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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NR1D1 Gene

protein-coding GIFtS: 63
GCID: GC17M038249

nuclear receptor subfamily 1, group D, member 1

(Previous symbol: THRAL)

Explore 15 diseases affiliated with
NR1D1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 1, Group D, Member 1¹ ²		V-ErbA-Related Protein 1² ³
THRAL¹ ² ³ ⁵		Nuclear Receptor Rev-ErbA-Alpha²
EAR1² ³ ⁵		Nuclear Receptor Subfamily 1 Group D Member 1²
Rev-ErbAalpha¹ ²		Rev-ErbA-Alpha¹
THRA1¹ ²		EAR-1³
Ear-1¹		HREV³
HRev¹		Rev-ErbA-Alpha¹

External Ids:	HGNC: 7962¹	Entrez Gene: 9572²	Ensembl: ENSG00000126368⁷	OMIM: 602408⁵	UniProtKB: P20393³

Export aliases for NR1D1 gene to outside databases

Previous GC identifers: GC17M037844 GC17P040302 GC17M038159 GC17M038624 GC17M035502 GC17M034042

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR1D1:

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a

ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular

this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like

protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and

cardiovascular processes. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393

Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1

transcription (By similarity). Possible receptor for triiodothyronine

Gene Wiki entry for NR1D1 (Rev-ErbA alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NR1D1 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 LCR-F1 YY1 Arnt Nkx3-1 v2 PPAR-gamma1 Ik-2 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NR1D1 promoter sequence

Search SABiosciences Chromatin IP Primers for NR1D1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR1D1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q11.2

NR1D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR1D1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M038249: view genomic region (about GC identifiers)

Start:	38,249,037 bp from pter	End:	38,256,978 bp from pter
Size:	7,942 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393 (See protein sequence)

Recommended Name: Nuclear receptor subfamily 1 group D member 1

Size: 614 amino acids; 66805 Da

Subunit: Interacts with C1D and NR2E3 (By similarity). Interacts with SP1 (By similarity)

Subcellular location: Nucleus (Potential)

5 PDB 3D structures from and Proteopedia for NR1D1:

1A6Y (3D)

1EF6 (3D)

1GA5 (3D)

1HLZ (3D)

3N00 (3D)

Secondary accessions: Q0P5Z4 Q15304

Explore the universe of human proteins at neXtProt for NR1D1: NX_P20393

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20393

NR1D1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_068370.1

ENSEMBL proteins:

ENSP00000246672

Reactome Protein details: P20393
Human Recombinant Protein Products:

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	Uscn Proteins for NR1D1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IDA	18511497
GO:0005634	nucleus	TAS	8622974
GO:0005654	nucleoplasm	TAS	--

NR1D1 for ontologies About GeneDecksing

NR1D1 Antibody Products:

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Assay Products for NR1D1:

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	GenScript Custom Assay Services for NR1D1
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	Uscn ELISAs and CLIAs for NR1D1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NR1D1 for domains About GeneDecksing

5 InterPro domains/families:

IPR013088 Znf_NHR/GATA

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

IPR001628 Znf_hrmn_rcpt

IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry P20393

ProtoNet protein and cluster: P20393

2 Blocks protein families:

IPB000324 Vitamin D receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding

domain

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393

Function: Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1

transcription (By similarity). Possible receptor for triiodothyronine

Genatlas biochemistry entry for NR1D1:

nuclear receptor subfamily 1,group D,member 1,partially overlapping THRA (exon for THRA2) on the opposite strand

miRNA Products:		OriGene 3'-UTR Clone: NR1D1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR1D1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR1D1 (see all 9):
		hsa-miR-1290 hsa-miR-1266 hsa-miR-876-5p hsa-miR-3672 hsa-miR-29b-1* hsa-miR-4267 hsa-miR-3167 hsa-miR-338-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NR1D1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR1D1 (see all 7) OriGene shRNA RFP: NR1D1 OriGene siRNA: NR1D1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NR1D1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NR1D1
		Search LifeMap BioReagents cell lines for NR1D1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0003714	transcription corepressor activity	TAS	8622974
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	TAS	8622974

NR1D1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NR1D1:

Upregulation of Wnt/beta-caten

Animal Models:
10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Nr1d1):

behavior/neurological	cellular	growth/size	homeostasis/metabolism	liver/biliary system
mortality/aging	muscle	nervous system	no phenotypic analysis	reproductive system

