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Aliases for NPY1R Gene

Aliases for NPY1R Gene

  • Neuropeptide Y Receptor Y1 2 3
  • NPY1-R 3 4
  • NPYR 3 4
  • Neuropeptide Y Receptor Type 1 3
  • NPYY1 4

External Ids for NPY1R Gene

Previous HGNC Symbols for NPY1R Gene

  • NPYR

Previous GeneCards Identifiers for NPY1R Gene

  • GC04M165094
  • GC04M164673
  • GC04M164822
  • GC04M164602
  • GC04M164464
  • GC04M164245
  • GC04M159999

Summaries for NPY1R Gene

Entrez Gene Summary for NPY1R Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

GeneCards Summary for NPY1R Gene

NPY1R (Neuropeptide Y Receptor Y1) is a Protein Coding gene. Diseases associated with NPY1R include angina pectoris and morbid obesity. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide Y receptor activity and pancreatic polypeptide receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPY1R Gene

  • Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Tocris Summary for NPY1R Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

Gene Wiki entry for NPY1R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY1R Gene

Genomics for NPY1R Gene

Regulatory Elements for NPY1R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY1R Gene

163,323,961 bp from pter
163,344,832 bp from pter
20,872 bases
Minus strand

Genomic View for NPY1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY1R Gene

Proteins for NPY1R Gene

  • Protein details for NPY1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide Y receptor type 1
    Protein Accession:
    Secondary Accessions:
    • B2R6H5

    Protein attributes for NPY1R Gene

    384 amino acids
    Molecular mass:
    44392 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY1R Gene

neXtProt entry for NPY1R Gene

Proteomics data for NPY1R Gene at MOPED

Post-translational modifications for NPY1R Gene

  • Glycosylation at Asn2, Asn11, and Asn17
  • Modification sites at PhosphoSitePlus

Other Protein References for NPY1R Gene

Antibody Products

No data available for DME Specific Peptides for NPY1R Gene

Domains for NPY1R Gene

Gene Families for NPY1R Gene

Suggested Antigen Peptide Sequences for NPY1R Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPY1R: view

Function for NPY1R Gene

Molecular function for NPY1R Gene

GENATLAS Biochemistry:
neuropeptide Y receptor Y1,overlapping NPY5R,in opposite orientation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid

Gene Ontology (GO) - Molecular Function for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001601 peptide YY receptor activity IEA --
GO:0001602 pancreatic polypeptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004983 neuropeptide Y receptor activity TAS 1317848
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NPY1R: view
genes like me logo Genes that share phenotypes with NPY1R: view

Animal Models for NPY1R Gene

MGI Knock Outs for NPY1R:

Animal Model Products

miRNA for NPY1R Gene

miRTarBase miRNAs that target NPY1R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPY1R Gene

Localization for NPY1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPY1R Gene COMPARTMENTS Subcellular localization image for NPY1R gene
Compartment Confidence
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1317848
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPY1R: view

Pathways for NPY1R Gene

genes like me logo Genes that share pathways with NPY1R: view

Pathways by source for NPY1R Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NPY1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003151 outflow tract morphogenesis IMP 19593212
GO:0006006 glucose metabolic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 1321422
genes like me logo Genes that share ontologies with NPY1R: view

Drugs for NPY1R Gene

(1) Drugbank Compounds for NPY1R Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • PYY 3-36
Target investigational

(5) Tocris Compounds for NPY1R Gene

Compound Action Cas Number
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist [191868-14-1]
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
LU AA33810 Potent NPY Y5 receptor antagonist [304008-29-5]
Neuropeptide Y (human, rat) Influences feeding and sexual behavior [90880-35-6]
SF 11 NPY Y2 receptor antagonist [443292-81-7]

(12) IUPHAR Ligand for NPY1R Gene

Ligand Type Action Affinity Pubmed IDs
[125I]PYY (pig) Agonist Full agonist 10.2
BIBO3304 Antagonist Antagonist 9.5
NPY Agonist Full agonist 9.3
[Leu31,Pro34]PYY (human) Agonist Full agonist 8.8
[3H]BIBP3226 Antagonist Antagonist 8.7
SR120819A Antagonist Antagonist 8.4
[Ala31,Aib32]NPY (pig) Agonist Full agonist 8.2
BIBP3226 Antagonist Antagonist 7.8
[Pro34]PYY (human) Agonist Full agonist 6.3
[Leu31,Pro34]NPY Agonist Full agonist 6.2
[125I][Leu31,Pro34]NPY Agonist Full agonist
[Pro34]NPY Agonist Full agonist

(7) Novoseek inferred chemical compound relationships for NPY1R Gene

Compound -log(P) Hits PubMed IDs
bibp3226 93.3 5
benzimidazole 38.1 1
calcium 0 3
estrogen 0 2
nitric oxide 0 1
genes like me logo Genes that share compounds with NPY1R: view

Transcripts for NPY1R Gene

Unigene Clusters for NPY1R Gene

Neuropeptide Y receptor Y1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPY1R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for NPY1R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY1R Gene

mRNA expression in normal human tissues for NPY1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY1R Gene

This gene is overexpressed in Spleen (8.6) and Artery - Tibial (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPY1R Gene

SOURCE GeneReport for Unigene cluster for NPY1R Gene Hs.519057

genes like me logo Genes that share expressions with NPY1R: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for NPY1R Gene

Orthologs for NPY1R Gene

This gene was present in the common ancestor of animals.

Orthologs for NPY1R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPY1R 35
  • 89.82 (n)
  • 95.3 (a)
NPY1R 36
  • 95 (a)
(Canis familiaris)
Mammalia NPY1R 35
  • 91.97 (n)
  • 96.34 (a)
NPY1R 36
  • 96 (a)
(Mus musculus)
Mammalia Npy1r 35
  • 85.43 (n)
  • 93.98 (a)
Npy1r 16
Npy1r 36
  • 94 (a)
(Pan troglodytes)
Mammalia NPY1R 35
  • 99.56 (n)
  • 100 (a)
NPY1R 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Npy1r 35
  • 85.43 (n)
  • 93.46 (a)
(Monodelphis domestica)
Mammalia mdo-mir-7323 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia NPY1R 36
  • 48 (a)
(Gallus gallus)
Aves NPY1R 35
  • 78.18 (n)
  • 84.03 (a)
NPY1R 36
  • 84 (a)
(Anolis carolinensis)
Reptilia NPY1R 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy1r 35
  • 73.99 (n)
  • 79.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia npy1r-A 35
(Danio rerio)
Actinopterygii npy1r 35
  • 60.78 (n)
  • 61.25 (a)
npy1r 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 31 (a)
NPFR1 37
  • 31 (a)
NPFR1 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea npr-7 35
  • 43.04 (n)
  • 31.23 (a)
npr-11 36
  • 25 (a)
npr-12 36
  • 24 (a)
Species with no ortholog for NPY1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPY1R Gene

Gene Tree for NPY1R (if available)
Gene Tree for NPY1R (if available)

Paralogs for NPY1R Gene

(9) SIMAP similar genes for NPY1R Gene using alignment to 7 proteins: Pseudogenes for NPY1R Gene

genes like me logo Genes that share paralogs with NPY1R: view

Variants for NPY1R Gene

Sequence variations from dbSNP and Humsavar for NPY1R Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs141783083 -- 163,336,854(+) TACTC(A/G)GGAGG intron-variant
rs141709956 -- 163,327,241(+) ACTAC(A/G)GTGAA intron-variant
rs141320999 -- 163,341,876(+) CCCCT(-/G)GGAAA intron-variant
rs141286190 -- 163,339,184(+) CATAC(A/G)AAACC intron-variant
rs141250862 -- 163,332,283(+) CGTCG(G/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY1R Gene

Variant ID Type Subtype PubMed ID
nsv822812 CNV Gain 20364138

Relevant External Links for NPY1R Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY1R Gene

Disorders for NPY1R Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NPY1R Gene in MalaCards »

(3) Diseases for NPY1R Gene

(5) Novoseek inferred disease relationships for NPY1R Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 29.5 2
nephropathy iga 25.1 2
breast cancer 0 2
adenocarcinoma 0 2
obesity 0 3

Relevant External Links for NPY1R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPY1R: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NPY1R Gene

Publications for NPY1R Gene

  1. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. (PMID: 8095935) Herzog H. … Shine J. (J. Biol. Chem. 1993) 2 3 4 23
  2. Melanocortin-4 receptor gene and physical activity in the QuAcbec Family Study. (PMID: 15597110) Loos R.J. … Bouchard C. (Int J Obes (Lond) 2005) 3 23 48
  3. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. (PMID: 17325259) Campbell C.D. … Hirschhorn J.N. (Diabetes 2007) 3 23 48
  4. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. (PMID: 19506390) Rothenbuhler A. … Fradin D. (Horm. Res. 2009) 3 23 48
  5. Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans. (PMID: 19759915) Elbers C.C. … Onland-Moret N.C. (PLoS ONE 2009) 3 23 48

Products for NPY1R Gene

Sources for NPY1R Gene

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