Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NPY2R Gene

protein-coding   GIFtS: 66
GCID: GC04P156129

Neuropeptide Y Receptor Y2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Neuropeptide Y Receptor Y21 2
NPY2-R2 3
NPY-Y2 Receptor2 3
Y2 Receptor2 3
Neuropeptide Y Receptor Type 22

External Ids:    HGNC: 79571   Entrez Gene: 48872   Ensembl: ENSG000001851497   OMIM: 1626425   UniProtKB: P491463   

Export aliases for NPY2R gene to outside databases

Previous GC identifers: GC04P157017 GC04P156557 GC04P156707 GC04P156671 GC04P156487 GC04P156349 GC04P151868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NPY2R Gene:
NPY2R (neuropeptide Y receptor Y2) is a protein-coding gene. GO annotations related to this gene include neuropeptide Y receptor activity and receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]
PYY and NPY free acid

summary for NPY2R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY2R (Neuropeptide Y receptor Y2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPY2R gene promoter:
         Nkx3-1   AML1a   Brachyury   Nkx3-1 v1   RelA   Nkx3-1 v2   NRF-2   Nkx3-1 v3   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY2R promoter sequence
   Search Chromatin IP Primers for NPY2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31

NPY2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY2R gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156129:  view genomic region     (about GC identifiers)

Start:
156,129,781 bp from pter      End:
156,138,230 bp from pter
Size:
8,450 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 2  
Size: 381 amino acids; 42731 Da
1 PDB 3D structure from and Proteopedia for NPY2R:
2IK3 (3D)    
Secondary accessions: Q13281 Q13457 Q4W5G7 Q6AZZ6 Q9UE67

Explore the universe of human proteins at neXtProt for NPY2R: NX_P49146

Explore proteomics data for NPY2R at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NPY2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000901.1  
    ENSEMBL proteins: 
     ENSP00000332591   ENSP00000426366  
    Reactome Protein details: P49146

    NPY2R Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant NPY2R Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NPY2R
    GenScript Custom Purified and Recombinant Proteins Services for NPY2R
    Novus Biologicals NPY2R Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPY2R

     
    Search eBioscience for Proteins for NPY2R 

    NPY2R Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NPY2R
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NPY2R
    OriGene Custom Antibody Services for NPY2R
    Novus Biologicals NPY2R Antibodies
    Abcam antibodies for NPY2R
    Cloud-Clone Corp. Antibodies for NPY2R
    ThermoFisher Antibodies for NPY2R
    LSBio Antibodies in human, mouse, rat for NPY2R

    NPY2R Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPY2R
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPY2R
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPY2R
    Cloud-Clone Corp. CLIAs for NPY2R
    Search eBioscience for ELISAs for NPY2R 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: Y2 receptor
    Neuropeptide Y receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt
     IPR001358 NPY2_rcpt

    Graphical View of Domain Structure for InterPro Entry P49146

    ProtoNet protein and cluster: P49146

    2 Blocks protein domains:
    IPB000611 Neuropeptide Y receptor signature
    IPB001358 Neuropeptide Y2 receptor signature


    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NPY2R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY2R_HUMAN, P49146
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]
    PYY and NPY free acid

         Genatlas biochemistry entry for NPY2R:
    neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the
    hippocampus,involved in the presynaptic inhibition of neurotransmitter release

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0004872receptor activity TAS1321422
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity TAS7559383
    GO:0005246calcium channel regulator activity TAS8132547
         
    Find genes that share ontologies with NPY2R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NPY2R:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Npy2r) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  renal/urinary system 

    Find genes that share phenotypes with NPY2R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Npy2rtm1.1Hhz for NPY2R

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY2R
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY2R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPY2R
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPY2R

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NPY2R using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NPY2R:
    hsa-miR-9 hsa-miR-3658 hsa-miR-922 hsa-miR-29a* hsa-miR-16-1* hsa-miR-944 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidNPY2R 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NPY2R
    Predesigned siRNA for gene silencing in human, mouse, rat NPY2R

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPY2R

    Clone
    Products:
         
    OriGene clones in human, mouse for NPY2R (see all 7)
    OriGene ORF clones in mouse, rat for NPY2R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPY2R (NM_000910)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY2R

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPY2R
    Browse ESI BIO Cell Lines and PureStem Progenitors for NPY2R 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NPY2R_HUMAN, P49146: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NPY2R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NPY2R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Neuroeffector Junction)


    Find genes that share SuperPaths with NPY2R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NPY2R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NPY2R
        Peptide ligand-binding receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for NPY2R
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for NPY2R):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY2R: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPY2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY2R (P491461, 3 ENSP000003325914) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    RGS12O149243, ENSP000003393814I2D: score=1 STRING: ENSP00000339381
    PYYP100821, ENSP000003531984EBI-6655721,EBI-6655667 STRING: ENSP00000353198
    SQSTM1Q135013I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0002793positive regulation of peptide secretion IEA--
    GO:0003151outflow tract morphogenesis IMP19593212
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with NPY2R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPY2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    1 DrugBank Compound for NPY2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 19)60-23-1targetother/unknown1314592

    Selected IUPHAR Ligands for NPY2R (Y2 receptor) (see all 27)    About this table
    LigandTypeActionAffinityPubmed IDs
    peptide YY
    AgonistFull agonist9.5 - 9.88632753 7592910
    PYY-(3-36)
    AgonistFull agonist9.2 - 9.78632753 7592910
    [125I]PYY
    AgonistFull agonist9.67559383
    neuropeptide Y
    AgonistFull agonist9.3 - 9.58632753 7592910
    peptide YY
    AgonistFull agonist9.57592910
    PYY-(13-36) (mouse, rat, pig)
    AgonistFull agonist8.8 - 9.48632753 7592910
    NPY-(2-36) (pig)
    AgonistFull agonist8.6 - 9.38632753 7592910
    NPY
    AgonistFull agonist9.1 - 9.38632753 7592910
    NPY-(3-36) (pig)
    AgonistFull agonist9.28632753
    [125I]NPY
    AgonistFull agonist9.27559383

    4 Novoseek inferred chemical compound relationships for NPY2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biie0246 87.7 1 19837904 (1)
    calcium 9.23 4 8914576 (2), 11287092 (1), 9031749 (1)
    alanine 0 1 16319069 (1)
    norepinephrine 0 2 8750699 (1)



    Find genes that share compounds with NPY2R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NPY2R gene: 
    NM_000910.2  

    Unigene Cluster for NPY2R:

    Neuropeptide Y receptor Y2
    Hs.37125  [show with all ESTs]
    Unigene Representative Sequence: NM_000910
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329476(uc003ioq.3) ENST00000506608(uc003ior.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NPY2R using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NPY2R:
    hsa-miR-9 hsa-miR-3658 hsa-miR-922 hsa-miR-29a* hsa-miR-16-1* hsa-miR-944 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidNPY2R 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NPY2R
    Predesigned siRNA for gene silencing in human, mouse, rat NPY2R
    Clone
    Products:
         
    OriGene clones in human, mouse for NPY2R (see all 7)
    OriGene ORF clones in mouse, rat for NPY2R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPY2R (NM_000910)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY2R
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NPY2R
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY2R
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY2R
      QuantiTect SYBR Green Assays in human, mouse, rat NPY2R
      QuantiFast Probe-based Assays in human, mouse, rat NPY2R

    Additional mRNA sequence: 

    BC075052.2 BC075053.2 BC096833.1 U32500.1 U36269.1 U42389.1 U42766.1 

    2 DOTS entries:

    DT.92415971  DT.95254273 

    12 AceView cDNA sequences:

    BQ716967 U36269 U32500 BC075052 CF147774 NM_000910 U42766 BC075053 
    BX283363 U42389 AL138032 BF312604 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NPY2R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NPY2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTATTAGT
    NPY2R Expression
    About this image


    NPY2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Spinal Cord (Nervous System)
    NPY2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37125

    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable
    in caudate nucleus, hypothalamus and substantia nigra

