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NQO2 Gene

protein-coding   GIFtS: 64
GCID: GC06P003006

NAD(P)H Dehydrogenase, Quinone 2

(Previous names: NAD(P)H menadione oxidoreductase 2, dioxin-inducible)
(Previous symbol: NMOR2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NAD(P)H Dehydrogenase, Quinone 21 2     DIA62
NMOR21 2 3 5     NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-22
Quinone Reductase 22 3     Ribosyldihydronicotinamide Dehydrogenase2
QR22 3     Ribosyldihydronicotinamide Dehydrogenase [Quinone]2
NRH:Quinone Oxidoreductase 22 3     EC 1.10.99.23
NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible1     NRH Dehydrogenase [Quinone] 23
DHQV2     

External Ids:    HGNC: 78561   Entrez Gene: 48352   Ensembl: ENSG000001245887   OMIM: 1609985   UniProtKB: P160833   

Export aliases for NQO2 gene to outside databases

Previous GC identifers: GC06P002985 GC06P002945 GC06P002873 GC06P003000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NQO2 Gene:
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed
flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide
riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and
several cancers. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for NQO2 Gene:
NQO2 (NAD(P)H dehydrogenase, quinone 2) is a protein-coding gene. Diseases associated with NQO2 include brca1 and brca2 hereditary breast and ovarian cancer, and alcoholic pancreatitis. GO annotations related to this gene include dihydronicotinamide riboside quinone reductase activity and electron carrier activity. An important paralog of this gene is NQO1.

UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083
Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of
hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin
K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NQO2 gene promoter:
         Sp1   AP-1   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNQO2 promoter sequence
   Search Chromatin IP Primers for NQO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NQO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

NQO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NQO2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P003006:  view genomic region     (about GC identifiers)

Start:
2,988,221 bp from pter      End:
3,019,996 bp from pter
Size:
31,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083 (See protein sequence)
Recommended Name: Ribosyldihydronicotinamide dehydrogenase [quinone]  
Size: 231 amino acids; 25919 Da
Cofactor: Binds 1 zinc ion per subunit
Cofactor: FAD
Subunit: Homodimer
Miscellaneous: Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor
Selected PDB 3D structures from and Proteopedia for NQO2 (see all 45):
1QR2 (3D)        1SG0 (3D)        1XI2 (3D)        1ZX1 (3D)        2BZS (3D)        2QMY (3D)    
Secondary accessions: B2R492 Q5TD04

Explore the universe of human proteins at neXtProt for NQO2: NX_P16083

Explore proteomics data for NQO2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16
  • Modification sites at PhosphoSitePlus

  • See NQO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000895.2  NP_001277150.1  NP_001277151.1  

    ENSEMBL proteins: 
     ENSP00000406951   ENSP00000369839   ENSP00000380829   ENSP00000337773   ENSP00000369806  
     ENSP00000369822   ENSP00000369821   ENSP00000369795   ENSP00000475864  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003680 Flavodoxin_fold

    Graphical View of Domain Structure for InterPro Entry P16083

    ProtoNet protein and cluster: P16083

    1 Blocks protein domain: IPB003680 NAD(P)H dehydrogenase (quinone)

    UniProtKB/Swiss-Prot: NQO2_HUMAN, P16083
    Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family


    NQO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NQO2_HUMAN, P16083
    Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of
    hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin
    K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis
    Catalytic activity: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone =
    1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
    Enzyme regulation: Inhibited by melatonin, resveratrol and 5-hydroxytryptamine
    Biophysicochemical properties: Kinetic parameters: KM=28 uM for NRH; KM=11.6 uM for menadione; KM=252 uM for NADH;

         Enzyme Number (IUBMB): EC 1.10.99.21

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001512dihydronicotinamide riboside quinone reductase activity IEA--
    GO:0008753NADPH dehydrogenase (quinone) activity TAS1691923
    GO:0009055electron carrier activity TAS1691923
    GO:0016491oxidoreductase activity ----
    GO:0046872metal ion binding IEA--
         
    NQO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NQO2:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nqo2):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  integument 
     tumorigenesis 

    NQO2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NQO2: Nqo2tm1Akj Nqo2tm1Bout

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NQO2
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    miRTarBase miRNAs that target NQO2:
    hsa-mir-320a (MIRT044829)

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    1 qRT-PCR Assays for microRNA that regulate NQO2:
    hsa-miR-590-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NQO2_HUMAN, P16083: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    NQO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NQO2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NQO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NQO2 (P160832, 3 ENSP000003377734) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELBQ012012, 3MINT-49032 I2D: score=2 
    RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    GORASP2Q9H8Y83, ENSP000002341604I2D: score=4 STRING: ENSP00000234160
    MAGEA11P433643I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007613memory IEA--

    NQO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NQO2

    7 HMDB Compounds for NQO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideReduced nicotinamide riboside (see all 3)----
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydroquinone1,4-Benzenediol (see all 35)123-31-9--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Nicotinamide riboside1-b-D-ribosyl-3-Pyridinecarboxamide (see all 12)1341-23-7--
    Quinone1,4-Benzoquine (see all 25)106-51-4--

