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NPY2R Gene(Protein Coding)

Neuropeptide Y Receptor Y2

GCID:
GC04P155173
GIFtS:
64
Genes Participants
UDN Logo

Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3 5
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Y2 Receptor 4

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and calcium channel regulator activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

Products:

  1. Regulatory Element

Regulatory Elements for NPY2R Gene

Enhancers for NPY2R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPY2R on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NPY2R gene promoter:

Genomic Location for NPY2R Gene

Chromosome:
4
Start:
155,173,754 bp from pter
End:
155,217,096 bp from pter
Size:
43,343 bases
Orientation:
Plus strand

Genomic View for NPY2R Gene

Genes around NPY2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49146-NPY2R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    P49146
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    Size:
    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Proteomics data for NPY2R Gene at MOPED

Post-translational modifications for NPY2R Gene

  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPY2R Gene

Domains & Families for NPY2R Gene

Gene Families for NPY2R Gene

HGNC:
IUPHAR :

Protein Domains for NPY2R Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49146

UniProtKB/Swiss-Prot:

NPY2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NPY2R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Phenotypes for NPY2R Gene

MGI mutant phenotypes for NPY2R:
inferred from 3 alleles
GenomeRNAi human phenotypes for NPY2R:
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPY2R

miRNA for NPY2R Gene

miRTarBase miRNAs that target NPY2R

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPY2R Gene COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0031513 nonmotile primary cilium IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Pathways & Interactions for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

SIGNOR curated interactions for NPY2R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Drugs & Compounds for NPY2R Gene

Products:

  1. Drug

(35) Drugs for NPY2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma Target, other/unknown 26
AC162352 Investigational Pharma Target 0
TM30338 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0
BIIE0246 Pharma Antagonist 0

(6) Additional Compounds for NPY2R Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]NPY
Full agonist, Agonist
[Leu31,Pro34]-Neuropeptide Y (human, rat)
132699-73-1
[Leu31,Pro34]-Neuropeptide Y (porcine)
125580-28-1
Neuropeptide Y (human, rat)
90880-35-6
Neuropeptide Y (porcine)
83589-17-7

(5) Tocris Compounds for NPY2R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist 132699-73-1
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Neuropeptide Y (porcine) Influences feeding and sexual behavior 83589-17-7
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(1) ApexBio Compounds for NPY2R Gene

Compound Action Cas Number
Peptide YY(3-36), PYY, human Y2R agonist 123583-37-9
genes like me logo Genes that share compounds with NPY2R: view

Transcripts for NPY2R Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NPY2R Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY2R Gene

Neuropeptide Y receptor Y2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for
NPY2R
ECgene alternative splicing isoforms for
NPY2R

Expression for NPY2R Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NPY2R Gene

mRNA expression in normal human tissues for NPY2R Gene
mRNA expression by BioGPS for NPY2R GenemRNA expression by GTEx for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Hippocampus (x4.5), Brain - Spinal cord (cervical c-1) (x4.5), and Brain - Amygdala (x4.1).

SOURCE GeneReport for Unigene cluster for NPY2R Gene Hs.37125

mRNA Expression by UniProt/SwissProt for NPY2R Gene

P49146-NPY2R_HUMAN
Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.
genes like me logo Genes that share expression patterns with NPY2R: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia NPY2R 35
  • 90.03 (n)
  • 95.01 (a)
NPY2R 36
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia NPY2R 35
  • 91.16 (n)
  • 94.47 (a)
mouse
(Mus musculus)
 Mammalia Npy2r 35
  • 87.89 (n)
  • 94.74 (a)
Npy2r 16
Npy2r 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia NPY2R 35
  • 99.56 (n)
  • 100 (a)
NPY2R 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Npy2r 35
  • 86.84 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
 Mammalia NPY2R 36
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NPY2R 36
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NPY2R 35
  • 74.56 (n)
  • 81.32 (a)
NPY2R 36
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NPY2R 36
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia npy2r 35
  • 66.58 (n)
  • 72.09 (a)
zebrafish
(Danio rerio)
 Actinopterygii npy2rl 35
  • 68.5 (n)
  • 70.12 (a)
npy2r 36
  • 54 (a)
 OneToMany
npy2rl 36
  • 62 (a)
 OneToMany
npy2rl 36
  • 62 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 33 (a)
NPFR1 37
  • 35 (a)
NPFR1 36
  • 22 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta GPRNPY3 35
  • 49.67 (n)
  • 38.49 (a)
worm
(Caenorhabditis elegans)
 Secernentea F41E7.3 37
  • 30 (a)
Y59H11AL.1 37
  • 30 (a)
npr-6 35
  • 46.88 (n)
  • 36.75 (a)
npr-11 36
  • 26 (a)
 ManyToMany
npr-12 36
  • 20 (a)
 ManyToMany
Species with no ortholog for NPY2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY2R Gene

ENSEMBL:
Gene Tree for NPY2R (if available)
TreeFam:
Gene Tree for NPY2R (if available)

Paralogs for NPY2R Gene

Paralogs for NPY2R Gene

(16) SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Sequence variations from dbSNP and Humsavar for NPY2R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1047214 -- 155,214,524(+) ATCAT(C/T)CCGGA reference, synonymous-codon
rs1317359 -- 155,212,069(+) GGAAC(A/G)GTGAG intron-variant
rs1574175 -- 155,212,560(-) CTGGC(A/G)CCTTT intron-variant
rs1574176 -- 155,212,338(-) GATGT(A/T)TTTTT intron-variant
rs1876210 -- 155,177,286(+) atcaa(A/G)caagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
dgv5785n71 CNV Loss 21882294
nsv881190 CNV Loss 21882294
nsv880309 CNV Loss 21882294

Variation tolerance for NPY2R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY2R Gene

Human Gene Mutation Database (HGMD)
NPY2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY2R Gene

Disorders for NPY2R Gene

Relevant External Links for NPY2R

Genetic Association Database (GAD)
NPY2R
Human Genome Epidemiology (HuGE) Navigator
NPY2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY2R

No disorders were found for NPY2R Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY2R Gene

Publications for NPY2R Gene

  1. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PMID: 7559383) Rose P.M. … Seethala R. (J. Biol. Chem. 1995) 2 3 4 67
  2. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. (PMID: 18700141) Parker S.L. … Sallee F. (Eur. J. Pharmacol. 2008) 3 23
  3. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A. … Froguel P. (Diabetologia 2007) 3 23
  4. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23
  5. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PMID: 17019604) Torekov S.S. … Pedersen O. (Diabetologia 2006) 3 23

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