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY2R: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NPY2R
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY2R
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY2R
    QuantiTect SYBR Green Assays in human, mouse, rat NPY2R
    QuantiFast Probe-based Assays in human, mouse, rat NPY2R
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NPY2R gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npy2r1 , 5 neuropeptide Y receptor Y21, 5 87.89(n)1
    94.74(a)1
      3 (36.49 cM)5
    181671  NM_008731.31  NP_032757.21 
     825383835 
    chicken
    (Gallus gallus)
    Aves NPY2R1 neuropeptide Y receptor Y2 74.56(n)
    81.32(a)
      422405  NM_001031128.1  NP_001026299.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY2R6
    neuropeptide Y receptor Y2
    72(a)
    1 ↔ 1
    5(129923776-129924927)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npy2r1 neuropeptide Y receptor Y2 66.58(n)
    72.09(a)
      100498351  XM_004911153.1  XP_004911210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npy2rl1 neuropeptide Y receptor Y2, like 68.5(n)
    70.12(a)
      795311  XM_001332723.3  XP_001332759.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR13 G-protein coupled receptor protein
    signaling pathway more
    35(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59H11AL.13
    npr-61
    npr-61 30(a)
    (best of 2)3
    46.88(n)1
    36.75(a)1
      IV(8559654-8562984)3
    1856231  NM_077324.51  NP_509725.21 


    ENSEMBL Gene Tree for NPY2R (if available)
    TreeFam Gene Tree for NPY2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NPY2R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    16 SIMAP similar genes for NPY2R using alignment to 1 protein entry:     NPY2R_HUMAN:
    DRD3    GPR83    NPFFR2    PRLHR    NPFFR1    QRFPR
    BRS3    GALR1    NPY1R    PROKR1    PROKR2    TACR1
    NPY4R    PPYR1    TACR3    TACR2

    Find genes that share paralogs with NPY2R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NPY2R (see all 235)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868705151,2
    --155920154(+) ATAAAA/GTGTGT 1 -- int10--------
    rs1914083051,2
    --155920264(+) TGGTCA/GTTGTT 1 -- int10--------
    rs68502891,2
    C,F--155920312(+) GGTATA/GTGGTT 1 -- int1 tfbs38Minor allele frequency- G:0.28NA WA EA 368
    rs43331361,2
    C,F,A,H--155920330(+) CACCAG/ATGCAG 1 -- int1 tfbs326Minor allele frequency- A:0.44NA NS EA WA CSA 2492
    rs578695231,2
    C,F--155920425(+) AACAAA/GACAAA 1 -- int13Minor allele frequency- G:0.11WA 122
    rs68512221,2
    C,F--155920456(+) AAGTGG/AAACTG 1 -- int19Minor allele frequency- A:0.36NA CSA WA EA 370
    rs102129381,2
    C,F,H--155920613(+) AAAAAT/CGCCTT 1 -- int110Minor allele frequency- C:0.07NS EA NA CSA WA 1200
    rs1836199991,2
    --155920631(+) CAATAC/TTATTA 1 -- int10--------
    rs1879277291,2
    --155920687(+) GGAAGC/TCTTTA 1 -- int10--------
    rs170326381,2
    C,F,H--155920760(+) AGTAGC/TGGAAT 1 -- int18Minor allele frequency- T:0.01NA NS EA 648

    HapMap Linkage Disequilibrium report for NPY2R (156129781 - 156138230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NPY2R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880309CNV Loss21882294
    nsv881190CNV Loss21882294
    dgv5785n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NPY2R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY2R
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY2R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 162642    OMIM disorders: --


    Find genes that share disorders with NPY2R           About GenesLikeMe

    1 Novoseek inferred disease relationship for NPY2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 20.8 12 17235527 (6), 17019604 (1), 19837904 (1)

    Genetic Association Database (GAD): NPY2R
    Human Genome Epidemiology (HuGE) Navigator: NPY2R (26 documents)

