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NQO1 Gene

protein-coding GIFtS: 69

GC16M068300

NAD(P)H dehydrogenase, quinone 1
(Previous name: diaphorase (NADH/NADPH) (cytochrome b-5 reductase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: NMOR1, DIA4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Azoreductase ^³
DHQU ^¹, ²
DIA4 ^², ³, ⁵
DT-diaphorase ^², ³
DTD ^¹, ², ³
EC 1.6.5.2 ^³
NMOR1 ^², ³, ⁵
NMORI ^²
QR1 ^¹, ², ³
azoreductase ^²
diaphorase-4 ^²

Descriptions
Menadione reductase ^², ³
NAD(P)H dehydrogenase, quinone 1 ^²
NAD(P)H menadione oxidoreductase 1, dioxin-inducible ^²
NAD(P)H:Quinone acceptor oxidoreductase type 1 ^²
NAD(P)H:menadione oxidoreductase 1 ^²
NAD(P)H:quinone oxidoreductase 1 ^³
NAD(P)H:quinone oxireductase ^²
Phylloquinone reductase ^², ³
Quinone reductase 1 ^², ³
diaphorase (NADH/NADPH) (cytochrome b-5 reductase) ^¹, ²
dioxin-inducible 1 ^²

External Ids
HGNC: 2874¹
Entrez Gene: 1728²
UniProtKB: P15559³
Ensembl: ENSG00000181019⁷

Search outside databases for aliases for NQO1 gene

Previous GC identifers: GC16M060424 GC16M070163 GC16M069478 GC16M069519

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NQO1:

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic

2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to

hydroquinones. This protein's enzymatic activity prevents the one electron reduction of

quinones that results in the production of radical species. Mutations in this gene have been

associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to

benzene, and susceptibility to various forms of cancer. Altered expression of this protein has

been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate

transcriptional splice variants, encoding different isoforms, have been characterized. [provided

by RefSeq]

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation

reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes

such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO1 (NAD(P)H_dehydrogenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NQO1 gene

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q12-q22

NQO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M068300: (about GC identifiers)

Start:	68,300,805 bp from pter
End:	68,318,034 bp from pter
Size:	17,230 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559 (See protein sequence)

Recommended Name: NAD(P)H dehydrogenase [quinone] 1

Size: 274 amino acids; 30868 Da

Cofactor: FAD

Subunit: Homodimer

Subcellular location: Cytoplasm

Mass spectrometry: Mass=30864; Mass_error=6; Method=Electrospray; Range=1-274;

Source=PubMed:11735396;

Miscellaneous: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency

PDB structures from and Proteopedia :

1D4A (3D)

1DXO (3D)

1GG5 (3D)

1H66 (3D)

1H69 (3D)

1KBO (3D)

1KBQ (3D)

1QBG (3D)

2F1O (3D)

Secondary accessions: Q86UK1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000894.1 NP_001020604.1 NP_001020605.1

ENSEMBL proteins:

ENSP00000319788 ENSP00000368335 ENSP00000368334

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for NQO1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NQO1)
	Human Recombinant Proteins from Abnova (NQO1)

OriGene Purified Recombinant Human Protein: NQO1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	2843525

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Antibodies for NQO1:

	Invitrogen Antibodies for NQO1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NQO1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NQO1
	Antibodies from Abcam (NQO1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NQO1)
	Novus Biologicals Antibodies for NQO1

Assays for NQO1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P15559

ProtoNet protein and cluster: P15559

1 Blocks protein family: IPB003680 NAD(P)H dehydrogenase (quinone)

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NQO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NQO1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000903

Applied Biosystems Silencer® siRNAs for NQO1

Sigma-Aldrich siRNA for NQO1

Sigma-Aldrich shRNA for NQO1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NQO1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000903
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000903
untagged cDNA clones in CMV expression vector (see all 5): BC000906

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000903

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation

reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes

such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis

Catalytic activity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone

Enzyme regulation: Inhibited by dicoumarol

Induction: By dioxin

Enzyme Number (IUBMB): EC 1.6.5.2

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nqo1):

adipose tissue	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	skin/coat/nails	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	TAS	10393963
GO:0004128	cytochrome-b5 reductase activity	TAS	9579781
GO:0009055	electron carrier activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0050662	coenzyme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for NQO1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Xenobiotic Metabolism Signaling
NRF2-mediated Oxidative Stress Response
Biosynthesis of Steroids
Aminosugars Metabolism
Hypoxia Signaling in the Cardiovascular System

