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Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Neuropeptide Y Receptor Type 2 3
  • Y2 Receptor 4

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

Regulatory Elements for NPY2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY2R Gene

155,173,772 bp from pter
155,217,078 bp from pter
43,307 bases
Plus strand

Genomic View for NPY2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Proteomics data for NPY2R Gene at MOPED

Post-translational modifications for NPY2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPY2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPY2R Gene

Domains for NPY2R Gene

Gene Families for NPY2R Gene

  • NPYR :GPCR / Class A : Neuropeptide receptors : Y

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P49146
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Molecular function for NPY2R Gene

GENATLAS Biochemistry: neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release
UniProtKB/Swiss-Prot Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Gene Ontology (GO) - Molecular Function for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0004872 receptor activity TAS 1321422
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 7559383
GO:0005246 calcium channel regulator activity TAS 8132547
genes like me logo Genes that share ontologies with NPY2R: view
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPY2R Gene COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0031513 nonmotile primary cilium IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Pathways for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

Pathways by source for NPY2R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with NPY2R: view

Compounds for NPY2R Gene

(5) Tocris Compounds for NPY2R Gene

Compound Action Cas Number
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
LU AA33810 Potent NPY Y5 receptor antagonist [304008-29-5]
SF 11 NPY Y2 receptor antagonist [443292-81-7]

(1) Drugbank Compounds for NPY2R Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (2-Mercaptoethyl)amine
60-23-1 target other/unknown

(27) IUPHAR Ligand for NPY2R Gene

Ligand Type Action Affinity Pubmed IDs
[125I]PYY Agonist Full agonist 9.6
NPY-(2-36) (pig) Agonist Full agonist 9.3
NPY Agonist Full agonist 9.3
[125I]NPY Agonist Full agonist 9.2
neuropeptide Y Agonist Full agonist 9.1
[Leu31,Pro34]NPY (pig) Agonist Full agonist 9.1
peptide YY Agonist Full agonist 8.9
peptide YY Agonist Full agonist 8.9
NPY-(2-36) Agonist Full agonist 8.9
[Leu31,Pro34]PYY (human) Agonist Full agonist 8.8
C2-NPY (pig) Agonist Full agonist 8.5
BIIE0246 Antagonist Antagonist 8.5
NPY-(20-36) (pig) Agonist Full agonist 8.5
NPY-(16-36) (pig) Agonist Full agonist 8.2
[Ala31,Aib32]NPY (pig) Agonist Full agonist 8.2
[D-Trp32]NPY Agonist Full agonist 8.1
PYY-(3-36) Agonist Full agonist 8
NPY-(3-36) (pig) Agonist Full agonist 8
NPY-(22-36) (pig) Agonist Full agonist 7.4
NPY-(13-36) (pig) Agonist Full agonist 7.3
PYY-(13-36) (mouse, rat, pig) Agonist Full agonist 7.1
JNJ-5207787 Antagonist Antagonist 7.1
NPY-(26-36) (pig) Agonist Full agonist 6.5
[Pro34]PYY (human) Agonist Full agonist 6.3
[Leu31,Pro34]NPY Agonist Full agonist 6.2
neuropeptide Y-(3-36) Agonist Full agonist
[125I]PYY-(3-36) (human) Agonist Full agonist

(4) Novoseek inferred chemical compound relationships for NPY2R Gene

Compound -log(P) Hits PubMed IDs
biie0246 87.7 1
calcium 9.23 4
alanine 0 1
norepinephrine 0 1
genes like me logo Genes that share compounds with NPY2R: view

Transcripts for NPY2R Gene

mRNA/cDNA for NPY2R Gene

(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY2R Gene

Neuropeptide Y receptor Y2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY2R

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY2R Gene

mRNA expression in normal human tissues for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (6.9), Brain - Nucleus accumbens (basal ganglia) (6.1), Brain - Hippocampus (4.5), Brain - Spinal cord (cervical c-1) (4.5), and Brain - Amygdala (4.1).

SOURCE GeneReport for Unigene cluster for NPY2R Gene Hs.37125

mRNA Expression by UniProt/SwissProt for NPY2R Gene

Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra
genes like me logo Genes that share expressions with NPY2R: view

In Situ Assay Products

No data available for Protein expression for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPY2R 35
  • 99.56 (n)
  • 100 (a)
NPY2R 36
  • 100 (a)
(Bos Taurus)
Mammalia NPY2R 35
  • 90.03 (n)
  • 95.01 (a)
NPY2R 36
  • 95 (a)
(Canis familiaris)
Mammalia NPY2R 35
  • 91.16 (n)
  • 94.47 (a)
(Mus musculus)
Mammalia Npy2r 35
  • 87.89 (n)
  • 94.74 (a)
Npy2r 16
Npy2r 36
  • 94 (a)
(Monodelphis domestica)
Mammalia NPY2R 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia NPY2R 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Npy2r 35
  • 86.84 (n)
  • 94.47 (a)
(Gallus gallus)
Aves NPY2R 35
  • 74.56 (n)
  • 81.32 (a)
NPY2R 36
  • 80 (a)
(Anolis carolinensis)
Reptilia NPY2R 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy2r 35
  • 66.58 (n)
  • 72.09 (a)
(Danio rerio)
Actinopterygii npy2r 36
  • 54 (a)
npy2rl 35
  • 68.5 (n)
  • 70.12 (a)
npy2rl 36
  • 62 (a)
npy2rl 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY3 35
  • 49.67 (n)
  • 38.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 36
  • 22 (a)
CG10626 37
  • 32 (a)
NepYr 37
  • 33 (a)
NPFR1 37
  • 35 (a)
(Caenorhabditis elegans)
Secernentea npr-11 36
  • 26 (a)
npr-12 36
  • 20 (a)
npr-6 35
  • 46.88 (n)
  • 36.75 (a)
Y59H11AL.1 37
  • 30 (a)
F41E7.3 37
  • 30 (a)
Species with no ortholog for NPY2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY2R Gene

Gene Tree for NPY2R (if available)
Gene Tree for NPY2R (if available)

Paralogs for NPY2R Gene

Selected SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Sequence variations from dbSNP and Humsavar for NPY2R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1047214 -- 155,214,524(+) ATCAT(C/T)CCGGA reference, synonymous-codon
rs1317359 -- 155,212,069(+) GGAAC(A/G)GTGAG intron-variant
rs1574175 -- 155,212,560(-) CTGGC(A/G)CCTTT intron-variant
rs1574176 -- 155,212,338(-) GATGT(A/T)TTTTT intron-variant
rs1876210 -- 155,177,286(+) atcaa(A/G)caagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
dgv5785n71 CNV Loss 21882294
nsv881190 CNV Loss 21882294
nsv880309 CNV Loss 21882294

Relevant External Links for NPY2R Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY2R Gene

Disorders for NPY2R Gene

(1) Novoseek inferred disease relationships for NPY2R Gene

Disease -log(P) Hits PubMed IDs
obesity 20.8 8

Relevant External Links for NPY2R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPY2R: view

No data available for UniProtKB/Swiss-Prot for NPY2R Gene

Publications for NPY2R Gene

  1. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PMID: 8632753) Gehlert D.R. … Gadski R.A. (Mol. Pharmacol. 1996) 3 4 23
  2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 23 48
  3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23 48
  4. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PMID: 17019604) Torekov S.S. … Pedersen O. (Diabetologia 2006) 3 23 48
  5. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PMID: 7559383) Rose P.M. … Seethala R. (J. Biol. Chem. 1995) 2 3 4

Products for NPY2R Gene

Sources for NPY2R Gene

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