Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPY4R Gene

protein-coding   GIFtS: 46
GCID: GC10P047084

Neuropeptide Y Receptor Y4

(Previous name: pancreatic polypeptide receptor 1)
(Previous symbol: PPYR1)
  Search for NPY4R
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuropeptide Y Receptor Y41 2     NPY4-R2 3
PPYR11 2 3 5     Y42
Pancreatic Polypeptide Receptor 11 2 3     Neuropeptide Y Receptor Type 42
PP12 3 5     

External Ids:    HGNC: 93291   Entrez Gene: 55402   Ensembl: ENSG000002041747   OMIM: 6017905   UniProtKB: P503913   

Export aliases for NPY4R gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPY4R Gene: 
NPY4R (neuropeptide Y receptor Y4) is a protein-coding gene. Among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY
(3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

summary for NPY4R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY4R (Pancreatic polypeptide receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPY4R
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY4R promoter sequence
   Search SABiosciences Chromatin IP Primers for NPY4R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPY4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.2

NPY4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY4R gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P047084:  view genomic region     (about GC identifiers)

Start:
47,083,534 bp from pter      End:
47,088,320 bp from pter
Size:
4,787 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 4  
Size: 375 amino acids; 42195 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for NPY4R:
2IK5 (3D)    
Secondary accessions: Q13456 Q5ISU3 Q5T2X9 Q6FH06

Explore the universe of human proteins at neXtProt for NPY4R: NX_P50391

Explore proteomics data for NPY4R at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50391

  • NPY4R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPY4R Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265723.1  NP_005963.4  

    ENSEMBL proteins: 
     ENSP00000379066   ENSP00000363431  
    Reactome Protein details: P50391
    Human Recombinant Protein Products for NPY4R: 
    EMD Millipore Purified and/or Recombinant NPY4R Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NPY4R
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPY4R
    GenScript Custom Purified and Recombinant Proteins Services for NPY4R
    Novus Biologicals NPY4R Proteins
    Novus Biologicals NPY4R Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8643460
    GO:0016021integral to membrane ----

    NPY4R for ontologies           About GeneDecksing



    NPY4R Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NPY4R
    GenScript Custom Superior Antibodies Services for NPY4R
    Novus Biologicals NPY4R Antibodies
    Abcam antibodies for NPY4R
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for NPY4R
    Search LSBio for Antibodies for NPY4R 

    Assay Products for NPY4R: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPY4R
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPY4R
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001933 NPY4_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry P50391

    ProtoNet protein and cluster: P50391

    2 Blocks protein domains:
    IPB000611 Neuropeptide Y receptor signature
    IPB001933 Neuropeptide Y4 receptor signature


    UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NPY4R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY4R_HUMAN, P50391
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY
    (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0001602pancreatic polypeptide receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS8643460
    GO:0042277peptide binding IEA--
         
    NPY4R for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NPY4R:
     Decreased Salmonella enterica   Decreased number of cells in m 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppyr1):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  normal  reproductive system  skeleton 

    NPY4R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NPY4R: Npy4rtm1.1Hhz Npy4rtm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPY4R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPY4R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPY4R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPY4R 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPY4R
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NPY4R
    SwitchGear 3'UTR luciferase reporter plasmidNPY4R 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPY4R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPY4R

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPY4R
    Sirion Biotech Customized adenovirus for overexpression of NPY4R

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of NPY4R
    OriGene clones in human, mouse for NPY4R (see all 7)
    OriGene ORF clones in mouse, rat for NPY4R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NPY4R
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY4R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY4R
    Sirion Biotech Customized lentivirus for stable overexpression of NPY4R 
                         Customized lentivirus expression plasmids for stable overexpression of NPY4R 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPY4R
    Search LifeMap BioReagents cell lines for NPY4R
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY4R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPY4R About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NPY4R
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for NPY4R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for NPY4R (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for NPY4R):
        Neuroactive ligand-receptor interaction


    NPY4R for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPY4R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for NPY4R (P503913 ENSP000003634314) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    PPYP012983, ENSP000002259924I2D: score=1 STRING: ENSP00000225992
    ADCY2ENSP000003429524STRING: ENSP00000342952
    DRD4ENSP000001761834STRING: ENSP00000176183
    GALR1ENSP000002997274STRING: ENSP00000299727
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7592911
    GO:0007586digestion TAS7592911
    GO:0007631feeding behavior TAS7592911
    GO:0008015blood circulation TAS7592911