GeneDecks NQO1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for NQO1

5/52 Interacting proteins for NQO1 (ENSP00000319788³ P15559²) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ING1	Q9UK53²	MINT-6616064 MINT-6616019 MINT-6616047
KEAP1	ENSP00000171111³	STRING (score=.986)
TP53	ENSP00000269305³	STRING (score=.977)
CYP1A1	ENSP00000369050³	STRING (score=.967)
ODC1	ENSP00000234111³	STRING (score=.962)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	10393963
GO:0006809	nitric oxide biosynthetic process	TAS	9579781
GO:0007271	synaptic transmission, cholinergic	TAS	9579781
GO:0009636	response to toxin	TAS	10393963
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for NQO1:

Inhibitor

Browse Tocris compounds for NQO1
10/44 Novoseek chemical compound relationships for NQO1 gene (see all 44 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
medzq	92.94	29	9865924 (4), 7565631 (3), 1406604 (2), 8137269 (2) (see all 12)
5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione	91.34	10	11735396 (1), 15102952 (1), 16891456 (1), 11377380 (1) (see all 8)
quinone	91.12	210	8657209 (4), 11862423 (4), 7780966 (3), 8653808 (3) (see all 99)
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	90.56	7	18794327 (1), 15940348 (1), 17015278 (1), 11377380 (1) (see all 6)
cb1954	86.14	9	8205540 (1), 10543876 (1), 8373433 (1), 1385952 (1) (see all 6)
beta-lapachone	85.12	70	10681517 (4), 15837761 (4), 18283592 (4), 16361576 (3) (see all 19)
2,6-dichlorophenolindophenol	79.33	19	7779711 (1), 2113031 (1), 8373161 (1), 8205540 (1) (see all 12)
nadph	77.79	114	18848878 (8), 8593536 (5), 15102952 (2), 11862423 (2) (see all 72)
2-amino-1,4-naphthoquinone	74.92	4	16045903 (3), 11697195 (1)
nadh	69.97	50	18848878 (7), 15102952 (2), 8082230 (2), 8264549 (2) (see all 26)

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6 PharmGKB drug compound relationships for NQO1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
anthracycline	CO GN	12439220
benzene	CO PK	9230185
etoposide	CO GN	11840286 12439220
mitomycin c	CO	11773862
vitamin k	PD	9825838
xenobiotics	FA GN	12172217 10208650

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NQO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NQO1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000903

Sigma-Aldrich siRNA for NQO1

Sigma-Aldrich shRNA for NQO1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000903 NM_001025433 NM_001025434

REFSEQ mRNAs for NQO1 gene (3 alternative transcripts):

NM_000903.2 NM_001025433.1 NM_001025434.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000903 NM_001025433 NM_001025434

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000903
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000903
                                 untagged cDNA clones in CMV expression vector (see all 5): BC000906

Additional cDNA sequence:

AK223050.1 AK297125.1 AK297979.1 AK298896.1 AK307533.1 AK309513.1 AK312368.1 AK316246.1

BC000906.2 BC007659.2 BC107739.1 CR623236.1 J03934.1

16 DOTS entries:

DT.100739730 DT.40222375 DT.95273877 DT.99982242 DT.120715278 DT.100031386 DT.91962533 DT.100853457

DT.100853467 DT.120715262 DT.92040555 DT.97855800 DT.120715271 DT.435292 DT.120715220 DT.120715052

24/672 AceView cDNA sequences (see all 672 ):

N47386 BU543105 BM826228 BU543786 CB118439 BU189113 D11593 BM990575

AI139093 CB110102 CF265064 BM716149 AI074406 AI922277 BM772299 BQ689406

CF529867 CD673718 BQ954230 AA295488 BM772380 BG212505 BM856772 CN482595

highest scoring ESTs for NQO1:

AA020909 AA055872 AA070398 AA149601 AA295231 AA295266 AA295488 AA302015 AA306417 AA308285

Unigene Cluster for NQO1:

NAD(P)H dehydrogenase, quinone 1

Hs.406515 [show with all ESTs]

Unigene Representative Sequence: NM_000903

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	^	7
SP1:
SP2:																	-		-		-														-
SP3:															-		-
SP4:																	-		-		-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for NQO1

3 Ensembl transcripts including schematic representations:

ENST00000320623 ENST00000379047 ENST00000379046

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NQO1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NQO1

