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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NQO2 Gene

protein-coding GIFtS: 60
GCID: GC06P003000

NAD(P)H dehydrogenase, quinone 2

(Previous names: NAD(P)H menadione oxidoreductase 2, dioxin-inducible )
(Previous symbol: NMOR2)

Explore 22 diseases affiliated with
NQO2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NAD(P)H Dehydrogenase, Quinone 2¹ ²		NRH Dehydrogenase [Quinone] 2² ³
NMOR2¹ ² ³ ⁵		NRH:Quinone Oxidoreductase 2² ³
QR2¹ ² ³		NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2²
DHQV¹ ²		Ribosyldihydronicotinamide Dehydrogenase²
DIA6¹ ²		Ribosyldihydronicotinamide Dehydrogenase [Quinone]²
NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible¹ ²		EC 1.10.99.2³
Quinone Reductase 2² ³

External Ids:	HGNC: 7856¹	Entrez Gene: 4835²	Ensembl: ENSG00000124588⁷	OMIM: 160998⁵	UniProtKB: P16083³

Export aliases for NQO2 gene to outside databases

Previous GC identifers: GC06P002985 GC06P002945 GC06P002873

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NQO2:

NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the

vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu

et al., 1997 (PubMed 9367528)).(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones

involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent

gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NQO2 gene promoter:
Sp1 AP-1 ATF-2 c-Jun C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NQO2 promoter sequence

Search SABiosciences Chromatin IP Primers for NQO2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NQO2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2 Ensembl cytogenetic band: 6p25.2 HGNC cytogenetic band: 6p25.2

NQO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NQO2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P003000: view genomic region (about GC identifiers)

Start:	2,988,221 bp from pter	End:	3,019,996 bp from pter
Size:	31,776 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083 (See protein sequence)

Recommended Name: Ribosyldihydronicotinamide dehydrogenase [quinone]

Size: 231 amino acids; 25919 Da

Cofactor: Binds 1 zinc ion per subunit

Cofactor: FAD

Subunit: Homodimer

Subcellular location: Cytoplasm

Miscellaneous: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor

6/40 PDB 3D structures from and Proteopedia for NQO2 (see all 40):

1QR2 (3D)

1SG0 (3D)

1XI2 (3D)

1ZX1 (3D)

2BZS (3D)

2QMY (3D)

Secondary accessions: B2R492 Q5TD04

Explore the universe of human proteins at neXtProt for NQO2: NX_P16083

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16083

NQO2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000895.2

ENSEMBL proteins:

ENSP00000406951 ENSP00000369839 ENSP00000380829 ENSP00000337773 ENSP00000369806

ENSP00000369822 ENSP00000369821 ENSP00000369795

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	ProSpec Recombinant Protein for NQO2
	Uscn Proteins for NQO2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

NQO2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NQO2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NQO2 for domains About GeneDecksing

1 InterPro domain/family:

IPR003680 Flavodoxin_fold

Graphical View of Domain Structure for InterPro Entry P16083

ProtoNet protein and cluster: P16083

1 Blocks protein family: IPB003680 NAD(P)H dehydrogenase (quinone)

UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones

involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent

gamma-carboxylation of glutamate residues in prothrombin synthesis

Catalytic activity: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide

+ a hydroquinone

Enzyme regulation: Inhibited by melatonin, resveratrol and 5-hydroxytryptamine

Biophysicochemical properties: Kinetic parameters: KM=28 uM for NRH; KM=11.6 uM for menadione; KM=252 uM for NADH;

Enzyme Number (IUBMB): EC 1.10.99.2¹

miRNA Products:		OriGene 3'-UTR Clone: NQO2 Browse MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate NQO2:
		hsa-miR-590-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001512	dihydronicotinamide riboside quinone reductase activity	IEA	--
GO:0008753	NADPH dehydrogenase (quinone) activity	TAS	1691923
GO:0009055	electron carrier activity	TAS	1691923
GO:0046872	metal ion binding	IEA	--

NQO2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NQO2:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for NQO2: Nqo2^tm1Akj Nqo2^tm1Bout
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nqo2):

behavior/neurological	cellular	hematopoietic system	homeostasis/metabolism	immune system
integument	tumorigenesis

NQO2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NQO2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/7 Interacting proteins for NQO2 (P16083^{2, 3} ENSP00000337773⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELB	Q01201²^,³	MINT-49032 I2D: score=2
RHOB	P62745³, ENSP00000272233⁴	I2D: score=2 STRING: ENSP00000272233
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
GORASP2	Q9H8Y8³, ENSP00000234160⁴	I2D: score=4 STRING: ENSP00000234160
MAGEA11	P43364³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007613	memory	IEA	--

NQO2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NQO2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NQO2

7 HMDB Compounds for NQO2 About this table

Compound	Synonyms	CAS #	PubMed Ids
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide	Reduced nicotinamide riboside (see all 3)	--	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Hydroquinone	1,4-Benzenediol (see all 35)	123-31-9	--
Menadione	Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)	58-27-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
Nicotinamide riboside	1-b-D-ribosyl-3-Pyridinecarboxamide (see all 12)	1341-23-7	--
Quinone	1,4-Benzoquine (see all 25)	106-51-4	--

