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Aliases for NPY1R Gene

Aliases for NPY1R Gene

  • Neuropeptide Y Receptor Y1 2 3
  • NPY1-R 3 4
  • NPYR 3 4
  • NPYY1 4

External Ids for NPY1R Gene

Previous HGNC Symbols for NPY1R Gene

  • NPYR

Previous GeneCards Identifiers for NPY1R Gene

  • GC04M165094
  • GC04M164673
  • GC04M164822
  • GC04M164602
  • GC04M164464
  • GC04M164245
  • GC04M159999

Summaries for NPY1R Gene

Entrez Gene Summary for NPY1R Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

GeneCards Summary for NPY1R Gene

NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and peptide YY receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY1R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Tocris Summary for NPY1R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY1R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY1R Gene

Genomics for NPY1R Gene

Regulatory Elements for NPY1R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY1R Gene

Chromosome:
4
Start:
163,323,961 bp from pter
End:
163,344,832 bp from pter
Size:
20,872 bases
Orientation:
Minus strand

Genomic View for NPY1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY1R Gene

Proteins for NPY1R Gene

  • Protein details for NPY1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25929-NPY1R_HUMAN
    Recommended name:
    Neuropeptide Y receptor type 1
    Protein Accession:
    P25929
    Secondary Accessions:
    • B2R6H5

    Protein attributes for NPY1R Gene

    Size:
    384 amino acids
    Molecular mass:
    44392 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY1R Gene

neXtProt entry for NPY1R Gene

Proteomics data for NPY1R Gene at MOPED

Post-translational modifications for NPY1R Gene

  • Glycosylation at Asn 2, Asn 11, and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY1R Gene

Antibody Products

No data available for DME Specific Peptides for NPY1R Gene

Domains & Families for NPY1R Gene

Gene Families for NPY1R Gene

Suggested Antigen Peptide Sequences for NPY1R Gene

Graphical View of Domain Structure for InterPro Entry

P25929

UniProtKB/Swiss-Prot:

NPY1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY1R: view

Function for NPY1R Gene

Molecular function for NPY1R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Gene Ontology (GO) - Molecular Function for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IBA --
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 1317848
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NPY1R: view
genes like me logo Genes that share phenotypes with NPY1R: view

Animal Models for NPY1R Gene

MGI Knock Outs for NPY1R:

Animal Model Products

miRNA for NPY1R Gene

miRTarBase miRNAs that target NPY1R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPY1R Gene

Localization for NPY1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPY1R Gene COMPARTMENTS Subcellular localization image for NPY1R gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1317848
GO:0008021 synaptic vesicle IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY1R: view

Pathways & Interactions for NPY1R Gene

genes like me logo Genes that share pathways with NPY1R: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for NPY1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0006006 glucose metabolic process IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848
genes like me logo Genes that share ontologies with NPY1R: view

Drugs & Compounds for NPY1R Gene

(19) Drugs for NPY1R Gene - From: NovoSeek, IUPHAR, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 540
Benzimidazole Experimental Pharma 4
AC162352 Investigational Pharma Target 0
BIBP3226 Pharma Antagonist 0
[<sup>125</sup>I][Leu<sup>31</sup>,Pro<sup>34</sup>]NPY Pharma Full agonist, Agonist 0

(5) Additional Compounds for NPY1R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (porcine)
125580-28-1
BIBP 3226 trifluoroacetate
1068148-47-9
GR 231118
158859-98-4
Neuropeptide Y (human, rat)
90880-35-6
Pancreatic Polypeptide (human)
75976-10-2
genes like me logo Genes that share compounds with NPY1R: view

Transcripts for NPY1R Gene

Unigene Clusters for NPY1R Gene

Neuropeptide Y receptor Y1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for NPY1R Gene

GeneLoc Exon Structure for
NPY1R
ECgene alternative splicing isoforms for
NPY1R

Expression for NPY1R Gene

mRNA expression in normal human tissues for NPY1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY1R Gene

This gene is overexpressed in Spleen (x8.6) and Artery - Tibial (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY1R Gene



SOURCE GeneReport for Unigene cluster for NPY1R Gene Hs.519057

genes like me logo Genes that share expression patterns with NPY1R: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NPY1R Gene

Orthologs for NPY1R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY1R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPY1R 35
  • 89.82 (n)
  • 95.3 (a)
NPY1R 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPY1R 35
  • 91.97 (n)
  • 96.34 (a)
NPY1R 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npy1r 35
  • 85.43 (n)
  • 93.98 (a)
Npy1r 16
Npy1r 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPY1R 35
  • 99.56 (n)
  • 100 (a)
NPY1R 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npy1r 35
  • 85.43 (n)
  • 93.46 (a)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7323 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPY1R 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPY1R 35
  • 78.18 (n)
  • 84.03 (a)
NPY1R 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPY1R 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npy1r 35
  • 73.99 (n)
  • 79.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia npy1r-A 35
zebrafish
(Danio rerio)
Actinopterygii npy1r 35
  • 60.78 (n)
  • 61.25 (a)
npy1r 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 31 (a)
NPFR1 37
  • 31 (a)
NPFR1 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-7 35
  • 43.04 (n)
  • 31.23 (a)
npr-11 36
  • 25 (a)
ManyToMany
npr-12 36
  • 24 (a)
ManyToMany
Species with no ortholog for NPY1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY1R Gene

ENSEMBL:
Gene Tree for NPY1R (if available)
TreeFam:
Gene Tree for NPY1R (if available)

Paralogs for NPY1R Gene

(9) SIMAP similar genes for NPY1R Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for NPY1R Gene

genes like me logo Genes that share paralogs with NPY1R: view

Variants for NPY1R Gene

Sequence variations from dbSNP and Humsavar for NPY1R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_014681 -

Structural Variations from Database of Genomic Variants (DGV) for NPY1R Gene

Variant ID Type Subtype PubMed ID
nsv822812 CNV Gain 20364138

Variation tolerance for NPY1R Gene

Residual Variation Intolerance Score: 35.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY1R Gene

HapMap Linkage Disequilibrium report
NPY1R
Human Gene Mutation Database (HGMD)
NPY1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY1R Gene

Disorders for NPY1R Gene

Relevant External Links for NPY1R

Genetic Association Database (GAD)
NPY1R
Human Genome Epidemiology (HuGE) Navigator
NPY1R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY1R
genes like me logo Genes that share disorders with NPY1R: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPY1R Gene

Publications for NPY1R Gene

  1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PMID: 8095935) Herzog H. … Shine J. (J. Biol. Chem. 1993) 2 23 67
  2. Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease. (PMID: 20142765) Lin J. … Lei Z. (J. Neuropathol. Exp. Neurol. 2010) 23 67
  3. Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists. (PMID: 19596193) Cho K. … Sato N. (Bioorg. Med. Chem. Lett. 2009) 23 67
  4. Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity. (PMID: 19487123) Kameda M. … Sato N. (Bioorg. Med. Chem. Lett. 2009) 23 67
  5. 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor. (PMID: 19916528) Gao J. … Hamann M.T. (J. Nat. Prod. 2009) 23 67

Products for NPY1R Gene

Sources for NPY1R Gene

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