NR1D1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Circadian rhythm - mammal

	Circadian rhythm - mammal	1.00			Circadian Clock in Mammals	0.40
	Circadian Clock	0.41			BMAL1:CLOCK/NPAS2 Activates Circadian Expression	0.23

Expression of NR1D1 (REV-ERBA)

Expression of NR1D1 (REV-ERBA)

1.00

NR1D1 (REV-ERBA) Binds Heme and Corepressors

0.33

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NR1D1

Circadian Clock in Mammals

2 Cell Signaling Technology (CST) Pathways for NR1D1

	Glucose / Energy Metabolism
	NF-kappaB Signaling

1 BioSystems Pathway for NR1D1

Circadian rhythm pathway

5/8 Reactome Pathways for NR1D1 (see all 8)

	Circadian Clock
	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	NR1D1 (REV-ERBA) Binds Heme and Corepressors
	BMAL1:CLOCK/NPAS2 Activates Circadian Expression

1 Kegg Pathway (Kegg details for NR1D1):

Circadian rhythm - mammal

NR1D1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NR1D1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for NR1D1 (P20393³ ENSP00000246672⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR1D2	Q14995³, ENSP00000310006⁴	I2D: score=2 STRING: ENSP00000310006
NCOR1	O75376³, ENSP00000268712⁴	I2D: score=3 STRING: ENSP00000268712
HDAC3	O15379³, ENSP00000302967⁴	I2D: score=1 STRING: ENSP00000302967
HUWE1	Q7Z6Z7³, ENSP00000262854⁴	I2D: score=1 STRING: ENSP00000262854
MYCBP2	O75592³, ENSP00000349892⁴	I2D: score=1 STRING: ENSP00000349892

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	18511497
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0007623	circadian rhythm	IEA	--
GO:0010467	gene expression	TAS	--

NR1D1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NR1D1
Search CenterWatch for drugs/clinical trials and news about NR1D1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NR1D1 gene:

NM_021724.4

Unigene Cluster for NR1D1:

Nuclear receptor subfamily 1, group D, member 1

Hs.592130 [show with all ESTs]

Unigene Representative Sequence: NM_021724

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000246672(uc002htz.2 uc010cwq.2 uc010cwr.1)

miRNA Products:		OriGene 3'-UTR Clone: NR1D1 Browse OriGene MicroRNA Expression Plasmids
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		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR1D1 (see all 9):
		hsa-miR-1290 hsa-miR-1266 hsa-miR-876-5p hsa-miR-3672 hsa-miR-29b-1* hsa-miR-4267 hsa-miR-3167 hsa-miR-338-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NR1D1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: NR1D1 (NM_021724)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1D1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1D1

Additional cDNA sequence:

AK300155.1 AK315270.1 AY429554.1 BC047875.1 BC056148.1 HQ692861.1 M24898.1 X72631.1

13 DOTS entries:

DT.99939115 DT.87015529 DT.118299 DT.95103779 DT.100031090 DT.118297 DT.75124373 DT.97847061

DT.100807968 DT.120980021 DT.120980162 DT.102833248 DT.120980143

24/146 AceView cDNA sequences (see all 146):

M34340 BQ917541 BQ899181 BQ927499 BC056148 CR608219 AL118889 BM709734

BU956398 BM662383 BX090148 BU956435 BQ688463 CN479067 BU150289 BM671861

CR598991 BQ652234 BC047875 BQ687824 BQ181923 BQ002038 AA453202 BM710421

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NR1D1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9
SP1:
SP2:																	-
SP3:
SP4:																	-		-		-
SP5:

ECgene alternative splicing isoforms for NR1D1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NR1D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTCCGAGA

About this image

NR1D1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Rod Precursor Cells

Photoreceptors, Retina

Ovary

Antral Follicle

Mature Granulosa Cells

Ovary

Brain

Hypothalamus

Brain

Thalamus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NR1D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR1D1

SOURCE GeneReport for Unigene cluster: Hs.592130

UniProtKB/Swiss-Prot: NR1D1_HUMAN, P20393

Tissue specificity: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous

carcinoma cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including NR1D1:

