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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPY2R Gene

protein-coding   GIFtS: 66
GCID: GC04P156129

neuropeptide Y receptor Y2
 Explore 17 diseases affiliated with
NPY2R via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPY2R    

Aliases
for NPY2R gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuropeptide Y Receptor Y21 2
NPY2-R2 3
NPY-Y2 Receptor2 3
Y2 Receptor2 3
Neuropeptide Y Receptor Type 22

External Ids:    HGNC: 79571   Entrez Gene: 48872   Ensembl: ENSG000001851497   OMIM: 1626425   UniProtKB: P491463   

Export aliases for NPY2R gene to outside databases

Previous GC identifers: GC04P157017 GC04P156557 GC04P156707 GC04P156671 GC04P156487 GC04P156349 GC04P151868


Summaries
for NPY2R gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY
and NPY free acid

summary for NPY2R:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY2R (Neuropeptide Y receptor Y2)


Genomic Views
for NPY2R gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPY2R gene promoter:
         Nkx3-1   AML1a   Brachyury   Nkx3-1 v1   RelA   Nkx3-1 v2   NRF-2   Nkx3-1 v3   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPY2R promoter sequence
   Search SABiosciences Chromatin IP Primers for NPY2R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPY2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31

NPY2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY2R gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156129:  view genomic region     (about GC identifiers)

Start:
 156,129,781 bp from pter      End:
 156,138,230 bp from pter
Size:
 8,450 bases      Orientation:
 plus strand

Proteins
for NPY2R gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 2  
Size: 381 amino acids; 42731 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for NPY2R:
2IK3 (3D)    
Secondary accessions: Q13281 Q13457 Q4W5G7 Q6AZZ6 Q9UE67

Explore the universe of human proteins at neXtProt for NPY2R: NX_P49146

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49146

    • NPY2R Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000901.1  
    ENSEMBL proteins: 
     ENSP00000332591   ENSP00000426366  
    Reactome Protein details: P49146
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant NPY2R Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NPY2R 
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    Novus Biologicals NPY2R Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPY2R

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7592910


    NPY2R for ontologies           About GeneDecksing



    NPY2R Antibody Products: 
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    Uscn ELISAs and CLIAs for NPY2R

    Protein Domains /
    Families
    for NPY2R gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPY2R for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt
     IPR001358 NPY2_rcpt

    Graphical View of Domain Structure for InterPro Entry P49146

    ProtoNet protein and cluster: P49146

    2 Blocks protein families:
    IPB000611 Neuropeptide Y receptor signature
    IPB001358 Neuropeptide Y2 receptor signature


    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for NPY2R gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY
    and NPY free acid

         Genatlas biochemistry entry for NPY2R:
    neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved
    in the presynaptic inhibition of neurotransmitter release

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NPY2R
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPY2R
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate NPY2R:
    hsa-miR-9 hsa-miR-3658 hsa-miR-922 hsa-miR-29a* hsa-miR-16-1* hsa-miR-944 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: NPY2R 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPY2R (see all 7)
    OriGene shRNA RFP: NPY2R
    OriGene siRNA: NPY2R
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPY2R

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPY2R

    Clone
    Products:             		EMD Millipore Clones for the Expression of NPY2R
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPY2R (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPY2R
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NPY2R (NM_000910)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY2R 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NPY2R
    Search LifeMap BioReagents cell lines for NPY2R

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0004872receptor activity TAS1321422
    GO:0004983neuropeptide Y receptor activity TAS7559383
    GO:0005246calcium channel regulator activity TAS8132547


    NPY2R for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NPY2R:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Npy2rtm1.1Hhz for NPY2R
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Npy2r) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  reproductive system 

    NPY2R for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPY2R gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46
    4Sympathetic Nerve Pathway (Neuroeffector Junction)
    		Sympathetic Nerve Pathway (Neuroeffector Junction)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NPY2R
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for NPY2R 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for NPY2R (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events

    1 PharmGKB Pathway for NPY2R
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1         Kegg Pathway  (Kegg details for NPY2R):
        Neuroactive ligand-receptor interaction


