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NPY2R Gene

protein-coding   GIFtS: 66
GCID: GC04P156129

Neuropeptide Y Receptor Y2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide Y Receptor Y21 2
NPY2-R2 3
NPY-Y2 Receptor2 3
Y2 Receptor2 3
Neuropeptide Y Receptor Type 22

External Ids:    HGNC: 79571   Entrez Gene: 48872   Ensembl: ENSG000001851497   OMIM: 1626425   UniProtKB: P491463   

Export aliases for NPY2R gene to outside databases

Previous GC identifers: GC04P157017 GC04P156557 GC04P156707 GC04P156671 GC04P156487 GC04P156349 GC04P151868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPY2R Gene:
NPY2R (neuropeptide Y receptor Y2) is a protein-coding gene. Diseases associated with NPY2R include cocaine dependence, and pertussis. GO annotations related to this gene include neuropeptide Y receptor activity and receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]
PYY and NPY free acid

summary for NPY2R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY2R (Neuropeptide Y receptor Y2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPY2R gene promoter:
         Nkx3-1   AML1a   Brachyury   Nkx3-1 v1   RelA   Nkx3-1 v2   NRF-2   Nkx3-1 v3   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY2R promoter sequence
   Search Chromatin IP Primers for NPY2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31

NPY2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY2R gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156129:  view genomic region     (about GC identifiers)

Start:
156,129,781 bp from pter      End:
156,138,230 bp from pter
Size:
8,450 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 2  
Size: 381 amino acids; 42731 Da
1 PDB 3D structure from and Proteopedia for NPY2R:
2IK3 (3D)    
Secondary accessions: Q13281 Q13457 Q4W5G7 Q6AZZ6 Q9UE67

Explore the universe of human proteins at neXtProt for NPY2R: NX_P49146

Explore proteomics data for NPY2R at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NPY2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000901.1  
    ENSEMBL proteins: 
     ENSP00000332591   ENSP00000426366  
    Reactome Protein details: P49146

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: Y2 receptor
    Neuropeptide Y receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt
     IPR001358 NPY2_rcpt

    Graphical View of Domain Structure for InterPro Entry P49146

    ProtoNet protein and cluster: P49146

    2 Blocks protein domains:
    IPB000611 Neuropeptide Y receptor signature
    IPB001358 Neuropeptide Y2 receptor signature


    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NPY2R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY2R_HUMAN, P49146
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]
    PYY and NPY free acid

         Genatlas biochemistry entry for NPY2R:
    neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the
    hippocampus,involved in the presynaptic inhibition of neurotransmitter release

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0004872receptor activity TAS1321422
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity TAS7559383
    GO:0005246calcium channel regulator activity TAS8132547
         
    NPY2R for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPY2R:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Npy2r) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  renal/urinary system 

    NPY2R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Npy2rtm1.1Hhz for NPY2R

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY2R
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    7 qRT-PCR Assays for microRNAs that regulate NPY2R:
    hsa-miR-9 hsa-miR-3658 hsa-miR-922 hsa-miR-29a* hsa-miR-16-1* hsa-miR-944 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidNPY2R 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NPY2R (NM_000910)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPY2R_HUMAN, P49146: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    NPY2R for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPY2R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NPY2R
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NPY2R
        Peptide ligand-binding receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for NPY2R
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for NPY2R):
        Neuroactive ligand-receptor interaction


    NPY2R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY2R: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPY2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY2R (P491461, 3 ENSP000003325914) via UniProtKB, MINT, STRING, and/or I2D (see all 145) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    RGS12O149243, ENSP000003393814I2D: score=1 STRING: ENSP00000339381
    PYYP100821, ENSP000003531984EBI-6655721,EBI-6655667 STRING: ENSP00000353198
    SQSTM1Q135013I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR7ENSP000002466574STRING: ENSP00000246657
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CHRM4ENSP000004093784STRING: ENSP00000409378
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR5ENSP000002921744STRING: ENSP00000292174
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    DRD4ENSP000001761834STRING: ENSP00000176183
    FPR3ENSP000003418214STRING: ENSP00000341821
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    HRH3ENSP000003425604STRING: ENSP00000342560
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1FENSP000003229244STRING: ENSP00000322924
    KNG1ENSP000002650234STRING: ENSP00000265023
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1AENSP000003028114STRING: ENSP00000302811
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPWENSP000003300704STRING: ENSP00000330070
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRM1ENSP000003946244STRING: ENSP00000394624
    OXER1ENSP000003679304STRING: ENSP00000367930
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PENKENSP000003242484STRING: ENSP00000324248
    PNOCENSP000003019084STRING: ENSP00000301908
    POMCENSP000002647084STRING: ENSP00000264708
    PPYENSP000002259924STRING: ENSP00000225992
    RGS4ENSP000003971814STRING: ENSP00000397181
    RXFP4ENSP000003573014STRING: ENSP00000357301
    SSTENSP000002876414STRING: ENSP00000287641
    SSTR1ENSP000002673774STRING: ENSP00000267377
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR3ENSP000003301384STRING: ENSP00000330138
    SSTR4ENSP000002550084STRING: ENSP00000255008
    SSTR5ENSP000002938974STRING: ENSP00000293897
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADORA3ENSP000003587304STRING: ENSP00000358730
    AGTR2ENSP000003609734STRING: ENSP00000360973
    ANXA1ENSP000002574974STRING: ENSP00000257497
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    C3ENSP000002459074STRING: ENSP00000245907
    C5ENSP000002236424STRING: ENSP00000223642
    CASRENSP000002961544STRING: ENSP00000296154
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR8ENSP000003264324STRING: ENSP00000326432
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR6ENSP000003044144STRING: ENSP00000304414
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNG2ENSP000003344484STRING: ENSP00000334448
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR5AENSP000002879074STRING: ENSP00000287907
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NPBENSP000003327664STRING: ENSP00000332766
    OPRL1ENSP000003367644STRING: ENSP00000336764
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0002793positive regulation of peptide secretion IEA--
    GO:0003151outflow tract morphogenesis IMP19593212
    GO:0003214cardiac left ventricle morphogenesis IMP19593212
    GO:0007186G-protein coupled receptor signaling pathway ----

    NPY2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for NPY2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    1 DrugBank Compound for NPY2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 19)60-23-1targetother/unknown1314592

    Selected IUPHAR Ligands for NPY2R (Y2 receptor) (see all 27)    About this table
    LigandTypeActionAffinityPubmed IDs
    peptide YY
    AgonistFull agonist9.5 - 9.88632753 7592910
    PYY-(3-36)
    AgonistFull agonist9.2 - 9.78632753 7592910
    [125I]PYY
    AgonistFull agonist9.67559383
    neuropeptide Y
    AgonistFull agonist9.3 - 9.58632753 7592910
    peptide YY
    AgonistFull agonist9.57592910
    PYY-(13-36) (mouse, rat, pig)
    AgonistFull agonist8.8 - 9.48632753 7592910
    NPY-(2-36) (pig)
    AgonistFull agonist8.6 - 9.38632753 7592910
    NPY
    AgonistFull agonist9.1 - 9.38632753 7592910
    NPY-(3-36) (pig)
    AgonistFull agonist9.28632753
    [125I]NPY
    AgonistFull agonist9.27559383

    4 Novoseek inferred chemical compound relationships for NPY2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biie0246 87.7 1 19837904 (1)
    calcium 9.23 4 8914576 (2), 11287092 (1), 9031749 (1)
    alanine 0 1 16319069 (1)
    norepinephrine 0 2 8750699 (1)



    NPY2R for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPY2R gene: 
    NM_000910.2  

    Unigene Cluster for NPY2R:

    Neuropeptide Y receptor Y2
    Hs.37125  [show with all ESTs]
    Unigene Representative Sequence: NM_000910
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329476(uc003ioq.3) ENST00000506608(uc003ior.3)
    miRNA
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    Additional mRNA sequence: 

    BC075052.2 BC075053.2 BC096833.1 U32500.1 U36269.1 U42389.1 U42766.1 

    2 DOTS entries:

    DT.92415971  DT.95254273 

    12 AceView cDNA sequences:

    BQ716967 U36269 U32500 BC075052 CF147774 NM_000910 U42766 BC075053 
    BX283363 U42389 AL138032 BF312604 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NPY2R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPY2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTATTAGT
    NPY2R Expression
    About this image


    NPY2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Spinal Cord (Nervous System)
    NPY2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37125

    UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146
    Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable
    in caudate nucleus, hypothalamus and substantia nigra

