Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR1D1 Gene

protein-coding   GIFtS: 65
GCID: GC17M038249

Nuclear Receptor Subfamily 1, Group D, Member 1


(Previous symbol: THRAL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 1, Group D, Member 11 2     hRev2
THRAL1 2 3 5     Nuclear Receptor Rev-ErbA-Alpha2
EAR12 3 5     Nuclear Receptor Subfamily 1 Group D Member 12
V-ErbA-Related Protein 12 3     rev-erbA-alpha2
Rev-ErbAalpha2     EAR-13
THRA12     HREV3
ear-12     Rev-erbA-alpha3

External Ids:    HGNC: 79621   Entrez Gene: 95722   Ensembl: ENSG000001263687   OMIM: 6024085   UniProtKB: P203933   

Export aliases for NR1D1 gene to outside databases

Previous GC identifers: GC17M037844 GC17P040302 GC17M038159 GC17M038624 GC17M035502 GC17M034042


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR1D1 Gene:
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein
is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In
particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear
translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in
metabolic, inflammatory and cardiovascular processes. (provided by RefSeq, Jan 2013)

GeneCards Summary for NR1D1 Gene: 
NR1D1 (nuclear receptor subfamily 1, group D, member 1) is a protein-coding gene. Diseases associated with NR1D1 include cauda equina syndrome, and bipolar i disorder, and among its related super-pathways are Circadian Clock and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is RORC.

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393
Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1
transcription (By similarity). Possible receptor for triiodothyronine

Gene Wiki entry for NR1D1 (Rev-ErbA alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR1D1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   LCR-F1   YY1   Arnt   Nkx3-1 v2   PPAR-gamma1   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR1D1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR1D1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q11.2

NR1D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1D1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038249:  view genomic region     (about GC identifiers)

Start:
38,249,037 bp from pter      End:
38,256,978 bp from pter
Size:
7,942 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 1 group D member 1  
Size: 614 amino acids; 66805 Da
Subunit: Interacts with C1D and NR2E3 (By similarity). Interacts with SP1 (By similarity)
Subcellular location: Nucleus (Potential)
5 PDB 3D structures from and Proteopedia for NR1D1:
1A6Y (3D)        1EF6 (3D)        1GA5 (3D)        1HLZ (3D)        3N00 (3D)    
Secondary accessions: Q0P5Z4 Q15304

Explore the universe of human proteins at neXtProt for NR1D1: NX_P20393

Explore proteomics data for NR1D1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20393

  • NR1D1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NR1D1 Protein Expression
    REFSEQ proteins: NP_068370.1  
    ENSEMBL proteins: 
     ENSP00000246672  
    Reactome Protein details: P20393
    Human Recombinant Protein Products for NR1D1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NR1D1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NR1D1
    GenScript Custom Purified and Recombinant Proteins Services for NR1D1
    Novus Biologicals NR1D1 Protein
    Novus Biologicals NR1D1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NR1D1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA18511497
    GO:0005634nucleus TAS8622974
    GO:0005654nucleoplasm TAS--

    NR1D1 for ontologies           About GeneDecksing



    NR1D1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NR1D1
    R&D Systems Antibodies for NR1D1 (Rev-erb A alpha/NR1D1)
    Cell Signaling Technology (CST) Antibodies for NR1D1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NR1D1
    GenScript Custom Superior Antibodies Services for NR1D1
    Novus Biologicals NR1D1 Antibodies
    Abcam antibodies for NR1D1
    Cloud-Clone Corp. Antibodies for NR1D1 
    ThermoFisher Antibody for NR1D1
    LSBio Antibodies in human, mouse, rat for NR1D1 

    Assay Products for NR1D1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NR1D1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NR1D1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NR1D1 
    Cloud-Clone Corp. CLIAs for NR1D1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rev-Erb-&alpha 
    1D. Rev-Erb receptors

