Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPTXR Gene

protein-coding   GIFtS: 53
GCID: GC22M039214

Neuronal Pentraxin Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuronal Pentraxin Receptor1 2
NPR2

External Ids:    HGNC: 79541   Entrez Gene: 234672   Ensembl: ENSG000002218907   OMIM: 6094745   UniProtKB: O955023   

Export aliases for NPTXR gene to outside databases

Previous GC identifers: GC22M035828 GC22M037457 GC22M037538 GC22M022180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPTXR Gene:
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an
integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its
transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG)
codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NPTXR Gene: 
NPTXR (neuronal pentraxin receptor) is a protein-coding gene. Diseases associated with NPTXR include acromesomelic dysplasia, and congestive heart failure. GO annotations related to this gene include metal ion binding. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502
Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

Gene Wiki entry for NPTXR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPTXR gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   Lmo2   AP-4   Evi-1   Meis-1b   HOXA5   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPTXR promoter sequence
   Search SABiosciences Chromatin IP Primers for NPTXR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTXR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

NPTXR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTXR gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039214:  view genomic region     (about GC identifiers)

Start:
39,214,456 bp from pter      End:
39,240,017 bp from pter
Size:
25,562 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502 (See protein sequence)
Recommended Name: Neuronal pentraxin receptor  
Size: 500 amino acids; 52846 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49
(TCBP49/RCN2). Interacts with KLHL2 (By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=CAA15430.3; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for NPTXR: NX_O95502

Explore proteomics data for NPTXR at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2 (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95502

  • NPTXR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPTXR Protein Expression
    REFSEQ proteins: NP_055108.2  
    ENSEMBL proteins: 
     ENSP00000327545  

    Human Recombinant Protein Products for NPTXR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NPTXR (Neuronal Pentraxin R/NPTXR)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPTXR
    GenScript Custom Purified and Recombinant Proteins Services for NPTXR
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPTXR 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    NPTXR for ontologies           About GeneDecksing



    NPTXR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NPTXR
    R&D Systems Antibodies for NPTXR (Neuronal Pentraxin R/NPTXR)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NPTXR
    GenScript Custom Superior Antibodies Services for NPTXR
    Novus Biologicals NPTXR Antibodies
    Abcam antibodies for NPTXR
    Cloud-Clone Corp. Antibodies for NPTXR 
    Search ThermoFisher Antibodies for NPTXR
    LSBio Antibodies in human, mouse, rat for NPTXR 

    Assay Products for NPTXR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPTXR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPTXR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPTXR 
    Cloud-Clone Corp. CLIAs for NPTXR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry O95502

    ProtoNet protein and cluster: O95502

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTXR_HUMAN, O95502
    Similarity: Contains 1 pentaxin domain


    NPTXR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPTXR_HUMAN, O95502
    Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
    synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

         Genatlas biochemistry entry for NPTXR:
    neuronal pentraxin receptor,interacting with NPTX1,NPTX2 and taipoxin-associated calcium binding protein
    49,putatively involved in the clearance of synaptic debris

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    NPTXR for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nptxr):
     nervous system 

    NPTXR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nptxrtm1Mspn for NPTXR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPTXR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPTXR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPTXR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPTXR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTXR
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTXR (see all 46):
    hsa-miR-128 hsa-miR-30d hsa-miR-4314 hsa-miR-30a hsa-miR-149 hsa-miR-330-3p hsa-miR-761 hsa-miR-3144-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPTXR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTXR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPTXR
    Sirion Biotech Customized adenovirus for overexpression of NPTXR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NPTXR (see all 5)
    OriGene ORF clones in mouse, rat for NPTXR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPTXR (NM_014293)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTXR
    Sirion Biotech Customized lentivirus for stable overexpression of NPTXR 
                         Customized lentivirus expression plasmids for stable overexpression of NPTXR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPTXR
    Search LifeMap BioReagents cell lines for NPTXR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPTXR

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NPTXR (O955023 ENSP000003275454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPTX2P479723, ENSP000002656344I2D: score=1 STRING: ENSP00000265634
    NPTX1Q158183, ENSP000003075494I2D: score=1 STRING: ENSP00000307549
    GBASO753233I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPTXR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPTXR

    1 HMDB Compound for NPTXR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for NPTXR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 45.3 1 10446136 (1)
    nadph 20.5 3 15089095 (2), 15547247 (1)

    Search CenterWatch for drugs/clinical trials and news about NPTXR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPTXR gene (2 alternative transcripts): 
    NM_014293.3  NM_058178.1  

    Unigene Cluster for NPTXR:

    Neuronal pentraxin receptor
    Hs.91622  [show with all ESTs]
    Unigene Representative Sequence: NM_014293
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333039(uc003awk.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTXR
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTXR (see all 46):
    hsa-miR-128 hsa-miR-30d hsa-miR-4314 hsa-miR-30a hsa-miR-149 hsa-miR-330-3p hsa-miR-761 hsa-miR-3144-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPTXR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTXR
    Clone
    Products:
         
    OriGene clones in human, mouse for NPTXR (see all 5)
    OriGene ORF clones in mouse, rat for NPTXR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPTXR (NM_014293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTXR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTXR
    Sirion Biotech Customized lentivirus for stable overexpression of NPTXR 
                         Customized lentivirus expression plasmids for stable overexpression of NPTXR 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NPTXR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NPTXR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTXR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTXR

    Additional mRNA sequence: 

    AF052163.1 AL161974.1 AL162057.1 BC043606.1 

    6 DOTS entries:

    DT.100781229  DT.448345  DT.100781231  DT.120650937  DT.433700  DT.91909871 

    24/212 AceView cDNA sequences (see all 212):

    D51955 BU632940 AI014314 BQ230962 BM664678 H41734 AL118608 AW963649 
    BC043606 T33852 BU856929 AF052163 R88792 AA372919 CB152312 BX090839 
    NM_058178 T30973 BE048263 AA322700 CD635635 D52028 BM722090 CD635634 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPTXR expression in normal human tissues (normalized intensities)      NPTXR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTAAAA
    NPTXR Expression
    About this image


    NPTXR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Amygdala
             prefrontal cortex   
     
     Testis (Reproductive System)

    See NPTXR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPTXR

    SOURCE GeneReport for Unigene cluster: Hs.91622
        SABiosciences Custom PCR Arrays for NPTXR
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NPTXR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NPTXR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTXR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTXR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NPTXR gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nptxr1 , 5 neuronal pentraxin receptor1, 5 88.03(n)1
    90.47(a)1
      15 (37.85 cM)5
    733401  NM_030689.41  NP_109614.21 
     797863535 
    chicken
    (Gallus gallus)
    Aves NPTXR6
    Uncharacterized protein
    33(a)
    possible ortholog
    1(50627427-50649375)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    31(a)
    possible ortholog
    5(24307274-24385885)
    zebrafish
    (Danio rerio)
    Actinopterygii nptxrb1 neuronal pentraxin receptor b 56.61(n)
    50(a)
      100005257  NM_001044314.1  NP_001037779.1 


    ENSEMBL Gene Tree for NPTXR (if available)
    TreeFam Gene Tree for NPTXR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPTXR gene
    NPTX22  APCS2  CRP2  PTX42  NPTX12  PTX32  
    2 SIMAP similar genes for NPTXR using alignment to 1 protein entry:     NPTXR_HUMAN:
    NPTX2    NPTX1

