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Aliases for NPY6R Gene

Aliases for NPY6R Gene

  • Neuropeptide Y Receptor Y6 (Pseudogene) 2 3
  • PP2 3 4 6
  • NPY1RL 3 4
  • Y2B 3 4
  • Putative Pancreatic Polypeptide Receptor 2 4
  • NPY Y1-Like Receptor 4
  • NPY6RP 3
  • NPY6-R 4

External Ids for NPY6R Gene

Previous GeneCards Identifiers for NPY6R Gene

  • GC05P137018
  • GC05P137174
  • GC05P137213
  • GC05P137220
  • GC05P137171
  • GC05P132328

Summaries for NPY6R Gene

GeneCards Summary for NPY6R Gene

NPY6R (Neuropeptide Y Receptor Y6 (Pseudogene)) is a Pseudogene. Among its related pathways are Peptide ligand-binding receptors and Peptide ligand-binding receptors.

UniProtKB/Swiss-Prot for NPY6R Gene

  • When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.

Gene Wiki entry for NPY6R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY6R Gene

Genomics for NPY6R Gene

Regulatory Elements for NPY6R Gene

Genomic Location for NPY6R Gene

Start:
137,801,193 bp from pter
End:
137,810,751 bp from pter
Size:
9,559 bases
Orientation:
Plus strand

Genomic View for NPY6R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY6R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY6R Gene

Proteins for NPY6R Gene

  • Protein details for NPY6R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99463-NPY6R_HUMAN
    Recommended name:
    Putative neuropeptide Y receptor type 6
    Protein Accession:
    Q99463
    Secondary Accessions:
    • D3DQB4

    Protein attributes for NPY6R Gene

    Size:
    290 amino acids
    Molecular mass:
    33180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPY6R Gene

Proteomics data for NPY6R Gene at MOPED

Post-translational modifications for NPY6R Gene

  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPY6R Gene

Domains for NPY6R Gene

Gene Families for NPY6R Gene

HGNC:
  • NPYR :GPCR / Class A : Neuropeptide receptors : Y
IUPHAR :

Protein Domains for NPY6R Gene

Suggested Antigen Peptide Sequences for NPY6R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99463

UniProtKB/Swiss-Prot:

NPY6R_HUMAN :
  • Q99463
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY6R: view

Function for NPY6R Gene

Molecular function for NPY6R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y6,expressed in pancreas,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.

Gene Ontology (GO) - Molecular Function for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004983 NOT neuropeptide Y receptor activity IKR 8910290
genes like me logo Genes that share ontologies with NPY6R: view

Phenotypes for NPY6R Gene

MGI mutant phenotypes for NPY6R:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPY6R: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPY6R Gene

Localization for NPY6R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY6R Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY6R: view

No data available for Subcellular locations from COMPARTMENTS for NPY6R Gene

Pathways for NPY6R Gene

genes like me logo Genes that share pathways with NPY6R: view

Pathways by source for NPY6R Gene

2 BioSystems pathways for NPY6R Gene

Interacting Proteins for NPY6R Gene

Gene Ontology (GO) - Biological Process for NPY6R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 NOT G-protein coupled receptor signaling pathway IKR 8910290
genes like me logo Genes that share ontologies with NPY6R: view

Transcripts for NPY6R Gene

mRNA/cDNA for NPY6R Gene

(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY6R Gene

Neuropeptide Y receptor Y6 (pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY6R

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY6R Gene

No ASD Table

Relevant External Links for NPY6R Gene

GeneLoc Exon Structure for
NPY6R
ECgene alternative splicing isoforms for
NPY6R

Expression for NPY6R Gene

mRNA expression in normal human tissues for NPY6R Gene

mRNA differential expression in normal tissues according to GTEx for NPY6R Gene

This gene is overexpressed in Heart - Left Ventricle (29.4) and Heart - Atrial Appendage (13.6).

SOURCE GeneReport for Unigene cluster for NPY6R Gene Hs.643466

mRNA Expression by UniProt/SwissProt for NPY6R Gene

Q99463-NPY6R_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain and adrenal glands.
genes like me logo Genes that share expressions with NPY6R: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for NPY6R Gene

Orthologs for NPY6R Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for NPY6R Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Npy6r 16
Species with no ortholog for NPY6R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPY6R Gene

ENSEMBL:
Gene Tree for NPY6R (if available)
TreeFam:
Gene Tree for NPY6R (if available)

Paralogs for NPY6R Gene

Selected SIMAP similar genes for NPY6R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY6R: view

No data available for Paralogs for NPY6R Gene

Variants for NPY6R Gene

Sequence variations from dbSNP and Humsavar for NPY6R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1048959 -- 137,808,300(+) CAACC(C/T)CCTTC nc-transcript-variant
rs2228647 -- 137,808,752(+) CTTCC(A/G)CAACC nc-transcript-variant
rs4835734 -- 137,804,608(+) GGCAC(A/G)GTGGC intron-variant
rs7708968 -- 137,803,328(+) GACAG(A/G)AGAAA intron-variant
rs9327801 -- 137,810,168(+) TTAGC(A/G)CCAGA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY6R Gene

Variant ID Type Subtype PubMed ID
nsv830500 CNV Loss 17160897
nsv830501 CNV Gain 17160897
esv2671421 CNV Deletion 23128226

Relevant External Links for NPY6R Gene

HapMap Linkage Disequilibrium report
NPY6R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY6R Gene

Disorders for NPY6R Gene

No disorders were found for NPY6R Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NPY6R Gene

Publications for NPY6R Gene

  1. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. (PMID: 8910290) Matsumoto M. … Yamaguchi T. (J. Biol. Chem. 1996) 2 3 4
  2. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. (PMID: 8910373) Gregor P. … McCaleb M.L. (J. Biol. Chem. 1996) 2 3 4
  3. Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine 'Y5' receptor may be a pseudogene. (PMID: 9013614) Rose P.M. … Fernandes P. (J. Biol. Chem. 1997) 3 4
  4. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? (PMID: 11027673) StarbAock P. … Larhammar D. (Biochem. Biophys. Res. Commun. 2000) 3 23
  5. Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region. (PMID: 16640567) BromAce T. … Larhammar D. (FEBS J. 2006) 23

Products for NPY6R Gene

Sources for NPY6R Gene

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