Aliases for NQO1 Gene
External Ids for NQO1 Gene
Previous Symbols for NQO1 Gene
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for NQO1 Gene
NQO1 (NAD(P)H Dehydrogenase, Quinone 1) is a Protein Coding gene. Diseases associated with NQO1 include tardive dyskinesia and atrophy of testis. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include cytochrome-b5 reductase activity, acting on NAD(P)H and NAD(P)H dehydrogenase (quinone) activity. An important paralog of this gene is NQO2.
UniProtKB/Swiss-Prot for NQO1 Gene
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis