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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NQO1 Gene

protein-coding GIFtS: 70
GCID: GC16M069744

NAD(P)H dehydrogenase, quinone 1

(Previous name: diaphorase (NADH/NADPH) (cytochrome b-5 reductase) )
(Previous symbols: NMOR1, DIA4)

Explore 116 diseases affiliated with
NQO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NAD(P)H Dehydrogenase, Quinone 1¹ ²		NAD(P)H:Quinone Oxidoreductase 1² ³
DIA4¹ ² ³ ⁵		EC 1.6.5.2³ ⁸
NMOR1¹ ² ³ ⁵		NMORI²
DTD¹ ² ³		Azoreductase³
QR1¹ ² ³		Diaphorase-4¹
DHQU¹ ²		Dioxin-Inducible 1²
Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase)¹ ²		NAD(P)H Dehydrogenase [Quinone] 1²
Menadione Reductase² ³		NAD(P)H:Menadione Oxidoreductase 1²
Phylloquinone Reductase² ³		NAD(P)H:Quinone Acceptor Oxidoreductase Type 1²
Quinone Reductase 1² ³		NAD(P)H:Quinone Oxireductase²
DT-Diaphorase¹		Azoreductase³

External Ids:	HGNC: 2874¹	Entrez Gene: 1728²	Ensembl: ENSG00000181019⁷	OMIM: 125860⁵	UniProtKB: P15559³

Export aliases for NQO1 gene to outside databases

Previous GC identifers: GC16M060424 GC16M070163 GC16M069478 GC16M069519 GC16M068300 GC16M055621

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NQO1:

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase.

This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity

prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this

gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene,

and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is

also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms,

have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons

involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent

gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO1 (NAD(P)H dehydrogenase)

PharmGKB "VIP" summary for NQO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NQO1 gene promoter:
AP-1 p53 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NQO1 promoter sequence

Search SABiosciences Chromatin IP Primers for NQO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NQO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q12-q22

NQO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NQO1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M069744: view genomic region (about GC identifiers)

Start:	69,740,899 bp from pter	End:	69,760,854 bp from pter
Size:	19,956 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559 (See protein sequence)

Recommended Name: NAD(P)H dehydrogenase [quinone] 1

Size: 274 amino acids; 30868 Da

Cofactor: FAD

Subunit: Homodimer

Subcellular location: Cytoplasm

Mass spectrometry: Mass=30864; Mass_error=6; Method=Electrospray; Range=1-274; Source=PubMed:11735396;

Miscellaneous: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency

6/10 PDB 3D structures from and Proteopedia for NQO1 (see all 10):

1D4A (3D)

1DXO (3D)

1GG5 (3D)

1H66 (3D)

1H69 (3D)

1KBO (3D)

Secondary accessions: B2R5Y9 B4DNM7 B7ZAD1 Q86UK1

Alternative splicing: 3 isoforms: P15559-1 P15559-2 P15559-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NQO1: NX_P15559

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15559

4 DME Specific Peptides for NQO1 (P15559)

GLSVGHHLGK

FCGFQVLEPQL

WFGVPAILKGWFERV

PLYFAPSSLFDLNFQAGFL

NQO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000894.1 NP_001020604.1 NP_001020605.1

ENSEMBL proteins:

ENSP00000456282 ENSP00000368335 ENSP00000319788 ENSP00000368334 ENSP00000398330

ENSP00000455020

Reactome Protein details: P15559
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for NQO1
	Uscn Proteins for NQO1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0043025	neuronal cell body	IEA	--

NQO1 for ontologies About GeneDecksing

NQO1 Antibody Products:

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	GenScript Superior Antibodies for NQO1
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	Abcam antibodies for NQO1
	Uscn Antibodies for NQO1
	ThermoFisher Antibody for NQO1

Assay Products for NQO1:

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	GenScript Custom Assay Services for NQO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NQO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NQO1 for domains About GeneDecksing

