NPY2R Gene

Aliases
for NPY2R gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04P157017 GC04P156557 GC04P156707 GC04P156671 GC04P156487 GC04P156349 GC04P151868

Summaries
for NPY2R gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for NPY2R gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NT_016354.20  NC_018915.2  

SwitchGear Promoter luciferase reporter plasmid: NPY2R promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY2R

NPY2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156129:  view genomic region     (about GC identifiers)

Proteins
for NPY2R gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for NPY2R:

2IK3 (3D)    

Explore the universe of human proteins at neXtProt for NPY2R: NX_P49146

Explore proteomics data for NPY2R at MOPED

Post-translational modifications: 

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Domains /
Families
for NPY2R gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P49146

Find genes that share domains with NPY2R           About GenesLikeMe

Function
for NPY2R gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

Selected MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Npy2r)

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

Localization
for NPY2R gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for NPY2R gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for NPY2R About     See pathways by source

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	SuperPath	Contained pathways About
1	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 GPCRs, Class A Rhodopsin-like 0.43 GPCR ligand binding 0.71 Neuroactive ligand-receptor interaction 0.36 Peptide ligand-binding receptors 0.60 Peptide GPCRs 0.32 G alpha (i) signalling events 0.44
2	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90
3	Sympathetic Nerve Pathway (Neuroeffector Junction)	Sympathetic Nerve Pathway (Neuroeffector Junction)

2 BioSystems Pathways for NPY2R

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

2 Reactome Pathways for NPY2R

	Peptide ligand-binding receptors
	G alpha (i) signalling events

1 PharmGKB Pathway for NPY2R

Sympathetic Nerve Pathway (Neuroeffector Junction)

1 Kegg Pathway  (Kegg details for NPY2R)

Neuroactive ligand-receptor interaction

Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

Drugs & Compounds
for NPY2R gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for NPY2R gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for NPY2R gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPY2R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGTATTAGT

About this image

Brain (Nervous System)    fully expand to see all 21 entries
Thalamus
Substantia Nigra
Neural Tube (Nervous System)
Spinal Ventral Columns
Spinal Cord (Nervous System)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY2R

Orthologs
for NPY2R gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for NPY2R gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for NPY2R gene

GPR83²  HCRTR2²  PRLHR²  NPFFR2²  NPY5R²  NPY4R²  TACR1²  TACR3²  

NPY1R²  NPFFR1²  QRFPR²  HCRTR1²  TACR2²  

16 SIMAP similar genes for NPY2R using alignment to 1 protein entry:     NPY2R_HUMAN:

DRD3    GPR83    NPFFR2    PRLHR    NPFFR1    QRFPR

BRS3    GALR1    NPY1R    PROKR1    PROKR2    TACR1

NPY4R    PPYR1    TACR3    TACR2

Find genes that share paralogs with NPY2R           About GenesLikeMe

Genomic Variants
for NPY2R gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NPY2R (see all 235)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1868705151,2		--	155920154(+)	ATAAAA/GTGTGT	1	--	int1		0	--	--	--	--
rs1914083051,2		--	155920264(+)	TGGTCA/GTTGTT	1	--	int1		0	--	--	--	--
rs68502891,2	C,F	--	155920312(+)	GGTATA/GTGGTT	1	--	int1 tfbs3		8		NA WA EA	368
rs43331361,2	C,F,A,H	--	155920330(+)	CACCAG/ATGCAG	1	--	int1 tfbs3		26		NA NS EA WA CSA	2492
rs578695231,2	C,F	--	155920425(+)	AACAAA/GACAAA	1	--	int1		3		WA	122
rs68512221,2	C,F	--	155920456(+)	AAGTGG/AAACTG	1	--	int1		9		NA CSA WA EA	370
rs102129381,2	C,F,H	--	155920613(+)	AAAAAT/CGCCTT	1	--	int1		10		NS EA NA CSA WA	1200
rs1836199991,2		--	155920631(+)	CAATAC/TTATTA	1	--	int1		0	--	--	--	--
rs1879277291,2		--	155920687(+)	GGAAGC/TCTTTA	1	--	int1		0	--	--	--	--
rs170326381,2	C,F,H	--	155920760(+)	AGTAGC/TGGAAT	1	--	int1		8		NA NS EA	648

HapMap Linkage Disequilibrium report for NPY2R (156129781 - 156138230 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for NPY2R:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv880309	CNV	Loss	21882294
nsv881190	CNV	Loss	21882294
dgv5785n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): NPY2R

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NPY2R

DNA2.0 Custom Variant and Variant Library Synthesis for NPY2R

Disorders / Diseases
for NPY2R gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 Novoseek inferred disease relationship for NPY2R gene    About this table

Publications
for NPY2R gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPY2R gene, integrated from 10 sources (see all 113): (articles sorted by number of sources associating them with NPY2R)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. (PubMed id 7559383)^{1, 2, 3} Rose P.M.... Seethala R. (J. Biol. Chem. 1995)
2. Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. (PubMed id 17235527)^{1, 4, 9} Siddiq A....Froguel P. (Diabetologia 2007)
3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)^{1, 4, 9} Campbell C.D....Hirschhorn J.N. (Diabetes 2007)
4. Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. (PubMed id 17019604)^{1, 4, 9} Torekov S.S....Pedersen O. (Diabetologia 2006)
5. Expression cloning of a human brain neuropeptide Y Y2 receptor. (PubMed id 8632753)^{1, 2, 9} Gehlert D.R.... Gadski R.A. (Mol. Pharmacol. 1996)
6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)^{1, 4} Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
7. Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. (PubMed id 20811389)^{1, 4} Sato N....Sugimura H. (J. Hum. Genet. 2010)
8. Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. (PubMed id 20642810)^{1, 4} Friedlander Y....Siscovick D.S. (Ann. Hum. Genet. 2010)
9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
10. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PubMed id 19759915)^{1, 4} Elbers C.C....Onland-Moret N.C. (PLoS ONE 2009)

External Searches for NPY2R gene

Genome Databases showing NPY2R gene

Other Databases showing NPY2R gene

Specialized Databases showing NPY2R gene

Products
for NPY2R gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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