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Aliases for NQO1 Gene

Aliases for NQO1 Gene

  • NAD(P)H Dehydrogenase, Quinone 1 2 3
  • NMOR1 3 4 6
  • DIA4 3 4 6
  • Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase) 2 3
  • NAD(P)H:Quinone Oxidoreductase 1 3 4
  • Phylloquinone Reductase 3 4
  • Menadione Reductase 3 4
  • Quinone Reductase 1 3 4
  • DT-Diaphorase 3 4
  • Azoreductase 3 4
  • EC 1.6.5.2 4 63
  • DTD 3 4
  • QR1 3 4
  • NAD(P)H:Quinone Acceptor Oxidoreductase Type 1 3
  • NAD(P)H:Menadione Oxidoreductase 1 3
  • NAD(P)H Dehydrogenase [Quinone] 1 3
  • NAD(P)H:Quinone Oxireductase 3
  • Dioxin-Inducible 1 3
  • Diaphorase-4 3
  • NMORI 3
  • DHQU 3

External Ids for NQO1 Gene

Previous Symbols for NQO1 Gene

  • NMOR1
  • DIA4

Summaries for NQO1 Gene

Entrez Gene Summary for NQO1 Gene

  • This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NQO1 Gene

NQO1 (NAD(P)H Dehydrogenase, Quinone 1) is a Protein Coding gene. Diseases associated with NQO1 include tardive dyskinesia and atrophy of testis. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include cytochrome-b5 reductase activity, acting on NAD(P)H and NAD(P)H dehydrogenase (quinone) activity. An important paralog of this gene is NQO2.

UniProtKB/Swiss-Prot for NQO1 Gene

  • The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO1 Gene

PharmGKB "VIP" Summary for NQO1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NQO1 Gene

Genomics for NQO1 Gene

Genomic Location for NQO1 Gene

Start:
69,706,996 bp from pter
End:
69,726,951 bp from pter
Size:
19,956 bases
Orientation:
Minus strand

Genomic View for NQO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NQO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NQO1 Gene

Regulatory Elements for NQO1 Gene

Proteins for NQO1 Gene

  • Protein details for NQO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15559-NQO1_HUMAN
    Recommended name:
    NAD(P)H dehydrogenase [quinone] 1
    Protein Accession:
    P15559
    Secondary Accessions:
    • B2R5Y9
    • B4DNM7
    • B7ZAD1
    • Q86UK1

    Protein attributes for NQO1 Gene

    Size:
    274 amino acids
    Molecular mass:
    30868 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency

    Three dimensional structures from OCA and Proteopedia for NQO1 Gene

    Alternative splice isoforms for NQO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NQO1 Gene

Proteomics data for NQO1 Gene at MOPED

Selected DME Specific Peptides for NQO1 Gene

Post-translational modifications for NQO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NQO1 Gene

Domains for NQO1 Gene

Protein Domains for NQO1 Gene

Graphical View of Domain Structure for InterPro Entry

P15559

UniProtKB/Swiss-Prot:

NQO1_HUMAN
Family:
  • Belongs to the NAD(P)H dehydrogenase (quinone) family.:
    • P15559
genes like me logo Genes that share domains with NQO1: view

No data available for Gene Families for NQO1 Gene

Function for NQO1 Gene

Molecular function for NQO1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by dicoumarol
UniProtKB/Swiss-Prot Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis
UniProtKB/Swiss-Prot Induction: By dioxin

Enzyme Numbers (IUBMB) for NQO1 Gene

Gene Ontology (GO) - Molecular Function for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003955 NAD(P)H dehydrogenase (quinone) activity IEA --
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS 9579781
GO:0004784 superoxide dismutase activity IEA --
GO:0005515 protein binding IPI 18388957
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with NQO1: view
genes like me logo Genes that share phenotypes with NQO1: view

Animal Models for NQO1 Gene

MGI Knock Outs for NQO1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for NQO1 Gene

Localization for NQO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NQO1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NQO1 Gene COMPARTMENTS Subcellular localization image for NQO1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NQO1: view

Pathways for NQO1 Gene

genes like me logo Genes that share pathways with NQO1: view

Gene Ontology (GO) - Biological Process for NQO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006801 superoxide metabolic process --
GO:0006805 xenobiotic metabolic process TAS 10393963
GO:0006809 nitric oxide biosynthetic process TAS 9579781
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with NQO1: view

Compounds for NQO1 Gene

(10) HMDB Compounds for NQO1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Hydroquinone
  • 1,4-Benzenediol
123-31-9
Menadione
  • Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene
58-27-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4

(130) Novoseek inferred chemical compound relationships for NQO1 Gene

Compound -log(P) Hits PubMed IDs
dicoumarol 95.1 128
medzq 92.6 21
5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione 90.9 8
quinone 90.9 131
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone 90.8 7

(6) PharmGKB related drug/compound annotations for NQO1 Gene

Drug/compound Annotation
cisplatin CA
cyclophosphamide CA
doxorubicin CA
epirubicin CA
fluorouracil CA
warfarin CA
genes like me logo Genes that share compounds with NQO1: view

Transcripts for NQO1 Gene

Unigene Clusters for NQO1 Gene

NAD(P)H dehydrogenase, quinone 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1:
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8: - - - - -
SP9: - - - - -

Relevant External Links for NQO1 Gene

GeneLoc Exon Structure for
NQO1
ECgene alternative splicing isoforms for
NQO1

Expression for NQO1 Gene

mRNA expression in normal human tissues for NQO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NQO1 Gene

This gene is overexpressed in Stomach (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NQO1 Gene

SOURCE GeneReport for Unigene cluster for NQO1 Gene Hs.406515

genes like me logo Genes that share expressions with NQO1: view

No data available for mRNA Expression by UniProt/SwissProt for NQO1 Gene

Orthologs for NQO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NQO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NQO1 35
  • 99.58 (n)
  • 99.58 (a)
NQO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NQO1 35
  • 91.24 (n)
  • 90.88 (a)
NQO1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NQO1 35
  • 85.59 (n)
  • 87.55 (a)
NQO1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nqo1 35
  • 85.89 (n)
  • 86.5 (a)
Nqo1 16
Nqo1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NQO1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NQO1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nqo1 35
  • 85.04 (n)
  • 85.4 (a)
chicken
(Gallus gallus)
Aves NQO1 35
  • 61.68 (n)
  • 60.58 (a)
NQO1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NQO1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nqo1 35
  • 66.79 (n)
  • 63.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8645 35
zebrafish
(Danio rerio)
Actinopterygii nqo1 35
  • 58.27 (n)
  • 49.64 (a)
nqo1 36
  • 45 (a)
OneToOne
Species with no ortholog for NQO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NQO1 Gene

ENSEMBL:
Gene Tree for NQO1 (if available)
TreeFam:
Gene Tree for NQO1 (if available)

Paralogs for NQO1 Gene

Paralogs for NQO1 Gene

Selected SIMAP similar genes for NQO1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NQO1: view

Variants for NQO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NQO1 Gene

P15559-NQO1_HUMAN
The Ser-187 polymorphism may be linked to susceptibility to forms of cancers

Sequence variations from dbSNP and Humsavar for NQO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10517 -- 69,709,857(-) CTTAC(C/T)ATGGG utr-variant-3-prime
rs689452 -- 69,718,561(-) TTTCC(C/G)TGTGT intron-variant
rs689453 -- 69,718,470(-) AAGGA(A/G)GCTGC synonymous-codon, reference
rs689454 -- 69,727,830(-) GTCAC(A/G)ATGGg upstream-variant-2KB
rs689455 -- 69,727,758(-) ACCTG(A/C)GGTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NQO1 Gene

Variant ID Type Subtype PubMed ID
nsv906822 CNV Gain 21882294
nsv906823 CNV Gain 21882294
nsv517207 CNV Loss 19592680
nsv524364 CNV Loss 19592680

Relevant External Links for NQO1 Gene

HapMap Linkage Disequilibrium report
NQO1
Human Gene Mutation Database (HGMD)
NQO1

Disorders for NQO1 Gene

(2) University of Copenhagen DISEASES for NQO1 Gene

(71) Novoseek inferred disease relationships for NQO1 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 61.9 23
cancer 54.3 74
nsclc 45.4 38
colon adenocarcinoma 44.8 8
lymphoblastic leukemia acute childhood 44.3 4

Relevant External Links for NQO1

Genetic Association Database (GAD)
NQO1
Human Genome Epidemiology (HuGE) Navigator
NQO1
genes like me logo Genes that share disorders with NQO1: view

No data available for UniProtKB/Swiss-Prot for NQO1 Gene

Publications for NQO1 Gene

  1. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT- diaphorase activity and mitomycin sensitivity. (PMID: 1737339) Traver R.D. … Gibson N.W. (Cancer Res. 1992) 3 4 23
  2. Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. (PMID: 1657151) Jaiswal A.K. (Biochemistry 1991) 3 4 23
  3. Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. (PMID: 10706635) Faig M. … Amzel L.M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  4. Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). (PMID: 10543876) Skelly J.V. … Neidle S. (J. Med. Chem. 1999) 3 4 23
  5. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. (PMID: 11051261) Naoe T. … Ohno R. (Clin. Cancer Res. 2000) 3 23 48

Products for NQO1 Gene

Sources for NQO1 Gene

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