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY2R: 
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              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPY2R gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npy2r1 , 5 neuropeptide Y receptor Y21, 5 87.89(n)1
    94.74(a)1
      3 (36.49 cM)5
    181671  NM_008731.31  NP_032757.21 
     825383835 
    chicken
    (Gallus gallus)
    Aves NPY2R1 neuropeptide Y receptor Y2 74.56(n)
    81.32(a)
      422405  NM_001031128.1  NP_001026299.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY2R6
    neuropeptide Y receptor Y2
    72(a)
    1 ↔ 1
    5(129923776-129924927)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npy2r1 neuropeptide Y receptor Y2 66.58(n)
    72.09(a)
      100498351  XM_004911153.1  XP_004911210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npy2rl1 neuropeptide Y receptor Y2, like 68.5(n)
    70.12(a)
      795311  XM_001332723.3  XP_001332759.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR13 G-protein coupled receptor protein
    signaling pathway more
    35(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y59H11AL.13
    npr-61
    npr-61 30(a)
    (best of 2)3
    46.88(n)1
    36.75(a)1
      IV(8559654-8562984)3
    1856231  NM_077324.51  NP_509725.21 


    ENSEMBL Gene Tree for NPY2R (if available)
    TreeFam Gene Tree for NPY2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPY2R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    16 SIMAP similar genes for NPY2R using alignment to 1 protein entry:     NPY2R_HUMAN:
    DRD3    GPR83    NPFFR2    PRLHR    NPFFR1    QRFPR
    BRS3    GALR1    NPY1R    PROKR1    PROKR2    TACR1
    NPY4R    PPYR1    TACR3    TACR2

    NPY2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPY2R (see all 235)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868705151,2
    --155920154(+) ATAAAA/GTGTGT 1 -- int10--------
    rs1914083051,2
    --155920264(+) TGGTCA/GTTGTT 1 -- int10--------
    rs68502891,2
    C,F--155920312(+) GGTATA/GTGGTT 1 -- int1 tfbs38Minor allele frequency- G:0.28NA WA EA 368
    rs43331361,2
    C,F,A,H--155920330(+) CACCAG/ATGCAG 1 -- int1 tfbs326Minor allele frequency- A:0.44NA NS EA WA CSA 2492
    rs578695231,2
    C,F--155920425(+) AACAAA/GACAAA 1 -- int13Minor allele frequency- G:0.11WA 122
    rs68512221,2
    C,F--155920456(+) AAGTGG/AAACTG 1 -- int19Minor allele frequency- A:0.36NA CSA WA EA 370
    rs102129381,2
    C,F,H--155920613(+) AAAAAT/CGCCTT 1 -- int110Minor allele frequency- C:0.07NS EA NA CSA WA 1200
    rs1836199991,2
    --155920631(+) CAATAC/TTATTA 1 -- int10--------
    rs1879277291,2
    --155920687(+) GGAAGC/TCTTTA 1 -- int10--------
    rs170326381,2
    C,F,H--155920760(+) AGTAGC/TGGAAT 1 -- int18Minor allele frequency- T:0.01NA NS EA 648

    HapMap Linkage Disequilibrium report for NPY2R (156129781 - 156138230 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NPY2R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880309CNV Loss21882294
    nsv881190CNV Loss21882294
    dgv5785n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NPY2R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY2R
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162642    OMIM disorders: --

    17 diseases for NPY2R:    
    About MalaCards
    cocaine dependence    pertussis    panic disorder    autism spectrum disorder
    alcohol dependence    anorexia nervosa    diabetic retinopathy    obesity
    neuroblastoma    schizophrenia    hypertension    retinitis
    malaria    endotheliitis    cerebritis    pancreatitis
    alzheimer's disease


    NPY2R for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NPY2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 20.8 12 17235527 (6), 17019604 (1), 19837904 (1)

    Genetic Association Database (GAD): NPY2R
    Human Genome Epidemiology (HuGE) Navigator: NPY2R (26 documents)

    Export disorders for NPY2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPY2R gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with NPY2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PubMed id 7559383)1, 2, 3 Rose P.M.... Seethala R. (J. Biol. Chem. 1995)
    2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)1, 4, 9 Siddiq A....Froguel P. (Diabetologia 2007)
    3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 4, 9 Campbell C.D....Hirschhorn J.N. (Diabetes 2007)
    4. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PubMed id 17019604)1, 4, 9 Torekov S.S....Pedersen O. (Diabetologia 2006)
    5. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PubMed id 8632753)1, 2, 9 Gehlert D.R.... Gadski R.A. (Mol. Pharmacol. 1996)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. (PubMed id 20811389)1, 4 Sato N....Sugimura H. (J. Hum. Genet. 2010)
    8. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)1, 4 Friedlander Y....Siscovick D.S. (Ann. Hum. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PubMed id 19759915)1, 4 Elbers C.C....Onland-Moret N.C. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4887 HGNC: 7957 AceView: NPY2R Ensembl:ENSG00000185149 euGenes: HUgn4887
    ECgene: NPY2R Kegg: 4887 H-InvDB: NPY2R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPY2R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPY2R gene:
    Search GeneIP for patents involving NPY2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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