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Aliases for NQO1 Gene

Aliases for NQO1 Gene

  • NAD(P)H Quinone Dehydrogenase 1 2 3
  • NAD(P)H Dehydrogenase, Quinone 1 2 3 5
  • Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase) 2 3
  • NAD(P)H:Quinone Oxidoreductase 1 3 4
  • Phylloquinone Reductase 3 4
  • Menadione Reductase 3 4
  • Quinone Reductase 1 3 4
  • DT-Diaphorase 3 4
  • Azoreductase 3 4
  • EC 1.6.5.2 4 63
  • NMOR1 3 4
  • DIA4 3 4
  • DTD 3 4
  • QR1 3 4
  • NAD(P)H:Quinone Acceptor Oxidoreductase Type 1 3
  • NAD(P)H:Menadione Oxidoreductase 1 3
  • NAD(P)H:Quinone Oxireductase 3
  • Dioxin-Inducible 1 3
  • Diaphorase-4 3
  • NMORI 3
  • DHQU 3

External Ids for NQO1 Gene

Previous HGNC Symbols for NQO1 Gene

  • NMOR1
  • DIA4

Previous GeneCards Identifiers for NQO1 Gene

  • GC16M060424
  • GC16M070163
  • GC16M069478
  • GC16M069519
  • GC16M068300
  • GC16M069744
  • GC16M055621

Summaries for NQO1 Gene

Entrez Gene Summary for NQO1 Gene

  • This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NQO1 Gene

NQO1 (NAD(P)H Quinone Dehydrogenase 1) is a Protein Coding gene. Diseases associated with NQO1 include tardive dyskinesia and anal canal carcinoma. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and oxidoreductase activity. An important paralog of this gene is NQO2.

UniProtKB/Swiss-Prot for NQO1 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Gene Wiki entry for NQO1 Gene

PharmGKB "VIP" Summary for NQO1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NQO1 Gene

Genomics for NQO1 Gene

Regulatory Elements for NQO1 Gene

Promoters for NQO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NQO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NQO1 Gene

Chromosome:
16
Start:
69,706,996 bp from pter
End:
69,726,951 bp from pter
Size:
19,956 bases
Orientation:
Minus strand

Genomic View for NQO1 Gene

Genes around NQO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NQO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NQO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO1 Gene

Proteins for NQO1 Gene

  • Protein details for NQO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15559-NQO1_HUMAN
    Recommended name:
    NAD(P)H dehydrogenase [quinone] 1
    Protein Accession:
    P15559
    Secondary Accessions:
    • B2R5Y9
    • B4DNM7
    • B7ZAD1
    • Q86UK1

    Protein attributes for NQO1 Gene

    Size:
    274 amino acids
    Molecular mass:
    30868 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.

    Three dimensional structures from OCA and Proteopedia for NQO1 Gene

    Alternative splice isoforms for NQO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NQO1 Gene

Proteomics data for NQO1 Gene at MOPED

Selected DME Specific Peptides for NQO1 Gene

Post-translational modifications for NQO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NQO1 (NQO1)

Domains & Families for NQO1 Gene

Protein Domains for NQO1 Gene

Graphical View of Domain Structure for InterPro Entry

P15559

UniProtKB/Swiss-Prot:

NQO1_HUMAN :
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.
genes like me logo Genes that share domains with NQO1: view

No data available for Gene Families for NQO1 Gene

Function for NQO1 Gene

Molecular function for NQO1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dicoumarol.
UniProtKB/Swiss-Prot Function:
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
UniProtKB/Swiss-Prot Induction:
By dioxin.

Enzyme Numbers (IUBMB) for NQO1 Gene

Gene Ontology (GO) - Molecular Function for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NQO1: view
genes like me logo Genes that share phenotypes with NQO1: view

Animal Models for NQO1 Gene

MGI Knock Outs for NQO1:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NQO1 Gene

Localization for NQO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NQO1 Gene COMPARTMENTS Subcellular localization image for NQO1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NQO1: view

Pathways & Interactions for NQO1 Gene

genes like me logo Genes that share pathways with NQO1: view

Gene Ontology (GO) - Biological Process for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006801 superoxide metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS 10393963
GO:0006979 response to oxidative stress IEA --
GO:0007271 synaptic transmission, cholinergic TAS 9579781
genes like me logo Genes that share ontologies with NQO1: view

No data available for SIGNOR curated interactions for NQO1 Gene

Drugs & Compounds for NQO1 Gene

(86) Drugs for NQO1 Gene - From: Novoseek, HMDB, FDA Approved Drugs, DrugBank, PharmGKB, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dicumarol Approved Pharma Target, inhibitor 0
Menadione Approved Nutra inhibitor, Target 199
FAD Approved Pharma Target 0
Vitamin E Approved Nutra Enzyme, inducer 371,376
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum 2540

(69) Additional Compounds for NQO1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
vitamin k1
  • 2',3'-trans-Vitamin K1
  • 2-Methyl-3-phythyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • 2-Methyl-3-phytyl-1,4-napthoquinone
12001-79-5
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Menaquinol

