Aliases for NR0B2 Gene
External Ids for NR0B2 Gene
Previous GeneCards Identifiers for NR0B2 Gene
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
GeneCards Summary for NR0B2 Gene
NR0B2 (Nuclear Receptor Subfamily 0 Group B Member 2) is a Protein Coding gene. Diseases associated with NR0B2 include Obesity and Hemopneumothorax. Among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Androgen receptor signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NR0B1.
UniProtKB/Swiss-Prot for NR0B2 Gene
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.