Aliases for NQO2 Gene
External Ids for NQO2 Gene
Previous HGNC Symbols for NQO2 Gene
Previous GeneCards Identifiers for NQO2 Gene
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for NQO2 Gene
NQO2 (N-Ribosyldihydronicotinamide:Quinone Reductase 2) is a Protein Coding gene. Diseases associated with NQO2 include Marburg Hemorrhagic Fever and Brca1 And Brca2 Hereditary Breast And Ovarian Cancer. Among its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include oxidoreductase activity and NADPH dehydrogenase (quinone) activity. An important paralog of this gene is NQO1.
UniProtKB/Swiss-Prot for NQO2 Gene
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.