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NR0B1 Gene

protein-coding   GIFtS: 59

GC0XM030232
nuclear receptor subfamily 0, group B, member 1
(Previous name: dosage-sensitive sex reversal )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: AHC, DSS)
Services    

Aliases &
Descriptions
for NR0B1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
AHC 2, 3
AHCH 1, 2
AHX 2
DAX-1 2
DAX1 1, 2, 3
DSS 2
GTD 2
HHG 2
NROB1 2
OTTHUMP00000023102 2
Descriptions
DSS-AHC critical region on the X chromosome protein 1 3
Nuclear receptor DAX-1 3
dosage-sensitive sex reversal 1
nuclear hormone receptor 2
nuclear receptor subfamily 0, group B, member 1 2
External Ids
HGNC: 79601
Entrez Gene: 1902
UniProtKB: P518433
Ensembl: ENSG000001692977
Search outside databases for aliases for NR0B1 gene

Previous GC identifers: GC0XM028821 GC0XM029006 GC0XM029524 GC0XM029683 GC0XM030082

Summaries
for NR0B1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for NR0B1:
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a
dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This
protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this
gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
[provided by RefSeq]

UniProtKB/Swiss-Prot: NR0B1_HUMAN, P51843
Function: Orphan nuclear receptor. Component of a cascade required for the development of the
hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the
transcriptional activity of other nuclear receptors through heterodimeric interactions. May also
have a role in the development of the embryo and in the maintenance of embryonic stem cell
pluripotency (By similarity)

Gene Wiki entry for NR0B1 (DAX1)

Genomic Location
for NR0B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NR0B1 gene  

Entrez Gene cytogenetic band: Xp21.3-p21.2   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.3

NR0B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM030232:     (about GC identifiers)

Start:
 30,232,506 bp from pter
End:
 30,237,413 bp from pter
Size:
 4,908 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  

Proteins
for NR0B1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: NR0B1_HUMAN, P51843 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 0 group B member 1  
Size: 470 amino acids; 51718 Da
Subunit: Homodimer. Interacts with NR5A1/SF-1, NR5A2, NR0B2 and with COPS2
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus.
Homodimers exits in the cytoplasm and in the nucleus
Secondary accessions: Q96F69
Alternative splicing: 2 isoforms:  P51843-1   P51843-2   

REFSEQ proteins: NP_000466.2  

ENSEMBL proteins: 
ENSP00000368246 ENSP00000368253 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (NR0B1 / Dax1)
Human Recombinant Proteins from Abnova (NR0B1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005624 membrane fraction IDA10848616
GO:0005634 nucleus IDA16709599
GO:0005737 cytoplasm IDA16709599
GO:0042788 polysomal ribosome IDA10848616
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Antibodies for NR0B1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for NR0B1
R&D Systems Antibodies for NR0B1 (DAX1/NR0B1)
Antibodies from Abcam (NR0B1 / Dax1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NR0B1)
Novus Biologicals Antibodies for NR0B1

Assays for NR0B1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for NR0B1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR008946 Nucl_hormone_rcpt_ligand-bd
 IPR000536 Nucl_hrmn_rcpt_lig-bd_core
 IPR001723 Str_hrmn_rcpt


   GeneDecks  NR0B1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P51843

ProtoNet protein and cluster: P51843

1 Blocks protein family: IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: NR0B1_HUMAN, P51843
Domain: Homodimerization involved an interaction between amino and carboxy termini involving LXXLL
motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1/SF-1 and NROB2 through
its N-terminal LXXLL motifs
Similarity: Belongs to the nuclear hormone receptor family. NR0 subfamily

Gene Function
for NR0B1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NR0B1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NR0B1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000475

              Applied Biosystems Silencer® siRNAs for NR0B1

              Sigma-Aldrich siRNA and siRNA Panels for NR0B1  
                     Sigma-Aldrich shRNA Panels and shRNA for NR0B1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for NR0B1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000475
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000475
                                 untagged cDNA clone in CMV expression vector: NM_000475 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000475

UniProtKB/Swiss-Prot: NR0B1_HUMAN, P51843
Function: Orphan nuclear receptor. Component of a cascade required for the development of the
hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the
transcriptional activity of other nuclear receptors through heterodimeric interactions. May also
have a role in the development of the embryo and in the maintenance of embryonic stem cell
pluripotency (By similarity)

Genatlas biochemistry entry for NR0B1:
orphan nuclear (steroid/thyroid/retinoid) receptor,subfamily 0,member 1,dosage-sensitive sex
reversal,adrenal hypoplasia congenita (DSS(SRVX)-AHC) critical region on the X chromosome,likely
involved in testis and development,essential for the integrity of testicular germinal
epithelium,not required for ovarian development,also expressed in the hypothalamus and
pituitary,repressing STAR expression and suppressing steroidogenesis by binding to the STAR
promoter,antagonizing testis determining factor SRY,also antagonizing synergy between FTZF1 and
WT1,regulated by WT1 for gonadal differentiation,transcriptional suppressor of NR5A1

