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NPW Gene

protein-coding   GIFtS: 47
GCID: GC16P002059

Neuropeptide W

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide W1 2     PPNPW2 3
Prepro-Neuropeptide W1 2     hPPL82 3
Preproprotein L82 3     L82
PPL82 3     L8C2

External Ids:    HGNC: 305091   Entrez Gene: 2838692   Ensembl: ENSG000001839717   OMIM: 6079975   UniProtKB: Q8N7293   

Export aliases for NPW gene to outside databases

Previous GC identifers: GC16P002012 GC16P002013 GC16P002069 GC16P001993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPW Gene:
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two
G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol
secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein
is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NPW Gene:
NPW (neuropeptide W) is a protein-coding gene. Diseases associated with NPW include adrenocortical carcinoma, and eating disorder. GO annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary
gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By
similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30

Gene Wiki entry for NPW Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPW gene promoter:
         AREB6   Egr-3   Elk-1   Pax-5   AP-1   USF-1   USF-1:USF-2   Nkx2-5   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NPW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPW gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002059:  view genomic region     (about GC identifiers)

Start:
2,059,927 bp from pter      End:
2,070,756 bp from pter
Size:
10,830 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729 (See protein sequence)
Recommended Name: Neuropeptide W precursor  
Size: 165 amino acids; 18048 Da
Sequence caution: Sequence=BAC07172.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for NPW: NX_Q8N729

Explore proteomics data for NPW at MOPED


See NPW Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001092926.2  
ENSEMBL proteins: 
 ENSP00000457009   ENSP00000456974   ENSP00000330070  
Reactome Protein details: Q8N729

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR013297 Neuropept_BW_pre
 IPR013299 Neuropept_W_pre

Graphical View of Domain Structure for InterPro Entry Q8N729

ProtoNet protein and cluster: Q8N729

UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
Similarity: Belongs to the neuropeptide B/W family


NPW for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NPW_HUMAN, Q8N729
Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary
gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By
similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0005515protein binding IPI12401809
     
NPW for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NPW_HUMAN, Q8N729: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
golgi apparatus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

NPW for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NPW About    
See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.44
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Neuropeptides signaling through G protein alpha i and G protein alpha q
Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Reactome Pathways for NPW
    Peptide ligand-binding receptors
G alpha (i) signalling events



NPW for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPW
Interactions:

    GeneGlobe Interaction Network for NPW

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NPW (Q8N7293 ENSP000003300704) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
InteractantInteraction Details
GeneCardExternal ID(s)
NPBWR1P481453, ENSP000003302844I2D: score=2 STRING: ENSP00000330284
NPBWR2P481463, ENSP000003587834I2D: score=1 STRING: ENSP00000358783
ADRA2AENSP000002801554STRING: ENSP00000280155
ADRA2BENSP000003872814STRING: ENSP00000387281
C5AR1ENSP000003471974STRING: ENSP00000347197
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway IDA12401809
GO:0007218neuropeptide signaling pathway IEA--
GO:0007631feeding behavior IDA12959997

NPW for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NPW

1 Novoseek inferred chemical compound relationship for NPW gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
corticosterone 33.7 1 16394174 (1)



NPW for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NPW gene: 
NM_001099456.2  

Unigene Cluster for NPW:

Neuropeptide W
Hs.233533  [show with all ESTs]
Unigene Representative Sequence: BC171886
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000567649 ENST00000566435 ENST00000329610(uc002coh.4)
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Additional mRNA sequence: 

AB084276.1 AL365519.1 AL365521.1 BC150533.1 BC150534.1 BC171886.1 

1 DOTS entry:

DT.70104398 

15 AceView cDNA sequences:

AI868441 AL365521 BM985063 AI500303 AI990964 AB084276 AW007531 BG654790 
BI821183 AA593569 AL365519 BG501428 BG499966 AA744804 BE271520 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPW expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGAAAAAAAA
NPW Expression
About this image

NPW Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NPW Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.233533

UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
Tissue specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in
testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected
at high levels in lymphoblastic leukemia and colorectal adenocarcinoma

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for NPW gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Npw1 , 5 neuropeptide W1, 5 77.49(n)1
73.5(a)1
  17 (12.45 cM)5
3810731  NM_001099664.11  NP_001093134.11 
 246573305 


ENSEMBL Gene Tree for NPW (if available)
TreeFam Gene Tree for NPW (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NPW (see all 89)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1929636401,2
--2067569(+) GCTCAC/TTGCAA 1 -- us2k10--------
rs1846268721,2
--2067619(+) CTCCTA/GAGTAG 1 -- us2k10--------
rs1438345751,2
--2067681(+) TAGAGA/TTGGGA 1 -- us2k10--------
rs1472338121,2
--2067728(+) ACCTCA/GTGACA 1 -- us2k10--------
rs1889422971,2
--2067837(+) GCCAGG/TCTGGT 1 -- us2k10--------
rs1819555041,2
--2067846(+) GTCTTG/TAACTC 1 -- us2k10--------
rs579234511,2
C,F--2068118(+) CATTGT/GCTGGA 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs1133749741,2
C,F--2068125(+) TGGAGG/ATCAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1164451811,2
C,F--2068202(+) CTGACA/GTGGTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs1862926521,2
--2068436(+) AGTCAC/TAAGGT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NPW (2059927 - 2070756 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for NPW (see all 26):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
dgv336n27CNV Loss19166990
dgv2545n71CNV Loss21882294
dgv2546n71CNV Loss21882294
nsv905048CNV Loss21882294
nsv905101CNV Loss21882294
dgv2551n71CNV Loss21882294
dgv2540n71CNV Loss21882294
nsv905102CNV Loss21882294
nsv523037CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607997    OMIM disorders: --

9 diseases for NPW:    
About MalaCards
adrenocortical carcinoma    eating disorder    bronchitis    bronchiolitis
obesity    lymphoblastic leukemia    adenocarcinoma    neuronitis
leukemia

1 disease from the University of Copenhagen DISEASES database for NPW:
Bronchiolitis

NPW for disorders           About GeneDecksing


Export disorders for NPW gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NPW gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with NPW)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3, 9 Brezillon S.... Parmentier M. (J. Biol. Chem. 2003)
  2. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PubMed id 12130646)1, 2, 9 Shimomura Y.... Fujino M. (J. Biol. Chem. 2002)
  3. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PubMed id 12118011)1, 3 Fujii R....Fujino M. (J. Biol. Chem. 2002)
  4. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PubMed id 16394174)1, 9 Mondal M.S....Nakazato M. (J. Endocrinol. 2006)
  5. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PubMed id 16847439)1, 9 Singh G. and Davenport A.P. (Br. J. Pharmacol. 2006)
  6. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PubMed id 12719537)1, 9 Tanaka H.... Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  7. Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering. (PubMed id 22826747)1 Green B.R....Bulaj G. (ACS Chem Neurosci 2011)
  8. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
  9. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
  10. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PubMed id 15797961)1 Mazzocchi G....Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283869 HGNC: 30509 AceView: PPL8 Ensembl:ENSG00000183971 euGenes: HUgn283869
ECgene: NPW H-InvDB: NPW

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NPW Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NPW gene:
Search GeneIP for patents involving NPW

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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