NR1H3 Gene
protein-coding GIFtS: 62
GCID: GC11P047269
|
|
nuclear receptor subfamily 1, group H, member 3
| |
Aliases
for NR1H3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Subfamily 1, Group H, Member 31 2 | | Liver X Nuclear Receptor Alpha Variant 12 | | LXR-A1 | | Oxysterols Receptor LXR-Alpha2 | | RLD-11 2 | | Liver X Receptor Alpha3 | | LXRA2 3 | | Nuclear Receptor Subfamily 1 Group H Member 33 |
Export aliases for NR1H3 gene to outside databasesPrevious GC identifers: GC11P049220 GC11P048157 GC11P047302 GC11P047245 GC11P047243 GC11P047236 GC11P046969 |
Summaries
for NR1H3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NR1H3:
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 familymembers are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasisand inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It formsa heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid responseelements. Studies in mice lacking this gene suggest that it may play an important role in the regulation ofcholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: NR1H3_HUMAN, Q13133Function: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an activeligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-typeresponse elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides.Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake throughMYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity)
 summary
for NR1H3: Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated
nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There
are two closely related isoforms of each of these enzymes; LXRalpha and LXRbeta, and FXRalpha and FXRbeta
(pseudogene in man). LXRalpha and FXRalpha expression is restricted to the liver, small intestine, kidney
and adrenal gland, whilst LXRbeta and FXRbeta are ubiquitously expressed. Despite acting on some of the same
target genes, including cholesterol 7alpha-hydroxylase (CYP7A1) and SREBP-1c, LXRs and FXRs have different
physiological roles. LXRs are involved in cholesterol homeostasis, inhibition of proinflammatory gene
expression in atherosclerosis and activation of innate immunity, whilst FXRs have a vital function in bile
acid homeostasis.
Gene Wiki entry for NR1H3 (Liver X receptor alpha)
|
Genomic Views
for NR1H3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR1H3 gene promoter:
COUP-TF1 COUP-TF COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR1H3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1H3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2NR1H3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P047269: view genomic region
(about GC identifiers)
Start:
|
47,269,851 bp from pter |
End:
|
47,290,401 bp from pter |
Size:
|
20,551 bases |
Orientation:
|
plus strand |
|
Proteins
for NR1H3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR1H3_HUMAN, Q13133 (See
protein sequence)Recommended Name: Oxysterols receptor LXR-alpha Size: 447 amino acids; 50396 Da
Subunit: Heterodimer of LXRA and RXR
Subcellular location: Nucleus (Potential)
4 PDB 3D structures from  and Proteopedia  for NR1H3:1UHL (3D)
3IPQ (3D)
3IPS (3D)
3IPU (3D)
Secondary accessions: A8K3J9 D3DQR1 Q8IW13 Q96H87Alternative splicing: 3 isoforms: Q13133-1 Q13133-2 Q13133-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NR1H3: NX_Q13133
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13133
NR1H3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (5 alternative transcripts):
NP_001123573.1 NP_001123574.1 NP_001238863.1 NP_001238864.1 NP_005684.2
ENSEMBL proteins: ENSP00000378793 ENSP00000385073 ENSP00000433271 ENSP00000403798 ENSP00000434650 ENSP00000385801 ENSP00000391005 ENSP00000413095 ENSP00000412636 ENSP00000415591 ENSP00000407716 ENSP00000387946 ENSP00000396132 ENSP00000403696 ENSP00000420656 ENSP00000406692 ENSP00000384745 ENSP00000432073 Reactome Protein details: Q13133
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NR1H3 for ontologies About GeneDecksing
NR1H3 Antibody Products:
Assay Products for NR1H3: |
Protein
Domains /
Families
for NR1H3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR1H3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13133ProtoNet protein and cluster: Q13133 1 Blocks protein family: IPB001723 Steroid hormone receptor signature
UniProtKB/Swiss-Prot: NR1H3_HUMAN, Q13133Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for NR1H3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NR1H3_HUMAN, Q13133Function: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an activeligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-typeresponse elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides.Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake throughMYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity)Induction: By 9-cis retinoic acid (9CRA)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NR1H3 (NM_005693) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR1H3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1H3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1H3 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
TAS | 7744246 | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0003707 | steroid hormone receptor activity |
IEA | -- | | GO:0003713 | transcription coactivator activity |
TAS | 7744246 | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
IEA | -- |
NR1H3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NR1H3:
Animal Models:
Mouse knock-outs for NR1H3: Nr1h3tm1Dgen Nr1h3tm1.1Gstr Nr1h3tm1.1Nph Nr1h3tm1Djm
14 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Nr1h3):
NR1H3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NR1H3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Nuclear Receptor transcription pathway | | | 3 | Nuclear receptors in lipid metabolism and toxicity | | | 4 | Adipogenesis | | | 5 | Hepatitis C | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for NR1H3
3 
Reactome Pathways for NR1H3
2 
Kegg Pathways (Kegg details for NR1H3):
NR1H3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR1H3
5/33 Interacting proteins for NR1H3 (Q131331, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 33)About this table
Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0006629 | lipid metabolic process |
-- | -- |
NR1H3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR1H3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NR1H3 for compounds About GeneDecksing
Compounds for NR1H3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| GW 3965 hydrochloride | Orally active liver X receptor (LXR) agonist | [405911-09-3] | | T 0901317 | Potent liver X receptor (LXR) agonist | [293754-55-9] |
4 DrugBank Compounds for NR1H3 About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID | -- | -- | target | -- | 10592235 | | 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE | -- | -- | target | -- | 10592235 | | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | -- | -- | target | -- | 10592235 | | N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE | -- | -- | target | -- | 10592235 |
10/14 Novoseek chemical compound relationships for NR1H3 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sterol |
82.3 |
18 |
19962449 (1), 20032471 (1), 12230796 (1), 12617469 (1) (see all 16) |
| cholesterol |
76 |
56 |
15280160 (2), 10936612 (1), 15539633 (1), 17845217 (1) (see all 46) |
| cholesterol ester |
65.4 |
1 |
18270459 (1) |
| lipid |
63.8 |
31 |
17217555 (2), 12700342 (1), 14703507 (1), 17154100 (1) (see all 25) |
| lanosterol |
60.4 |
2 |
18676367 (1), 20037138 (1) |
| fatty acid |
52.8 |
8 |
12917410 (1), 19885625 (1), 20032471 (1), 12617469 (1) (see all 7) |
| atorvastatin |
36.8 |
2 |
18427282 (1), 17644777 (1) |
| atp |
29.5 |
6 |
17767055 (1), 12632092 (1), 15769938 (1), 16311343 (1) (see all 6) |
| retinoic acid |
28.1 |
2 |
12632092 (1), 15615782 (1) |
| glucose |
27.9 |
5 |
12970362 (1), 16973760 (1), 19292929 (1), 15708349 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about NR1H3
|
Transcripts
for NR1H3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR1H3 gene (5 alternative transcripts): NM_001130101.2 NM_001130102.2 NM_001251934.1 NM_001251935.1 NM_005693.3 Unigene Cluster for NR1H3: Nuclear receptor subfamily 1, group H, member 3 Hs.438863 [show with all ESTs]Unigene Representative Sequence: AK12266118/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34): ENST00000495866 ENST00000527464 ENST00000529540(uc010rhk.2 uc009yll.2)
ENST00000395397 ENST00000405576 ENST00000481020 ENST00000481889(uc001nek.3)
ENST00000436778 ENST00000487913 ENST00000531660 ENST00000532630 ENST00000407404
ENST00000444396 ENST00000457932 ENST00000412937 ENST00000449369 ENST00000486991
ENST00000419652
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NR1H3 (NM_005693) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR1H3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1H3 |
Additional cDNA sequence: AB307698.1 AK122661.1 AK290614.1 AK302132.1 AK309027.1 AK311590.1 AK313311.1 BC008819.2 BC041172.1 BT019411.1 HQ692819.1 U22662.1 24/32 DOTS entries (see all 32): DT.120730649 DT.414781 DT.100026354 DT.99967362 DT.414782 DT.120730684 DT.120730568 DT.100787250 DT.99982968 DT.100787248 DT.92324908 DT.120730673 DT.75172113 DT.92036313 DT.95129136 DT.120730569 DT.120730654 DT.120730662 DT.95129127 DT.100787249 DT.100787254 DT.120730603 DT.120730646 DT.120730701 24/196 AceView cDNA sequences (see all 196): BM855407 BM560055 CR606496 AI288682 AI521157 BI521046 BE542999 BC041172 BP338102 CA405845 CR619974 BM835230 AI985346 AW770753 CR607859 CR618031 CB529591 CR615123 AI927058 CD368779 AW590068 AI703008 CA445177 BP381781
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for NR1H3 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | · | 3g | · | 3h | · | 3i | · | 3j | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 9c | · | 9d | · | 9e | · | 9f | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NR1H3
|
Expression
for NR1H3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR1H3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGACTGAT
About this image
Genevestigator expression for NR1H3
SOURCE GeneReport for Unigene cluster: Hs.438863