    Export disorders for NPY2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NPY2R gene, integrated from 10 sources (see all 113) (see top 10):
    (articles sorted by number of sources associating them with NPY2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PubMed id 7559383)1, 2, 3 Rose P.M.... Seethala R. (J. Biol. Chem. 1995)
    2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)1, 4, 9 Siddiq A....Froguel P. (Diabetologia 2007)
    3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 4, 9 Campbell C.D....Hirschhorn J.N. (Diabetes 2007)
    4. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PubMed id 17019604)1, 4, 9 Torekov S.S....Pedersen O. (Diabetologia 2006)
    5. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PubMed id 8632753)1, 2, 9 Gehlert D.R.... Gadski R.A. (Mol. Pharmacol. 1996)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. (PubMed id 20811389)1, 4 Sato N....Sugimura H. (J. Hum. Genet. 2010)
    8. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)1, 4 Friedlander Y....Siscovick D.S. (Ann. Hum. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PubMed id 19759915)1, 4 Elbers C.C....Onland-Moret N.C. (PLoS ONE 2009)
    11. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    12. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    13. Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. (PubMed id 19593212)1, 4 Arnett D.K....Broeckel U. (J. Hypertens. 2009)
    14. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    15. [Association between obesity and the polymorphism of neuropeptide Y2 receptor gene in children and adolescents]. (PubMed id 19957593)1, 4 Zhang J....Ma J. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    16. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (PubMed id 18828811)1, 4 Wetherill L....Foroud T. (Alcohol. Clin. Exp. Res. 2008)
    17. Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. (PubMed id 18622237)1, 4 Santoro N....Perrone L. (J. Hypertens. 2008)
    18. No association of sequence variants in the neuropeptide Y2 receptor (NPY2R) gene with early onset obesity in Germans. (PubMed id 17992642)1, 4 Wang H.J....Hinney A. (Horm. Metab. Res. 2007)
    19. Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. (PubMed id 16331299)1, 4 Lavebratt C....Hoffstedt J. (Int J Obes (Lond) 2006)
    20. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (PubMed id 15331560)1, 4 Hung C.C....Farooqi I.S. (Diabetes 2004)
    21. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    22. Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. (PubMed id 8975716)1, 2 Ammar D.A.... Thompson D.A. (Genomics 1996)
    23. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PubMed id 8643460)1, 2 Yan H....Karbon W. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    24. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. (PubMed id 7592910)1, 2 Gerald C....Weinshank R.L. (J. Biol. Chem. 1995)
    25. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. (PubMed id 18700141)1, 9 Parker S.L....Sallee F. (Eur. J. Pharmacol. 2008)
    26. Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain. (PubMed id 9692752)1, 9 Caberlotto L....Hurd Y.L. (Neuroscience 1998)
    27. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. (PubMed id 23149563)1 Wei Z....O'Connor D.T. (J. Hypertens. 2013)
    28. Neuropeptide Y2 receptor (NPY2R) expression in saliva predicts feeding immaturity in the premature neonate. (PubMed id 22629465)1 Maron J.L....Bianchi D.W. (PLoS ONE 2012)
    29. Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of I^-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors. (PubMed id 22487268)1 Kilpatrick L.E....Holliday N.D. (Biochim. Biophys. Acta 2012)
    30. The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus. (PubMed id 23020974)1 Walther C....MAPrl K. (Neuropeptides 2012)
    31. Surface masking shapes the traffic of the neuropeptide Y Y2 receptor. (PubMed id 22732667)1 Parker M.S....Parker S.L. (Peptides 2012)
    32. High expression of NPY receptors in the human testis. (PubMed id 21295110)1 KAPrner M....Reubii J.C. (Mol. Cell. Endocrinol. 2011)
    33. Assessment of a fully active class A G protein-coupled receptor isolated from in vitro folding. (PubMed id 21999704)1 Bosse M....Schmidt P. (Biochemistry 2011)
    34. Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells. (PubMed id 21745157)1 Pop N....Buschauer A. (J. Recept. Signal Transduct. Res. 2011)
    35. Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes. (PubMed id 21696823)1 FAollmar H....Larhammar D. (Neuropeptides 2011)
    36. Neuropeptide Y receptors in carotid plaques of symptomatic and asymptomatic patients: effect of inflammatory cytokines. (PubMed id 21352822)1 Pankajakshan D....Agrawal D.K. (Exp. Mol. Pathol. 2011)
    37. Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. (PubMed id 21818152)1 Hunt S.C....Adams T.D. (Obesity (Silver Spring) 2011)
    38. Variation in the 5'-flanking region of the neuropeptide Y2 receptor gene and metabolic parameters. (PubMed id 20359722)1 Takiguchi E....Kaji H. (Metab. Clin. Exp. 2010)
