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Aliases for NQO2 Gene

Aliases for NQO2 Gene

  • NAD(P)H Quinone Dehydrogenase 2 2 3
  • NAD(P)H Dehydrogenase, Quinone 2 2 3 5
  • NRH:Quinone Oxidoreductase 2 3 4
  • Quinone Reductase 2 3 4
  • NMOR2 3 4
  • QR2 3 4
  • NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2 3
  • NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible 2
  • Ribosyldihydronicotinamide Dehydrogenase 3
  • NRH Dehydrogenase [Quinone] 2 4
  • EC 1.10.5.1 4
  • DHQV 3
  • DIA6 3

External Ids for NQO2 Gene

Previous HGNC Symbols for NQO2 Gene

  • NMOR2

Previous GeneCards Identifiers for NQO2 Gene

  • GC06P002985
  • GC06P002945
  • GC06P002873
  • GC06P003000

Summaries for NQO2 Gene

Entrez Gene Summary for NQO2 Gene

  • This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for NQO2 Gene

NQO2 (NAD(P)H Quinone Dehydrogenase 2) is a Protein Coding gene. Diseases associated with NQO2 include Marburg Hemorrhagic Fever and Brca1 And Brca2 Hereditary Breast And Ovarian Cancer. GO annotations related to this gene include oxidoreductase activity and NADPH dehydrogenase (quinone) activity. An important paralog of this gene is NQO1.

UniProtKB/Swiss-Prot for NQO2 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NQO2 Gene

Genomics for NQO2 Gene

Regulatory Elements for NQO2 Gene

Enhancers for NQO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NQO2 on UCSC Golden Path with GeneCards custom track

Promoters for NQO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NQO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NQO2 Gene

Chromosome:
6
Start:
2,987,987 bp from pter
End:
3,028,869 bp from pter
Size:
40,883 bases
Orientation:
Plus strand

Genomic View for NQO2 Gene

Genes around NQO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO2 Gene

Proteins for NQO2 Gene

  • Protein details for NQO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16083-NQO2_HUMAN
    Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein Accession:
    P16083
    Secondary Accessions:
    • B2R492
    • Q5TD04

    Protein attributes for NQO2 Gene

    Size:
    231 amino acids
    Molecular mass:
    25919 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

    Three dimensional structures from OCA and Proteopedia for NQO2 Gene

neXtProt entry for NQO2 Gene

Proteomics data for NQO2 Gene at MOPED

Post-translational modifications for NQO2 Gene

  • Ubiquitination at Lys 16
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NQO2 Gene

Domains & Families for NQO2 Gene

Protein Domains for NQO2 Gene

Suggested Antigen Peptide Sequences for NQO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16083

UniProtKB/Swiss-Prot:

NQO2_HUMAN :
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO2: view

No data available for Gene Families for NQO2 Gene

Function for NQO2 Gene

Molecular function for NQO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=28 uM for NRH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=11.6 uM for menadione {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=252 uM for NADH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528};
UniProtKB/Swiss-Prot CatalyticActivity:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.
UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Enzyme Numbers (IUBMB) for NQO2 Gene

Gene Ontology (GO) - Molecular Function for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008753 NADPH dehydrogenase (quinone) activity TAS 1691923
genes like me logo Genes that share ontologies with NQO2: view
genes like me logo Genes that share phenotypes with NQO2: view

Animal Models for NQO2 Gene

MGI Knock Outs for NQO2:

Animal Model Products

miRNA for NQO2 Gene

miRTarBase miRNAs that target NQO2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NQO2 Gene

Localization for NQO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NQO2 Gene COMPARTMENTS Subcellular localization image for NQO2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NQO2: view

Pathways & Interactions for NQO2 Gene

SuperPathways for NQO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NQO2: view

No data available for Pathways by source and SIGNOR curated interactions for NQO2 Gene

Drugs & Compounds for NQO2 Gene

(24) Drugs for NQO2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target 207
Melatonin Approved Nutra Antagonist, Target Melatonin receptors MT inhibitor 239
FAD Approved Pharma Target 0
Primaquine Approved Pharma Target, inhibitor 72
Dabigatran etexilate Approved Pharma Enzyme, inhibitor 0

(13) Additional Compounds for NQO2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • 1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • 1-(beta-delta-Ribofuranosyl)-1,4-dihydronicotinamide
  • Reduced nicotinamide riboside
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • 1-b-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-delta-Ribosyl-3-Pyridinecarboxamide
  • 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium
1341-23-7