UniProtKB/Swiss-Prot: NR1H3_HUMAN, Q13133Tissue specificity: Visceral organs specific expression. Strong expression was found in liver, kidney and intestinefollowed by spleen and to a lesser extent the adrenals
SABiosciences Expression via Pathway-Focused PCR Arrays including NR1H3 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR1H3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR1H3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1H3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1H3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1H3 |
Orthologs
for NR1H3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NR1H3 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for NR1H3 (if available)
TreeFam Gene Tree for NR1H3 (if available) |
Paralogs
for NR1H3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NR1H3 gene
- VDR2 NR4A32 NR4A12 NR1I22 RARG2 NR1I32 THRB2 RARA2
- NR1H22 NR4A22 NR1H42 RARB2 THRA2
18/41 SIMAP similar genes for NR1H3 using alignment to 16 protein entries: NR1H3_HUMAN (see all proteins)
(see all similar genes):NR3C2 VDR NR2C2 HNF4G NR5A2 NR1H2
HNF4alpha ESRRG ESR1 RXRB DKFZp686D1580 THRB
NR1F1 RORC ESR2 NR1I3 NR6A1 THRA
NR1H3 for paralogs About GeneDecksing
|
Genomic Variants
for NR1H3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NR1H3 (47269851 - 47290401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NR1H3: --
Human Gene Mutation Database (HGMD): NR1H3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR1H3 |
|
Disorders
/ Diseases
for NR1H3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NR1H3 for disorders About GeneDecksing
OMIM gene information: 602423
OMIM disorders: --
20/39  diseases for NR1H3 (see all 39): About MalaCardsacth-secreting pituitary adenoma cholesterol maturity-onset diabetes of the young atherosclerosis
pulmonary alveolar proteinosis familial combined hyperlipidemia myxoid liposarcoma coronary heart disease
pituitary adenoma fatty liver disease hypobetalipoproteinemia liposarcoma
chronic lymphocytic leukemia lymphocytic leukemia hyperlipidemia rickets
liver disease hepatitis c adenoma vitiligo
1 disease from the University of Copenhagen DISEASES database for NR1H3:Atherosclerosis 5 Novoseek disease relationships for NR1H3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: NR1H3 (18 documents)
Export disorders for NR1H3 gene to outside databases
|
Publications
for NR1H3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR1H3 gene, integrated from 9 sources (see all 295):
(articles sorted by number of sources associating them with NR1H3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- LXR, a nuclear receptor that defines a distinct retinoid response pathway. (PubMed id 7744246)1, 2, 3 Willy P.J....Mangelsdorf D.J. (1995)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. (PubMed id 8621574)1, 3 Miyata K.S....Capone J.P. (1996)
- Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations. (PubMed id 18209740)1, 9 Legry V....Meirhaeghe A. (2008)
- Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. (PubMed id 18276933)1, 9 Henry-Berger J....Caira F. (2008)
- Liver X receptor alpha associates with human life span. (PubMed id 17452725)1, 9 Mooijaart S.P....van Heemst D. (2007)
- Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha. (PubMed id 18024509)1, 9 Stayrook K.R....Burris T.P. (2008)
- Protein kinase C alpha modulates liver X receptor alpha transactivation. (PubMed id 18372238)1, 9 Delvecchio C.J. and Capone J.P. (2008)
- Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages. (PubMed id 18250151)1, 9 Torra I.P....Garabedian M.J. (2008)
|
External Searches for NR1H3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NR1H3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NR1H3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NR1H3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NR1H3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NR1H3 gene:
Search GeneIP for patents involving NR1H3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NR1H3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NR1H3 | | OriGene shRNA RFP for NR1H3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR1H3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR1H3 | | | OriGene Protein Over-expression Lysate for NR1H3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NR1H3 | | OriGene 3'-UTR Clone for NR1H3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NR1H3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NR1H3 | | OriGene Custom Protein Services for NR1H3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR1H3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR1H3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1H3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR1H3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1H3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1H3 |
| |
 |  |  |  | |
| | | | Tocris compounds for NR1H3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1H3 |
|  |  |  | | | | ThermoFisher Antibody for NR1H3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1H3 |
|
|
|
|
