Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NPY Gene

protein-coding   GIFtS: 68
GCID: GC07P024290

Neuropeptide Y

  See NPY-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Neuropeptide Y1 2
Prepro-Neuropeptide Y1 2
PYY42
Pro-Neuropeptide Y2

External Ids:    HGNC: 79551   Entrez Gene: 48522   Ensembl: ENSG000001225857   OMIM: 1626405   UniProtKB: P013033   

Export aliases for NPY gene to outside databases

Previous GC identifers: GC07P023966 GC07P024032 GC07P024066 GC07P024097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NPY Gene:
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many
physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and
cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl
cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate
potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal
peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for
various metabolic and cardiovascular diseases. (provided by RefSeq, Nov 2009)

GeneCards Summary for NPY Gene:
NPY (neuropeptide Y) is a protein-coding gene. Diseases associated with NPY include neural crest tumor, and stress cardiomyopathy. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is PYY.

UniProtKB/Swiss-Prot: NPY_HUMAN, P01303
Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

summary for NPY Gene:
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided
into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including
stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of
pituitary hormone release.

Gene Wiki entry for NPY (Neuropeptide Y) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPY gene promoter:
         AML1a   AP-1   RREB-1   Bach2   ATF-2   Gfi-1   YY1   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPY promoter sequence
   Search Chromatin IP Primers for NPY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

NPY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPY gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P024290:  view genomic region     (about GC identifiers)

Start:
24,323,782 bp from pter      End:
24,331,484 bp from pter
Size:
7,703 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 24,375,683-24,383,371     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NPY_HUMAN, P01303 (See protein sequence)
Recommended Name: Pro-neuropeptide Y precursor  
Size: 97 amino acids; 10851 Da
2 PDB 3D structures from and Proteopedia for NPY:
1QFA (3D)        1RON (3D)    

Explore the universe of human proteins at neXtProt for NPY: NX_P01303

Explore proteomics data for NPY at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NPY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000896.1  
    ENSEMBL proteins: 
     ENSP00000242152   ENSP00000384364   ENSP00000385282  
    Reactome Protein details: P01303

    NPY Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NPY
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NPY
    GenScript Custom Purified and Recombinant Proteins Services for NPY
    Novus Biologicals NPY Proteins
    Novus Biologicals NPY Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPY

     
    Search eBioscience for Proteins for NPY 

    NPY Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NPY
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NPY 
    OriGene Antibodies for NPY
    OriGene Custom Antibody Services for NPY
    Novus Biologicals NPY Antibodies
    Abcam antibodies for NPY
    Cloud-Clone Corp. Antibodies for NPY
    ThermoFisher Antibodies for NPY
    LSBio Antibodies in human, mouse, rat for NPY

    NPY Assay Products:

    EMD Millipore Kits and Assays for the Analysis of NPY
    OriGene Custom Assay Services for NPY
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPY
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPY
    Cloud-Clone Corp. CLIAs for NPY
    Search eBioscience for ELISAs for NPY 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR001955 Pancreatic_hormone-like
     IPR020392 Pancreatic_hormone-like_CS

    Graphical View of Domain Structure for InterPro Entry P01303

    ProtoNet protein and cluster: P01303

    1 Blocks protein domain: IPB001955 Pancreatic hormone

    UniProtKB/Swiss-Prot: NPY_HUMAN, P01303
    Similarity: Belongs to the NPY family


    Find genes that share domains with NPY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPY_HUMAN, P01303
    Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

         Genatlas biochemistry entry for NPY:
    neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic
    regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein
    lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high
    serum cholesterol and LDL-cholesterol levels

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IEA--
    GO:0004930G-protein coupled receptor activity TAS1321422
    GO:0005102receptor binding TAS10698177
    GO:0005179hormone activity ----
    GO:0005184neuropeptide hormone activity TAS2427515
         
    Find genes that share ontologies with NPY           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Npy):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     liver/biliary system  nervous system  normal  renal/urinary system  skeleton 

