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Aliases for NR1D1 Gene

Aliases for NR1D1 Gene

  • Nuclear Receptor Subfamily 1 Group D Member 1 2 3 5
  • V-ErbA-Related Protein 1 3 4
  • Rev-ErbA-Alpha 3 4
  • Ear-1 3 4
  • THRAL 3 4
  • HRev 3 4
  • EAR1 3 4
  • Nuclear Receptor Subfamily 1, Group D, Member 1 2
  • Nuclear Receptor Rev-ErbA-Alpha 3
  • Rev-ErbAalpha 3
  • THRA1 3

External Ids for NR1D1 Gene

Previous HGNC Symbols for NR1D1 Gene

  • THRAL

Previous GeneCards Identifiers for NR1D1 Gene

  • GC17M037844
  • GC17P040302
  • GC17M038159
  • GC17M038624
  • GC17M035502
  • GC17M038249
  • GC17M034042

Summaries for NR1D1 Gene

Entrez Gene Summary for NR1D1 Gene

  • This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

GeneCards Summary for NR1D1 Gene

NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) is a Protein Coding gene. Diseases associated with NR1D1 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment. Among its related pathways are Circadian rhythm and BMAL1-CLOCK,NPAS2 activates circadian gene expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NR1D2.

UniProtKB/Swiss-Prot for NR1D1 Gene

  • Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5-[A/G]GGTCA-3 preceded by an A/T-rich 5 sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.

Tocris Summary for NR1D1 Gene

  • Rev-Erb receptors are orphan nuclear receptors belonging to the NR1D receptor family. There are two types, Rev-Erbalpha and Rev-Erbbeta. They are important in the regulation of circadian rhythm, as well as lipid homeostasis and lipid metabolism.

Gene Wiki entry for NR1D1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR1D1 Gene

Genomics for NR1D1 Gene

Regulatory Elements for NR1D1 Gene

Enhancers for NR1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040061 1.8 VISTA FANTOM5 Ensembl ENCODE 3.1 +31.4 31430 14.8 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 MED24 GSDMA MSL1 SNORD124 RAPGEFL1 PSMD3 TMEM99 MED1 TCAP ORMDL3
GH17F040088 1.2 FANTOM5 Ensembl ENCODE 2.1 +5.4 5378 14.4 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 MSL1 CDK12 IGFBP4 MED1 ENSG00000266469 MED24 GSDMA MIR6884 THRA ERBB2
GH17F040102 1.5 FANTOM5 ENCODE 2 -8.7 -8742 13.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 MSL1 ENSG00000266469 MED1 CDK12 CASC3 MIR6866 THRA MED24 MIR6884 CDC6
GH17F040217 1.2 FANTOM5 ENCODE 1.5 -118.4 -118396 2.8 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MED1 ENSG00000266469 IGFBP4 CDK12 RAPGEFL1 LOC105371776 PGAP3 ERBB2 RPL23AP75 ENSG00000266208
GH17F040086 0.5 ENCODE 0.4 +14.1 14113 0.2 CTCF ARID4B THRB ZNF48 RAD21 PATZ1 ZNF143 SMC3 THAP11 GATAD2A MED24 MIR6884 THRA MSL1 PSMD3 GSDMA LRRC3C ORMDL3 CDC6 GC17P040082
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NR1D1 on UCSC Golden Path with GeneCards custom track

Promoters for NR1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345883 625 2201 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548

Genomic Location for NR1D1 Gene

Chromosome:
17
Start:
40,092,784 bp from pter
End:
40,100,725 bp from pter
Size:
7,942 bases
Orientation:
Minus strand

Genomic View for NR1D1 Gene

Genes around NR1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR1D1 Gene

Proteins for NR1D1 Gene

  • Protein details for NR1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20393-NR1D1_HUMAN
    Recommended name:
    Nuclear receptor subfamily 1 group D member 1
    Protein Accession:
    P20393
    Secondary Accessions:
    • Q0P5Z4
    • Q15304

    Protein attributes for NR1D1 Gene

    Size:
    614 amino acids
    Molecular mass:
    66805 Da
    Quaternary structure:
    • Binds DNA as a monomer or a homodimer. Interacts with C1D, NR2E3 and SP1. Interacts with OPHN1 (via C-terminus). Interacts with ZNHIT1. Interacts with PER2; the interaction associates PER2 to ARNTL promoter region. Interacts with CRY1. Interacts with CCAR2.

