NR1H2 Gene
protein-coding GIFtS: 63
GCID: GC19P050879
|
|
nuclear receptor subfamily 1, group H, member 2(Previous name: ubiquitously-expressed nuclear receptor )
(Previous symbol: UNR)
| |
Aliases
for NR1H2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Subfamily 1, Group H, Member 21 2 | | LXRB2 3 | | UNR1 2 3 5 | | Liver X Nuclear Receptor Beta2 | | Ubiquitously-Expressed Nuclear Receptor1 2 3 | | LX Receptor Beta2 | | NER1 2 3 | | Nuclear Orphan Receptor LXR-Beta2 | | LXR-B1 | | Oxysterols Receptor LXR-Beta2 | | NER-I1 2 | | Steroid Hormone-Nuclear Receptor NER2 | | RIP151 2 | | Liver X Receptor Beta3 | | Nuclear Receptor NER2 3 | | Nuclear Receptor Subfamily 1 Group H Member 23 |
Export aliases for NR1H2 gene to outside databasesPrevious GC identifers: GC19P051508 GC19P051241 GC19P055508 GC19P055571 GC19P047217 |
Summaries
for NR1H2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NR1H2:
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and arekey regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis andinflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages,lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers withretinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements(summary by Korf et al., 2009 (PubMed 19436111)).(supplied by OMIM, Jan 2010)
UniProtKB/Swiss-Prot: NR1H2_HUMAN, P55055Function: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensushalf-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependentubiquitination of LDLR, VLDLR and LRP8 (By similarity)
 summary
for NR1H2: Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated
nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There
are two closely related isoforms of each of these enzymes; LXRalpha and LXRbeta, and FXRalpha and FXRbeta
(pseudogene in man). LXRalpha and FXRalpha expression is restricted to the liver, small intestine, kidney
and adrenal gland, whilst LXRbeta and FXRbeta are ubiquitously expressed. Despite acting on some of the same
target genes, including cholesterol 7alpha-hydroxylase (CYP7A1) and SREBP-1c, LXRs and FXRs have different
physiological roles. LXRs are involved in cholesterol homeostasis, inhibition of proinflammatory gene
expression in atherosclerosis and activation of innate immunity, whilst FXRs have a vital function in bile
acid homeostasis.
Gene Wiki entry for NR1H2 (Liver X receptor beta)
|
Genomic Views
for NR1H2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR1H2 gene promoter:
Elk-1 HOXA3 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR1H2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1H2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3NR1H2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050879: view genomic region
(about GC identifiers)
Start:
|
50,832,949 bp from pter |
End:
|
50,886,267 bp from pter |
Size:
|
53,319 bases |
Orientation:
|
plus strand |
|
Proteins
for NR1H2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR1H2_HUMAN, P55055 (See
protein sequence)Recommended Name: Oxysterols receptor LXR-beta Size: 460 amino acids; 50974 Da
Subunit: Forms a heterodimer with RXR
Subcellular location: Nucleus (Potential)
6/10 PDB 3D structures from  and Proteopedia  for NR1H2 (see all 10):1P8D (3D)
1PQ6 (3D)
1PQ9 (3D)
1PQC (3D)
1UPV (3D)
1UPW (3D)
Secondary accessions: A8K490 Q12970 Q5I0Y1Explore the universe of human proteins at neXtProt for NR1H2: NX_P55055
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55055
NR1H2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243576.1 NP_009052.3
ENSEMBL proteins: ENSP00000253727 ENSP00000396151 ENSP00000445074 Reactome Protein details: P55055
Human Recombinant Protein Products for NR1H2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NR1H2 for ontologies About GeneDecksing
NR1H2 Antibody Products:
Assay Products for NR1H2: |
Protein
Domains /
Families
for NR1H2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR1H2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P55055ProtoNet protein and cluster: P55055 2 Blocks protein families: IPB000324 Vitamin D receptor signature IPB001723 Steroid hormone receptor signature
UniProtKB/Swiss-Prot: NR1H2_HUMAN, P55055Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for NR1H2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NR1H2_HUMAN, P55055Function: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensushalf-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependentubiquitination of LDLR, VLDLR and LRP8 (By similarity) Genatlas biochemistry entry for NR1H2:nuclear receptor subfamily 1,group H,member2,modulating gene activation by retinoic acid and thyroid hormone receptors
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001133 | sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity |
IEA | -- | | GO:0003677 | DNA binding |
TAS | 7926814 | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0003707 | steroid hormone receptor activity |
IEA | -- | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
IEA | -- |
NR1H2 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for NR1H2:
15/16 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Nr1h2) (see all 16):
