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NPY2R Gene(Protein Coding)

Neuropeptide Y Receptor Y2

GCID:
GC04P155173
GIFtS:
53
Genes Participants
UDN Logo

Aliases for NPY2R Gene

Aliases for NPY2R Gene

  • Neuropeptide Y Receptor Y2 2 3 5
  • NPY-Y2 Receptor 3 4
  • NPY2-R 3 4
  • Neuropeptide Y Receptor Type 2 3
  • Y2 Receptor 4

External Ids for NPY2R Gene

Previous GeneCards Identifiers for NPY2R Gene

  • GC04P157017
  • GC04P156557
  • GC04P156707
  • GC04P156671
  • GC04P156487
  • GC04P156349
  • GC04P156129
  • GC04P151868

Summaries for NPY2R Gene

GeneCards Summary for NPY2R Gene

NPY2R (Neuropeptide Y Receptor Y2) is a Protein Coding gene. Diseases associated with NPY2R include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and calcium channel regulator activity. An important paralog of this gene is NPY4R.

UniProtKB/Swiss-Prot for NPY2R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Tocris Summary for NPY2R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY2R Gene

Additional gene information for NPY2R Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY2R Gene

Genomics for NPY2R Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NPY2R Gene

Promoters and enhancers for NPY2R Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I155208 Promoter 0.8 EPDnew 550.3 +34.9 34863 0.1 CTCF GLIS2 ZBTB48 EZH2 LOC107986321 NPY2R LOC102724776
GH04I155818 Enhancer 0.4 ENCODE 5.8 +645.3 645338 0.8 ZNF316 MAFK TDO2 NPY2R GC04M155710
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPY2R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPY2R gene promoter:

Genomic Locations for NPY2R Gene

Genomic Locations for NPY2R Gene
chr4:155,173,754-155,217,096
(GRCh38/hg38)
Size:
43,343 bases
Orientation:
Plus strand
chr4:156,129,781-156,138,230
(GRCh37/hg19)

Genomic View for NPY2R Gene

Genes around NPY2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY2R Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NPY2R Gene

Proteins for NPY2R Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NPY2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49146-NPY2R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 2
    Protein Accession:
    P49146
    Secondary Accessions:
    • Q13281
    • Q13457
    • Q4W5G7
    • Q6AZZ6
    • Q9UE67

    Protein attributes for NPY2R Gene

    Size:
    381 amino acids
    Molecular mass:
    42731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY2R Gene

neXtProt entry for NPY2R Gene

Post-translational modifications for NPY2R Gene

Other Protein References for NPY2R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPY2R Gene

Domains & Families for NPY2R Gene

Gene Families for NPY2R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NPY2R Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NPY2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49146

UniProtKB/Swiss-Prot:

NPY2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY2R: view

Function for NPY2R Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NPY2R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the hippocampus,involved in the presynaptic inhibition of neurotransmitter release
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Phenotypes From GWAS Catalog for NPY2R Gene

Gene Ontology (GO) - Molecular Function for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity TAS 1321422
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity TAS 7559383
genes like me logo Genes that share ontologies with NPY2R: view
genes like me logo Genes that share phenotypes with NPY2R: view

Animal Models for NPY2R Gene

MGI Knock Outs for NPY2R:

Animal Model Products

miRNA for NPY2R Gene

miRTarBase miRNAs that target NPY2R

Clone Products

  • Addgene plasmids for NPY2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY2R Gene

Localization for NPY2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY2R gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPY2R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPY2R Gene

Pathways & Interactions for NPY2R Gene

genes like me logo Genes that share pathways with NPY2R: view

SIGNOR curated interactions for NPY2R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0002793 positive regulation of peptide secretion IEA --
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with NPY2R: view

Drugs & Compounds for NPY2R Gene

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  1. Drug

(52) Drugs for NPY2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide Y Approved, Investigational Pharma Full agonist, Agonist 0
Cysteamine Approved, Investigational Pharma Target, other/unknown 27
Obinepitide Investigational Pharma Target 0
AC162352 Investigational Pharma Target 0
PYY3-36 Investigational Pharma agonist 0

(2) Additional Compounds for NPY2R Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]NPY
Full agonist, Agonist
Neuropeptide Y (human, rat)
90880-35-6

(5) Tocris Compounds for NPY2R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) NPY Y1 receptor agonist 125580-28-1
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist
GR 231118 Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors 158859-98-4
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6
Pancreatic Polypeptide (human) NPY Y4 agonist; involved in gastrointestinal tract function 75976-10-2