10/12 DrugBank Compounds for NQO2 (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Menadione	2-Methyl-1,4-Naphthalenedione (see all 7)	58-27-5	target	--	15078100 12351651 16765324 15733542 10433694
Flavin-Adenine Dinucleotide	--	146-14-5	target	--	17139284 17016423
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17031400 16905546
Resveratrol	(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol (see all 9)	501-36-0	target	--	15350128 15381063
(3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione	--	--	target	--	10592235
10-Propargyl-5,8-Dideazafolic Acid	--	--	target	--	10592235
5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one	--	--	target	--	10592235
6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one	--	--	target	--	10592235
CB1954	--	--	target	--	10592235
Melatonin	MEL (see all 4)	73-31-4	target	--	19463840

10/21 Novoseek chemical compound relationships for NQO2 gene (see all 21) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
quinone	91.6	99	18579530 (7), 15733542 (5), 15350128 (3), 18254726 (3) (see all 52)
cb1954	87.4	6	16129418 (2), 18062662 (2), 9367528 (1)
menadione	75.7	7	18374191 (1), 15733542 (1), 1691923 (1), 18254726 (1) (see all 6)
melatonin	68.7	46	18254726 (5), 17910598 (4), 16293234 (3), 18502195 (2) (see all 14)
2[125i]iodomelatonin	68.1	3	18254726 (1)
dicoumarol	63	3	11154737 (1), 9367528 (1)
tbhq	57.6	3	16545679 (2)
resveratrol	54.8	30	18671725 (7), 15350128 (5), 15993843 (3), 19767760 (2)
beta-naphthoflavone	45	2	8182056 (1)
nadph	44.5	6	11154737 (1), 18538895 (1), 9050836 (1), 17031400 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about NQO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NQO2 gene:

NM_000904.3

Unigene Clusters for NQO2:

NAD(P)H dehydrogenase, quinone 2

Hs.145597 [show with all ESTs], Hs.533050 [show with all ESTs]

Unigene Representative Sequences: AK097187, AK056981

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000426637 ENST00000380472(uc003mup.1) ENST00000397717 ENST00000338130(uc003mus.2 uc003mut.2)

ENST00000380441 ENST00000380455 ENST00000380454 ENST00000380430

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Additional cDNA sequence:

AK056981.1 AK311746.1 BC006096.2 J02888.1

17 DOTS entries:

DT.452875 DT.100797292 DT.100017506 DT.65284171 DT.97847745 DT.95173411 DT.100797286 DT.102827444

DT.121352982 DT.216153 DT.100683819 DT.92426442 DT.92426448 DT.98083451 DT.99997381 DT.65284170

DT.91654768

24/260 AceView cDNA sequences (see all 260):

BU607941 BQ184931 AK056981 BQ185566 CA310341 BF689694 CN479098 BM683654

CK300956 BX280672 CD369046 BQ226005 BU626474 BQ025114 AI216650 CD366005

CR600371 BM683688 BM824959 CA308279 BM798996 BM984758 AW005149 AI492470

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b
SP1:							-						-
SP2:							-		-		-		-		-
SP3:							-		-		-		-		-												-		-
SP4:									-		-		-		-
SP5:							-		-		-		-		-				-		-

ECgene alternative splicing isoforms for NQO2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NQO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAGACTTT

About this image
See NQO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NQO2

SOURCE GeneReport for Unigene clusters: Hs.145597 Hs.533050

SABiosciences Expression via Pathway-Focused PCR Array including NQO2:

Drug Metabolism: Phase II Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NQO2 gene from 6/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nqo2^{1 , 5}	NAD(P)H dehydrogenase, quinone 2^{1, 5}	82.68(n)¹ 81.66(a)¹		13 (14.01 cM)⁵ 18105¹ NM_001163241.1¹ NP_001156713.1¹ 33964659⁵
chicken (Gallus gallus)	Aves	NQO2¹	NAD(P)H dehydrogenase, quinone 2	71.62(n) 71.18(a)		420886 XM_418973.3 XP_418973.1
lizard (Anolis carolinensis)	Reptilia	NQO2⁶	--	62(a)	1 ↔ 1	GL343247.1(945747-950320)
zebrafish (Danio rerio)	Actinopterygii	nqo1⁶	NAD(P)H dehydrogenase, quinone 1	41(a)	1 ↔ 1	7(57966520-57985583)
honey bee (Apis mellifera)	Insecta	--	--	24(a)	possible ortholog	GroupUn.6733(491-1051)
E. coli (Escherichia coli)	Gamma proteobacteria	kefG⁶ kefF⁶ (see all 3)	potassium-efflux system ancillary protein for KefB... potassium-efflux system ancillary protein for KefC... (see all 3)	33(a) 32(a) (see all 3)	possible ortholog possible ortholog (see all 3)	Chromosome(3478629-3479183) Chromosome(47246-47776)

ENSEMBL Gene Tree for NQO2 (if available)
TreeFam Gene Tree for NQO2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NQO2 gene

NQO1²

1 SIMAP similar gene for NQO2 using alignment to 4 protein entries: NQO2_HUMAN (see all proteins):

NQO1

NQO2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NQO2
PGOHUM00000243468

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7746724^1,2	C,F,	--	2998075(+)	`CTTTAT/CGTTAT`	1	--	us2k¹		5		WA CSA NA	244
rs111973955^1,2	C,	--	2998116(+)	`GATGCT/GGGTAG`	1	--	us2k¹		2		WA	120
rs7760137^1,2	C,F,A,H,	--	2998124(+)	`TAGCAG/CAAGGG`	1	--	us2k¹ trp³		11		NA WA CSA EA	374
rs7742813^1,2	C,F,A,H,	--	2998164(+)	`CAATGA/TCCTCT`	1	--	us2k¹		11		NA WA CSA EA	374
rs7760327^1,2	C,	--	2998248(+)	`GGGGCG/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs6596927^1,2	C,F,A,H,	--	2998319(+)	`CTTGCA/TTTCCA`	1	--	us2k¹		4		WA NA	8
rs6596928^1,2	C,F,A,H,	--	2998349(+)	`GAAAAG/TTGAGA`	1	--	us2k¹		5		NA WA	244
rs140387934^1,2		--	2998384(+)	`TTTGTC/TGTTGG`	1	--	us2k¹		0	--	--	--	--
rs114209458^1,2	F,	--	2998416(+)	`GTAGCA/GTGACC`	1	--	us2k¹		1		NA	120
rs144829824^1,2		--	2998452(+)	`ATGGTC/TAATCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NQO2 (2988221 - 3019996 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NQO2
1 CNV: 2617
Human Gene Mutation Database (HGMD): NQO2

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NQO2 for disorders           About GeneDecksing

OMIM gene information: 160998
OMIM disorders: 114480
20/22 diseases for NQO2 (see all 22):    About MalaCards

substance dependence breast cancer susceptibility acute myeloid leukemia herpes simplex

myeloid leukemia hepatoblastoma parkinson's disease alcoholic pancreatitis

rubella myelodysplastic syndrome breast cancer schizophrenia

alcoholism pancreatitis ovarian cancer gastric cancer

influenza pancreatic cancer leukemia melanoma

7 Novoseek disease relationships for NQO2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatoblastoma	48.9	4	1691923 (1), 8182056 (1)
agranulocytosis	32.1	1	14617031 (1)
parkinson disease	30	6	18314446 (2), 11688992 (1), 15451063 (1), 18579530 (1) (see all 5)
cancer	13	6	10945627 (1), 16129418 (1), 17643990 (1), 18062662 (1)
melanoma	9.46	2	15993843 (2)
schizophrenia	8.78	6	14639047 (4), 16955993 (1)
tumors	0.903	7	18794327 (3), 14529407 (2), 11809856 (1), 16955993 (1)

Genetic Association Database (GAD): NQO2
Human Genome Epidemiology (HuGE) Navigator: NQO2 (20 documents)

Export disorders for NQO2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NQO2 gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with NQO2)

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Crystal structure of quinone reductase 2 in complex with resveratrol. (PubMed id 15350128)^{1, 2, 7, 9} Buryanovskyy L....Zhang Z. (2004)
Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PubMed id 1691923)^{1, 2, 3, 9} Jaiswal A.K.... McBride O.W. (1990)
Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PubMed id 15078100)^{1, 2, 7, 9} Kwiek J.J.... Rudolph J. (2004)
Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PubMed id 10433694)^{1, 2, 7, 9} Foster C.E.... Amzel L.M. (1999)
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase. (PubMed id 9367528)^{1, 2, 9} Wu K.... Chen S. (1997)
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. (PubMed id 18254726)^{1, 2, 9} Calamini B.... Mesecar A.D. (2008)
Human NAD(P)H:quinone oxidoreductase 2. Gene structure, activity, and tissue-specific expression. (PubMed id 8182056)^{1, 2, 9} Jaiswal A.K. (1994)
Quinone reductase 2 is a catechol quinone reductase. (PubMed id 18579530)^{1, 2, 9} Fu Y.... Zhang Z. (2008)
A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia. (PubMed id 14639047)^{1, 4, 9} Harada S....Kawanishi Y. (2003)
Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms. (PubMed id 12960511)^{1, 4, 9} Okubo T....Matsushita S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4835	HGNC: 7856	AceView: NQO2andDKFZp686I15217	Ensembl:ENSG00000124588	euGenes: HUgn4835
ECgene: NQO2	H-InvDB: NQO2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NQO2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/nqo2/

Intellectual Property for NQO2 gene
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Patent Information for NQO2 gene:
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GeneCards and IP:
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NAD(P)H dehydrogenase, quinone 2

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NAD(P)H dehydrogenase, quinone 2

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