    5 InterPro protein domains:
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P20393

    ProtoNet protein and cluster: P20393

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR1D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR1D1_HUMAN, P20393
    Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1
    transcription (By similarity). Possible receptor for triiodothyronine

         Genatlas biochemistry entry for NR1D1:
    nuclear receptor subfamily 1,group D,member 1,partially overlapping THRA (exon for THRA2) on the opposite strand

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003714transcription corepressor activity TAS8622974
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS8622974
         
    NR1D1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NR1D1:
     Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nr1d1):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 

    NR1D1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NR1D1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NR1D1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR1D1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR1D1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR1D1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR1D1 (see all 9):
    hsa-miR-1290 hsa-miR-1266 hsa-miR-876-5p hsa-miR-3672 hsa-miR-29b-1* hsa-miR-4267 hsa-miR-3167 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidNR1D1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NR1D1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR1D1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR1D1
    Sirion Biotech Customized adenovirus for overexpression of NR1D1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NR1D1 (see all 7)
    OriGene ORF clones in mouse, rat for NR1D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NR1D1 (NM_021724)
    Sino Biological Human cDNA Clone for NR1D1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR1D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D1
    Sirion Biotech Customized lentivirus for stable overexpression of NR1D1 
                         Customized lentivirus expression plasmids for stable overexpression of NR1D1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NR1D1
    Search LifeMap BioReagents cell lines for NR1D1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NR1D1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression0.40
    Circadian Clock in Mammals0.30
    2Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    3Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    4RORA Activates Circadian Expression
    RORA Activates Circadian Expression
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NR1D1
        Circadian Clock in Mammals

    2 Cell Signaling Technology (CST) Pathways for NR1D1
        Glucose / Energy Metabolism
    NF-kappaB Signaling

    1 BioSystems Pathway for NR1D1
        Circadian rhythm pathway


    5/6        Reactome Pathways for NR1D1 (see all 6)
        Circadian Clock
    Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression
    Gene Expression


    1         Kegg Pathway  (Kegg details for NR1D1):
        Circadian rhythm


    NR1D1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR1D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for NR1D1 (P203933 ENSP000002466724) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR1D2Q149953, ENSP000003100064I2D: score=2 STRING: ENSP00000310006
    NCOR1O753763, ENSP000002687124I2D: score=3 STRING: ENSP00000268712
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    HUWE1Q7Z6Z73, ENSP000002628544I2D: score=1 STRING: ENSP00000262854
    MYCBP2O755923, ENSP000003498924I2D: score=1 STRING: ENSP00000349892
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP18511497
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007623circadian rhythm IEA--
    GO:0010467gene expression TAS--

    NR1D1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR1D1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR1D1

    3 IUPHAR Ligands for NR1D1 (Rev-Erb-&alpha)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SR8278
    Antagonist6.521043485
    GSK4112
    AgonistAgonist6.421043485
    heme
    AgonistAgonist6.418006707 18037887

    1 PharmGKB related drug/compound annotation for NR1D1 gene    About this table
    Drug/compound PharmGKB Annotation
    lithiumCA  

    Search CenterWatch for drugs/clinical trials and news about NR1D1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR1D1 gene: 
    NM_021724.4  

    Unigene Cluster for NR1D1:

    Nuclear receptor subfamily 1, group D, member 1
    Hs.592130  [show with all ESTs]
    Unigene Representative Sequence: NM_021724
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246672(uc002htz.2 uc010cwq.2 uc010cwr.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR1D1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR1D1 (see all 9):
    hsa-miR-1290 hsa-miR-1266 hsa-miR-876-5p hsa-miR-3672 hsa-miR-29b-1* hsa-miR-4267 hsa-miR-3167 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidNR1D1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NR1D1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR1D1
    Clone
    Products:
         
    OriGene clones in human, mouse for NR1D1 (see all 7)
    OriGene ORF clones in mouse, rat for NR1D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NR1D1 (NM_021724)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR1D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D1
    Sirion Biotech Customized lentivirus for stable overexpression of NR1D1 
                         Customized lentivirus expression plasmids for stable overexpression of NR1D1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NR1D1
    OriGene qSTAR qPCR primer pairs in human, mouse for NR1D1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR1D1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1D1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1D1

