORB
- NR1F1
- NR2C1
- RORC
- NR2A1
- NR1F3
- NR1H2
- NR2F6
- NR1A2
- NR1D2
- NR1H3
- DKFZp761C0417
- RXRA
- NR2B3
- NR1H4
- DKFZp686P04237
- NR1I2
- NR2F1
- NR1B2
- RARB
- NR1B1
- NR1I1
- NR2E1
- RARA
- BCOR-RARA
- NR1A1
- NR6A1
- NR1i2
- NR1i1
- DKFZp686D1580
Variants for NR1I3 Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs398122411 | uncertain-significance, Chromosome 9q deletion syndrome | 161,231,200(-) | A/G | coding_sequence_variant, intron_variant, missense_variant | |
rs148277311 | likely-benign, not specified | 161,235,903(-) | C/T | coding_sequence_variant, missense_variant | |
rs35205211 | likely-benign, not specified | 161,233,319(-) | G/C | coding_sequence_variant, synonymous_variant | |
rs143067018 | uncertain-significance, not specified | 161,232,814(-) | C/T | coding_sequence_variant, missense_variant | |
rs150124500 | uncertain-significance, not specified | 161,229,905(-) | T/G | coding_sequence_variant, intron_variant, synonymous_variant |
Additional Variant Information for NR1I3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR1I3 Gene
Disorders for NR1I3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
biliary tract disease |
|
|
hyperparathyroidism, neonatal severe |
|
|
intrahepatic cholestasis |
|
|
neonatal jaundice |
|
|
cholestasis |
|
Additional Disease Information for NR1I3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NR1I3 Gene
Publications for NR1I3 Gene
- Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PMID: 19858220) Mutoh S … Negishi M (The Journal of biological chemistry 2009) 3 4 22 58
- Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PMID: 18056193) Tham LS … Goh BC (Clinical cancer research : an official journal of the American Association for Cancer Research 2007) 3 22 44 58
- Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PMID: 15194709) Lamba JK … Schuetz E (The Journal of pharmacology and experimental therapeutics 2004) 3 4 22 58
- A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PMID: 8114692) Baes M … Moore DD (Molecular and cellular biology 1994) 2 3 4 58
- Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (PMID: 19682433) Yoshinari K … Yamazoe Y (Biochemical pharmacology 2010) 3 22 58
Products for NR1I3 Gene
- R&D Systems Antibodies for NR1I3 (CAR/NR1I3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NR1I3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NR1I3
- NM_005122
- NM_001077469
- NM_001077470
- NM_001077471
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- NM_001077469
- NM_001077470
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- NM_001077474
- NM_001077482
- Search Origene for MassSpec and Protein Over-expression Lysates for NR1I3
- Origene Custom Protein Services for NR1I3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NR1I3
- Browse OriGene Inhibitory RNA Products For NR1I3
- OriGene qPCR primer pairs and template standards for NR1I3
- OriGene qPCR primer pairs for NR1I3
- OriGene CRISPR knockouts for NR1I3
- OriGene ORF clones in human for NR1I3
- RC216643L1V
- RC216643L2V
- RC213288L1V
- RC213288L2V
- RC216702L1V
- RC216702L2V
- RC216757L1V
- RC216757L2V
- RC213453L1V
- RC213453L2V
- RC216817L1V
- RC216817L2V
- RC216880L1V
- RC216880L2V
- RC213613L1V
- RC213613L2V
- RC216922L1V
- RC216922L2V
- RC216983L1V
- RC216983L2V
- RC213751L1V
- RC213751L2V
- RC210209L1V
- RC210209L2V
- RC213852L1V
- RC213852L2V
- RC213905L1V
- RC213905L2V
- RC216592L1V
- RC216592L2V
- RC216643
- RC216643L1
- RC216643L2
- RG216643
- RC213288
- RC213288L1
- RC213288L2
- RG213288
- RC216702
- RC216702L1
- RC216702L2
- RG216702
- RC216757
- RC216757L1
- RC216757L2
- RG216757
- RC213453
- RC213453L1
- RC213453L2
- RG213453
- RC216817
- RC216817L1
- RC216817L2
- RG216817
- RC216880
- RC216880L1
- RC216880L2
- RG216880
- RC213613
- RC213613L1
- RC213613L2
- RG213613
- RC216922
- RC216922L1
- RC216922L2
- RG216922
- RC216983
- RC216983L1
- RC216983L2
- RG216983
- RC213751
- RC213751L1
- RC213751L2
- RG213751
- RC210209
- RC210209L1
- RC210209L2
- RG210209
- RC213852
- RC213852L1
- RC213852L2
- RG213852
- RC213905
- RC213905L1
- RC213905L2
- RG213905
- RC216592
- RC216592L1
- RC216592L2
- RG216592
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NR1I3
- GenScript: Next-day shipping of latest version cDNA ORF clones for NR1I3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NR1I3
- GenScript Custom Assay Services for NR1I3
- GenScript Custom overexpressing Cell Line Services for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NR1I3
- Sino Biological Human cDNA Clone for NR1I3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NR1I3
- Novus Biologicals proteins and lysates for NR1I3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NR1I3
- Abcam proteins for NR1I3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for NR1I3
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NR1I3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for NR1I3
- Cyagen custom Knockout/knockin (KOKI) mouse models for NR1I3
- VectorBuilder custom plasmid, inducible vectors for NR1I3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NR1I3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 118 available NR1I3 Antibodies ranked by validation data
- Compare Top NR1I3 Antibodies
- antibodies-online: Search results for 17 available NR1I3 Elisa Kits ranked by validation data
- Compare Top NR1I3 Elisa Kits
- antibodies-online: Search results for 18 available NR1I3 Proteins ranked by validation data
- Compare Top NR1I3 Proteins
- GeneTex NR1I3 antibody for NR1I3
- Search GeneTex for Proteins for NR1I3
- genomics-online: cdna clones - Search results for available NR1I3 gene related products
- orf clones - Search results for available NR1I3 gene related products
- genomics-online: gRNA clones - Search results for available NR1I3 gene related products
- genomics-online: primer clones - Search results for available NR1I3 gene related products
- genomics-online: shRNA clones - Search results for available NR1I3 gene related products
Sources for NR1I3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew