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NPY Gene(Protein Coding)

Neuropeptide Y

GCID:
GC07P024290
GIFtS:
66
Genes Participants
UDN Logo

Aliases for NPY Gene

Aliases for NPY Gene

  • Neuropeptide Y 2 3 5
  • Prepro-Neuropeptide Y 2 3
  • Pro-Neuropeptide Y 3
  • PYY4 3

External Ids for NPY Gene

Previous GeneCards Identifiers for NPY Gene

  • GC07P023966
  • GC07P024032
  • GC07P024066
  • GC07P024097

Summaries for NPY Gene

Entrez Gene Summary for NPY Gene

  • This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for NPY Gene

NPY (Neuropeptide Y) is a Protein Coding gene. Diseases associated with NPY include Autonomic Neuropathy and Adjustment Disorder. Among its related pathways are Peptide ligand-binding receptors and Regulation of lipolysis in adipocytes. GO annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is PYY.

UniProtKB/Swiss-Prot for NPY Gene

  • NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Tocris Summary for NPY Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY Gene

Genomics for NPY Gene

Products:

  1. Regulatory Element

Regulatory Elements for NPY Gene

Enhancers for NPY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G023529 1.1 ENCODE 4.9 -752.8 -752796 3.2 HDGF FOXA2 PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 TRA2A NPY PIR50375 ENSG00000200847 GC07M023491
GH07G024290 1.1 Ensembl ENCODE 4.8 +6.2 6238 0.4 CTCF PKNOX1 WRNIP1 MAX EBF1 ZIC2 ZNF2 RAD21 RFX5 ZFHX2 NPY GC07P024499
GH07G024171 0.4 ENCODE 10.7 -112.0 -112032 0.8 NFE2 NPY RNA5SP228 ENSG00000228944
GH07G023814 0.3 FANTOM5 12.3 -470.0 -470005 0.0 NPY TPT1P7 GC07M023895
GH07G024341 0.5 FANTOM5 7.3 +57.8 57834 0.4 SMC3 RAD21 NPY GC07P024499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPY on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NPY gene promoter:

Genomic Location for NPY Gene

Chromosome:
7
Start:
24,284,163 bp from pter
End:
24,291,865 bp from pter
Size:
7,703 bases
Orientation:
Plus strand

Genomic View for NPY Gene

Genes around NPY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPY Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NPY Gene

Proteins for NPY Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NPY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01303-NPY_HUMAN
    Recommended name:
    Pro-neuropeptide Y
    Protein Accession:
    P01303

    Protein attributes for NPY Gene

    Size:
    97 amino acids
    Molecular mass:
    10851 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY Gene

neXtProt entry for NPY Gene

Protein Expression for NPY Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NPY Gene

  • The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NPY (Neuropeptide Y/NPY)
  • Cell Signaling Technology (CST) Antibodies for NPY (NPY)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NPY

No data available for DME Specific Peptides for NPY Gene

Domains & Families for NPY Gene

Gene Families for NPY Gene

HGNC:

Protein Domains for NPY Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NPY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01303

UniProtKB/Swiss-Prot:

NPY_HUMAN :
  • Belongs to the NPY family.
Family:
  • Belongs to the NPY family.
genes like me logo Genes that share domains with NPY: view

Function for NPY Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NPY Gene

GENATLAS Biochemistry:
neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
UniProtKB/Swiss-Prot Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Gene Ontology (GO) - Molecular Function for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0004930 G-protein coupled receptor activity TAS 1321422
GO:0005102 receptor binding TAS 8132547
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity TAS 2427515
genes like me logo Genes that share ontologies with NPY: view
genes like me logo Genes that share phenotypes with NPY: view

Animal Models for NPY Gene

MGI Knock Outs for NPY:
  • Npy tm1(rtTA,tetO-cre/EGFP)Snby
  • Npy tm1Rpa

Animal Model Products

miRNA for NPY Gene

miRTarBase miRNAs that target NPY

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NPY

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPY Gene

Localization for NPY Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPY gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
cytosol 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS,IBA --
GO:0005623 cell TAS 2444979
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with NPY: view

Pathways & Interactions for NPY Gene

genes like me logo Genes that share pathways with NPY: view

Pathways by source for NPY Gene

1 Cell Signaling Technology pathway for NPY Gene
1 BioSystems pathway for NPY Gene
1 PharmGKB pathway for NPY Gene

SIGNOR curated interactions for NPY Gene

Activates:

Gene Ontology (GO) - Biological Process for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport TAS 8132547
GO:0006928 movement of cell or subcellular component TAS 10488139
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8132547
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission TAS 10557353
genes like me logo Genes that share ontologies with NPY: view

Drugs & Compounds for NPY Gene

Products:

  1. Drug

(97) Drugs for NPY Gene - From: DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Aminoisobutyric Acid Experimental Pharma Target 0
L-Tyrosinamide Experimental Pharma Target 0
[Leu31,Pro34]-Neuropeptide Y (porcine) Pharma 0
Neuropeptide Y 13-36 (porcine) Pharma 0
[Leu31,Pro34]-Neuropeptide Y (human, rat) Pharma NPY Y1 receptor agonist 0

(47) Additional Compounds for NPY Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuropeptide Y (human, rat)
90880-35-6

