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Aliases for NPTXR Gene

Aliases for NPTXR Gene

  • Neuronal Pentraxin Receptor 2 3
  • NPR 3

External Ids for NPTXR Gene

Previous GeneCards Identifiers for NPTXR Gene

  • GC22M035828
  • GC22M037457
  • GC22M037538
  • GC22M039214
  • GC22M022180

Summaries for NPTXR Gene

Entrez Gene Summary for NPTXR Gene

  • This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPTXR Gene

NPTXR (Neuronal Pentraxin Receptor) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for NPTXR Gene

  • May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

Gene Wiki entry for NPTXR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPTXR Gene

Genomics for NPTXR Gene

Regulatory Elements for NPTXR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPTXR Gene

38,818,451 bp from pter
38,844,012 bp from pter
25,562 bases
Minus strand

Genomic View for NPTXR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPTXR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPTXR Gene

Proteins for NPTXR Gene

  • Protein details for NPTXR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal pentraxin receptor
    Protein Accession:
    Secondary Accessions:

    Protein attributes for NPTXR Gene

    500 amino acids
    Molecular mass:
    52846 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    • Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 (By similarity).
    • Sequence=CAA15430.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPTXR Gene

Proteomics data for NPTXR Gene at MOPED

Post-translational modifications for NPTXR Gene

  • Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.
  • Glycosylation at Asn42, Asn216, and Asn463
  • Modification sites at PhosphoSitePlus

Other Protein References for NPTXR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NPTXR (Neuronal Pentraxin R/NPTXR)

No data available for DME Specific Peptides for NPTXR Gene

Domains for NPTXR Gene

Protein Domains for NPTXR Gene


Suggested Antigen Peptide Sequences for NPTXR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 pentaxin domain.
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with NPTXR: view

No data available for Gene Families for NPTXR Gene

Function for NPTXR Gene

Molecular function for NPTXR Gene

GENATLAS Biochemistry:
neuronal pentraxin receptor,interacting with NPTX1,NPTX2 and taipoxin-associated calcium binding protein 49,putatively involved in the clearance of synaptic debris
UniProtKB/Swiss-Prot Function:
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

Gene Ontology (GO) - Molecular Function for NPTXR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NPTXR: view

Phenotypes for NPTXR Gene

MGI mutant phenotypes for NPTXR:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPTXR: view

Animal Models for NPTXR Gene

MGI Knock Outs for NPTXR:

Animal Model Products

CRISPR Products

miRNA for NPTXR Gene

miRTarBase miRNAs that target NPTXR

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPTXR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPTXR Gene

Localization for NPTXR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPTXR Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for NPTXR Gene COMPARTMENTS Subcellular localization image for NPTXR gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NPTXR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPTXR: view

Pathways for NPTXR Gene

genes like me logo Genes that share pathways with NPTXR: view

Pathways by source for NPTXR Gene

Interacting Proteins for NPTXR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327545 O95502-NPTXR_HUMAN for NPTXR Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NPTXR Gene


Drugs for NPTXR Gene

(12) Drugbank Compounds for NPTXR Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Flavin adenine dinucleotide
  • Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine
146-14-5 643975 Target approved
5287837 Target experimental
5289469 Target experimental
5287517 Target experimental
5288636 Target experimental

(1) HMDB Compounds for NPTXR Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for NPTXR Gene

Compound -log(P) Hits PubMed IDs
cgmp 45.3 1
nadph 20.5 3
genes like me logo Genes that share compounds with NPTXR: view

Transcripts for NPTXR Gene

mRNA/cDNA for NPTXR Gene

(212) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPTXR Gene

Neuronal pentraxin receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPTXR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPTXR Gene

No ASD Table

Relevant External Links for NPTXR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPTXR Gene

mRNA expression in normal human tissues for NPTXR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPTXR Gene

This gene is overexpressed in Brain - Hippocampus (8.6), Brain - Anterior cingulate cortex (BA24) (6.5), Brain - Cortex (6.0), Brain - Amygdala (6.0), and Brain - Frontal Cortex (BA9) (5.2).

Protein differential expression in normal tissues for NPTXR Gene

This gene is overexpressed in Cerebrospinal fluid (62.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NPTXR Gene

SOURCE GeneReport for Unigene cluster for NPTXR Gene Hs.91622

genes like me logo Genes that share expressions with NPTXR: view

Expression partners for NPTXR Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NPTXR Gene

Orthologs for NPTXR Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPTXR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPTXR 35
  • 91.13 (n)
  • 94.3 (a)
  • 94 (a)
(Mus musculus)
Mammalia Nptxr 35
  • 88.03 (n)
  • 90.47 (a)
Nptxr 16
Npcd 36
  • 59 (a)
Nptxr 36
  • 89 (a)
(Pan troglodytes)
Mammalia NPTXR 35
  • 95.34 (n)
  • 94.33 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Nptxr 35
  • 87.85 (n)
  • 90.49 (a)
(Canis familiaris)
Mammalia NPTXR 36
  • 47 (a)
(Monodelphis domestica)
Mammalia NPTXR 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia NPTXR 36
  • 48 (a)
(Gallus gallus)
Aves NPTXR 36
  • 36 (a)
(Anolis carolinensis)
Reptilia NPTXR 36
  • 33 (a)
(Danio rerio)
Actinopterygii nptxrb 35
  • 55.26 (n)
  • 48.36 (a)
nptxra 36
  • 23 (a)
nptxrb 36
  • 31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3519 35
Species with no ortholog for NPTXR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPTXR Gene

Gene Tree for NPTXR (if available)
Gene Tree for NPTXR (if available)

Paralogs for NPTXR Gene

Paralogs for NPTXR Gene

(2) SIMAP similar genes for NPTXR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPTXR: view

Variants for NPTXR Gene

Sequence variations from dbSNP and Humsavar for NPTXR Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs186467481 -- 38,836,964(+) TGCCC(A/G)CCACC intron-variant
rs186293581 -- 38,819,457(+) GGGGT(C/T)GGAAC utr-variant-3-prime
rs186261186 -- 38,823,552(+) GGATG(G/T)CTCAT intron-variant
rs186070037 -- 38,828,783(+) TGGGG(C/T)GTGGC intron-variant
rs185976827 -- 38,822,526(+) AGTGC(A/G)TGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPTXR Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
nsv471199 CNV Loss 18288195
nsv915069 CNV Loss 21882294
nsv915070 CNV Loss 21882294
esv2724233 CNV Deletion 23290073
esv2724234 CNV Deletion 23290073
nsv915071 CNV Loss 21882294

Relevant External Links for NPTXR Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPTXR Gene

Disorders for NPTXR Gene

Relevant External Links for NPTXR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NPTXR Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NPTXR Gene

Publications for NPTXR Gene

  1. Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. (PMID: 19368810) Yin G.N. … Suk K. (Brain Res. 2009) 3 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Regulation of neuronal type genes in congestive heart failure rats. (PMID: 16497176) Andersson K.B. … Christensen G. (Acta Physiol (Oxf) 2006) 2 3
  4. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PMID: 16115696) Poulsen T.T. … Poulsen H.S. (Lung Cancer 2005) 3 23
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for NPTXR Gene

Sources for NPTXR Gene

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