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NQO1 Gene

protein-coding   GIFtS: 71
GCID: GC16M069744

NAD(P)H Dehydrogenase, Quinone 1

(Previous name: diaphorase (NADH/NADPH) (cytochrome b-5 reductase))
(Previous symbols: NMOR1, DIA4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NAD(P)H Dehydrogenase, Quinone 11 2     EC 1.6.5.23 8
DIA41 2 3 5     DHQU2
NMOR11 2 3 5     NMORI2
Diaphorase (NADH/NADPH) (Cytochrome B-5 Reductase)1 2     azoreductase2
Menadione Reductase2 3     diaphorase-42
Phylloquinone Reductase2 3     Dioxin-Inducible 12
Quinone Reductase 12 3     NAD(P)H Dehydrogenase [Quinone] 12
DT-diaphorase2 3     NAD(P)H:Menadione Oxidoreductase 12
DTD2 3     NAD(P)H:Quinone Acceptor Oxidoreductase Type 12
QR12 3     NAD(P)H:Quinone Oxireductase2
NAD(P)H:Quinone Oxidoreductase 12 3     Azoreductase3

External Ids:    HGNC: 28741   Entrez Gene: 17282   Ensembl: ENSG000001810197   OMIM: 1258605   UniProtKB: P155593   

Export aliases for NQO1 gene to outside databases

Previous GC identifers: GC16M060424 GC16M070163 GC16M069478 GC16M069519 GC16M068300 GC16M055621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NQO1 Gene:
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron
reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's
enzymatic activity prevents the one electron reduction of quinones that results in the production of radical
species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of
hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of
this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul
2008)

GeneCards Summary for NQO1 Gene:
NQO1 (NAD(P)H dehydrogenase, quinone 1) is a protein-coding gene. Diseases associated with NQO1 include leukemia, post-chemotherapy, and breast cancer, poor survival after chemotherapy for. GO annotations related to this gene include NAD(P)H dehydrogenase (quinone) activity and cytochrome-b5 reductase activity, acting on NAD(P)H. An important paralog of this gene is NQO2.

UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559
Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of
hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin
K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis

Gene Wiki entry for NQO1 (NAD(P)H dehydrogenase) Gene

PharmGKB "VIP" summary for NQO1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NQO1 gene promoter:
         AP-1   p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNQO1 promoter sequence
   Search Chromatin IP Primers for NQO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NQO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q12-q22

NQO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NQO1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069744:  view genomic region     (about GC identifiers)

Start:
69,740,899 bp from pter      End:
69,760,854 bp from pter
Size:
19,956 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559 (See protein sequence)
Recommended Name: NAD(P)H dehydrogenase [quinone] 1  
Size: 274 amino acids; 30868 Da
Cofactor: FAD
Subunit: Homodimer
Mass spectrometry: Mass=30864; Mass_error=6; Method=Electrospray; Range=2-274; Source=PubMed:11735396;
Miscellaneous: Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency
Selected PDB 3D structures from and Proteopedia for NQO1 (see all 10):
1D4A (3D)        1DXO (3D)        1GG5 (3D)        1H66 (3D)        1H69 (3D)        1KBO (3D)    
Secondary accessions: B2R5Y9 B4DNM7 B7ZAD1 Q86UK1
Alternative splicing: 3 isoforms:  P15559-1   P15559-2   P15559-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NQO1: NX_P15559

Explore proteomics data for NQO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for NQO1 (P15559)
     GLSVGHHLGK  FCGFQVLEPQL  WFGVPAILKGWFERV  PLYFAPSSLFDLNFQAGFL 


    See NQO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000894.1  NP_001020604.1  NP_001020605.1  NP_001273066.1  

    ENSEMBL proteins: 
     ENSP00000456282   ENSP00000368335   ENSP00000319788   ENSP00000368334   ENSP00000398330  
     ENSP00000455020  
    Reactome Protein details: P15559

    NQO1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003680 Flavodoxin_fold

    Graphical View of Domain Structure for InterPro Entry P15559

    ProtoNet protein and cluster: P15559

    1 Blocks protein domain: IPB003680 NAD(P)H dehydrogenase (quinone)

    UniProtKB/Swiss-Prot: NQO1_HUMAN, P15559
    Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family


    NQO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NQO1_HUMAN, P15559
    Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of
    hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin
    K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis
    Catalytic activity: NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone
    Enzyme regulation: Inhibited by dicoumarol
    Induction: By dioxin

         Enzyme Number (IUBMB): EC 1.6.5.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003955NAD(P)H dehydrogenase (quinone) activity IEA--
    GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H TAS9579781
    GO:0004784superoxide dismutase activity IEA--
    GO:0005515protein binding IPI18388957
    GO:0016491oxidoreductase activity ----
         
