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Aliases for NPY6R Gene

Aliases for NPY6R Gene

  • Neuropeptide Y Receptor Y6 (Pseudogene) 2 3 5
  • NPY1RL 3 4
  • PP2 3 4
  • Y2B 3 4
  • Putative Pancreatic Polypeptide Receptor 2 4
  • NPY Y1-Like Receptor 4
  • NPY6RP 3
  • NPY6-R 4

External Ids for NPY6R Gene

Previous GeneCards Identifiers for NPY6R Gene

  • GC05P137018
  • GC05P137174
  • GC05P137213
  • GC05P137220
  • GC05P137171
  • GC05P132328

Summaries for NPY6R Gene

GeneCards Summary for NPY6R Gene

NPY6R (Neuropeptide Y Receptor Y6 (Pseudogene)) is a Pseudogene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include neuropeptide Y receptor activity.

UniProtKB/Swiss-Prot for NPY6R Gene

  • When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.

Gene Wiki entry for NPY6R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY6R Gene

Genomics for NPY6R Gene

Regulatory Elements for NPY6R Gene

Enhancers for NPY6R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F137953 0.8 Ensembl ENCODE 4.4 +153.2 153184 1.6 JUND PBX2 JUN SIN3A FOS RAD21 RNU6-1148P NPY6R GC05P137937 GC05M137959
GH05F137833 1.5 FANTOM5 Ensembl ENCODE 0.3 +35.0 35023 5.9 PKNOX1 SIN3A FEZF1 GATA2 FOS SP3 YY2 TSHZ1 ZNF264 MAFF MYOT HNRNPA0 CDC23 KDM3B RNU6-1148P KLHL3 PKD2L2 GC05M137818 NPY6R
GH05F137855 1 Ensembl ENCODE 0.2 +56.4 56415 3.6 RING1 PKNOX1 MTA2 RNF2 JUNB DPF2 TBX21 NR2F2 JUND CTBP1 PKD2L2 NME5 CDC23 RNU6-1148P GC05M137818 NPY6R
GH05F137827 0.4 ENCODE 0.3 +27.6 27557 2.1 PRDM1 MYOT RNU6-888P NME5 RNU6-1148P PKD2L2 NPY6R GC05M137818
GH05F137829 0.4 ENCODE 0.3 +29.0 29048 0.8 ZNF600 MYOT RNU6-1148P NPY6R GC05M137818
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPY6R on UCSC Golden Path with GeneCards custom track

Genomic Location for NPY6R Gene

Chromosome:
5
Start:
137,801,193 bp from pter
End:
137,810,751 bp from pter
Size:
9,559 bases
Orientation:
Plus strand

Genomic View for NPY6R Gene

Genes around NPY6R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY6R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY6R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY6R Gene

Proteins for NPY6R Gene

  • Protein details for NPY6R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99463-NPY6R_HUMAN
    Recommended name:
    Putative neuropeptide Y receptor type 6
    Protein Accession:
    Q99463
    Secondary Accessions:
    • D3DQB4

    Protein attributes for NPY6R Gene

    Size:
    290 amino acids
    Molecular mass:
    33180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPY6R Gene

Post-translational modifications for NPY6R Gene

  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPY6R Gene

Domains & Families for NPY6R Gene

Gene Families for NPY6R Gene

Protein Domains for NPY6R Gene

Suggested Antigen Peptide Sequences for NPY6R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99463

UniProtKB/Swiss-Prot:

NPY6R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY6R: view

Function for NPY6R Gene

Molecular function for NPY6R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y6,expressed in pancreas,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.