NR1H2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for NR1H2: Nr1h2tm1Dgen Nr1h2tm1.1Gstr Nr1h2tm1.1Nph Nr1h2tm1Djm
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NR1H2 (NM_007121) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR1H2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1H2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1H2 |
|
Pathways & Interactions
for NR1H2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Nuclear Receptor transcription pathway | | | 3 | Regulation of Cholesterol Biosynthesis by SREBP (SREBF) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NR1H2
3 
Reactome Pathways for NR1H2
NR1H2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR1H2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/87 Interacting proteins for NR1H2 (P550551, 2, 3 ENSP000002537274) via UniProtKB, MINT, STRING, and/or I2D (see all 87)About this table
Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
-- | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- |
NR1H2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR1H2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NR1H2 for compounds About GeneDecksing
Compounds for NR1H2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| GW 3965 hydrochloride | Orally active liver X receptor (LXR) agonist | [405911-09-3] | | T 0901317 | Potent liver X receptor (LXR) agonist | [293754-55-9] |
4 DrugBank Compounds for NR1H2 About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| (3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid | -- | -- | target | -- | 17139284 17016423 | | Benzenesulfonyl | -- | -- | target | -- | 17139284 17016423 | | 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL | -- | -- | target | -- | 10592235 | | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | -- | -- | target | -- | 10592235 |
10/121 Novoseek chemical compound relationships for NR1H2 gene (see all 121) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| androstane |
90.8 |
55 |
16399345 (2), 17132852 (2), 11981033 (2), 18362160 (2) (see all 49) |
| retinoic acid |
89.7 |
498 |
20123735 (3), 1712634 (3), 1328967 (2), 10567404 (2) (see all 99) |
| retinoid |
88.3 |
135 |
10331664 (2), 17320364 (2), 10876107 (2), 18632669 (2) (see all 99) |
| steroid |
84.1 |
337 |
11757905 (7), 19541426 (4), 19207820 (4), 19401208 (3) (see all 99) |
| estrogen |
81.2 |
193 |
18276948 (2), 14967140 (2), 2340506 (2), 9717844 (2) (see all 99) |
| vitamin d |
79.8 |
149 |
17132852 (2), 9263679 (2), 19910507 (2), 15663994 (2) (see all 99) |
| gw 3965 |
74.7 |
1 |
12819202 (1) |
| ttnpb |
73.7 |
4 |
10996432 (1), 18162363 (1), 11850224 (1) |
| rosiglitazone |
72.6 |
8 |
11185675 (1), 15242346 (1), 11438523 (1), 12767049 (1) (see all 8) |
| ecdysone |
69.4 |
20 |
18342247 (2), 9466931 (1), 16264191 (1), 20093179 (1) (see all 19) |
Search CenterWatch for drugs/clinical trials and news about NR1H2
|
Transcripts
for NR1H2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR1H2 gene (2 alternative transcripts): NM_001256647.1 NM_007121.5 Unigene Cluster for NR1H2: Nuclear receptor subfamily 1, group H, member 2 Hs.432976 [show with all ESTs]Unigene Representative Sequence: AK0915353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253727(uc010enw.3) ENST00000411902 ENST00000542413(uc002prv.4 uc002psa.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR1H2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NR1H2 (NM_007121) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR1H2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1H2 |
Additional cDNA sequence: AB307697.1 AK091535.1 AK290855.1 AK297978.1 BC007790.1 BC033500.1 BC047750.2 BC074500.1 CR456706.1 CR749648.1 HQ692835.1 U07132.1 U14534.1 23 DOTS entries: DT.448580 DT.100885856 DT.100885860 DT.100885855 DT.100885843 DT.102835618 DT.121420513 DT.100038302 DT.121420447 DT.121420503 DT.100885848 DT.91760893 DT.97862333 DT.100038299 DT.100837391 DT.100885841 DT.100885858 DT.121420499 DT.91760886 DT.91793298 DT.97862334 DT.100885863 DT.92369219 24/503 AceView cDNA sequences (see all 503): CR609885 BX490437 BF725106 BI859081 BF726063 CR604070 BQ953936 BI826244 CR592437 AI970022 CR598123 BQ067532 BI767687 BQ436846 CR603617 AI752434 BM716607 BQ222200 CA487853 BQ212165 BM559462 BX101626 AA359408 BQ923511
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NR1H2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for NR1H2
|
Expression
for NR1H2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR1H2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCTCCCCC
About this image
See NR1H2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR1H2
SOURCE GeneReport for Unigene cluster: Hs.432976
UniProtKB/Swiss-Prot: NR1H2_HUMAN, P55055Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including NR1H2: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat | | Nuclear Receptors & Coregulators in human mouse rat | | Fatty Liver in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR1H2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR1H2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1H2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1H2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1H2 |
