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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR1D2 Gene

protein-coding   GIFtS: 57
GCID: GC03P023961

Nuclear Receptor Subfamily 1, Group D, Member 2

  Search for NR1D2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 1, Group D, Member 21 2     Nuclear Receptor Rev-ErbA Beta Variant 12
Orphan Nuclear Hormone Receptor BD732 3     Nuclear Receptor Rev-ErbA Beta Variant 22
EAR-1R2 3     Nuclear Receptor Subfamily 1 Group D Member 22
V-ErbA-Related Protein 1-Related2 3     rev-erb-beta2
BD732     Rev-Erba-Alpha-Related Receptor2
RVR2     Rev-erb-beta3

External Ids:    HGNC: 79631   Entrez Gene: 99752   Ensembl: ENSG000001747387   OMIM: 6023045   UniProtKB: Q149953   

Export aliases for NR1D2 gene to outside databases

Previous GC identifers: GC03U990106 GC03P023669 GC03P023836


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR1D2 Gene:
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors.
The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and
carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. (provided by
RefSeq, Feb 2009)

GeneCards Summary for NR1D2 Gene: 
NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein-coding gene. Among its related super-pathways are Nuclear Receptors and Gene Expression. GO annotations related to this gene include ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RORC.

UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995
Function: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3'. Acts as a potent competitive repressor
of ROR alpha function (By similarity)

Gene Wiki entry for NR1D2 (Rev-ErbA beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR1D2 gene promoter:
         Pbx1a   NF-kappaB   NF-kappaB1   Pax-4a   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR1D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR1D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.1

NR1D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1D2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023961:  view genomic region     (about GC identifiers)

Start:
23,986,751 bp from pter      End:
24,022,109 bp from pter
Size:
35,359 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 1 group D member 2  
Size: 579 amino acids; 64625 Da
Subunit: Interacts with NCOA5 coactivator, leading to a strong increase of transcription of target genes
Subcellular location: Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for NR1D2:
2V0V (3D)        2V7C (3D)        3CQV (3D)    
Secondary accessions: B2R8Q3 O00402 Q86XD4

Explore the universe of human proteins at neXtProt for NR1D2: NX_Q14995

Explore proteomics data for NR1D2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14995

  • NR1D2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NR1D2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138897.1  NP_005117.3  

    ENSEMBL proteins: 
     ENSP00000310006   ENSP00000373283  
    Reactome Protein details: Q14995
    Human Recombinant Protein Products for NR1D2: 
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    Cloud-Clone Corp. Proteins for NR1D2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7997240
    GO:0005654nucleoplasm TAS--

    NR1D2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rev-Erb-&beta 
    1D. Rev-Erb receptors

    5 InterPro protein domains:
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14995

    ProtoNet protein and cluster: Q14995

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR1D2_HUMAN, Q14995
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR1D2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR1D2_HUMAN, Q14995
    Function: Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3'. Acts as a potent competitive repressor
    of ROR alpha function (By similarity)

         Genatlas biochemistry entry for NR1D2:
    nuclear receptor subfamily 1,group D,member 2,in a duplicated region including THRB and RARB in a region paralog
    to a region of chromosome 17q11.12 including THRA,NR1D1,RARA

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS7997240
    GO:0005515protein binding IPI--
         
    NR1D2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nr1d2):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     normal  other  vision/eye 

    NR1D2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nr1d2tm1.2Rev for NR1D2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NR1D2 
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    SwitchGear 3'UTR luciferase reporter plasmidNR1D2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NR1D2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    3Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NR1D2
        Diurnally regulated genes with circadian orthologs
    Nuclear Receptors

    3        Reactome Pathways for NR1D2
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR1D2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR1D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for NR1D2 (Q149951, 3 ENSP000003100064) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000003702014I2D: score=1 STRING: ENSP00000370201
    NR1D1P203933, ENSP000002466724I2D: score=2 STRING: ENSP00000246672
    AK6Q165943I2D: score=1 
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    NCOR1O753763, ENSP000002687124I2D: score=2 STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent TAS7997240
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0030522intracellular receptor signaling pathway TAS7997240

    NR1D2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NR1D2

    1 IUPHAR Ligand for NR1D2 (Rev-Erb-&beta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    heme
    Agonist18006707 18037887

    Search CenterWatch for drugs/clinical trials and news about NR1D2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR1D2 gene (2 alternative transcripts): 
    NM_001145425.1  NM_005126.4  

    Unigene Cluster for NR1D2:

    Nuclear receptor subfamily 1, group D, member 2
    Hs.37288  [show with all ESTs]
    Unigene Representative Sequence: NM_005126
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312521(uc003ccs.2 uc010hfd.2 uc011awk.1) ENST00000383773
    ENST00000492552 ENST00000468700 ENST00000472780
    miRNA
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    hsa-miR-323-3p hsa-miR-607 hsa-miR-938 hsa-miR-485-3p hsa-miR-128 hsa-miR-502-3p hsa-miR-3148 hsa-miR-376c
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    Additional mRNA sequence: 

