Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NR1D2 Gene

protein-coding   GIFtS: 57
GCID: GC03P023961

Nuclear Receptor Subfamily 1, Group D, Member 2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Receptor Subfamily 1, Group D, Member 21 2     Nuclear Receptor Rev-ErbA Beta Variant 12
RVR2 3 5     Nuclear Receptor Rev-ErbA Beta Variant 22
Orphan Nuclear Hormone Receptor BD732 3     Nuclear Receptor Subfamily 1 Group D Member 22
Rev-Erb Alpha-Related Receptor2 3     rev-erb-beta2
EAR-1R2 3     Rev-Erba-Alpha-Related Receptor2
V-ErbA-Related Protein 1-Related2 3     Rev-erb-beta3
BD732 5     

External Ids:    HGNC: 79631   Entrez Gene: 99752   Ensembl: ENSG000001747387   OMIM: 6023045   UniProtKB: Q149953   

Export aliases for NR1D2 gene to outside databases

Previous GC identifers: GC03U990106 GC03P023669 GC03P023836


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NR1D2 Gene:
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors.
The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and
carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. (provided by
RefSeq, Feb 2009)

GeneCards Summary for NR1D2 Gene:
NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein-coding gene. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995
Function: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent
manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a
critical negative limb of the circadian clock by directly repressing the expression of core clock components
BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the
inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3
corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within
the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of
the response element. Binds as a monomer to a response element composed of the consensus half-site motif
5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core
motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function
and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal
muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3,
SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a
distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its
activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the
sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the
skeletal muscle

Gene Wiki entry for NR1D2 (Rev-ErbA beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR1D2 gene promoter:
         Pbx1a   NF-kappaB   NF-kappaB1   Pax-4a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR1D2 promoter sequence
   Search Chromatin IP Primers for NR1D2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR1D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

NR1D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1D2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023961:  view genomic region     (about GC identifiers)

Start:
23,986,751 bp from pter      End:
24,022,109 bp from pter
Size:
35,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 1 group D member 2  
Size: 579 amino acids; 64625 Da
Subunit: Binds DNA as a monomer or a homodimer. Interacts with NCOA5 coactivator, leading to a strong increase of
transcription of target genes. Interacts (via N-terminus) with KAT5. Interacts (via C-terminus) with HDAC1.
Interacts with ZNHIT1
3 PDB 3D structures from and Proteopedia for NR1D2:
2V0V (3D)        2V7C (3D)        3CQV (3D)    
Secondary accessions: B2R8Q3 O00402 Q86XD4

Explore the universe of human proteins at neXtProt for NR1D2: NX_Q14995

Explore proteomics data for NR1D2 at MOPED

Post-translational modifications: 

  • Deacetylated by HDAC1. Acetylation and deacetylation regulate its transcriptional regulatory activity1
  • Under more reducing intracellular redox conditions, Cys-384 is in its heme-bound state, which is optimal for
    recruitment of the NCOR1/HDAC3 corepressor complex and repression of target genes. When subjected to oxidative
    stress conditions, Cys-384 undergoes oxidation to form a disulfide bridge with Cys-374, also triggering a ligand
    switch that results in release of bound heme and derepression of target genes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR1D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138897.1  NP_005117.3  

    ENSEMBL proteins: 
     ENSP00000310006   ENSP00000373283  
    Reactome Protein details: Q14995

    NR1D2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NR1D2
    OriGene Protein Over-expression Lysate for NR1D2
    OriGene MassSpec for NR1D2
    OriGene Custom Protein Services for NR1D2
    GenScript Custom Purified and Recombinant Proteins Services for NR1D2
    Novus Biologicals NR1D2 Protein
    Novus Biologicals NR1D2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NR1D2

     
    Search eBioscience for Proteins for NR1D2 

    NR1D2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NR1D2 (Rev-erb beta/NR1D2)
    OriGene Antibodies for NR1D2
    OriGene Custom Antibody Services for NR1D2
    Novus Biologicals NR1D2 Antibodies
    Abcam antibodies for NR1D2
    Cloud-Clone Corp. Antibodies for NR1D2
    ThermoFisher Antibodies for NR1D2
    LSBio Antibodies in human, mouse, rat for NR1D2

    NR1D2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NR1D2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NR1D2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NR1D2
    Cloud-Clone Corp. CLIAs for NR1D2
    Search eBioscience for ELISAs for NR1D2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rev-Erb-beta
    1D. Rev-Erb receptors

    5 InterPro protein domains:
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14995

    ProtoNet protein and cluster: Q14995

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR1D2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR1D2_HUMAN, Q14995
    Function: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent
    manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a
    critical negative limb of the circadian clock by directly repressing the expression of core clock components
    BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the
    inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3
    corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within
    the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of
    the response element. Binds as a monomer to a response element composed of the consensus half-site motif
    5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core
    motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function
    and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal
    muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3,
    SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a
    distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its
    activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the
    sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the
    skeletal muscle
    Enzyme regulation: The heme-bound form can bind gaseous signaling molecules such as CO and nitric oxide (NO) and
    NO can reverse its transcriptional repressor activity

         Genatlas biochemistry entry for NR1D2:
    nuclear receptor subfamily 1,group D,member 2,in a duplicated region including THRB and RARB in a region paralog
    to a region of chromosome 17q11.12 including THRA,NR1D1,RARA

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001046core promoter sequence-specific DNA binding IDA17892483
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS7997240
         
    Find genes that share ontologies with NR1D2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nr1d2):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     normal  other  vision/eye 

    Find genes that share phenotypes with NR1D2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nr1d2tm1.2Rev for NR1D2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR1D2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR1D2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR1D2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR1D2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NR1D2:
    hsa-mir-10a-5p (MIRT025595), hsa-mir-132-3p (MIRT021733), hsa-mir-125a-5p (MIRT021292), hsa-mir-744-5p (MIRT037578)

    Block miRNA regulation of human, mouse, rat NR1D2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR1D2 (see all 97):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-938 hsa-miR-485-3p hsa-miR-128 hsa-miR-502-3p hsa-miR-3148 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidNR1D2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR1D2
    Predesigned siRNA for gene silencing in human, mouse, rat NR1D2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR1D2

    Clone
    Products:
         
    OriGene clones in human, mouse for NR1D2 (see all 12)
    OriGene ORF clones in mouse, rat for NR1D2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NR1D2 (NM_005126)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR1D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D2
    Addgene plasmids for NR1D2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NR1D2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NR1D2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NR1D2_HUMAN, Q14995: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7997240
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with NR1D2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NR1D2 About    
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with NR1D2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NR1D2
        Diurnally regulated genes with circadian orthologs
    Nuclear Receptors

    1 Reactome Pathway for NR1D2
        Nuclear Receptor transcription pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR1D2: 
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR1D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR1D2 (Q149951, 3 ENSP000003100064) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1D1P203933, ENSP000002466724I2D: score=2 STRING: ENSP00000246672
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    NCOR1O753763, ENSP000002687124I2D: score=2 STRING: ENSP00000268712
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    KAT5Q929933, ENSP000003403304I2D: score=1 STRING: ENSP00000340330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated TAS7997240
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0019216regulation of lipid metabolic process ISS--

    Find genes that share ontologies with NR1D2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR1D2

    1 IUPHAR Ligand for NR1D2 (Rev-Erb-beta)    About this table
    LigandTypeActionAffinityPubmed IDs
    heme
    AgonistAgonist18006707 18037887



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NR1D2 gene (2 alternative transcripts): 
    NM_001145425.1  NM_005126.4  

    Unigene Cluster for NR1D2:

    Nuclear receptor subfamily 1, group D, member 2
    Hs.37288  [show with all ESTs]
    Unigene Representative Sequence: NM_005126
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312521(uc003ccs.2 uc010hfd.2 uc011awk.1) ENST00000383773
    ENST00000492552 ENST00000468700 ENST00000472780
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NR1D2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR1D2 (see all 97):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-938 hsa-miR-485-3p hsa-miR-128 hsa-miR-502-3p hsa-miR-3148 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidNR1D2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NR1D2
    Predesigned siRNA for gene silencing in human, mouse, rat NR1D2
    Clone
    Products:
         
    OriGene clones in human, mouse for NR1D2 (see all 12)
    OriGene ORF clones in mouse, rat for NR1D2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NR1D2 (NM_005126)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR1D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D2
    Addgene plasmids for NR1D2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NR1D2
    OriGene qSTAR qPCR primer pairs in human, mouse for NR1D2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR1D2
      QuantiTect SYBR Green Assays in human, mouse, rat NR1D2
      QuantiFast Probe-based Assays in human, mouse, rat NR1D2