    NPTXR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/974 SNPs in NPTXR are shown (see all 974)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452318761,2
    Cuntested139222748(+) GCTGAG/AGACCC 2 /S syn11Minor allele frequency- A:0.00NA 4546
    rs1169421611,2
    C,F--22206071(+) GTCCAA/GGGTCA 1 -- int11Minor allele frequency- G:0.07EA 120
    rs126284731,2
    C,H--22206303(+) TCATTA/GCAGAA 1 -- int12Minor allele frequency- G:0.11CSA EA 122
    rs126284971,2
    C,A,H--22206306(+) TTACAG/AAATCT 1 -- int13Minor allele frequency- A:0.07CSA WA EA 240
    rs1812311801,2
    --22206349(+) TCCTCC/TGAATC 1 -- int10--------
    rs1870949341,2
    --22206387(+) AGAGAA/TACCCC 1 -- int10--------
    rs119133541,2
    C,F,H--22206413(+) TCTGCC/TTTCGT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1461090221,2
    --22206589(+) TAAAAA/GCAATC 1 -- int10--------
    rs1906299101,2
    C--22206639(+) ATGAGA/GTCTTT 1 -- int10--------
    rs1835436111,2
    --22206657(+) AATACA/GGATTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NPTXR (39214456 - 39240017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NPTXR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724234CNV Deletion23290073
    esv2724233CNV Deletion23290073
    nsv915071CNV Loss21882294
    nsv915070CNV Loss21882294
    nsv915069CNV Loss21882294
    nsv471199CNV Loss18288195
    nsv915068CNV Loss21882294
    nsv915067CNV Loss21882294
    dgv769n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPTXR
    DNA2.0 Custom Variant and Variant Library Synthesis for NPTXR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609474    OMIM disorders: --

    8 diseases for NPTXR:    About MalaCards
    acromesomelic dysplasia    congestive heart failure    neuronitis    obesity
    adenoma    hypertension    lung cancer    hepatitis


    NPTXR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NPTXR
    Human Genome Epidemiology (HuGE) Navigator: NPTXR (1 document)

    Export disorders for NPTXR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPTXR gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with NPTXR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Regulation of neuronal type genes in congestive heart failure rats. (PubMed id 16497176)1, 3 Andersson K.B....Christensen G. (2006)
    3. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    4. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (1997)
    5. Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. (PubMed id 19368810)1, 9 Yin G.N....Suk K. (2009)
    6. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1 Kirkpatrick L.L....Perin M.S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23467 HGNC: 7954 AceView: NPTXR Ensembl:ENSG00000221890 euGenes: HUgn23467
    ECgene: NPTXR H-InvDB: NPTXR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPTXR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPTXR gene:
    Search GeneIP for patents involving NPTXR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NPTXR
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NPTXR (Neuronal Pentraxin R/NPTXR)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for NPTXR (Neuronal Pentraxin R/NPTXR)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NPTXR  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPTXR  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPTXR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPTXR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPTXR   OriGene Custom Protein Services for NPTXR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPTXR
     QIAGEN SeqTarget long-range PCR primers for resequencing NPTXR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTXR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTXR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTXR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTXR
     GenScript Custom Purified and Recombinant Proteins Services for NPTXR GenScript cDNA clones with any tag delivered in your preferred vector for NPTXR
     GenScript Custom Assay Services for NPTXR GenScript Custom Superior Antibodies Services for NPTXR
     GenScript Custom overexpressing Cell Line Services for NPTXR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NPTXR promoter
     Search Chromatin IP Primers for NPTXR
     RT2 qPCR Primer Assay in human, mouse / rat NPTXR
     Search GNC Networks for NPTXR
     SABiosciences Custom PCR Arrays for NPTXR
     Search Tocris compounds for NPTXR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPTXR antibodies
     Antibodies for NPTXR
     See all of Abcam's Antibodies, Kits and Proteins for NPTXR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NPTXR
     Antibodies for NPTXR
     ELISAs for NPTXR
     CLIAs for NPTXR
     Search LifeMap BioReagents cell lines for NPTXR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTXR
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NPTXR
     SwitchGear Promoter luciferase reporter plasmids for NPTXR
     Search ThermoFisher Antibodies for NPTXR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTXR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPTXR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPTXR
    Customized:
     lentivirus for stable overexpression of NPTXR
     lentivirus expression plasmids for stable overexpression of NPTXR
     adenovirus for overexpression of NPTXR
     LSBio Antibodies in human, mouse, rat for NPTXR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPTXR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4