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NPY2R Gene

protein-coding GIFtS: 66
GCID: GC04P156129

Neuropeptide Y Receptor Y2

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Neuropeptide Y Receptor Y2¹ ²
NPY2-R² ³
NPY-Y2 Receptor² ³
Y2 Receptor² ³
Neuropeptide Y Receptor Type 2²

External Ids:	HGNC: 7957¹	Entrez Gene: 4887²	Ensembl: ENSG00000185149⁷	OMIM: 162642⁵	UniProtKB: P49146³

Export aliases for NPY2R gene to outside databases

Previous GC identifers: GC04P157017 GC04P156557 GC04P156707 GC04P156671 GC04P156487 GC04P156349 GC04P151868

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPY2R Gene:

NPY2R (neuropeptide Y receptor Y2) is a protein-coding gene. Diseases associated with NPY2R include cocaine dependence, and pertussis. GO annotations related to this gene include neuropeptide Y receptor activity and receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146

Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic

polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]

PYY and NPY free acid

summary for NPY2R Gene:

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided

into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including

stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of

pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and

colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding

Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on

chromosome 10q11.2.

Gene Wiki entry for NPY2R (Neuropeptide Y receptor Y2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NT_016354.20 NC_018915.2

Regulatory elements:

Regulatory transcription factor binding sites in the NPY2R gene promoter:
Nkx3-1 AML1a Brachyury Nkx3-1 v1 RelA Nkx3-1 v2 NRF-2 Nkx3-1 v3 Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPY2R promoter sequence

Search Chromatin IP Primers for NPY2R

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY2R

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q31

NPY2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY2R gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P156129: view genomic region (about GC identifiers)

Start:	156,129,781 bp from pter	End:	156,138,230 bp from pter
Size:	8,450 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146 (See protein sequence)

Recommended Name: Neuropeptide Y receptor type 2

Size: 381 amino acids; 42731 Da

1 PDB 3D structure from and Proteopedia for NPY2R:

2IK3 (3D)

Secondary accessions: Q13281 Q13457 Q4W5G7 Q6AZZ6 Q9UE67

Explore the universe of human proteins at neXtProt for NPY2R: NX_P49146

Explore proteomics data for NPY2R at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NPY2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000901.1

ENSEMBL proteins:

ENSP00000332591 ENSP00000426366

Reactome Protein details: P49146

NPY2R Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

NPYR: GPCR / Class A : Neuropeptide receptors : Y

IUPHAR Guide to PHARMACOLOGY protein family classification: Y₂ receptor

Neuropeptide Y receptors

4 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR000611 NPY_rcpt

IPR001358 NPY2_rcpt

Graphical View of Domain Structure for InterPro Entry P49146

ProtoNet protein and cluster: P49146

2 Blocks protein domains:

IPB000611 Neuropeptide Y receptor signature

IPB001358 Neuropeptide Y2 receptor signature

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146

Similarity: Belongs to the G-protein coupled receptor 1 family

NPY2R for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NPY2R_HUMAN, P49146

Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic

polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34]

PYY and NPY free acid

Genatlas biochemistry entry for NPY2R:

neuropeptide Y receptor Y2 rhodopsin-like,G protein coupled receptor superfamily,expressed in the

hippocampus,involved in the presynaptic inhibition of neurotransmitter release

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001601	peptide YY receptor activity	IEA	--
GO:0004872	receptor activity	TAS	1321422
GO:0004930	G-protein coupled receptor activity	--	--
GO:0004983	neuropeptide Y receptor activity	TAS	7559383
GO:0005246	calcium channel regulator activity	TAS	8132547

NPY2R for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NPY2R:

Increased gamma-H2AX phosphory

Selected MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Npy2r) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	endocrine/exocrine gland	growth/size/body	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	nervous system	renal/urinary system

NPY2R for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Npy2r^tm1.1Hhz for NPY2R

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY2R

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY2R

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		SwitchGear 3'UTR luciferase reporter plasmid: NPY2R 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NPY2R_HUMAN, P49146: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
cytosol	1
nucleus	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	--	--

