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Aliases for NPY4R Gene

Aliases for NPY4R Gene

  • Neuropeptide Y Receptor Y4 2 3
  • Pancreatic Polypeptide Receptor 1 2 3 4
  • PPYR1 3 4 6
  • PP1 3 4 6
  • NPY4-R 3 4
  • Neuropeptide Y Receptor Type 4 3
  • Y4 3

External Ids for NPY4R Gene

Previous Symbols for NPY4R Gene

  • PPYR1

Summaries for NPY4R Gene

GeneCards Summary for NPY4R Gene

NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY4R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Tocris Summary for NPY4R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY4R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY4R Gene

Genomics for NPY4R Gene

Genomic Location for NPY4R Gene

Start:
46,461,099 bp from pter
End:
46,465,881 bp from pter
Size:
4,783 bases
Orientation:
Minus strand

Genomic View for NPY4R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R Gene

No data available for Regulatory Elements for NPY4R Gene

Proteins for NPY4R Gene

  • Protein details for NPY4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50391-NPY4R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 4
    Protein Accession:
    P50391
    Secondary Accessions:
    • Q13456
    • Q5ISU3
    • Q5T2X9
    • Q6FH06

    Protein attributes for NPY4R Gene

    Size:
    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY4R Gene

neXtProt entry for NPY4R Gene

Proteomics data for NPY4R Gene at MOPED

Post-translational modifications for NPY4R Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn2, Asn19, Asn29, and Asn187

Other Protein References for NPY4R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPY4R Gene

Domains for NPY4R Gene

Gene Families for NPY4R Gene

HGNC:
  • NPYR :GPCR / Class A : Neuropeptide receptors : Y

UniProtKB/Swiss-Prot:

NPY4R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P50391
genes like me logo Genes that share domains with NPY4R: view

Function for NPY4R Gene

Molecular function for NPY4R Gene

UniProtKB/Swiss-Prot Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Gene Ontology (GO) - Molecular Function for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 8643460
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with NPY4R: view
genes like me logo Genes that share phenotypes with NPY4R: view

Animal Models for NPY4R Gene

MGI Knock Outs for NPY4R:

miRNA for NPY4R Gene

miRTarBase miRNAs that target NPY4R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPY4R Gene

Localization for NPY4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8643460
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY4R: view

Pathways for NPY4R Gene

genes like me logo Genes that share pathways with NPY4R: view

Pathways by source for NPY4R Gene

Interacting Proteins for NPY4R Gene

Gene Ontology (GO) - Biological Process for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007586 digestion TAS 7592911
GO:0007631 feeding behavior TAS 7592911
GO:0008015 blood circulation TAS 7592911
genes like me logo Genes that share ontologies with NPY4R: view

Compounds for NPY4R Gene

(5) Tocris Compounds for NPY4R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist [132699-73-1]
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist [159013-54-4]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]

(25) Novoseek inferred chemical compound relationships for NPY4R Gene

Compound -log(P) Hits PubMed IDs
bibo3304 81.5 2
calyculin a 76.8 12
okadaic acid 75 24
tautomycin 69.5 3
threonine 65.6 20
genes like me logo Genes that share compounds with NPY4R: view

Transcripts for NPY4R Gene

mRNA/cDNA for NPY4R Gene

(12) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R Gene

No ASD Table

Relevant External Links for NPY4R Gene

GeneLoc Exon Structure for
NPY4R
ECgene alternative splicing isoforms for
NPY4R

Expression for NPY4R Gene

mRNA expression in normal human tissues for NPY4R Gene

mRNA differential expression in normal tissues according to GTEx for NPY4R Gene

This gene is overexpressed in Colon - Transverse (14.8) and Colon - Sigmoid (7.2).

mRNA Expression by UniProt/SwissProt for NPY4R Gene

P50391-NPY4R_HUMAN
Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine
genes like me logo Genes that share expressions with NPY4R: view

Orthologs for NPY4R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPY4R 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPYR1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY4R 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npy4r 37
  • 75 (a)
OneToOne
Ppyr1 16
oppossum
(Monodelphis domestica)
Mammalia NPY4R 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY4R 37
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPYR1 36
  • 64.44 (n)
  • 60.28 (a)
PPYR1 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY4R 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy4r 36
  • 59.69 (n)
  • 53.3 (a)
zebrafish
(Danio rerio)
Actinopterygii npy4r 37
  • 46 (a)
OneToOne
npy8ar 36
  • 58.81 (n)
  • 53.73 (a)
npyryc 36
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 37
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-11 37
  • 26 (a)
ManyToMany
npr-12 36
  • 41.78 (n)
  • 31.6 (a)
npr-12 37
  • 23 (a)
ManyToMany
Species with no ortholog for NPY4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY4R Gene

ENSEMBL:
Gene Tree for NPY4R (if available)
TreeFam:
Gene Tree for NPY4R (if available)

Paralogs for NPY4R Gene

Selected SIMAP similar genes for NPY4R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY4R: view

Variants for NPY4R Gene

Sequence variations from dbSNP and Humsavar for NPY4R Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7085859 -- 46,465,880(-) CCCTG(A/G)GCACA utr-variant-5-prime
rs7901924 -- 46,467,273(-) aagtt(C/G)ctcaa upstream-variant-2KB
rs7905256 -- 46,467,156(-) ACAAA(C/T)GGCAG upstream-variant-2KB
rs7905263 -- 46,467,150(-) GGCAG(C/T)TGCCA upstream-variant-2KB
rs7909805 -- 46,465,999(-) AAGGG(A/G)CAGGC upstream-variant-2KB

Relevant External Links for NPY4R Gene

HapMap Linkage Disequilibrium report
NPY4R

No data available for Structural Variations from Database of Genomic Variants (DGV) for NPY4R Gene

Disorders for NPY4R Gene

(1) Novoseek inferred disease relationships for NPY4R Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 32.1 2
genes like me logo Genes that share disorders with NPY4R: view

No data available for UniProtKB/Swiss-Prot for NPY4R Gene

Publications for NPY4R Gene

  1. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz C.M. … Thompson D.A. (Genomics 1997) 2 3 23
  2. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PMID: 7592911) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1995) 3 4 23
  3. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. (PMID: 7493937) Lundell I. … Larhammar D. (J. Biol. Chem. 1995) 3 4
  4. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PMID: 8643460) Yan H. … Karbon W. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NPY4R Gene

Sources for NPY4R Gene

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