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Aliases for NPY4R Gene

Aliases for NPY4R Gene

  • Neuropeptide Y Receptor Y4 2 3 5
  • Pancreatic Polypeptide Receptor 1 2 3 4
  • NPY4-R 3 4
  • PPYR1 3 4
  • PP1 3 4
  • Y4 3

External Ids for NPY4R Gene

Previous HGNC Symbols for NPY4R Gene

  • PPYR1

Previous GeneCards Identifiers for NPY4R Gene

  • GC10P047084

Summaries for NPY4R Gene

GeneCards Summary for NPY4R Gene

NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for NPY4R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Wiki entry for NPY4R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY4R Gene

Genomics for NPY4R Gene

Regulatory Elements for NPY4R Gene

Enhancers for NPY4R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPY4R on UCSC Golden Path with GeneCards custom track

Genomic Location for NPY4R Gene

46,458,551 bp from pter
46,470,647 bp from pter
12,097 bases
Minus strand

Genomic View for NPY4R Gene

Genes around NPY4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R Gene

Proteins for NPY4R Gene

  • Protein details for NPY4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 4
    Protein Accession:
    Secondary Accessions:
    • Q13456
    • Q5ISU3
    • Q5T2X9
    • Q6FH06

    Protein attributes for NPY4R Gene

    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY4R Gene

neXtProt entry for NPY4R Gene

Proteomics data for NPY4R Gene at MOPED

Post-translational modifications for NPY4R Gene

  • Glycosylation at Asn 2, Asn 19, Asn 29, and Asn 187
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY4R Gene

No data available for DME Specific Peptides for NPY4R Gene

Domains & Families for NPY4R Gene

Gene Families for NPY4R Gene

Suggested Antigen Peptide Sequences for NPY4R Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R: view

Function for NPY4R Gene

Molecular function for NPY4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
genes like me logo Genes that share phenotypes with NPY4R: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY4R

miRNA for NPY4R Gene

miRTarBase miRNAs that target NPY4R

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPY4R Gene

Localization for NPY4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R Gene

Cell membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NPY4R Gene

Pathways & Interactions for NPY4R Gene

genes like me logo Genes that share pathways with NPY4R: view

Interacting Proteins for NPY4R Gene

SIGNOR curated interactions for NPY4R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS 7592911
genes like me logo Genes that share ontologies with NPY4R: view

Drugs & Compounds for NPY4R Gene

(22) Drugs for NPY4R Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AC162352 Investigational Pharma Target 0
TM30338 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0
TM30339 Pharma agonist 0

(13) Additional Compounds for NPY4R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (human, rat)
[Leu31,Pro34]-Neuropeptide Y (porcine)
Neuropeptide Y (human, rat)
Neuropeptide Y (porcine)
Pancreatic Polypeptide (human)

(5) Tocris Compounds for NPY4R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist 132699-73-1
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Neuropeptide Y (porcine) Influences feeding and sexual behavior 83589-17-7
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2
genes like me logo Genes that share compounds with NPY4R: view

Transcripts for NPY4R Gene

mRNA/cDNA for NPY4R Gene

(12) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R Gene

No ASD Table

Relevant External Links for NPY4R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY4R Gene

mRNA expression in normal human tissues for NPY4R Gene

mRNA differential expression in normal tissues according to GTEx for NPY4R Gene

This gene is overexpressed in Colon - Transverse (x14.8) and Colon - Sigmoid (x7.2).

mRNA Expression by UniProt/SwissProt for NPY4R Gene

Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.
genes like me logo Genes that share expression patterns with NPY4R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY4R Gene

Orthologs for NPY4R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPYR1 36
  • 86 (a)
(Canis familiaris)
Mammalia NPY4R 36
  • 86 (a)
(Monodelphis domestica)
Mammalia NPY4R 36
  • 64 (a)
(Mus musculus)
Mammalia Npy4r 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia NPY4R 36
  • 64 (a)
(Pan troglodytes)
Mammalia NPY4R 36
  • 97 (a)
(Gallus gallus)
Aves PPYR1 35
  • 64.44 (n)
  • 60.28 (a)
PPYR1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia NPY4R 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy4r 35
  • 59.69 (n)
  • 53.3 (a)
(Danio rerio)
Actinopterygii npy8ar 35
  • 58.81 (n)
  • 53.73 (a)
npyryc 35
npy4r 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-12 35
  • 41.78 (n)
  • 31.6 (a)
npr-11 36
  • 26 (a)
npr-12 36
  • 23 (a)
Species with no ortholog for NPY4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY4R Gene

Gene Tree for NPY4R (if available)
Gene Tree for NPY4R (if available)

Paralogs for NPY4R Gene

(9) SIMAP similar genes for NPY4R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY4R: view

Variants for NPY4R Gene

Sequence variations from dbSNP and Humsavar for NPY4R Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_030337 -
VAR_030338 -
rs1573209 -- 46,459,611(-) TGAGG(A/G)AACTT utr-variant-3-prime
rs1573210 -- 46,459,308(-) ATGGG(A/C)AAATT utr-variant-3-prime
rs1573211 -- 46,459,233(-) CCCAA(A/G)GAATT utr-variant-3-prime

Variation tolerance for NPY4R Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NPY4R Gene

Disorders for NPY4R Gene

Relevant External Links for NPY4R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NPY4R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R Gene

Publications for NPY4R Gene

  1. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PMID: 7592911) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1995) 3 4 23 67
  2. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz C.M. … Thompson D.A. (Genomics 1997) 2 3 23
  3. Structure and receptor binding of PYY analogs. (PMID: 11825645) Keire D.A. … Reeve J.R. (Peptides 2002) 3 23
  4. Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. (PMID: 25445712) AragA^n F. … RubA- B. (Biochim. Biophys. Acta 2015) 3
  5. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. (PMID: 24375409) Pedragosa-Badia X. … Beck-Sickinger A.G. (J. Biol. Chem. 2014) 3

Products for NPY4R Gene

Sources for NPY4R Gene