    NQO1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nqo1):
     adipose tissue  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  tumorigenesis 

    NQO1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NQO1: Nqo1tm1Akj Nqo1tm1Msho

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NQO1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NQO1 (see all 14):
    hsa-miR-498 hsa-miR-623 hsa-miR-2114 hsa-miR-3938 hsa-miR-548am hsa-miR-1237 hsa-miR-211 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidNQO1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NQO1

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    GenScript: all cDNA clones in your preferred vector (see all 3): NQO1 (NM_000903)
    Sino Biological Human cDNA Clone for NQO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NQO1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NQO1_HUMAN, P15559: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0043025neuronal cell body IEA--

    NQO1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NQO1 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Acetaminophen metabolism0.00
    Phenytoin Pathway, Pharmacokinetics0.00
    2Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43
    3CDK-mediated phosphorylation and removal of Cdc6
    Regulation of ornithine decarboxylase (ODC)0.80
    4Estrogen metabolism
    Estrogen metabolism0.43
    5Ubiquinol biosynthesis
    Ubiquinone and other terpenoid-quinone biosynthesis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NQO1
        Apoptosis and Autophagy
    Lymphocyte Signaling
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for NQO1
        Acetaminophen metabolism

    5 BioSystems Pathways for NQO1
        Keap1-Nrf2 Pathway
    Oxidative Stress
    Estrogen metabolism
    AhR pathway
    Dopamine metabolism


    1 Reactome Pathway for NQO1
        Regulation of ornithine decarboxylase (ODC)

    4 PharmGKB Pathways for NQO1
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Phenytoin Pathway, Pharmacokinetics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NQO1):
        Ubiquinone and other terpenoid-quinone biosynthesis


    NQO1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NQO1 (see all 10): 
              Nephrotoxicity in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NQO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for NQO1 (P155591, 2, 3 ENSP000003197884) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006801superoxide metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS10393963
    GO:0006809nitric oxide biosynthetic process TAS9579781
    GO:0006979response to oxidative stress IEA--

    NQO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NQO1
      Browse compounds at ApexBio 

    Browse Tocris compounds for NQO1

    10 HMDB Compounds for NQO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydroquinone1,4-Benzenediol (see all 35)123-31-9--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Quinone1,4-Benzoquine (see all 25)106-51-4--
    Reduced Vitamin K (phylloquinone)vitamin K hydroquinone (phylloquinone) 81382-12-9--
    Vitamin K12',3'-trans-Vitamin K1 (see all 36)12001-79-5--

    Selected DrugBank Compounds for NQO1 (see all 16)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DicumarolBis-Hydroxycoumarin (see all 4)66-76-2targetinhibitor2113031 10755406 10949919 10419545 10874136 10683249
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5target--10190578 12069105 10614691 10654840 10939639
    5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione-- --target--17139284 17016423 10592235
    5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione-- --target--17139284 17016423 10592235
    Cibacron Blue-- 84166-13-2target--17139284 17016423 10592235
    Duroquinone-- 527-17-3target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    2,5-Diaziridin-1-Yl-3-(Hydroxymethyl)-6-Methylcyclohexa-2,5-Diene-1,4-Dione-- --target--17139284 17016423
    3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol-- --target--17139284 17016423
    DoxorubicinAdria (see all 4)23214-92-8enzymesubstrate10860924 12688675

    Selected Novoseek inferred chemical compound relationships for NQO1 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dicoumarol 95.1 199 1718826 (7), 16700548 (4), 14634213 (4), 12171070 (3) (see all 95)
    medzq 92.6 29 9865924 (4), 7565631 (3), 1406604 (2), 8137269 (2) (see all 12)
    5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione 90.9 10 11735396 (1), 15102952 (1), 16891456 (1), 11377380 (1) (see all 8)
    quinone 90.9 220 8657209 (4), 11862423 (4), 7780966 (3), 8653808 (3) (see all 99)
    2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone 90.8 8 18794327 (1), 15940348 (1), 17015278 (1), 11377380 (1) (see all 7)
    diaziquone 87.9 8 1301071 (1), 8375015 (1), 2113030 (1), 11999125 (1) (see all 6)
    beta-lapachone 86.7 90 19738461 (6), 19657853 (5), 10681517 (4), 18283592 (4) (see all 23)
    cb1954 85 9 8205540 (1), 10543876 (1), 8373433 (1), 1385952 (1) (see all 6)
    menadione 82.3 76 9324955 (5), 10614691 (3), 18374191 (3), 16478651 (3) (see all 32)
    streptonigrin 82.1 32 8615901 (3), 16003741 (3), 11377380 (2), 15655414 (2) (see all 14)



    NQO1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NQO1 gene (4 alternative transcripts): 
    NM_000903.2  NM_001025433.1  NM_001025434.1  NM_001286137.1  

    Unigene Cluster for NQO1:

    NAD(P)H dehydrogenase, quinone 1
    Hs.406515  [show with all ESTs]
    Unigene Representative Sequence: NM_000903
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561500 ENST00000379047(uc002exq.3 uc010vll.2) ENST00000320623(uc002exp.3 uc002exr.3)
    ENST00000379046 ENST00000439109 ENST00000564043 ENST00000569118
    miRNA
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    hsa-miR-498 hsa-miR-623 hsa-miR-2114 hsa-miR-3938 hsa-miR-548am hsa-miR-1237 hsa-miR-211 hsa-miR-183*
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    Additional mRNA sequence: 

    AK223050.1 AK297125.1 AK297979.1 AK298896.1 AK307533.1 AK309513.1 AK312368.1 AK316246.1 
    BC000906.2 BC007659.2 BC107739.1 J03934.1 

    16 DOTS entries:

    DT.100739730  DT.40222375  DT.95273877  DT.99982242  DT.120715278  DT.100031386  DT.91962533  DT.100853457 
    DT.100853467  DT.120715262  DT.92040555  DT.97855800  DT.120715271  DT.435292  DT.120715220  DT.120715052 

    Selected AceView cDNA sequences (see all 672):

    BG576196 BM782665 CN482595 CB107108 AW084444 BU175774 AI074406 BM789940 
    BM794520 BM850789 BQ958874 AW073823 BM503845 BQ954230 CB118323 CA430543 
    BM781786 BM767057 AA037142 BM990575 BU727793 CD014005 AI922277 BQ924647 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NQO1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
    SP1:                                                                                                                  
    SP2:                                                  -     -     -                                         -         
    SP3:                                            -     -                                                               
    SP4:                                                  -     -     -                                                   
    SP5:                    -                                                                                             


    ECgene alternative splicing isoforms for NQO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NQO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATCAAATC
    NQO1 Expression
    About this image


    NQO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental pulp stem cells
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
    NQO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NQO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406515
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NQO1 (see all 10): 
              Nephrotoxicity in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NQO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for NQO1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nqo11 , 5 NAD(P)H dehydrogenase, quinone 11, 5 85.89(n)1
    86.5(a)1
      8 (54.08 cM)5
    181041  NM_008706.51  NP_032732.31 
     1073882255 
    chicken
    (Gallus gallus)
    Aves NQO11 NAD(P)H dehydrogenase, quinone 1 61.68(n)
    60.58(a)
      769737  NM_001277619.1  NP_001264548.1 
    lizard
    (Anolis carolinensis)
    Reptilia NQO16
    NAD(P)H dehydrogenase, quinone 1
    65(a)
    1 ↔ 1
    GL343643.1(151524-157155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nqo11 NAD(P)H dehydrogenase, quinone 1 66.79(n)
    63.24(a)
      549222  NM_001016468.2  NP_001016468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nqo11 NAD(P)H dehydrogenase, quinone 1 58.27(n)
    49.64(a)
      322506  NM_001204272.1  NP_001191201.1 


    ENSEMBL Gene Tree for NQO1 (if available)
    TreeFam Gene Tree for NQO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NQO1 gene
    NQO22  
    1 SIMAP similar gene for NQO1 using alignment to 7 protein entries:     NQO1_HUMAN (see all proteins):
    NQO2

    NQO1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NQO1_HUMAN, P15559: The Ser-187 polymorphism may be linked to susceptibility to forms of cancers


    Selected SNPs for NQO1 (see all 445)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18005661,2,,4
    C,F,O,A,Hpathogenic170751791(-) TAGAAC/TCTCAA 6 P S mis1 ese359Minor allele frequency- T:0.24MN NA NS EA WA EU 13284
    rs768417251,2
    --69751403(+) AACTGC/AAGGAA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs114239971,2
    C--69752937(+) AAAAA-/A/AA  
            
    GATGC
    3 -- int1 trp31NA 2
    rs105956841,2
    C--69759782(+) aaaac-/AAAA  
      CAAAAC
    CTGTG
    3 -- int10--------
    rs579423481,2
    C--69759782(+) AAAAC-/AAAAC 
            
    CTGTG
    3 -- int11Minor allele frequency- AAAAC:0.00NA 2
    rs1819743281,2
    --70749476(+) TTATTG/TTTTTG 3 -- ds50010--------
    rs1466592101,2
    --70749550(+) ACCTCC/TGCCTC 3 -- ds50010--------
    rs1858286791,2
    --70749558(+) CTCCCA/GGGTTC 3 -- ds50010--------
    rs1492282041,2
    --70749612(+) GGCCCA/GCACCA 3 -- ds50010--------
    rs750263001,2
    C,F--70749733(+) TTGCAC/TGCAGC 3 -- ds50011Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for NQO1 (69740899 - 69760854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NQO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524364CNV Loss19592680
    nsv517207CNV Loss19592680
    nsv906823CNV Gain21882294
    nsv906822CNV Gain21882294

