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Aliases for NPY4R Gene

Aliases for NPY4R Gene

  • Neuropeptide Y Receptor Y4 2 3
  • Pancreatic Polypeptide Receptor 1 2 3 4
  • NPY4-R 3 4
  • PPYR1 3 4
  • PP1 3 4
  • Y4 3

External Ids for NPY4R Gene

Previous HGNC Symbols for NPY4R Gene

  • PPYR1

Previous GeneCards Identifiers for NPY4R Gene

  • GC10P047084

Summaries for NPY4R Gene

GeneCards Summary for NPY4R Gene

NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY4R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Gene Wiki entry for NPY4R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY4R Gene

Genomics for NPY4R Gene

Genomic Location for NPY4R Gene

Chromosome:
10
Start:
46,458,551 bp from pter
End:
46,470,647 bp from pter
Size:
12,097 bases
Orientation:
Minus strand

Genomic View for NPY4R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R Gene

No data available for Regulatory Elements for NPY4R Gene

Proteins for NPY4R Gene

  • Protein details for NPY4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50391-NPY4R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 4
    Protein Accession:
    P50391
    Secondary Accessions:
    • Q13456
    • Q5ISU3
    • Q5T2X9
    • Q6FH06

    Protein attributes for NPY4R Gene

    Size:
    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY4R Gene

neXtProt entry for NPY4R Gene

Proteomics data for NPY4R Gene at MOPED

Post-translational modifications for NPY4R Gene

  • Glycosylation at Asn 2, Asn 19, Asn 29, and Asn 187
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY4R Gene

No data available for DME Specific Peptides for NPY4R Gene

Domains & Families for NPY4R Gene

Gene Families for NPY4R Gene

Suggested Antigen Peptide Sequences for NPY4R Gene

Graphical View of Domain Structure for InterPro Entry

P50391

UniProtKB/Swiss-Prot:

NPY4R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R: view

Function for NPY4R Gene

Molecular function for NPY4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

Gene Ontology (GO) - Molecular Function for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 8643460
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with NPY4R: view
genes like me logo Genes that share phenotypes with NPY4R: view

Animal Models for NPY4R Gene

MGI Knock Outs for NPY4R:

Animal Model Products

miRNA for NPY4R Gene

miRTarBase miRNAs that target NPY4R

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY4R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPY4R Gene

Localization for NPY4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8643460
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY4R: view

No data available for Subcellular locations from COMPARTMENTS for NPY4R Gene

Pathways & Interactions for NPY4R Gene

genes like me logo Genes that share pathways with NPY4R: view

Pathways by source for NPY4R Gene

Interacting Proteins for NPY4R Gene

SIGNOR curated interactions for NPY4R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007586 digestion TAS 7592911
GO:0007631 feeding behavior TAS 7592911
genes like me logo Genes that share ontologies with NPY4R: view

Drugs & Compounds for NPY4R Gene

(22) Drugs for NPY4R Gene - From: NovoSeek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbachol Approved Pharma Full agonist, Agonist 3
Dopamine Approved Pharma Full agonist, Agonist 2814
Ethanol Approved Pharma 1708
calyculin a Experimental Pharma 0
okadaic acid Experimental Pharma 0

(13) Additional Compounds for NPY4R Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (porcine)
125580-28-1
BIBP 3226 trifluoroacetate
1068148-47-9
GR 231118
158859-98-4
Neuropeptide Y (human, rat)
90880-35-6
Pancreatic Polypeptide (human)
75976-10-2
genes like me logo Genes that share compounds with NPY4R: view

Transcripts for NPY4R Gene

mRNA/cDNA for NPY4R Gene

(12) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY4R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R Gene

No ASD Table

Relevant External Links for NPY4R Gene

GeneLoc Exon Structure for
NPY4R
ECgene alternative splicing isoforms for
NPY4R

Expression for NPY4R Gene

mRNA expression in normal human tissues for NPY4R Gene

mRNA differential expression in normal tissues according to GTEx for NPY4R Gene

This gene is overexpressed in Colon - Transverse (x14.8) and Colon - Sigmoid (x7.2).

mRNA Expression by UniProt/SwissProt for NPY4R Gene

P50391-NPY4R_HUMAN
Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine
genes like me logo Genes that share expression patterns with NPY4R: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY4R Gene

Orthologs for NPY4R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ppyr1 16
Npy4r 36
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPYR1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY4R 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPY4R 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY4R 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPY4R 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPYR1 35
  • 64.44 (n)
  • 60.28 (a)
PPYR1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY4R 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy4r 35
  • 59.69 (n)
  • 53.3 (a)
zebrafish
(Danio rerio)
Actinopterygii npy8ar 35
  • 58.81 (n)
  • 53.73 (a)
npyryc 35
npy4r 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-12 35
  • 41.78 (n)
  • 31.6 (a)
npr-11 36
  • 26 (a)
ManyToMany
npr-12 36
  • 23 (a)
ManyToMany
Species with no ortholog for NPY4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY4R Gene

ENSEMBL:
Gene Tree for NPY4R (if available)
TreeFam:
Gene Tree for NPY4R (if available)

Paralogs for NPY4R Gene

(9) SIMAP similar genes for NPY4R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY4R: view

Variants for NPY4R Gene

Sequence variations from dbSNP and Humsavar for NPY4R Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1343513 -- 46,472,147(-) CTGCC(G/T)CCCTG upstream-variant-2KB
rs1343514 -- 46,471,714(-) acata(C/T)taagt upstream-variant-2KB
rs1343515 -- 46,470,901(-) gagat(A/G)agcgt upstream-variant-2KB
rs1573209 -- 46,459,611(-) TGAGG(A/G)AACTT utr-variant-3-prime
rs1573210 -- 46,459,308(-) ATGGG(A/C)AAATT utr-variant-3-prime

Variation tolerance for NPY4R Gene

Residual Variation Intolerance Score: 98.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY4R Gene

HapMap Linkage Disequilibrium report
NPY4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPY4R Gene

Disorders for NPY4R Gene

Relevant External Links for NPY4R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY4R
genes like me logo Genes that share disorders with NPY4R: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R Gene

Publications for NPY4R Gene

  1. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz C.M. … Thompson D.A. (Genomics 1997) 2 23 67
  2. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. (PMID: 19953226) Shoblock J.R. … Bonaventure P. (Psychopharmacology (Berl.) 2010) 23 67
  3. Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation. (PMID: 19923221) Ross J.A. … Kirken R.A. (J. Biol. Chem. 2010) 23 67
  4. Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. (PMID: 19094064) Santra M. … Chopp M. (J. Neurochem. 2009) 23 67
  5. G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. (PMID: 19118199) Chung H.J. … Jan L.Y. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67

Products for NPY4R Gene

Sources for NPY4R Gene

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