    NPY2R for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPY2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    122/145 Interacting proteins for NPY2R (P491463 ENSP000003325914) via UniProtKB, MINT, STRING, and/or I2D (see all 145) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    RGS12O149243, ENSP000003393814I2D: score=1 STRING: ENSP00000339381
    SQSTM1Q135013I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    C3AR1ENSP000003020794STRING: ENSP00000302079
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR7ENSP000002466574STRING: ENSP00000246657
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR5ENSP000002921744STRING: ENSP00000292174
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    DRD4ENSP000001761834STRING: ENSP00000176183
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR3ENSP000002490414STRING: ENSP00000249041
    HRH3ENSP000003425604STRING: ENSP00000342560
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1FENSP000003229244STRING: ENSP00000322924
    KNG1ENSP000002650234STRING: ENSP00000265023
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRM1ENSP000003946244STRING: ENSP00000394624
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PENKENSP000003242484STRING: ENSP00000324248
    PNOCENSP000003019084STRING: ENSP00000301908
    POMCENSP000002647084STRING: ENSP00000264708
    PPYENSP000002259924STRING: ENSP00000225992
    PPYR1ENSP000003634314STRING: ENSP00000363431
    RGS4ENSP000003971814STRING: ENSP00000397181
    RXFP4ENSP000003573014STRING: ENSP00000357301
    SSTENSP000002876414STRING: ENSP00000287641
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR4ENSP000002550084STRING: ENSP00000255008
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA3ENSP000003587304STRING: ENSP00000358730
    AGTR2ENSP000003609734STRING: ENSP00000360973
    ANXA1ENSP000002574974STRING: ENSP00000257497
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3ENSP000002459074STRING: ENSP00000245907
    C5ENSP000002236424STRING: ENSP00000223642
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CASRENSP000002961544STRING: ENSP00000296154
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR8ENSP000003264324STRING: ENSP00000326432
    CHRM4ENSP000004093784STRING: ENSP00000409378
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR6ENSP000003044144STRING: ENSP00000304414
    CXCR7ENSP000002729284STRING: ENSP00000272928
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    GALR2ENSP000003296844STRING: ENSP00000329684
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPERENSP000002974694STRING: ENSP00000297469
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1AENSP000003028114STRING: ENSP00000302811
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    OPRL1ENSP000003367644STRING: ENSP00000336764
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY14ENSP000003083614STRING: ENSP00000308361
    PDYNENSP000002173054STRING: ENSP00000217305
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003151outflow tract morphogenesis IMP19593212
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS7559383
    GO:0007626locomotory behavior TAS9692752


    NPY2R for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPY2R gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPY2R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPY2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Neuropeptide Y 13-36 (porcine)NPY Y2 receptor agonist[113662-54-7]
    BIIE 0246 Potent, selective non-peptide NPY Y2 antagonist [246146-55-4]
    Peptide YY (3-36)Selective NPY Y2 receptor agonist[126339-09-1]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    Neuropeptide Y (porcine)Influences feeding and sexual behavior--

    1 DrugBank Compound for NPY2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 20)60-23-1targetother/unknown1314592

    4 Novoseek chemical compound relationships for NPY2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biie0246 87.7 1 19837904 (1)
    calcium 9.23 4 8914576 (2), 11287092 (1), 9031749 (1)
    alanine 0 1 16319069 (1)
    norepinephrine 0 2 8750699 (1)

    Search CenterWatch for drugs/clinical trials and news about NPY2R 

    Transcripts
    for NPY2R gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPY2R gene: 
    NM_000910.2  

    Unigene Cluster for NPY2R:

    Neuropeptide Y receptor Y2
    Hs.37125  [show with all ESTs]
    Unigene Representative Sequence: NM_000910
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329476(uc003ioq.3) ENST00000506608(uc003ior.3)

    miRNA
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    Additional cDNA sequence: 

    BC075052.2 BC075053.2 BC096833.1 U32500.1 U36269.1 U42389.1 U42766.1 

    2 DOTS entries:

    DT.92415971  DT.95254273 

    12 AceView cDNA sequences:

    BQ716967 U36269 BC075053 U32500 NM_000910 U42766 CF147774 BC075052 
    BX283363 BF312604 AL138032 U42389 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NPY2R

    Expression
    for NPY2R gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPY2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTATTAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPY2R expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Beating cell clusters (Spontaneous differen...)

