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NPY1R Gene

protein-coding   GIFtS: 67
GCID: GC04M164245

Neuropeptide Y Receptor Y1


(Previous symbol: NPYR)
  See NPY1R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide Y Receptor Y11 2
NPYR1 2 3
NPY1-R2 3
Neuropeptide Y Receptor Type 12
NPYY13

External Ids:    HGNC: 79561   Entrez Gene: 48862   Ensembl: ENSG000001641287   OMIM: 1626415   UniProtKB: P259293   

Export aliases for NPY1R gene to outside databases

Previous GC identifers: GC04M165094 GC04M164673 GC04M164822 GC04M164602 GC04M164464 GC04M159999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPY1R Gene:
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the
function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The
encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently
recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular
calcium and inhibition of adenylate cyclase activity. (provided by RefSeq, Aug 2013)

GeneCards Summary for NPY1R Gene:
NPY1R (neuropeptide Y receptor Y1) is a protein-coding gene. Diseases associated with NPY1R include proliferative vitreoretinopathy, and angina pectoris. GO annotations related to this gene include neuropeptide Y receptor activity and pancreatic polypeptide receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPY1R_HUMAN, P25929
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY
(3-36) > PP > NPY free acid

summary for NPY1R Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and
colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding
Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on
chromosome 10q11.2.

Gene Wiki entry for NPY1R (Neuropeptide Y receptor Y1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPY1R gene promoter:
         GR   p53   SREBP-1c   XBP-1   HNF-1A   SREBP-1b   Evi-1   SREBP-1a   HNF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY1R promoter sequence
   Search Chromatin IP Primers for NPY1R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY1R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3-q32   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q31.3-q32

NPY1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY1R gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M164245:  view genomic region     (about GC identifiers)

Start:
164,245,113 bp from pter      End:
164,265,984 bp from pter
Size:
20,872 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NPY1R_HUMAN, P25929 (See protein sequence)
Recommended Name: Neuropeptide Y receptor type 1  
Size: 384 amino acids; 44392 Da
2 PDB 3D structures from and Proteopedia for NPY1R:
2F1U (3D)        2IIL (3D)    
Secondary accessions: B2R6H5

Explore the universe of human proteins at neXtProt for NPY1R: NX_P25929

Explore proteomics data for NPY1R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn11, Asn17
  • Modification sites at PhosphoSitePlus

  • See NPY1R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000900.1  
    ENSEMBL proteins: 
     ENSP00000354652   ENSP00000427284   ENSP00000422963   ENSP00000421618   ENSP00000427564  
     ENSP00000426099   ENSP00000423878  
    Reactome Protein details: P25929

    NPY1R Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPYR: GPCR / Class A : Neuropeptide receptors : Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: Y1 receptor
    Neuropeptide Y receptors

    4 InterPro protein domains:
     IPR000351 NPY1_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry P25929

    ProtoNet protein and cluster: P25929

    2 Blocks protein domains:
    IPB000351 Neuropeptide Y1 receptor signature
    IPB000611 Neuropeptide Y receptor signature


    UniProtKB/Swiss-Prot: NPY1R_HUMAN, P25929
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NPY1R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY1R_HUMAN, P25929
    Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic
    polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY
    (3-36) > PP > NPY free acid

         Genatlas biochemistry entry for NPY1R:
    neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001601peptide YY receptor activity IEA--
    GO:0001602pancreatic polypeptide receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity TAS1317848
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with NPY1R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NPY1R:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Npy1r) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with NPY1R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NPY1R: Npy1rtm1Aka Npy1rtm1.2Ceva Npy1rtm1.1Wpg Npy1rtm1Tped Npy1rtm1Mnak

       genOway: Develop your customized and physiologically relevant rodent model for NPY1R

    miRNA
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    miRTarBase miRNAs that target NPY1R:
    hsa-mir-335-5p (MIRT018353)

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    Selected qRT-PCR Assays for microRNAs that regulate NPY1R (see all 10):
    hsa-miR-549 hsa-miR-3607-3p hsa-miR-3688-3p hsa-miR-218 hsa-miR-374c hsa-miR-369-3p hsa-miR-655 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidNPY1R 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPY1R_HUMAN, P25929: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1317848
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NPY1R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPY1R About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Neuroeffector Junction)
    5Endothelin
    Endothelin


    Find genes that share SuperPaths with NPY1R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NPY1R
        GPCRs, Class A Rhodopsin-like
    Endothelin
    Peptide GPCRs

    2 Reactome Pathways for NPY1R
        Peptide ligand-binding receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for NPY1R
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    1 Kegg Pathway  (Kegg details for NPY1R):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY1R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPY1R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY1R (P259291, 3 ENSP000003546524) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPYP013033, ENSP000002421524I2D: score=2 STRING: ENSP00000242152
    LSM7Q9UK453, ENSP000002526224I2D: score=4 STRING: ENSP00000252622
    PYYP100821, ENSP000003531984EBI-372227,EBI-6655667 STRING: ENSP00000353198
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY7ENSP000002542354STRING: ENSP00000254235
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003151outflow tract morphogenesis IMP19593212
    GO:0006006glucose metabolic process IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1317848
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS1321422

    Find genes that share ontologies with NPY1R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPY1R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    Selected IUPHAR Ligands for NPY1R (Y1 receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]PYY (pig)
    AgonistFull agonist10.216097949
    NPY
    AgonistFull agonist9.716097949
    BIBO3304
    AntagonistAntagonist9.59806339
    [3H]BIBP3226
    AntagonistAntagonist8.7--
    SR120819A
    AntagonistAntagonist8.416097949
    BIBP3226
    AntagonistAntagonist8.1 - 8.216097949 8700207
    [Leu31,Pro34]NPY
    AgonistAgonist7.18590988
    [Ala31,Aib32]NPY (pig)
    AgonistFull agonist612069595
    [125I][Leu31,Pro34]NPY
    AgonistFull agonist6--
    [Pro34]NPY
    AgonistFull agonist6--

    7 Novoseek inferred chemical compound relationships for NPY1R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibp3226 93.3 5 8880067 (2), 7664808 (1), 10422644 (1), 7705422 (1)
    benzimidazole 38.1 1 10201822 (1)
    atp 0 2 9131413 (2)
    nitric oxide 0 1 10721817 (1)
    calcium 0 3 8088364 (1), 9650840 (1), 7705427 (1)
    estrogen 0 4 16585197 (1), 15473135 (1)
    histamine 0 1 16787226 (1)



    Find genes that share compounds with NPY1R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPY1R gene: 
    NM_000909.5  

    Unigene Cluster for NPY1R:

    Neuropeptide Y receptor Y1
    Hs.519057  [show with all ESTs]
    Unigene Representative Sequence: AB209237
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296533(uc003iqm.2 uc011cjj.2) ENST00000509586 ENST00000504391
    ENST00000512819 ENST00000504790 ENST00000515701 ENST00000511901
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      QuantiTect SYBR Green Assays in human, mouse, rat NPY1R
      QuantiFast Probe-based Assays in human, mouse, rat NPY1R

    Additional mRNA sequence: 

    AB209237.1 AK296624.1 AK298282.1 AK312578.1 AY548168.1 BC036657.2 BC071720.1 L07615.3 
    M84755.1 M88461.1 

    2 DOTS entries:

    DT.414335  DT.100749550 

    Selected AceView cDNA sequences (see all 43):

    AA747415 BC036657 AA506769 CA394084 NM_000909 AY548168 T28825 AA437062 
    F03236 AW025037 M88461 AW604803 BX103674 M84755 BC071720 AI279702 
    BX501278 F06965 AU100210 R77734 AU077136 BP380493 AA975392 BX506438 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:        -                           
    SP2:        -                           
    SP3:                                    


    ECgene alternative splicing isoforms for NPY1R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPY1R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGATTT
    NPY1R Expression
    About this image


    NPY1R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Breast (Uncategorized)
     
     Spleen (Hematopoietic System)
    NPY1R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY1R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519057
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY1R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPY1R gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npy1r1 , 5 neuropeptide Y receptor Y11, 5 85.43(n)1
    93.98(a)1
      8 (33.15 cM)5
    181661  NM_010934.41  NP_035064.11 
     666974225 
    chicken
    (Gallus gallus)
    Aves NPY1R1 neuropeptide Y receptor Y1 78.18(n)
    84.03(a)
      428727  NM_001031535.1  NP_001026706.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY1R6
    neuropeptide Y receptor Y1
    81(a)
    1 ↔ 1
    5(126155628-126158151)
    African clawed frog
    (Xenopus laevis)
    Amphibia npy1r-A2 neuropeptide Y receptor Y1, NPY/PYY receptor Y1 77.08(n)    L25416.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npy1r1 neuropeptide Y receptor Y1 60.78(n)
    61.25(a)
      793668  NM_001102391.1  NP_001095861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NPFR13 G-protein coupled receptor protein
    signaling pathway more
    31(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea npr-71 npr-7 43.04(n)
    31.23(a)
      185321  NM_077169.4  NP_509570.3 


    ENSEMBL Gene Tree for NPY1R (if available)
    TreeFam Gene Tree for NPY1R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPY1R gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    9 SIMAP similar genes for NPY1R using alignment to 7 protein entries:     NPY1R_HUMAN (see all proteins):
    NPY6R    NPY4R    PPYR1    PRLHR    GPR83    QRFPR
    NPY2R    NPFFR1    NPFFR2

    Find genes that share paralogs with NPY1R           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NPY1R
    PGOHUM00000235768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPY1R (see all 238)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392782221,2
    C--164244660(+) AATGCC/TCTTTT 1 -- int10--------
    rs1154765041,2
    C,F--164244715(+) TTCTTG/AGTAAA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1475473391,2
    --164244771(+) TCAATA/GAGATT 1 -- int10--------
    rs1481701521,2
    --164244853(+) TATTTG/TCACTG 1 -- int10--------
    rs1825728461,2
    --164244966(+) CAATGA/GTTATA 1 -- int10--------
    rs39677621,2
    C,F,A,H--164244976(-) CATCAA/GTGGTT 1 -- int110Minor allele frequency- G:0.44NA WA EA 372
    rs1506208191,2
    --164245028(+) ATGTTG/TCATTA 1 -- int10--------
    rs40577971,2
    C,F,A,H--164245053(-) CCCAAA/TGCATC 1 -- int124Minor allele frequency- N:0.00NS EA NA WA CSA 1100
    rs780720611,2
    C,F--164245054(+) ATGCTT/CTGGGA 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1868027871,2
    --164245055(+) TGCTTC/TGGGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NPY1R (164245113 - 164265984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NPY1R:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822812CNV Gain20364138

    Human Gene Mutation Database (HGMD): NPY1R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY1R
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY1R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162641    OMIM disorders: --

    4 diseases for NPY1R:    
    About MalaCards
    proliferative vitreoretinopathy    angina pectoris    morbid obesity    obesity


    Find genes that share disorders with NPY1R           About GenesLikeMe

    5 Novoseek inferred disease relationships for NPY1R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 29.5 2 9669502 (1), 9650840 (1)
    nephropathy iga 25.1 2 10976391 (1), 10363627 (1)
    breast cancer 0 2 16585197 (1), 15473135 (1)
    adenocarcinoma 0 2 8880067 (1), 8886416 (1)
    obesity 0 3 7902088 (2), 9222646 (1)

    Genetic Association Database (GAD): NPY1R
    Human Genome Epidemiology (HuGE) Navigator: NPY1R (22 documents)

    Export disorders for NPY1R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPY1R gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with NPY1R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PubMed id 8095935)1, 2, 3, 9 Herzog H.... Shine J. (J. Biol. Chem. 1993)
    2. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PubMed id 19759915)1, 4, 9 Elbers C.C....Onland-Moret N.C. (PLoS ONE 2009)
    3. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PubMed id 19506390)1, 4, 9 Rothenbuhler A....Fradin D. (Horm. Res. 2009)
    4. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PubMed id 17325259)1, 4, 9 Campbell C.D....Hirschhorn J.N. (Diabetes 2007)
    5. Melanocortin-4 receptor gene and physical activity in the QuAcbec Family Study. (PubMed id 15597110)1, 4, 9 Loos R.J....Bouchard C. (Int J Obes (Lond) 2005)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1, 4 Kim H.Y....Kim H. (BMB Rep 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    10. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. (PubMed id 19077438)1, 4 Chung W.K....Tiwari H.K. (Hum. Hered. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4886 HGNC: 7956 AceView: NPY1R Ensembl:ENSG00000164128 euGenes: HUgn4886
    ECgene: NPY1R Kegg: 4886 H-InvDB: NPY1R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPY1R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NPY1R Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPY1R gene:
    Search GeneIP for patents involving NPY1R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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