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Aliases & Descriptions for NPY5R
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| NPY5-R 3 | | NPYR5 1, 2, 3 | | NPYY5 3 |
| | | Descriptions |
|---|
| NPY-Y5 receptor 3 | | Y5 receptor 3 | | neuropeptide Y receptor Y5 2 |
|
| | Search outside databases for aliases for NPY5R genePrevious GC identifers: GC04P165118 GC04P164696 GC04P164842 GC04P164622 |
Summaries for NPY5R(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disordersGene Wiki entry for NPY5R (Neuropeptide_Y_receptor_Y5) |
Genomic Location for NPY5R
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NPY5R gene 
Entrez Gene cytogenetic band: 4q31-q32 Ensembl cytogenetic band: 4q32.2 HGNC cytogenetic band: 4q31-q32NPY5R Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P164484:
(about GC identifiers)
Start:
|
164,484,541 bp from pter |
End:
|
164,492,536 bp from pter |
Size:
|
7,996 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for NPY5R
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761 (See
protein sequence)Recommended Name: Neuropeptide Y receptor type 5 Size: 445 amino acids; 50727 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :2HE6 (3D)
 
Secondary accessions: Q6GTR7 Q92916REFSEQ proteins: NP_006165.1
ENSEMBL proteins: ENSP00000339377
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NPY5R: Assays for NPY5R: | Protein
Domains/ Families for NPY5R(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15761
ProtoNet protein and cluster: Q15761 2 Blocks protein families: IPB000393 Neuropeptide Y5 receptor signature IPB000611 Neuropeptide Y receptor signature
UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for NPY5R
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006174
Applied Biosystems Silencer® siRNAs for NPY5R
Sigma-Aldrich siRNA and siRNA Panels for NPY5R  Sigma-Aldrich shRNA Panels and shRNA for NPY5R  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006174                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006174                                  untagged cDNA clone in CMV expression vector: NM_006174 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006174
UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disordersGenatlas biochemistry entry for NPY5R:neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Npy5r):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001601 | peptide YY receptor activity |
IEA | -- | | GO:0001602 | pancreatic polypeptide receptor activity |
IEA | -- | | GO:0004872 | receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
IEA | -- | About this table | Pathways & Interactions for NPY5R
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for NPY5R (ENSP000003393773) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 8824284 | | GO:0007268 | synaptic transmission |
IEA | -- | About this table
|
Drugs & Compounds for NPY5R(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for NPY5R available from Tocris Bioscience About this table
8 Novoseek chemical compound relationships for NPY5R gene
About this table
|
Transcripts for NPY5R(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006174
Sigma-Aldrich siRNA and siRNA Panels for NPY5R  Sigma-Aldrich shRNA Panels and shRNA for NPY5R  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006174 REFSEQ mRNAs for NPY5R gene: NM_006174.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006174               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006174                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006174                                  untagged cDNA clone in CMV expression vector: NM_006174  Additional cDNA sequence: U56079.1 5 DOTS entries: DT.92416492 DT.106215 DT.99995306 DT.121236625 DT.92416494 11 AceView cDNA sequences:U56079 BC034224 U66275 BC042416 BI488524 NM_006174 U94320 BX461151 BE972691 BG191732 BG773165
highest scoring ESTs for NPY5R:U94320 BC034224 BC042416 BG431031 BI488524 U56079 U66275 BE972691 BI464162 BX451553 Unigene Clusters for NPY5R: Neuropeptide Y receptor Y5 Hs.519058 [show with all ESTs], Hs.598503 Unigene Representative Sequences: BC034224, U56079
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000338566
|
Expression for NPY5R
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NPY5R expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NPY5R
1 / 2 / 3 3 probe-sets matching NPY5R gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATGTCCTGTT
SOURCE GeneReport for Unigene clusters: Hs.519058 Hs.598503
Expression variation in blood from EXPOLDB for NPY5R UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761Tissue specificity: Brain; hypothalamus |
Orthologs for NPY5R
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NPY5R gene from 5 species
About this table Species with no ortholog for NPY5R
ENSEMBL Gene Tree for NPY5R | Paralogs for NPY5R(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NPY5R gene
- NPY1R2 NPY2R2 NPY6R2 PRLHR2 PPYR12
|
SNPs/Variants for NPY5R(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NPY5R (up to first 250kb)
|
Disorders & Mutations for NPY5R
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602001
2 Novoseek disease relationships for NPY5R gene
About this table
Genetic Association Database: NPY5R Human Genome Epidemiology Navigator: NPY5R (9 documents)
|
Medical News for NPY5R(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NPY5R (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/144 PubMed articles for NPY5R gene (see all 144
):- A receptor subtype involved in neuropeptide-Y-induced food intake. (PubMed id 8700207)2, 3, 4 Gerald C.... Weinshank R.L. (1996)
- Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. (PubMed id 8824284)1, 3, 4 Hu Y.... McCaleb M.L. (1996)
- Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. (PubMed id 9169127)1, 3, 4 Herzog H.... Shine J. (1997)
- Novel neuropeptide Y1 and Y5 receptor gene variants: associations with serum triglyceride and high-density lipoprotein cholesterol levels. (PubMed id 12220433)1, 3, 6 Blumenthal J.B....Walston J.D. (2002)
- Genotype analysis of the neuropeptide Y (NPY) Y1 and NPY Y5 receptor genes in gonadotropin-releasing hormone-dependent precocious gonadarche. (PubMed id 15302312)3, 6 Barker-Gibb M....Witchel S.F. (2004)
- Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PubMed id 9417917)2, 3 Lutz C.M....Thompson D.A. (1997)
- Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. (PubMed id 16891622)1, 3 Movafagh S....Zukowska Z. (2006)
- Chromosome 4q31-34 panic disorder risk locus: association of neuropeptide Y Y5 receptor variants. (PubMed id 17948870)1, 3 Domschke K....Deckert J. (2008)
- Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. (PubMed id 17426313)1, 3 Coletta D.K....Jenkinson C.P. (2007)
- Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform. (PubMed id 12398768)1, 3 Rodriguez M....Galizzi J.P. (2003)
|
Search for NPY5R
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NPY5R
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NPY5R
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPY5R(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NPY5R(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NPY5R:

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| | | | Tocris compounds for NPY5R |
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Incremental update: 13 Oct 2009
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