Aliases for NPY Gene
External Ids for NPY Gene
- HGNC: 7955
- Entrez Gene: 4852
- Ensembl: ENSG00000122585
- OMIM: 162640
- UniProtKB: P01303
Previous GeneCards Identifiers for NPY Gene
- GC07P023966
- GC07P024032
- GC07P024066
- GC07P024097
Summaries for NPY Gene
-
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
GeneCards Summary for NPY Gene
NPY (Neuropeptide Y) is a Protein Coding gene. Diseases associated with NPY include Autonomic Neuropathy and Breath-Holding Spells. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is PYY.
UniProtKB/Swiss-Prot for NPY Gene
-
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
-
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.
Additional gene information for NPY Gene
- Monarch Initiative
- Search for NPY at DataMed
- Search for NPY at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY Gene
Genomics for NPY Gene
GeneHancer (GH) Regulatory Elements for NPY Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH07I024284 | Promoter | 0.6 | EPDnew | 550.8 | +0.0 | 8 | 0.1 | EZH2 | NPY GC07P024499 | |
GH07I023529 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 4.9 | -752.8 | -752795 | 3.2 | FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 ZNF143 | TRA2A GC07P023532 PIR50375 NPY GC07M023491 ENSG00000200847 | |
GH07I024290 | Enhancer | 1 | Ensembl ENCODE | 4.8 | +6.2 | 6238 | 0.4 | CTCF PKNOX1 MAX EBF1 BATF ZIC2 ZNF2 IRF4 RAD21 RFX5 | NPY GC07P024499 | |
GH07I023814 | Enhancer | 0.2 | FANTOM5 | 12.3 | -470.0 | -470005 | 0 | NPY TPT1P7 GC07M023895 STK31 | ||
GH07I024341 | Enhancer | 0.3 | FANTOM5 | 7.3 | +57.8 | 57834 | 0.4 | USF1 | NPY GC07P024499 |
Regulatory Element Products
Genomic Locations for NPY Gene
- chr7:24,284,163-24,291,865
- (GRCh38/hg38)
- Size:
- 7,703 bases
- Orientation:
- Plus strand
- chr7:24,323,782-24,331,484
- (GRCh37/hg19)
Genomic View for NPY Gene
- Cytogenetic band:
-
- 7p15.3 by Ensembl
- 7p15.3 by Entrez Gene
- 7p15.3 by HGNC


RefSeq DNA sequence for NPY Gene
Proteins for NPY Gene
-
Protein details for NPY Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01303-NPY_HUMAN
- Recommended name:
- Pro-neuropeptide Y
- Protein Accession:
- P01303
Protein attributes for NPY Gene
- Size:
- 97 amino acids
- Molecular mass:
- 10851 Da
- Quaternary structure:
- No Data Available
Protein Expression for NPY Gene
Post-translational modifications for NPY Gene
- The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Other Protein References for NPY Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
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-
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No data available for DME Specific Peptides for NPY Gene
Domains & Families for NPY Gene
Gene Families for NPY Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for NPY Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NPY Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01303- Family:
-
- Belongs to the NPY family.
Function for NPY Gene
Molecular function for NPY Gene
- GENATLAS Biochemistry:
- neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
- UniProtKB/Swiss-Prot Function:
- NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Phenotypes From GWAS Catalog for NPY Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001664 | G-protein coupled receptor binding | IBA | -- |
GO:0004930 | G-protein coupled receptor activity | TAS | 1321422 |
GO:0005102 | receptor binding | TAS | 8132547 |
GO:0005179 | hormone activity | IEA | -- |
GO:0005184 | neuropeptide hormone activity | TAS | 2427515 |
Phenotypes for NPY Gene
- MGI mutant phenotypes for NPY:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for NPY:
Animal Model Products
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY Gene
Localization for NPY Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPY Gene
- Secreted.
- Golgi apparatus (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | ISS | -- |
GO:0005623 | cell | TAS | 2444979 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for NPY Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Adipocytokine signaling pathway | ||
4 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
5 | cAMP signaling pathway |
Pathways by source for NPY Gene
1 Cell Signaling Technology pathway for NPY Gene
1 BioSystems pathway for NPY Gene
7 Reactome pathways for NPY Gene
1 PharmGKB pathway for NPY Gene
4 KEGG pathways for NPY Gene
Interacting Proteins for NPY Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006816 | calcium ion transport | TAS | 8132547 |
GO:0006928 | movement of cell or subcellular component | TAS | 10488139 |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | 8132547 |
GO:0007218 | neuropeptide signaling pathway | IBA | -- |
Drugs & Compounds for NPY Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Neuropeptide Y (human, rat) |
|
90880-35-6 |
|
|
(5) Tocris Compounds for NPY Gene
Compound | Action | Cas Number |
---|---|---|
[Leu31,Pro34]-Neuropeptide Y (porcine) | NPY Y1 receptor agonist | 125580-28-1 |
BIBP 3226 trifluoroacetate | Mixed NPY Y1 and NPFF receptor antagonist | |
GR 231118 | Potent NPY Y1 antagonist/NPY Y4 agonist. Binds to NPFF receptors | 158859-98-4 |
Neuropeptide Y (human, rat) | Influences feeding and sexual behavior | 90880-35-6 |
Pancreatic Polypeptide (human) | NPY Y4 agonist; involved in gastrointestinal tract function | 75976-10-2 |
(2) ApexBio Compounds for NPY Gene
Compound | Action | Cas Number |
---|---|---|
[Leu31,Pro34]-Neuropeptide Y (porcine) | 125580-28-1 | |
Neuropeptide Y 13-36 (porcine) | 113662-54-7 |
Transcripts for NPY Gene
mRNA/cDNA for NPY Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPY
- GenScript: Design CRISPR guide RNA sequences for NPY
miRNA Products
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- genomics-online: shRNA clones - Search results for 122 available PpNPY gene related products
- Overview of 122 available PpNPY gene related products
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Recommended
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NPY
- genomics-online: cdna clones - Search results for 122 available NPY1R gene related products
- Overview of 122 available NPY1R gene related products
-
Recommended
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- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
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- pPM-N-D-C-His
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- pPM-C-HA
- pPM-C-His
- pGFP-C-shLenti
- pGFP-V-RS
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- pPB-His-MBP
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- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL5
- pCMV6-Entry
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- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL5
- pCMV6-Entry
- orf clones - Search results for 122 available PpNPY gene related products
- Overview of 122 available PpNPY gene related products
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Recommended
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- Applied Biological Materials Clones for NPY
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | - | - | |||||||||||||||
SP3: |
Expression for NPY Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Neurons
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Ganglion Cell Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Motor neuron progenitor cells(Rossi SL et. al. 2010)
-
Kidney (Urinary System)
- Comma-shaped Body Cells Comma-shaped Body
- Renal Vesicle
- Comma-shaped Body
- Metanephros
-
Eye (Sensory Organs)
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Cholinergic Amacrine Cells Ganglion Cell Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Brain (Nervous System)
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Intermediate Mesoderm (Gastrulation Derivatives)
- NULL (Uncategorized)
- Motor Neurons (Nervous System)
- Spinal Cord (Nervous System)
-
Prostate (Endocrine System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for NPY Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY Gene
NURSA nuclear receptor signaling pathways regulating expression of NPY Gene:
NPYSOURCE GeneReport for Unigene cluster for NPY Gene:
Hs.1832mRNA Expression by UniProt/SwissProt for NPY Gene:
P01303-NPY_HUMANEvidence on tissue expression from TISSUES for NPY Gene
- Nervous system(4.8)
- Liver(4.3)
- Adrenal gland(3.5)
- Blood(2.7)
- Intestine(2.7)
- Muscle(2.6)
- Pancreas(2.6)
- Heart(2.3)
- Kidney(2.2)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs for NPY
-
OriGene qPCR primer pairs and template standards for NPY
- genomics-online: primer clones - Search results for 122 available NPY gene related products
- Overview of 122 available NPY gene related products
-
Recommended
- pPM-C-HA
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- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pRS
- pPM-N-D-C-His
- pPM-N-D-C-HA
- pPM-C-HA
- pPM-C-His
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pPB-N-His
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL5
- pCMV6-Entry
- pRS
- pPM-N-D-C-His
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- pPM-C-HA
- pPM-C-His
- pGFP-C-shLenti
- pGFP-V-RS
- pPM-C-His
- pGFP-C-shLenti
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pPB-N-His
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-XL5
- pCMV6-Entry
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY Gene
Orthologs for NPY Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NPY 34 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NPY 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | NPY 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Npy 33 |
|
||
mouse (Mus musculus) |
Mammalia | Npy 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | NPY 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | NPY 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NPY 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | NPY 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | npy 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | NPY 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | npy 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12071 33 |
|
- Species where no ortholog for NPY was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NPY Gene
Variants for NPY Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16139 | benign, NEUROPEPTIDE Y POLYMORPHISM | 24,285,260(+) | T/A/C | coding_sequence_variant, missense_variant | |
rs1000220116 | -- | 24,287,641(+) | T/C | intron_variant | |
rs1000322339 | -- | 24,282,226(+) | T/G | upstream_transcript_variant | |
rs1000676839 | -- | 24,287,967(+) | T/C | intron_variant | |
rs1000941389 | -- | 24,286,759(+) | A/C | intron_variant |
Additional Variant Information for NPY Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY Gene
Disorders for NPY Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
autonomic neuropathy |
|
|
breath-holding spells |
|
|
adjustment disorder |
|
|
eating disorder |
|
|
temporal lobe epilepsy |
|
Additional Disease Information for NPY
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NPY Gene
Publications for NPY Gene
- PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. (PMID: 19264362) Sjöholm LK … Lavebratt C (Journal of affective disorders 2009) 3 22 44 58
- Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. (PMID: 19566775) Okahisa Y … Kuroda S (Psychiatry and clinical neurosciences 2009) 3 22 44 58
- Genetic variation may influence obesity only under conditions of diet: analysis of three candidate genes. (PMID: 18815063) Aberle J … Beil FU (Molecular genetics and metabolism 2008) 3 22 44 58
- Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. (PMID: 18715275) Nishimura FT … Saijoh K (Alcoholism, clinical and experimental research 2008) 3 22 44 58
- Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (PMID: 18828811) Wetherill L … Foroud T (Alcoholism, clinical and experimental research 2008) 3 22 44 58
Products for NPY Gene
- R&D Systems Antibodies for NPY (Neuropeptide Y/NPY)
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- Mammalian expression: PiggyBac
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- Addgene plasmids for NPY
- antibodies-online: Search results for 170 available NPY1R Antibodies ranked by validation data
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- orf clones - Search results for 122 available NPY1R gene related products
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- genomics-online: gRNA clones - Search results for 122 available NPY1R gene related products
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- genomics-online: primer clones - Search results for 122 available NPY1R gene related products
- Overview of 122 available NPY1R gene related products
- Recommended
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- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
- genomics-online: shRNA clones - Search results for 122 available NPY1R gene related products
- Overview of 122 available NPY1R gene related products
- Recommended
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
- pCMV6-Entry
- pCMV6-XL5
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pPB-N-His
- pPB-His-GST
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pGFP-C-shLenti
- pPM-C-His
- pPM-C-HA
- pPM-N-D-C-HA
- pPM-N-D-C-His
- pRS
Sources for NPY Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew