Aliases for NR1I3 Gene
Aliases for NR1I3 Gene
- Nuclear Receptor Subfamily 1 Group I Member 3 2 3 5
- Constitutive Androstane Receptor 2 3 4
- Nuclear Receptor Subfamily 1, Group I, Member 3 2 3
- Constitutive Activator Of Retinoid Response 3 4
- Constitutive Active Response 3 4
- Orphan Nuclear Receptor MB67 3 4
- CAR 3 4
- Constitutive Androstane Nuclear Receptor Variant 2 3
External Ids for NR1I3 Gene
- HGNC: 7969
- Entrez Gene: 9970
- Ensembl: ENSG00000143257
- OMIM: 603881
- UniProtKB: Q14994
Previous GeneCards Identifiers for NR1I3 Gene
- GC01M158910
- GC01M156931
- GC01M157978
- GC01M158416
- GC01M158012
- GC01M159466
- GC01M132556
Summaries for NR1I3 Gene
-
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NR1I3 Gene
NR1I3 (Nuclear Receptor Subfamily 1 Group I Member 3) is a Protein Coding gene. Diseases associated with NR1I3 include Biliary Tract Disease and Hyperparathyroidism, Neonatal. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is NR4A2.
UniProtKB/Swiss-Prot for NR1I3 Gene
-
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
-
Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with retinoid X receptor family members, and are expressed in the intestine, thyroid and kidney.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1I3 Gene
Genomics for NR1I3 Gene
Regulatory Elements for NR1I3 Gene
Enhancers for NR1I3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around NR1I3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NR1I3 gene promoter:
Regulatory Element Products
Genomic Location for NR1I3 Gene
- Chromosome:
- 1
- Start:
- 161,229,666 bp from pter
- End:
- 161,238,598 bp from pter
- Size:
- 8,933 bases
- Orientation:
- Minus strand
Genomic View for NR1I3 Gene
Genes around NR1I3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.3 by Ensembl
- 1q23.3 by Entrez Gene
- 1q23.3 by HGNC
NR1I3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NR1I3 Gene
Proteins for NR1I3 Gene
-
Protein details for NR1I3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14994-NR1I3_HUMAN
- Recommended name:
- Nuclear receptor subfamily 1 group I member 3
- Protein Accession:
- Q14994
- E9PB75
- E9PC13
- E9PDU3
- E9PGH6
- E9PH10
- E9PHC8
- E9PHN4
- F1D8Q0
- F1D8Q1
- Q0VAC9
- Q4U0F0
- Q5VTW5
- Q5VTW6
- Q6GZ68
- Q6GZ76
- Q6GZ77
- Q6GZ78
- Q6GZ79
- Q6GZ82
- Q6GZ83
- Q6GZ84
- Q6GZ85
- Q6GZ87
- Q6GZ89
Protein attributes for NR1I3 Gene
- Size:
- 352 amino acids
- Molecular mass:
- 39942 Da
- Quaternary structure:
-
- Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).
Protein Expression for NR1I3 Gene
Post-translational modifications for NR1I3 Gene
- Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NR1I3 Gene
- ENSEMBL proteins:
-
- ENSP00000356959
- ENSP00000356960
- ENSP00000356961
- ENSP00000356962
- ENSP00000356963
- ENSP00000356965
- ENSP00000399361
- ENSP00000406493
- ENSP00000407446
- ENSP00000412672
- ENSP00000421374
- ENSP00000421588
- ENSP00000422982
- ENSP00000423007
- ENSP00000423089
- ENSP00000423666
- ENSP00000424345
- ENSP00000424834
- ENSP00000424934
- ENSP00000425417
- ENSP00000425607
- ENSP00000425900
- ENSP00000426016
- ENSP00000426292
- ENSP00000427034
- ENSP00000427175
- ENSP00000427600
- ENSP00000487337
- ENSP00000356958
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for NR1I3
- R&D Systems Antibodies for NR1I3 (CAR/NR1I3)
- Novus Biologicals Antibodies for NR1I3
- Invitrogen Antibodies for NR1I3
- antibodies-online Antibodies for NR1I3: See all 108
- GeneTex NR1I3 antibody for NR1I3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NR1I3
Protein Products
-
OriGene Purified Proteins for NR1I3
- NM_001077482
- NM_001077474
- NM_005122
- NM_001077469
- NM_001077471
- NM_001077482
- NM_005122
- NM_001077469
- NM_001077470
- NM_001077471
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- NM_001077469
- NM_001077470
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- Search Origene for MassSpec and Protein Over-expression Lysates for NR1I3
- Origene Custom Protein Services for NR1I3
- antibodies-online Proteins for NR1I3: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NR1I3
Assay Products
- antibodies-online Kits for NR1I3: See all 8
No data available for DME Specific Peptides for NR1I3 Gene
Domains & Families for NR1I3 Gene
Gene Families for NR1I3 Gene
- HGNC:
- IUPHAR :
Protein Domains for NR1I3 Gene
Suggested Antigen Peptide Sequences for NR1I3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14994UniProtKB/Swiss-Prot:
NR1I3_HUMAN :- Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
- Belongs to the nuclear hormone receptor family. NR1 subfamily.