    39. Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients. (PubMed id 20543711)1 Testa A....Zoccali C. (J. Hypertens. 2010)
    40. Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail. (PubMed id 20959467)1 Walther C....Beck-Sickinger A.G. (J. Biol. Chem. 2010)
    41. A reconstitution protocol for the in vitro folded human G protein-coupled Y2 receptor into lipid environment. (PubMed id 20421142)1 Schmidt P....Huster D. (Biophys. Chem. 2010)
    42. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. (PubMed id 19953226)1 Shoblock J.R....Bonaventure P. (Psychopharmacology (Berl.) 2010)
    43. Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy. (PubMed id 20676138)1 Lu C....Kitlinska J. (Oncogene 2010)
    44. Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions. (PubMed id 20471432)1 Akerberg H....Larhammar D. (Regul. Pept. 2010)
    45. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    46. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PubMed id 19481128)1 Umeda T....Iwaasa H. (Peptides 2009)
    47. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    48. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    49. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    50. The neuropeptide Y (NPY) Y2 receptors are largely dimeric in the kidney, but monomeric in the forebrain. (PubMed id 18569526)1 Parker S.L....Sallee F.R. (J. Recept. Signal Transduct. Res. 2008)
    51. Chromosome 4q31-34 panic disorder risk locus: association of neuropeptide Y Y5 receptor variants. (PubMed id 17948870)1 Domschke K....Deckert J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    52. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    53. Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. (PubMed id 16891622)1 Movafagh S....Zukowska Z. (FASEB J. 2006)
    54. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    55. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (PubMed id 15855352)1 Ma L....Baier L.J. (Diabetes 2005)
    56. High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia. (PubMed id 15623622)1 KAPrner M....Reubi J.C. (Clin. Cancer Res. 2004)
    57. Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues. (PubMed id 12813010)1 Hyland N.P....Cox H.M. (Br. J. Pharmacol. 2003)
    58. Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. (PubMed id 12084524)1 Uddman R....Edvinsson L. (Peptides 2002)
    59. Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. (PubMed id 11906964)1 Cox H.M. and Tough I.R. (Br. J. Pharmacol. 2002)
    60. Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. (PubMed id 12007534)1 Parker E....Stamford A. (Eur. J. Pharmacol. 2002)
    61. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    62. The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. (PubMed id 11408607)1 Goumain M....Laburthe M. (Mol. Pharmacol. 2001)
    63. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. (PubMed id 9651375)1 Snow B.E....Siderovski D.P. (J. Biol. Chem. 1998)
    64. Neuropeptide Y receptor subtypes. (PubMed id 9001438)1 Wan C.P. and Lau B.H. (Life Sci. 1995)
    65. A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line. (PubMed id 8132547)1 Lynch J.W....Takeda K. (J. Biol. Chem. 1994)
    66. Cloned human neuropeptide Y receptor couples to two different second messenger systems. (PubMed id 1321422)1 Herzog H.... Selbie L.A. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    67. Cysteamine selectively enhances neuropeptide Y2 receptor binding activity. (PubMed id 1314592)7 Li W. and Hexum T.D. (Biochem. Biophys. Res. Commun. 1992)
    68. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. (PubMed id 2834384)1 Itoh H.... Kaziro Y. (J. Biol. Chem. 1988)
    69. Neuropeptide Y2 receptors as drug targets for the central regulation of body weight. (PubMed id 16259221)9 FAclActou M. and Levens N.R. (Curr Opin Investig Drugs 2005)
    70. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. (PubMed id 19837904)9 Brothers S.P....Hodder P.S. (Mol. Pharmacol. 2010)
    71. Neuropeptide Y Y2 receptor in health and disease. (PubMed id 17828288)9 Parker S.L. and Balasubramaniam A. (Br. J. Pharmacol. 2008)
    72. [Expression of neuropeptide Y and its receptors in the cardinal ligaments and uterosacral ligaments in patients with pelvic organ prolapse]. (PubMed id 18953866)9 Jiang F....Liu J.P. (Zhonghua Fu Chan Ke Za Zhi 2008)
    73. Patterns of gene expression in pig adipose tissue: insulin-like growth factor system proteins, neuropeptide Y (NPY), NPY receptors, neurotrophic factors and other secreted factors. (PubMed id 18325722)9 Hausman G.J....Dean R.G. (Domest. Anim. Endocrinol. 2008)
    74. Novel cell line selectively expressing neuropeptide Y-Y2 receptors. (PubMed id 14753296)9 HAPfliger M.M....Beck Sickinger A.G. (J. Recept. Signal Transduct. Res. 2003)
    75. Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319. (PubMed id 11287092)9 Grouzmann E....Brunner H. (Peptides 2001)
