External Ids for NPY Gene
Previous GeneCards Identifiers for NPY Gene
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
GeneCards Summary for NPY Gene
NPY (Neuropeptide Y) is a Protein Coding gene. Diseases associated with NPY include autonomic neuropathy and temporal lobe epilepsy. Among its related pathways are Adipocytokine signaling pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is PYY.
UniProtKB/Swiss-Prot for NPY Gene
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.