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Aliases for NPW Gene

Aliases for NPW Gene

  • Neuropeptide W 2 3 5
  • Prepro-Neuropeptide W 2 3
  • Preproprotein L8 3 4
  • PPNPW 3 4
  • HPPL8 3 4
  • PPL8 3 4
  • L8C 3
  • L8 3

External Ids for NPW Gene

Previous GeneCards Identifiers for NPW Gene

  • GC16P002012
  • GC16P002013
  • GC16P002069
  • GC16P001993
  • GC16P002059

Summaries for NPW Gene

Entrez Gene Summary for NPW Gene

  • The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPW Gene

NPW (Neuropeptide W) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for NPW Gene

  • Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Gene Wiki entry for NPW Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPW Gene

Genomics for NPW Gene

Regulatory Elements for NPW Gene

Enhancers for NPW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002014 0.9 Ensembl ENCODE 10.9 +6.1 6104 2.4 ARID4B SIN3A ZNF48 BRCA1 ZNF2 ZNF121 KLF7 ZNF548 ZNF263 SP3 ENSG00000255513 ENSG00000261505 SNORA64 ENSG00000260954 ENSG00000260051 LOC105371055 HN1L NPW ZNF598 SNHG9
GH16F002020 0.4 ENCODE 10 +10.2 10229 0.2 POLR2A RNF2 SCRT2 ZBTB33 ZNF48 NPW BRICD5 RN7SL219P SLC9A3R2
GH16F001997 0.5 ENCODE 8.8 -11.8 -11754 2.1 PKNOX1 MLX CREB3L1 SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 ZNF207 TMEM204 ZNF598 TPSG1 ENSG00000260954 ENSG00000255513 NPW SYNGR3 GFER ENSG00000260107
GH16F001982 0.8 ENCODE 8.4 -25.4 -25440 3.3 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS GFER SNORD60 SNHG19 ENSG00000255513 NPW SYNGR3 NOXO1
GH16F002003 1.6 FANTOM5 Ensembl ENCODE 7.8 -2.7 -2705 7.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000226890 ENSG00000200059 ENSG00000261240 PRSS29P ENSG00000261123 ENSG00000260646 LOC105371049 HN1L IFT140 ENSG00000255513
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NPW on UCSC Golden Path with GeneCards custom track

Promoters for NPW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502393 -426 1801 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for NPW Gene

Chromosome:
16
Start:
2,009,926 bp from pter
End:
2,020,755 bp from pter
Size:
10,830 bases
Orientation:
Plus strand

Genomic View for NPW Gene

Genes around NPW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPW Gene

Proteins for NPW Gene

  • Protein details for NPW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N729-NPW_HUMAN
    Recommended name:
    Neuropeptide W
    Protein Accession:
    Q8N729

    Protein attributes for NPW Gene

    Size:
    165 amino acids
    Molecular mass:
    18048 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC07172.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NPW Gene

Post-translational modifications for NPW Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPW Gene

Domains & Families for NPW Gene

Gene Families for NPW Gene

Protein Domains for NPW Gene

Suggested Antigen Peptide Sequences for NPW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N729

UniProtKB/Swiss-Prot:

NPW_HUMAN :
  • Belongs to the neuropeptide B/W family.
Family:
  • Belongs to the neuropeptide B/W family.
genes like me logo Genes that share domains with NPW: view

Function for NPW Gene

Molecular function for NPW Gene

UniProtKB/Swiss-Prot Function:
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Gene Ontology (GO) - Molecular Function for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005515 protein binding IPI 12401809
genes like me logo Genes that share ontologies with NPW: view
genes like me logo Genes that share phenotypes with NPW: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPW

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPW Gene

Localization for NPW Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPW Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPW Gene COMPARTMENTS Subcellular localization image for NPW gene
Compartment Confidence
extracellular 5
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPW: view

Pathways & Interactions for NPW Gene

genes like me logo Genes that share pathways with NPW: view

Gene Ontology (GO) - Biological Process for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007631 feeding behavior IDA 12959997
genes like me logo Genes that share ontologies with NPW: view

No data available for SIGNOR curated interactions for NPW Gene

Drugs & Compounds for NPW Gene

(1) Drugs for NPW Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NPW: view

Transcripts for NPW Gene

mRNA/cDNA for NPW Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPW Gene

Neuropeptide W:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPW Gene

No ASD Table

Relevant External Links for NPW Gene

GeneLoc Exon Structure for
NPW
ECgene alternative splicing isoforms for
NPW

Expression for NPW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPW Gene

This gene is overexpressed in Liver (x16.8) and Pituitary (x5.0).

Protein differential expression in normal tissues from HIPED for NPW Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPW Gene



Protein tissue co-expression partners for NPW Gene

NURSA nuclear receptor signaling pathways regulating expression of NPW Gene:

NPW

SOURCE GeneReport for Unigene cluster for NPW Gene:

Hs.233533

mRNA Expression by UniProt/SwissProt for NPW Gene:

Q8N729-NPW_HUMAN
Tissue specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.
genes like me logo Genes that share expression patterns with NPW: view

Primer Products

Orthologs for NPW Gene

This gene was present in the common ancestor of mammals.

Orthologs for NPW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPW 34 35
  • 99.04 (n)
mouse
(Mus musculus)
Mammalia Npw 34 16 35
  • 77.49 (n)
rat
(Rattus norvegicus)
Mammalia Npw 34
  • 73.89 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NPW 35
  • 59 (a)
OneToOne
Species where no ortholog for NPW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPW Gene

ENSEMBL:
Gene Tree for NPW (if available)
TreeFam:
Gene Tree for NPW (if available)

Paralogs for NPW Gene

No data available for Paralogs for NPW Gene

Variants for NPW Gene

Sequence variations from dbSNP and Humsavar for NPW Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111292378 -- 2,019,455(+) CTGTC(C/G)TCCCA upstream-variant-2KB
rs111434916 -- 2,018,653(+) GTCTC(-/AA)AAAAA upstream-variant-2KB
rs111462107 -- 2,018,420(+) GGCGG(A/G)CGGAT upstream-variant-2KB
rs112050738 -- 2,018,740(+) GCCTC(C/G)CGGGT upstream-variant-2KB
rs11248906 -- 2,020,199(+) TGTGG(C/G)AGACG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NPW Gene

Variant ID Type Subtype PubMed ID
dgv336n27 CNV loss 19166990
dgv4858n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv457348 CNV loss 19166990
nsv471070 CNV gain 18288195
nsv471072 CNV loss 18288195
nsv521569 CNV loss 19592680
nsv523037 CNV loss 19592680
nsv571189 CNV loss 21841781
nsv952901 CNV deletion 24416366

Variation tolerance for NPW Gene

Gene Damage Index Score: 7.38; 81.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPW Gene

Human Gene Mutation Database (HGMD)
NPW
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPW Gene

Disorders for NPW Gene

Relevant External Links for NPW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPW

No disorders were found for NPW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPW Gene

Publications for NPW Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PMID: 12130646) Shimomura Y. … Fujino M. (J. Biol. Chem. 2002) 3 4 22 64
  3. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PMID: 16394174) Mondal M.S. … Nakazato M. (J. Endocrinol. 2006) 3 22 64
  4. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G. … Davenport A.P. (Br. J. Pharmacol. 2006) 3 22 64
  5. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H. … Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 22 64

Products for NPW Gene

Sources for NPW Gene

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