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Aliases for NPY5R Gene

Aliases for NPY5R Gene

  • Neuropeptide Y Receptor Y5 2 3 5
  • NPY-Y5 Receptor 3 4
  • Y5 Receptor 3 4
  • NPYY5-R 3 4
  • NPY5-R 3 4
  • NPYR5 3 4

External Ids for NPY5R Gene

Previous GeneCards Identifiers for NPY5R Gene

  • GC04P165118
  • GC04P164696
  • GC04P164842
  • GC04P164622
  • GC04P164484
  • GC04P164265
  • GC04P160019

Summaries for NPY5R Gene

Entrez Gene Summary for NPY5R Gene

  • The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for NPY5R Gene

NPY5R (Neuropeptide Y Receptor Y5) is a Protein Coding gene. Diseases associated with NPY5R include Neuroblastoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for NPY5R Gene

  • Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

Tocris Summary for NPY5R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY5R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY5R Gene

Genomics for NPY5R Gene

Regulatory Elements for NPY5R Gene

Enhancers for NPY5R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPY5R on UCSC Golden Path with GeneCards custom track

Genomic Location for NPY5R Gene

163,343,868 bp from pter
163,352,403 bp from pter
8,536 bases
Plus strand

Genomic View for NPY5R Gene

Genes around NPY5R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY5R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY5R Gene

Proteins for NPY5R Gene

  • Protein details for NPY5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 5
    Protein Accession:
    Secondary Accessions:
    • Q6GTR7
    • Q92916

    Protein attributes for NPY5R Gene

    445 amino acids
    Molecular mass:
    50727 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50623.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPY5R Gene

neXtProt entry for NPY5R Gene

Proteomics data for NPY5R Gene at MOPED

Post-translational modifications for NPY5R Gene

  • Glycosylation at Asn 10 and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY5R Gene

No data available for DME Specific Peptides for NPY5R Gene

Domains & Families for NPY5R Gene

Gene Families for NPY5R Gene

Suggested Antigen Peptide Sequences for NPY5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY5R: view

Function for NPY5R Gene

Molecular function for NPY5R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
genes like me logo Genes that share phenotypes with NPY5R: view

Animal Models for NPY5R Gene

MGI Knock Outs for NPY5R:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPY5R Gene

Localization for NPY5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPY5R Gene COMPARTMENTS Subcellular localization image for NPY5R gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for NPY5R Gene

Pathways & Interactions for NPY5R Gene

genes like me logo Genes that share pathways with NPY5R: view

SIGNOR curated interactions for NPY5R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 8824284
GO:0007218 neuropeptide signaling pathway IEA,TAS --
GO:0014050 negative regulation of glutamate secretion IEA --
genes like me logo Genes that share ontologies with NPY5R: view

Drugs & Compounds for NPY5R Gene

(31) Drugs for NPY5R Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AC162352 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0
[Ala<sup>31</sup>,Aib<sup>32</sup>]NPY (pig) Pharma Full agonist, Agonist 0
[D-Trp<sup>32</sup>]NPY Pharma Full agonist, Agonist 0
[Leu<sup>31</sup>,Pro<sup>34</sup>]NPY (pig) Pharma Full agonist, Agonist 0

(8) Additional Compounds for NPY5R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (human, rat)
[Leu31,Pro34]-Neuropeptide Y (porcine)
Neuropeptide Y (human, rat)
Neuropeptide Y (porcine)
Pancreatic Polypeptide (human)

(5) Tocris Compounds for NPY5R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist 132699-73-1
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Neuropeptide Y (porcine) Influences feeding and sexual behavior 83589-17-7
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2
genes like me logo Genes that share compounds with NPY5R: view

Transcripts for NPY5R Gene

mRNA/cDNA for NPY5R Gene

(11) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY5R Gene

No ASD Table

Relevant External Links for NPY5R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY5R Gene

mRNA expression in normal human tissues for NPY5R Gene

mRNA differential expression in normal tissues according to GTEx for NPY5R Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY5R Gene

SOURCE GeneReport for Unigene cluster for NPY5R Gene Hs.519058

mRNA Expression by UniProt/SwissProt for NPY5R Gene

Tissue specificity: Brain; hypothalamus.
genes like me logo Genes that share expression patterns with NPY5R: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NPY5R Gene

Orthologs for NPY5R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY5R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPY5R 35
  • 86.67 (n)
  • 90.56 (a)
NPY5R 36
  • 90 (a)
(Canis familiaris)
Mammalia NPY5R 35
  • 91.76 (n)
  • 94.83 (a)
NPY5R 36
  • 90 (a)
(Mus musculus)
Mammalia Npy5r 35
  • 84.98 (n)
  • 89.41 (a)
Npy5r 16
Npy5r 36
  • 85 (a)
(Pan troglodytes)
Mammalia NPY5R 35
  • 99.93 (n)
  • 100 (a)
NPY5R 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Npy5r 35
  • 84.23 (n)
  • 88.74 (a)
(Monodelphis domestica)
Mammalia NPY5R 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia NPY5R 36
  • 83 (a)
(Gallus gallus)
Aves NPY5R 35
  • 71.5 (n)
  • 70.29 (a)
NPY5R 36
  • 76 (a)
(Anolis carolinensis)
Reptilia NPY5R 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy5r 35
  • 69.21 (n)
  • 70.79 (a)
(Danio rerio)
Actinopterygii npy8br 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY2 35
  • 43.05 (n)
  • 31.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 35
  • 43.25 (n)
  • 33.99 (a)
NPFR1 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea npr-11 36
  • 22 (a)
npr-12 36
  • 23 (a)
Species with no ortholog for NPY5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY5R Gene

Gene Tree for NPY5R (if available)
Gene Tree for NPY5R (if available)

Paralogs for NPY5R Gene

genes like me logo Genes that share paralogs with NPY5R: view

Variants for NPY5R Gene

Sequence variations from dbSNP and Humsavar for NPY5R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4146927 -- 163,348,326(+) TAAAA(A/G)AACAT intron-variant
rs6842264 -- 163,348,453(+) GCCAG(A/G)CCCCA intron-variant
rs6858817 -- 163,352,424(+) GATAA(A/T)TTTTT downstream-variant-500B
rs7678265 -- 163,347,762(+) TCATG(C/T)GAGTC intron-variant
rs7679206 -- 163,348,082(+) TGAAC(G/T)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY5R Gene

Variant ID Type Subtype PubMed ID
esv1000463 CNV Loss 20482838

Variation tolerance for NPY5R Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NPY5R Gene

Disorders for NPY5R Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPY5R Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search NPY5R in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPY5R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPY5R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY5R Gene

Publications for NPY5R Gene

  1. A receptor subtype involved in neuropeptide-Y-induced food intake. (PMID: 8700207) Gerald C. … Weinshank R.L. (Nature 1996) 2 3 4 67
  2. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. (PMID: 20332211) Sheriff S. … Amlal H. (Mol. Cancer Res. 2010) 3 23
  3. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PMID: 19481128) Umeda T. … Iwaasa H. (Peptides 2009) 3 23
  4. Chromosome 4q31-34 panic disorder risk locus: association of neuropeptide Y Y5 receptor variants. (PMID: 17948870) Domschke K. … Deckert J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23
  5. Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. (PMID: 17426313) Coletta D.K. … Jenkinson C.P. (Obesity (Silver Spring) 2007) 3 23

Products for NPY5R Gene

Sources for NPY5R Gene