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Aliases for NQO2 Gene

Aliases for NQO2 Gene

  • NAD(P)H Dehydrogenase, Quinone 2 2 3
  • NMOR2 3 4 6
  • NRH:Quinone Oxidoreductase 2 3 4
  • Quinone Reductase 2 3 4
  • QR2 3 4
  • NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2 3
  • NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible 2
  • Ribosyldihydronicotinamide Dehydrogenase [Quinone] 3
  • Ribosyldihydronicotinamide Dehydrogenase 3
  • NRH Dehydrogenase [Quinone] 2 4
  • EC 1.10.99.2 4
  • DHQV 3
  • DIA6 3

External Ids for NQO2 Gene

Previous HGNC Symbols for NQO2 Gene

  • NMOR2

Previous GeneCards Identifiers for NQO2 Gene

  • GC06P002985
  • GC06P002945
  • GC06P002873
  • GC06P003000

Summaries for NQO2 Gene

Entrez Gene Summary for NQO2 Gene

  • This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for NQO2 Gene

NQO2 (NAD(P)H Dehydrogenase, Quinone 2) is a Protein Coding gene. Diseases associated with NQO2 include alcoholic pancreatitis and brca1 and brca2 hereditary breast and ovarian cancer. GO annotations related to this gene include electron carrier activity and dihydronicotinamide riboside quinone reductase activity. An important paralog of this gene is NQO1.

UniProtKB/Swiss-Prot for NQO2 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NQO2 Gene

Genomics for NQO2 Gene

Regulatory Elements for NQO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NQO2 Gene

Start:
2,987,987 bp from pter
End:
3,028,869 bp from pter
Size:
40,883 bases
Orientation:
Plus strand

Genomic View for NQO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NQO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO2 Gene

Proteins for NQO2 Gene

  • Protein details for NQO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16083-NQO2_HUMAN
    Recommended name:
    Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein Accession:
    P16083
    Secondary Accessions:
    • B2R492
    • Q5TD04

    Protein attributes for NQO2 Gene

    Size:
    231 amino acids
    Molecular mass:
    25919 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor

    Three dimensional structures from OCA and Proteopedia for NQO2 Gene

neXtProt entry for NQO2 Gene

Proteomics data for NQO2 Gene at MOPED

Post-translational modifications for NQO2 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NQO2 Gene

Domains for NQO2 Gene

Protein Domains for NQO2 Gene

Suggested Antigen Peptide Sequences for NQO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16083

UniProtKB/Swiss-Prot:

NQO2_HUMAN :
  • P16083
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO2: view

No data available for Gene Families for NQO2 Gene

Function for NQO2 Gene

Molecular function for NQO2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=28 uM for NRH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=11.6 uM for menadione {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528}; KM=252 uM for NADH {ECO:0000269 PubMed:15078100, ECO:0000269 PubMed:9367528};
UniProtKB/Swiss-Prot CatalyticActivity: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.
UniProtKB/Swiss-Prot Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Enzyme Numbers (IUBMB) for NQO2 Gene

Gene Ontology (GO) - Molecular Function for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001512 dihydronicotinamide riboside quinone reductase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008753 NADPH dehydrogenase (quinone) activity TAS 1691923
GO:0009055 electron carrier activity TAS 1691923
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with NQO2: view
genes like me logo Genes that share phenotypes with NQO2: view

Animal Models for NQO2 Gene

MGI Knock Outs for NQO2:

Animal Model Products

CRISPR Products

miRNA for NQO2 Gene

miRTarBase miRNAs that target NQO2

No data available for Transcription Factor Targeting and HOMER Transcription for NQO2 Gene

Localization for NQO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NQO2 Gene COMPARTMENTS Subcellular localization image for NQO2 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NQO2: view

Pathways for NQO2 Gene

SuperPathways for NQO2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NQO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007613 memory IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NQO2: view

No data available for Pathways by source for NQO2 Gene

Compounds for NQO2 Gene

(7) HMDB Compounds for NQO2 Gene

Compound Synonyms Cas Number PubMed IDs
1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide
  • Reduced nicotinamide riboside
Not Available
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Hydroquinone
  • 1,4-Benzenediol
123-31-9
Menadione
  • Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
58-27-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(21) Novoseek inferred chemical compound relationships for NQO2 Gene

Compound -log(P) Hits PubMed IDs
quinone 91.6 76
cb1954 87.4 5
menadione 75.7 6
melatonin 68.7 25
2[125i]iodomelatonin 68.1 1