(2) ApexBio Compounds for NQO1 Gene

Compound Action Cas Number
Dicoumarol 66-76-2
DMXAA (Vadimezan) Tumnor vascular disrupting agent, apoptosis inducer 117570-53-3
genes like me logo Genes that share compounds with NQO1: view

Transcripts for NQO1 Gene

Unigene Clusters for NQO1 Gene

NAD(P)H dehydrogenase, quinone 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1:
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8: - - - - -
SP9: - - - - -

Relevant External Links for NQO1 Gene

GeneLoc Exon Structure for
NQO1
ECgene alternative splicing isoforms for
NQO1

Expression for NQO1 Gene

mRNA expression in normal human tissues for NQO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO1 Gene

This gene is overexpressed in Stomach (x5.2).

Protein differential expression in normal tissues from HIPED for NQO1 Gene

This gene is overexpressed in Nasopharynx (13.6), Skin (8.6), and Nasal epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NQO1 Gene



SOURCE GeneReport for Unigene cluster for NQO1 Gene Hs.406515

genes like me logo Genes that share expression patterns with NQO1: view

Protein tissue co-expression partners for NQO1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NQO1 Gene

Orthologs for NQO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NQO1 35
  • 91.24 (n)
  • 90.88 (a)
NQO1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NQO1 35
  • 85.59 (n)
  • 87.55 (a)
NQO1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo1 35
  • 85.89 (n)
  • 86.5 (a)
Nqo1 16
Nqo1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NQO1 35
  • 99.58 (n)
  • 99.58 (a)
NQO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nqo1 35
  • 85.04 (n)
  • 85.4 (a)
oppossum
(Monodelphis domestica)
Mammalia NQO1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NQO1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NQO1 35
  • 61.68 (n)
  • 60.58 (a)
NQO1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nqo1 35
  • 66.79 (n)
  • 63.24 (a)
zebrafish
(Danio rerio)
Actinopterygii nqo1 35
  • 58.27 (n)
  • 49.64 (a)
nqo1 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8645 35
Species with no ortholog for NQO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NQO1 Gene

ENSEMBL:
Gene Tree for NQO1 (if available)
TreeFam:
Gene Tree for NQO1 (if available)

Paralogs for NQO1 Gene

Paralogs for NQO1 Gene

(1) SIMAP similar genes for NQO1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NQO1: view

Variants for NQO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NQO1 Gene

P15559-NQO1_HUMAN
The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.

Sequence variations from dbSNP and Humsavar for NQO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1800566 - 69,711,242(-) TAGAA(C/T)CTCAA reference, missense
rs1131341 - 69,714,966(-) CCTTC(C/G/T)GGGTA intron-variant, reference, missense
rs34447156 - 69,710,994(+) TTGAT(C/G)TGGTT reference, missense
rs10517 -- 69,709,857(-) CTTAC(C/T)ATGGG utr-variant-3-prime
rs689452 -- 69,718,561(-) TTTCC(C/G/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NQO1 Gene

Variant ID Type Subtype PubMed ID
nsv906822 CNV Gain 21882294
nsv906823 CNV Gain 21882294
nsv517207 CNV Loss 19592680
nsv524364 CNV Loss 19592680

Variation tolerance for NQO1 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.04; 92.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NQO1 Gene

HapMap Linkage Disequilibrium report
NQO1
Human Gene Mutation Database (HGMD)
NQO1

Disorders for NQO1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for NQO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tardive dyskinesia
  • lingual-facial-buccal dyskinesia
anal canal carcinoma
  • anal canal and perianal gland carcinoma
colon adenocarcinoma
  • adenocarcinoma of colon
childhood leukemia
alcoholic pancreatitis
  • pancreatitis alcoholic
- elite association - COSMIC cancer census association via MalaCards
Search NQO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NQO1

Genetic Association Database (GAD)
NQO1
Human Genome Epidemiology (HuGE) Navigator
NQO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NQO1
genes like me logo Genes that share disorders with NQO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NQO1 Gene

Publications for NQO1 Gene

  1. No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. (PMID: 10447260) Kristiansen O.P. … Pociot F. (Hum. Mutat. 1999) 3 4 48 67
  2. Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. (PMID: 10419545) Chen S. … Yang C.S. (Mol. Pharmacol. 1999) 23 25 26
  3. DT-diaphorase protects against menadione-induced oxidative stress. (PMID: 10614691) Chiou T.J. … Tzeng W.F. (Toxicology 1999) 23 25 26
  4. Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition. (PMID: 2113031) Preusch P.C. … Smalley D.M. (Free Radic. Res. Commun. 1990) 23 25 26
  5. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. (PMID: 19593802) Silveira V.d.a. .S. … Tone L.G. (Environ. Mol. Mutagen. 2010) 3 23

Products for NQO1 Gene

Sources for NQO1 Gene

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