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Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Neuropeptide Y Receptor Type 2 3
  • Y2 Receptor 4

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

Regulatory Elements for NPY2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY2R Gene

155,173,772 bp from pter
155,217,078 bp from pter
43,307 bases
Plus strand

Genomic View for NPY2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Proteomics data for NPY2R Gene at MOPED

Post-translational modifications for NPY2R Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPY2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPY2R Gene

Domains for NPY2R Gene

Gene Families for NPY2R Gene

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Molecular function for NPY2R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid

Gene Ontology (GO) - Molecular Function for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0004872 receptor activity TAS 1321422
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 7559383
GO:0005246 calcium channel regulator activity TAS 8132547
genes like me logo Genes that share ontologies with NPY2R: view
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY2R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPY2R Gene COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0031513 nonmotile primary cilium IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Pathways for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

Pathways by source for NPY2R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with NPY2R: view

Drugs for NPY2R Gene

(3) Drugbank Compounds for NPY2R Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 2-Amino-1-ethanethiol
60-23-1 6058 Target other/unknown approved, investigational
  • PYY 3-36
Target investigational
  • Obinepitide
Target investigational

(5) Tocris Compounds for NPY2R Gene

Compound Action Cas Number
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
LU AA33810 Potent NPY Y5 receptor antagonist [304008-29-5]
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]
SF 11 NPY Y2 receptor antagonist [443292-81-7]

(1) ApexBio Compounds for NPY2R Gene

Compound Action Cas Number
Peptide YY(3-36), PYY, human Y2R agonist [123583-37-9]

(26) IUPHAR Ligand for NPY2R Gene

Ligand Type Action Affinity Pubmed IDs
[125I]PYY Agonist Full agonist 9.6
NPY-(2-36) (pig) Agonist Full agonist 9.3
NPY Agonist Full agonist 9.3
[125I]NPY Agonist Full agonist 9.2
[Leu31,Pro34]NPY (pig) Agonist Full agonist 9.1
neuropeptide Y Agonist Full agonist 9.1
NPY-(2-36) Agonist Full agonist 8.9
peptide YY Agonist Full agonist 8.9
[Leu31,Pro34]PYY (human) Agonist Full agonist 8.8
C2-NPY (pig) Agonist Full agonist 8.5
BIIE0246 Antagonist Antagonist 8.5
NPY-(20-36) (pig) Agonist Full agonist 8.5
[Ala31,Aib32]NPY (pig) Agonist Full agonist 8.2
NPY-(16-36) (pig) Agonist Full agonist 8.2
[D-Trp32]NPY Agonist Full agonist 8.1
NPY-(3-36) (pig) Agonist Full agonist 8
PYY-(3-36) Agonist Full agonist 8
NPY-(22-36) (pig) Agonist Full agonist 7.4
NPY-(13-36) (pig) Agonist Full agonist 7.3
PYY-(13-36) (mouse, rat, pig) Agonist Full agonist 7.1
JNJ-5207787 Antagonist Antagonist 7.1
NPY-(26-36) (pig) Agonist Full agonist 6.5
[Pro34]PYY (human) Agonist Full agonist 6.3
[Leu31,Pro34]NPY Agonist Full agonist 6.2
neuropeptide Y-(3-36) Agonist Full agonist
[125I]PYY-(3-36) (human) Agonist Full agonist

(4) Novoseek inferred chemical compound relationships for NPY2R Gene

Compound -log(P) Hits PubMed IDs
biie0246 87.7 1
calcium 9.23 4
alanine 0 1
norepinephrine 0 1
genes like me logo Genes that share compounds with NPY2R: view

Transcripts for NPY2R Gene

mRNA/cDNA for NPY2R Gene

(12) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY2R Gene

Neuropeptide Y receptor Y2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY2R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY2R Gene

mRNA expression in normal human tissues for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (6.9), Brain - Nucleus accumbens (basal ganglia) (6.1), Brain - Hippocampus (4.5), Brain - Spinal cord (cervical c-1) (4.5), and Brain - Amygdala (4.1).

SOURCE GeneReport for Unigene cluster for NPY2R Gene Hs.37125

mRNA Expression by UniProt/SwissProt for NPY2R Gene

Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra
genes like me logo Genes that share expressions with NPY2R: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPY2R 35
  • 90.03 (n)
  • 95.01 (a)
NPY2R 36
  • 95 (a)
(Canis familiaris)
Mammalia NPY2R 35
  • 91.16 (n)
  • 94.47 (a)
(Mus musculus)
Mammalia Npy2r 35
  • 87.89 (n)
  • 94.74 (a)
Npy2r 16
Npy2r 36
  • 94 (a)
(Pan troglodytes)
Mammalia NPY2R 35
  • 99.56 (n)
  • 100 (a)
NPY2R 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Npy2r 35
  • 86.84 (n)
  • 94.47 (a)
(Monodelphis domestica)
Mammalia NPY2R 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia NPY2R 36
  • 86 (a)
(Gallus gallus)
Aves NPY2R 35
  • 74.56 (n)
  • 81.32 (a)
NPY2R 36
  • 80 (a)
(Anolis carolinensis)
Reptilia NPY2R 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy2r 35
  • 66.58 (n)
  • 72.09 (a)
(Danio rerio)
Actinopterygii npy2rl 35
  • 68.5 (n)
  • 70.12 (a)
npy2r 36
  • 54 (a)
npy2rl 36
  • 62 (a)
npy2rl 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 33 (a)
NPFR1 37
  • 35 (a)
NPFR1 36
  • 22 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNPY3 35
  • 49.67 (n)
  • 38.49 (a)
(Caenorhabditis elegans)
Secernentea F41E7.3 37
  • 30 (a)
Y59H11AL.1 37
  • 30 (a)
npr-6 35
  • 46.88 (n)
  • 36.75 (a)
npr-11 36
  • 26 (a)
npr-12 36
  • 20 (a)
Species with no ortholog for NPY2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY2R Gene

Gene Tree for NPY2R (if available)
Gene Tree for NPY2R (if available)

Paralogs for NPY2R Gene

(16) SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Sequence variations from dbSNP and Humsavar for NPY2R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs77408021 -- 155,200,219(-) TAAAT(A/G)TCTTC intron-variant
rs77436952 -- 155,191,166(+) TGAAG(A/G)AGAGA intron-variant
rs77446764 -- 155,172,436(+) TTTCT(A/T)TCTTT upstream-variant-2KB
rs77696896 -- 155,189,289(+) ATAAT(A/C)TTTTA intron-variant
rs77313430 -- 155,188,799(+) GATGG(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
dgv5785n71 CNV Loss 21882294
nsv881190 CNV Loss 21882294
nsv880309 CNV Loss 21882294

Relevant External Links for NPY2R Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY2R Gene

Disorders for NPY2R Gene

(1) Novoseek inferred disease relationships for NPY2R Gene

Disease -log(P) Hits PubMed IDs
obesity 20.8 8

Relevant External Links for NPY2R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPY2R: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NPY2R Gene

Publications for NPY2R Gene

  1. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 23 48
  2. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23 48
  3. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PMID: 7559383) Rose P.M. … Seethala R. (J. Biol. Chem. 1995) 2 3 4
  4. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PMID: 17019604) Torekov S.S. … Pedersen O. (Diabetologia 2006) 3 23 48
  5. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PMID: 8632753) Gehlert D.R. … Gadski R.A. (Mol. Pharmacol. 1996) 3 4 23

Products for NPY2R Gene

Sources for NPY2R Gene

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