(2) PharmGKB related drug/compound annotations for NQO2 Gene

Drug/compound Annotation
cyclophosphamide CA
doxorubicin CA
genes like me logo Genes that share compounds with NQO2: view

Transcripts for NQO2 Gene

Unigene Clusters for NQO2 Gene

NAD(P)H dehydrogenase, quinone 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NQO2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - -

Relevant External Links for NQO2 Gene

GeneLoc Exon Structure for
NQO2
ECgene alternative splicing isoforms for
NQO2

Expression for NQO2 Gene

mRNA expression in normal human tissues for NQO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO2 Gene

This gene is overexpressed in Whole Blood (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NQO2 Gene

SOURCE GeneReport for Unigene cluster for NQO2 Gene Hs.145597

genes like me logo Genes that share expressions with NQO2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NQO2 Gene

Orthologs for NQO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NQO2 35
  • 98.85 (n)
  • 98.7 (a)
NQO2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NQO2 35
  • 81.53 (n)
  • 80.09 (a)
NQO2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NQO2 35
  • 82.97 (n)
  • 83.12 (a)
NQO2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo2 35
  • 82.68 (n)
  • 81.66 (a)
Nqo2 16
Nqo2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NQO2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nqo2 35
  • 82.68 (n)
  • 80.79 (a)
chicken
(Gallus gallus)
Aves NQO2 35
  • 71.62 (n)
  • 71.18 (a)
NQO2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO2 36
  • 64 (a)
OneToOne
Species with no ortholog for NQO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NQO2 Gene

ENSEMBL:
Gene Tree for NQO2 (if available)
TreeFam:
Gene Tree for NQO2 (if available)

Paralogs for NQO2 Gene

Paralogs for NQO2 Gene

Selected SIMAP similar genes for NQO2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NQO2 Gene

genes like me logo Genes that share paralogs with NQO2: view

Variants for NQO2 Gene

Sequence variations from dbSNP and Humsavar for NQO2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1022733 -- 3,016,510(+) ATACT(A/G/T)AGTAA intron-variant
rs1049115 -- 3,015,556(+) GTGCC(A/G)GCCAT reference, synonymous-codon, intron-variant
rs1130428 -- 3,016,904(+) CTTTC(C/T)GTAAC reference, synonymous-codon
rs1143684 - 3,010,156(+) TGAAC(C/T)TTGAG reference, missense
rs1273169 -- 3,006,384(-) TGCTT(C/T)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NQO2 Gene

Variant ID Type Subtype PubMed ID
nsv830575 CNV Loss 17160897
nsv883398 CNV Loss 21882294
dgv6429n71 CNV Loss 21882294
dgv1900e1 CNV Complex 17122850
nsv5177 CNV Insertion 18451855
nsv883401 CNV Loss 21882294
nsv883402 CNV Loss 21882294
nsv523441 CNV Loss 19592680
nsv470795 CNV Gain 18288195

Relevant External Links for NQO2 Gene

HapMap Linkage Disequilibrium report
NQO2
Human Gene Mutation Database (HGMD)
NQO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NQO2 Gene

Disorders for NQO2 Gene

(1) OMIM Diseases for NQO2 Gene (160998)

(7) Novoseek inferred disease relationships for NQO2 Gene

Disease -log(P) Hits PubMed IDs
hepatoblastoma 48.9 2
agranulocytosis 32.1 1
parkinson disease 30 6
cancer 13 4
melanoma 9.46 2

Relevant External Links for NQO2

Genetic Association Database (GAD)
NQO2
Human Genome Epidemiology (HuGE) Navigator
NQO2
genes like me logo Genes that share disorders with NQO2: view

No data available for UniProtKB/Swiss-Prot for NQO2 Gene

Publications for NQO2 Gene

  1. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PMID: 1691923) Jaiswal A.K. … McBride O.W. (Biochemistry 1990) 2 3 4 23
  2. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PMID: 15078100) Kwiek J.J. … Rudolph J. (Biochemistry 2004) 3 4 23 25
  3. Crystal structure of quinone reductase 2 in complex with resveratrol. (PMID: 15350128) Buryanovskyy L. … Zhang Z. (Biochemistry 2004) 3 4 23 25
  4. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PMID: 10433694) Foster C.E. … Amzel L.M. (Biochemistry 1999) 3 4 23 25
  5. Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms. (PMID: 12960511) Okubo T. … Matsushita S. (Alcohol. Clin. Exp. Res. 2003) 3 23 48

Products for NQO2 Gene

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