NR0B2 Gene
protein-coding GIFtS: 65
GCID: GC01M027237
|
|
nuclear receptor subfamily 0, group B, member 2
| |
Aliases
for NR0B2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Subfamily 0, Group B, Member 21 2 | | SHP12 | | SHP1 2 3 5 | | Nuclear Receptor SHP2 | | Orphan Nuclear Receptor SHP2 3 | | Nuclear Receptor Subfamily 0 Group B Member 22 | | Small Heterodimer Partner2 3 | | |
Export aliases for NR0B2 gene to outside databasesPrevious GC identifers: GC01P028351 GC01M026270 GC01M026471 GC01M026842 GC01M026922 GC01M027110 GC01M025491 |
Summaries
for NR0B2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NR0B2:
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacksa conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group oftranscription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and arereferred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormonereceptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogenreceptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclearhormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effectsof its transcriptional repressor function. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466Function: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways.Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptionalactivity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of thep300/CBP-mediated trancription complex for NEUROD1
Gene Wiki entry for NR0B2 (Small heterodimer partner)
|
Genomic Views
for NR0B2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR0B2 gene promoter:
AhR Lmo2 Arnt C/EBPalpha CHOP-10 PPAR-gamma1 STAT3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR0B2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR0B2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.1 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.1NR0B2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M027237: view genomic region
(about GC identifiers)
Start:
|
27,237,975 bp from pter |
End:
|
27,240,567 bp from pter |
Size:
|
2,593 bases |
Orientation:
|
minus strand |
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Proteins
for NR0B2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466 (See
protein sequence)Recommended Name: Nuclear receptor subfamily 0 group B member 2 Size: 257 amino acids; 28058 Da
Subunit: Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (Bysimilarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (viaN-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2
Subcellular location: Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus
4 PDB 3D structures from  and Proteopedia  for NR0B2:1YUC (3D)
2Q3Y (3D)
2Z4J (3D)
4DOR (3D)
Secondary accessions: Q5QP36Explore the universe of human proteins at neXtProt for NR0B2: NX_Q15466
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15466
NR0B2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068804.1
ENSEMBL proteins: ENSP00000254227 Reactome Protein details: Q15466
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NR0B2 for ontologies About GeneDecksing
NR0B2 Antibody Products:
Assay Products for NR0B2: |
Protein
Domains /
Families
for NR0B2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR0B2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15466ProtoNet protein and cluster: Q15466 UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466Similarity: Belongs to the nuclear hormone receptor family. NR0 subfamily |
Function
for NR0B2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466Function: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways.Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptionalactivity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of thep300/CBP-mediated trancription complex for NEUROD1 Genatlas biochemistry entry for NR0B2:orphan nuclear (steroid/thyroid/retinoid) receptor,subfamily 0,group B,member 2,orphan specifically expressed in fetalliver and adrenal gland,adult spleen and small intestine,heterodimerizing with many members of receptor superfamilyincluding RARs,RRXs,small heterodimer partner interacting with PPARx,potential negative regulator of receptordependent signaling pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NR0B2 (NM_021969) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR0B2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR0B2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR0B2 |
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
NR0B2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for NR0B2:
Animal Models:
Mouse knock-outs for NR0B2: Nr0b2tm1Rus Nr0b2tm1.1Mjev Nr0b2tm1.1Auw
7 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Nr0b2):
NR0B2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NR0B2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Development_Ligand-independent activation of ESR1 and ESR2 | | | 3 | Nuclear Receptor transcription pathway | | | 4 | Androgen receptor signaling pathway | | | 5 | Bile secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NR0B2
1  GeneGo (Thomson Reuters) Pathway for NR0B2
1  BioSystems Pathway for NR0B2
3 
Reactome Pathways for NR0B2
1 
Kegg Pathway (Kegg details for NR0B2):
NR0B2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR0B2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/88 Interacting proteins for NR0B2 (Q154661, 2, 3 ENSP000002542274) via UniProtKB, MINT, STRING, and/or I2D (see all 88)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0008203 | cholesterol metabolic process |
TAS | 11030331 | | GO:0009749 | response to glucose stimulus |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
NR0B2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR0B2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NR0B2 for compounds About GeneDecksing
 Browse Tocris compounds for NR0B2
10/13 Novoseek chemical compound relationships for NR0B2 gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gw 4064 |
75.6 |
3 |
15817812 (2), 16946559 (1) |
| chenodeoxycholic acid |
69.9 |
2 |
15817812 (1), 11518759 (1) |
| phosphoenolpyruvate |
61.5 |
3 |
12324453 (1), 18505831 (1) |
| androstane |
51.8 |
1 |
15858847 (1) |
| tyrosine |
46 |
19 |
10228003 (3), 18233962 (2), 10540344 (1), 10399074 (1) (see all 13) |
| rifampicin |
24.9 |
5 |
16455805 (2), 15670600 (1), 15331348 (1) |
| cholesterol |
20.5 |
2 |
15817812 (1), 11668176 (1) |
| glucose |
6.75 |
6 |
15525581 (2), 18505831 (2), 15047603 (1) |
| adp |
0.961 |
1 |
15525581 (1) |
| lipid |
0 |
1 |
12218363 (1) |
Search CenterWatch for drugs/clinical trials and news about NR0B2
|
Transcripts
for NR0B2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR0B2 gene: NM_021969.2 Unigene Cluster for NR0B2: Nuclear receptor subfamily 0, group B, member 2 Hs.427055 [show with all ESTs]Unigene Representative Sequence: NM_0219691 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000254227(uc001bnf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NR0B2 (NM_021969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR0B2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR0B2 |
Additional cDNA sequence: AK310048.1 BC030207.1 HQ692833.1 3 DOTS entries: DT.312369 DT.100020812 DT.102835732 24/39 AceView cDNA sequences (see all 39): BM769196 BU156944 BQ648171 BC030207 BQ645744 BI837687 BX099712 AA872824 NM_021969 BQ082728 AI023792 BM751947 BQ650421 BQ645450 BI838435 BQ652144 BQ084480 AI801227 AI767535 BM006232 W67564 BI833566 AI248510 CD630978
GeneLoc Exon Structure
|
Expression
for NR0B2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR0B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTGCTCA
About this image
See NR0B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR0B2
SOURCE GeneReport for Unigene cluster: Hs.427055
UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466Tissue specificity: Liver. Low levels of expression were detected in heart and pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including NR0B2 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR0B2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR0B2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR0B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR0B2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR0B2 |
Orthologs
for NR0B2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NR0B2 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NR0B21 |
nuclear receptor subfamily 0, group B, member 2 |
65.7(n)
58.92(a) |
|
768353 NM_001030893.2 NP_001026064.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NR0B26 |
-- |
54(a) |
1 ↔ 1 |
GL343488.1(184037-186659) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.115902 |
Danio rerio cDNA clone IMAGE3815490, partial cds |
74.94(n) |
|
BC058069.1 |
ENSEMBL Gene Tree for NR0B2 (if available)
TreeFam Gene Tree for NR0B2 (if available) |
Paralogs
for NR0B2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NR0B2 gene
- NR0B12
1 SIMAP similar gene for NR0B2 using alignment to 2 protein entries: NR0B2_HUMAN (see all proteins):NR0B1
NR0B2 for paralogs About GeneDecksing
|
Genomic Variants
for NR0B2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NR0B2 (27237975 - 27240567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NR0B2
1 CNV: 4218
Human Gene Mutation Database (HGMD): NR0B2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR0B2 |
|
Disorders
/ Diseases
for NR0B2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NR0B2 for disorders About GeneDecksing
OMIM gene information: 604630
OMIM disorders: 601665
UniProtKB/Swiss-Prot: NR0B2_HUMAN, Q15466
Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by anincrease of body weight beyond the limitation of skeletal and physical requirements, as the result of excessiveaccumulation of body fat
20/34  diseases for NR0B2 (see all 34): About MalaCardsobesity, mild, early-onset dosage-sensitive sex reversal sex reversal anaplastic large cell lymphoma
thyroiditis severe congenital neutropenia trichosporonosis hemopneumothorax
adrenal hypoplasia insulin resistance neutropenia cholestasis
hepatopulmonary syndrome obesity myelodysplastic syndrome obesity, association with
hepatitis b purpura breast cancer duodenitis
1 disease from the University of Copenhagen DISEASES database for NR0B2:Cholestasis 5 Novoseek disease relationships for NR0B2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholestasis |
46.2 |
1 |
17108234 (1) |
| insulin resistance |
0 |
1 |
11696534 (1) |
| breast cancer |
0 |
6 |
19460704 (2) |
| tumors |
0 |
2 |
18325392 (2) |
| obesity |
0 |
5 |
11136233 (2), 15459958 (2) |
Genetic Association Database (GAD): NR0B2
Human Genome Epidemiology (HuGE) Navigator: NR0B2 (12 documents)
Export disorders for NR0B2 gene to outside databases
|
Publications
for NR0B2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR0B2 gene, integrated from 9 sources (see all 168):
(articles sorted by number of sources associating them with NR0B2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. (PubMed id 11136233)1, 2, 4, 9 Nishigori H.... Takeda J. (2001)
- Structure and expression of the orphan nuclear receptor SHP gene. (PubMed id 9603951)1, 2, 3, 9 Lee H.-K.... Choi H.-S. (1998)
- Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity. (PubMed id 15459958)1, 4, 9 Echwald S.M....Pedersen O. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. (PubMed id 15723037)1, 2 Ortlund E.A....Redinbo M.R. (2005)
- Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PubMed id 14752053)1, 2 Kim J.Y....Choi H.S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations. (PubMed id 12716767)1, 4 Hung C.C....O' Rahilly S. (2003)
- Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects. (PubMed id 12716764)1, 4 Mitchell S.M....Hattersley A.T. (2003)
- An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. (PubMed id 8650544)1, 2 Seol W.... Moore D.D. (1996)
|
External Searches for NR0B2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NR0B2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NR0B2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NR0B2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NR0B2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NR0B2 gene:
Search GeneIP for patents involving NR0B2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NR0B2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for NR0B2 | | OriGene shRNA RFP for NR0B2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR0B2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR0B2 | | | OriGene Protein Over-expression Lysate for NR0B2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NR0B2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR0B2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NR0B2 | | OriGene Custom Protein Services for NR0B2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR0B2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR0B2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR0B2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR0B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR0B2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR0B2 |
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| | | | Search Tocris compounds for NR0B2 |
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 | | | NR0B2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR0B2 |
|  |  |  | | | | ThermoFisher Antibody for NR0B2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR0B2 |
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