Circadian Rhythms in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR1D1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR1D1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR1D1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NR1D1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	NR1D1⁶	--	70(a)	1 ↔ 1	6(69322211-69328570)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9778²	Xenopus laevis transcribed sequence with moderate similarity more	78.9(n)		BX847857.1
zebrafish (Danio rerio)	Actinopterygii	Dr.27124²	Danio rerio nuclear receptor subfamily 1, group D, more	78.2(n)		AY391444.1
fruit fly (Drosophila melanogaster)	Insecta	Eip78C³	larval/pupal development (sensu Insecta) ligand-dependent more	71(a) (best of 2)		--

ENSEMBL Gene Tree for NR1D1 (if available)
TreeFam Gene Tree for NR1D1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NR1D1 gene

RORC² NR1D2² PPARD² RORA² PPARA² RORB² PPARG²

2 SIMAP similar genes for NR1D1 using alignment to 2 protein entries: NR1D1_HUMAN (see all proteins):

NR1D2 RORA

NR1D1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NR1D1
PGOHUM00000240883

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188992092^1,2		--	38250732(+)	`AAGCAA/GCAGGA`	1	--	int¹		0	--	--	--	--
rs192054440^1,2		--	38250750(+)	`AGCCCC/TTTTCA`	1	--	int¹		0	--	--	--	--
rs183443704^1,2		--	38250765(+)	`TCAGGC/TTATAA`	1	--	int¹		0	--	--	--	--
rs77798190^1,2	F,	--	38250766(+)	`CAGGCT/AATAAG`	1	--	int¹		1		WA	118
rs4794826^1,2	C,F,H,	--	38250782(-)	`ACCCAG/ATATCT`	1	--	int¹		12		NS EA NA	1466
rs186632884^1,2		--	38250971(+)	`CATGGC/TGAAAC`	1	--	int¹		0	--	--	--	--
rs140923649^1,2	C,F,	--	38251177(+)	`ATAAAC/TGGTCA`	1	--	int¹		1		EU	1311
rs142401747^1,2	C,F	--	38251287(+)	`ACAGCG/AGGCGT`	2	/P	syn¹		2		NA EU	5873
rs147940256^1,2	C	--	38251329(+)	`TGCACC/TGTTCG`	2	T	syn¹		1		NA	4550
rs140172310^1,2	C,	--	38251358(+)	`GTACAT/CGTTCA`	2	/M /V	mis¹		1		NA	4546

HapMap Linkage Disequilibrium report for NR1D1 (38249037 - 38256978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NR1D1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NR1D1 for disorders           About GeneDecksing

OMIM gene information: 602408    OMIM disorders: --

15 diseases for NR1D1:    About MalaCards

cauda equina syndrome major depressive disorder bipolar affective disorder bipolar i disorder

schizoaffective disorder mood disorder sleep disorder bipolar disorder

osteoarthritis breast cancer cholesterol schizophrenia

thyroiditis carcinoma septic shock

Human Genome Epidemiology (HuGE) Navigator: NR1D1 (15 documents)

Export disorders for NR1D1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NR1D1 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with NR1D1)

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Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. (PubMed id 1971514)^{1, 2, 3} Lazar M.A.... Chin W.W. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural elements of an orphan nuclear receptor-DNA complex. (PubMed id 9660968)^{1, 2} Zhao Q.... Rastinejad F. (1998)
Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (PubMed id 1850510)^{1, 2} Laudet V....Saule S. (1991)
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. (PubMed id 2539258)^{1, 2} Miyajima N.... Yamamoto T. (1989)
Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. (PubMed id 18804497)^{1, 9} Kishi T....Iwata N. (2008)
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. (PubMed id 15190009)^{1, 9} Cheng H....Swaroop A. (2004)
Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. (PubMed id 19267705)^{1, 9} Severino G....Del Zompo M. (2009)
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. (PubMed id 18037887)^{1, 9} Raghuram S....Rastinejad F. (2007)
Expression of retinoic acid-related orphan receptor a lpha and its responsive genes in human endometrium regulated by cholesterol sul fate. (PubMed id 22024429)¹ Zenri F....Taketani Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9572	HGNC: 7962	AceView: NR1D1	Ensembl:ENSG00000126368	euGenes: HUgn9572
ECgene: NR1D1	Kegg: 9572	H-InvDB: NR1D1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NR1D1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NR1D1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NR1D1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NR1D1 gene:
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GeneCards and IP:
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nuclear receptor subfamily 1, group D, member 1

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nuclear receptor subfamily 1, group D, member 1

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