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Aliases &
Descriptions
for NR1H4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
User Feedback | | Aliases & Descriptions |
|---|
| nuclear receptor subfamily 1, group H, member 41 2 | | Farnesoid X-activated receptor2 3 | | RIP141 2 3 | | BAR2 3 | | HRR11 2 3 | | RXR-interacting protein 142 3 | | FXR1 2 3 | | MGC1634452 | | HRR-11 2 | | bile acid receptor2 | | Retinoid X receptor-interacting protein 142 3 | | farnesoid X receptor2 | | Farnesol receptor HRR-12 3 | | Nuclear receptor subfamily 1 group H member 43 |
Search outside databases for aliases for NR1H4 genePrevious GC identifers: GC12P100078 GC12P099370 |
Summaries
for NR1H4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
User Feedback | UniProtKB/Swiss-Prot: NR1H4_HUMAN, Q96RI1Function: Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses thetranscription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression,via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcriptionof bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus
 summary
for NR1H4:Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear
receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There are two
closely related isoforms of each of these enzymes; LXRalpha and LXRbeta, and FXRalpha and FXRbeta
(pseudogene in man). LXRalpha and FXRalpha expression is restricted to the liver, small intestine, kidney
and adrenal gland, whilst LXRbeta and FXRbeta are ubiquitously expressed. Despite acting on some of the same
target genes, including cholesterol 7alpha-hydroxylase (CYP7A1) and SREBP-1c, LXRs and FXRs have different
physiological roles. LXRs are involved in cholesterol homeostasis, inhibition of proinflammatory gene
expression in atherosclerosis and activation of innate immunity, whilst FXRs have a vital function in bile
acid homeostasis.
Gene Wiki entry for NR1H4 (Farnesoid X receptor) |
Genomic Views
for NR1H4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl (release 56),
Regulatory elements and Epigenetics data according to
SABiosciences)
About This Section
User Feedback | Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR1H4 gene upstream (promoter) region  :
NRSF form 1 NRSF form 2 HNF-4alpha2 COUP-TF1 SREBP-1a SREBP-1c SREBP-1b FOXO1a PPAR-gamma2 PPAR-gamma1
Epigenetics:
Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for NR1H4 
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.1NR1H4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P100850: view genomic region
(about GC identifiers)
Start:
|
100,867,679 bp from pter |
End:
|
100,957,643 bp from pter |
Size:
|
89,965 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
| Proteins
for NR1H4 gene
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene,
Novus Biologicals, and/or
Sino Biological,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abnova,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
User Feedback | UniProtKB/Swiss-Prot: NR1H4_HUMAN, Q96RI1 (See
protein sequence)Recommended Name: Bile acid receptor Size: 486 amino acids; 55914 Da
Subunit: Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1
Subcellular location: Nucleus (Probable)
PDB structures from  and Proteopedia  :1OSH (3D)
1OSK (3D)
3BEJ (3D)
3DCT (3D)
3DCU (3D)
3FLI (3D)
3FXV (3D)
3GD2 (3D)
3HC5 (3D)
3HC6 (3D)
Secondary accessions: A1L4K5 B7Z412 Q8NFP5 Q8NFP6 Q92943Alternative splicing: 4 isoforms: Q96RI1-3 Q96RI1-4 Q96RI1-1 Q96RI1-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005114.1
ENSEMBL proteins: ENSP00000376712 ENSP00000315442 ENSP00000188403
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
NR1H4 for ontologies About GeneDecksing
Antibodies for NR1H4:
Assays for NR1H4: | Protein
Domains/
Families
for NR1H4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
User Feedback |
NR1H4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6
):Graphical View of Domain Structure for InterPro Entry Q96RI1ProtoNet protein and cluster: Q96RI1 2 Blocks protein families: IPB000324 Vitamin D receptor signature IPB001723 Steroid hormone receptor signature
UniProtKB/Swiss-Prot: NR1H4_HUMAN, Q96RI1Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain | Gene Function
for NR1H4 gene
(According to MGI May 08 2010, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Millipore,
Abnova,
siRNAs from
Applied Biosystems,
Sigma-Aldrich, Clones from
Millipore,
Sigma-Aldrich,
OriGene,
Sino Biological,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene.)
