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Aliases for NPY5R Gene

Aliases for NPY5R Gene

  • Neuropeptide Y Receptor Y5 2 3
  • NPY-Y5 Receptor 3 4
  • Y5 Receptor 3 4
  • NPYY5-R 3 4
  • NPY5-R 3 4
  • NPYR5 3 4

External Ids for NPY5R Gene

Previous GeneCards Identifiers for NPY5R Gene

  • GC04P165118
  • GC04P164696
  • GC04P164842
  • GC04P164622
  • GC04P164484
  • GC04P164265
  • GC04P160019

Summaries for NPY5R Gene

Entrez Gene Summary for NPY5R Gene

  • The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for NPY5R Gene

NPY5R (Neuropeptide Y Receptor Y5) is a Protein Coding gene. Diseases associated with NPY5R include neuroblastoma and obesity. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY5R Gene

  • Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders

Tocris Summary for NPY5R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY5R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY5R Gene

Genomics for NPY5R Gene

Regulatory Elements for NPY5R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY5R Gene

Chromosome:
4
Start:
163,343,868 bp from pter
End:
163,352,403 bp from pter
Size:
8,536 bases
Orientation:
Plus strand

Genomic View for NPY5R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY5R Gene

Proteins for NPY5R Gene

  • Protein details for NPY5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15761-NPY5R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 5
    Protein Accession:
    Q15761
    Secondary Accessions:
    • Q6GTR7
    • Q92916

    Protein attributes for NPY5R Gene

    Size:
    445 amino acids
    Molecular mass:
    50727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50623.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPY5R Gene

neXtProt entry for NPY5R Gene

Proteomics data for NPY5R Gene at MOPED

Post-translational modifications for NPY5R Gene

  • Glycosylation at Asn 10 and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY5R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPY5R Gene

Domains & Families for NPY5R Gene

Gene Families for NPY5R Gene

Suggested Antigen Peptide Sequences for NPY5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15761

UniProtKB/Swiss-Prot:

NPY5R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY5R: view

Function for NPY5R Gene

Molecular function for NPY5R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders

Gene Ontology (GO) - Molecular Function for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 8824284
genes like me logo Genes that share ontologies with NPY5R: view
genes like me logo Genes that share phenotypes with NPY5R: view

Animal Models for NPY5R Gene

MGI Knock Outs for NPY5R:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY5R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NPY5R Gene

Localization for NPY5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPY5R Gene COMPARTMENTS Subcellular localization image for NPY5R gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8824284
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY5R: view

Pathways & Interactions for NPY5R Gene

genes like me logo Genes that share pathways with NPY5R: view

Pathways by source for NPY5R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for NPY5R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8824284
genes like me logo Genes that share ontologies with NPY5R: view

Drugs & Compounds for NPY5R Gene

(31) Drugs for NPY5R Gene - From: IUPHAR, DGIdb, NovoSeek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 1708
Isoniazid Approved Pharma 133
Morphine Approved, Investigational Pharma Partial agonist, Agonist 805
Acetylcholine Experimental Pharma Full agonist, Agonist 104
Benzimidazole Experimental Pharma 4

(8) Additional Compounds for NPY5R Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (porcine)
125580-28-1
BIBP 3226 trifluoroacetate
1068148-47-9
GR 231118
158859-98-4
Neuropeptide Y (human, rat)
90880-35-6
Pancreatic Polypeptide (human)
75976-10-2
genes like me logo Genes that share compounds with NPY5R: view

Transcripts for NPY5R Gene

mRNA/cDNA for NPY5R Gene

(9) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY5R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY5R Gene

No ASD Table

Relevant External Links for NPY5R Gene

GeneLoc Exon Structure for
NPY5R
ECgene alternative splicing isoforms for
NPY5R

Expression for NPY5R Gene

mRNA expression in normal human tissues for NPY5R Gene

mRNA differential expression in normal tissues according to GTEx for NPY5R Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY5R Gene



SOURCE GeneReport for Unigene cluster for NPY5R Gene Hs.519058

mRNA Expression by UniProt/SwissProt for NPY5R Gene

Q15761-NPY5R_HUMAN
Tissue specificity: Brain; hypothalamus
genes like me logo Genes that share expression patterns with NPY5R: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NPY5R Gene

Orthologs for NPY5R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY5R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPY5R 35
  • 86.67 (n)
  • 90.56 (a)
NPY5R 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY5R 35
  • 91.76 (n)
  • 94.83 (a)
NPY5R 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npy5r 35
  • 84.98 (n)
  • 89.41 (a)
Npy5r 16
Npy5r 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPY5R 35
  • 99.93 (n)
  • 100 (a)
NPY5R 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npy5r 35
  • 84.23 (n)
  • 88.74 (a)
oppossum
(Monodelphis domestica)
Mammalia NPY5R 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY5R 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPY5R 35
  • 71.5 (n)
  • 70.29 (a)
NPY5R 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY5R 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy5r 35
  • 69.21 (n)
  • 70.79 (a)
zebrafish
(Danio rerio)
Actinopterygii npy8br 36
  • 27 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY2 35
  • 43.05 (n)
  • 31.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 35
  • 43.25 (n)
  • 33.99 (a)
NPFR1 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-11 36
  • 22 (a)
ManyToMany
npr-12 36
  • 23 (a)
ManyToMany
Species with no ortholog for NPY5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY5R Gene

ENSEMBL:
Gene Tree for NPY5R (if available)
TreeFam:
Gene Tree for NPY5R (if available)

Paralogs for NPY5R Gene

genes like me logo Genes that share paralogs with NPY5R: view

Variants for NPY5R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY5R Gene

Variant ID Type Subtype PubMed ID
esv1000463 CNV Loss 20482838

Variation tolerance for NPY5R Gene

Residual Variation Intolerance Score: 12.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY5R Gene

HapMap Linkage Disequilibrium report
NPY5R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NPY5R Gene

Disorders for NPY5R Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPY5R Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
obesity
  • obesity, association with
- elite association
Search NPY5R in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPY5R

Genetic Association Database (GAD)
NPY5R
Human Genome Epidemiology (HuGE) Navigator
NPY5R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY5R
genes like me logo Genes that share disorders with NPY5R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY5R Gene

Publications for NPY5R Gene

  1. Are plasma ghrelin and PYY concentrations associated with obesity-related depression? (PMID: 20464703) Olszanecka-Glinianowicz M. … Zahorska-Markiewicz B. (Endokrynol Pol 2010) 23 67
  2. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. (PMID: 20332211) Sheriff S. … Amlal H. (Mol. Cancer Res. 2010) 23 67
  3. Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. (PMID: 19233647) Sato N. … Fukami T. (Bioorg. Med. Chem. Lett. 2009) 23 67
  4. Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect. (PMID: 19459652) Sato N. … Fukami T. (J. Med. Chem. 2009) 23 67
  5. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PMID: 19481128) Umeda T. … Iwaasa H. (Peptides 2009) 23 67

Products for NPY5R Gene

Sources for NPY5R Gene

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