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Aliases for NPY5R Gene

Aliases for NPY5R Gene

  • Neuropeptide Y Receptor Y5 2 3
  • NPY-Y5 Receptor 3 4
  • Y5 Receptor 3 4
  • NPYY5-R 3 4
  • NPY5-R 3 4
  • NPYR5 3 4
  • Neuropeptide Y Receptor Type 5 3

External Ids for NPY5R Gene

Summaries for NPY5R Gene

GeneCards Summary for NPY5R Gene

NPY5R (Neuropeptide Y Receptor Y5) is a Protein Coding gene. Diseases associated with NPY5R include obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide Y receptor activity and pancreatic polypeptide receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY5R Gene

  • Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders

Tocris Summary for NPY5R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY5R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY5R Gene

Genomics for NPY5R Gene

Genomic Location for NPY5R Gene

163,343,910 bp from pter
163,352,388 bp from pter
8,479 bases
Plus strand

Genomic View for NPY5R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY5R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY5R Gene

Regulatory Elements for NPY5R Gene

Proteins for NPY5R Gene

  • Protein details for NPY5R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 5
    Protein Accession:
    Secondary Accessions:
    • Q6GTR7
    • Q92916

    Protein attributes for NPY5R Gene

    445 amino acids
    Molecular mass:
    50727 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50623.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPY5R Gene

neXtProt entry for NPY5R Gene

Proteomics data for NPY5R Gene at MOPED

Post-translational modifications for NPY5R Gene

Other Protein References for NPY5R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPY5R Gene

Domains for NPY5R Gene

Gene Families for NPY5R Gene

  • NPYR :GPCR / Class A : Neuropeptide receptors : Y

Suggested Antigen Peptide Sequences for NPY5R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.:
    • Q15761
genes like me logo Genes that share domains with NPY5R: view

Function for NPY5R Gene

Molecular function for NPY5R Gene

GENATLAS Biochemistry: neuropeptide Y receptor Y5,overlapping NPY1R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders

Gene Ontology (GO) - Molecular Function for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 8824284
genes like me logo Genes that share ontologies with NPY5R: view
genes like me logo Genes that share phenotypes with NPY5R: view

Animal Models for NPY5R Gene

MGI Knock Outs for NPY5R:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NPY5R Gene

Localization for NPY5R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY5R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPY5R Gene COMPARTMENTS Subcellular localization image for NPY5R gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8824284
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY5R: view

Pathways for NPY5R Gene

genes like me logo Genes that share pathways with NPY5R: view

Pathways by source for NPY5R Gene

Gene Ontology (GO) - Biological Process for NPY5R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007186 G-protein coupled receptor signaling pathway TAS 8824284
GO:0007218 neuropeptide signaling pathway TAS 8824284
genes like me logo Genes that share ontologies with NPY5R: view

Compounds for NPY5R Gene

(5) Tocris Compounds for NPY5R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist [132699-73-1]
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist [159013-54-4]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]

(17) IUPHAR Ligand for NPY5R Gene

Ligand Type Action Affinity Pubmed IDs
[Leu31,Pro34]NPY (pig) Agonist Full agonist 9.1
neuropeptide Y Agonist Full agonist 9.1
NPY-(2-36) Agonist Full agonist 8.9
peptide YY Agonist Full agonist 8.9
[Leu31,Pro34]PYY (human) Agonist Full agonist 8.8
[PP1-17,Ala31,Aib32]NPY (human) Agonist Full agonist 8.8
FMS586 Antagonist Antagonist 8.4
[Ala31,Aib32]NPY (pig) Agonist Full agonist 8.2
[D-Trp32]NPY Agonist Full agonist 8.1
NPY-(3-36) (pig) Agonist Full agonist 8
PYY-(3-36) Agonist Full agonist 8
pancreatic polypeptide Agonist Full agonist 8
pancreatic polypeptide Agonist Full agonist 8
L-152,804 Antagonist Antagonist 7.6
NPY-(13-36) (pig) Agonist Full agonist 7.3
PYY-(13-36) (mouse, rat, pig) Agonist Full agonist 7.1
NPY-(18-36) (human, pig) Agonist Full agonist 6.2