(18) ApexBio Compounds for NPY2R Gene

Compound Action Cas Number
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide 313988-89-5
[D-Trp34]-Neuropeptide Y 153549-84-9
[Leu31,Pro34]-Neuropeptide Y (human, rat) 132699-73-1
BIIE 0246 NPY Y2 receptor antagonist 246146-55-4
CGP 71683 hydrochloride 192322-50-2
CYM 9484 1383478-94-1
GR 231118 158859-98-4
JNJ 5207787 683746-68-1
L-152,804 6508-43-6
LU AA33810 304008-29-5
Neuropeptide Y (scrambled) control in the research in NPY
NPY 5RA972 439861-56-0
NTNCB hydrochloride 191931-56-3
Pancreatic Polypeptide (human) 75976-10-2
PD 160170 181468-88-2
Peptide YY(3-36), PYY, human Y2R agonist 123583-37-9
S 25585 263849-50-9
SF 11 443292-81-7
genes like me logo Genes that share compounds with NPY2R: view

Drug Products

Transcripts for NPY2R Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NPY2R Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY2R Gene

Neuropeptide Y receptor Y2:
Representative Sequences:

Clone Products

  • Addgene plasmids for NPY2R

Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for NPY2R Gene

GeneLoc Exon Structure for
NPY2R
ECgene alternative splicing isoforms for
NPY2R

Expression for NPY2R Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPY2R Gene

mRNA expression in normal human tissues for NPY2R Gene
mRNA expression by BioGPS for NPY2R GenemRNA expression by GTEx for NPY2R Gene

mRNA differential expression in normal tissues according to GTEx for NPY2R Gene

This gene is overexpressed in Brain - Hypothalamus (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Hippocampus (x4.5), Brain - Spinal cord (cervical c-1) (x4.5), and Brain - Amygdala (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of NPY2R Gene:

NPY2R

SOURCE GeneReport for Unigene cluster for NPY2R Gene:

Hs.37125

mRNA Expression by UniProt/SwissProt for NPY2R Gene:

P49146-NPY2R_HUMAN
Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Evidence on tissue expression from TISSUES for NPY2R Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with NPY2R: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY2R Gene

Orthologs for NPY2R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NPY2R 34 33
  • 99.56 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NPY2R 33
  • 91.16 (n)
cow
(Bos Taurus)
 Mammalia NPY2R 34 33
  • 90.03 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NPY2R 34
  • 89 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Npy2r 34 16 33
  • 87.89 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Npy2r 33
  • 86.84 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NPY2R 34
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NPY2R 34 33
  • 74.56 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NPY2R 34
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia npy2r 33
  • 66.58 (n)
zebrafish
(Danio rerio)
 Actinopterygii npy2rl 33 34 34
  • 68.5 (n)
npy2r 34
  • 54 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta GPRNPY3 33
  • 49.67 (n)
fruit fly
(Drosophila melanogaster)
 Insecta NPFR1 35 34
  • 35 (a)
NepYr 35
  • 33 (a)
CG10626 35
  • 32 (a)
worm
(Caenorhabditis elegans)
 Secernentea npr-6 33
  • 46.88 (n)
F41E7.3 35
  • 30 (a)
Y59H11AL.1 35
  • 30 (a)
npr-11 34
  • 26 (a)
 ManyToMany
npr-12 34
  • 20 (a)
 ManyToMany
Species where no ortholog for NPY2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY2R Gene

ENSEMBL:
Gene Tree for NPY2R (if available)
TreeFam:
Gene Tree for NPY2R (if available)

Paralogs for NPY2R Gene

Paralogs for NPY2R Gene

(16) SIMAP similar genes for NPY2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPY2R: view

Variants for NPY2R Gene

Sequence variations from dbSNP and Humsavar for NPY2R Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000137 -- 155,181,024(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000036453 -- 155,174,548(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000321408 -- 155,190,921(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000330070 -- 155,180,232(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000336651 -- 155,183,024(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPY2R Gene

Variant ID Type Subtype PubMed ID
nsv1136916 CNV deletion 24896259

Variation tolerance for NPY2R Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPY2R Gene

Human Gene Mutation Database (HGMD)
NPY2R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY2R Gene

Disorders for NPY2R Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPY2R Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NPY2R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPY2R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPY2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY2R Gene

Publications for NPY2R Gene

  1. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PMID: 17235527) Siddiq A … Froguel P (Diabetologia 2007) 3 22 44 58
  2. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell CD … Hirschhorn JN (Diabetes 2007) 3 22 44 58
  3. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PMID: 17019604) Torekov SS … Pedersen O (Diabetologia 2006) 3 22 44 58
  4. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PMID: 8632753) Gehlert DR … Gadski RA (Molecular pharmacology 1996) 3 4 22 58
  5. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PMID: 7559383) Rose PM … Seethala R (The Journal of biological chemistry 1995) 2 3 4 58

Products for NPY2R Gene

  • Addgene plasmids for NPY2R

Sources for NPY2R Gene

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