1 InterPro domain/family:

IPR003680 Flavodoxin_fold

Graphical View of Domain Structure for InterPro Entry P15559

ProtoNet protein and cluster: P15559

1 Blocks protein family: IPB003680 NAD(P)H dehydrogenase (quinone)

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons

involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent

gamma-carboxylation of glutamate residues in prothrombin synthesis

Catalytic activity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone

Enzyme regulation: Inhibited by dicoumarol

Induction: By dioxin

Enzyme Number (IUBMB): EC 1.6.5.2¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NQO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NQO1
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NQO1 (see all 14):
		hsa-miR-498 hsa-miR-623 hsa-miR-2114 hsa-miR-3938 hsa-miR-548am hsa-miR-1237 hsa-miR-211 hsa-miR-183*

		SwitchGear 3'UTR luciferase reporter plasmid: NQO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for NQO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NQO1
		Search LifeMap BioReagents cell lines for NQO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	IEA	--
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	TAS	9579781
GO:0004784	superoxide dismutase activity	IEA	--
GO:0005515	protein binding	IPI	--

NQO1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for NQO1: Nqo1^tm1Akj Nqo1^tm1Msho
     9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nqo1):

adipose tissue	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	tumorigenesis

NQO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway, Pharmacokinetics

1.00

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Acetaminophen Pathway, Pharmacokinetics

Acetaminophen metabolism

0.43

Acetaminophen metabolism

0.43

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NQO1

Acetaminophen metabolism

3 Cell Signaling Technology (CST) Pathways for NQO1

	Apoptosis and Autophagy
	Lymphocyte Signaling
	NF-kappaB Signaling

1 GeneGo (Thomson Reuters) Pathway for NQO1

Acetaminophen metabolism

3 BioSystems Pathways for NQO1

	Keap1-Nrf2 Pathway
	Estrogen metabolism
	Oxidative Stress

3 Reactome Pathways for NQO1

	Regulation of ornithine decarboxylase (ODC)
	Metabolism
	Metabolism of amino acids and derivatives

4 PharmGKB Pathways for NQO1

	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics
	Phenytoin Pathway, Pharmacokinetics
	Platinum Pathway, Pharmacokinetics/Pharmacodynamics

NQO1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NQO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/12 Interacting proteins for NQO1 (P15559^{1, 2, 3} ENSP00000319788⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ING1	Q9UK53²^,³, ENSP00000364929⁴	MINT-6616064 MINT-6616019 MINT-6616047 I2D: score=3 STRING: ENSP00000364929
HSPA1A	P08107³, ENSP00000364802⁴	I2D: score=2 STRING: ENSP00000364802
HSPA1B	P08107³	I2D: score=2
TP53	P04637³, ENSP00000269305⁴	I2D: score=2 STRING: ENSP00000269305
STUB1	Q9UNE7³, ENSP00000219548⁴	I2D: score=1 STRING: ENSP00000219548

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006521	regulation of cellular amino acid metabolic process	TAS	--
GO:0006801	superoxide metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	10393963
GO:0006809	nitric oxide biosynthetic process	TAS	9579781
GO:0006979	response to oxidative stress	IEA	--

NQO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NQO1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for NQO1

Browse Tocris compounds for NQO1

10 HMDB Compounds for NQO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Hydroquinone	1,4-Benzenediol (see all 35)	123-31-9	--
Menadione	Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)	58-27-5	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Quinone	1,4-Benzoquine (see all 25)	106-51-4	--
Reduced Vitamin K (phylloquinone)	vitamin K hydroquinone (phylloquinone)	81382-12-9	--
Vitamin K1	2',3'-trans-Vitamin K1 (see all 36)	12001-79-5	--

10/12 DrugBank Compounds for NQO1 (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dicumarol	Bis-Hydroxycoumarin (see all 4)	66-76-2	target	inhibitor	2113031 10755406 10949919 10419545 10874136 10683249
Menadione	2-Methyl-1,4-Naphthalenedione (see all 7)	58-27-5	target	--	10190578 12069105 10614691 10654840 10939639
5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione	--	--	target	--	17139284 17016423 10592235
5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione	--	--	target	--	17139284 17016423 10592235
Cibacron Blue	--	84166-13-2	target	--	17139284 17016423 10592235
Duroquinone	--	527-17-3	target	--	17139284 17016423 10592235
Flavin-Adenine Dinucleotide	--	146-14-5	target	--	17139284 17016423 10592235
2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione	--	--	target	--	17139284 17016423
3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol	--	--	target	--	17139284 17016423
3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE	--	--	target	--	10592235

