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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPW Gene

protein-coding   GIFtS: 49
GCID: GC16P002059

Neuropeptide W

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuropeptide W1 2     PPNPW2 3
Prepro-Neuropeptide W1 2     hPPL82 3
Preproprotein L82 3     L82
PPL82 3     L8C2

External Ids:    HGNC: 305091   Entrez Gene: 2838692   Ensembl: ENSG000001839717   OMIM: 6079975   UniProtKB: Q8N7293   

Export aliases for NPW gene to outside databases

Previous GC identifers: GC16P002012 GC16P002013 GC16P002069 GC16P001993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPW Gene:
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two
G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol
secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein
is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NPW Gene: 
NPW (neuropeptide W) is a protein-coding gene. Diseases associated with NPW include adrenocortical carcinoma, and eating disorder, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include protein binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary
gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By
similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30

Gene Wiki entry for NPW Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPW gene promoter:
         AREB6   Egr-3   Elk-1   Pax-5   AP-1   USF-1   USF-1:USF-2   Nkx2-5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NPW

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NPW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPW gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002059:  view genomic region     (about GC identifiers)

Start:
2,059,927 bp from pter      End:
2,070,756 bp from pter
Size:
10,830 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729 (See protein sequence)
Recommended Name: Neuropeptide W precursor  
Size: 165 amino acids; 18048 Da
Subcellular location: Secreted
Sequence caution: Sequence=BAC07172.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for NPW: NX_Q8N729

Explore proteomics data for NPW at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N729

  • NPW Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPW Protein Expression
    REFSEQ proteins: NP_001092926.2  
    ENSEMBL proteins: 
     ENSP00000457009   ENSP00000456974   ENSP00000330070  
    Reactome Protein details: Q8N729
    Human Recombinant Protein Products for NPW: 
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    Cloud-Clone Corp. Proteins for NPW 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    NPW for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR013297 Neuropept_BW_pre
     IPR013299 Neuropept_W_pre

    Graphical View of Domain Structure for InterPro Entry Q8N729

    ProtoNet protein and cluster: Q8N729

    UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
    Similarity: Belongs to the neuropeptide B/W family


    NPW for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPW_HUMAN, Q8N729
    Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary
    gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By
    similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IEA--
    GO:0005515protein binding IPI12401809
         
    NPW for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPW About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NPW
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    5/7        Reactome Pathways for NPW (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events



    NPW for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPW

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/150 Interacting proteins for NPW (Q8N7293 ENSP000003300704) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPBWR1P481453, ENSP000003302844I2D: score=2 STRING: ENSP00000330284
    NPBWR2P481463, ENSP000003587834I2D: score=1 STRING: ENSP00000358783
    ADRA2AENSP000002801554STRING: ENSP00000280155
    CCR8ENSP000003264324STRING: ENSP00000326432
    GALENSP000002656434STRING: ENSP00000265643
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA12401809
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007631feeding behavior IDA12959997

    NPW for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPW for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPW

    1 Novoseek inferred chemical compound relationship for NPW gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    corticosterone 33.7 1 16394174 (1)

    Search CenterWatch for drugs/clinical trials and news about NPW

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPW gene: 
    NM_001099456.2  

    Unigene Cluster for NPW:

    Neuropeptide W
    Hs.233533  [show with all ESTs]
    Unigene Representative Sequence: BC171886
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567649 ENST00000566435 ENST00000329610(uc002coh.4)
    miRNA
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    Additional mRNA sequence: 

    AB084276.1 AL365519.1 AL365521.1 BC150533.1 BC150534.1 BC171886.1 

    1 DOTS entry:

    DT.70104398 

    15 AceView cDNA sequences:

    AB084276 AL365521 AI500303 BM985063 AI990964 AI868441 AA593569 AW007531 
    BI821183 BG654790 AL365519 BG499966 BG501428 AA744804 BE271520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPW expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAAAAAAAA
    NPW Expression
    About this image


    See NPW Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPW

    SOURCE GeneReport for Unigene cluster: Hs.233533

    UniProtKB/Swiss-Prot: NPW_HUMAN, Q8N729
    Tissue specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in
    testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected
    at high levels in lymphoblastic leukemia and colorectal adenocarcinoma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for NPW gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npw1 , 5 neuropeptide W1, 5 78.16(n)1
    74.14(a)1
      17 (12.45 cM)5
    3810731  NM_001099664.11  NP_001093134.11 
     246573305 


    ENSEMBL Gene Tree for NPW (if available)
    TreeFam Gene Tree for NPW (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 SNPs in NPW are shown (see all 89)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929636401,2
    --2067569(+) GCTCAC/TTGCAA 1 -- us2k10--------
    rs1846268721,2
    --2067619(+) CTCCTA/GAGTAG 1 -- us2k10--------
    rs1438345751,2
    --2067681(+) TAGAGA/TTGGGA 1 -- us2k10--------
    rs1472338121,2
    --2067728(+) ACCTCA/GTGACA 1 -- us2k10--------
    rs1889422971,2
    --2067837(+) GCCAGG/TCTGGT 1 -- us2k10--------
    rs1819555041,2
    --2067846(+) GTCTTG/TAACTC 1 -- us2k10--------
    rs579234511,2
    C,F--2068118(+) CATTGT/GCTGGA 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1133749741,2
    C,F--2068125(+) TGGAGG/ATCAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1164451811,2
    C,F--2068202(+) CTGACA/GTGGTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1862926521,2
    --2068436(+) AGTCAC/TAAGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPW (2059927 - 2070756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for NPW (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv336n27CNV Loss19166990
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    nsv905101CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2540n71CNV Loss21882294
    nsv905102CNV Loss21882294
    nsv523037CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607997    OMIM disorders: --

    9 diseases for NPW:    About MalaCards
    adrenocortical carcinoma    eating disorder    bronchitis    bronchiolitis
    obesity    lymphoblastic leukemia    adenocarcinoma    neuronitis
    leukemia

    1 disease from the University of Copenhagen DISEASES database for NPW:
    Bronchiolitis

    NPW for disorders           About GeneDecksing


    Export disorders for NPW gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPW gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with NPW)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3, 9 Brezillon S.... Parmentier M. (2003)
    2. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PubMed id 12130646)1, 2, 9 Shimomura Y.... Fujino M. (2002)
    3. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PubMed id 12118011)1, 3 Fujii R....Fujino M. (2002)
    4. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PubMed id 16394174)1, 9 Mondal M.S....Nakazato M. (2006)
    5. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PubMed id 16847439)1, 9 Singh G. and Davenport A.P. (2006)
    6. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PubMed id 12719537)1, 9 Tanaka H.... Yanagisawa M. (2003)
    7. Analgesic neuropeptide W suppresses seizures in the br ain revealed by rational repositioning and peptide engineering. (PubMed id 22826747)1 Green B.R....Bulaj G. (2011)
    8. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
    9. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
    10. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PubMed id 15797961)1 Mazzocchi G....Nussdorfer G.G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283869 HGNC: 30509 AceView: PPL8 Ensembl:ENSG00000183971 euGenes: HUgn283869
    ECgene: NPW H-InvDB: NPW

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPW Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPW gene:
    Search GeneIP for patents involving NPW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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