    NPY4R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPY4R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPY4R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    10/25 Novoseek inferred chemical compound relationships for NPY4R gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibo3304 81.5 2 16807358 (1), 15947033 (1)
    calyculin a 76.8 15 8415615 (2), 8567754 (2), 8750856 (2), 11160648 (2) (see all 7)
    okadaic acid 75 34 10462539 (2), 10504605 (2), 9599018 (2), 8750856 (2) (see all 19)
    tautomycin 69.5 4 7864167 (1), 10485875 (1), 15772123 (1)
    threonine 65.6 21 1668387 (1), 15464122 (1), 10462539 (1), 11062237 (1) (see all 20)
    serine 56.9 21 1668387 (1), 15464122 (1), 17123353 (1), 10462539 (1) (see all 21)
    microcystin-lr 51.9 3 11160648 (1), 18282792 (1)
    tyrosine 40.5 14 10764762 (1), 11062237 (1), 17210286 (1), 10764819 (1) (see all 12)
    phosphatidylinositol 37.4 3 14741844 (1), 16530387 (1), 11739176 (1)
    gf 109203x 28.1 2 11853873 (1), 15750341 (1)

    Search CenterWatch for drugs/clinical trials and news about NPY4R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPY4R gene (2 alternative transcripts): 
    NM_001278794.1  NM_005972.5  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395716 ENST00000374312(uc001jee.3 uc009xna.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPY4R
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NPY4R
    SwitchGear 3'UTR luciferase reporter plasmidNPY4R 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPY4R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPY4R
    Clone
    Products:
         
    OriGene clones in human, mouse for NPY4R (see all 7)
    OriGene ORF clones in mouse, rat for NPY4R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NPY4R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY4R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY4R
    Sirion Biotech Customized lentivirus for stable overexpression of NPY4R 
                         Customized lentivirus expression plasmids for stable overexpression of NPY4R 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY4R
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NPY4R
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPY4R
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPY4R

    3 AceView cDNA sequences:

    CR541950 NM_005972 U42387 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPY4R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NPY4R Expression
    About this image


    See NPY4R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPY4R

    UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
    Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney.
    Detected in colon and small intestine

        SABiosciences Custom PCR Arrays for NPY4R
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY4R
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NPY4R
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPY4R
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPY4R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY4R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NPY4R gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppyr11 , 5 pancreatic polypeptide receptor 11, 5 78.46(n)1
    75.6(a)1
      14 (20.80 cM)5
    190651  NM_008919.41  NP_032945.31 
     341456465 
    chicken
    (Gallus gallus)
    Aves PPYR11 pancreatic polypeptide receptor 1 64.71(n)
    60.89(a)
      428955  NM_001031555.1  NP_001026726.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    NPY4R6
    neuropeptide Y receptor Y4
    52(a)
    51(a)
    possible ortholog
    1 ↔ 1
    GL343484.1(92432-93538)
    GL343297.1(436661-437791)
    zebrafish
    (Danio rerio)
    Actinopterygii npyryc2 neuropeptide Y/peptide YY receptor YC 74.57(n)   30714  NM_131437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR16
    neuropeptide F receptor
    20(a)
    1 → many
    3R(2013122-2021134)
    worm
    (Caenorhabditis elegans)
    Secernentea npr-116
    npr-126
    Protein NPR-12
    24(a)
    20(a)
    many ↔ many
    many ↔ many
    X(1251998-1255629)
    IV(6929088-6931118)


    ENSEMBL Gene Tree for NPY4R (if available)
    TreeFam Gene Tree for NPY4R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPY4R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    9 SIMAP similar genes for NPY4R using alignment to 1 protein entry:     NPY4R_HUMAN:
    PPYR1    NPY1R    NPY6R    PRLHR    GPR83    NPFFR1
    NPFFR2    QRFPR    NPY2R