    Find genes that share phenotypes with NPY           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPY

    miRNA
    Products:
        
    miRTarBase miRNAs that target NPY:
    hsa-mir-335-5p (MIRT016709)

    Block miRNA regulation of human, mouse, rat NPY using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NPY
    SwitchGear 3'UTR luciferase reporter plasmidNPY 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NPY
    Predesigned siRNA for gene silencing in human, mouse, rat NPY

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPY

    Clone
    Products:
         
    OriGene clones in human, mouse for NPY (see all 6)
    OriGene ORF clones in mouse, rat for NPY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPY (NM_000905)
    Sino Biological Human cDNA Clone for NPY
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY
    Addgene plasmids for NPY 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPY
    Browse ESI BIO Cell Lines and PureStem Progenitors for NPY 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NPY_HUMAN, P01303: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0005623cell TAS2444979

    Find genes that share ontologies with NPY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NPY About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4RNA Polymerase I Promoter Opening
    Alcoholism0.34
    5Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Neuroeffector Junction)


    Find genes that share SuperPaths with NPY           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NPY
        Neuroscience

    1 BioSystems Pathway for NPY
        Endothelin


    2 Reactome Pathways for NPY
        Peptide ligand-binding receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for NPY
        Sympathetic Nerve Pathway (Neuroeffector Junction)

    2 Kegg Pathways  (Kegg details for NPY):
        Adipocytokine signaling pathway
    Alcoholism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Atherosclerosis in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NPY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPY (P013032, 3 ENSP000002421524) via UniProtKB, MINT, STRING, and/or I2D (see all 172)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8090901 I2D: score=1 STRING: ENSP00000353731
    FAPQ128842, 3, ENSP000001887904MINT-8090736 I2D: score=1 STRING: ENSP00000188790
    NPY1RP259293, ENSP000003546524I2D: score=2 STRING: ENSP00000354652
    PMCHP203823, ENSP000003322254I2D: score=2 STRING: ENSP00000332225
    MC4RP322453, ENSP000002997664I2D: score=1 STRING: ENSP00000299766
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport TAS8132547
    GO:0006928cellular component movement TAS10488139
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8132547
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007268synaptic transmission TAS10557353

    Find genes that share ontologies with NPY           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPY available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIIE 0246 Potent, selective non-peptide NPY Y2 receptor antagonist [246146-55-4]
    [Leu31,Pro34]-Neuropeptide Y (human, rat) NPY Y1 receptor agonist[132699-73-1]
    BIBP 3226 trifluoroacetateMixed NPY Y1 and NPFF receptor antagonist[159013-54-4]
    Neuropeptide Y (human, rat) Influences feeding and sexual behavior[90880-35-6]
    BIBO 3304 trifluoroacetateHighly selective NPY Y1 receptor antagonist[191868-14-1]

    2 DrugBank Compounds for NPY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Aminoisobutyric Acid-- --target--10592235
    L-TyrosinamideL-Tyrosine amide (see all 2)4985-46-0target--10592235

    Selected Novoseek inferred chemical compound relationships for NPY gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibp3226 87.3 39 8961073 (4), 9421306 (3), 9089810 (2), 9802409 (2) (see all 23)
    prepro npy 87.2 27 17516289 (3), 11159860 (2), 19264362 (2), 11422604 (2) (see all 15)
    biie0246 80.1 11 10725255 (3), 17265460 (1), 15716408 (1), 19837904 (1) (see all 6)
    npys 79.6 7 19175376 (1), 17785501 (1), 19319516 (1), 19879900 (1)
    norepinephrine 78.6 793 9630349 (8), 11080198 (8), 2346958 (7), 2174218 (6) (see all 99)
    helospectin 77.3 17 8163401 (1), 10465504 (1), 8100109 (1), 8100111 (1) (see all 7)
    bibo3304 73.1 7 12242085 (1), 17265460 (1), 15576634 (1), 19363600 (1) (see all 5)
    sr 120819a 72.4 1 10858507 (1)
    enterostatin 71.2 7 10605906 (1), 11732637 (1), 12612162 (1), 9208352 (1) (see all 6)
    [pro...34...]npy 66.6 5 10737675 (2), 8961073 (1)



    Find genes that share compounds with NPY           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NPY gene: 
    NM_000905.3  

    Unigene Cluster for NPY:

    Neuropeptide Y
    Hs.1832  [show with all ESTs]
    Unigene Representative Sequence: BF680552
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242152(uc003sww.2) ENST00000407573 ENST00000405982
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NPY using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NPY
    SwitchGear 3'UTR luciferase reporter plasmidNPY 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NPY
    Predesigned siRNA for gene silencing in human, mouse, rat NPY
    Clone
    Products:
         
    OriGene clones in human, mouse for NPY (see all 6)
    OriGene ORF clones in mouse, rat for NPY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPY (NM_000905)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY
    Addgene plasmids for NPY 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NPY
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY
      QuantiTect SYBR Green Assays in human, mouse, rat NPY
      QuantiFast Probe-based Assays in human, mouse, rat NPY

    Additional mRNA sequence: 

    AK312156.1 BC029497.1 K01911.1 M15789.1 

    3 DOTS entries:

    DT.111515  DT.102821654  DT.65287365 

    Selected AceView cDNA sequences (see all 51):

    CA772698 AU100303 AI198986 K01911 AA226171 AA532647 CK819427 BX101548 
    BQ721485 NM_000905 AA662733 AU108080 BM128788 BQ932266 AU077324 BV174647 
    AA662702 BQ925183 BC029497 CK819428 T28435 BV183949 AI199681 BQ899354 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NPY    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:                    -                                 
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for NPY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NPY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCAAAAA
    NPY Expression
    About this image


    NPY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Comma-shaped Body Cells Comma-shaped Body
             Metanephros
     
     Neurons
             Cholinergic Amacrine Cells Inner Nuclear Layer
             Motor neuron progenitor cells
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Motor Neurons (Nervous System)
             Motor neuron progenitor cells
    NPY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1832

    UniProtKB/Swiss-Prot: NPY_HUMAN, P01303
    Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells
    of the adrenal medulla

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPY: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Atherosclerosis in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NPY
    OriGene qSTAR qPCR primer pairs in human, mouse for NPY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY
    QuantiTect SYBR Green Assays in human, mouse, rat NPY
    QuantiFast Probe-based Assays in human, mouse, rat NPY
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NPY gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npy1 , 5 neuropeptide Y1, 5 87.97(n)1
    92.78(a)1
      6 (24.04 cM)5
    1096481  NM_023456.21  NP_075945.11 
     498227105 
    chicken
    (Gallus gallus)
    Aves NPY1 neuropeptide Y 84.19(n)
    84.54(a)
      396464  NM_205473.1  NP_990804.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPY6
    neuropeptide Y
    86(a)
    1 ↔ 1
    6(30853219-30869567)
    African clawed frog
    (Xenopus laevis)
    Amphibia NPY2 neuropeptide Y 76.83(n)    L11294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npy2 neuropeptide Y 75.73(n)   30281  NM_131074.1 


    ENSEMBL Gene Tree for NPY (if available)
    TreeFam Gene Tree for NPY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NPY gene
    PYY2  
    3 SIMAP similar genes for NPY using alignment to 2 protein entries:     NPY_HUMAN (see all proteins):
    PYY3    PYY    PPY