    See NPY2R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPY2R

    SOURCE GeneReport for Unigene cluster: Hs.37125

    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in
    caudate nucleus, hypothalamus and substantia nigra

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    Primer
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    Orthologs
    for NPY2R gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NPY2R gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NPY2R1 neuropeptide Y receptor Y2 74.56(n)
    81.32(a)    		   422405  NM_001031128.1  NP_001026299.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NPY2R6
    --
    		 --
    		 72(a)
    20(a)
    		 1 ↔ 1
    possible ortholog
    		 5(129923776-129924927)
    GL344580.1(6867-15398)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7953111 neuropeptide Y receptor type 2-like 68.5(n)
    70.12(a)    		   795311  XM_001332723.2  XP_001332759.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta NPFR11 , 3 G-protein coupled receptor protein signaling
    pathway neuropeptide Y receptor less3
    neuropeptide F receptor1    		 35(a)
    (best of 3)3
    49.35(n)1
    37.72(a)1    		   407541  NM_079521.31  NP_524245.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y59H11AL.13   -- 30(a)
    (best of 2)    		   IV(8559654-8562984)   --


    ENSEMBL Gene Tree for NPY2R (if available)
    TreeFam Gene Tree for NPY2R (if available) 

    Paralogs
    for NPY2R gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPY2R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  PPYR12  NPY5R2  TACR12  TACR32  
    NPY1R2  QRFPR2  NPFFR12  HCRTR12  TACR22  
    16 SIMAP similar genes for NPY2R using alignment to 1 protein entry:     NPY2R_HUMAN:
    DRD3    GPR83    NPFFR2    PRLHR    NPFFR1    QRFPR
    BRS3    GALR1    NPY1R    PROKR1    PROKR2    TACR1
    PPYR1    TACR3    TACR2    HCRTR2

    NPY2R for paralogs           About GeneDecksing



    Genomic Variants
    for NPY2R gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): NPY2R
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPY2R
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    Disorders / Diseases
    for NPY2R gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPY2R for disorders           About GeneDecksing

    OMIM gene information: 162642    OMIM disorders: --

    17 diseases for NPY2R:    About MalaCards
    autism spectrum disorder    corpus callosum    cocaine dependence    anorexia nervosa
    alcohol dependence    panic disorder    diabetic retinopathy    obesity
    pertussis    alcoholism    glioblastoma    hypertension
    neuroblastoma    retinitis    schizophrenia    pancreatitis
    neuronitis

    1 Novoseek disease relationship for NPY2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 20.8 12 17235527 (6), 17019604 (1), 19837904 (1)

    Genetic Association Database (GAD): NPY2R
    Human Genome Epidemiology (HuGE) Navigator: NPY2R (26 documents)

    Export disorders for NPY2R gene to outside databases

    Publications
    for NPY2R gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPY2R gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with NPY2R)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PubMed id 7559383)1, 2, 3 Rose P.M.... Seethala R. (1995)
    2. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PubMed id 8632753)1, 2, 9 Gehlert D.R.... Gadski R.A. (1996)
    3. Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. (PubMed id 16331299)1, 4 Lavebratt C....Hoffstedt J. (2006)
    4. Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (PubMed id 15331560)1, 4 Hung C.C....Farooqi I.S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. (PubMed id 8975716)1, 2 Ammar D.A.... Thompson D.A. (1996)
    7. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. (PubMed id 8643460)1, 2 Yan H....Karbon W. (1996)
    8. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. (PubMed id 7592910)1, 2 Gerald C....Weinshank R.L. (1995)
    9. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)1, 9 Siddiq A....Froguel P. (2007)
    10. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 9 Campbell C.D....Hirschhorn J.N. (2007)

    External Searches for NPY2R gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPY2R gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4887 HGNC: 7957 AceView: NPY2R Ensembl:ENSG00000185149 euGenes: HUgn4887
    ECgene: NPY2R Kegg: 4887 H-InvDB: NPY2R

    Other Databases showing NPY2R gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPY2R gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPY2R Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPY2R gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPY2R gene:
    Search GeneIP for patents involving NPY2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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