(5) Tocris Compounds for NPY Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist 132699-73-1
BIBO 3304 trifluoroacetate Highly selective NPY Y1 receptor antagonist 191868-14-1
BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist 246146-55-4
CGP 71683 hydrochloride Highly selective and potent non-peptide NPY Y5 receptor antagonist 192322-50-2
Neuropeptide Y (human, rat) Influences feeding and sexual behavior 90880-35-6

(2) ApexBio Compounds for NPY Gene

Compound Action Cas Number
[Leu31,Pro34]-Neuropeptide Y (porcine) 125580-28-1
Neuropeptide Y 13-36 (porcine) 113662-54-7
genes like me logo Genes that share compounds with NPY: view

Transcripts for NPY Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NPY Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPY Gene

Neuropeptide Y:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NPY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3:

Relevant External Links for NPY Gene

GeneLoc Exon Structure for
NPY
ECgene alternative splicing isoforms for
NPY

Expression for NPY Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPY Gene

mRNA expression in normal human tissues for NPY Gene
mRNA expression by BioGPS for NPY GenemRNA expression by GTEx for NPY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.2), Prostate (x8.4), Brain - Caudate (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for NPY Gene

This gene is overexpressed in Cerebrospinal fluid (37.4), Seminal vesicle (17.9), and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY Gene



NURSA nuclear receptor signaling pathways regulating expression of NPY Gene:

NPY

SOURCE GeneReport for Unigene cluster for NPY Gene:

Hs.1832

mRNA Expression by UniProt/SwissProt for NPY Gene:

P01303-NPY_HUMAN
Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Evidence on tissue expression from TISSUES for NPY Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Adrenal gland(3.5)
  • Blood(2.7)
  • Intestine(2.7)
  • Muscle(2.6)
  • Pancreas(2.5)
  • Heart(2.3)
  • Kidney(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with NPY: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPY Gene

Orthologs for NPY Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NPY 34 35
  • 99.31 (n)
dog
(Canis familiaris)
 Mammalia NPY 34 35
  • 92.1 (n)
cow
(Bos Taurus)
 Mammalia NPY 34 35
  • 91.07 (n)
rat
(Rattus norvegicus)
 Mammalia LOC100912228 34
  • 88.66 (n)
mouse
(Mus musculus)
 Mammalia Npy 34 16 35
  • 87.97 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia NPY 35
  • 86 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NPY 35
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NPY 35 34
  • 84.19 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NPY 35
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia npy 34
  • 74.23 (n)
African clawed frog
(Xenopus laevis)
 Amphibia NPY 34
zebrafish
(Danio rerio)
 Actinopterygii npy 35 34
  • 65.59 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12071 34
Species where no ortholog for NPY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPY Gene

ENSEMBL:
Gene Tree for NPY (if available)
TreeFam:
Gene Tree for NPY (if available)

Paralogs for NPY Gene

Paralogs for NPY Gene

(3) SIMAP similar genes for NPY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NPY: view

Variants for NPY Gene

Sequence variations from dbSNP and Humsavar for NPY Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs16139 Benign 24,285,260(-) GCCCC(A/G/T)GTCGC intron-variant, reference, missense
rs1000220116 -- 24,287,641(+) TGATT(C/T)GGCAG intron-variant
rs1000322339 -- 24,282,226(+) TTATC(G/T)TAACA intron-variant, upstream-variant-2KB
rs1000676839 -- 24,287,967(+) AGGTT(C/T)GAGAA intron-variant
rs1000941389 -- 24,286,759(+) ATTCC(A/C)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPY Gene

Variant ID Type Subtype PubMed ID
esv2673027 CNV deletion 23128226
nsv517053 CNV gain+loss 19592680
nsv7393 OTHER inversion 18451855
nsv830927 CNV gain 17160897

Variation tolerance for NPY Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY Gene

Human Gene Mutation Database (HGMD)
NPY
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY Gene

Disorders for NPY Gene

MalaCards: The human disease database

(42) MalaCards diseases for NPY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autonomic neuropathy
adjustment disorder
  • adjustment disease
normal pressure hydrocephalus
  • low pressure hydrocephalus
eating disorder
  • eating disorders
temporal lobe epilepsy
  • epilepsy, temporal lobe
- elite association - COSMIC cancer census association via MalaCards
Search NPY in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPY

Genetic Association Database (GAD)
NPY
Human Genome Epidemiology (HuGE) Navigator
NPY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPY
genes like me logo Genes that share disorders with NPY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY Gene

Publications for NPY Gene

  1. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. (PMID: 19566775) Okahisa Y. … Kuroda S. (Psychiatry Clin. Neurosci. 2009) 3 22 46 64
  2. PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. (PMID: 19264362) SjAPholm L.K. … Lavebratt C. (J Affect Disord 2009) 3 22 46 64
  3. Genetic variation may influence obesity only under conditions of diet: analysis of three candidate genes. (PMID: 18815063) Aberle J. … Beil F.U. (Mol. Genet. Metab. 2008) 3 22 46 64
  4. Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. (PMID: 18828811) Wetherill L. … Foroud T. (Alcohol. Clin. Exp. Res. 2008) 3 22 46 64
  5. Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. (PMID: 18715275) Nishimura F.T. … Saijoh K. (Alcohol. Clin. Exp. Res. 2008) 3 22 46 64

Products for NPY Gene

  • Addgene plasmids for NPY

Sources for NPY Gene

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