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Aliases for NPW Gene

Aliases for NPW Gene

  • Neuropeptide W 2 3
  • Prepro-Neuropeptide W 2 3
  • Preproprotein L8 3 4
  • PPNPW 3 4
  • HPPL8 3 4
  • PPL8 3 4
  • L8C 3
  • L8 3

External Ids for NPW Gene

Summaries for NPW Gene

Entrez Gene Summary for NPW Gene

  • The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPW Gene

NPW (Neuropeptide W) is a Protein Coding gene. Diseases associated with NPW include colorectal adenocarcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for NPW Gene

  • Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Gene Wiki entry for NPW Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPW Gene

Genomics for NPW Gene

Genomic Location for NPW Gene

Start:
2,009,926 bp from pter
End:
2,020,755 bp from pter
Size:
10,830 bases
Orientation:
Plus strand

Genomic View for NPW Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPW Gene

Regulatory Elements for NPW Gene

Proteins for NPW Gene

  • Protein details for NPW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N729-NPW_HUMAN
    Recommended name:
    Neuropeptide W
    Protein Accession:
    Q8N729
    Secondary Accessions:

    Protein attributes for NPW Gene

    Size:
    165 amino acids
    Molecular mass:
    18048 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC07172.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NPW Gene

Proteomics data for NPW Gene at MOPED

Post-translational modifications for NPW Gene

No Post-translational modifications

Other Protein References for NPW Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPW Gene

Domains for NPW Gene

Gene Families for NPW Gene

HGNC:

Protein Domains for NPW Gene

UniProtKB/Swiss-Prot:

NPW_HUMAN
Family:
  • Belongs to the neuropeptide B/W family.:
    • Q8N729
genes like me logo Genes that share domains with NPW: view

Function for NPW Gene

Molecular function for NPW Gene

UniProtKB/Swiss-Prot Function: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Gene Ontology (GO) - Molecular Function for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005515 protein binding IPI 12401809
genes like me logo Genes that share ontologies with NPW: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPW Gene

Localization for NPW Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPW Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPW Gene COMPARTMENTS Subcellular localization image for NPW gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPW: view

Pathways for NPW Gene

genes like me logo Genes that share pathways with NPW: view

Gene Ontology (GO) - Biological Process for NPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007631 feeding behavior IDA 12959997
genes like me logo Genes that share ontologies with NPW: view

Compounds for NPW Gene

(1) Novoseek inferred chemical compound relationships for NPW Gene

Compound -log(P) Hits PubMed IDs
corticosterone 33.7 1
genes like me logo Genes that share compounds with NPW: view

Transcripts for NPW Gene

mRNA/cDNA for NPW Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPW Gene

Neuropeptide W:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPW Gene

No ASD Table

Relevant External Links for NPW Gene

GeneLoc Exon Structure for
NPW
ECgene alternative splicing isoforms for
NPW

Expression for NPW Gene

mRNA expression in normal human tissues for NPW Gene

mRNA differential expression in normal tissues according to GTEx for NPW Gene

This gene is overexpressed in Liver (16.8) and Pituitary (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPW Gene

SOURCE GeneReport for Unigene cluster for NPW Gene Hs.233533

mRNA Expression by UniProt/SwissProt for NPW Gene

Q8N729-NPW_HUMAN
Tissue specificity: Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma
genes like me logo Genes that share expressions with NPW: view

Orthologs for NPW Gene

This gene was present in the common ancestor of mammals.

Orthologs for NPW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPW 36
  • 99.04 (n)
  • 99.28 (a)
NPW 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPW 37
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Npw 36
  • 77.49 (n)
  • 73.5 (a)
Npw 16
Npw 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npw 36
  • 73.89 (n)
  • 74.17 (a)
Species with no ortholog for NPW:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPW Gene

ENSEMBL:
Gene Tree for NPW (if available)
TreeFam:
Gene Tree for NPW (if available)

Paralogs for NPW Gene

No data available for Paralogs for NPW Gene

Variants for NPW Gene

Sequence variations from dbSNP and Humsavar for NPW Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2286470 -- 2,019,692(+) CTCCG(C/T)CCCTC utr-variant-5-prime
rs2286471 -- 2,020,163(+) AGGCT(C/T)CTCTC reference, missense
rs2286472 - 2,020,567(+) GGTGG(A/C)CCCCG reference, missense
rs3217040 -- 2,020,326(+) AGGGG(-/A)GAGAG intron-variant
rs4344746 -- 2,019,356(+) GGGGA(C/G)TCACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPW Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2555n71 CNV Gain+Loss 21882294
nsv905094 CNV Gain 21882294
nsv905095 CNV Gain 21882294
nsv457348 CNV Loss 19166990
nsv905101 CNV Loss 21882294
nsv905102 CNV Loss 21882294
dgv2556n71 CNV Loss 21882294
nsv905105 CNV Loss 21882294

Relevant External Links for NPW Gene

HapMap Linkage Disequilibrium report
NPW

Disorders for NPW Gene

(1) University of Copenhagen DISEASES for NPW Gene

genes like me logo Genes that share disorders with NPW: view

No data available for UniProtKB/Swiss-Prot for NPW Gene

Publications for NPW Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PMID: 12130646) Shimomura Y. … Fujino M. (J. Biol. Chem. 2002) 3 4 23
  3. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PMID: 16394174) Mondal M.S. … Nakazato M. (J. Endocrinol. 2006) 3 23
  4. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H. … Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23
  5. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G. … Davenport A.P. (Br. J. Pharmacol. 2006) 3 23

Products for NPW Gene

Sources for NPW Gene

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