    AB209091.1 AB307693.1 AK293273.1 AK301925.1 AK313464.1 BC015929.1 BC045613.1 BC070035.1 
    BX537786.1 CR457434.1 D16815.1 HQ692830.1 HQ692831.1 L31785.1 

    9 DOTS entries:

    DT.95230991  DT.86837593  DT.411284  DT.100800113  DT.100821773  DT.120902203  DT.120902041  DT.120902284 
    DT.92362616 

    24/170 AceView cDNA sequences (see all 170):

    AA458841 BM460536 AI418049 AI862186 BM682263 CR602304 AW026327 BQ440257 
    BE217729 BX537786 AI952370 AA013256 CA312643 AI288821 AI761621 AA404236 
    CA445598 AI803111 AA374069 BM727617 N41813 CA412377 BQ189049 AL708523 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NR1D2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                -                                             
    SP2:                                -                 -                           
    SP3:                                                                              


    ECgene alternative splicing isoforms for NR1D2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR1D2 expression in normal human tissues (normalized intensities)      NR1D2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGAGAA
    NR1D2 Expression
    About this image


    NR1D2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See NR1D2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR1D2

    SOURCE GeneReport for Unigene cluster: Hs.37288
        SABiosciences Expression via Pathway-Focused PCR Arrays including NR1D2: 
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NR1D2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr1d21 , 5 nuclear receptor subfamily 1, group D, member 21, 5 89.06(n)1
    91.32(a)1
      14 (7.08 cM)5
    3531871  NM_011584.41  NP_035714.31 
     182040545 
    chicken
    (Gallus gallus)
    Aves NR1D21 nuclear receptor subfamily 1, group D, member 2 78.89(n)
    83.2(a)
      396125  NM_205205.1  NP_990536.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR1D26
    --
    --
    75(a)
    46(a)
    1 ↔ 1
    possible ortholog
    GL343357.1(624515-655017)
    2(69871162-69884244)
    zebrafish
    (Danio rerio)
    Actinopterygii reverbb2 rev-erb-beta 75.6(n)   30271  AF342942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip75B6
    Ecdysone-induced protein 75B
    12(a)
    1 → many
    3L(17944053-18057796)


    ENSEMBL Gene Tree for NR1D2 (if available)
    TreeFam Gene Tree for NR1D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR1D2 gene
    RORC2  PPARD2  RORA2  PPARA2  NR1D12  RORB2  PPARG2  
    17 SIMAP similar genes for NR1D2 using alignment to 7 protein entries:     NR1D2_HUMAN (see all proteins):
    NR3C2    HNF4alpha    VDR    HNF4G    ESR1    NR1H2
    NR1D1    PPARG    RARG    NR1I3    RORA    NR1F1
    NR1F2    RORB    NR1F3    RORC    NR5A1

    NR1D2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/902 SNPs in NR1D2 are shown (see all 902)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0473804
    ----see VAR_0473802 L M mis40--------
    rs1156510381,2
    F--23926253(+) AAGGCT/CGTGAG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs41318641,2
    C,F,A,H--23926407(-) TAGAAG/TGTGGG 1 -- us2k121Minor allele frequency- T:0.22NS EA NA WA CSA 2348
    rs130872501,2
    C,F--23926436(+) CAAACT/AGGAAA 1 -- us2k14Minor allele frequency- A:0.38NA WA 8
    rs2013908901,2
    C--23926438(+) AACTG-/GAAA  
            
    GAGTT
    1 -- us2k10--------
    rs48585641,2
    C,F,A,H--23926450(+) TTTTAC/TAAGCA 1 -- us2k116Minor allele frequency- T:0.17NS EA NA WA 2094
    rs1400022081,2
    C--23926487(+) TAACAA/TCTTAC 1 -- us2k10--------
    rs1454125871,2
    --23926503(+) CATCTA/GTTCAT 1 -- us2k10--------
    rs1997560701,2
    --23926512(+) ATGCC-/TCTA  
            
    TCAGC
    1 -- us2k10--------
    rs1138281631,2
    F--23926526(+) CCATCC/TTACTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for NR1D2 (23986751 - 24022109 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NR1D2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834638CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    NR1D2 for disorders           About MalaCards
    OMIM gene information: 602304    OMIM disorders: --


    NR1D2 for disorders           About GeneDecksing


    Export disorders for NR1D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR1D2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NR1D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. (PubMed id 7997240)1, 2, 3 Dumas B.... Moore D.D. (1994)
    2. Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta. (PubMed id 17870090)1, 2 Woo E.-J.... Eon Ryu S. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. (PubMed id 11113208)1, 2 Sauve F....Giguere V. (2001)
    5. Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication. (PubMed id 10198169)1, 3 Koh Y.S. and Moore D.D. (1999)
    6. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. (PubMed id 18037887)1, 9 Raghuram S....Rastinejad F. (2007)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}. (PubMed id 21123168)1 Gupta N. and Ragsdale S.W. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9975 HGNC: 7963 AceView: NR1D2 Ensembl:ENSG00000174738 euGenes: HUgn9975
    ECgene: NR1D2 H-InvDB: NR1D2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR1D2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR1D2 gene:
    Search GeneIP for patents involving NR1D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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