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Aliases for NR1I3 Gene

Aliases for NR1I3 Gene

  • Nuclear Receptor Subfamily 1 Group I Member 3 2 3 5
  • Constitutive Androstane Receptor 2 3 4
  • Constitutive Activator Of Retinoid Response 3 4
  • Constitutive Active Response 3 4
  • Orphan Nuclear Receptor MB67 3 4
  • CAR 3 4
  • Constitutive Androstane Nuclear Receptor Variant 2 3
  • Constitutive Androstane Nuclear Receptor Variant 3 3
  • Constitutive Androstane Nuclear Receptor Variant 4 3
  • Constitutive Androstane Nuclear Receptor Variant 5 3
  • Nuclear Receptor Subfamily 1, Group I, Member 3 2
  • Orphan Nuclear Hormone Receptor 3
  • Constitutive Active Receptor 3
  • Car1 3
  • MB67 3

External Ids for NR1I3 Gene

Previous GeneCards Identifiers for NR1I3 Gene

  • GC01M158910
  • GC01M156931
  • GC01M157978
  • GC01M158416
  • GC01M158012
  • GC01M159466
  • GC01M132556

Summaries for NR1I3 Gene

Entrez Gene Summary for NR1I3 Gene

  • This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR1I3 Gene

NR1I3 (Nuclear Receptor Subfamily 1 Group I Member 3) is a Protein Coding gene. Diseases associated with NR1I3 include Biliary Tract Disease and Hyperparathyroidism, Neonatal. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Nuclear Receptors in Lipid Metabolism and Toxicity. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for NR1I3 Gene

  • Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.

Tocris Summary for NR1I3 Gene

  • Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with retinoid X receptor family members, and are expressed in the intestine, thyroid and kidney.

Gene Wiki entry for NR1I3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1I3 Gene

Genomics for NR1I3 Gene

Regulatory Elements for NR1I3 Gene

Enhancers for NR1I3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161388 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -151.3 -151338 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 SDHC ATF6 CFAP126 NR1I3 APOA2 TOMM40L MPZ FCRLA FCER1G FCGR2A
GH01G161206 1.7 FANTOM5 ENCODE dbSUPER 11.8 +31.4 31356 2.1 HDGF FOXA2 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 B4GALT3 PPOX NR1I3 SDHC MPZ LOC105371471 NDUFS2 TOMM40L ADAMTS4 APOA2
GH01G161381 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -144.2 -144226 2.1 CTCF ZNF654 CEBPB MAFG REST ATF2 RAD21 RFX5 ZNF316 ZBTB48 SDHC NR1I3 APOA2 TOMM40L ADAMTS4 NDUFS2 MPZ RRM2P2 ENSG00000283696
GH01G161304 1 ENCODE 11.4 -67.9 -67855 3.0 HDGF PKNOX1 ATF1 CREB3L1 YY1 FOS KLF13 SP5 JUNB SMARCB1 FCER1G NDUFS2 NR1I3 APOA2 TOMM40L PCP4L1 SDHC FCGR2C MPZ LOC105371472
GH01G161209 0.9 ENCODE 12.4 +28.8 28769 0.8 ELF3 HDGF HDAC1 RB1 ARID4B ZNF2 ZNF48 ZBTB40 RAD21 RARA NR1I3 CFAP126 SDHC NDUFS2 FCER1G ADAMTS4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NR1I3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NR1I3 Gene

Chromosome:
1
Start:
161,229,666 bp from pter
End:
161,238,598 bp from pter
Size:
8,933 bases
Orientation:
Minus strand

Genomic View for NR1I3 Gene

Genes around NR1I3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR1I3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR1I3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1I3 Gene

Proteins for NR1I3 Gene

  • Protein details for NR1I3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14994-NR1I3_HUMAN
    Recommended name:
    Nuclear receptor subfamily 1 group I member 3
    Protein Accession:
    Q14994
    Secondary Accessions:
    • E9PB75
    • E9PC13
    • E9PDU3
    • E9PGH6
    • E9PH10
    • E9PHC8
    • E9PHN4
    • F1D8Q0
    • F1D8Q1
    • Q0VAC9
    • Q4U0F0
    • Q5VTW5
    • Q5VTW6
    • Q6GZ68
    • Q6GZ76
    • Q6GZ77
    • Q6GZ78
    • Q6GZ79
    • Q6GZ82
    • Q6GZ83
    • Q6GZ84
    • Q6GZ85
    • Q6GZ87
    • Q6GZ89

    Protein attributes for NR1I3 Gene

    Size:
    352 amino acids
    Molecular mass:
    39942 Da
    Quaternary structure:
    • Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR1I3 Gene

neXtProt entry for NR1I3 Gene

Post-translational modifications for NR1I3 Gene

  • Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR1I3 Gene

Domains & Families for NR1I3 Gene

Gene Families for NR1I3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14994

UniProtKB/Swiss-Prot:

NR1I3_HUMAN :
  • Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1I3: view

Function for NR1I3 Gene

Molecular function for NR1I3 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 1,group I,member 3,putatively heterodimerizing with RXR(s),expressed as several isoforms
UniProtKB/Swiss-Prot Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Gene Ontology (GO) - Molecular Function for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11114890
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 11114890
GO:0003677 DNA binding IEA,TAS 9783588
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 8020947
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR1I3: view
genes like me logo Genes that share phenotypes with NR1I3: view

Animal Models for NR1I3 Gene

MGI Knock Outs for NR1I3:

miRNA for NR1I3 Gene

miRTarBase miRNAs that target NR1I3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR1I3 Gene

Localization for NR1I3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1I3 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR1I3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
peroxisome 3
cytosol 3

Gene Ontology (GO) - Cellular Components for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NR1I3: view