    Selected DrugBank Compounds for NQO2 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5target--15078100 12351651 16765324 15733542 10433694
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423
    NADHbeta-DPNH (see all 18)606-68-8target--17031400 16905546
    Resveratrol(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol (see all 9)501-36-0target--15350128 15381063
    (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione-- --target--10592235
    10-Propargyl-5,8-Dideazafolic Acid-- --target--10592235
    5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one-- --target--10592235
    6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one-- --target--10592235
    CB1954-- --target--10592235
    Dabigatran etexilateDabigatran (see all 2)211915-06-9enzymeinhibitor22494098

    Selected Novoseek inferred chemical compound relationships for NQO2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    quinone 91.6 99 18579530 (7), 15733542 (5), 15350128 (3), 18254726 (3) (see all 52)
    cb1954 87.4 6 16129418 (2), 18062662 (2), 9367528 (1)
    menadione 75.7 7 18374191 (1), 15733542 (1), 1691923 (1), 18254726 (1) (see all 6)
    melatonin 68.7 46 18254726 (5), 17910598 (4), 16293234 (3), 18502195 (2) (see all 14)
    2[125i]iodomelatonin 68.1 3 18254726 (1)
    dicoumarol 63 3 11154737 (1), 9367528 (1)
    tbhq 57.6 3 16545679 (2)
    resveratrol 54.8 30 18671725 (7), 15350128 (5), 15993843 (3), 19767760 (2)
    beta-naphthoflavone 45 2 8182056 (1)
    nadph 44.5 6 11154737 (1), 18538895 (1), 9050836 (1), 17031400 (1) (see all 6)



    NQO2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NQO2 gene (3 alternative transcripts): 
    NM_000904.4  NM_001290221.1  NM_001290222.1  

    Unigene Clusters for NQO2:

    NAD(P)H dehydrogenase, quinone 2
    Hs.145597  [show with all ESTs], Hs.533050  [show with all ESTs]
    Unigene Representative Sequences: AK097187, AK056981
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426637 ENST00000380472(uc003mup.1) ENST00000397717 ENST00000338130(uc003mus.2 uc003mut.2)
    ENST00000380441 ENST00000380455 ENST00000380454 ENST00000380430 ENST00000606474


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    Additional mRNA sequence: 

    AK056981.1 AK311746.1 BC006096.2 J02888.1 

    17 DOTS entries:

    DT.452875  DT.100797292  DT.100017506  DT.65284171  DT.97847745  DT.95173411  DT.100797286  DT.102827444 
    DT.121352982  DT.216153  DT.100683819  DT.92426442  DT.92426448  DT.98083451  DT.99997381  DT.65284170 
    DT.91654768 

    Selected AceView cDNA sequences (see all 260):

    CA310341 CK300956 CA308279 CR600371 BQ184931 BQ025114 AK056981 CD366005 
    BX280672 BF689694 BQ226005 BM683688 CN479098 AI492470 BM984758 BU607941 
    AW005149 BQ185566 CD369046 BU626474 BM683654 BM798996 BM824959 AI216650 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NQO2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                    -                 -                                                                     
    SP2:                    -     -     -     -     -                                                               
    SP3:                    -     -     -     -     -                                   -     -                     
    SP4:                          -     -     -     -                                                               
    SP5:                    -     -     -     -     -           -     -                                             


    ECgene alternative splicing isoforms for NQO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NQO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGACTTT
    NQO2 Expression
    About this image


    NQO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebellum
     
     Adipose (Muscoskeletal System)
     
     Adrenal Gland (Endocrine System)
    NQO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NQO2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.145597 Hs.533050
        Pathway & Disease-focused RT2 Profiler PCR Array including NQO2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NQO2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nqo21 , 5 NAD(P)H dehydrogenase, quinone 21, 5 82.68(n)1
    81.66(a)1
      13 (14.01 cM)5
    181051  NM_020282.31  NP_064678.11 
     339646595 
    chicken
    (Gallus gallus)
    Aves NQO21 NAD(P)H dehydrogenase, quinone 2 71.62(n)
    71.18(a)
      420886  XM_418973.4  XP_418973.1 
    lizard
    (Anolis carolinensis)
    Reptilia NQO26
    NAD(P)H dehydrogenase, quinone 2
    64(a)
    1 ↔ 1
    GL343247.1(945456-950375)


    ENSEMBL Gene Tree for NQO2 (if available)
    TreeFam Gene Tree for NQO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NQO2 gene
    NQO12  
    1 SIMAP similar gene for NQO2 using alignment to 5 protein entries:     NQO2_HUMAN (see all proteins):
    NQO1

    NQO2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NQO2
    PGOHUM00000243468


