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NPY4R Gene

protein-coding   GIFtS: 48
GCID: GC10P047084

Neuropeptide Y Receptor Y4

(Previous name: pancreatic polypeptide receptor 1)
(Previous symbol: PPYR1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide Y Receptor Y41 2     NPY4-R2 3
PPYR11 2 3 5     Y42
Pancreatic Polypeptide Receptor 11 2 3     Neuropeptide Y Receptor Type 42
PP12 3 5     

External Ids:    HGNC: 93291   Entrez Gene: 55402   Ensembl: ENSG000002041747   OMIM: 6017905   UniProtKB: P503913   

Export aliases for NPY4R gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPY4R Gene:
NPY4R (neuropeptide Y receptor Y4) is a protein-coding gene. GO annotations related to this gene include peptide YY receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY
(3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

summary for NPY4R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY4R (Pancreatic polypeptide receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NPY4R
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY4R promoter sequence
   Search Chromatin IP Primers for NPY4R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11.2

NPY4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY4R gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P047084:  view genomic region     (about GC identifiers)

Start:
47,083,534 bp from pter      End:
47,088,320 bp from pter
Size:
4,787 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 4  
Size: 375 amino acids; 42195 Da
1 PDB 3D structure from and Proteopedia for NPY4R:
2IK5 (3D)    
Secondary accessions: Q13456 Q5ISU3 Q5T2X9 Q6FH06

Explore the universe of human proteins at neXtProt for NPY4R: NX_P50391

Explore proteomics data for NPY4R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn19, Asn29, Asn187
  • Modification sites at PhosphoSitePlus

  • See NPY4R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265723.1  NP_005963.4  

    ENSEMBL proteins: 
     ENSP00000379066   ENSP00000363431  
    Reactome Protein details: P50391

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    4 InterPro protein domains:
     IPR001933 NPY4_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry P50391

    ProtoNet protein and cluster: P50391

    2 Blocks protein domains:
    IPB000611 Neuropeptide Y receptor signature
    IPB001933 Neuropeptide Y4 receptor signature


    UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NPY4R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY4R_HUMAN, P50391
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY
    (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0001602pancreatic polypeptide receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS8643460
    GO:0042277peptide binding IEA--
         
    Find genes that share ontologies with NPY4R           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NPY4R:
     Decreased Salmonella enterica   Decreased number of cells in m 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppyr1):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  normal  reproductive system  skeleton 

    Find genes that share phenotypes with NPY4R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NPY4R: Npy4rtm1.1Hhz Npy4rtm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY4R
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    hsa-mir-335-5p (MIRT017777)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPY4R_HUMAN, P50391: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8643460
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NPY4R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPY4R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with NPY4R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NPY4R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NPY4R
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for NPY4R):
        Neuroactive ligand-receptor interaction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPY4R
    Interactions:

        Search GeneGlobe Interaction Network for NPY4R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY4R (P503913 ENSP000003634314) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    PPYP012983, ENSP000002259924I2D: score=1 STRING: ENSP00000225992
    ADCY2ENSP000003429524STRING: ENSP00000342952
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7592911
    GO:0007586digestion TAS7592911
    GO:0007631feeding behavior TAS7592911
    GO:0008015blood circulation TAS7592911

    Find genes that share ontologies with NPY4R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPY4R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    Selected Novoseek inferred chemical compound relationships for NPY4R gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibo3304 81.5 2 16807358 (1), 15947033 (1)
    calyculin a 76.8 15 8415615 (2), 8567754 (2), 8750856 (2), 11160648 (2) (see all 7)
    okadaic acid 75 34 10462539 (2), 10504605 (2), 9599018 (2), 8750856 (2) (see all 19)
    tautomycin 69.5 4 7864167 (1), 10485875 (1), 15772123 (1)
    threonine 65.6 21 1668387 (1), 15464122 (1), 10462539 (1), 11062237 (1) (see all 20)
    serine 56.9 21 1668387 (1), 15464122 (1), 17123353 (1), 10462539 (1) (see all 21)
    microcystin-lr 51.9 3 11160648 (1), 18282792 (1)
    tyrosine 40.5 14 10764762 (1), 11062237 (1), 17210286 (1), 10764819 (1) (see all 12)
    phosphatidylinositol 37.4 3 14741844 (1), 16530387 (1), 11739176 (1)
    gf 109203x 28.1 2 11853873 (1), 15750341 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPY4R gene (2 alternative transcripts): 
    NM_001278794.1  NM_005972.5  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395716 ENST00000374312(uc001jee.3 uc009xna.3)
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    3 AceView cDNA sequences:

    CR541950 U42387 NM_005972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPY4R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NPY4R Expression
    About this image

    NPY4R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY4R Protein Expression

    UniProtKB/Swiss-Prot: NPY4R_HUMAN, P50391
    Tissue specificity: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney.
    Detected in colon and small intestine