Pathways & Interactions for NR1I3 Gene

genes like me logo Genes that share pathways with NR1I3: view

SIGNOR curated interactions for NR1I3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR1I3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 8020947
GO:0030521 androgen receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NR1I3: view

Drugs & Compounds for NR1I3 Gene

(58) Drugs for NR1I3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker, inhibitor Cytochrome P450 inhibitor; antifungal 38
Meclizine Approved Pharma Antagonist, modulator 5
Dehydroepiandrosterone Approved Nutra Target, activator 95
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 409

(35) Additional Compounds for NR1I3 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Androstenol
  • (3a,5a)-Androst-16-en-3-ol
  • (3alpha,5alpha)-Androst-16-en-3-ol
  • 16,17-Androstene-3-ol
  • 3a-Hydroxy-5a-androst-16-ene
  • 3a-Hydroxyandrost-16-ene
1153-51-1
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1

(5) Tocris Compounds for NR1I3 Gene

Compound Action Cas Number
CINPA 1 Potent CAR antagonist 102636-74-8
CITCO Selective CAR agonist 338404-52-7
Clotrimazole Cytochrome P450 inhibitor; antifungal 23593-75-1
S 07662 Inverse agonist of the constitutive androstane receptor (CAR) 883226-64-0
TCPOBOP Constitutive androstane receptor agonist 76150-91-9

(4) ApexBio Compounds for NR1I3 Gene

Compound Action Cas Number
Fexaramine 574013-66-4
GW3965 HLXRα/hLXRβ agonist,potent and selective 405911-09-3
LXR-623 Liver X-receptor agonist 875787-07-8
SR-9243 inverse agonist of LXR 1613028-81-1
genes like me logo Genes that share compounds with NR1I3: view

Drug Products

Transcripts for NR1I3 Gene

Unigene Clusters for NR1I3 Gene

Nuclear receptor subfamily 1, group I, member 3:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR1I3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for NR1I3 Gene

GeneLoc Exon Structure for
NR1I3
ECgene alternative splicing isoforms for
NR1I3

Expression for NR1I3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR1I3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR1I3 Gene

This gene is overexpressed in Liver (x44.0).

Protein differential expression in normal tissues from HIPED for NR1I3 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR1I3 Gene



Protein tissue co-expression partners for NR1I3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR1I3 Gene:

NR1I3

SOURCE GeneReport for Unigene cluster for NR1I3 Gene:

Hs.349642

mRNA Expression by UniProt/SwissProt for NR1I3 Gene:

Q14994-NR1I3_HUMAN
Tissue specificity: Predominantly expressed in liver.

Evidence on tissue expression from TISSUES for NR1I3 Gene

  • Liver(4.8)
  • Intestine(4.4)
  • Eye(4)
genes like me logo Genes that share expression patterns with NR1I3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NR1I3 Gene

Orthologs for NR1I3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1I3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR1I3 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia NR1I3 34 35
  • 86.21 (n)
dog
(Canis familiaris)
Mammalia NR1I3 34
  • 86.14 (n)
CAR 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr1i3 34
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Nr1i3 34 16 35
  • 80.75 (n)
oppossum
(Monodelphis domestica)
Mammalia NR1I3 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR1I3 34 35
  • 62.5 (n)
lizard
(Anolis carolinensis)
Reptilia NR1I3 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EcR 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
OneToMany
Species where no ortholog for NR1I3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NR1I3 Gene

ENSEMBL:
Gene Tree for NR1I3 (if available)
TreeFam:
Gene Tree for NR1I3 (if available)

Paralogs for NR1I3 Gene

Paralogs for NR1I3 Gene

genes like me logo Genes that share paralogs with NR1I3: view

Variants for NR1I3 Gene

Sequence variations from dbSNP and Humsavar for NR1I3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs148277311 Likely benign 161,235,903(+) AGTGG(C/T)GCCTC reference, missense
rs35205211 Likely benign 161,233,319(-) GAAGC(C/G)CTGGC reference, synonymous-codon
rs143067018 Uncertain significance 161,232,814(+) GAAGA(C/T)GGGCA reference, missense
rs150124500 Uncertain significance 161,229,905(+) AGGCC(G/T)AGCAA intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs398122411 Uncertain significance 161,231,200(-) GCTCT(C/T)TCACT intron-variant, reference, missense

Variation tolerance for NR1I3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR1I3 Gene

Human Gene Mutation Database (HGMD)
NR1I3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR1I3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR1I3 Gene

Disorders for NR1I3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NR1I3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
biliary tract disease
  • biliary tract diseases
hyperparathyroidism, neonatal
  • hyperparathyroidism, neonatal severe
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
neonatal jaundice
  • neonatal hyperbilirubinemia
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards
Search NR1I3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NR1I3

Genetic Association Database (GAD)
NR1I3
Human Genome Epidemiology (HuGE) Navigator
NR1I3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR1I3
genes like me logo Genes that share disorders with NR1I3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR1I3 Gene

Publications for NR1I3 Gene

  1. Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). (PMID: 19858220) Mutoh S. … Negishi M. (J. Biol. Chem. 2009) 3 4 22 64
  2. Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics. (PMID: 18056193) Tham L.S. … Goh B.C. (Clin. Cancer Res. 2007) 3 22 46 64
  3. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (PMID: 15194709) Lamba J.K. … Schuetz E.G. (J. Pharmacol. Exp. Ther. 2004) 3 4 22 64
  4. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. (PMID: 8114692) Baes M. … Moore D.D. (Mol. Cell. Biol. 1994) 2 3 4 64
  5. Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. (PMID: 19682433) Yoshinari K. … Yamazoe Y. (Biochem. Pharmacol. 2010) 3 22 64

Products for NR1I3 Gene

Sources for NR1I3 Gene

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