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Aliases for NPY4R Gene

Aliases for NPY4R Gene

  • Neuropeptide Y Receptor Y4 2 3 5
  • Pancreatic Polypeptide Receptor 1 2 3 4
  • NPY4-R 3 4
  • PPYR1 3 4
  • PP1 3 4
  • Neuropeptide Y Receptor Type 4 3
  • Y4 3

External Ids for NPY4R Gene

Previous HGNC Symbols for NPY4R Gene

  • PPYR1

Previous GeneCards Identifiers for NPY4R Gene

  • GC10P047084

Summaries for NPY4R Gene

GeneCards Summary for NPY4R Gene

NPY4R (Neuropeptide Y Receptor Y4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is LOC105379861.

UniProtKB/Swiss-Prot for NPY4R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Wiki entry for NPY4R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY4R Gene

Genomics for NPY4R Gene

Regulatory Elements for NPY4R Gene

Enhancers for NPY4R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F046417 1.4 FANTOM5 Ensembl ENCODE 7.3 +50.9 50883 3.7 ZNF146 TSC22D4 ZIC2 RAD21 YY1 ZFHX2 ZNF316 POLR2A ZNF366 GATA2 NPY4R SYT15 HNRNPA1P33 PIR43306
GH10F046470 1.2 Ensembl ENCODE 0.8 +0.1 132 0.2 JUND ZFHX2 POLR2A MAX SIN3A MYC EGR2 NPY4R PIR43306
GH10F046468 0.8 FANTOM5 ENCODE 0.8 +2.1 2112 1.2 BCOR CTCF TBL1XR1 CHD4 ZMYM3 SIN3A RAD21 KAT2B SMC3 PRDM10 LINC00842 GPRIN2 NPY4R PIR43306
GH10F046471 0.5 ENCODE 0.8 +0.3 332 0.2 MAX SIN3A ZFHX2 JUND POLR2A FOS MYC EGR2 NPY4R PIR43306
GH10F046473 0.6 ENCODE 0.8 -4.0 -4017 2.0 KLF1 ZNF133 MAFG SIN3A SREBF1 JUND ZNF316 EHMT2 MAFK EMSY AGAP4 NPY4R PIR56474
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NPY4R on UCSC Golden Path with GeneCards custom track

Genomic Location for NPY4R Gene

46,458,551 bp from pter
46,470,647 bp from pter
12,097 bases
Minus strand

Genomic View for NPY4R Gene

Genes around NPY4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY4R Gene

Proteins for NPY4R Gene

  • Protein details for NPY4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 4
    Protein Accession:
    Secondary Accessions:
    • Q13456
    • Q5ISU3
    • Q5T2X9
    • Q6FH06

    Protein attributes for NPY4R Gene

    375 amino acids
    Molecular mass:
    42195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY4R Gene

neXtProt entry for NPY4R Gene

Post-translational modifications for NPY4R Gene

  • Glycosylation at Asn 2, Asn 19, Asn 29, and Asn 187
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY4R Gene

No data available for DME Specific Peptides for NPY4R Gene

Domains & Families for NPY4R Gene

Gene Families for NPY4R Gene

Suggested Antigen Peptide Sequences for NPY4R Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY4R: view

Function for NPY4R Gene

Molecular function for NPY4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Gene Ontology (GO) - Molecular Function for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 8643460
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with NPY4R: view
genes like me logo Genes that share phenotypes with NPY4R: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY4R

miRNA for NPY4R Gene

miRTarBase miRNAs that target NPY4R

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPY4R Gene

Localization for NPY4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY4R Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8643460
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY4R: view

No data available for Subcellular locations from COMPARTMENTS for NPY4R Gene

Pathways & Interactions for NPY4R Gene

genes like me logo Genes that share pathways with NPY4R: view

SIGNOR curated interactions for NPY4R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7592911
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007586 digestion TAS 7592911
genes like me logo Genes that share ontologies with NPY4R: view

Drugs & Compounds for NPY4R Gene

(39) Drugs for NPY4R Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AC162352 Investigational Pharma Target 0
TM30338 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0
[<SUP>125</SUP>I]PP (HUMAN) Pharma 0
[<sup>125</sup>I]PYY (pig) Pharma Full agonist, Agonist 0

(7) Additional Compounds for NPY4R Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)

(5) Tocris Compounds for NPY4R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist 132699-73-1
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist 191868-14-1
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist 246146-55-4
CGP 71683 hydrochloride Highly selective and potent non-peptide NPY Y5 receptor antagonist 192322-50-2
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
genes like me logo Genes that share compounds with NPY4R: view

Transcripts for NPY4R Gene

mRNA/cDNA for NPY4R Gene

(6) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY4R Gene

No ASD Table

Relevant External Links for NPY4R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY4R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPY4R Gene

mRNA differential expression in normal tissues according to GTEx for NPY4R Gene

This gene is overexpressed in Colon - Transverse (x14.8) and Colon - Sigmoid (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of NPY4R Gene:


mRNA Expression by UniProt/SwissProt for NPY4R Gene:

Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.
genes like me logo Genes that share expression patterns with NPY4R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY4R Gene

Orthologs for NPY4R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY4R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY4R 35
  • 97 (a)
(Bos Taurus)
Mammalia PPYR1 35
  • 86 (a)
(Canis familiaris)
Mammalia NPY4R 35
  • 86 (a)
(Mus musculus)
Mammalia Npy4r 35
  • 75 (a)
(Monodelphis domestica)
Mammalia NPY4R 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia NPY4R 35
  • 64 (a)
(Gallus gallus)
Aves PPYR1 34 35
  • 64.44 (n)
(Anolis carolinensis)
Reptilia NPY4R 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy4r 34
  • 59.69 (n)
(Danio rerio)
Actinopterygii npy8ar 34
  • 58.81 (n)
npy4r 35
  • 46 (a)
npyryc 34
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-12 34 35
  • 41.78 (n)
npr-11 35
  • 26 (a)
Species where no ortholog for NPY4R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY4R Gene

Gene Tree for NPY4R (if available)
Gene Tree for NPY4R (if available)

Paralogs for NPY4R Gene

(9) SIMAP similar genes for NPY4R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY4R: view

Variants for NPY4R Gene

Sequence variations from dbSNP and Humsavar for NPY4R Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10587497 -- 46,458,410(-) TTTTT(-/TTT)GTATT intron-variant, downstream-variant-500B
rs11248226 -- 46,458,572(-) tttga(A/G)aagga intron-variant, utr-variant-3-prime
rs112642895 -- 46,459,572(-) ACAAG(A/G)CAGGC intron-variant, utr-variant-3-prime
rs112966378 -- 46,459,431(+) TTTGC(-/A)ATGAT intron-variant, utr-variant-3-prime
rs113864611 -- 46,460,923(-) ACTCA(C/T)TTCCT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPY4R Gene

Variant ID Type Subtype PubMed ID
dgv1106n54 CNV gain 21841781
dgv147n67 CNV gain 20364138
dgv148n67 CNV gain 20364138
dgv218e212 CNV loss 25503493
dgv219e212 CNV gain 25503493
dgv223e212 CNV loss 25503493
dgv224e212 CNV gain 25503493
dgv227e212 CNV loss 25503493
dgv22e55 CNV gain 17911159
dgv409e59 CNV duplication 20981092
dgv440n106 CNV duplication 24896259
dgv734n100 CNV gain 25217958
dgv738n100 CNV loss 25217958
dgv740n100 CNV gain+loss 25217958
dgv743n100 CNV gain 25217958
dgv752n100 CNV loss 25217958
dgv753n100 CNV gain 25217958
dgv763n100 CNV gain 25217958
dgv764n100 CNV loss 25217958
dgv765n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv781n100 CNV loss 25217958
dgv783n100 CNV gain 25217958
dgv800n100 CNV gain 25217958
dgv801n100 CNV gain 25217958
dgv803n100 CNV gain 25217958
dgv806n100 CNV loss 25217958
dgv807n100 CNV gain 25217958
dgv810n100 CNV gain+loss 25217958
dgv811n100 CNV gain 25217958
dgv812n100 CNV loss 25217958
dgv813n100 CNV loss 25217958
dgv814n100 CNV loss 25217958
dgv815n100 CNV gain+loss 25217958
dgv817n100 CNV loss 25217958
dgv818n100 CNV loss 25217958
dgv819n100 CNV gain+loss 25217958
dgv820n100 CNV loss 25217958
dgv821n100 CNV gain 25217958
esv2545436 CNV deletion 19546169
esv2632472 CNV gain 19546169
esv2736152 CNV deletion 23290073
esv2857124 CNV duplication 24192839
esv3333912 CNV duplication 20981092
esv3334625 CNV duplication 20981092
esv3382741 CNV duplication 20981092
esv3577105 CNV gain 25503493
esv3578852 CNV loss 25503493
esv3584617 CNV loss 24956385
esv3891799 CNV gain 25118596
nsv1036434 CNV loss 25217958
nsv1041060 CNV gain+loss 25217958
nsv1043173 CNV gain 25217958
nsv1043881 CNV loss 25217958
nsv1044044 CNV gain+loss 25217958
nsv1046878 CNV gain+loss 25217958
nsv1049965 CNV gain 25217958
nsv1050225 CNV gain+loss 25217958
nsv1052733 CNV loss 25217958
nsv1152446 CNV duplication 26484159
nsv511437 CNV loss 21212237
nsv512161 CNV loss 21212237
nsv550723 CNV gain 21841781
nsv550726 CNV loss 21841781
nsv820817 CNV duplication 20802225
nsv825368 CNV gain 20364138
nsv831853 CNV gain 17160897
nsv947929 CNV duplication 23825009
nsv951576 CNV duplication 24416366

Variation tolerance for NPY4R Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY4R Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY4R Gene

Disorders for NPY4R Gene

Relevant External Links for NPY4R

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NPY4R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY4R Gene

Publications for NPY4R Gene

  1. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PMID: 9417917) Lutz C.M. … Thompson D.A. (Genomics 1997) 2 3 22 64
  2. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PMID: 7592911) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1995) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Structure and receptor binding of PYY analogs. (PMID: 11825645) Keire D.A. … Reeve J.R. (Peptides 2002) 3 22 64
  5. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PMID: 8643460) Yan H. … Karbon W. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 64

Products for NPY4R Gene

Sources for NPY4R Gene

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