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NQO2 (see all 665)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77467241,2
    C,F--2998075(+) CTTTAT/CGTTAT 1 -- us2k15Minor allele frequency- C:0.18WA CSA NA 244
    rs1119739551,2
    C,F--2998116(+) GATGCT/GGGTAG 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs77601371,2
    C,F,A,H--2998124(+) TAGCAG/CAAGGG 1 -- us2k1 trp311Minor allele frequency- C:0.46NA WA CSA EA 374
    rs77428131,2
    C,F,A,H--2998164(+) CAATGA/TCCTCT 1 -- us2k111Minor allele frequency- T:0.40NA WA CSA EA 374
    rs77603271,2
    C--2998248(+) GGGGCG/TTTGGG 1 -- us2k10--------
    rs65969271,2
    C,F,A,H--2998319(+) CTTGCA/TTTCCA 1 -- us2k14Minor allele frequency- T:0.38WA NA 8
    rs65969281,2
    C,F,A,H--2998349(+) GAAAAG/TTGAGA 1 -- us2k15Minor allele frequency- T:0.13NA WA 244
    rs1403879341,2
    --2998384(+) TTTGTC/TGTTGG 1 -- us2k10--------
    rs1142094581,2
    C,F--2998416(+) GTAGCA/C/GTGACC 1 -- us2k11NA 120
    rs1448298241,2
    --2998452(+) ATGGTC/TAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NQO2 (2988221 - 3019996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NQO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5177CNV Insertion18451855
    nsv883401CNV Loss21882294
    nsv523441CNV Loss19592680
    dgv6429n71CNV Loss21882294
    nsv883398CNV Loss21882294
    nsv883402CNV Loss21882294
    nsv830575CNV Loss17160897
    nsv470795CNV Gain18288195
    dgv1900e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NQO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NQO2
    DNA2.0 Custom Variant and Variant Library Synthesis for NQO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160998   
    OMIM disorders: 114480  
    Selected diseases for NQO2 (see all 28):    
    About MalaCards
    brca1 and brca2 hereditary breast and ovarian cancer    alcoholic pancreatitis    brca2 hereditary breast and ovarian cancer    hereditary breast ovarian cancer
    substance dependence    hepatoblastoma    rubella    parkinson's disease
    schizophrenia    myelodysplastic syndromes    herpes simplex    acute myeloid leukemia
    breast cancer    influenza    esophageal cancer    pancreatitis
    melanoma    myeloid leukemia    pancreatic cancer    ovarian cancer


    NQO2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for NQO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 48.9 4 1691923 (1), 8182056 (1)
    agranulocytosis 32.1 1 14617031 (1)
    parkinson disease 30 6 18314446 (2), 11688992 (1), 15451063 (1), 18579530 (1) (see all 5)
    cancer 13 6 10945627 (1), 16129418 (1), 17643990 (1), 18062662 (1)
    melanoma 9.46 2 15993843 (2)
    schizophrenia 8.78 6 14639047 (4), 16955993 (1)
    tumors 0.903 7 18794327 (3), 14529407 (2), 11809856 (1), 16955993 (1)

    Genetic Association Database (GAD): NQO2
    Human Genome Epidemiology (HuGE) Navigator: NQO2 (20 documents)

    Export disorders for NQO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NQO2 gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with NQO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of quinone reductase 2 in complex with resveratrol. (PubMed id 15350128)1, 2, 7, 9 Buryanovskyy L....Zhang Z. (Biochemistry 2004)
    2. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. (PubMed id 1691923)1, 2, 3, 9 Jaiswal A.K.... McBride O.W. (Biochemistry 1990)
    3. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. (PubMed id 15078100)1, 2, 7, 9 Kwiek J.J.... Rudolph J. (Biochemistry 2004)
    4. Crystal structure of human quinone reductase type 2, a metalloflavoprotein. (PubMed id 10433694)1, 2, 7, 9 Foster C.E.... Amzel L.M. (Biochemistry 1999)
    5. Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase. (PubMed id 9367528)1, 2, 9 Wu K.... Chen S. (Arch. Biochem. Biophys. 1997)
    6. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. (PubMed id 18254726)1, 2, 9 Calamini B.... Mesecar A.D. (Biochem. J. 2008)
    7. Human NAD(P)H:quinone oxidoreductase 2. Gene structure, activity, and tissue-specific expression. (PubMed id 8182056)1, 2, 9 Jaiswal A.K. (J. Biol. Chem. 1994)
    8. Quinone reductase 2 is a catechol quinone reductase. (PubMed id 18579530)1, 2, 9 Fu Y.... Zhang Z. (J. Biol. Chem. 2008)
    9. A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia. (PubMed id 14639047)1, 4, 9 Harada S....Kawanishi Y. (Psychiatr. Genet. 2003)
    10. Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms. (PubMed id 12960511)1, 4, 9 Okubo T....Matsushita S. (Alcohol. Clin. Exp. Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4835 HGNC: 7856 AceView: NQO2andDKFZp686I15217 Ensembl:ENSG00000124588 euGenes: HUgn4835
    ECgene: NQO2 H-InvDB: NQO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NQO2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nqo2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NQO2 gene:
    Search GeneIP for patents involving NQO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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