Orthologs
for NR1H2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NR1H2 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
NR1H26 |
-- |
78(a) |
1 ↔ 1 |
6(79748994-79759951) |
fruit fly
(Drosophila melanogaster) |
Insecta |
EcR3 |
imaginal disc eversion ecdysteroid hormone
receptor |
38(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
nhr-486nhr-86(see all 3) |
Nuclear hormone receptor family member nhr-8(see all 3) |
9(a)13(a)(see all 3) |
possible orthologpossible ortholog(see all 3) |
X(15708153-15716345) IV(7710977-7714670) |
ENSEMBL Gene Tree for NR1H2 (if available)
TreeFam Gene Tree for NR1H2 (if available) |
Paralogs
for NR1H2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NR1H2 gene
- VDR2 NR4A32 NR4A12 NR1I22 RARG2 NR1I32 THRB2 RARA2
- NR4A22 NR1H42 RARB2 THRA2 NR1H32
18/32 SIMAP similar genes for NR1H2 using alignment to 13 protein entries: NR1H2_HUMAN (see all proteins)
(see all similar genes):DKFZp686D1580 NR3C2 NR1H3 HNF4G NR1D2 VDR
NR5A1 HNF4alpha ESR1 NR1I3 NR1F1 NR1I1
DKFZp686P04237 NR1i1 NR1H4 NR1A2 RARG THRB
NR1H2 for paralogs About GeneDecksing
|
Genomic Variants
for NR1H2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): NR1H2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR1H2 |
|
Disorders
/ Diseases
for NR1H2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NR1H2 for disorders About GeneDecksing
OMIM gene information: 600380
OMIM disorders: --
20/150  diseases for NR1H2 (see all 150): About MalaCardsdosage-sensitive sex reversal acyl-coa dehydrogenase androgen insensitivity syndrome acth-secreting pituitary adenoma
complete androgen insensitivity syndrome estrogen-receptor positive breast cancer extraskeletal myxoid chondrosarcoma sex reversal
atherosclerosis attention deficit hyperactivity disorder retinol binding protein cerebrotendinous xanthomatosis
maturity-onset diabetes of the young cholesterol myxoid chondrosarcoma non-small cell lung carcinoma
polycystic ovary syndrome seborrheic keratosis familial combined hyperlipidemia thyroid hormone resistance syndrome
10/94 Novoseek disease relationships for NR1H2 gene (see all 94) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia promyelocytic acute |
63.1 |
8 |
9108090 (1), 17699721 (1), 9531570 (1), 15942830 (1) (see all 8) |
| thyroid hormone resistance |
56.6 |
3 |
11845213 (1), 15579758 (1) |
| breast cancer |
54.4 |
66 |
20008677 (4), 10996432 (4), 12656669 (2), 18417735 (2) (see all 52) |
| atherosclerosis |
53.8 |
23 |
14671562 (1), 18375823 (1), 19243223 (1), 12364466 (1) (see all 22) |
| insulin sensitivity |
51.6 |
19 |
11516972 (1), 16050954 (1), 16328782 (1), 12163159 (1) (see all 19) |
| cholestasis |
51.6 |
17 |
20388526 (2), 16749856 (1), 16565602 (1), 18377365 (1) (see all 14) |
| dyslipidemia |
50.1 |
10 |
15922648 (2), 17084281 (1), 16870465 (1), 20388526 (1) (see all 9) |
| metabolic disorder |
50.1 |
11 |
16316322 (2), 17876520 (1), 17096060 (1), 17162257 (1) (see all 10) |
| insulin resistance |
48.1 |
14 |
11715152 (1), 18430774 (1), 18645617 (1), 15922648 (1) (see all 14) |
| inflammation |
46.6 |
72 |
18650918 (3), 16760748 (2), 18433989 (2), 11375111 (1) (see all 66) |
Human Genome Epidemiology (HuGE) Navigator: NR1H2 (17 documents)
Export disorders for NR1H2 gene to outside databases
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Publications
for NR1H2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR1H2 gene, integrated from 9 sources (see all 2280):
(articles sorted by number of sources associating them with NR1H2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. (PubMed id 12819202)1, 2, 9 Farnegardh M.... Carlquist M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization. (PubMed id 7782080)1, 3 Le Beau M.M....Liao S. (1995)
- Ubiquitous receptor: a receptor that modulates gene a ctivation by retinoic acid and thyroid hormone receptors. (PubMed id 7971966)1, 3 Song C....Liao S. (1994)
- NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. (PubMed id 7926814)1, 2 Shinar D.M.... Schmidt A. (1994)
- Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study. (PubMed id 19292929)1, 9 Dahlman I....Steffensen K.R. (2009)
- Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. (PubMed id 17108812)1, 9 Dahlman I....Dahlman-Wright K. (2006)
- Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. (PubMed id 11158331)1, 9 Lee S.K....Lee J.W. (2001)
- Liver X receptors interact with corepressors to regulate gene expression. (PubMed id 12663743)1, 9 Hu X....Lala D.S. (2003)
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External Searches for NR1H2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NR1H2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing NR1H2 gene
(According to HUGE)
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| -- |
Specialized Databases showing NR1H2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for NR1H2 gene:
Search GeneIP for patents involving NR1H2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NR1H2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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