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Set Analyses:

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NPY Gene

protein-coding GIFtS: 68
GCID: GC07P024290

Neuropeptide Y

Microbiology & Infectious Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Neuropeptide Y¹ ²
Prepro-Neuropeptide Y¹ ²
PYY4²
Pro-Neuropeptide Y²

External Ids:	HGNC: 7955¹	Entrez Gene: 4852²	Ensembl: ENSG00000122585⁷	OMIM: 162640⁵	UniProtKB: P01303³

Export aliases for NPY gene to outside databases

Previous GC identifers: GC07P023966 GC07P024032 GC07P024066 GC07P024097

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPY Gene:

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many

physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and

cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl

cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate

potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal

peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for

various metabolic and cardiovascular diseases. (provided by RefSeq, Nov 2009)

GeneCards Summary for NPY Gene:

NPY (neuropeptide Y) is a protein-coding gene. Diseases associated with NPY include reflex sympathetic dystrophy, and carcinoid tumor of lung. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is PYY.

UniProtKB/Swiss-Prot: NPY_HUMAN, P01303

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

summary for NPY Gene:

Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided

into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including

stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of

pituitary hormone release.

Gene Wiki entry for NPY (Neuropeptide Y) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000007.14 NC_018918.2 NT_007819.18

Regulatory elements:

Regulatory transcription factor binding sites in the NPY gene promoter:
AML1a AP-1 RREB-1 Bach2 ATF-2 Gfi-1 YY1 CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPY promoter sequence

Search Chromatin IP Primers for NPY

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p15.3

NPY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P024290: view genomic region (about GC identifiers)

Start:	24,323,782 bp from pter	End:	24,331,484 bp from pter
Size:	7,703 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 24,375,683-24,383,371

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPY_HUMAN, P01303 (See protein sequence)

Recommended Name: Pro-neuropeptide Y precursor

Size: 97 amino acids; 10851 Da

2 PDB 3D structures from and Proteopedia for NPY:

1QFA (3D)

1RON (3D)

Explore the universe of human proteins at neXtProt for NPY: NX_P01303

Explore proteomics data for NPY at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NPY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000896.1

ENSEMBL proteins:

ENSP00000242152 ENSP00000384364 ENSP00000385282

Reactome Protein details: P01303

NPY Human Recombinant Protein Products:

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	Novus Biologicals NPY Proteins Novus Biologicals NPY Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for NPY

NPY Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NPY
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NPY
	OriGene Antibodies for NPY OriGene Custom Antibody Services for NPY
	Novus Biologicals NPY Antibodies
	Abcam antibodies for NPY
	Cloud-Clone Corp. Antibodies for NPY
	ThermoFisher Antibodies for NPY
	LSBio Antibodies in human, mouse, rat for NPY

NPY Assay Products:

	EMD Millipore Kits and Assays for the Analysis of NPY
	OriGene Custom Assay Services for NPY
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NPY
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NPY Cloud-Clone Corp. CLIAs for NPY

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

2 InterPro protein domains:

IPR001955 Pancreatic_hormone-like

IPR020392 Pancreatic_hormone-like_CS

Graphical View of Domain Structure for InterPro Entry P01303

ProtoNet protein and cluster: P01303

1 Blocks protein domain: IPB001955 Pancreatic hormone

UniProtKB/Swiss-Prot: NPY_HUMAN, P01303

Similarity: Belongs to the NPY family

NPY for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NPY_HUMAN, P01303

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

Genatlas biochemistry entry for NPY:

neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic

regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein

lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high

serum cholesterol and LDL-cholesterol levels

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	1321422
GO:0005102	receptor binding	TAS	10698177
GO:0005179	hormone activity	--	--
GO:0005184	neuropeptide hormone activity	TAS	2427515

NPY for ontologies About GeneDecksing

Phenotypes:
10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Npy):

adipose tissue	behavior/neurological	digestive/alimentary	growth/size/body	homeostasis/metabolism
liver/biliary system	nervous system	normal	renal/urinary system	skeleton

NPY for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPY

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPY

miRNA Products:		miRTarBase miRNAs that target NPY: hsa-mir-335-5p (MIRT016709)

		Block miRNA regulation of human, mouse, rat NPY using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate NPY
		SwitchGear 3'UTR luciferase reporter plasmid: NPY 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NPY
		Predesigned siRNA for gene silencing in human, mouse, rat NPY

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NPY

Clone Products:		OriGene clones in human, mouse for NPY (see all 6) OriGene ORF clones in mouse, rat for NPY OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NPY (NM_000905)
		Sino Biological Human cDNA Clone for NPY
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NPY
		Browse ESI BIO Cell Lines and PureStem Progenitors for NPY

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NPY_HUMAN, P01303: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
nucleus	3
cytoskeleton	2
plasma membrane	2
endoplasmic reticulum	1
golgi apparatus	1
mitochondrion	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	--
GO:0005623	cell	TAS	2444979

NPY for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NPY About (see all 8)

See pathways by source

SuperPath

Contained pathways About

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			G alpha (i) signalling events	0.44

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Neuropeptides signaling through G protein alpha i and G protein alpha q

Neuropeptides signaling through G protein alpha i and G protein alpha q

0.46

RNA Polymerase I Promoter Opening

Alcoholism

0.34

Sympathetic Nerve Pathway (Neuroeffector Junction)

Sympathetic Nerve Pathway (Neuroeffector Junction)

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for NPY

Neuroscience

1 BioSystems Pathway for NPY

Endothelin

2 Reactome Pathways for NPY

	Peptide ligand-binding receptors
	G alpha (i) signalling events

1 PharmGKB Pathway for NPY

Sympathetic Nerve Pathway (Neuroeffector Junction)

2 Kegg Pathways (Kegg details for NPY):

	Adipocytokine signaling pathway
	Alcoholism

NPY for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including NPY:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Insulin Signaling Pathway in human mouse rat

Atherosclerosis in human mouse rat

Neurotrophins & Receptors in human mouse rat

Obesity in human mouse rat

Interactions:

GeneGlobe Interaction Network for NPY

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NPY (P01303^{2, 3} ENSP00000242152⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 172)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8090901 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884²^,³, ENSP00000188790⁴	MINT-8090736 I2D: score=1 STRING: ENSP00000188790
NPY1R	P25929³, ENSP00000354652⁴	I2D: score=2 STRING: ENSP00000354652
PMCH	P20382³, ENSP00000332225⁴	I2D: score=2 STRING: ENSP00000332225
MC4R	P32245³, ENSP00000299766⁴	I2D: score=1 STRING: ENSP00000299766

About this table

Gene Ontology (GO): Selected biological process terms (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	TAS	8132547
GO:0006928	cellular component movement	TAS	10488139
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8132547
GO:0007218	neuropeptide signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	10557353

NPY for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for NPY available from Tocris Bioscience About this table

Compound	Action	CAS #
BIIE 0246	Potent, selective non-peptide NPY Y2 receptor antagonist	[246146-55-4]
[Leu31,Pro34]-Neuropeptide Y (human, rat)	NPY Y1 receptor agonist	[132699-73-1]
BIBP 3226 trifluoroacetate	Mixed NPY Y1 and NPFF receptor antagonist	[159013-54-4]
Neuropeptide Y (human, rat)	Influences feeding and sexual behavior	[90880-35-6]
BIBO 3304 trifluoroacetate	Highly selective NPY Y1 receptor antagonist	[191868-14-1]

2 DrugBank Compounds for NPY About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-Aminoisobutyric Acid	--	--	target	--	10592235
L-Tyrosinamide	L-Tyrosine amide (see all 2)	4985-46-0	target	--	10592235

Selected Novoseek inferred chemical compound relationships for NPY gene (see all 135) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibp3226	87.3	39	8961073 (4), 9421306 (3), 9089810 (2), 9802409 (2) (see all 23)
prepro npy	87.2	27	17516289 (3), 11159860 (2), 19264362 (2), 11422604 (2) (see all 15)
biie0246	80.1	11	10725255 (3), 17265460 (1), 15716408 (1), 19837904 (1) (see all 6)
npys	79.6	7	19175376 (1), 17785501 (1), 19319516 (1), 19879900 (1)
norepinephrine	78.6	793	9630349 (8), 11080198 (8), 2346958 (7), 2174218 (6) (see all 99)
helospectin	77.3	17	8163401 (1), 10465504 (1), 8100109 (1), 8100111 (1) (see all 7)
bibo3304	73.1	7	12242085 (1), 17265460 (1), 15576634 (1), 19363600 (1) (see all 5)
sr 120819a	72.4	1	10858507 (1)
enterostatin	71.2	7	10605906 (1), 11732637 (1), 12612162 (1), 9208352 (1) (see all 6)
[pro...34...]npy	66.6	5	10737675 (2), 8961073 (1)

NPY for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NPY gene:

NM_000905.3

Unigene Cluster for NPY:

Neuropeptide Y

Hs.1832 [show with all ESTs]

Unigene Representative Sequence: BF680552

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000242152(uc003sww.2) ENST00000407573 ENST00000405982

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat NPY using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate NPY
		SwitchGear 3'UTR luciferase reporter plasmid: NPY 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NPY
		Predesigned siRNA for gene silencing in human, mouse, rat NPY

Clone Products:		OriGene clones in human, mouse for NPY (see all 6) OriGene ORF clones in mouse, rat for NPY OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NPY (NM_000905)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY

Primer Products:		OriGene qPCR primer pairs and template standards for NPY OriGene qSTAR qPCR primer pairs in human, mouse for NPY
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NPY
		QuantiTect SYBR Green Assays in human, mouse, rat NPY
		QuantiFast Probe-based Assays in human, mouse, rat NPY

Additional mRNA sequence:

AK312156.1 BC029497.1 K01911.1 M15789.1

3 DOTS entries:

DT.111515 DT.102821654 DT.65287365

Selected AceView cDNA sequences (see all 51):

CA772698 AU100303 AI198986 K01911 AA226171 AA532647 CK819427 BX101548

BQ721485 NM_000905 AA662733 AU108080 BM128788 BQ932266 AU077324 BV174647

AA662702 BQ925183 BC029497 CK819428 T28435 BV183949 AI199681 BQ899354

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NPY About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c
SP1:							-
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for NPY

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CATCCAAAAA

About this image

NPY expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 13) fully expand


Kidney (Urinary System) fully expand to see all 4 entries
Comma-shaped Body Cells Comma-shaped Body
Metanephros

Neurons
Cholinergic Amacrine Cells Inner Nuclear Layer
Motor neuron progenitor cells

Eye (Sensory Organs) fully expand to see all 3 entries
Cholinergic Amacrine Cells Inner Nuclear Layer

Brain (Nervous System) fully expand to see all 2 entries
Cerebellum

Motor Neurons (Nervous System)
Motor neuron progenitor cells

NPY Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NPY Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1832

UniProtKB/Swiss-Prot: NPY_HUMAN, P01303

Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells

of the adrenal medulla

Pathway & Disease-focused RT² Profiler PCR Arrays including NPY:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Insulin Signaling Pathway in human mouse rat

Atherosclerosis in human mouse rat

Neurotrophins & Receptors in human mouse rat

Obesity in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for NPY OriGene qSTAR qPCR primer pairs in human, mouse for NPY
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NPY
		QuantiTect SYBR Green Assays in human, mouse, rat NPY
		QuantiFast Probe-based Assays in human, mouse, rat NPY

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NPY gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Npy^{1 , 5}	neuropeptide Y^{1, 5}	87.97(n)¹ 92.78(a)¹		6 (24.04 cM)⁵ 109648¹ NM_023456.2¹ NP_075945.1¹ 49822710⁵
chicken (Gallus gallus)	Aves	NPY¹	neuropeptide Y	84.19(n) 84.54(a)		396464 NM_205473.1 NP_990804.1
lizard (Anolis carolinensis)	Reptilia	NPY⁶	neuropeptide Y	86(a)	1 ↔ 1	6(30853219-30869567)
African clawed frog (Xenopus laevis)	Amphibia	NPY²	neuropeptide Y	76.83(n)		L11294.1
zebrafish (Danio rerio)	Actinopterygii	npy²	neuropeptide Y	75.73(n)		30281 NM_131074.1

ENSEMBL Gene Tree for NPY (if available)
TreeFam Gene Tree for NPY (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NPY gene

PYY²

3 SIMAP similar genes for NPY using alignment to 2 protein entries: NPY_HUMAN (see all proteins):

PYY3 PYY PPY

NPY for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs16139^1,2,,4	C,F,H	non-pathogenic¹	24298858(-)	`GCCCCA/GGTCGC`	2	P L	mis¹ ese³		13		MN NA NS EA EU	6759
rs3857723^1,2	C,F,H	--	24295806(-)	`ATACTA/GTTGAG`	1	--	us2k¹		20		EA NA NS WA CSA	928
rs3857724^1,2	C,F,H	--	24295987(-)	`ATGTGT/CTTACA`	1	--	us2k¹		16		NS EA NA WA CSA	792
rs16479^1,2	C,F,H	--	24296041(-)	`TATTCT/CGAGGG`	1	--	us2k¹		7		NS EA NA	542
rs146451656^1,2		--	24296271(+)	`GAAGAA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs16149^1,2	C,F,A,H	--	24296304(+)	`TTACCG/AAAGGC`	1	--	us2k¹		27		NS EA NA WA CSA	2770
rs16148^1,2	C,F,A,H	--	24296317(+)	`TGTCTC/TGTAAG`	1	--	us2k¹		23		NS EA NA WA CSA	2350
rs7807047^1,2	C,F,A,H	--	24296336(+)	`AGCAAC/TTCTGA`	1	--	us2k¹		15		NS EA NA WA	1640
rs3025124^1,2	C,F,H	--	24296367(-)	`ACATAT/CGCTGA`	1	--	us2k¹		4		NS EA	418
rs185407435^1,2		--	24296567(+)	`TTTTAA/GCATTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NPY (24323782 - 24331484 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for NPY: About this table

Variant ID	Type	Subtype	PubMed ID
esv2673027	CNV	Deletion	23128226
nsv830927	CNV	Gain	17160897
nsv517053	CNV	Gain+Loss	19592680
nsv7393	OTHER	Inversion	18451855

Human Gene Mutation Database (HGMD): NPY

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162640 OMIM disorders: --

Selected diseases for NPY (see all 181):
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reflex sympathetic dystrophy carcinoid tumor of lung neural crest tumor neuroepithelioma

x-linked dystonia-parkinsonism leptin deficiency normal pressure hydrocephalus stress cardiomyopathy

ganglioneuroblastoma fibromyalgia status epilepticus subependymal giant cell astrocytoma

post-traumatic stress disorder bulimia nervosa hydrocephalus social phobia

complex regional pain syndrome labyrinthitis tendinosis anxiety disorder

10 diseases from the University of Copenhagen DISEASES database for NPY:

Hypertension Diabetes mellitus Hyperinsulinism Huntington's disease

Alcohol dependence Kidney failure Hyperglycemia Brain disease

Phaeochromocytoma Schizophrenia

NPY for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for NPY gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
obesity	67.2	128	10923281 (4), 17603492 (3), 10207720 (3), 9222646 (3) (see all 68)
appetite disorders	62.6	2	10657510 (1), 7902088 (1)
anorexia nervosa	51.1	21	9439531 (2), 19947235 (2), 11820995 (2), 15073570 (2) (see all 10)
pheochromocytoma	44.6	91	7593641 (7), 10526260 (7), 17470513 (5), 7955545 (5) (see all 25)
epilepsy temporal lobe	44.1	16	11466452 (2), 15337376 (1), 1361332 (1), 10082852 (1) (see all 12)
neuroepithelioma	44	7	2159234 (2), 2384178 (1), 9165460 (1), 12094613 (1)
eating disorders	37.6	9	9439531 (1), 10853924 (1), 1959027 (1), 8861189 (1) (see all 6)
alcoholism	35.2	44	15897713 (4), 16611091 (3), 11696660 (3), 18241322 (3) (see all 20)
epilepsy	32.8	35	17979775 (2), 11466452 (2), 15337376 (1), 10082852 (1) (see all 21)
essential hypertension	29.3	29	16563248 (3), 8848409 (3), 7666676 (2), 7670647 (2) (see all 14)

Genetic Association Database (GAD): NPY
Human Genome Epidemiology (HuGE) Navigator: NPY (105 documents)

Export disorders for NPY gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPY gene, integrated from 10 sources (see all 2128):
(articles sorted by number of sources associating them with NPY)

Utopia: connect your pdf to the dynamic
world of online information

A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. (PubMed id 15897713)^{1, 4, 9} Mottagui-Tabar S....Heilig M. (Alcohol. Clin. Exp. Res. 2005)
No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C>T) and schizophrenia. (PubMed id 19150389)^{1, 4, 9} Inoue Y....Nakamura J. (Neurosci. Lett. 2009)
Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. (PubMed id 18241322)^{1, 4, 9} Zill P....Soyka M. (Alcohol. Clin. Exp. Res. 2008)
[Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. (PubMed id 16459651)^{1, 4, 9} Wang H.S....He L. (Yi Chuan Xue Bao 2005)
Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans. (PubMed id 12875921)^{1, 4, 9} Itokawa M....Yoshikawa T. (Neurosci. Lett. 2003)
Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism. (PubMed id 11696660)^{1, 4, 9} Ilveskoski E....Alho H. (Alcohol. Clin. Exp. Res. 2001)
PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. (PubMed id 19264362)^{1, 4, 9} SjAPholm L.K....Lavebratt C. (J Affect Disord 2009)
Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes. (PubMed id 17516289)^{1, 4, 9} Jaakkola U....Kallio J. (amp 2007)
Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. (PubMed id 16568137)^{1, 4, 9} van Rossum C.T....Seidell J.C. (Int J Obes (Lond) 2006)
Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men. (PubMed id 15926114)^{1, 4, 9} Nordman S....Gu H.F. (amp 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4852	HGNC: 7955	AceView: NPY	Ensembl:ENSG00000122585	euGenes: HUgn4852
ECgene: NPY	Kegg: 4852	H-InvDB: NPY

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NPY	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NPY	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Neuropeptide_Y

Intellectual Property for NPY gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NPY gene:
Search GeneIP for patents involving NPY

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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NPY Gene

Neuropeptide Y

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Hyperinsulinemia
Anxiety Disorders
Genetic Susceptibility
essential hypertension
von Hippel-Lindau Disease
Anterior open bite
Eating Disorders
Erythroleukemia
dysplasia
Puberty Delayed
Glucose Intolerance
Left ventricular failure
Liver diseases
Intoxication
Common Migraine
Stress Psychological
Edema
Schizophrenia
Ganglioneuroblastoma
Hypoglycemia
Obstruction
Mood Disorders
Diabetes Mellitus Insulin-Dependent
Hypotension
Respiratory failure
Colorectal Carcinoma
RENAL DISEASE
Status Epilepticus
Epilepsy Temporal Lobe
Epilepsy
Multiple Sclerosis
Malnutrition
Inflammation
Stress Disorders Posttraumatic
Neuroepithelioma
Sex Cord-Stromal Tumor
AUTONOMIC NEUROPATHY
prostate cancer
Cardiovascular Diseases
Tumors
Pheochromocytoma
Bulimia Nervosa
Depressive disorder
Rhinitis
metabolic disorder
Autoimmunity
Liver Cirrhosis
Cushing Syndrome
Coronary Heart Disease
Huntington Disease
Appetite Disorders
major depression
Cirrhosis
BREAST CARCINOMA
glaucoma
Anorexia Nervosa
Prurigo
Glioma
Reflex Sympathetic Dystrophy
ARTERIAL VESSELS
Hirschsprung Disease
Atrial Fibrillation
Hydrocephalus Normal Pressure
Osteoarthritis
Alzheimers Disease
Diabetes Mellitus
Heart Failure Congestive
Osteoporosis
congenital malformation
Alcoholism
Seizures Febrile
Effects Cardiovascular
Carcinoma Renal Cell
HEART FAILURE
Myocardial Infarction
Neuroendocrine Tumors
Alcohol withdrawal
Insulin Resistance
Ascites
impaired glucose tolerance
Scar
Ganglioneuroma
Delirium Tremens
OBESITY
Nasal Obstruction
Apnea Sleep
neuroblastoma metastatic
Vascular Diseases
Cerebral Ischemia
liver metastases
Prader-Willi Syndrome
Fibromyalgia
Vitiligo
CORONARY SPASM

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NPY Gene

Neuropeptide Y

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