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NPY5R Gene

protein-coding   GIFtS: 62

GC04P164484
neuropeptide Y receptor Y5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
NPY5-R 3
NPYR5 1, 2, 3
NPYY5 3
Descriptions
NPY-Y5 receptor 3
Y5 receptor 3
neuropeptide Y receptor Y5 2
External Ids
HGNC: 79581
Entrez Gene: 48892
UniProtKB: Q157613
Ensembl: ENSG000001641297
Search outside databases for aliases for NPY5R gene

Previous GC identifers: GC04P165118 GC04P164696 GC04P164842 GC04P164622

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by
G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could
be involved in feeding disorders

Gene Wiki entry for NPY5R (Neuropeptide_Y_receptor_Y5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NPY5R gene  

Entrez Gene cytogenetic band: 4q31-q32   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q31-q32

NPY5R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P164484:     (about GC identifiers)

Start:
164,484,541 bp from pter
End:
164,492,536 bp from pter
Size:
7,996 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 5  
Size: 445 amino acids; 50727 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
2HE6 (3D)    
Secondary accessions: Q6GTR7 Q92916

REFSEQ proteins: NP_006165.1  

ENSEMBL proteins: 
ENSP00000339377 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (NPY5R)
Human Recombinant Proteins from Abnova (NPY5R)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0005887 integral to plasma membrane TAS8824284
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Antibodies for NPY5R: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of NPY5R
Sigma-Aldrich Antibodies for NPY5R
Browse R&D Systems for Antibodies
Antibodies from Abcam (NPY5R), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NPY5R)
Novus Biologicals Antibodies for NPY5R

Assays for NPY5R: 
Invitrogen Assays for NPY5R
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000393 NPY5_rcpt
 IPR000276 7TM_GPCR_Rhodpsn
 IPR000611 NPY_rcpt


   GeneDecks  NPY5R for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q15761

ProtoNet protein and cluster: Q15761

2 Blocks protein families:
IPB000393 Neuropeptide Y5 receptor signature
IPB000611 Neuropeptide Y receptor signature


UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NPY5R)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NPY5R)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006174

              Applied Biosystems Silencer® siRNAs for NPY5R

              Sigma-Aldrich siRNA and siRNA Panels for NPY5R  
                     Sigma-Aldrich shRNA Panels and shRNA for NPY5R  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for NPY5R
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006174
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006174
                                 untagged cDNA clone in CMV expression vector: NM_006174 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006174

UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by
G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could
be involved in feeding disorders

Genatlas biochemistry entry for NPY5R:
neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor
superfamily

5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Npy5r):

adipose tissuebehavior/neurologicalgrowth/sizehomeostasis/metabolismliver/biliary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001601 peptide YY receptor activity IEA--
GO:0001602 pancreatic polypeptide receptor activity IEA--
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for NPY5R (Maps provided by GeneGo):
 Gi-a specific GPCRs (in brain)

   GeneDecks  NPY5R for the pathways selected above  
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1 Millipore Pathway for NPY5R
 Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

   GeneDecks  NPY5R for the pathways selected above  
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1 Kegg Pathway  (Kegg details for NPY5R):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  NPY5R for the pathways selected above  
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5/7 Interacting proteins for NPY5R (ENSP000003393773) via UniProtKB, MINT, and/or STRING (see all 7 )
InteractantInteraction Details
GeneCardExternal ID(s)
NPYENSP000002421523STRING (score=.997)
PYYENSP000003531983STRING (score=.994)
PPYENSP000002259923STRING (score=.968)
NPY2RENSP000003325913STRING (score=.921)
PPYR1ENSP000003634313STRING (score=.92)
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway TAS8824284
GO:0007268 synaptic transmission IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for NPY5R available from Tocris Bioscience
CompoundAction CAS number
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic PolypeptidePotent, selective neuropeptide Y Y5 agonist
CGP 71683 hydrochlorideHighly selective and potent non-peptide NPY Y5 receptor antagonist[192322-50-2]
NTNCB hydrochloridePotent and selective non-peptidic Y5 antagonist[486453-65-0]
BWX 46Highly selective Y5 agonist[172997-92-1]
L-152,804Potent, selective non-peptide NPY Y5 antagonist[6508-43-6]
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8 Novoseek chemical compound relationships for NPY5R gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
biie0246 69.06 1 17265460 (1)
lead 25.78 2 11858996 (1), 18752943 (1)
cyclic amp 18.00 1 15771450 (1)
calcium 0.27 5 14599717 (2), 10872822 (1), 9854049 (1)
forskolin 0.00 1 10737676 (1)
sodium 0.00 1 11390018 (1)
glucose 0.00 3 9607814 (2), 10203865 (1)
ethanol 0.00 4 16377459 (2), 12626767 (1)
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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NPY5R)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NPY5R)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006174

              Sigma-Aldrich siRNA and siRNA Panels for NPY5R  
                     Sigma-Aldrich shRNA Panels and shRNA for NPY5R  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006174  

REFSEQ mRNAs for NPY5R gene: 

NM_006174.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006174  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006174
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006174
                                 untagged cDNA clone in CMV expression vector: NM_006174 

Additional cDNA sequence: U56079.1 

5 DOTS entries:

DT.92416492  DT.106215  DT.99995306  DT.121236625  DT.92416494 

11 AceView cDNA sequences:

U56079 BC034224 U66275 BC042416 BI488524 NM_006174 U94320 BX461151 
BE972691 BG191732 BG773165 

highest scoring ESTs for NPY5R:

U94320 BC034224 BC042416 BG431031 BI488524 U56079 U66275 BE972691 BI464162 BX451553 

Unigene Clusters for NPY5R:

Neuropeptide Y receptor Y5
Hs.519058  [show with all ESTs], Hs.598503
Unigene Representative Sequences: BC034224, U56079


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000338566  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NPY5R expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NPY5R

1 / 2 / 3

3 probe-sets matching NPY5R gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

33100_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U94320 1.00 1.00 1.00 1

207400_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006174 0.60 1.00 0.82 1

207400_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ATGTCCTGTT

SOURCE GeneReport for Unigene clusters: Hs.519058 Hs.598503

Expression variation in blood from EXPOLDB for NPY5R

UniProtKB/Swiss-Prot: NPY5R_HUMAN, Q15761
Tissue specificity: Brain; hypothalamus

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for NPY5R gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
NPY5R1   -- neuropeptide Y receptor Y5 91.76(n)
94.83(a)
403712  NM_001003118.1  NP_001003118.1 
chimpanzee
(Pan troglodytes)
NPY5R1   -- neuropeptide Y receptor Y5 99.93(n)
100(a)
461582  XM_001148465.1  XP_001148465.1 
rat
(Rattus norvegicus)
Npy5r1   -- neuropeptide Y receptor Y5 84.23(n)
88.74(a)
25340  NM_012869.1  NP_037001.1 
mouse
(Mus musculus)
Npy5r1, 5 8 (32.50 cM)5
neuropeptide Y receptor Y51, 5 84.91(n)1
89.19(a)1
181681  NM_016708.21  NP_057917.11 
 AB0013465  AF0229485  (see all 13)
chicken
(Gallus gallus)
NPY5R1   -- neuropeptide Y receptor Y5 71.61(n)
70.78(a)
422419  NM_001031130.1  NP_001026301.1 
About this table        Species with no ortholog for NPY5R

ENSEMBL Gene Tree for NPY5R
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for NPY5R gene
NPY1R2  NPY2R2  NPY6R2  PRLHR2  PPYR12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/72 NCBI SNPs in NPY5R are shown (see all 72 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs125126871,2
C,F,H164492646(+) CCATAG/AGCTTC 1 -- ng316Minor allele frequency- A:0.11EU EA WA NA 602
rs99962271,2
A,C,H164483251(+) GAAATG/AGCAAT 1 -- ng516Minor allele frequency- A:0.08EA NA 522
rs44751041,2
C,F,H164482736(+) GGTAGG/CCTTTT 1 -- ng514Minor allele frequency- C:0.26EU EA WA 420
rs68588171,2
F,H164493026(+) GATAAT/ATTTTT 1 -- ng314Minor allele frequency- A:0.41EU EA WA 390
--
rs100301181,2
A,C164482835(+) TTTTTA/TAATAC 1 -- ng51 tfbs30--------
--
rs43142401,2
C164484226(+) GGTTGA/GGGGCT 1 -- ng510--------
rs125033651,2
H164486353(+) GGGAAA/GGGGTA 1 -- ut51 trp34Minor allele frequency- G:0.00EU EA WA 388
rs39677671,2
H164490987(+) GTGTAG/AATGAC 1 N/D mis1 ese34Minor allele frequency- A:0.00EU EA WA 404
--
rs119460041,2
C164492153(+) TATGGA/GTTTCT 1 G/G syn1 ese30--------
rs111004941,2
A,C,F,H164489703(+) TCCAGC/AATTGC 1 -- int14Minor allele frequency- A:0.11EU EA WA 418
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HapMap Linkage Disequilibrium images for NPY5R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602001

2 Novoseek disease relationships for NPY5R gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
obesity 45.38 10 10849579 (2), 17083999 (1), 14987833 (1), 15358298 (1) (see all 9)
dyslipidemia 3.65 1 17426313 (1)
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Genetic Association Database: NPY5R
Human Genome Epidemiology Navigator: NPY5R (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/144 PubMed articles for NPY5R gene (see all 144 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4889 HGNC: 7958 AceView: NPY5R Ensembl:ENSG00000164129 euGenes: HUgn4889
ECgene: NPY5R H-InvDB: NPY5R
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for NPY5R:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for NPY5R Antibodies for NPY5R
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for NPY5R Browse small molecules at Sigma-Aldrich
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 Tocris compounds for NPY5R




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for NPY5R

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