- Domain:
-
- Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
- Contains 1 nuclear receptor DNA-binding domain.
- Family:
-
- Belongs to the nuclear hormone receptor family. NR1 subfamily.
Function for NR1I3 Gene
Molecular function for NR1I3 Gene
- GENATLAS Biochemistry:
- nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several isoforms
- UniProtKB/Swiss-Prot Function:
- Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
- UniProtKB/Swiss-Prot Induction:
- By dexamethasone.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | TAS | 8114692 |
| GO:0004882 | androgen receptor activity | TAS | 9783588 |
| GO:0004887 | thyroid hormone receptor activity | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for NR1I3 Gene
- MGI mutant phenotypes for NR1I3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NR1I3:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased shRNA abundance
Animal Models for NR1I3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for NR1I3
- Search ViGene Biosciences for NR1I3
CRISPR Products
-
OriGene CRISPR knockouts for NR1I3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
miRNA for NR1I3 Gene
- miRTarBase miRNAs that target NR1I3
miRNA Products
- Search ViGene Biosciences for NR1I3
Inhibitory RNA Products
Clone Products
- OriGene clones in human for NR1I3
- OriGene ORF clones in human,mouse,rat for NR1I3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR1I3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR1I3 Gene
Localization for NR1I3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NR1I3 Gene
- Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 3 |
| peroxisome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for NR1I3 Gene
More details on SuperPathways for NR1I3| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.49
|
|
| 2 | Nuclear Receptor transcription pathway | ||
| 3 | Phenytoin Pathway, Pharmacokinetics | ||
| 4 | Metabolism of xenobiotics by cytochrome P450 | ||
| 5 | Drug Induction of Bile Acid Pathway |
Pathways by source for NR1I3 Gene
4 BioSystems pathways for NR1I3 Gene
3 Reactome pathways for NR1I3 Gene
2 PharmGKB pathways for NR1I3 Gene
Interacting Proteins for NR1I3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IDA | 11114890 |
Drugs & Compounds for NR1I3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Clotrimazole | Approved | Pharma | Inhibition, Pore Blocker, inhibitor | Cytochrome P450 inhibitor; antifungal | 30 | |
| Meclizine | Approved | Pharma | Antagonist, modulator | 5 | ||
| Warfarin | Approved | Pharma | 435 | |||
| Androstenol | Experimental | Pharma | Target | 0 | ||
| (5BETA)-PREGNANE-3,20-DIONE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| TCPOBOP |
|
76150-91-9 |
|
|||
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| Isobutanol |
|
78-83-1 |
|
|||
| Isopropyl alcohol |
|
67-63-0 |
|
(5) Tocris Compounds for NR1I3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CITCO | Selective CAR agonist | 338404-52-7 |
| Clotrimazole | Cytochrome P450 inhibitor; antifungal | 23593-75-1 |
| PK 11195 | Antagonist at peripheral benzodiazepine receptors | 85532-75-8 |
| T 0901317 | Potent liver X receptor (LXR) agonist; also CAR inverse agonist | 293754-55-9 |
| TCPOBOP | Constitutive androstane receptor agonist | 76150-91-9 |
Drug Products
- Enzo Life Sciences drugs & compounds for NR1I3
Transcripts for NR1I3 Gene
mRNA/cDNA for NR1I3 Gene
- (19) REFSEQ mRNAs :
- (31) Additional mRNA sequences :
- (70) Selected AceView cDNA sequences:
- (35) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NR1I3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NR1I3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
miRNA Products
- Search ViGene Biosciences for NR1I3
Inhibitory RNA Products
Clone Products
- OriGene clones in human for NR1I3
- OriGene ORF clones in human,mouse,rat for NR1I3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NR1I3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | |||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - |
Expression for NR1I3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for NR1I3 Gene
This gene is overexpressed in Liver (x44.0).
This gene is overexpressed in Fetal gut (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR1I3 Gene
SOURCE GeneReport for Unigene cluster for NR1I3 Gene Hs.349642
mRNA Expression by UniProt/SwissProt for NR1I3 Gene
Q14994-NR1I3_HUMAN
Tissue specificity:
Predominantly expressed in liver.