(15) Novoseek inferred chemical compound relationships for NPY5R Gene

Compound -log(P) Hits PubMed IDs
bibp3226 75.2 3
biie0246 68.3 1
benzimidazole 31.6 2
cyclic amp 24.1 2
lead 24 2
genes like me logo Genes that share compounds with NPY5R: view

Transcripts for NPY5R Gene

mRNA/cDNA for NPY5R Gene

(9) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY5R Gene

No ASD Table

Relevant External Links for NPY5R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY5R Gene

mRNA expression in normal human tissues for NPY5R Gene

mRNA differential expression in normal tissues according to GTEx for NPY5R Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPY5R Gene

SOURCE GeneReport for Unigene cluster for NPY5R Gene Hs.519058

mRNA Expression by UniProt/SwissProt for NPY5R Gene

Tissue specificity: Brain; hypothalamus
genes like me logo Genes that share expressions with NPY5R: view

Orthologs for NPY5R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY5R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY5R 35
  • 99.93 (n)
  • 100 (a)
NPY5R 36
  • 100 (a)
(Bos Taurus)
Mammalia NPY5R 35
  • 86.67 (n)
  • 90.56 (a)
NPY5R 36
  • 90 (a)
(Canis familiaris)
Mammalia NPY5R 35
  • 91.76 (n)
  • 94.83 (a)
NPY5R 36
  • 90 (a)
(Mus musculus)
Mammalia Npy5r 35
  • 84.98 (n)
  • 89.41 (a)
Npy5r 16
Npy5r 36
  • 85 (a)
(Monodelphis domestica)
Mammalia NPY5R 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia NPY5R 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Npy5r 35
  • 84.23 (n)
  • 88.74 (a)
(Gallus gallus)
Aves NPY5R 35
  • 71.5 (n)
  • 70.29 (a)
NPY5R 36
  • 76 (a)
(Anolis carolinensis)
Reptilia NPY5R 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy5r 35
  • 69.21 (n)
  • 70.79 (a)
(Danio rerio)
Actinopterygii npy8br 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY2 35
  • 43.05 (n)
  • 31.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 35
  • 43.25 (n)
  • 33.99 (a)
NPFR1 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea npr-11 36
  • 22 (a)
npr-12 36
  • 23 (a)
Species with no ortholog for NPY5R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY5R Gene

Gene Tree for NPY5R (if available)
Gene Tree for NPY5R (if available)

Paralogs for NPY5R Gene

genes like me logo Genes that share paralogs with NPY5R: view

Variants for NPY5R Gene

Sequence variations from dbSNP and Humsavar for NPY5R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3967767 -- 163,350,385(+) GTGTA(A/G)ATGAC missense, reference
rs4146927 -- 163,348,326(+) TAAAA(A/G)AACAT intron-variant
rs6842264 -- 163,348,453(+) GCCAG(A/G)CCCCA intron-variant
rs6858817 -- 163,352,424(+) GATAA(A/T)TTTTT downstream-variant-500B
rs7678265 -- 163,347,762(+) TCATG(C/T)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY5R Gene

Variant ID Type Subtype PubMed ID
esv1000463 CNV Loss 20482838

Relevant External Links for NPY5R Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY5R Gene

Disorders for NPY5R Gene

(1) MalaCards Diseases for NPY5R Gene

Search for NPY5R Gene in MalaCards »

(1) University of Copenhagen DISEASES for NPY5R Gene

(2) Novoseek inferred disease relationships for NPY5R Gene

Disease -log(P) Hits PubMed IDs
obesity 44.4 10
dyslipidemia 0.853 1

Relevant External Links for NPY5R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPY5R: view

No data available for UniProtKB/Swiss-Prot for NPY5R Gene

Publications for NPY5R Gene

  1. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. (PMID: 8824284) Hu Y. … McCaleb M.L. (J. Biol. Chem. 1996) 3 4 23
  2. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. (PMID: 9169127) Herzog H. … Shine J. (Genomics 1997) 3 4 23
  3. Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans. (PMID: 17426313) Coletta D.K. … Jenkinson C.P. (Obesity (Silver Spring) 2007) 3 23 48
  4. A receptor subtype involved in neuropeptide-Y-induced food intake. (PMID: 8700207) Gerald C. … Weinshank R.L. (Nature 1996) 2 3 4
  5. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz C.M. … Thompson D.A. (Genomics 1997) 2 3

Products for NPY5R Gene

Sources for NPY5R Gene

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