About This Section
User Feedback | UniProtKB/Swiss-Prot: NR1H4_HUMAN, Q96RI1Function: Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses thetranscription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression,via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcriptionof bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus 5/14 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 14
): About this table
NR1H4 for ontologies About GeneDecksing
Animal Models: 5 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Nr1h4):
NR1H4 for phenotypes About GeneDecksing
| Pathways & Interactions
for NR1H4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
Applied Biosystems GeneAssist,
KEGG
and/or UniProtKB,
(map by GeneGo),
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene).
About This Section
User Feedback |
NR1H4 for pathways About GeneDecksing
1  Millipore Pathway for NR1H4
4  Sigma-Aldrich "Your Favorite Gene" Pathways for NR1H4 (Your Favorite Gene powered by Ingenuity)
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR1H4
5/35 Interacting proteins for NR1H4 (ENSP000001884033 Q96RI11) via UniProtKB, MINT, and/or STRING (see all 35
) About this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006109 | regulation of carbohydrate metabolic process |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007165 | signal transduction |
TAS | 10334993 | | GO:0008206 | bile acid metabolic process |
IEA | -- |
About this table
NR1H4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR1H4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
User Feedback |
NR1H4 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for NR1H4 |
Compounds for NR1H4 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| GW 4064 | Selective farnesoid X receptor (FXR) agonist | [278779-30-9] | | Fexaramine | Potent, selective farnesoid X receptor (FXR) agonist | [574013-66-4] |
About this table
10/173  Novoseek chemical compound relationships for NR1H4 gene (see all 173
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guggulsterone |
100.00 |
47 |
12525500 (7), 17135343 (5), 12705905 (4), 11988537 (3) (see all 27) |
| gw 4064 |
100.00 |
66 |
15817812 (3), 12052824 (3), 19228886 (2), 18436567 (2) (see all 52) |
| cholic acid |
100.00 |
86 |
16002565 (6), 16357057 (5), 14684751 (5), 12004058 (5) (see all 49) |
| chenodeoxycholic acid |
100.00 |
93 |
16946559 (6), 19913492 (4), 18510855 (3), 13130122 (3) (see all 66) |
| androstane |
67.44 |
33 |
19300246 (2), 12923173 (2), 20048746 (1), 19932133 (1) (see all 31) |
| cholesterol |
64.36 |
197 |
12421815 (7), 12897188 (5), 19136377 (4), 15962294 (4) (see all 100) |
| 6-ethylchenodeoxycholic acid |
44.62 |
15 |
15644430 (3), 12166927 (2), 19864602 (1), 19783811 (1) (see all 12) |
| lithocholic acid |
18.45 |
14 |
12052824 (5), 16946559 (2), 16178789 (2), 19646460 (1) (see all 8) |
| androsterone |
15.99 |
12 |
16675527 (7), 19620049 (2), 17988216 (1), 17289849 (1) (see all 5) |
| deoxycholic acid |
13.20 |
12 |
12401785 (4), 15591588 (2), 19931294 (1), 18510604 (1) (see all 8) |
About this table
|
Transcripts
for NR1H4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Primers from
OriGene and/or
SABiosciences,
Expression Assays from Applied Biosystems)
About This Section
User Feedback | Assays:  Applied Biosystems TaqMan® Gene Expression Assays: NM_005123
| Clones: |  | Origene GFP tagged cDNA clones in CMV expression vector: NR1H4
Origene Myc/DDK tagged cDNA clones in CMV expression vector: NR1H4
Origene untagged cDNA clones in CMV expression vector: NR1H4
|
| Primers: | | Origene genome-wide validated SYBR primer pairs: NR1H4
| | | SABiosciences RT2 qPCR Primer Assay for NR1H4: PPH05878A |
REFSEQ mRNAs for NR1H4 gene: NM_005123.2 Additional cDNA sequence: AB307699.1 AF384555.1 AF478445.1 AF478446.1 AK296612.1 AK296647.1 AK312959.1 BC035654.1 BC071778.1 BC130573.1 BC144183.1 BC144184.1 BC144187.1 BX571749.1 U68233.1 7 DOTS entries: DT.213616 DT.100021403 DT.100746912 DT.444293 DT.40229020 DT.402350 DT.91756518 24/60 AceView cDNA sequences (see all 60
