Aliases for NQO2 Gene
External Ids for NQO2 Gene
Previous HGNC Symbols for NQO2 Gene
Previous GeneCards Identifiers for NQO2 Gene
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for NQO2 Gene
NQO2 (NAD(P)H Dehydrogenase, Quinone 2) is a Protein Coding gene. Diseases associated with NQO2 include marburg hemorrhagic fever and brca1 and brca2 hereditary breast and ovarian cancer. GO annotations related to this gene include oxidoreductase activity and NADPH dehydrogenase (quinone) activity. An important paralog of this gene is NQO1.
UniProtKB/Swiss-Prot for NQO2 Gene
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.