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nr0b1):

endocrine/exocrine glandhomeostasis/metabolismreproductive systemtumorigenesis

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0003706 ligand-regulated transcription factor activity IDA7990953
GO:0003707 steroid hormone receptor activity IEA--
GO:0003714 transcription corepressor activity IEA--
GO:0003723 RNA binding IDA10848616
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Pathways & Interactions
for NR0B1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  NR0B1  (Your Favorite Gene powered by Ingenuity) 
 Estrogen Receptor Signaling

   GeneDecks  NR0B1 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  NR0B1 


5/62 Interacting proteins for NR0B1 (P518431, 2 ENSP000003682533) via UniProtKB, MINT, and/or STRING (see all 62 )
InteractantInteraction Details
GeneCardExternal ID(s)
RORAP353981, 2EBI-946109, EBI-748689 MINT-2855726 MINT-2856905 EBI-946109, EBI-748689 MINT-2855726 MINT-2856905
RORAP353981, 2EBI-946109, EBI-748689 MINT-2855726 MINT-2856905 EBI-946109, EBI-748689 MINT-2855726 MINT-2856905
NR5A1ENSP000003626903STRING (score=.999)
NR4A1ENSP000003534273STRING (score=.991)
ARENSP000003638223STRING (score=.987)
About this table

5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006694 steroid biosynthetic process IDA9384387
GO:0006950 response to stress IEA--
GO:0007283 spermatogenesis IEA--
GO:0008104 protein localization IDA11875111
About this table

Drugs & Compounds
for NR0B1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NR0B1
9 Novoseek chemical compound relationships for NR0B1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
dmrt 71.95 1 16868052 (1)
acth 57.54 12 15879363 (1), 10931108 (1), 16392182 (1), 15956080 (1) (see all 9)
steroid 57.05 21 18827407 (2), 8961266 (2), 12536357 (1), 15523052 (1) (see all 16)
hpaii 33.73 1 15591025 (1)
progesterone 20.95 4 10098511 (1), 10403575 (1), 16901926 (1), 15464421 (1)
zinc 7.95 7 9032275 (1), 8701082 (1), 8921887 (1), 18038713 (1) (see all 6)
cholesterol 0.00 1 11713202 (1)
leucine 0.00 1 10323730 (1)
cyclic amp 0.00 2 18583320 (1)
About this table


Transcripts
for NR0B1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NR0B1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NR0B1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000475

              Sigma-Aldrich siRNA and siRNA Panels for NR0B1  
                     Sigma-Aldrich shRNA Panels and shRNA for NR0B1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000475  

REFSEQ mRNAs for NR0B1 gene: 

NM_000475.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000475  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000475
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000475
                                 untagged cDNA clone in CMV expression vector: NM_000475 

Additional cDNA sequence: 

BC011564.1 S74720.1 

4 DOTS entries:

DT.92422160  DT.75101942  DT.40193850  DT.97824504 

24/49 AceView cDNA sequences (see all 49 ):

AI681514 BE467486 BX281022 BE502995 NM_000475 BQ925068 BQ220108 BC011564 
AI693308 BM128433 AV701558 BE218036 BG287729 AA995366 BF477974 AA758389 
AI701801 BG490066 AW612655 AI027742 CK819373 BQ100800 BE045725 BI772108 

highest scoring ESTs for NR0B1:

S74720 AA555080 AA884468 AA995366 AA995755 AI027742 AI207147 AI695903 AW236930 AW612655 

Unigene Cluster for NR0B1:

Nuclear receptor subfamily 0, group B, member 1
Hs.268490  [show with all ESTs]
Unigene Representative Sequence: S74720


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000378963  ENST00000378970  

Expression
for NR0B1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NR0B1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NR0B1

1 / 2 / 3

5 probe-sets matching NR0B1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

39970_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 S74720 1.00 1.00 1.00 1

206645_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000475 0.60 1.00 0.82 1

206644_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000475 0.60 1.00 0.82 1

206645_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

206644_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGGGAAGAAT

SOURCE GeneReport for Unigene cluster: Hs.268490

Expression variation in blood from EXPOLDB for NR0B1

Orthologs
for NR0B1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for NR0B1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 NR0B11   -- nuclear receptor subfamily 0, group B, member 1 83.12(n)
74.68(a)		 491804  XM_548923.2  XP_548923.2 
chimpanzee
(Pan troglodytes)		 NR0B11   -- nuclear receptor subfamily 0, group B, member 1 99.72(n)
99.36(a)		 450140  XM_520991.2  XP_520991.2 
cow
(Bos taurus)		 NR0B11   -- nuclear receptor subfamily 0, group B, member 1 80.99(n)
73.19(a)		 281949  XM_597595.3  XP_597595.2 
rat
(Rattus norvegicus)		 Nr0b11   -- nuclear receptor subfamily 0, group B, member 1 74.33(n)
65.03(a)		 58850  NM_053317.1  NP_445769.1 
mouse
(Mus musculus)		 Nr0b11, 5 X (33.00 cM)5
 nuclear receptor subfamily 0, group B, member 11, 5 74.75(n)1
65.74(a)1		 116141  NM_007430.31  NP_031456.11 
 AK1334115  AK1412395  (see all 11)
About this table        Species with no ortholog for NR0B1