): AF478446 AI075131 AU104249 AA912967 AF478445 AI051958 BC071778 BX102734 BX571749 AI628645 BC035654 AF384555 AI245366 CB162215 BM545805 R92996 AA682292 T89438 AU099106 AI809578 NM_005123 AA862482 U68233 H79617
 highest scoring ESTs for NR1H4:U68233 AA682292 AA902549 AF384555 AF478445 AF478446 AI023303 AI075131 AI190683 AI244191 Unigene Cluster for NR1H4: Nuclear receptor subfamily 1, group H, member 4 Hs.282735 [show with all ESTs]Unigene Representative Sequence: BC035654
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NR1H4 (see all 7
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NR1H4
3 Ensembl transcripts including schematic representations: ENST00000392986
ENST00000321046
ENST00000188403
|
Expression
for NR1H4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems,
Primers from
OriGene and/or
SABiosciences
)
About This Section
User Feedback | NR1H4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NR1H4
1 / 2 / 3 4 probe-sets matching NR1H4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38519_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
U68233 |
1.00 |
1.00 |
1.00 |
1 |
| 206340_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_005123 |
0.60 |
1.00 |
0.82 |
1 |
| 1554375_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206340_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NR1H4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.282735
Expression variation in blood from EXPOLDB for NR1H4 | Primers: | | Origene genome-wide validated SYBR primer pairs: NR1H4 
| | | SABiosciences RT2 qPCR Primer Assay for NR1H4: PPH05878A |
|
Orthologs
for NR1H4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
User Feedback |
Orthologs for NR1H4 gene from 5/10 species (see all 10
)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
NR1H41 |
-- |
nuclear receptor subfamily 1, group H, member 4 |
90.6(n)
94.02(a) |
612928 XM_847866.1 XP_852959.1 |
chimpanzee
(Pan troglodytes) |
NR1H41 |
-- |
nuclear receptor subfamily 1, group H, member 4 |
99.58(n)
99.79(a) |
452162 XM_001153645.1 XP_001153645.1 |
cow
(Bos taurus) |
NR1H41 |
-- |
nuclear receptor subfamily 1, group H, member 4 |
92.15(n)
94.84(a) |
540528 NM_001034708.1 NP_001029880.1 |
rat
(Rattus norvegicus) |
Nr1h41 |
-- |
nuclear receptor subfamily 1, group H, member 4 |
85.4(n)
92.52(a) |
60351 NM_021745.1 NP_068513.1 |
mouse
(Mus musculus) |
Nr1h41, 5 |
10 (50.00 cM)5
|
nuclear receptor subfamily 1, group H, member 41, 5 |
86.55(n)1
94.17(a)1 |
201861 NM_009108.11 NP_033134.11
AI9573605 AK0025135 (see all 10) |
About this table Species with no ortholog for NR1H4
ENSEMBL Gene Tree for NR1H4 | Paralogs
for NR1H4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
User Feedback | Paralogs for NR1H4 gene
- VDR2 PPARD2 NR1I22 RARG2 PPARA2 THRB2 RARA2 RARB2
- NR1D22 RORA2 RORB2 RORC2 NR1D12 NR1I32 PPARG2 NR1H22
- THRA2 NR1H32
NR1H4 for paralogs About GeneDecksing
|
Genomic Variants
for NR1H4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants,
Genotyping Reagents from
Applied Biosystems)
About This Section
User Feedback |
HapMap Linkage Disequilibrium images for NR1H4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NR1H4
1 CNV: 38276 |
Disorders & Mutations
for NR1H4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
User Feedback |
NR1H4 for disorders About GeneDecksing
OMIM: 603826
10/107 Novoseek disease relationships for NR1H4 gene (see all 107
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| familial intrahepatic cholestasis |
53.94 |
26 |
18668687 (8), 14988830 (7), 19381753 (5), 19809379 (3) (see all 6) |
| cholestasis |
28.88 |
33 |
16844773 (4), 18327154 (3), 15644430 (3), 19300246 (2) (see all 20) |
| cholesterol gallstones |
16.71 |
13 |
15962294 (3), 15558057 (3), 15882126 (2), 17931734 (1) (see all 8) |
| fibrosis liver |
6.26 |
12 |
19910507 (5), 15980055 (3), 15521018 (3), 15860571 (1) |
| cholestasis intrahepatic |
5.82 |
6 |
18510855 (2), 19490418 (1), 17681172 (1), 14623915 (1) (see all 5) |
| disorder; metabolic |
4.50 |
10 |
19883617 (4), 18023284 (2), 19187229 (1), 18825165 (1) (see all 6) |
| cerebrotendinous xanthomatosis |
4.47 |
4 |
15576845 (4) |
| barrett esophagus |
4.26 |
10 |
18510604 (5), 17054793 (5) |
| non-alcoholic steatohepatitis |
