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Aliases for NPY1R Gene

Aliases for NPY1R Gene

  • Neuropeptide Y Receptor Y1 2 3
  • NPY1-R 3 4
  • NPYR 3 4
  • Neuropeptide Y Receptor Type 1 3
  • NPYY1 4

External Ids for NPY1R Gene

Previous Symbols for NPY1R Gene

  • NPYR

Summaries for NPY1R Gene

Entrez Gene Summary for NPY1R Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

GeneCards Summary for NPY1R Gene

NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Diseases associated with NPY1R include angina pectoris and obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide Y receptor activity and pancreatic polypeptide receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY1R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Tocris Summary for NPY1R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY1R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY1R Gene

Genomics for NPY1R Gene

Genomic Location for NPY1R Gene

Start:
163,323,961 bp from pter
End:
163,344,832 bp from pter
Size:
20,872 bases
Orientation:
Minus strand

Genomic View for NPY1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY1R Gene

Regulatory Elements for NPY1R Gene

Proteins for NPY1R Gene

  • Protein details for NPY1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25929-NPY1R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 1
    Protein Accession:
    P25929
    Secondary Accessions:
    • B2R6H5

    Protein attributes for NPY1R Gene

    Size:
    384 amino acids
    Molecular mass:
    44392 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY1R Gene

neXtProt entry for NPY1R Gene

Proteomics data for NPY1R Gene at MOPED

Post-translational modifications for NPY1R Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn2, Asn11, and Asn17

Other Protein References for NPY1R Gene

No data available for DME Specific Peptides for NPY1R Gene

Domains for NPY1R Gene

Gene Families for NPY1R Gene

HGNC:
  • NPYR :GPCR / Class A : Neuropeptide receptors : Y
IUPHAR :

UniProtKB/Swiss-Prot:

NPY1R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P25929
genes like me logo Genes that share domains with NPY1R: view

Function for NPY1R Gene

Molecular function for NPY1R Gene

GENATLAS Biochemistry: neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Gene Ontology (GO) - Molecular Function for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 1317848
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NPY1R: view
genes like me logo Genes that share phenotypes with NPY1R: view

Animal Models for NPY1R Gene

MGI Knock Outs for NPY1R:

miRNA for NPY1R Gene

miRTarBase miRNAs that target NPY1R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPY1R Gene

Localization for NPY1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPY1R Gene COMPARTMENTS Subcellular localization image for NPY1R gene
Compartment Confidence
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1317848
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY1R: view

Pathways for NPY1R Gene

genes like me logo Genes that share pathways with NPY1R: view

Pathways by source for NPY1R Gene

Gene Ontology (GO) - Biological Process for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0006006 glucose metabolic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 1321422
genes like me logo Genes that share ontologies with NPY1R: view

Compounds for NPY1R Gene

(5) Tocris Compounds for NPY1R Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist [132699-73-1]
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist [159013-54-4]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]

(12) IUPHAR Ligand for NPY1R Gene

Ligand Type Action Affinity Pubmed IDs
[125I]PYY (pig) Agonist Full agonist 10.2
BIBO3304 Antagonist Antagonist 9.5
NPY Agonist Full agonist 9.3
[Leu31,Pro34]PYY (human) Agonist Full agonist 8.8
[3H]BIBP3226 Antagonist Antagonist 8.7
SR120819A Antagonist Antagonist 8.4
[Ala31,Aib32]NPY (pig) Agonist Full agonist 8.2
BIBP3226 Antagonist Antagonist 7.8
[Pro34]PYY (human) Agonist Full agonist 6.3
[Leu31,Pro34]NPY Agonist Full agonist 6.2
[125I][Leu31,Pro34]NPY Agonist Full agonist
[Pro34]NPY Agonist Full agonist

(7) Novoseek inferred chemical compound relationships for NPY1R Gene

Compound -log(P) Hits PubMed IDs
bibp3226 93.3 5
benzimidazole 38.1 1
atp 0 2
nitric oxide 0 1
calcium 0 3
genes like me logo Genes that share compounds with NPY1R: view

Transcripts for NPY1R Gene

Unigene Clusters for NPY1R Gene

Neuropeptide Y receptor Y1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for NPY1R Gene

GeneLoc Exon Structure for
NPY1R
ECgene alternative splicing isoforms for
NPY1R

Expression for NPY1R Gene

mRNA expression in normal human tissues for NPY1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY1R Gene

This gene is overexpressed in Spleen (8.6) and Artery - Tibial (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPY1R Gene

SOURCE GeneReport for Unigene cluster for NPY1R Gene Hs.519057

genes like me logo Genes that share expressions with NPY1R: view

Orthologs for NPY1R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPY1R 36
  • 99.56 (n)
  • 100 (a)
NPY1R 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPY1R 36
  • 89.82 (n)
  • 95.3 (a)
NPY1R 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY1R 36
  • 91.97 (n)
  • 96.34 (a)
NPY1R 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npy1r 36
  • 85.43 (n)
  • 93.98 (a)
Npy1r 16
Npy1r 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7323 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY1R 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npy1r 36
  • 85.43 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves NPY1R 36
  • 78.18 (n)
  • 84.03 (a)
NPY1R 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY1R 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia npy1r-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia npy1r 36
  • 73.99 (n)
  • 79.4 (a)
zebrafish
(Danio rerio)
Actinopterygii npy1r 36
  • 60.78 (n)
  • 61.25 (a)
npy1r 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NPFR1 37
  • 22 (a)
OneToMany
CG10626 38
  • 31 (a)
NPFR1 38
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea npr-11 37
  • 25 (a)
ManyToMany
npr-12 37
  • 24 (a)
ManyToMany
npr-7 36
  • 43.04 (n)
  • 31.23 (a)
Species with no ortholog for NPY1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY1R Gene

ENSEMBL:
Gene Tree for NPY1R (if available)
TreeFam:
Gene Tree for NPY1R (if available)

Paralogs for NPY1R Gene

Selected SIMAP similar genes for NPY1R Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for NPY1R Gene

genes like me logo Genes that share paralogs with NPY1R: view

Variants for NPY1R Gene

Sequence variations from dbSNP and Humsavar for NPY1R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs5577 -- 163,326,591(-) TCCAT(G/T)TGTCT utr-variant-5-prime
rs5578 - 163,325,337(-) TAAAA(A/C)AATCA reference, missense
rs9151 -- 163,324,154(+) AACTA(C/T)TCAGT utr-variant-3-prime
rs9764 -- 163,324,253(+) GTGTA(C/T)TTTTC utr-variant-3-prime
rs3967762 -- 163,323,824(-) CATCA(A/G)TGGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NPY1R Gene

Variant ID Type Subtype PubMed ID
nsv822812 CNV Gain 20364138

Relevant External Links for NPY1R Gene

HapMap Linkage Disequilibrium report
NPY1R
Human Gene Mutation Database (HGMD)
NPY1R

Disorders for NPY1R Gene

(5) Novoseek inferred disease relationships for NPY1R Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 29.5 2
nephropathy iga 25.1 2
breast cancer 0 2
adenocarcinoma 0 2
obesity 0 3

Relevant External Links for NPY1R

Genetic Association Database (GAD)
NPY1R
Human Genome Epidemiology (HuGE) Navigator
NPY1R
genes like me logo Genes that share disorders with NPY1R: view

No data available for UniProtKB/Swiss-Prot for NPY1R Gene

Publications for NPY1R Gene

  1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PMID: 8095935) Herzog H. … Shine J. (J. Biol. Chem. 1993) 2 3 4 23
  2. Melanocortin-4 receptor gene and physical activity in the QuAcbec Family Study. (PMID: 15597110) Loos R.J. … Bouchard C. (Int J Obes (Lond) 2005) 3 23 49
  3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23 49
  4. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PMID: 19506390) Rothenbuhler A. … Fradin D. (Horm. Res. 2009) 3 23 49
  5. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PMID: 19759915) Elbers C.C. … Onland-Moret N.C. (PLoS ONE 2009) 3 23 49

Products for NPY1R Gene

Sources for NPY1R Gene

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