NPY2R for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NPY2R About

See pathways by source

SuperPath

Contained pathways About

Peptide ligand-binding receptors

Class A/1 (Rhodopsin-like receptors)	0.71	G alpha (i) signalling events	0.44
GPCR ligand binding	0.71	GPCRs, Class A Rhodopsin-like	0.43
Peptide ligand-binding receptors	0.60	Neuroactive ligand-receptor interaction	0.36

Neuropeptides signaling through G protein alpha i and G protein alpha q

Peptide GPCRs

0.46

Neuropeptides signaling through G protein alpha i and G protein alpha q

0.46

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for NPY2R

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

2 Reactome Pathways for NPY2R

	Peptide ligand-binding receptors
	G alpha (i) signalling events

1 PharmGKB Pathway for NPY2R

Sympathetic Nerve Pathway (Neuroeffector Junction)

1 Kegg Pathway (Kegg details for NPY2R):

Neuroactive ligand-receptor interaction

NPY2R for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including NPY2R:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Neurotrophins & Receptors in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for NPY2R

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NPY2R (P49146^{1, 3} ENSP00000332591⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 145)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPY	P01303³, ENSP00000242152⁴	I2D: score=1 STRING: ENSP00000242152
RGS12	O14924³, ENSP00000339381⁴	I2D: score=1 STRING: ENSP00000339381
PYY	P10082¹, ENSP00000353198⁴	EBI-6655721,EBI-6655667 STRING: ENSP00000353198
SQSTM1	Q13501³	I2D: score=1
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): Selected biological process terms (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001662	behavioral fear response	IEA	--
GO:0002793	positive regulation of peptide secretion	IEA	--
GO:0003151	outflow tract morphogenesis	IMP	19593212
GO:0003214	cardiac left ventricle morphogenesis	IMP	19593212
GO:0007186	G-protein coupled receptor signaling pathway	--	--

NPY2R for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for NPY2R available from Tocris Bioscience About this table

Compound	Action	CAS #
BIIE 0246	Potent, selective non-peptide NPY Y2 receptor antagonist	[246146-55-4]
[Leu31,Pro34]-Neuropeptide Y (human, rat)	NPY Y1 receptor agonist	[132699-73-1]
BIBP 3226 trifluoroacetate	Mixed NPY Y1 and NPFF receptor antagonist	[159013-54-4]
Neuropeptide Y (human, rat)	Influences feeding and sexual behavior	[90880-35-6]
BIBO 3304 trifluoroacetate	Highly selective NPY Y1 receptor antagonist	[191868-14-1]

1 DrugBank Compound for NPY2R About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cysteamine	(2-Mercaptoethyl)amine 2-Amino-1-ethanethiol 2-Aminoethanethiol 2-Aminoethyl mercaptan 2-Mercaptoethanamine Aminoethyl mercaptan beta-Aminoethanethiol beta-MEA beta-Mercaptoethylamine Cisteamina Cysteamide Cysteamin Cysteinamine Decarboxycysteine Ethanethiolamine MEA Mercamine Mercaptamin Thioethanolamine (see top 1)	60-23-1	target	other/unknown	1314592

Selected IUPHAR Ligands for NPY2R (Y₂ receptor) (see all 27) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
peptide YY	Agonist	Full agonist	9.5 - 9.8	8632753 7592910
PYY-(3-36)	Agonist	Full agonist	9.2 - 9.7	8632753 7592910
[¹²⁵I]PYY	Agonist	Full agonist	9.6	7559383
neuropeptide Y	Agonist	Full agonist	9.3 - 9.5	8632753 7592910
peptide YY	Agonist	Full agonist	9.5	7592910
PYY-(13-36) (mouse, rat, pig)	Agonist	Full agonist	8.8 - 9.4	8632753 7592910
NPY-(2-36) (pig)	Agonist	Full agonist	8.6 - 9.3	8632753 7592910
NPY	Agonist	Full agonist	9.1 - 9.3	8632753 7592910
NPY-(3-36) (pig)	Agonist	Full agonist	9.2	8632753
[¹²⁵I]NPY	Agonist	Full agonist	9.2	7559383

4 Novoseek inferred chemical compound relationships for NPY2R gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
biie0246	87.7	1	19837904 (1)
calcium	9.23	4	8914576 (2), 11287092 (1), 9031749 (1)
alanine	0	1	16319069 (1)
norepinephrine	0	2	8750699 (1)

NPY2R for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NPY2R gene:

NM_000910.2

Unigene Cluster for NPY2R:

Neuropeptide Y receptor Y2

Hs.37125 [show with all ESTs]

Unigene Representative Sequence: NM_000910

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000329476(uc003ioq.3) ENST00000506608(uc003ior.3)

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		7 qRT-PCR Assays for microRNAs that regulate NPY2R:
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		SwitchGear 3'UTR luciferase reporter plasmid: NPY2R 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: NPY2R (NM_000910)
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NPY2R
		QuantiTect SYBR Green Assays in human, mouse, rat NPY2R
		QuantiFast Probe-based Assays in human, mouse, rat NPY2R

Additional mRNA sequence:

BC075052.2 BC075053.2 BC096833.1 U32500.1 U36269.1 U42389.1 U42766.1

2 DOTS entries:

DT.92415971 DT.95254273

12 AceView cDNA sequences:

BQ716967 U36269 U32500 BC075052 CF147774 NM_000910 U42766 BC075053

BX283363 U42389 AL138032 BF312604

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NPY2R About this scheme

ExUns:	1a	·	1b	^	2a	·	2b
SP1:
SP2:

ECgene alternative splicing isoforms for NPY2R

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPY2R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGTATTAGT

About this image

NPY2R expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Brain (Nervous System) fully expand to see all 21 entries
Thalamus
Substantia Nigra

Neural Tube (Nervous System)
Spinal Ventral Columns

Spinal Cord (Nervous System)

NPY2R Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NPY2R Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.37125

UniProtKB/Swiss-Prot: NPY2R_HUMAN, P49146

Tissue specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable

in caudate nucleus, hypothalamus and substantia nigra

Pathway & Disease-focused RT² Profiler PCR Arrays including NPY2R:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Neurotrophins & Receptors in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for NPY2R OriGene qSTAR qPCR primer pairs in human, mouse for NPY2R
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		QuantiFast Probe-based Assays in human, mouse, rat NPY2R

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NPY2R gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Npy2r^{1 , 5}	neuropeptide Y receptor Y2^{1, 5}	87.89(n)¹ 94.74(a)¹		3 (36.49 cM)⁵ 18167¹ NM_008731.3¹ NP_032757.2¹ 82538383⁵
chicken (Gallus gallus)	Aves	NPY2R¹	neuropeptide Y receptor Y2	74.56(n) 81.32(a)		422405 NM_001031128.1 NP_001026299.1
lizard (Anolis carolinensis)	Reptilia	NPY2R⁶	neuropeptide Y receptor Y2	72(a)	1 ↔ 1	5(129923776-129924927)
tropical clawed frog (Xenopus tropicalis)	Amphibia	npy2r¹	neuropeptide Y receptor Y2	66.58(n) 72.09(a)		100498351 XM_004911153.1 XP_004911210.1
zebrafish (Danio rerio)	Actinopterygii	npy2rl¹	neuropeptide Y receptor Y2, like	68.5(n) 70.12(a)		795311 XM_001332723.3 XP_001332759.1
fruit fly (Drosophila melanogaster)	Insecta	NPFR1³	G-protein coupled receptor protein signaling pathway more	35(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	Y59H11AL.1³ npr-6¹	npr-6¹	30(a) (best of 2)³ 46.88(n)¹ 36.75(a)¹		IV(8559654-8562984)³ 185623¹ NM_077324.5¹ NP_509725.2¹

ENSEMBL Gene Tree for NPY2R (if available)
TreeFam Gene Tree for NPY2R (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NPY2R gene

GPR83² HCRTR2² PRLHR² NPFFR2² NPY5R² NPY4R² TACR1² TACR3²

NPY1R² NPFFR1² QRFPR² HCRTR1² TACR2²

16 SIMAP similar genes for NPY2R using alignment to 1 protein entry: NPY2R_HUMAN:

DRD3 GPR83 NPFFR2 PRLHR NPFFR1 QRFPR

BRS3 GALR1 NPY1R PROKR1 PROKR2 TACR1

NPY4R PPYR1 TACR3 TACR2

NPY2R for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186870515^1,2		--	155920154(+)	`ATAAAA/GTGTGT`	1	--	int¹		0	--	--	--	--
rs191408305^1,2		--	155920264(+)	`TGGTCA/GTTGTT`	1	--	int¹		0	--	--	--	--
rs6850289^1,2	C,F	--	155920312(+)	`GGTATA/GTGGTT`	1	--	int¹ tfbs³		8		NA WA EA	368
rs4333136^1,2	C,F,A,H	--	155920330(+)	`CACCAG/ATGCAG`	1	--	int¹ tfbs³		26		NA NS EA WA CSA	2492
rs57869523^1,2	C,F	--	155920425(+)	`AACAAA/GACAAA`	1	--	int¹		3		WA	122
rs6851222^1,2	C,F	--	155920456(+)	`AAGTGG/AAACTG`	1	--	int¹		9		NA CSA WA EA	370
rs10212938^1,2	C,F,H	--	155920613(+)	`AAAAAT/CGCCTT`	1	--	int¹		10		NS EA NA CSA WA	1200
rs183619999^1,2		--	155920631(+)	`CAATAC/TTATTA`	1	--	int¹		0	--	--	--	--
rs187927729^1,2		--	155920687(+)	`GGAAGC/TCTTTA`	1	--	int¹		0	--	--	--	--
rs17032638^1,2	C,F,H	--	155920760(+)	`AGTAGC/TGGAAT`	1	--	int¹		8		NA NS EA	648

HapMap Linkage Disequilibrium report for NPY2R (156129781 - 156138230 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for NPY2R: About this table

Variant ID	Type	Subtype	PubMed ID
nsv880309	CNV	Loss	21882294
nsv881190	CNV	Loss	21882294
dgv5785n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): NPY2R

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162642 OMIM disorders: --

17 diseases for NPY2R:
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cocaine dependence pertussis panic disorder autism spectrum disorder

alcohol dependence anorexia nervosa diabetic retinopathy obesity

neuroblastoma schizophrenia hypertension retinitis

malaria endotheliitis cerebritis pancreatitis

alzheimer's disease

NPY2R for disorders About GeneDecksing

1 Novoseek inferred disease relationship for NPY2R gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	20.8	12	17235527 (6), 17019604 (1), 19837904 (1)

Genetic Association Database (GAD): NPY2R
Human Genome Epidemiology (HuGE) Navigator: NPY2R (26 documents)

Export disorders for NPY2R gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPY2R gene, integrated from 10 sources (see all 113):
(articles sorted by number of sources associating them with NPY2R)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PubMed id 7559383)^{1, 2, 3} Rose P.M.... Seethala R. (J. Biol. Chem. 1995)
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)^{1, 4, 9} Siddiq A....Froguel P. (Diabetologia 2007)
Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)^{1, 4, 9} Campbell C.D....Hirschhorn J.N. (Diabetes 2007)
Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PubMed id 17019604)^{1, 4, 9} Torekov S.S....Pedersen O. (Diabetologia 2006)
Expression cloning of a human brain neuropeptide Y Y2 receptor. (PubMed id 8632753)^{1, 2, 9} Gehlert D.R.... Gadski R.A. (Mol. Pharmacol. 1996)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)^{1, 4} Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. (PubMed id 20811389)^{1, 4} Sato N....Sugimura H. (J. Hum. Genet. 2010)
Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)^{1, 4} Friedlander Y....Siscovick D.S. (Ann. Hum. Genet. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PubMed id 19759915)^{1, 4} Elbers C.C....Onland-Moret N.C. (PLoS ONE 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4887	HGNC: 7957	AceView: NPY2R	Ensembl:ENSG00000185149	euGenes: HUgn4887
ECgene: NPY2R	Kegg: 4887	H-InvDB: NPY2R

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NPY2R	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NPY2R gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NPY2R gene:
Search GeneIP for patents involving NPY2R

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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NPY2R Gene

Neuropeptide Y Receptor Y2

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Neuropeptide Y Receptor Y2

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