4.04 |
6 |
19195631 (3), 19501927 (2), 17588816 (1) |
| leydig cell tumor |
3.55 |
4 |
20026603 (4) |
About this table
Human Gene Mutation Database: NR1H4
Human Genome Epidemiology Navigator: NR1H4 (11 documents)
|
Medical News
for NR1H4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
User Feedback | -- |
Publications
for NR1H4 gene (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
User Feedback | 100/385 PubMed articles for NR1H4 gene (see all 385
):- Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. (PubMed id 15471871)1, 3, 4 Ananthanarayanan M....Walsh M.J. (2004)
- Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. (PubMed id 12815072)1, 3, 4 Holt J.A....Jones S.A. (2003)
- Identification of a nuclear receptor for bile acids. (PubMed id 10334992)1, 3, 4 Makishima M.... Shan B. (1999)
- Bile acids: natural ligands for an orphan nuclear receptor. (PubMed id 10334993)1, 3, 4 Parks D.J....Lehmann J.M. (1999)
- BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. (PubMed id 12917342)3, 4 Hsiao P.W....Archer T.K. (2003)
- Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. (PubMed id 12062799)3, 4 Huber R.M.... Burn T.C. (2002)
- Activation of the orphan receptor RIP14 by retinoids. (PubMed id 9223286)2, 3 Zavacki A.M....Moore D.D. (1997)
- Identification of a nuclear receptor that is activated by farnesol metabolites. (PubMed id 7774010)2, 3 Forman B.M....Weinberger C. (1995)
- Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064. (PubMed id 19228886)1, 3 MartA-nez-FernA!ndez P....Alvarez L. (2009)
- The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. (PubMed id 14684751)1, 3 Lew J.L....Cui J. (2004)
- FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PubMed id 16251721)1, 3 Lee H.... Edwards P.A. (2006)
- Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter. (PubMed id 18769028)1, 3 Shen H....Shen X. (2008)
- The bile acid receptor FXR is a modulator of intestin al innate immunity. (PubMed id 19864602)1, 3 Vavassori P....Fiorucci S. (year=2009;month=Nov;day=15)
- Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. (PubMed id 15817812)1, 3 Qin P....Harnish D.C. (2005)
- FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. (PubMed id 12806625)1, 3 Barbier O....Staels B. (2003)
- Reciprocal regulation of the bile acid-activated rece ptor FXR and the interferon-gamma-STAT-1 pathway in macrophages. (PubMed id 19393742)1, 3 Renga B....Fiorucci S. (year=2009;month=Jun;day=)
- The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis. (PubMed id 19195631)1, 3 Cariou B. (2008)
- VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. (PubMed id 16037943)1, 3 Chignard N....Housset C. (2005)
- Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. (PubMed id 16197915)1, 3 Bungard C.I. and McGivan J.D. (2005)
- Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. (PubMed id 17054793)1, 3 De Gottardi A....Hadengue A. (2006)
- The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PubMed id 16269519)1, 3 Landrier J.F....Kullak-Ublick G.A. (2006)
- The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner. (PubMed id 15202934)1, 3 Kanaya E....Jingami H. (2004)
- ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. (PubMed id 19027009)1, 3 Cai S.Y....Boyer J.L. (2009)
- FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9. (PubMed id 19150878)1, 3 Das A....Shah V.H. (2009)
- Upregulation of decorin by FXR in vascular smooth muscle cells. (PubMed id 18514055)1, 3 He F....Li S. (2008)
- Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. (PubMed id 17931734)1, 3 Kovacs P....Wittenburg H. (2008)
- The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. (PubMed id 18842595)1, 3 Fang S....Kemper J.K. (2008)
- Analysis of bile acid-induced regulation of FXR target genes in human liver slices. (PubMed id 17241392)1, 3 Jung D....Groothuis G.M. (2007)
- Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. (PubMed id 17681172)1, 3 Van Mil S.W....Williamson C. (2007)
- Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PubMed id 16423920)1, 3 Boyer J.L....Ballatori N. (2006)
