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Aliases for NPY Gene

Aliases for NPY Gene

  • Neuropeptide Y 2 3
  • Prepro-Neuropeptide Y 2 3
  • PYY4 3

External Ids for NPY Gene

Previous GeneCards Identifiers for NPY Gene

  • GC07P023966
  • GC07P024032
  • GC07P024066
  • GC07P024097

Summaries for NPY Gene

Entrez Gene Summary for NPY Gene

  • This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for NPY Gene

NPY (Neuropeptide Y) is a Protein Coding gene. Diseases associated with NPY include adjustment disorder and normal pressure hydrocephalus. Among its related pathways are Signaling by GPCR and Neuroscience. GO annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is PYY.

UniProtKB/Swiss-Prot for NPY Gene

  • NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

Tocris Summary for NPY Gene

  • Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.

Gene Wiki entry for NPY Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPY Gene

Genomics for NPY Gene

Regulatory Elements for NPY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPY Gene

24,284,163 bp from pter
24,291,865 bp from pter
7,703 bases
Plus strand

Genomic View for NPY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPY Gene

Proteins for NPY Gene

  • Protein details for NPY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pro-neuropeptide Y
    Protein Accession:

    Protein attributes for NPY Gene

    97 amino acids
    Molecular mass:
    10851 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NPY Gene

neXtProt entry for NPY Gene

Proteomics data for NPY Gene at MOPED

Post-translational modifications for NPY Gene

  • The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NPY (Neuropeptide Y/NPY)
  • Cell Signaling Technology (CST) Antibodies for NPY (NPY)

No data available for DME Specific Peptides for NPY Gene

Domains & Families for NPY Gene

Gene Families for NPY Gene

Protein Domains for NPY Gene

Suggested Antigen Peptide Sequences for NPY Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPY family.
  • Belongs to the NPY family.
genes like me logo Genes that share domains with NPY: view

Function for NPY Gene

Molecular function for NPY Gene

GENATLAS Biochemistry:
neuropeptide Y,melanostatin,expressed in brain (hypothalamus),adrenals,heart,involved in the hypothalamic regulation of energy balance by stimulating food intake and favoring energy storage through increased lipoprotein lipase activity in white adipose tissue,inhibited by leptin,with a polymorphism putatively associated with high serum cholesterol and LDL-cholesterol levels
UniProtKB/Swiss-Prot Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

Gene Ontology (GO) - Molecular Function for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding --
GO:0004930 G-protein coupled receptor activity TAS 1321422
GO:0005102 receptor binding TAS 8132547
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity TAS 2427515
genes like me logo Genes that share ontologies with NPY: view
genes like me logo Genes that share phenotypes with NPY: view

Animal Model Products

miRNA for NPY Gene

miRTarBase miRNAs that target NPY

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NPY Gene

Localization for NPY Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPY Gene


Subcellular locations from

Jensen Localization Image for NPY Gene COMPARTMENTS Subcellular localization image for NPY gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0005623 cell TAS 2444979
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with NPY: view

Pathways & Interactions for NPY Gene

genes like me logo Genes that share pathways with NPY: view

Pathways by source for NPY Gene

PCR Array Products

SIGNOR curated interactions for NPY Gene


Gene Ontology (GO) - Biological Process for NPY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IDA 18603306
GO:0006816 calcium ion transport TAS 8132547
GO:0006928 movement of cell or subcellular component TAS 10488139
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8132547
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with NPY: view

Drugs & Compounds for NPY Gene

(86) Drugs for NPY Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit Pharma 96
Apraclonidine Approved Pharma 4
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Baclofen Approved Pharma 90
Bethanechol Approved Pharma Full agonist, Agonist 3

(56) Additional Compounds for NPY Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Leu31,Pro34]-Neuropeptide Y (porcine)
BIBP 3226 trifluoroacetate
GR 231118
Neuropeptide Y (human, rat)
Pancreatic Polypeptide (human)
genes like me logo Genes that share compounds with NPY: view

Transcripts for NPY Gene

mRNA/cDNA for NPY Gene

Unigene Clusters for NPY Gene

Neuropeptide Y:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPY Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -

Relevant External Links for NPY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPY Gene

mRNA expression in normal human tissues for NPY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPY Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.2), Prostate (x8.4), Brain - Caudate (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for NPY Gene

This gene is overexpressed in Cerebrospinal fluid (37.4), Seminal vesicle (17.9), and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPY Gene

SOURCE GeneReport for Unigene cluster for NPY Gene Hs.1832

mRNA Expression by UniProt/SwissProt for NPY Gene

Tissue specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla
genes like me logo Genes that share expression patterns with NPY: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NPY Gene

Orthologs for NPY Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPY Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPY 35
  • 91.07 (n)
  • 94.85 (a)
NPY 36
  • 95 (a)
(Canis familiaris)
Mammalia NPY 35
  • 92.1 (n)
  • 95.88 (a)
NPY 36
  • 96 (a)
(Mus musculus)
Mammalia Npy 35
  • 87.97 (n)
  • 92.78 (a)
Npy 16
Npy 36
  • 93 (a)
(Pan troglodytes)
Mammalia NPY 35
  • 99.31 (n)
  • 98.97 (a)
NPY 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100912228 35
  • 88.66 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia NPY 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NPY 36
  • 86 (a)
(Gallus gallus)
Aves NPY 35
  • 84.19 (n)
  • 84.54 (a)
NPY 36
  • 85 (a)
(Anolis carolinensis)
Reptilia NPY 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npy 35
  • 74.23 (n)
  • 79.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia NPY 35
(Danio rerio)
Actinopterygii npy 35
  • 65.59 (n)
  • 67.74 (a)
npy 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12071 35
Species with no ortholog for NPY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPY Gene

Gene Tree for NPY (if available)
Gene Tree for NPY (if available)

Paralogs for NPY Gene

Paralogs for NPY Gene

(3) SIMAP similar genes for NPY Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NPY: view

Variants for NPY Gene

Sequence variations from dbSNP and Humsavar for NPY Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs5571 - 24,285,304(+) TGTGC(A/C)TGGGT missense, reference
rs5572 -- 24,285,324(+) GAGGC(A/G)TACCC synonymous-codon, reference
rs5573 -- 24,285,390(+) TACTC(A/C/G/T)GCGCT synonymous-codon, reference
rs5574 -- 24,289,514(+) CGATC(C/T)AGCCC reference, synonymous-codon
rs5575 -- 24,291,710(+) TCTCT(G/T)GCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPY Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2673027 CNV Deletion 23128226
nsv517053 CNV Gain+Loss 19592680
nsv830927 CNV Gain 17160897

Variation tolerance for NPY Gene

Residual Variation Intolerance Score: 54.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPY Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPY Gene

Disorders for NPY Gene

MalaCards: The human disease database

(42) MalaCards diseases for NPY Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
adjustment disorder
  • adjustment reaction
normal pressure hydrocephalus
  • low pressure hydrocephalus
reflex sympathetic dystrophy
  • reflex sympathetic dystrophy syndrome
eating disorder
  • eating disorders
- elite association
Search NPY in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPY Gene

Publications for NPY Gene

  1. Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. (PMID: 20203197) Chee M.J. … Colmers W.F. (J. Neurosci. 2010) 23 67
  2. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. (PMID: 20332211) Sheriff S. … Amlal H. (Mol. Cancer Res. 2010) 23 67
  3. Laboratory parameters and appetite regulators in patients with anorexia nervosa. (PMID: 20511732) Himmerich H. … Sheldrick A.J. (J Psychiatr Pract 2010) 23 67
  4. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. (PMID: 19837904) Brothers S.P. … Hodder P.S. (Mol. Pharmacol. 2010) 23 67
  5. Behavioral effects of neuropeptides in rodent models of depression and anxiety. (PMID: 20026211) Rotzinger S. … Tan L.A. (Peptides 2010) 23 67

Products for NPY Gene

Sources for NPY Gene

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