    Additional mRNA sequence: 

    AK300155.1 AK315270.1 AY429554.1 BC047875.1 BC056148.1 HQ692861.1 M24898.1 X72631.1 

    14 DOTS entries:

    DT.99939115  DT.87015529  DT.118299  DT.95103779  DT.100031090  DT.118297  DT.97847061  DT.75124373 
    DT.100807968  DT.120980021  DT.120980162  DT.102833248  DT.120980143  DT.99953623 

    24/146 AceView cDNA sequences (see all 146):

    BM671861 BC056148 BQ899181 BM709734 CR598991 CA425802 CN479067 M34340 
    BX090148 BQ687824 BU150289 CR608219 AL118889 BG747927 R84761 BU956398 
    BQ652234 BM710421 BQ688463 BC047875 BQ880520 BQ927499 BM662383 AA453202 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NR1D1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                              
    SP2:                                                  -                           
    SP3:                                                                              
    SP4:                                                  -     -     -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for NR1D1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR1D1 expression in normal human tissues (normalized intensities)      NR1D1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTCCGAGA
    NR1D1 Expression
    About this image


    NR1D1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Eye (Sensory Organs)
             Rod Precursor Cells Outer Nuclear Layer

    See NR1D1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR1D1

    SOURCE GeneReport for Unigene cluster: Hs.592130

    UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393
    Tissue specificity: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous
    carcinoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR1D1: 
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NR1D1
    OriGene qSTAR qPCR primer pairs in human, mouse for NR1D1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR1D1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1D1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1D1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NR1D1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr1d11 , 5 nuclear receptor subfamily 1, group D, member 11, 5 90.12(n)1
    95.77(a)1
      11 (62.66 cM)5
    2171661  NM_145434.31  NP_663409.21 
     987679325 
    lizard
    (Anolis carolinensis)
    Reptilia NR1D16
    --
    --
    69(a)
    47(a)
    1 ↔ 1
    possible ortholog
    6(69322211-69338166)
    2(69871162-69884244)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97782 Xenopus laevis transcribed sequence with moderate similarity more 78.9(n)    BX847857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271242 Danio rerio nuclear receptor subfamily 1, group D, more 78.2(n)    AY391444.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip78C3 larval/pupal development (sensu
    Insecta) ligand-dependent more
    71(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for NR1D1 (if available)
    TreeFam Gene Tree for NR1D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR1D1 gene
    RORC2  NR1D22  PPARD2  RORA2  PPARA2  RORB2  PPARG2  
    2 SIMAP similar genes for NR1D1 using alignment to 2 protein entries:     NR1D1_HUMAN (see all proteins):
    NR1D2    RORA

    NR1D1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NR1D1
    PGOHUM00000240883


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in NR1D1 are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008978671,2
    C--34049004(+) GGGGGA/GGGGGG 1 -- int10--------
    rs1889920921,2
    --38250732(+) AAGCAA/GCAGGA 1 -- int10--------
    rs1920544401,2
    --38250750(+) AGCCCC/TTTTCA 1 -- int10--------
    rs1834437041,2
    --38250765(+) TCAGGC/TTATAA 1 -- int10--------
    rs777981901,2
    C,F--38250766(+) CAGGCT/AATAAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs47948261,2
    C,F,H--38250782(-) ACCCAG/ATATCT 1 -- int112Minor allele frequency- A:0.05NS EA NA 1466
    rs1866328841,2
    --38250971(+) CATGGC/TGAAAC 1 -- int10--------
    rs1409236491,2
    C,F--38251177(+) ATAAAC/TGGTCA 1 -- int11Minor allele frequency- T:0.02EU 1311
    rs1997107601,2
    C--38251248(+) AAGCCC/TGGGAT 2 P syn10--------
    rs1424017471,2
    C,F--38251287(+) ACAGCG/AGGCGT 2 /P syn12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for NR1D1 (38249037 - 38256978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NR1D1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908221CNV Loss21882294
    nsv520636CNV Loss19592680
    nsv528369CNV Loss19592680
    nsv833444CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NR1D1
    DNA2.0 Custom Variant and Variant Library Synthesis for NR1D1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602408    OMIM disorders: --

