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Aliases for NR1I3 Gene

Aliases for NR1I3 Gene

  • Nuclear Receptor Subfamily 1, Group I, Member 3 2 3
  • Constitutive Androstane Receptor 2 3 4
  • CAR 3 4 6
  • Constitutive Activator Of Retinoid Response 3 4
  • Constitutive Active Response 3 4
  • Orphan Nuclear Receptor MB67 3 4
  • MB67 3 6
  • Constitutive Androstane Nuclear Receptor Variant 2 3
  • Constitutive Androstane Nuclear Receptor Variant 3 3
  • Constitutive Androstane Nuclear Receptor Variant 4 3
  • Constitutive Androstane Nuclear Receptor Variant 5 3
  • Nuclear Receptor Subfamily 1 Group I Member 3 3
  • Orphan Nuclear Hormone Receptor 3
  • Constitutive Active Receptor 3
  • CAR1 3

External Ids for NR1I3 Gene

Previous GeneCards Identifiers for NR1I3 Gene

  • GC01M158910
  • GC01M156931
  • GC01M157978
  • GC01M158416
  • GC01M158012
  • GC01M159466
  • GC01M132556

Summaries for NR1I3 Gene

Entrez Gene Summary for NR1I3 Gene

  • This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR1I3 Gene

NR1I3 (Nuclear Receptor Subfamily 1, Group I, Member 3) is a Protein Coding gene. Diseases associated with NR1I3 include biliary tract disease and acute porphyria. Among its related pathways are Glucocorticoid receptor regulatory network and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for NR1I3 Gene

  • Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

Tocris Summary for NR1I3 Gene

  • Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney

Gene Wiki entry for NR1I3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1I3 Gene

Genomics for NR1I3 Gene

Regulatory Elements for NR1I3 Gene

Genomic Location for NR1I3 Gene

Start:
161,229,666 bp from pter
End:
161,238,642 bp from pter
Size:
8,977 bases
Orientation:
Minus strand

Genomic View for NR1I3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR1I3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1I3 Gene

Proteins for NR1I3 Gene

  • Protein details for NR1I3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14994-NR1I3_HUMAN
    Recommended name:
    Nuclear receptor subfamily 1 group I member 3
    Protein Accession:
    Q14994
    Secondary Accessions:
    • E9PB75
    • E9PC13
    • E9PDU3
    • E9PGH6
    • E9PH10
    • E9PHC8
    • E9PHN4
    • F1D8Q0
    • F1D8Q1
    • Q0VAC9
    • Q4U0F0
    • Q5VTW5
    • Q5VTW6
    • Q6GZ68
    • Q6GZ76
    • Q6GZ77
    • Q6GZ78
    • Q6GZ79
    • Q6GZ82
    • Q6GZ83
    • Q6GZ84
    • Q6GZ85
    • Q6GZ87
    • Q6GZ89

    Protein attributes for NR1I3 Gene

    Size:
    352 amino acids
    Molecular mass:
    39942 Da
    Quaternary structure:
    • Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR1I3 Gene

neXtProt entry for NR1I3 Gene

Proteomics data for NR1I3 Gene at MOPED

Post-translational modifications for NR1I3 Gene

  • Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NR1I3 Gene

Domains for NR1I3 Gene

Gene Families for NR1I3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14994

UniProtKB/Swiss-Prot:

NR1I3_HUMAN :
  • Q14994
Domain:
  • Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1I3: view

Function for NR1I3 Gene

Molecular function for NR1I3 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several isoforms
UniProtKB/Swiss-Prot Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element
UniProtKB/Swiss-Prot Induction:
By dexamethasone

Gene Ontology (GO) - Molecular Function for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11114890
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 11114890
GO:0003677 DNA binding TAS 9783588
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8020947
GO:0003707 steroid hormone receptor activity --
genes like me logo Genes that share ontologies with NR1I3: view
genes like me logo Genes that share phenotypes with NR1I3: view

Animal Models for NR1I3 Gene

MGI Knock Outs for NR1I3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NR1I3 Gene

Localization for NR1I3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1I3 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR1I3 Gene COMPARTMENTS Subcellular localization image for NR1I3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NR1I3: view

Pathways for NR1I3 Gene

genes like me logo Genes that share pathways with NR1I3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 8020947
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NR1I3: view

Compounds for NR1I3 Gene

(4) Tocris Compounds for NR1I3 Gene

Compound Action Cas Number
CITCO Selective CAR agonist [338404-52-7]
Clotrimazole Cytochrome P450 inhibitor; antifungal [23593-75-1]
S 07662 Inverse agonist of the constitutive androstane receptor (CAR) [883226-64-0]
TCPOBOP Constitutive androstane receptor agonist [76150-91-9]

(7) HMDB Compounds for NR1I3 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Ethanol
  • 1-Hydroxyethane
64-17-5
Isobutanol
  • 1-Hydroxymethylpropane
78-83-1

