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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPTXR Gene

protein-coding   GIFtS: 51
GCID: GC22M039214

neuronal pentraxin receptor

 Explore 12 diseases affiliated with
NPTXR via our new
 Human Malady Compendium 
Biological research products
for NPTXR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neuronal Pentraxin Receptor1 2
NPR2

External Ids:    HGNC: 79541   Entrez Gene: 234672   Ensembl: ENSG000002218907   OMIM: 6094745   UniProtKB: O955023   

Export aliases for NPTXR gene to outside databases

Previous GC identifers: GC22M035828 GC22M037457 GC22M037538 GC22M022180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPTXR:
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral
membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into
the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also
be true for mouse and human, based on strong sequence conservation amongst these species. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502
Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

Gene Wiki entry for NPTXR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPTXR gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   Lmo2   AP-4   Evi-1   Meis-1b   HOXA5   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPTXR promoter sequence
   Search SABiosciences Chromatin IP Primers for NPTXR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTXR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

NPTXR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTXR gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039214:  view genomic region     (about GC identifiers)

Start:
39,214,457 bp from pter      End:
39,240,017 bp from pter
Size:
25,561 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502 (See protein sequence)
Recommended Name: Neuronal pentraxin receptor  
Size: 500 amino acids; 52846 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49
(TCBP49/RCN2) (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=CAA15430.3; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for NPTXR: NX_O95502

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95502

  • NPTXR Protein expression data from MOPED and PaxDb:    About this image 
    NPTXR Protein Expression
    REFSEQ proteins: NP_055108.2  
    ENSEMBL proteins: 
     ENSP00000327545  

    Human Recombinant Protein Products for NPTXR: 
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    Uscn Proteins for NPTXR

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ----
    GO:0005886plasma membrane ----
    GO:0016021integral to membrane IEA--

    NPTXR for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NPTXR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NPTXR for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry O95502

    ProtoNet protein and cluster: O95502

    1 Blocks protein family: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502
    Similarity: Contains 1 pentaxin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPTXR_HUMAN, O95502
    Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
    synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

         Genatlas biochemistry entry for NPTXR:
    neuronal pentraxin receptor,interacting with NPTX1,NPTX2 and taipoxin-associated calcium binding protein 49,putatively
    involved in the clearance of synaptic debris

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008029pentraxin receptor activity ----
    GO:0032403protein complex binding ----
    GO:0046872metal ion binding IEA--
         
    NPTXR for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nptxr):
     nervous system 

    NPTXR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Nptxrtm1Mspn for NPTXR
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NPTXR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPTXR

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NPTXR (O955023 ENSP000003275454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPTX2P479723, ENSP000002656344I2D: score=1 STRING: ENSP00000265634
    NPTX1Q158183, ENSP000003075494I2D: score=1 STRING: ENSP00000307549
    GBASO753233I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042542response to hydrogen peroxide ----

    NPTXR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPTXR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPTXR

    1 HMDB Compound for NPTXR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    2 Novoseek chemical compound relationships for NPTXR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 45.3 1 10446136 (1)
    nadph 20.5 3 15089095 (2), 15547247 (1)

    Search CenterWatch for drugs/clinical trials and news about NPTXR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPTXR gene (2 alternative transcripts): 
    NM_014293.3  NM_058178.1  

    Unigene Cluster for NPTXR:

    Neuronal pentraxin receptor
    Hs.91622  [show with all ESTs]
    Unigene Representative Sequence: NM_014293
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333039(uc003awk.3)

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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTXR (see all 46):
    hsa-miR-128 hsa-miR-30d hsa-miR-4314 hsa-miR-30a hsa-miR-149 hsa-miR-330-3p hsa-miR-761 hsa-miR-3144-5p
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    OriGene shRNA RFP: NPTXR
    OriGene siRNA: NPTXR
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTXR
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    Additional cDNA sequence: 

    AF052163.1 AL161974.1 AL162057.1 BC043606.1 

    6 DOTS entries:

    DT.100781229  DT.448345  DT.100781231  DT.120650937  DT.433700  DT.91909871 

    24/212 AceView cDNA sequences (see all 212):

    CD635635 AI014314 CD635634 D52028 CB152312 T33852 BM664678 AW963649 
    AA372919 R88792 AL118608 BU632940 D51955 BM722090 BE048263 AA322700 
    H41734 BU856929 BC043606 BX090839 T30973 NM_058178 AF052163 NM_014293 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPTXR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTTTAAAA
    NPTXR Expression
    About this image
    See NPTXR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPTXR

    SOURCE GeneReport for Unigene cluster: Hs.91622
        SABiosciences Custom PCR Arrays for NPTXR

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NPTXR gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NPTXR6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(52712594-52718221)
    zebrafish
    (Danio rerio)
    Actinopterygii nptxrb1 neuronal pentraxin receptor b 56.61(n)
    50(a)
      100005257  NM_001044314.1  NP_001037779.1 


    ENSEMBL Gene Tree for NPTXR (if available)
    TreeFam Gene Tree for NPTXR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPTXR gene
    NPTX22  APCS2  CBX62  CRP2  PTX42  NPTX12  PTX32  
    2 SIMAP similar genes for NPTXR using alignment to 1 protein entry:     NPTXR_HUMAN:
    NPTX2    NPTX1

    NPTXR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/468 NCBI SNPs in NPTXR are shown (see all 468    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452318761,2
    Cother39222748(+) GCTGAG/AGACCC 2 /S syn11Minor allele frequency- A:0.00NA 4546
    rs1430191451,2
    --39213965(+) GTCTAC/GAGGCC 1 -- ds50010--------
    rs57506831,2
    C,F,A,H--39214146(+) ATCCCA/TGAACT 1 -- ds500125Minor allele frequency- T:0.12NS EA NA WA CSA 2343
    rs1433429161,2
    --39214162(+) ACAAGA/TTGTGG 1 -- ds50010--------
    rs57506841,2
    C,H--39214208(+) CAGAAC/TTGGGA 1 -- ds50012Minor allele frequency- T:0.01NS NA 182
    rs1483430171,2
    --39214225(+) CCATGC/TGGGAC 1 -- ds50010--------
    rs1846482421,2
    --39214261(+) TAAATC/TCTGGG 1 -- ds50010--------
    rs1388929901,2
    --39214543(+) CACAT-/ACACACA 1 -- ut310--------
    rs1903646561,2
    --39214561(+) CACGCA/GCACAC 1 -- ut310--------
    rs1412109821,2
    --39214583(+) TTGCAG/TCTCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NPTXR (39214457 - 39240017 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPTXR: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NPTXR for disorders           About GeneDecksing

    OMIM gene information: 609474    OMIM disorders: --

    12 diseases for NPTXR:    About MalaCards
    neuronitis    acromesomelic dysplasia    congestive heart failure    neurodegenerative disease
    aldosteronism    pneumonia    cardiomyopathy    lung cancer
    adenoma    obesity    hypertension    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: NPTXR (1 document)

    Export disorders for NPTXR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPTXR gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with NPTXR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of neuronal type genes in congestive heart failure rats. (PubMed id 16497176)1, 3 Andersson K.B....Christensen G. (2006)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    3. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (1997)
    4. Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. (PubMed id 19368810)1, 9 Yin G.N....Suk K. (2009)
    5. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1 Kirkpatrick L.L....Perin M.S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23467 HGNC: 7954 AceView: NPTXR Ensembl:ENSG00000221890 euGenes: HUgn23467
    ECgene: NPTXR H-InvDB: NPTXR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPTXR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPTXR gene:
    Search GeneIP for patents involving NPTXR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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