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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPTX2 Gene

protein-coding   GIFtS: 57
GCID: GC07P098246

Neuronal Pentraxin II

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuronal Pentraxin II1 2 3     NARP2
apexin1 2     Neuronal Activity-Regulated Pentaxin2
NP-II2 3     Neuronal Pentraxin-22
NP22 3     

External Ids:    HGNC: 79531   Entrez Gene: 48852   Ensembl: ENSG000001062367   OMIM: 6007505   UniProtKB: P479723   

Export aliases for NPTX2 gene to outside databases

Previous GC identifers: GC07P096781 GC07P097844 GC07P097858 GC07P097891 GC07P098084 GC07P092845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPTX2 Gene:
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive
protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses,
resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson
disease (PD) tissues suggests that the protein may be involved in the pathology of PD. (provided by RefSeq, Feb
2009)

GeneCards Summary for NPTX2 Gene: 
NPTX2 (neuronal pentraxin II) is a protein-coding gene. Diseases associated with NPTX2 include neurohypophyseal diabetes insipidus, and neuronitis. GO annotations related to this gene include molecular_function and metal ion binding. An important paralog of this gene is APCS.

UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds
to agar matrix in a calcium-dependent manner (By similarity)

Gene Wiki entry for NPTX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPTX2 gene promoter:
         NRSF form 1   MyoD   POU3F2 (N-Oct-5b)   Nkx2-5   NRSF form 2   C/EBPalpha   IRF-2   S8   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPTX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPTX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

NPTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098246:  view genomic region     (about GC identifiers)

Start:
98,246,597 bp from pter      End:
98,259,181 bp from pter
Size:
12,585 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 97,570,995-97,583,579     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972 (See protein sequence)
Recommended Name: Neuronal pentraxin-2 precursor  
Size: 431 amino acids; 47042 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR)
Subcellular location: Secreted (By similarity)
Secondary accessions: A4D267 Q86XV7 Q96G70

Explore the universe of human proteins at neXtProt for NPTX2: NX_P47972

Explore proteomics data for NPTX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47972

  • NPTX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPTX2 Protein Expression
    REFSEQ proteins: NP_002514.1  
    ENSEMBL proteins: 
     ENSP00000265634  

    Human Recombinant Protein Products for NPTX2: 
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    Novus Biologicals NPTX2 Proteins
    Novus Biologicals NPTX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPTX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    NPTX2 for ontologies           About GeneDecksing



    NPTX2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for NPTX2 
    Cloud-Clone Corp. CLIAs for NPTX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P47972

    ProtoNet protein and cluster: P47972

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Similarity: Contains 1 pentaxin domain


    NPTX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPTX2_HUMAN, P47972
    Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds
    to agar matrix in a calcium-dependent manner (By similarity)

         Genatlas biochemistry entry for NPTX2:
    pentaxin (pentraxin) 2,expressed in brain and other tissues,mediating the uptake of synaptic material and
    presynaptic toxins

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0046872metal ion binding IEA--
         
    NPTX2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nptx2):
     behavior/neurological  nervous system  vision/eye 

    NPTX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NPTX2: Nptx2tm1Awj Nptx2tm1Mspn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPTX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPTX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPTX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPTX2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTX2
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNPTX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NPTX2

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of NPTX2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPTX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NPTX2 (P479723 ENSP000002656344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NPTXRO955023, ENSP000003275454I2D: score=1 STRING: ENSP00000327545
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission NAS8530029

    NPTX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPTX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPTX2

    1 HMDB Compound for NPTX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for NPTX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 20.5 3 20212045 (2), 12196584 (1)

    Search CenterWatch for drugs/clinical trials and news about NPTX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPTX2 gene: 
    NM_002523.2  

    Unigene Cluster for NPTX2:

    Neuronal pentraxin II
    Hs.3281  [show with all ESTs]
    Unigene Representative Sequence: BC048275
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265634(uc003upl.2) ENST00000466102

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNPTX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTX2
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTX2
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                         Customized lentivirus expression plasmids for stable overexpression of NPTX2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTX2

    Additional mRNA sequence: 

    AK311250.1 BC009924.2 BC034781.1 BC035339.1 BC048275.1 U26662.1 

    3 DOTS entries:

    DT.113314  DT.92388407  DT.113315 

    24/94 AceView cDNA sequences (see all 94):

    NM_002523 CA848611 BX117099 BC048275 BM926764 BQ286410 AA628155 T32853 
    BC034781 BC009924 BM697956 CD512988 BI438484 BM893865 AI570405 CD513689 
    F12910 BG654715 Z39297 AA970298 BQ109438 BF940129 BI489921 AL042877 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPTX2 expression in normal human tissues (normalized intensities)      NPTX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCATCCTGA
    NPTX2 Expression
    About this image