(1) ApexBio Compounds for NQO2 Gene

Compound Action Cas Number
DMXAA (Vadimezan) Tumnor vascular disrupting agent, apoptosis inducer 117570-53-3
genes like me logo Genes that share compounds with NQO2: view

Transcripts for NQO2 Gene

Unigene Clusters for NQO2 Gene

NAD(P)H dehydrogenase, quinone 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for NQO2 Gene

GeneLoc Exon Structure for
NQO2
ECgene alternative splicing isoforms for
NQO2

Expression for NQO2 Gene

mRNA expression in normal human tissues for NQO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO2 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for NQO2 Gene

This gene is overexpressed in Liver, secretome (8.1) and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NQO2 Gene



SOURCE GeneReport for Unigene cluster for NQO2 Gene Hs.145597

genes like me logo Genes that share expression patterns with NQO2: view

Protein tissue co-expression partners for NQO2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NQO2 Gene

Orthologs for NQO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NQO2 35
  • 81.53 (n)
  • 80.09 (a)
NQO2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NQO2 35
  • 82.97 (n)
  • 83.12 (a)
NQO2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo2 35
  • 82.68 (n)
  • 81.66 (a)
Nqo2 16
Nqo2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NQO2 35
  • 98.85 (n)
  • 98.7 (a)
NQO2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nqo2 35
  • 82.68 (n)
  • 80.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NQO2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NQO2 35
  • 71.62 (n)
  • 71.18 (a)
NQO2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO2 36
  • 64 (a)
OneToOne
Species with no ortholog for NQO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NQO2 Gene

ENSEMBL:
Gene Tree for NQO2 (if available)
TreeFam:
Gene Tree for NQO2 (if available)

Paralogs for NQO2 Gene

Paralogs for NQO2 Gene

(1) SIMAP similar genes for NQO2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NQO2 Gene

genes like me logo Genes that share paralogs with NQO2: view

Variants for NQO2 Gene

Sequence variations from dbSNP and Humsavar for NQO2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs28383623 - 3,010,064(+) ACCCA(A/G)GTCTT reference, missense
rs17136117 - 3,010,103(+) AGATG(A/G)ACTGA reference, missense
rs1143684 - 3,010,156(+) TGAAC(C/T)TTGAG reference, missense
rs17300141 - 3,012,544(+) GACAG(A/G)TACTC reference, missense
rs28383651 - 3,019,510(+) TAAAG(C/T)CCTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NQO2 Gene

Variant ID Type Subtype PubMed ID
nsv830575 CNV Loss 17160897
nsv883398 CNV Loss 21882294
dgv6429n71 CNV Loss 21882294
dgv1900e1 CNV Complex 17122850
nsv5177 CNV Insertion 18451855
nsv883401 CNV Loss 21882294
nsv883402 CNV Loss 21882294
nsv523441 CNV Loss 19592680
nsv470795 CNV Gain 18288195

Variation tolerance for NQO2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NQO2 Gene

Human Gene Mutation Database (HGMD)
NQO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NQO2 Gene

Disorders for NQO2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NQO2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
marburg hemorrhagic fever
  • marburg disease
brca1 and brca2 hereditary breast and ovarian cancer
  • hboc
alcoholic pancreatitis
  • pancreatitis alcoholic
breast cancer
  • breast cancer, invasive ductal
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search NQO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NQO2

Genetic Association Database (GAD)
NQO2
Human Genome Epidemiology (HuGE) Navigator
NQO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NQO2
genes like me logo Genes that share disorders with NQO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO2 Gene

Publications for NQO2 Gene

  1. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PMID: 1691923) Jaiswal A.K. … McBride O.W. (Biochemistry 1990) 2 3 4 23 67
  2. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PMID: 15078100) Kwiek J.J. … Rudolph J. (Biochemistry 2004) 3 23 25 26
  3. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PMID: 10433694) Foster C.E. … Amzel L.M. (Biochemistry 1999) 3 23 25 26
  4. Quinone reductase 2 substrate specificity and inhibition pharmacology. (PMID: 15733542) Boutin J.A. … Ferry G. (Chem. Biol. Interact. 2005) 23 25 26
  5. Crystal structure of quinone reductase 2 in complex with resveratrol. (PMID: 15350128) Buryanovskyy L. … Zhang Z. (Biochemistry 2004) 3 23 25

Products for NQO2 Gene

Sources for NQO2 Gene

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