    11 diseases for NR1D1:    About MalaCards
    cauda equina syndrome    bipolar i disorder    sleep disorder    schizoaffective disorder
    major depressive disorder    mood disorder    bipolar disorder    osteoarthritis
    schizophrenia    thyroiditis    breast cancer


    NR1D1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NR1D1
    Human Genome Epidemiology (HuGE) Navigator: NR1D1 (15 documents)

    Export disorders for NR1D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR1D1 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with NR1D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. (PubMed id 1971514)1, 2, 3 Lazar M.A.... Chin W.W. (1990)
    2. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. (PubMed id 18804497)1, 4, 9 Kishi T....Iwata N. (2008)
    3. Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. (PubMed id 19267705)1, 4, 9 Severino G....Del Zompo M. (2009)
    4. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (2010)
    5. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (2010)
    6. Nuclear receptor rev-erb-{alpha} circadian gene varia nts and lithium carbonate prophylaxis in bipolar affective disorder. (PubMed id 20348464)1, 4 Campos-de-Sousa S....Collier D. (2010)
    7. PER2 variantion is associated with depression vulnera bility. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorp hisms in 199 Sardinian bipolar patients. (PubMed id 19818381)1, 4 Manchia M....Del Zompo M. (2009)
    10. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9572 HGNC: 7962 AceView: NR1D1 Ensembl:ENSG00000126368 euGenes: HUgn9572
    ECgene: NR1D1 Kegg: 9572 H-InvDB: NR1D1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR1D1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR1D1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR1D1 gene:
    Search GeneIP for patents involving NR1D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NR1D1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NR1D1 (Rev-erb A alpha/NR1D1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NR1D1  
     OriGene qPCR primer pairs and template standards for NR1D1   OriGene Protein Over-expression Lysate for NR1D1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NR1D1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NR1D1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NR1D1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NR1D1   OriGene Custom Protein Services for NR1D1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR1D1
     QIAGEN SeqTarget long-range PCR primers for resequencing NR1D1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1D1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR1D1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1D1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1D1
     GenScript Custom Purified and Recombinant Proteins Services for NR1D1 GenScript cDNA clones with any tag delivered in your preferred vector for NR1D1
     GenScript Custom Assay Services for NR1D1 GenScript Custom Superior Antibodies Services for NR1D1
     GenScript Custom overexpressing Cell Line Services for NR1D1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NR1D1 

     Regulatory tfbs in NR1D1 promoter
     Search Chromatin IP Primers for NR1D1
     RT2 qPCR Primer Assay in human, mouse, rat NR1D1
     GNC Network for NR1D1
     SABiosciences PCR Arrays including human, mouse, rat NR1D1
     Search Tocris compounds for NR1D1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NR1D1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NR1D1 antibodies
     NR1D1 proteins
     NR1D1 lysates
     Antibodies for NR1D1
     See all of Abcam's Antibodies, Kits and Proteins for NR1D1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NR1D1
     Antibodies for NR1D1
     ELISAs for NR1D1
     CLIAs for NR1D1
     Search LifeMap BioReagents cell lines for NR1D1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D1
     SwitchGear 3'UTR luciferase reporter plasmids for NR1D1
     SwitchGear Promoter luciferase reporter plasmids for NR1D1
     ThermoFisher Antibody for NR1D1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR1D1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NR1D1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NR1D1
    Customized:
     lentivirus for stable overexpression of NR1D1
     lentivirus expression plasmids for stable overexpression of NR1D1
     adenovirus for overexpression of NR1D1
     LSBio Antibodies in human, mouse, rat for NR1D1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NR1D1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4