    Three dimensional structures from OCA and Proteopedia for NR1D1 Gene

neXtProt entry for NR1D1 Gene

Post-translational modifications for NR1D1 Gene

Other Protein References for NR1D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NR1D1 (Rev-erb A alpha/NR1D1)
  • Cell Signaling Technology (CST) Antibodies for NR1D1 (NR1D1)

No data available for DME Specific Peptides for NR1D1 Gene

Domains & Families for NR1D1 Gene

Gene Families for NR1D1 Gene

Suggested Antigen Peptide Sequences for NR1D1 Gene

Graphical View of Domain Structure for InterPro Entry

P20393

UniProtKB/Swiss-Prot:

NR1D1_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with NR1D1: view

Function for NR1D1 Gene

Molecular function for NR1D1 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 1,group D,member 1,partially overlapping THRA (exon for THRA2) on the opposite strand
UniProtKB/Swiss-Prot Function:
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5-[A/G]GGTCA-3 preceded by an A/T-rich 5 sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.

Gene Ontology (GO) - Molecular Function for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 19955433
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 8622974
GO:0001046 core promoter sequence-specific DNA binding IEA,IDA 15761026
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8622974
GO:0001222 transcription corepressor binding IMP 18006707
genes like me logo Genes that share ontologies with NR1D1: view
genes like me logo Genes that share phenotypes with NR1D1: view

Animal Models for NR1D1 Gene

MGI Knock Outs for NR1D1:

Animal Model Products

miRNA for NR1D1 Gene

miRTarBase miRNAs that target NR1D1
Targeted motifs for NR1D1 Gene
HOMER Transcription Factor Regulatory Elements motif NR1D1
  • Consensus sequence: GTAGGTCACTGGGTCA Submotif: DR2 Cell Type: RAW GEO ID: GSE45914

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NR1D1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NR1D1 Gene

Localization for NR1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR1D1 Gene

Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Note=Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR1D1 Gene COMPARTMENTS Subcellular localization image for NR1D1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 18511497
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with NR1D1: view

Pathways & Interactions for NR1D1 Gene

genes like me logo Genes that share pathways with NR1D1: view

Pathways by source for NR1D1 Gene

1 KEGG pathway for NR1D1 Gene
1 Qiagen pathway for NR1D1 Gene

SIGNOR curated interactions for NR1D1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NR1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18511497
GO:0005978 glycogen biosynthetic process IEA,ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR1D1: view

Drugs & Compounds for NR1D1 Gene

(6) Drugs for NR1D1 Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 0
GSK 4112 Pharma antagonist of the Nuclear Heme Receptor REV-ERB, Selective Rev-Erbalpha agonist 0
SR 8278 Pharma Rev-Erbalpha antagonist 0
GSK4112 Pharma Agonist 0
heme Pharma Agonist 0

(1) Additional Compounds for NR1D1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 9009
1379686-30-2

(3) Tocris Compounds for NR1D1 Gene

Compound Action Cas Number
GSK 4112 Selective Rev-Erbalpha agonist 1216744-19-2
SR 8278 Rev-Erbalpha antagonist 1254944-66-5
SR 9009 Rev-Erbalpha/beta agonist 1379686-30-2

(2) ApexBio Compounds for NR1D1 Gene

Compound Action Cas Number
GSK 4112 antagonist of the Nuclear Heme Receptor REV-ERB 1216744-19-2
SR 8278 1254944-66-5
genes like me logo Genes that share compounds with NR1D1: view

Transcripts for NR1D1 Gene

mRNA/cDNA for NR1D1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(146) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NR1D1 Gene

Nuclear receptor subfamily 1, group D, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NR1D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR1D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3:
SP4: - - -
SP5:
SP6:

Relevant External Links for NR1D1 Gene

GeneLoc Exon Structure for
NR1D1
ECgene alternative splicing isoforms for
NR1D1

Expression for NR1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NR1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR1D1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x6.1).

Protein differential expression in normal tissues from HIPED for NR1D1 Gene

This gene is overexpressed in Heart (49.6), Urine (9.7), and Stomach (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR1D1 Gene



Protein tissue co-expression partners for NR1D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR1D1 Gene:

NR1D1

SOURCE GeneReport for Unigene cluster for NR1D1 Gene:

Hs.592130

mRNA Expression by UniProt/SwissProt for NR1D1 Gene:

P20393-NR1D1_HUMAN
Tissue specificity: Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines.
genes like me logo Genes that share expression patterns with NR1D1: view

Primer Products

Orthologs for NR1D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR1D1 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia NR1D1 34 35
  • 92.59 (n)
dog
(Canis familiaris)
Mammalia NR1D1 34 35
  • 91.72 (n)
rat
(Rattus norvegicus)
Mammalia Nr1d1 34
  • 90.07 (n)
mouse
(Mus musculus)
Mammalia Nr1d1 34 16 35
  • 90.01 (n)
oppossum
(Monodelphis domestica)
Mammalia NR1D1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NR1D1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr1d1 34
  • 69.79 (n)
Str.16697 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9778 34
zebrafish
(Danio rerio)
Actinopterygii nr1d1 34 35
  • 62.27 (n)
Dr.27124 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8023 34
fruit fly
(Drosophila melanogaster)
Insecta Eip78C 36
  • 71 (a)
Eip75B 36 35
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-85 35
  • 24 (a)
ManyToMany
sex-1 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for NR1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR1D1 Gene

ENSEMBL:
Gene Tree for NR1D1 (if available)
TreeFam:
Gene Tree for NR1D1 (if available)

Paralogs for NR1D1 Gene

Paralogs for NR1D1 Gene

(2) SIMAP similar genes for NR1D1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NR1D1 Gene

genes like me logo Genes that share paralogs with NR1D1: view

Variants for NR1D1 Gene

Sequence variations from dbSNP and Humsavar for NR1D1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10451256 -- 40,098,045(+) AGGTG(C/G)GAGTT intron-variant
rs10512481 -- 40,101,993(+) ATTTC(A/C/G)CTTCA upstream-variant-2KB
rs111528839 -- 40,097,200(+) GGAGC(C/T)GTCAT reference, missense
rs112194173 -- 40,094,848(+) AGTGG(A/C)GATCG intron-variant
rs112753673 -- 40,095,751(+) CATTG(A/G)AGTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NR1D1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv520636 CNV loss 19592680
nsv528369 CNV loss 19592680
nsv833444 CNV loss 17160897

Variation tolerance for NR1D1 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR1D1 Gene

Disorders for NR1D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NR1D1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NR1D1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NR1D1

Genetic Association Database (GAD)
NR1D1
Human Genome Epidemiology (HuGE) Navigator
NR1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR1D1
genes like me logo Genes that share disorders with NR1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR1D1 Gene

Publications for NR1D1 Gene

  1. Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. (PMID: 19267705) Severino G. … Del Zompo M. (Bipolar Disord 2009) 3 22 46 64
  2. Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population. (PMID: 18804497) Kishi T. … Iwata N. (Neurosci. Res. 2008) 3 22 46 64
  3. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. (PMID: 1971514) Lazar M.A. … Chin W.W. (DNA Cell Biol. 1990) 2 3 4 64
  4. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbI+. (PMID: 23398316) Chini C.C. … Chini E.N. (Biochem. J. 2013) 3 4 64
  5. Direct regulation of CLOCK expression by REV-ERB. (PMID: 21479263) Crumbley C. … Burris T.P. (PLoS ONE 2011) 3 4 64

Products for NR1D1 Gene

Sources for NR1D1 Gene

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