¹ / ² / ³

7 probe-sets matching NQO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38066_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M81600	0.20	1.00	0.72	1
210519_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000906	0.80	1.00	0.91	1
201468_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000903	0.60	1.00	0.82	1
201467_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI039874	0.40	1.00	0.76	1
210519_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201468_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201467_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NQO1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTATCAAATC

SOURCE GeneReport for Unigene cluster: Hs.406515
Expression variation in blood from EXPOLDB for NQO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NQO1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NQO1¹	--	NAD(P)H dehydrogenase, quinone 1	85.85(n) 88.19(a)	610935 XM_848524.1 XP_853617.1
chimpanzee (Pan troglodytes)	NQO1¹	--	NAD(P)H dehydrogenase, quinone 1	99.52(n) 99.28(a)	468012 XM_523404.2 XP_523404.2
cow (Bos taurus)	NQO1¹	--	NAD(P)H dehydrogenase, quinone 1	91.24(n) 90.88(a)	519632 NM_001034535.1 NP_001029707.1
rat (Rattus norvegicus)	Nqo1¹	--	NAD(P)H dehydrogenase, quinone 1	85.04(n) 85.4(a)	24314 NM_017000.2 NP_058696.2
mouse (Mus musculus)	Nqo1^{1, 5}	8 (53.30 cM)⁵	NAD(P)H dehydrogenase, quinone 1^{1, 5}	85.89(n)¹ 86.5(a)¹	18104¹ NM_008706.3¹ NP_032732.3¹ AA982077⁵ AK075568⁵ (see all 13)

About this table Species with no ortholog for NQO1

ENSEMBL Gene Tree for NQO1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NQO1 gene

NQO2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Polymorphism: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers

10/129 NCBI SNPs in NQO1 are shown (see all 129 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1800566^1,2	A,C,F,H,O	68302646(-)	`TAGAAC/TCTCAA`	3	P/S	mis¹ ese³		30	MN CSAM EA NA EU WA NS	3550
	rs10517^1,2	A,C,F,H	68301261(-)	`CTTACC/TATGGG`	3	--	ut3¹ ese³		15	MN EU EA WA CSAM	1527
	rs689457^1,2	C,F,H	68318677(-)	`gtcCCG/ATTTTG`	3	--	ng3¹		9	NA EU EA WA	992
	rs689459^1,2	F,H	68318123(-)	`AGAGGC/GCCCTC`	3	--	ng3¹ trp³		5	NA EU EA WA	590
	rs689456^1,2	C,F	68319064(-)	`TCTGTA/GATTCT`	3	--	ng3¹		1	NA	126
	rs689458^1,2	F,H	68318561(-)	`CAGGGG/CTGGTG`	3	--	ng3¹		5	NA EU EA WA	578
--	rs34447156^1,2	C,F	68302398(+)	`TTGATC/GTGGTT`	3	Q/H	mis¹		5	NA EU EA WA	498
--	rs11555215^1,2	H	68306429(-)	`TGAGCG/CAGTGT`	3	P/R	mis¹ int¹		4	EU EA WA	406
--	rs689454^1,2	F	68319234(-)	`GTCACG/AATGGg`	3	--	ng3¹ tfbs³		1	NA	178
--	rs8056468^1,2	H	68301604(+)	`tgatgG/Acaggc`	3	--	ut3¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for NQO1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 125860

10/69 Novoseek disease relationships for NQO1 gene (see all 69 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	62.91	34	8615901 (2), 9865924 (2), 1737339 (2), 8205521 (1) (see all 20)
cancer	54.04	87	16361576 (3), 18283592 (3), 15877230 (2), 11693537 (2) (see all 54)
nsclc	47.33	69	1324793 (6), 9748120 (5), 12370763 (3), 9865924 (3) (see all 20)
adult brain tumor	46.97	2	16598069 (1), 17372252 (1)
colon adenocarcinoma	46.69	9	8180125 (2), 8653808 (2), 15896333 (1), 11377380 (1) (see all 6)
tumors	44.11	219	8375015 (6), 15877230 (5), 11350900 (5), 10845577 (4) (see all 99)
lymphoblastic leukemia acute childhood	43.82	3	11774269 (1), 18945694 (1), 18024413 (1)
hepatoblastoma	42.25	8	1691923 (1), 1651729 (1), 1657151 (1), 1899380 (1) (see all 7)
colon cancer	42.14	29	17164365 (5), 10391098 (2), 15877230 (1), 11894133 (1) (see all 11)
bladder cancer	40.65	19	12694753 (5), 12777965 (3), 15375541 (3), 14999778 (2) (see all 10)