(2) Drugbank Compounds for NR1I3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(5BETA)-PREGNANE-3,20-DIONE
target
16,17-Androstene-3-Ol
7148-51-8 target

(4) IUPHAR Ligand for NR1I3 Gene

Ligand Type Action Affinity Pubmed IDs
CITCO Agonist Agonist 7.3
meclizine Antagonist Antagonist 7.16
pregnanedione Agonist Agonist 6.17
clotrimazole Channel blocker None

(73) Novoseek inferred chemical compound relationships for NR1I3 Gene

Compound -log(P) Hits PubMed IDs
androstane 99.2 194
citco 97.5 11
androstanol 91.6 9
tcpobop 87.4 18
androstenol 85 7
genes like me logo Genes that share compounds with NR1I3: view

Transcripts for NR1I3 Gene

Unigene Clusters for NR1I3 Gene

Nuclear receptor subfamily 1, group I, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NR1I3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR1I3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for NR1I3 Gene

GeneLoc Exon Structure for
NR1I3
ECgene alternative splicing isoforms for
NR1I3

Expression for NR1I3 Gene

mRNA expression in normal human tissues for NR1I3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR1I3 Gene

This gene is overexpressed in Liver (44.0).

Protein differential expression in normal tissues for NR1I3 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NR1I3 Gene

SOURCE GeneReport for Unigene cluster for NR1I3 Gene Hs.349642

mRNA Expression by UniProt/SwissProt for NR1I3 Gene

Q14994-NR1I3_HUMAN
Tissue specificity: Predominantly expressed in liver
genes like me logo Genes that share expressions with NR1I3: view

Expression partners for NR1I3 Gene

In Situ Assay Products

Orthologs for NR1I3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1I3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR1I3 35
  • 86.21 (n)
  • 83.62 (a)
NR1I3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR1I3 35
  • 86.14 (n)
  • 85.11 (a)
CAR 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr1i3 35
  • 80.75 (n)
  • 74.71 (a)
Nr1i3 16
Nr1i3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR1I3 35
  • 99.81 (n)
  • 100 (a)
NR1I3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr1i3 35
  • 81.57 (n)
  • 79.71 (a)
oppossum
(Monodelphis domestica)
Mammalia NR1I3 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR1I3 35
  • 62.5 (n)
  • 57.56 (a)
NR1I3 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR1I3 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EcR 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for NR1I3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NR1I3 Gene

ENSEMBL:
Gene Tree for NR1I3 (if available)
TreeFam:
Gene Tree for NR1I3 (if available)

Paralogs for NR1I3 Gene

genes like me logo Genes that share paralogs with NR1I3: view

Variants for NR1I3 Gene

Sequence variations from dbSNP and Humsavar for NR1I3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2307415 -- 161,236,568(-) GTGAC(A/G)TCATG utr-variant-5-prime, intron-variant
rs2307420 -- 161,232,766(-) ACTTC(A/G)GTAAA intron-variant
rs2307422 -- 161,236,056(-) TCCCA(G/T)GTCTT intron-variant
rs2307424 -- 161,232,815(-) CTGCC(C/T)GTCTT reference, synonymous-codon
rs2307425 -- 161,233,328(-) CTGTC(A/G)GCAGA synonymous-codon, reference, intron-variant

Relevant External Links for NR1I3 Gene

HapMap Linkage Disequilibrium report
NR1I3
Human Gene Mutation Database (HGMD)
NR1I3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR1I3 Gene

Disorders for NR1I3 Gene

(3) University of Copenhagen DISEASES for NR1I3 Gene

(39) Novoseek inferred disease relationships for NR1I3 Gene

Disease -log(P) Hits PubMed IDs
hyperparathyroidism secondary 73.2 14
nshpt 61.3 2
hyperparathyroidism 60.1 10
hypercalcemia 58.6 12
hyperparathyroidism primary 57.2 7

Relevant External Links for NR1I3

Genetic Association Database (GAD)
NR1I3
Human Genome Epidemiology (HuGE) Navigator
NR1I3
genes like me logo Genes that share disorders with NR1I3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for NR1I3 Gene

Publications for NR1I3 Gene

  1. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PMID: 15194709) Lamba J.K. … Schuetz E.G. (J. Pharmacol. Exp. Ther. 2004) 3 4 23
  2. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. (PMID: 15610735) Xu R.X. … Moore J.T. (Mol. Cell 2004) 3 4 23
  3. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PMID: 18056193) Tham L.S. … Goh B.C. (Clin. Cancer Res. 2007) 3 23 48
  4. Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PMID: 19858220) Mutoh S. … Negishi M. (J. Biol. Chem. 2009) 3 4 23
  5. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PMID: 8114692) Baes M. … Moore D.D. (Mol. Cell. Biol. 1994) 2 3 4

Products for NR1I3 Gene

Sources for NR1I3 Gene

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