    NPTX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Human Cerebellar Astrocytes   
             Septum   
     
     Fibroblast
             Human Villous Mesenchymal Fibroblasts (HVMF)   
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Zeugopod Periosteum
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Dermis (Uncategorized)    fully expand to see all 4 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Human Skeletal Muscle Myoblast (HSkMM)   

    See NPTX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPTX2

    SOURCE GeneReport for Unigene cluster: Hs.3281

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Tissue specificity: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis

        SABiosciences Expression via Pathway-Focused PCR Array including NPTX2: 
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NPTX2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nptx21 , 5 neuronal pentraxin 21, 5 89.02(n)1
    96.96(a)1
      5 (84.58 cM)5
    533241  NM_016789.31  NP_058069.11 
     1445458875 
    chicken
    (Gallus gallus)
    Aves NPTX21 neuronal pentraxin II 76.13(n)
    84.51(a)
      416438  XM_414750.3  XP_414750.3 
    lizard
    (Anolis carolinensis)
    Reptilia NPTX26
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343385.1(994531-1005868)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187552 Transcribed sequence with weak similarity to protein more 70.97(n)    CF996857.1 


    ENSEMBL Gene Tree for NPTX2 (if available)
    TreeFam Gene Tree for NPTX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPTX2 gene
    APCS2  CRP2  PTX42  NPTX12  NPTXR2  PTX32  
    2 SIMAP similar genes for NPTX2 using alignment to 1 protein entry:     NPTX2_HUMAN:
    NPTX1    NPTXR

    NPTX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/298 SNPs in NPTX2 are shown (see all 298)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457924641,2
    C--97572279(+) TCTCT-/CCCCCC 1 -- int10--------
    rs1847535551,2
    --97572287(+) CCCCCC/TCCCCC 1 -- int10--------
    rs30639211,2
    C--98256084(+) ACAGA-/ACA   
      G
    /CAGA
    TCCCT
    1 -- int10--------
    rs1922750461,2
    C--101548116(+) GTTTAA/CTTATT 1 -- us2k10--------
    rs1840074421,2
    --101548146(+) TCAAGC/TAGTTG 1 -- us2k10--------
    rs3866891,2
    H--101548249(+) ACCTAG/TGTCTA 1 -- us2k15Minor allele frequency- T:0.00MN NS EA 598
    rs1378907921,2
    --101548283(+) TATGAA/GTGAAA 1 -- us2k10--------
    rs1494946731,2
    --101548317(+) GAATAA/GTTTTG 1 -- us2k10--------
    rs1181111411,2
    C,F--101548328(+) AAAACG/TTCTGG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs750511651,2
    C,F--101548406(+) ATTATT/GGTAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for NPTX2 (98246597 - 98259181 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPTX2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPTX2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPTX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600750    OMIM disorders: --

    20/21 diseases for NPTX2 (see all 21):    About MalaCards
    neurohypophyseal diabetes insipidus    neuronitis    pearson syndrome    kearns-sayre syndrome
    diabetes insipidus    narcolepsy    encephalomyopathy    mitochondrial encephalomyopathy
    autism spectrum disorder    parkinson's disease    lactic acidosis    malignant glioma
    endometriosis    mood disorder    infertility    pancreatic cancer
    mental retardation    neuropathy    lung cancer    pancreatitis

    9 diseases from the University of Copenhagen DISEASES database for NPTX2:
    Retinitis pigmentosa     Leigh disease     Kearns-Sayre syndrome     Neurohypophyseal diabetes insipidus
    Mitochondrial encephalomyopathy     Neuropathy     Pearson syndrome     Visual pathway disease
    Lactic acidosis

    NPTX2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NPTX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 60.1 3 16135770 (2), 16247044 (1)

    Genetic Association Database (GAD): NPTX2
    Human Genome Epidemiology (HuGE) Navigator: NPTX2 (3 documents)

    Export disorders for NPTX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPTX2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with NPTX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. (PubMed id 8530029)1, 2, 3, 9 Hsu Y.-C. and Perin M.S. (1995)
    2. No association between the neuronal pentraxin II gene polymorphism and autism. (PubMed id 17408830)1, 4, 9 Marui T....Sasaki T. (2007)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1, 2 Kirkpatrick L.L....Perin M.S. (2000)
    8. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. (PubMed id 17987278)1, 9 Moran L.B....Graeber M.B. (2008)
    9. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (1997)
    10. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4885 HGNC: 7953 AceView: NPTX2 Ensembl:ENSG00000106236 euGenes: HUgn4885
    ECgene: NPTX2 H-InvDB: NPTX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPTX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPTX2 gene:
    Search GeneIP for patents involving NPTX2

    GeneCards and IP:
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