10/130 Novoseek chemical compound relationships for NQO1 gene (see all 130) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dicoumarol	95.1	199	1718826 (7), 16700548 (4), 14634213 (4), 12171070 (3) (see all 95)
medzq	92.6	29	9865924 (4), 7565631 (3), 1406604 (2), 8137269 (2) (see all 12)
5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione	90.9	10	11735396 (1), 15102952 (1), 16891456 (1), 11377380 (1) (see all 8)
quinone	90.9	220	8657209 (4), 11862423 (4), 7780966 (3), 8653808 (3) (see all 99)
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	90.8	8	18794327 (1), 15940348 (1), 17015278 (1), 11377380 (1) (see all 7)
diaziquone	87.9	8	1301071 (1), 8375015 (1), 2113030 (1), 11999125 (1) (see all 6)
beta-lapachone	86.7	90	19738461 (6), 19657853 (5), 10681517 (4), 18283592 (4) (see all 23)
cb1954	85	9	8205540 (1), 10543876 (1), 8373433 (1), 1385952 (1) (see all 6)
menadione	82.3	76	9324955 (5), 10614691 (3), 18374191 (3), 16478651 (3) (see all 32)
streptonigrin	82.1	32	8615901 (3), 16003741 (3), 11377380 (2), 15655414 (2) (see all 14)

Search CenterWatch for drugs/clinical trials and news about NQO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NQO1 gene (3 alternative transcripts):

NM_000903.2 NM_001025433.1 NM_001025434.1

Unigene Cluster for NQO1:

NAD(P)H dehydrogenase, quinone 1

Hs.406515 [show with all ESTs]

Unigene Representative Sequence: NM_000903

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000561500 ENST00000379047(uc002exq.3 uc010vll.2) ENST00000320623(uc002exp.3 uc002exr.3)

ENST00000379046 ENST00000439109 ENST00000564043 ENST00000569118

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		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NQO1 (see all 14):
		hsa-miR-498 hsa-miR-623 hsa-miR-2114 hsa-miR-3938 hsa-miR-548am hsa-miR-1237 hsa-miR-211 hsa-miR-183*

		SwitchGear 3'UTR luciferase reporter plasmid: NQO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK223050.1 AK297125.1 AK297979.1 AK298896.1 AK307533.1 AK309513.1 AK312368.1 AK316246.1

BC000906.2 BC007659.2 BC107739.1 J03934.1

16 DOTS entries:

DT.100739730 DT.40222375 DT.95273877 DT.99982242 DT.120715278 DT.100031386 DT.91962533 DT.100853457

DT.100853467 DT.120715262 DT.92040555 DT.97855800 DT.120715271 DT.435292 DT.120715220 DT.120715052

24/672 AceView cDNA sequences (see all 672):

BM767057 BG032603 BM997193 CB129062 N47386 BM716149 BU175774 BM503845

BQ677502 BQ954230 CA312363 BU543786 AA306417 AA295488 D17043 BU727793

BM826228 CR623236 AI074406 CD609762 BM794520 BQ225286 CA310032 AI922277

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e	^	7
SP1:
SP2:																	-		-		-														-
SP3:															-		-
SP4:																	-		-		-
SP5:							-

ECgene alternative splicing isoforms for NQO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NQO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATCAAATC

About this image

NQO1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NQO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NQO1

SOURCE GeneReport for Unigene cluster: Hs.406515

SABiosciences Expression via Pathway-Focused PCR Arrays including NQO1 (see all 10):

Nephrotoxicity in human mouse rat

NFKB Signaling Targets in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Hepatotoxicity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NQO1 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NQO1¹	NAD(P)H dehydrogenase, quinone 1	61.8(n) 60.58(a)		769737 XM_003641950.1 XP_003641998.1
lizard (Anolis carolinensis)	Reptilia	NQO1⁶	--	64(a)	1 ↔ 1	GL343643.1(151524-154199)
zebrafish (Danio rerio)	Actinopterygii	nqo1¹	NAD(P)H dehydrogenase, quinone 1	58.27(n) 49.64(a)		322506 NM_205542.2 NP_991105.1
honey bee (Apis mellifera)	Insecta	--	--	21(a)	possible ortholog	GroupUn.6733(491-1051)
E. coli (Escherichia coli)	Gamma proteobacteria	kefF⁶ kefG⁶ (see all 3)	potassium-efflux system ancillary protein for KefC... potassium-efflux system ancillary protein for KefB... (see all 3)	28(a) 25(a) (see all 3)	possible ortholog possible ortholog (see all 3)	Chromosome(47246-47776) Chromosome(3478629-3479183)

ENSEMBL Gene Tree for NQO1 (if available)
TreeFam Gene Tree for NQO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NQO1 gene

NQO2²

1 SIMAP similar gene for NQO1 using alignment to 7 protein entries: NQO1_HUMAN (see all proteins):

NQO2

NQO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559

Polymorphism: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1800566^1,2	C,F,O,A,H,	pathogenic	55623238(-)	`TAGAAC/TCTCAA`	6	P S	mis¹ ese³		59		MN NA NS EA WA EU	13284
rs75026300^1,2	C,	--	55621180(+)	`TTGCAC/TGCAGC`	3	--	ds500¹		1		NA	120
rs79167227^1,2	C,F,	--	55621655(+)	`CATCAT/CTTCTC`	3	--	ut3¹		1		WA	118
rs34906225^1,2	C,F,	--	55621737(-)	`TCTCAT/ATCCAC`	3	--	ut3¹		8		MN CSA WA	529
rs8056468^1,2	H	--	55622196(+)	`tgatgG/Acaggc`	3	--	ut3¹		4		NS EA	418
rs34590494^1,2	F	--	55622335(-)	`AAAAWT/ATTTTT`	3	--	ut3¹		5		MN	408
rs35936271^1,2	C,F,	--	55622336(-)	`AAAAAA/TWTTTT`	3	--	ut3¹		5		MN	408
rs35105312^1,2	F	--	55622370(-)	`NTTTGC/TTGCAG`	3	--	ut3¹		5		MN	408
rs67058379^1,2	C	--	55622373(+)	`CAGCA-/AAGAAGAG`	6	--	ut3¹		0	--	--	--	--
rs34763938^1,2	F	--	55622377(-)	`ATCTCTTC/-TTTGY`	6	--	ut3¹		5		MN	408

HapMap Linkage Disequilibrium report for NQO1 (69740899 - 69760854 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NQO1
1 CNV: 49739
Human Gene Mutation Database (HGMD): NQO1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NQO1

DNA2.0 Custom Variant and Variant Library Synthesis for NQO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NQO1 for disorders           About GeneDecksing

OMIM gene information: 125860    OMIM disorders: --

20/116 diseases for NQO1 (see all 116):    About MalaCards

breast cancer, poor survival after chemotherapy for (3) 8 tardive dyskinesia leukemia, post-chemotherapy north american indian childhood cirrhosis

benzene toxicity alzheimer's disease nijmegen breakage syndrome diffuse large b-cell lymphoma

leber hereditary optic neuropathy anal canal carcinoma xeroderma pigmentosum patent ductus arteriosus

non-small cell lung carcinoma b-cell lymphomas pre-eclampsia balkan nephropathy

malignant pleural mesothelioma non-hodgkin lymphoma congestive heart failure colon cancer, advanced

2 diseases from the University of Copenhagen DISEASES database for NQO1:

Cancer Balkan nephropathy

10/71 Novoseek disease relationships for NQO1 gene (see all 71) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	61.9	34	8615901 (2), 9865924 (2), 1737339 (2), 8205521 (1) (see all 20)
cancer	54.3	92	16361576 (3), 18283592 (3), 15877230 (2), 11693537 (2) (see all 58)
nsclc	45.4	69	1324793 (6), 9748120 (5), 12370763 (3), 9865924 (3) (see all 20)
colon adenocarcinoma	44.8	9	8180125 (2), 8653808 (2), 15896333 (1), 11377380 (1) (see all 6)
lymphoblastic leukemia acute childhood	44.3	4	11774269 (1), 18945694 (1), 18024413 (1), 19593802 (1)
tumors	44.1	238	8375015 (6), 15877230 (5), 11350900 (5), 10845577 (4) (see all 99)
adult brain tumor	43.6	2	16598069 (1), 17372252 (1)
cancer lung	41.7	52	18798003 (6), 11319169 (5), 15781212 (5), 12711112 (3) (see all 26)
colon cancer	41.6	29	17164365 (5), 10391098 (2), 15877230 (1), 11894133 (1) (see all 11)
hepatoblastoma	40.2	8	1691923 (1), 1651729 (1), 1657151 (1), 1899380 (1) (see all 7)

Genetic Association Database (GAD): NQO1
Human Genome Epidemiology (HuGE) Navigator: NQO1 (282 documents)

Export disorders for NQO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NQO1 gene, integrated from 9 sources (see all 1019):
(articles sorted by number of sources associating them with NQO1)

Utopia: connect your pdf to the dynamic
world of online information

No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. (PubMed id 10447260)^{1, 2, 4} Kristiansen O.P.... Pociot F. (1999)
Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. (PubMed id 2843525)^{1, 2, 3} Jaiswal A.K.... Nebert D.W. (1988)
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT- diaphorase activity and mitomycin sensitivity. (PubMed id 1737339)^{1, 2, 9} Traver R.D.... Gibson N.W. (1992)
An association between a NQO1 genetic polymorphism and risk of lung cancer. (PubMed id 15781212)^{1, 4, 9} Saldivar S.J....Wu X. (2005)
An association between NQO1 genetic polymorphism and risk of bladder cancer. (PubMed id 12694753)^{1, 4, 9} Park S.J....Wu X. (2003)
[Genetic polymorphisms of NQO1, GSTT1, STM1 and susceptibility to chronic benzene poisoning.] (PubMed id 15748501)^{1, 4, 9} Chen Y....Wu C.L. (2005)
[Study on genetic polymorphism of NQO1 and susceptibility to benzene poisoning] (PubMed id 15727169)^{1, 4, 9} Chen Y....Li G. (2004)
Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations. (PubMed id 15138483)^{1, 4, 9} Menzel H.J....Kraft H.G. (2004)
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. (PubMed id 12460800)^{1, 4, 9} Wan J....Hu G. (2002)
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. (PubMed id 16079101)^{1, 4, 9} Dufour C.... . (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1728	HGNC: 2874	AceView: NQO1	Ensembl:ENSG00000181019	euGenes: HUgn1728
ECgene: NQO1	H-InvDB: NQO1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NQO1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NQO1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/nqo1/

Intellectual Property for NQO1 gene
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Patent Information for NQO1 gene:
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GeneCards and IP:
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NQO1 Gene

NAD(P)H dehydrogenase, quinone 1

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NQO1 (Gene Symbol)
NAD(P)H Dehydrogenase, Quinone 1
DIA4
NMOR1
DTD
QR1
DHQU
Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase)
Menadione Reductase
Phylloquinone Reductase
Quinone Reductase 1
DT-Diaphorase
NAD(P)H:Quinone Oxidoreductase 1
EC 1.6.5.2
NMORI
Azoreductase
Diaphorase-4
Dioxin-Inducible 1
NAD(P)H Dehydrogenase [Quinone] 1
NAD(P)H:Menadione Oxidoreductase 1
NAD(P)H:Quinone Acceptor Oxidoreductase Type 1
NAD(P)H:Quinone Oxireductase
Azoreductase

Lymphoblastic Leukemia Acute Childhood
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NQO1 Gene

NAD(P)H dehydrogenase, quinone 1

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