    Additional mRNA sequence: 

    AB209091.1 AB307693.1 AK293273.1 AK301925.1 AK313464.1 BC015929.1 BC045613.1 BC070035.1 
    BX537786.1 CR457434.1 D16815.1 HQ692830.1 HQ692831.1 L31785.1 

    9 DOTS entries:

    DT.95230991  DT.86837593  DT.411284  DT.100800113  DT.100821773  DT.120902203  DT.120902041  DT.120902284 
    DT.92362616 

    Selected AceView cDNA sequences (see all 170):

    AI761621 AW473152 BE501571 AI952370 CB133671 BM460536 BE217729 BQ189049 
    BQ214939 BM677622 BM068747 BE501581 AW026327 CA841730 AA425685 AI375425 
    AI803111 AA458841 BM054735 BM726115 CA312643 BE326398 BM682263 BQ012458 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NR1D2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                -                                             
    SP2:                                -                 -                           
    SP3:                                                                              


    ECgene alternative splicing isoforms for NR1D2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NR1D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGAGAA
    NR1D2 Expression
    About this image

    NR1D2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR1D2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37288

    UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995
    Tissue specificity: Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and
    brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in
    peripheral tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR1D2: 
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NR1D2
    OriGene qSTAR qPCR primer pairs in human, mouse for NR1D2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR1D2
    QuantiTect SYBR Green Assays in human, mouse, rat NR1D2
    QuantiFast Probe-based Assays in human, mouse, rat NR1D2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NR1D2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr1d21 , 5 nuclear receptor subfamily 1, group D, member 21, 5 89.06(n)1
    91.32(a)1
      14 (7.08 cM)5
    3531871  NM_011584.41  NP_035714.31 
     182040545 
    chicken
    (Gallus gallus)
    Aves NR1D21 nuclear receptor subfamily 1, group D, member 2 79.41(n)
    83.92(a)
      396125  NM_205205.1  NP_990536.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR1D26
    nuclear receptor subfamily 1, group D, member 2
    75(a)
    1 ↔ 1
    GL343357.1(624515-655017)
    zebrafish
    (Danio rerio)
    Actinopterygii reverbb2 rev-erb-beta 75.6(n)   30271  AF342942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip75B6
    Ecdysone-induced protein 75B
    12(a)
    1 → many
    3L(17944053-18057796)
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-856
    sex-16
    Protein SEX-1 (sex-1) mRNA, complete cds
    24(a)
    22(a)
    many ↔ many
    many ↔ many
    I(13056091-13062122) WBGene00003675
    X(10201328-10205433) WBGene00004786


    ENSEMBL Gene Tree for NR1D2 (if available)
    TreeFam Gene Tree for NR1D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NR1D2 gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    RARB2  RORA2  RORB2  RORC2  NR1D12  NR1I32  PPARG2  NR1H22  
    THRA2  NR1H32  
    17 SIMAP similar genes for NR1D2 using alignment to 7 protein entries:     NR1D2_HUMAN (see all proteins):
    NR3C2    HNF4alpha    HNF4G    VDR    ESR1    NR1H2
    NR1D1    PPARG    RARG    NR1I3    RORA    NR1F1
    NR1F2    RORB    NR1F3    RORC    NR5A1

    Find genes that share paralogs with NR1D2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NR1D2 (see all 902)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156510381,2
    F--23926253(+) AAGGCT/CGTGAG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs41318641,2
    C,F,A,H--23926407(-) TAGAAG/TGTGGG 1 -- us2k121Minor allele frequency- T:0.22NS EA NA WA CSA 2348
    rs130872501,2
    C,F--23926436(+) CAAACT/AGGAAA 1 -- us2k14Minor allele frequency- A:0.38NA WA 8
    rs2013908901,2
    C--23926438(+) AACTG-/GAAA  
            
