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Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Y2 Receptor 4

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Diseases associated with NPY2R include obesity. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and calcium channel regulator activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

Regulatory Elements for NPY2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY2R Gene

Chromosome:
4
Start:
155,173,754 bp from pter
End:
155,217,096 bp from pter
Size:
43,343 bases
Orientation:
Plus strand

Genomic View for NPY2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49146-NPY2R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    P49146
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    Size:
    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Proteomics data for NPY2R Gene at MOPED

Post-translational modifications for NPY2R Gene

  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPY2R Gene

Domains & Families for NPY2R Gene

Gene Families for NPY2R Gene

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49146

UniProtKB/Swiss-Prot:

NPY2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Molecular function for NPY2R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Gene Ontology (GO) - Molecular Function for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0004872 receptor activity TAS 1321422
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 7559383
GO:0005246 calcium channel regulator activity TAS 8132547
genes like me logo Genes that share ontologies with NPY2R: view
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

miRNA for NPY2R Gene

miRTarBase miRNAs that target NPY2R

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY2R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPY2R Gene COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY2R: view

Pathways & Interactions for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

Pathways by source for NPY2R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for NPY2R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with NPY2R: view

Drugs & Compounds for NPY2R Gene

(35) Drugs for NPY2R Gene - From: IUPHAR, DGIdb, NovoSeek, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma Target, other/unknown 22
Norepinephrine Approved Pharma 206
AC162352 Investigational Pharma Target 0
TM30338 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0

(6) Additional Compounds for NPY2R Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]NPY
Full agonist, Agonist
[Leu31,Pro34]-Neuropeptide Y (porcine)
125580-28-1
BIBP 3226 trifluoroacetate
1068148-47-9
GR 231118
158859-98-4
Neuropeptide Y (human, rat)
90880-35-6
genes like me logo Genes that share compounds with NPY2R: view

Transcripts for NPY2R Gene

mRNA/cDNA for NPY2R Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY2R Gene

Neuropeptide Y receptor Y2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY2R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for
NPY2R
ECgene alternative splicing isoforms for
NPY2R

Expression for NPY2R Gene

mRNA expression in normal human tissues for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Hippocampus (x4.5), Brain - Spinal cord (cervical c-1) (x4.5), and Brain - Amygdala (x4.1).

SOURCE GeneReport for Unigene cluster for NPY2R Gene Hs.37125

mRNA Expression by UniProt/SwissProt for NPY2R Gene

P49146-NPY2R_HUMAN
Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra
genes like me logo Genes that share expression patterns with NPY2R: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPY2R 35
  • 90.03 (n)
  • 95.01 (a)
NPY2R 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY2R 35
  • 91.16 (n)
  • 94.47 (a)
mouse
(Mus musculus)
Mammalia Npy2r 35
  • 87.89 (n)
  • 94.74 (a)
Npy2r 16
Npy2r 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPY2R 35
  • 99.56 (n)
  • 100 (a)
NPY2R 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npy2r 35
  • 86.84 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia NPY2R 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY2R 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPY2R 35
  • 74.56 (n)
  • 81.32 (a)
NPY2R 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY2R 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy2r 35
  • 66.58 (n)
  • 72.09 (a)
zebrafish
(Danio rerio)
Actinopterygii npy2rl 35
  • 68.5 (n)
  • 70.12 (a)
npy2r 36
  • 54 (a)
OneToMany
npy2rl 36
  • 62 (a)
OneToMany
npy2rl 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 33 (a)
NPFR1 37
  • 35 (a)
NPFR1 36
  • 22 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY3 35
  • 49.67 (n)
  • 38.49 (a)
worm
(Caenorhabditis elegans)
Secernentea F41E7.3 37
  • 30 (a)
Y59H11AL.1 37
  • 30 (a)
npr-6 35
  • 46.88 (n)
  • 36.75 (a)
npr-11 36
  • 26 (a)
ManyToMany
npr-12 36
  • 20 (a)
ManyToMany
Species with no ortholog for NPY2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY2R Gene

ENSEMBL:
Gene Tree for NPY2R (if available)
TreeFam:
Gene Tree for NPY2R (if available)

Paralogs for NPY2R Gene

(16) SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
dgv5785n71 CNV Loss 21882294
nsv881190 CNV Loss 21882294
nsv880309 CNV Loss 21882294

Variation tolerance for NPY2R Gene

Residual Variation Intolerance Score: 29.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY2R Gene

HapMap Linkage Disequilibrium report
NPY2R
Human Gene Mutation Database (HGMD)
NPY2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NPY2R Gene

Disorders for NPY2R Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPY2R Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association
Search NPY2R in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPY2R

Genetic Association Database (GAD)
NPY2R
Human Genome Epidemiology (HuGE) Navigator
NPY2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY2R
genes like me logo Genes that share disorders with NPY2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY2R Gene

Publications for NPY2R Gene

  1. Schizophrenia-relevant behaviours in a genetic mouse model for Y2 deficiency. (PMID: 19879900) Karl T. … Herzog H. (Behav. Brain Res. 2010) 23 67
  2. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. (PMID: 19837904) Brothers S.P. … Hodder P.S. (Mol. Pharmacol. 2010) 23 67
  3. Prokaryotic expression, in vitro folding, and molecular pharmacological characterization of the neuropeptide Y receptor type 2. (PMID: 19725122) Schmidt P. … Huster D. (Biotechnol. Prog. 2009) 23 67
  4. Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors. (PMID: 18648328) KAPrner M. … Reubi J.C. (J. Neuropathol. Exp. Neurol. 2008) 23 67
  5. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. (PMID: 18700141) Parker S.L. … Sallee F. (Eur. J. Pharmacol. 2008) 23 67

Products for NPY2R Gene

Sources for NPY2R Gene

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