Gene Ontology (GO) - Molecular Function for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IBA --
GO:0004983 NOT neuropeptide Y receptor activity IKR 8910290
genes like me logo Genes that share ontologies with NPY6R: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY6R

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPY6R Gene

Localization for NPY6R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY6R Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with NPY6R: view

No data available for Subcellular locations from COMPARTMENTS for NPY6R Gene

Pathways & Interactions for NPY6R Gene

genes like me logo Genes that share pathways with NPY6R: view

Pathways by source for NPY6R Gene

2 BioSystems pathways for NPY6R Gene

Interacting Proteins for NPY6R Gene

Gene Ontology (GO) - Biological Process for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 NOT G-protein coupled receptor signaling pathway IKR 8910290
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007631 feeding behavior IBA --
GO:0008015 blood circulation IBA --
genes like me logo Genes that share ontologies with NPY6R: view

No data available for SIGNOR curated interactions for NPY6R Gene

Transcripts for NPY6R Gene

mRNA/cDNA for NPY6R Gene

(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY6R Gene

Neuropeptide Y receptor Y6 (pseudogene):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY6R Gene

No ASD Table

Relevant External Links for NPY6R Gene

GeneLoc Exon Structure for
NPY6R
ECgene alternative splicing isoforms for
NPY6R

Expression for NPY6R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY6R Gene

mRNA differential expression in normal tissues according to GTEx for NPY6R Gene

This gene is overexpressed in Heart - Left Ventricle (x29.4) and Heart - Atrial Appendage (x13.6).

NURSA nuclear receptor signaling pathways regulating expression of NPY6R Gene:

NPY6R

SOURCE GeneReport for Unigene cluster for NPY6R Gene:

Hs.643466

mRNA Expression by UniProt/SwissProt for NPY6R Gene:

Q99463-NPY6R_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain and adrenal glands.
genes like me logo Genes that share expression patterns with NPY6R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY6R Gene

Orthologs for NPY6R Gene

Evolution for NPY6R Gene

ENSEMBL:
Gene Tree for NPY6R (if available)
TreeFam:
Gene Tree for NPY6R (if available)

No data available for Orthologs for NPY6R Gene

Paralogs for NPY6R Gene

(11) SIMAP similar genes for NPY6R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY6R: view

No data available for Paralogs for NPY6R Gene

Variants for NPY6R Gene

Sequence variations from dbSNP and Humsavar for NPY6R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1048959 -- 137,808,300(+) CAACC(C/T)CCTTC nc-transcript-variant
rs111554691 -- 137,810,900(+) TATCA(C/T)TTTGG downstream-variant-500B
rs111744595 -- 137,801,036(+) ATATA(C/T)ATATA upstream-variant-2KB
rs112249067 -- 137,805,103(+) GTGCC(-/TT)GCCCC intron-variant
rs113474186 -- 137,810,091(+) TCTTT(A/G)TGTAT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY6R Gene

Variant ID Type Subtype PubMed ID
nsv830501 CNV gain 17160897
nsv830500 CNV loss 17160897
esv3606910 CNV loss 21293372
esv3570428 CNV loss 25503493
esv2671421 CNV deletion 23128226

Relevant External Links for NPY6R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY6R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPY6R Gene

Disorders for NPY6R Gene

Relevant External Links for NPY6R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY6R

No disorders were found for NPY6R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY6R Gene

Publications for NPY6R Gene

  1. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. (PMID: 8910290) Matsumoto M. … Yamaguchi T. (J. Biol. Chem. 1996) 2 3 4 64
  2. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. (PMID: 8910373) Gregor P. … McCaleb M.L. (J. Biol. Chem. 1996) 2 3 4 64
  3. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? (PMID: 11027673) StarbAock P. … Larhammar D. (Biochem. Biophys. Res. Commun. 2000) 3 22 64
  4. Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine 'Y5' receptor may be a pseudogene. (PMID: 9013614) Rose P.M. … Fernandes P. (J. Biol. Chem. 1997) 3 4 64
  5. Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region. (PMID: 16640567) BromAce T. … Larhammar D. (FEBS J. 2006) 22 64

Products for NPY6R Gene

Sources for NPY6R Gene

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