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPY4R gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppyr15 pancreatic polypeptide receptor 1   --   14 (20.80 cM) 34145646 
    chicken
    (Gallus gallus)
    Aves PPYR11 pancreatic polypeptide receptor 1 64.44(n)
    60.28(a)
      428955  NM_001031555.1  NP_001026726.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY4R6
    neuropeptide Y receptor Y4
    51(a)
    1 ↔ 1
    GL343297.1(436661-437791)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npy4r1 neuropeptide Y receptor Y4 59.69(n)
    53.3(a)
      100127810  NM_001113121.1  NP_001106592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npyryc2 neuropeptide Y/peptide YY receptor YC 74.57(n)   30714  NM_131437.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR16
    neuropeptide F receptor
    22(a)
    1 → many
    3R(2013122-2021134)
    worm
    (Caenorhabditis elegans)
    Secernentea npr-121 npr-12 41.78(n)
    31.6(a)
      188742  NM_068670.1  NP_501071.1 


    ENSEMBL Gene Tree for NPY4R (if available)
    TreeFam Gene Tree for NPY4R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPY4R gene
    LOC100996758  GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  TACR12  TACR32  
    NPY1R2  NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    9 SIMAP similar genes for NPY4R using alignment to 1 protein entry:     NPY4R_HUMAN:
    PPYR1    NPY1R    NPY6R    PRLHR    GPR83    NPFFR1
    NPFFR2    QRFPR    NPY2R

    Find genes that share paralogs with NPY4R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPY4R (see all 227)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012744111,2
    --47081555(+) TTCTC-/AAATGT 1 -- us2k10--------
    rs65995741,2
    C,F,A--47081751(+) CTACCG/ATTACA 1 -- us2k111Minor allele frequency- A:0.37NA WA CSA 137
    rs19813101,2
    C,F,A--47081756(+) ATTACA/CATCAG 1 -- us2k18Minor allele frequency- C:0.45NA WA CSA 20
    rs39162311,2
    C,F,A--47081860(+) GGAGAC/AAAGAG 1 -- us2k14Minor allele frequency- A:0.25NA WA 8
    rs15732131,2
    C,F,A--47081900(+) CAAAGG/CTGCTC 1 -- us2k19Minor allele frequency- C:0.45NA WA CSA 20
    rs39299381,2
    C,F,A--47081938(+) TCTGCT/CTCTGC 1 -- us2k111Minor allele frequency- C:0.32NA WA CSA 22
    rs39299391,2
    C,F--47082009(+) GCAACG/AGAGGA 1 -- us2k114Minor allele frequency- A:0.02NA WA CSA 163
    rs79049751,2
    C,F,H--47082047(+) GGAAGG/CAGCAT 1 -- us2k1 tfbs313Minor allele frequency- C:0.46EA NS NA WA CSA 316
    rs79224331,2
    C,F,A--47082282(+) AGTCTC/ATGCAC 1 -- us2k19Minor allele frequency- A:0.47NA WA CSA 17
    rs79052561,2
    C--47082294(+) ACAAAC/TGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPY4R (47083534 - 47088320 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPY4R: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY4R
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY4R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601790    OMIM disorders: --


    Find genes that share disorders with NPY4R           About GenesLikeMe

    1 Novoseek inferred disease relationship for NPY4R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 32.1 2 7812792 (1), 15895832 (1)


    Export disorders for NPY4R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPY4R gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with NPY4R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. (PubMed id 7592911)1, 2, 9 Bard J.A.... Weinshank R.L. (J. Biol. Chem. 1995)
    2. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY. (PubMed id 9417917)1, 3, 9 Lutz C.M....Thompson D.A. (Genomics 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PubMed id 8643460)1, 2 Yan H....Karbon W. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    5. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. (PubMed id 7493937)1, 2 Lundell I.... Larhammar D. (J. Biol. Chem. 1995)
    6. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PubMed id 19481128)1, 9 Umeda T....Iwaasa H. (Peptides 2009)
    7. Clinical potentials of neuropeptide Y family of hormones. (PubMed id 11975932)1, 9 Balasubramaniam A. (Am. J. Surg. 2002)
    8. Structure and receptor binding of PYY analogs. (PubMed id 11825645)1, 9 Keire D.A....Reeve J.R. (Peptides 2002)
    9. Comparison of fragments comprising the first two helices of the human Y4 and the yeast Ste2p G-protein-coupled receptors. (PubMed id 22947943)1 Shao X....Zerbe O. (Biophys. J. 2012)
    10. Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells. (PubMed id 21745157)1 Pop N....Buschauer A. (J. Recept. Signal Transduct. Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5540 HGNC: 9329 AceView: PPYR1 Ensembl:ENSG00000204174 euGenes: HUgn5540
    ECgene: NPY4R Kegg: 5540 H-InvDB: NPY4R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPY4R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NPY4R gene:
    Search GeneIP for patents involving NPY4R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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