Primer Products
-
OriGene qPCR primer pairs for NR1I3
-
OriGene qPCR primer pairs and template standards for NR1I3
Orthologs for NR1I3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | NR1I3 35 |
|
||
| NR1I3 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | NR1I3 35 |
|
||
| CAR 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Nr1i3 35 |
|
||
| Nr1i3 16 |
|
||||
| Nr1i3 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | NR1I3 35 |
|
||
| NR1I3 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Nr1i3 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NR1I3 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NR1I3 35 |
|
||
| NR1I3 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | NR1I3 36 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | EcR 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for NR1I3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NR1I3 Gene
Paralogs for NR1I3 Gene
(57) SIMAP similar genes for NR1I3 Gene using alignment to 22 proteins:
- THRB
- NR3C2
- HNF4alpha
- NR3C4
- AR
- VDR
- ESR2
- NR5A2
- RXRB
- ESRRG
- ERRgamma
- NR3C1
- RORA
- ESR1
- PPARG
- NR4A1
- NR1C3
- NR2A2
- NR3B3
- NR2A3
- NR2C2
- NR5A1
- ESRRB
- THRA
- NR4A2
- HNF4G
- NR1F2
- RORB
- NR1F1
- NR2C1
- RORC
- NR2A1
- NR1F3
- NR1H2
- NR2F6
- NR1A2
- NR1D2
- NR1H3
- DKFZp761C0417
- RXRA
- NR2B3
- NR1H4
- DKFZp686P04237
- NR1I2
- NR2F1
- NR1B2
- RARB
- NR1B1
- NR1I1
- NR2E1
- RARA
- BCOR-RARA
- NR1A1
- NR6A1
- NR1i2
- NR1i1
- DKFZp686D1580
Variants for NR1I3 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_018344 | - | ||||
| rs2307415 | -- | 161,236,568(-) | GTGAC(A/G)TCATG | intron-variant, utr-variant-5-prime | |
| rs2307420 | -- | 161,232,766(-) | ACTTC(A/G)GTAAA | intron-variant | |
| rs2307422 | -- | 161,236,056(-) | TCCCA(G/T)GTCTT | intron-variant | |
| rs2307424 | -- | 161,232,815(-) | CTGCC(C/T)GTCTT | reference, synonymous-codon |
Residual Variation Intolerance Score:
71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.11;
22.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NR1I3 Gene
- Human Gene Mutation Database (HGMD)
- NR1I3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR1I3 Gene
Disorders for NR1I3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| biliary tract disease |
|
|
| hyperparathyroidism, neonatal |
|
|
| intrahepatic cholestasis |
|
|
| neonatal jaundice |
|
|
| bilirubin metabolic disorder |
|
Search NR1I3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NR1I3
No data available for UniProtKB/Swiss-Prot and Genatlas for NR1I3 Gene
Publications for NR1I3 Gene
- A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PMID: 8114692) Baes M. … Moore D.D. (Mol. Cell. Biol. 1994) 2 3 4 67
- Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (PMID: 19682433) Yoshinari K. … Yamazoe Y. (Biochem. Pharmacol. 2010) 3 23
- Effect of oncostatin M on uridine diphosphate-5'-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor. (PMID: 20197307) Masuyama H. … Hiramatsu Y. (Mol. Endocrinol. 2010) 3 23
- Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers. (PMID: 20218903) Oliver P. … Carcas A. (Clin. Chem. Lab. Med. 2010) 3 23
- Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. (PMID: 19034627) Li L. … Wang H. (Pharm. Res. 2009) 3 23
Products for NR1I3 Gene
- R&D Systems Antibodies for NR1I3 (CAR/NR1I3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Luminex Assays
- Browse Peptides
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- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NR1I3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NR1I3
- NM_001077482
- NM_001077474
- NM_005122
- NM_001077469
- NM_001077471
- NM_001077482
- NM_005122
- NM_001077469
- NM_001077470
- NM_001077471
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- NM_001077469
- NM_001077470
- NM_001077472
- NM_001077473
- NM_001077475
- NM_001077476
- NM_001077477
- NM_001077478
- NM_001077479
- NM_001077481
- NM_001077482
- Search Origene for MassSpec and Protein Over-expression Lysates for NR1I3
- Origene Custom Protein Services for NR1I3
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for NR1I3
- Browse OriGene Inhibitory RNA Products For NR1I3
- OriGene qPCR primer pairs for NR1I3
- OriGene qPCR primer pairs and template standards for NR1I3
- OriGene CRISPR knockouts for NR1I3
- OriGene clones in human for NR1I3
- OriGene ORF clones in human,mouse,rat for NR1I3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for NR1I3
- GenScript Custom Assay Services for NR1I3
- GenScript Custom overexpressing Cell Line Services for NR1I3
- GenScript: Design CRISPR guide RNA sequences for NR1I3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NR1I3
- Novus Biologicals Antibodies for NR1I3
- Novus Biologicals proteins and lysates for NR1I3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for NR1I3: See all 108
- antibodies-online Kits for NR1I3: See all 8
- antibodies-online Proteins for NR1I3: See all 14
- Search antibodies-online for peptides
- GeneTex NR1I3 antibody for NR1I3
- Search GeneTex for Proteins for NR1I3
- Search ViGene Biosciences for NR1I3
- Search ViGene Biosciences for NR1I3
- Santa Cruz Biotechnology (SCBT) Antibodies for NR1I3
- Search Santa Cruz Biotechnology (SCBT) for NR1I3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NR1I3
Sources for NR1I3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon