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NPY5R Gene

protein-coding   GIFtS: 62
GCID: GC04P164265

Neuropeptide Y Receptor Y5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide Y Receptor Y51 2     NPY-Y5 Receptor2 3
NPY5-R2 3     Y5 Receptor2 3
NPYR52 3     Neuropeptide Y Receptor Type 52
NPYY5-R2 3     

External Ids:    HGNC: 79581   Entrez Gene: 48892   Ensembl: ENSG000001641297   OMIM: 6020015   UniProtKB: Q157613   

Export aliases for NPY5R gene to outside databases

Previous GC identifers: GC04P165118 GC04P164696 GC04P164842 GC04P164622 GC04P164484 GC04P160019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPY5R Gene:
NPY5R (neuropeptide Y receptor Y5) is a protein-coding gene. Diseases associated with NPY5R include papillon-lefevre disease, and cocaine dependence. GO annotations related to this gene include neuropeptide Y receptor activity and pancreatic polypeptide receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that
inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding
disorders

summary for NPY5R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY5R (Neuropeptide Y receptor Y5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPY5R gene promoter:
         GR   ISGF-3   SREBP-1c   XBP-1   HNF-1A   SREBP-1b   Evi-1   SREBP-1a   HNF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY5R promoter sequence
   Search Chromatin IP Primers for NPY5R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY5R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31-q32   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q31-q32

NPY5R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY5R gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P164265:  view genomic region     (about GC identifiers)

Start:
164,265,091 bp from pter      End:
164,273,086 bp from pter
Size:
7,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 5  
Size: 445 amino acids; 50727 Da
Sequence caution: Sequence=AAC50623.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for NPY5R:
2HE6 (3D)    
Secondary accessions: Q6GTR7 Q92916

Explore the universe of human proteins at neXtProt for NPY5R: NX_Q15761

Explore proteomics data for NPY5R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn17

  • See NPY5R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006165.1  
    ENSEMBL proteins: 
     ENSP00000339377   ENSP00000423917   ENSP00000423474  
    Reactome Protein details: Q15761

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: Y5 receptor
    Neuropeptide Y receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000393 NPY5_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q15761

    ProtoNet protein and cluster: Q15761

    2 Blocks protein domains:
    IPB000393 Neuropeptide Y5 receptor signature
    IPB000611 Neuropeptide Y receptor signature


    UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NPY5R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY5R_HUMAN, Q15761
    Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that
    inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding
    disorders

         Genatlas biochemistry entry for NPY5R:
    neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0001602pancreatic polypeptide receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity TAS8824284
         
    NPY5R for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPY5R:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Npy5r):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 

    NPY5R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Npy5rtm1Aka for NPY5R

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY5R
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPY5R_HUMAN, Q15761: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8824284
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    NPY5R for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPY5R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NPY5R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NPY5R
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for NPY5R):
        Neuroactive ligand-receptor interaction


    NPY5R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY5R: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPY5R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY5R (Q157613 ENSP000003393774) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IEA--
    GO:0003151outflow tract morphogenesis IMP19593212
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0007186G-protein coupled receptor signaling pathway TAS8824284
    GO:0007218neuropeptide signaling pathway TAS8824284

    NPY5R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPY5R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    Selected IUPHAR Ligands for NPY5R (Y5 receptor) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    [Leu31,Pro34]NPY (pig)
    AgonistFull agonist9.18824284
    neuropeptide Y
    AgonistFull agonist9.18824284
    NPY-(2-36)
    AgonistFull agonist8.98824284
    peptide YY
    AgonistFull agonist8.98824284
    [Leu31,Pro34]PYY (human)
    AgonistFull agonist8.88824284
    [PP1-17,Ala31,Aib32]NPY (human)
    AgonistFull agonist8.812890716
    FMS586
    AntagonistAntagonist8.416436501
    [Ala31,Aib32]NPY (pig)
    AgonistFull agonist8.212069595
    [D-Trp32]NPY
    AgonistFull agonist8.18824284
    NPY-(3-36) (pig)
    AgonistFull agonist88824284

    Selected Novoseek inferred chemical compound relationships for NPY5R gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibp3226 75.2 4 10422644 (1), 9462897 (1), 10465275 (1)
    biie0246 68.3 1 17265460 (1)
    benzimidazole 31.6 2 18723347 (1), 18752943 (1)
    cyclic amp 24.1 2 20332211 (1), 15771450 (1)
    lead 24 2 11858996 (1), 18752943 (1)
    isoniazid 9.42 2 15358298 (2)
    calcium 2.9 5 14599717 (2), 10872822 (1), 9854049 (1)
    ethanol 0 4 16377459 (2), 12626767 (1)
    sodium 0 1 11390018 (1)
    forskolin 0 1 10737676 (1)



    NPY5R for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPY5R gene: 
    NM_006174.2  

    Unigene Clusters for NPY5R:

    Neuropeptide Y receptor Y5
    Hs.519058  [show with all ESTs], Hs.598503
    Unigene Representative Sequences: BC034224, U56079
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338566(uc003iqn.3) ENST00000515560 ENST00000506953(uc021xtw.1)

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    Additional mRNA sequence: U56079.1 

    5 DOTS entries:

    DT.92416492  DT.106215  DT.99995306  DT.121236625  DT.92416494 

    11 AceView cDNA sequences:

    U56079 BI488524 U94320 BC042416 NM_006174 U66275 BC034224 BX461151 
    BE972691 BG191732 BG773165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPY5R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTCCTGTT
    NPY5R Expression
    About this image


    NPY5R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Substantia Nigra   
    NPY5R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY5R Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.519058 Hs.598503

    UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
    Tissue specificity: Brain; hypothalamus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY5R: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY5R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPY5R gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npy5r1 , 5 neuropeptide Y receptor Y51, 5 84.98(n)1
    89.41(a)1
      8 (33.15 cM)5
    181681  NM_016708.31  NP_057917.21 
     666799655 
    chicken
    (Gallus gallus)
    Aves NPY5R1 neuropeptide Y receptor Y5 71.5(n)
    70.29(a)
      422419  NM_001031130.1  NP_001026301.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY5R6
    neuropeptide Y receptor Y5
    73(a)
    1 ↔ 1
    5(126086699-126087931)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npy5r1 neuropeptide Y receptor Y5 69.21(n)
    70.79(a)
      779693  NM_001078776.1  NP_001072244.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npy8br6
    neuropeptide Y receptor Y8b
    27(a)
    many ↔ many
    8(53912915-53914042) ENSDARG00000005780
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR11 neuropeptide F receptor 43.25(n)
    33.99(a)
      40754  NM_079521.4  NP_524245.3 
    worm
    (Caenorhabditis elegans)
    Secernentea npr-126
    npr-116
    Protein NPR-11 (npr-11) mRNA, complete cds
    23(a)
    22(a)
    many ↔ many
    many ↔ many
    IV(6929088-6931118) WBGene00020689
    X(1251998-1255629) WBGene00016110


    ENSEMBL Gene Tree for NPY5R (if available)
    TreeFam Gene Tree for NPY5R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPY5R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY4R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  

    NPY5R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPY5R (see all 239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425592271,2
    --164263092(+) GCTTAA/TATTTG 1 -- us2k10--------
    rs601839001,2
    C--164263116(+) TCCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1819148601,2
    --164263155(+) TTCTTA/GATACT 1 -- us2k10--------
    rs1151007691,2
    --164263251(+) TAGCCA/CGGTTA 1 -- us2k10--------
    rs44751041,2
    C,F,H--164263286(+) GGTAGC/GCTTTT 1 -- us2k119Minor allele frequency- G:0.27NS EA NA WA CSA 2343
    rs100301181,2
    C,F,A,H--164263385(+) TTTTTA/TAATAC 1 -- us2k1 tfbs310Minor allele frequency- T:0.26NA WA CSA 254
    rs1505249761,2
    C--164263555(+) TAACCA/GCAGAG 1 -- us2k10--------
    rs1851980641,2
    --164263607(+) TCAAGA/GTCATC 1 -- us2k10--------
    rs1395161061,2
    C--164263770(+) TTAAAA/GGCTCT 1 -- us2k10--------
    rs99962271,2
    C,F,A,H--164263801(+) GAAATG/AGCAAT 1 -- us2k129Minor allele frequency- A:0.15NS EA NA WA CSA 2709

    HapMap Linkage Disequilibrium report for NPY5R (164265091 - 164273086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NPY5R:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000463CNV Loss20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY5R
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY5R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602001    OMIM disorders: --

    18 diseases for NPY5R:    
    About MalaCards
    papillon-lefevre disease    cocaine dependence    morbid obesity    panic disorder
    autism spectrum disorder    alcohol dependence    anorexia nervosa    pancreatitis
    obesity    neuroblastoma    atherosclerosis    retinitis
    parkinson's disease    endotheliitis    cerebritis    breast cancer
    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NPY5R:
    Papillon-Lefevre disease

    NPY5R for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NPY5R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 44.4 10 10849579 (2), 17083999 (1), 14987833 (1), 15358298 (1) (see all 9)
    dyslipidemia 0.853 1 17426313 (1)

    Genetic Association Database (GAD): NPY5R
    Human Genome Epidemiology (HuGE) Navigator: NPY5R (18 documents)

    Export disorders for NPY5R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPY5R gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with NPY5R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A receptor subtype involved in neuropeptide-Y-induced food intake. (PubMed id 8700207)1, 2, 3 Gerald C.... Weinshank R.L. (Nature 1996)
    2. Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. (PubMed id 17426313)1, 4, 9 Coletta D.K....Jenkinson C.P. (Obesity (Silver Spring) 2007)
    3. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. (PubMed id 8824284)1, 2, 9 Hu Y.... McCaleb M.L. (J. Biol. Chem. 1996)
    4. Novel neuropeptide Y1 and Y5 receptor gene variants: associations with serum triglyceride and high-density lipoprotein cholesterol levels. (PubMed id 12220433)1, 4, 9 Blumenthal J.B....Walston J.D. (Clin. Genet. 2002)
    5. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. (PubMed id 9169127)1, 2, 9 Herzog H.... Shine J. (Genomics 1997)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1, 4 Kim H.Y....Kim H. (BMB Rep 2010)
    8. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    9. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. (PubMed id 19077438)1, 4 Chung W.K....Tiwari H.K. (Hum. Hered. 2009)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4889 HGNC: 7958 AceView: NPY5R Ensembl:ENSG00000164129 euGenes: HUgn4889
    ECgene: NPY5R Kegg: 4889 H-InvDB: NPY5R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPY5R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPY5R gene:
    Search GeneIP for patents involving NPY5R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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