- LXRS and FXR: the yin and yang of cholesterol and fat metabolism. (PubMed id 16460270)1, 3 Kalaany N.Y. and Mangelsdorf D.J. (2006)
- The region of CQQQKPQRRP of PGC-1alpha interacts with the DNA-binding complex of FXR/RXRalpha. (PubMed id 16494845)1, 3 Kanaya E. and Jingami H. (2006)
- Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling. (PubMed id 15604525)1, 3 Anisfeld A.M....Edwards P.A. (2005)
- Regulation of complement C3 expression by the bile acid receptor FXR. (PubMed id 15590640)1, 3 Li J....Westin S.K. (2005)
- Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. (PubMed id 15454728)1, 3 Gnerre C....Meyer U.A. (2004)
- Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. (PubMed id 14729567)1, 3 Zhang Y....Edwards P.A. (2004)
- Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha. (PubMed id 18768987)3 Ramiere C....Andre P. (2008)
- The role of FXR in disorders of bile acid homeostasis. (PubMed id 18927204)3 Eloranta J.J. and Kullak-Ublick G.A. (2008)
- Functional analysis on the 5'-flanking region of human FXR gene in HepG2 cells. (PubMed id 17507182)3 Lou G....Zhou D. (2007)
- The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone. (PubMed id 16675527)1 Wang S....Evans M.J. (2006)
- Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. (PubMed id 15307955)1 Zhao A....Cui J. (2004)
- The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. (PubMed id 15911693)1 Rizzo G....Fiorucci S. (2005)
- Transient impairment of the adaptive response to fast ing in FXR-deficient mice. (PubMed id 16023103)1 Cariou B....Staels B. (year=2005;month=Aug;day=1)
- FXR an emerging therapeutic target for the treatment of atherosclerosis. (PubMed id 20041971)1 Mencarelli A. and Fiorucci S. (year=2010;month=Jan;day=)
- A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. (PubMed id 19136377)1 Evans M.J....Harnish D.C. (2009)
- Role of FXR in regulating bile acid homeostasis and relevance for human diseases. (PubMed id 16178789)1 Rizzo G....Fiorucci S. (2005)
- FXR as a novel therapeutic target for vascular disease. (PubMed id 15605109)1 Bishop-Bailey D. (2004)
- Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation. (PubMed id 13130122)1 Fujino T....Nishimaki-Mogami T. (2004)
- Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. (PubMed id 12519787)1 Kassam A....Mukherjee R. (2003)
- FXR, a bile acid receptor and biological sensor. (PubMed id 11150726)1 Tu H....Shan B. (2000)
- The nuclear receptor SHP mediates inhibition of hepat ic stellate cells by FXR and protects against liver fibrosis. (PubMed id 15521018)1 Fiorucci S....Morelli A. (year=2004;month=Nov;day=)
- Is the FXR the fix for cholesterol gallstone disease? (PubMed id 15962294)1 Juran B.D. and Lazaridis K.N. (2005)
- Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. (PubMed id 15558057)1 Moschetta A....Mangelsdorf D.J. (2004)
- [On the bile acid receptor FXR] (PubMed id 14992012)1 Li S....Guan Y.F. (2003)
- A natural product that lowers cholesterol as an antag onist ligand for FXR. (PubMed id 11988537)1 Urizar N.L....Moore D.D. (year=2002;month=May;day=31)
- FXR signaling in metabolic disease. (PubMed id 18023284)1 Zhang Y. and Edwards P.A. (2008)
- Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands. (PubMed id 16617018)1 Kainuma M....Hashimoto Y. (2006)
- Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4. (PubMed id 16284190)1 Gutierrez A....Davis R.A. (2006)
- FXR, a therapeutic target for bile acid and lipid disorders. (PubMed id 16101408)1 Westin S....Martin R. (2005)
- Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha. (PubMed id 15329387)1 Savkur R.S....Burris T.P. (2005)
- A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. (PubMed id 12718892)1 Downes M....Evans R.M. (2003)
- Identification of gene-selective modulators of the bile acid receptor FXR. (PubMed id 12496277)1 Dussault I....Forman B.M. (2003)
- BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. (PubMed id 11792716)1 Edwards P.A....Anisfeld A.M. (2002)
- The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases. (PubMed id 11254888)1 Niesor E.J....Bentzen C.L. (2001)
- Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. (PubMed id 10360171)1 Wang H....Forman B.M. (1999)
- Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio. (PubMed id 19273385)1 Modica S....Moschetta A. (2009)
- Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists. (PubMed id 19118524)1 Zhang S....Harnish D.C. (2009)
- Combined functional variants of hepatobiliary transpo rters and FXR aggravate intrahepatic cholestasis of pregnancy. (PubMed id 19490418)1 Zimmer V....Lammert F. (2009)
- Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. (PubMed id 19429418)1 Khan A.A....Groothuis G.M. (2009)
- Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist. (PubMed id 19328688)1 Feng S....Chen L. (2009)
- Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064. (PubMed id 19410460)1 Bass J.Y....Wisely G.B. (2009)
- FXR, a target for different diseases. (PubMed id 18283647)1 Wang Y.D....Huang W. (2008)
- Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR. (PubMed id 18096266)1 Scholtes C....Andre P. (2008)
- FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element. (PubMed id 18562803)1 Park S.S....Kim E. (2008)
- [Functional analysis of nuclear receptor FXR controlling metabolism of cholesterol] (PubMed id 18311053)1 Ohno M. (2008)
- Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential. (PubMed id 18537536)1 Zimber A. and Gespach C. (2008)
- FXR: a metabolic regulator and cell protector. (PubMed id 18825165)1 Wang Y.D....Huang W. (2008)
- Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. (PubMed id 18391212)1 Soisson S.M....Becker J.W. (2008)
- FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. (PubMed id 17823457)1 Jung D....Moschetta A. (2007)
- Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist. (PubMed id 17292610)1 Kainuma M....Miyachi H. (2007)
- FXR: a promising target for the metabolic syndrome? (PubMed id 17412431)1 Cariou B. and Staels B. (2007)
- [Farnesoid X receptor (FXR): a novel regulative factor involved in metabolism] (PubMed id 17882978)1 Zhang X.Y. and Guan Y.F. (2007)
- Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity. (PubMed id 17988093)1 Nam S.J....Kang H. (2007)
- A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. (PubMed id 16269825)1 Shih D.M....Lusis A.J. (2006)
- FXR, a multipurpose nuclear receptor. (PubMed id 16908160)1 Lee F.Y....Zhang Y. (2006)
- FXR: a target for cholestatic syndromes? (PubMed id 16706681)1 Cai S.Y. and Boyer J.L. (2006)
- Nuclear bile acid receptor FXR as pharmacological target: are we there yet? (PubMed id 16904670)1 Modica S. and Moschetta A. (2006)
- Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. (PubMed id 15581595)1 Handschin C. and Meyer U.A. (2005)
- T0901317 is a dual LXR/FXR agonist. (PubMed id 15464433)1 Houck K.A....Burris T.P. (2004)
- The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. (PubMed id 15309887)1 De Gottardi A....Dufour J.F. (2004)
- Ligand-binding domain of farnesoid X receptor (FXR) had the highest sensitivity and activity among FXR variants in a fluorescence-based assay. (PubMed id 14733360)1 Cho K.H....Jeong T.S. (2003)
- Structural basis for bile acid binding and activation of the nuclear receptor FXR. (PubMed id 12718893)1 Mi L.Z....Rastinejad F. (2003)
- Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. (PubMed id 12929628)1 Nicolaou K.C....Pfefferkorn J.A. (2003)
- Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR). (PubMed id 12749886)1 Costantino G....Pellicciari R. (2003)
- Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. (PubMed id 11927623)1 Claudel T....Staels B. (2002)
- Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2. (PubMed id 11735223)1 Kirkpatrick L.L....Nelson D.L. (2001)
- A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. (PubMed id 11030332)1 Goodwin B....Kliewer S.A. (2000)
- Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P. (PubMed id 10527928)1 Tamanini F....Hoogeveen A.T. (1999)
- Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. (PubMed id 8668200)1 Siomi M.C....Dreyfuss G. (1996)
- Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription. (PubMed id 10982880)1 del Castillo-Olivares A. and Gil G. (year=2000;month=Sep;day=15)
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