    76. The dog saphenous vein: a sensitive and selective preparation for the Y2 receptor of neuropeptide Y. (PubMed id 9200555)9 Pheng L.H....Regoli D. (Eur. J. Pharmacol. 1997)
    77. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. (PubMed id 8914576)9 Nakamura M....Hirano D. (Biochim. Biophys. Acta 1996)
    78. Prokaryotic expression, in vitro folding, and molecular pharmacological characterization of the neuropeptide Y receptor type 2. (PubMed id 19725122)9 Schmidt P....Huster D. (Biotechnol. Prog. 2009)
    79. SNP analyses of postprandial responses in (an)orexigenic hormones and feelings of hunger reveal long-term physiological adaptations to facilitate homeostasis. (PubMed id 18957934)9 den Hoed M....Westerterp K.R. (Int J Obes (Lond) 2008)
    80. Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice. (PubMed id 16691011)9 Carvajal C....Quirion R. (J. Mol. Neurosci. 2006)
    81. Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. (PubMed id 16359756)9 Larsson T.A....Larhammar D. (Peptides 2006)
    82. Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. (PubMed id 14617685)9 Bonaventure P....Lovenberg T.W. (J. Pharmacol. Exp. Ther. 2004)
    83. Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding. (PubMed id 11997008)9 Berglund M.M....Larhammar D. (FEBS Lett. 2002)
    84. Cloned neuropeptide Y (NPY) Y1 and pancreatic polypeptide Y4 receptors expressed in Chinese hamster ovary cells show considerable agonist-driven internalization, in contrast to the NPY Y2 receptor. (PubMed id 11179953)9 Parker S.L....Li M.D. (Eur. J. Biochem. 2001)
    85. Molecular characterization of the human neuropeptide Y Y2-receptor. (PubMed id 10346911)9 Ingenhoven N....Beck-Sickinger A.G. (Biochemistry 1999)
    86. Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor. (PubMed id 9802390)9 Sharma P....Larhammar D. (Regul. Pept. 1998)
    87. Modulation of submucosal arteriolar tone by neuropeptide Y Y2 receptors in the guinea-pig small intestine. (PubMed id 9700058)9 Kotecha N. (J. Auton. Nerv. Syst. 1998)
    88. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. (PubMed id 9191097)9 Gustafson E.L....Branchek T.A. (Brain Res. Mol. Brain Res. 1997)
    89. Identification of multiple neuropeptide Y receptor subtypes in the human frontal cortex. (PubMed id 9300264)9 Statnick M.A....Gehlert D.R. (Eur. J. Pharmacol. 1997)
    90. Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. (PubMed id 9031749)9 Connor M....Henderson G. (Br. J. Pharmacol. 1997)
    91. Neuropeptide Y is a vasoconstrictor and adrenergic modulator in the hamster microcirculation by acting on neuropeptide Y1 and Y2 receptors. (PubMed id 8750699)9 Boric M.P....Huidobro-Toro J.P. (Eur. J. Pharmacol. 1995)
    92. Reduction of vasoconstriction mediated by neuropeptide Y Y2 receptors in arterioles of the guinea-pig small intestine. (PubMed id 7670724)9 Neild T.O. and Lewis C.J. (Br. J. Pharmacol. 1995)
    93. A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24-36), with functional specificity for the presynaptic (Y2) receptor. (PubMed id 8088364)9 Potter E.K....Shine J. (Eur. J. Pharmacol. 1994)
    94. Cyclopeptide analogs for characterization of the neuropeptide Y Y2-receptor. (PubMed id 8450492)9 Beck-Sickinger A.G....Jung G. (J. Recept. Res. 1993)
    95. (PubMed id 19060931)9 
    96. Schizophrenia-relevant behaviours in a genetic mouse model for Y2 deficiency. (PubMed id 19879900)9 Karl T....Herzog H. (Behav. Brain Res. 2010)
    97. Peptide YY. (PubMed id 18185065)9 Chandarana K. and Batterham R. (Curr Opin Endocrinol Diabetes Obes 2008)
    98. Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors. (PubMed id 18648328)9 KAPrner M. and Reubi J.C. (J. Neuropathol. Exp. Neurol. 2008)
    99. Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins. (PubMed id 17651824)9 Parker S.L....Balasubramaniam A. (Regul. Pept. 2007)
    100. A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. (PubMed id 16319069)9 Marion S.... Barak L.S. (J. Biol. Chem. 2006)
    101. Localization of novel adiponectin receptor constructs. (PubMed id 17118803)9 Deckert C.M....Beck-Sickinger A.G. (J. Recept. Signal Transduct. Res. 2006)
    102. Angiogenesis and rhodopsin-like receptors: a role for N-terminal acidic residues? (PubMed id 16023616)9 Parker S.L....Sallee F. (Biochem. Biophys. Res. Commun. 2005)
    103. Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization. (PubMed id 15181979)9 Koulu M....Zukowska Z. (Ann. Med. 2004)
    104. Development of a BRET2 screening assay using beta-arrestin 2 mutants. (PubMed id 15191649)9 Vrecl M....Heding A. (J Biomol Screen 2004)
    105. Neuropeptide Y rapidly reduces Period 1 and Period 2 mRNA levels in the hamster suprachiasmatic nucleus. (PubMed id 11704298)9 Fukuhara C....Harrington M.E. (Neurosci. Lett. 2001)
    106. Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family. (PubMed id 10837915)9 Parker R.M.C.... Herzog H. (Brain Res. Mol. Brain Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4887 HGNC: 7957 AceView: NPY2R Ensembl:ENSG00000185149 euGenes: HUgn4887
    ECgene: NPY2R Kegg: 4887 H-InvDB: NPY2R

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NPY2R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NPY2R gene:
    Search GeneIP for patents involving NPY2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant NPY2R Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NPY2R
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for NPY2R (NPY2R)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NPY2R   OriGene RNAi products in human, mouse, rat for NPY2R  
     OriGene qPCR primer pairs and template standards for NPY2R   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPY2R  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPY2R   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPY2R   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPY2R   OriGene Custom Protein Services for NPY2R  

     
     
     Block miRNA regulation of human, mouse, rat NPY2R using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NPY2R
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY2R Predesigned siRNA for gene silencing in human, mouse, rat NPY2R
     QuantiFast Probe-based Assays in human, mouse, rat NPY2R QuantiTect SYBR Green Assays in human, mouse, rat NPY2R
     PCR Arrays including human, mouse, rat NPY2R Search Chromatin IP Primers for NPY2R
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY2R  Search GeneGlobe Interaction Network for NPY2R
     Regulatory tfbs in NPY2R promoter
     GenScript Custom Purified and Recombinant Proteins Services for NPY2R GenScript cDNA clones with any tag delivered in your preferred vector for NPY2R
     GenScript Custom Assay Services for NPY2R GenScript Custom overexpressing Cell Line Services for NPY2R
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for NPY2R
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NPY2R antibodies
     NPY2R proteins
     Antibodies for NPY2R
     See all of Abcam's Antibodies, Kits and Proteins for NPY2R
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NPY2R
     Antibodies for NPY2R
     ELISAs for NPY2R
     CLIAs for NPY2R



     Browse ESI BIO Cell Lines and PureStem Progenitors for NPY2R
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R
     SwitchGear 3'UTR luciferase reporter plasmids for NPY2R
     SwitchGear Promoter luciferase reporter plasmids for NPY2R
     ThermoFisher Antibodies for NPY2R
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY2R
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY2R
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY2R
     LSBio Antibodies in human, mouse, rat for NPY2R
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NPY2R
      Search eBioscience for proteins for NPY2R
      Search eBioscience for elisas for NPY2R
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPY2R gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4