    Find genes that share paralogs with NPY           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NPY (see all 255)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs161391,2,,4
    C,F,Hnon-pathogenic124298858(-) GCCCCA/GGTCGC 2 P L mis1 ese313Minor allele frequency- G:0.03MN NA NS EA EU 6759
    rs38577231,2
    C,F,H--24295806(-) ATACTA/GTTGAG 1 -- us2k120Minor allele frequency- C:0.00EA NA NS WA CSA 928
    rs38577241,2
    C,F,H--24295987(-) ATGTGT/CTTACA 1 -- us2k116Minor allele frequency- C:0.01NS EA NA WA CSA 792
    rs164791,2
    C,F,H--24296041(-) TATTCT/CGAGGG 1 -- us2k17Minor allele frequency- C:0.05NS EA NA 542
    rs1464516561,2
    --24296271(+) GAAGAA/GCTCTA 1 -- us2k10--------
    rs161491,2
    C,F,A,H--24296304(+) TTACCG/AAAGGC 1 -- us2k127Minor allele frequency- A:0.30NS EA NA WA CSA 2770
    rs161481,2
    C,F,A,H--24296317(+) TGTCTC/TGTAAG 1 -- us2k123Minor allele frequency- T:0.46NS EA NA WA CSA 2350
    rs78070471,2
    C,F,A,H--24296336(+) AGCAAC/TTCTGA 1 -- us2k115Minor allele frequency- T:0.01NS EA NA WA 1640
    rs30251241,2
    C,F,H--24296367(-) ACATAT/CGCTGA 1 -- us2k14Minor allele frequency- C:0.01NS EA 418
    rs1854074351,2
    --24296567(+) TTTTAA/GCATTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPY (24323782 - 24331484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NPY:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673027CNV Deletion23128226
    nsv830927CNV Gain17160897
    nsv517053CNV Gain+Loss19592680
    nsv7393OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): NPY
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPY
    DNA2.0 Custom Variant and Variant Library Synthesis for NPY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 162640    OMIM disorders: --

    Selected diseases for NPY (see all 23):    
    About MalaCards
    neural crest tumor    stress cardiomyopathy    reflex sympathetic dystrophy    x-linked dystonia-parkinsonism
    normal pressure hydrocephalus    neuroepithelioma    ganglioneuroblastoma    subependymal giant cell astrocytoma
    status epilepticus    fibromyalgia    tendinosis    social phobia
    bulimia nervosa    hepatorenal syndrome    post-traumatic stress disorder    carcinoid syndrome
    generalized anxiety disorder    anorexia nervosa    seasonal affective disorder    essential hypertension

    10 diseases from the University of Copenhagen DISEASES database for NPY:
    Hypertension     Diabetes mellitus     Hyperinsulinism     Huntington's disease
    Alcohol dependence     Kidney failure     Hyperglycemia     Brain disease
    Phaeochromocytoma     Schizophrenia

    Find genes that share disorders with NPY           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NPY gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 67.2 128 10923281 (4), 17603492 (3), 10207720 (3), 9222646 (3) (see all 68)
    appetite disorders 62.6 2 10657510 (1), 7902088 (1)
    anorexia nervosa 51.1 21 9439531 (2), 19947235 (2), 11820995 (2), 15073570 (2) (see all 10)
    pheochromocytoma 44.6 91 7593641 (7), 10526260 (7), 17470513 (5), 7955545 (5) (see all 25)
    epilepsy temporal lobe 44.1 16 11466452 (2), 15337376 (1), 1361332 (1), 10082852 (1) (see all 12)
    neuroepithelioma 44 7 2159234 (2), 2384178 (1), 9165460 (1), 12094613 (1)
    eating disorders 37.6 9 9439531 (1), 10853924 (1), 1959027 (1), 8861189 (1) (see all 6)
    alcoholism 35.2 44 15897713 (4), 16611091 (3), 11696660 (3), 18241322 (3) (see all 20)
    epilepsy 32.8 35 17979775 (2), 11466452 (2), 15337376 (1), 10082852 (1) (see all 21)
    essential hypertension 29.3 29 16563248 (3), 8848409 (3), 7666676 (2), 7670647 (2) (see all 14)

    Genetic Association Database (GAD): NPY
    Human Genome Epidemiology (HuGE) Navigator: NPY (105 documents)