    NPY4R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 SNPs in NPY4R are shown (see all 227)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012744111,2
    --47081555(+) TTCTC-/AAATGT 1 -- us2k10--------
    rs65995741,2
    C,F,A--47081751(+) CTACCG/ATTACA 1 -- us2k111Minor allele frequency- A:0.37NA WA CSA 137
    rs19813101,2
    C,F,A--47081756(+) ATTACA/CATCAG 1 -- us2k18Minor allele frequency- C:0.45NA WA CSA 20
    rs39162311,2
    C,F,A--47081860(+) GGAGAC/AAAGAG 1 -- us2k14Minor allele frequency- A:0.25NA WA 8
    rs15732131,2
    C,F,A--47081900(+) CAAAGG/CTGCTC 1 -- us2k19Minor allele frequency- C:0.45NA WA CSA 20
    rs39299381,2
    C,F,A--47081938(+) TCTGCT/CTCTGC 1 -- us2k111Minor allele frequency- C:0.32NA WA CSA 22
    rs39299391,2
    C,F--47082009(+) GCAACG/AGAGGA 1 -- us2k114Minor allele frequency- A:0.02NA WA CSA 163
    rs79049751,2
    C,F,H--47082047(+) GGAAGG/CAGCAT 1 -- us2k1 tfbs313Minor allele frequency- C:0.46EA NS NA WA CSA 316
    rs79224331,2
    C,F,A--47082282(+) AGTCTC/ATGCAC 1 -- us2k19Minor allele frequency- A:0.47NA WA CSA 17
    rs79052561,2
    C--47082294(+) ACAAAC/TGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPY4R (47083534 - 47088320 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPY4R: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY4R
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY4R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NPY4R for disorders           About MalaCards
    OMIM gene information: 601790    OMIM disorders: --


    NPY4R for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NPY4R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 32.1 2 7812792 (1), 15895832 (1)


    Export disorders for NPY4R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPY4R gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with NPY4R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PubMed id 7592911)1, 2, 9 Bard J.A.... Weinshank R.L. (1995)
    2. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PubMed id 9417917)1, 3, 9 Lutz C.M....Thompson D.A. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PubMed id 8643460)1, 2 Yan H....Karbon W. (1996)
    5. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. (PubMed id 7493937)1, 2 Lundell I.... Larhammar D. (1995)
    6. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PubMed id 19481128)1, 9 Umeda T....Iwaasa H. (2009)
    7. Clinical potentials of neuropeptide Y family of hormones. (PubMed id 11975932)1, 9 Balasubramaniam A. (2002)
    8. Structure and receptor binding of PYY analogs. (PubMed id 11825645)1, 9 Keire D.A....Reeve J.R. (2002)
    9. Comparison of fragments comprising the first two helic es of the human Y4 and the yeast Ste2p G-protein-coupled receptors. (PubMed id 22947943)1 Shao X....Zerbe O. (2012)
    10. Functional reconstitution of human neuropeptide Y (NP Y) Y(2) and Y(4) receptors in Sf9 insect cells. (PubMed id 21745157)1 Pop N....Buschauer A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5540 HGNC: 9329 AceView: PPYR1 Ensembl:ENSG00000204174 euGenes: HUgn5540
    ECgene: NPY4R Kegg: 5540 H-InvDB: NPY4R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPY4R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPY4R gene:
    Search GeneIP for patents involving NPY4R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Clones for the Expression of NPY4R
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant NPY4R Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Tocris Biochemicals & Compounds for NPY4R (NPY4R)  
     cDNA Clones for NPY4R (NPY4R)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NPY4R  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NPY4R  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPY4R  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPY4R   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPY4R   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPY4R   OriGene Custom Protein Services for NPY4R  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPY4R
     QIAGEN SeqTarget long-range PCR primers for resequencing NPY4R
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPY4R
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPY4R
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPY4R
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPY4R
     GenScript Custom Purified and Recombinant Proteins Services for NPY4R GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NPY4R
     GenScript Custom Assay Services for NPY4R GenScript Custom Superior Antibodies Services for NPY4R
     GenScript Custom overexpressing Cell Line Services for NPY4R CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for NPY4R
     Search Chromatin IP Primers for NPY4R
     Search RT2 qPCR Primer Assays in human, mouse, rat NPY4R
     Search GNC Networks for NPY4R
     SABiosciences Custom PCR Arrays for NPY4R
     Tocris compounds for NPY4R
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPY4R antibodies
     NPY4R proteins
     NPY4R lysates
     Antibodies for NPY4R
     See all of Abcam's Antibodies, Kits and Proteins for NPY4R
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NPY4R
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY4R
     SwitchGear 3'UTR luciferase reporter plasmids for NPY4R
     SwitchGear Promoter luciferase reporter plasmids for NPY4R
     ThermoFisher Antibodies for NPY4R
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY4R
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPY4R
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPY4R
    Customized:
     lentivirus for stable overexpression of NPY4R
     lentivirus expression plasmids for stable overexpression of NPY4R
     adenovirus for overexpression of NPY4R
     Search LSBio for Antibodies for NPY4R
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPY4R gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4