ENSEMBL Gene Tree for NR0B1

Paralogs
for NR0B1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for NR0B1 gene
NR0B22  

SNPs/Variants
for NR0B1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/36 NCBI SNPs in NR0B1 are shown (see all 36 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 22)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs48291691,2
A,C,F,H30238067(+) TTAATG/TCCATC 1 -- ng3112Minor allele frequency- T:0.11EU EA WA 836
rs126873061,2
A,C,F,H30238713(+) AGGGTG/ATTGGT 1 -- ng313Minor allele frequency- A:0.10EU EA 298
rs23011311,2
F,H30232385(-) TCTTTT/AAAAAA 1 -- ng514Minor allele frequency- A:0.01EU EA WA 418
rs38107181,2
H30237622(-) CGCTGC/TTGTTC 1 -- ng31 ese34Minor allele frequency- T:0.00EU EA WA 418
--
rs115505901,2
H30232828(-) CATTCA/TGGGAC 1 Q/L mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
rs22693451,2
A,C30236904(-) GCACGA/GCCAGG 1 R/R syn1 ese30--------
--
rs61501,2
C,F30237288(-) CAGTGC/TTGGGG 1 C/C syn1 ese32Minor allele frequency- T:0.17MN 270
rs37888901,2
A,C,F,H30233869(-) TTGCAA/CTCATC 1 -- int1 ese38Minor allele frequency- C:0.26EU EA WA 727
rs37888911,2
A,C,F,H30233837(-) TGGTCC/AACTGC 1 -- int1 ese34Minor allele frequency- A:0.44EU EA WA 414
--
rs110951801,2
A,F30235420(+) GAAGAC/TAGGAC 1 -- int14Minor allele frequency- T:0.10NA EA 362
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HapMap Linkage Disequilibrium images for NR0B1 (up to first 250kb)

Disorders & Mutations
for NR0B1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300473

UniProtKB/Swiss-Prot: NR0B1_HUMAN, P51843
  • Defects in NR0B1 are the cause of X-linked adrenal hypoplasia congenital (AHC)
    [MIM:300200]. AHC is a developmental disorder of the adrenal gland that results in profound
    hormonal deficiencies and is lethal if untreated. It is characterized by the absence of the
    permanent zone of the adrenal cortex and by a structural disorganization of the glands.
    Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a
    condition resulting from or characterized by abnormally decreased gonadal function, with
    retardation of growth and sexual development
  • XY individuals with a duplication of part of the short arm of the X chromosome and an
    intact SRY gene show dosage-sensitive sex reversal (DSS) [MIM:300018]. The single X chromosome in
    these individuals does not undergo X-chromosome inactivation; therefore, these individuals
    presumably carry 2 active copies of genes, including the NR0B1 gene, in the duplicated region.
    Individuals with deletion of this region develop as males. Genes within the DSS region are,
    therefore, not essential for testis development, but, when present in a double dose, interfere
    with testis formation

    • 10/40 Novoseek disease relationships for NR0B1 gene (see all 40 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adrenal hypoplasia, congenital 97.26 42 8636263 (3), 15800903 (2), 9709929 (2), 10323730 (2) (see all 29)
    addisons disease 96.96 179 18339285 (4), 16355812 (3), 18038713 (3), 10341858 (3) (see all 99)
    glycerol kinase deficiency 86.64 5 15300857 (2), 9195207 (1), 15860922 (1)
    kallmann syndrome 75.17 6 10714361 (1), 12536356 (1), 10727999 (1), 10527669 (1) (see all 5)
    hypogonadism 71.11 14 10341858 (3), 17803711 (2), 10361383 (1), 12943739 (1) (see all 11)
    adrenal disease 70.39 1 8756567 (1)
    metaphyseal dysplasia 68.77 2 17986825 (1)
    puberty delayed 62.63 1 10599709 (1)
    carcinoma adrenocortical 59.87 9 18824868 (3), 9232190 (2), 15879363 (1), 18819054 (1) (see all 6)
    hypoplasia 58.75 25 15044589 (2), 12610109 (2), 18417736 (2), 16459121 (1) (see all 14)
    About this table

    GeneTests: NR0B1
    X-Linked Adrenal Hypoplasia Congenita

    Human Gene Mutation Database: NR0B1

    Medical News
    for NR0B1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for NR0B1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/263 PubMed articles for NR0B1 gene (see all 263 ):

    Search for NR0B1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NR0B1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 190 HGNC: 7960 AceView: NR0B1 Ensembl:ENSG00000169297 euGenes: HUgn190
    ECgene: NR0B1 H-InvDB: NR0B1

    Other Databases showing NR0B1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing NR0B1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=NR0B1

    Licensable Technologies
    for NR0B1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NR0B1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NR0B1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NR0B1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NR0B1 Antibodies for NR0B1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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