    Export disorders for NPY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NPY gene, integrated from 10 sources (see all 2128):
    (articles sorted by number of sources associating them with NPY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. (PubMed id 15897713)1, 4, 9 Mottagui-Tabar S....Heilig M. (Alcohol. Clin. Exp. Res. 2005)
    2. No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C&gt;T) and schizophrenia. (PubMed id 19150389)1, 4, 9 Inoue Y....Nakamura J. (Neurosci. Lett. 2009)
    3. Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. (PubMed id 18241322)1, 4, 9 Zill P....Soyka M. (Alcohol. Clin. Exp. Res. 2008)
    4. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. (PubMed id 16459651)1, 4, 9 Wang H.S....He L. (Yi Chuan Xue Bao 2005)
    5. Association between a novel polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans. (PubMed id 12875921)1, 4, 9 Itokawa M....Yoshikawa T. (Neurosci. Lett. 2003)
    6. Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism. (PubMed id 11696660)1, 4, 9 Ilveskoski E....Alho H. (Alcohol. Clin. Exp. Res. 2001)
    7. PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. (PubMed id 19264362)1, 4, 9 SjAPholm L.K....Lavebratt C. (J Affect Disord 2009)
    8. Impact of the Leu7Pro polymorphism of preproNPY on diurnal NPY and hormone secretion in type 2 diabetes. (PubMed id 17516289)1, 4, 9 Jaakkola U....Kallio J. (amp 2007)
    9. Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults. (PubMed id 16568137)1, 4, 9 van Rossum C.T....Seidell J.C. (Int J Obes (Lond) 2006)
    10. Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men. (PubMed id 15926114)1, 4, 9 Nordman S....Gu H.F. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4852 HGNC: 7955 AceView: NPY Ensembl:ENSG00000122585 euGenes: HUgn4852
    ECgene: NPY Kegg: 4852 H-InvDB: NPY

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NPY Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NPY Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Neuropeptide_Y

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NPY gene:
    Search GeneIP for patents involving NPY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NPY
     EMD Millipore Kits and Assays for the Analysis of NPY
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NPY   OriGene RNAi products in human, mouse, rat for NPY  
     OriGene qPCR primer pairs and template standards for NPY   OriGene Protein Over-expression Lysate for NPY  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPY  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPY   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPY   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPY   OriGene Custom Protein Services for NPY  

     
     
     Block miRNA regulation of human, mouse, rat NPY using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NPY
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPY Predesigned siRNA for gene silencing in human, mouse, rat NPY
     QuantiFast Probe-based Assays in human, mouse, rat NPY QuantiTect SYBR Green Assays in human, mouse, rat NPY
     PCR Arrays including human, mouse, rat NPY Search Chromatin IP Primers for NPY
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPY  GeneGlobe Interaction Network for NPY
     Regulatory tfbs in NPY promoter
     GenScript Custom Purified and Recombinant Proteins Services for NPY GenScript cDNA clones with any tag delivered in your preferred vector for NPY
     GenScript Custom Assay Services for NPY GenScript Custom overexpressing Cell Line Services for NPY
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NPY 

     Tocris compounds for NPY
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NPY
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NPY antibodies
     NPY proteins
     NPY lysates
     Antibodies for NPY
     See all of Abcam's Antibodies, Kits and Proteins for NPY
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NPY
     Antibodies for NPY
     ELISAs for NPY
     CLIAs for NPY



     Browse ESI BIO Cell Lines and PureStem Progenitors for NPY
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPY
     SwitchGear 3'UTR luciferase reporter plasmids for NPY
     SwitchGear Promoter luciferase reporter plasmids for NPY
     ThermoFisher Antibodies for NPY
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPY
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPY
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPY
     LSBio Antibodies in human, mouse, rat for NPY
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for NPY
      Search eBioscience for proteins for NPY
      Search eBioscience for elisas for NPY
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPY gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4