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6 PharmGKB disease relationships for NQO1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Hematologic Neoplasms	CO PK	9230185
Leukemia, Lymphocytic, Acute, L1	CO GN	12439220
Leukemia, Myelocytic, Acute	CO GN	11840286
Leukemia, Myeloid	CO GN	12439220
Urinary Calculi	PD	9825838
peritoneal cancer	CO	11773862

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Human Gene Mutation Database: NQO1
Genetic Association Database: NQO1
Human Genome Epidemiology Navigator: NQO1 (204 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Genetic Polymorphisms in Xenobiotic-Metabolising Enzymes and Their Association With Colorectal Cancer: Presented at AACR-NCI-EORTC

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/766 PubMed articles for NQO1 gene (see all 766 ):

Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy. (PubMed id 11840286)^{1, 3, 6, 7} Naoe T....Ohno R. (2002)
Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C. (PubMed id 11773862)^{1, 3, 7} Fleming R.A....McQuellon R.P. (2002)
Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies. (PubMed id 12439220)^{3, 6, 7} Blanco J.G....Relling M.V. (2002)
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. (PubMed id 10447260)^{3, 4, 6} Kristiansen O.P.... Pociot F. (1999)
Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone. (PubMed id 9230185)^{1, 3, 7} Rothman N....Ross D. (1997)
Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. (PubMed id 2843525)^{2, 3, 4} Jaiswal A.K.... Nebert D.W. (1988)
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT- diaphorase activity and mitomycin sensitivity. (PubMed id 1737339)^{1, 3, 4} Traver R.D.... Gibson N.W. (1992)
An association between a NQO1 genetic polymorphism and risk of lung cancer. (PubMed id 15781212)^{1, 3, 6} Saldivar S.J....Wu X. (2005)
An association between NQO1 genetic polymorphism and risk of bladder cancer. (PubMed id 12694753)^{1, 3, 6} Park S.J....Wu X. (2003)
Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract. (PubMed id 14506737)^{1, 3, 6} Sarbia M....Gabbert H.E. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1728	HGNC: 2874	AceView: NQO1	Ensembl:ENSG00000181019	euGenes: HUgn1728
ECgene: NQO1	H-InvDB: NQO1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NQO1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/nqo1/

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NQO1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for NQO1

Summaries
for NQO1

Genomic Location
for NQO1

Proteins
for NQO1

Protein Domains/
Families
for NQO1

Gene Function
for NQO1

Pathways & Interactions
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Drugs & Compounds
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Transcripts
for NQO1

Expression
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NQO1 (Gene Symbol)
Azoreductase
DHQU
DIA4
DT-diaphorase
DTD
EC 1.6.5.2
NMOR1
NMORI
QR1
azoreductase
diaphorase-4
Menadione reductase
NAD(P)H dehydrogenase, quinone 1
NAD(P)H menadione oxidoreductase 1, dioxin-inducible
NAD(P)H:Quinone acceptor oxidoreductase type 1
NAD(P)H:menadione oxidoreductase 1
NAD(P)H:quinone oxidoreductase 1
NAD(P)H:quinone oxireductase
Phylloquinone reductase
Quinone reductase 1
diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
dioxin-inducible 1

NQO1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor NQO1

Summariesfor NQO1

Genomic Locationfor NQO1

Proteinsfor NQO1

Protein Domains/Familiesfor NQO1

Gene Functionfor NQO1

Pathways & Interactionsfor NQO1

Drugs & Compoundsfor NQO1

Transcriptsfor NQO1

Expression for NQO1

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Disorders & Mutationsfor NQO1

Medical Newsfor NQO1

Publicationsfor NQO1

Search for NQO1

Genome Databases showing NQO1

Other Databases showing NQO1

Specialized Databases showing NQO1

Licensable Technologiesfor NQO1

Servicesfor NQO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NQO1

Summaries
for NQO1

Genomic Location
for NQO1

Proteins
for NQO1

Protein Domains/
Families
for NQO1

Gene Function
for NQO1

Pathways & Interactions
for NQO1

Drugs & Compounds
for NQO1

Transcripts
for NQO1

Expression
for NQO1

Orthologs
for NQO1

Paralogs
for NQO1

SNPs/Variants
for NQO1

Disorders & Mutations
for NQO1

Medical News
for NQO1

Publications
for NQO1

Licensable Technologies
for NQO1

Services
for NQO1