    Human Gene Mutation Database (HGMD): NQO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NQO1
    DNA2.0 Custom Variant and Variant Library Synthesis for NQO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 125860    OMIM disorders: --

    Selected diseases for NQO1 (see all 107):    
    About MalaCards
    leukemia, post-chemotherapy    breast cancer, poor survival after chemotherapy for    benzene toxicity    balkan nephropathy
    tardive dyskinesia    colon cancer, advanced    atrophy of testis    anal canal carcinoma
    hepatocellular adenoma    alcoholic pancreatitis    nijmegen breakage syndrome    colon adenocarcinoma
    north american indian childhood cirrhosis    childhood leukemia    breast adenocarcinoma    barrett esophagus/esophageal adenocarcinoma
    polyploidy    lymphoblastic leukemia    leber hereditary optic neuropathy    hepatoblastoma

    2 diseases from the University of Copenhagen DISEASES database for NQO1:
    Cancer     Atrophy of testis

    NQO1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NQO1 gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 61.9 34 8615901 (2), 9865924 (2), 1737339 (2), 8205521 (1) (see all 20)
    cancer 54.3 92 16361576 (3), 18283592 (3), 15877230 (2), 11693537 (2) (see all 58)
    nsclc 45.4 69 1324793 (6), 9748120 (5), 12370763 (3), 9865924 (3) (see all 20)
    colon adenocarcinoma 44.8 9 8180125 (2), 8653808 (2), 15896333 (1), 11377380 (1) (see all 6)
    lymphoblastic leukemia acute childhood 44.3 4 11774269 (1), 18945694 (1), 18024413 (1), 19593802 (1)
    tumors 44.1 238 8375015 (6), 15877230 (5), 11350900 (5), 10845577 (4) (see all 99)
    adult brain tumor 43.6 2 16598069 (1), 17372252 (1)
    cancer lung 41.7 52 18798003 (6), 11319169 (5), 15781212 (5), 12711112 (3) (see all 26)
    colon cancer 41.6 29 17164365 (5), 10391098 (2), 15877230 (1), 11894133 (1) (see all 11)
    hepatoblastoma 40.2 8 1691923 (1), 1651729 (1), 1657151 (1), 1899380 (1) (see all 7)

    Genetic Association Database (GAD): NQO1
    Human Genome Epidemiology (HuGE) Navigator: NQO1 (282 documents)

    Export disorders for NQO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NQO1 gene, integrated from 10 sources (see all 1063):
    (articles sorted by number of sources associating them with NQO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. (PubMed id 10447260)1, 2, 4 Kristiansen O.P.... Pociot F. (Hum. Mutat. 1999)
    2. Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. (PubMed id 2843525)1, 2, 3 Jaiswal A.K.... Nebert D.W. (J. Biol. Chem. 1988)
    3. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT- diaphorase activity and mitomycin sensitivity. (PubMed id 1737339)1, 2, 9 Traver R.D.... Gibson N.W. (Cancer Res. 1992)
    4. Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma. (PubMed id 19688691)1, 4, 9 Chiu M.M....Chau Y.P. (Histol. Histopathol. 2009)
    5. An association between a NQO1 genetic polymorphism and risk of lung cancer. (PubMed id 15781212)1, 4, 9 Saldivar S.J....Wu X. (Mutat. Res. 2005)
    6. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (PubMed id 18798003)1, 4, 9 Eom S.Y....Kim H. (amp 2009)
    7. An association between NQO1 genetic polymorphism and risk of bladder cancer. (PubMed id 12694753)1, 4, 9 Park S.J....Wu X. (Mutat. Res. 2003)
    8. The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior. (PubMed id 11319169)1, 4, 9 Xu L.L....Christiani D.C. (amp 2001)
    9. Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran. (PubMed id 20198579)1, 4, 9 Marjani H.A....Malekzadeh R. (Genet. Mol. Res. 2010)
    10. Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia. (PubMed id 18676018)1, 4, 9 Begleiter A....Johnston J.B. (Leuk. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1728 HGNC: 2874 AceView: NQO1 Ensembl:ENSG00000181019 euGenes: HUgn1728
    ECgene: NQO1 Kegg: 1728 H-InvDB: NQO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NQO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NQO1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nqo1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NQO1 gene:
    Search GeneIP for patents involving NQO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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