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Aliases for NPVF Gene

Aliases for NPVF Gene

  • Neuropeptide VF Precursor 2 3
  • C7orf9 3 4
  • RFRP 3 4
  • Pro-FMRFamide-Related Neuropeptide VF 3
  • FMRFamide-Related Peptide Precursor 2
  • RFamide-Related Peptide Precursor 2
  • Chromosome 7 Open Reading Frame 9 2
  • FMRFamide-Related Peptides 3
  • FMRFamide-Related Peptide 3
  • RFamide-Related Peptide 3
  • Neuropeptide NPVF 3

External Ids for NPVF Gene

Previous HGNC Symbols for NPVF Gene

  • C7orf9

Previous GeneCards Identifiers for NPVF Gene

  • GC07M025231

Summaries for NPVF Gene

GeneCards Summary for NPVF Gene

NPVF (Neuropeptide VF Precursor) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for NPVF Gene

  • Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPVF Gene

Genomics for NPVF Gene

Regulatory Elements for NPVF Gene

Genomic Location for NPVF Gene

Start:
25,224,570 bp from pter
End:
25,228,486 bp from pter
Size:
3,917 bases
Orientation:
Minus strand

Genomic View for NPVF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPVF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPVF Gene

Proteins for NPVF Gene

  • Protein details for NPVF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCQ7-NPVF_HUMAN
    Recommended name:
    Pro-FMRFamide-related neuropeptide VF
    Protein Accession:
    Q9HCQ7
    Secondary Accessions:
    • A4D164
    • Q7LE27
    • Q96PI9

    Protein attributes for NPVF Gene

    Size:
    196 amino acids
    Molecular mass:
    22309 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NPVF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPVF Gene

Proteomics data for NPVF Gene at MOPED

Post-translational modifications for NPVF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPVF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPVF Gene

Domains for NPVF Gene

Gene Families for NPVF Gene

HGNC:

Protein Domains for NPVF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPVF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCQ7

UniProtKB/Swiss-Prot:

NPVF_HUMAN :
  • Q9HCQ7
Family:
  • Belongs to the FARP (FMRFamide related peptide) family.
genes like me logo Genes that share domains with NPVF: view

Function for NPVF Gene

Molecular function for NPVF Gene

UniProtKB/Swiss-Prot Function: Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.

Phenotypes for NPVF Gene

GenomeRNAi human phenotypes for NPVF:
genes like me logo Genes that share phenotypes with NPVF: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPVF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPVF Gene

Localization for NPVF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPVF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPVF Gene COMPARTMENTS Subcellular localization image for NPVF gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for NPVF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NPVF: view

Pathways for NPVF Gene

SuperPathways for NPVF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPVF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 11025660
GO:0032277 negative regulation of gonadotropin secretion IDA 20027225
genes like me logo Genes that share ontologies with NPVF: view

No data available for Pathways by source for NPVF Gene

Compounds for NPVF Gene

(1) HMDB Compounds for NPVF Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with NPVF: view

Transcripts for NPVF Gene

mRNA/cDNA for NPVF Gene

(14) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPVF Gene

Neuropeptide VF precursor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPVF

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NPVF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPVF Gene

No ASD Table

Relevant External Links for NPVF Gene

GeneLoc Exon Structure for
NPVF
ECgene alternative splicing isoforms for
NPVF

Expression for NPVF Gene

mRNA expression in normal human tissues for NPVF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPVF Gene

This gene is overexpressed in Brain - Hypothalamus (46.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NPVF Gene

SOURCE GeneReport for Unigene cluster for NPVF Gene Hs.60473

mRNA Expression by UniProt/SwissProt for NPVF Gene

Q9HCQ7-NPVF_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus.
genes like me logo Genes that share expressions with NPVF: view

In Situ Assay Products

Orthologs for NPVF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPVF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPVF 35
  • 99.32 (n)
  • 98.47 (a)
NPVF 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPVF 35
  • 81.52 (n)
  • 74.09 (a)
NPVF 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPVF 35
  • 86.84 (n)
  • 77.44 (a)
NPVF 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npvf 35
  • 74.01 (n)
  • 60.75 (a)
Npvf 16
Npvf 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPVF 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPVF 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npvf 35
  • 75.94 (n)
  • 61.5 (a)
chicken
(Gallus gallus)
Aves GNIH 36
  • 50 (a)
OneToOne
NPVF 35
  • 61.74 (n)
  • 55.03 (a)
lizard
(Anolis carolinensis)
Reptilia NPVF 36
  • 35 (a)
OneToOne
Species with no ortholog for NPVF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPVF Gene

ENSEMBL:
Gene Tree for NPVF (if available)
TreeFam:
Gene Tree for NPVF (if available)

Paralogs for NPVF Gene

No data available for Paralogs for NPVF Gene

Variants for NPVF Gene

Sequence variations from dbSNP and Humsavar for NPVF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs877833 -- 25,228,135(+) CTGTC(A/G)TGCTA intron-variant
rs877834 - 25,228,315(+) ATTTG(C/T)CATAA reference, missense
rs877835 -- 25,228,475(+) TGCAG(C/T)CCAAT utr-variant-5-prime
rs886354 - 25,228,344(-) GTGAT(C/G)TCCAA missense, reference
rs978095 -- 25,224,937(-) GTTAC(A/G)TAAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPVF Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887845 CNV Loss 21882294
nsv522075 CNV Loss 19592680
nsv819946 CNV Loss 19587683

Relevant External Links for NPVF Gene

HapMap Linkage Disequilibrium report
NPVF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPVF Gene

Disorders for NPVF Gene

(1) University of Copenhagen DISEASES for NPVF Gene

Relevant External Links for NPVF

Genetic Association Database (GAD)
NPVF
Human Genome Epidemiology (HuGE) Navigator
NPVF
genes like me logo Genes that share disorders with NPVF: view

No data available for UniProtKB/Swiss-Prot for NPVF Gene

Publications for NPVF Gene

  1. Genomic structure and assessment of the retinally expressed RFamide- related peptide gene in dominant cystoid macular dystrophy. (PMID: 11951088) Schulz H.L. … Weber B.H.F. (Mol. Vis. 2002) 2 3 4 23
  2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PMID: 11025660) Hinuma S. … Fujino M. (Nat. Cell Biol. 2000) 3 4 23
  3. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. (PMID: 20027225) Ubuka T. … Bentley G.E. (PLoS ONE 2009) 3 4
  4. EST mining of the UniGene dataset to identify retina-specific genes. (PMID: 11173868) Stoehr H. … Weber B.H.F. (Cytogenet. Cell Genet. 2000) 2 3
  5. Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. (PMID: 11481330) Liu Q. … Austin C.P. (J. Biol. Chem. 2001) 3 4

Products for NPVF Gene

Sources for NPVF Gene

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