    GAGTT
    1 -- us2k10--------
    rs48585641,2
    C,F,A,H--23926450(+) TTTTAC/TAAGCA 1 -- us2k116Minor allele frequency- T:0.17NS EA NA WA 2094
    rs1400022081,2
    C--23926487(+) TAACAA/TCTTAC 1 -- us2k10--------
    rs1454125871,2
    --23926503(+) CATCTA/GTTCAT 1 -- us2k10--------
    rs1997560701,2
    --23926512(+) ATGCC-/TCTA  
            
    TCAGC
    1 -- us2k10--------
    rs1138281631,2
    F--23926526(+) CCATCC/TTACTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1473012151,2
    --23926538(+) AGTAAC/TGCGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NR1D2 (23986751 - 24022109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NR1D2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834638CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR1D2
    DNA2.0 Custom Variant and Variant Library Synthesis for NR1D2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602304    OMIM disorders: --


    Find genes that share disorders with NR1D2           About GenesLikeMe


    Export disorders for NR1D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NR1D2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NR1D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. (PubMed id 7997240)1, 2, 3 Dumas B.... Moore D.D. (Mol. Endocrinol. 1994)
    2. Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}. (PubMed id 21123168)1, 2 Gupta N. and Ragsdale S.W. (J. Biol. Chem. 2011)
    3. The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. (PubMed id 17996965)1, 2 Wang J....Lu H. (Biochim. Biophys. Acta 2008)
    4. Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta. (PubMed id 17870090)1, 2 Woo E.-J.... Eon Ryu S. (J. Mol. Biol. 2007)
    5. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. (PubMed id 17892483)1, 2 Wang J....Lu H. (FEBS J. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PubMed id 11113208)1, 2 Sauve F....Giguere V. (Mol. Cell. Biol. 2001)
    8. Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication. (PubMed id 10198169)1, 3 Koh Y.S. and Moore D.D. (Genomics 1999)
    9. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. (PubMed id 18037887)1, 9 Raghuram S....Rastinejad F. (amp 2007)
    10. Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples. (PubMed id 22828941)1 Goumidi L....Meirhaeghe A. (Int J Obes (Lond) 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9975 HGNC: 7963 AceView: NR1D2 Ensembl:ENSG00000174738 euGenes: HUgn9975
    ECgene: NR1D2 H-InvDB: NR1D2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NR1D2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NR1D2 gene:
    Search GeneIP for patents involving NR1D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NR1D2 (Rev-erb beta/NR1D2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NR1D2   OriGene RNAi products in human, mouse, rat for NR1D2  
     OriGene qPCR primer pairs and template standards for NR1D2   OriGene Protein Over-expression Lysate for NR1D2  
     OriGene MassSpec something-or-other for NR1D2   OriGene clones in human, mouse for NR1D2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NR1D2   OriGene Purified Protein for NR1D2  
     OriGene ORF clones in mouse, rat for NR1D2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NR1D2   OriGene Custom Protein Services for NR1D2  

     
     
     Block miRNA regulation of human, mouse, rat NR1D2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NR1D2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR1D2 Predesigned siRNA for gene silencing in human, mouse, rat NR1D2
     QuantiFast Probe-based Assays in human, mouse, rat NR1D2 QuantiTect SYBR Green Assays in human, mouse, rat NR1D2
     PCR Arrays including human, mouse, rat NR1D2 Search Chromatin IP Primers for NR1D2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR1D2  GeneGlobe Interaction Network for NR1D2
     Regulatory tfbs in NR1D2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NR1D2 GenScript cDNA clones with any tag delivered in your preferred vector for NR1D2
     GenScript Custom Assay Services for NR1D2 GenScript Custom overexpressing Cell Line Services for NR1D2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NR1D2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NR1D2 antibodies
     NR1D2 proteins
     NR1D2 lysates
     Antibodies for NR1D2
     See all of Abcam's Antibodies, Kits and Proteins for NR1D2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NR1D2
     Antibodies for NR1D2
     ELISAs for NR1D2
     CLIAs for NR1D2



     Browse ESI BIO Cell Lines and PureStem Progenitors for NR1D2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D2
     SwitchGear 3'UTR luciferase reporter plasmids for NR1D2
     SwitchGear Promoter luciferase reporter plasmids for NR1D2
     ThermoFisher Antibodies for NR1D2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR1D2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR1D2
     LSBio Antibodies in human, mouse, rat for NR1D2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for NR1D2
      Search eBioscience for proteins for NR1D2
      Search eBioscience for elisas for NR1D2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NR1D2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4