NPTXR Gene
protein-coding GIFtS: 51
GCID: GC22M039214
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neuronal pentraxin receptor
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Aliases for NPTXR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Neuronal Pentraxin Receptor1 2 | | NPR2 |
Export aliases for NPTXR gene to outside databasesPrevious GC identifers: GC22M035828 GC22M037457 GC22M037538 GC22M022180 |
Summaries for NPTXR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NPTXR: This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integralmembrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport intothe synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may alsobe true for mouse and human, based on strong sequence conservation amongst these species. (provided by RefSeq, Jul2008) UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating thesynaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) Gene Wiki entry for NPTXR
|
Genomic Views for NPTXR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NPTXR gene promoter: HOXA9 HOXA9B AML1a Pax-5 Lmo2 AP-4 Evi-1 Meis-1b HOXA5 Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for NPTXR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTXR |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1NPTXR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M039214: view genomic region
(about GC identifiers)
Start:
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39,214,457 bp from pter |
End:
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39,240,017 bp from pter |
Size:
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25,561 bases |
Orientation:
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minus strand |
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Proteins for NPTXR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502 (See
protein sequence)Recommended Name: Neuronal pentraxin receptor Size: 500 amino acids; 52846 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49(TCBP49/RCN2) (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=CAA15430.3; Type=Erroneous gene model prediction;Explore the universe of human proteins at neXtProt for NPTXR: NX_O95502
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95502 NPTXR Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_055108.2 ENSEMBL proteins: ENSP00000327545 Human Recombinant Protein Products for NPTXR:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NPTXR for ontologies About GeneDecksing
NPTXR Antibody Products: Assay Products for NPTXR: |
Protein
Domains / Families for NPTXR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPTXR for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95502ProtoNet protein and cluster: O95502 1 Blocks protein family: IPB001759 Pentaxin
UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502Similarity: Contains 1 pentaxin domain |
Function for NPTXR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: NPTXR_HUMAN, O95502Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating thesynaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) Genatlas biochemistry entry for NPTXR:neuronal pentraxin receptor,interacting with NPTX1,NPTX2 and taipoxin-associated calcium binding protein 49,putativelyinvolved in the clearance of synaptic debris
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008029 | pentraxin receptor activity |
-- | -- | | GO:0032403 | protein complex binding |
-- | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NPTXR for ontologies About GeneDecksing
Phenotypes: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nptxr):
NPTXR for phenotypes About GeneDecksing
Animal Models: Mouse knock-out Nptxrtm1Mspn for NPTXR
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPTXR (NM_014293) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPTXR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTXR  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR |
|
Pathways & Interactions for NPTXR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPTXR
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 4 Interacting proteins for NPTXR (O955023 ENSP000003275454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042542 | response to hydrogen peroxide |
-- | -- |
NPTXR for ontologies About GeneDecksing
|
Drugs & Compounds for NPTXR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NPTXR for compounds About GeneDecksing
Browse Tocris compounds for NPTXR
1 HMDB Compound for NPTXR About this table 2 Novoseek chemical compound relationships for NPTXR gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cgmp |
45.3 |
1 |
10446136 (1) |
| nadph |
20.5 |
3 |
15089095 (2), 15547247 (1) |
Search CenterWatch for drugs/clinical trials and news about NPTXR 
|
Transcripts for NPTXR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NPTXR gene (2 alternative transcripts): NM_014293.3 NM_058178.1 Unigene Cluster for NPTXR: Neuronal pentraxin receptor Hs.91622 [show with all ESTs]Unigene Representative Sequence: NM_0142931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333039(uc003awk.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPTXR (NM_014293) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPTXR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTXR  |
Additional cDNA sequence: AF052163.1 AL161974.1 AL162057.1 BC043606.1 6 DOTS entries: DT.100781229 DT.448345 DT.100781231 DT.120650937 DT.433700 DT.91909871 24/212 AceView cDNA sequences (see all 212): CD635635 AI014314 CD635634 D52028 CB152312 T33852 BM664678 AW963649 AA372919 R88792 AL118608 BU632940 D51955 BM722090 BE048263 AA322700 H41734 BU856929 BC043606 BX090839 T30973 NM_058178 AF052163 NM_014293 GeneLoc Exon Structure
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Expression for NPTXR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPTXR expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTGTTTAAAA
 About this image See NPTXR Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NPTXR
SOURCE GeneReport for Unigene cluster: Hs.91622 SABiosciences Custom PCR Arrays for NPTXR
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPTXR Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NPTXR | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTXR | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTXR | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR |
Orthologs for NPTXR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NPTXR gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
NPTXR6 |
Uncharacterized protein |
61(a) |
1 ↔ 1 |
1(52712594-52718221) |
zebrafish (Danio rerio) |
Actinopterygii |
nptxrb1 |
neuronal pentraxin receptor b |
56.61(n) 50(a) |
  |
100005257 NM_001044314.1 NP_001037779.1 |
ENSEMBL Gene Tree for NPTXR (if available) TreeFam Gene Tree for NPTXR (if available)  |
Paralogs for NPTXR gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NPTXR gene
- NPTX22 APCS2 CBX62 CRP2 PTX42 NPTX12 PTX32
2 SIMAP similar genes for NPTXR using alignment to 1 protein entry: NPTXR_HUMAN:NPTX2 NPTX1
NPTXR for paralogs About GeneDecksing
|
Genomic Variants for NPTXR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 22 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NPTXR (39214457 - 39240017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NPTXR: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPTXR |
|
Disorders
/ Diseases for NPTXR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPTXR for disorders About GeneDecksing
OMIM gene information: 609474
OMIM disorders: --
12 diseases for NPTXR: About MalaCardsneuronitis acromesomelic dysplasia congestive heart failure neurodegenerative disease aldosteronism pneumonia cardiomyopathy lung cancer adenoma obesity hypertension hepatitis Human Genome Epidemiology (HuGE) Navigator: NPTXR (1 document) Export disorders for NPTXR gene to outside databases
|
Publications for NPTXR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPTXR gene, integrated from 9 sources (see all 34): (articles sorted by number of sources associating them with NPTXR) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Regulation of neuronal type genes in congestive heart failure rats. (PubMed id 16497176)1, 3 Andersson K.B....Christensen G. (2006)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (1997)
- Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. (PubMed id 19368810)1, 9 Yin G.N....Suk K. (2009)
- Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1 Kirkpatrick L.L....Perin M.S. (2000)
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External Searches for NPTXR gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NPTXR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPTXR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPTXR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NPTXR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPTXR gene: Search GeneIP for patents involving NPTXR
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NPTXR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for NPTXR | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPTXR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPTXR | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for NPTXR | | OriGene 3'-UTR Clone for NPTXR | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTXR | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | NPTXR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR |
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