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Aliases for NPTX2 Gene

Aliases for NPTX2 Gene

  • Neuronal Pentraxin II 2 3 4
  • Apexin 2 3
  • NP-II 3 4
  • NP2 3 4
  • Neuronal Activity-Regulated Pentaxin 3
  • NARP 3

External Ids for NPTX2 Gene

Previous GeneCards Identifiers for NPTX2 Gene

  • GC07P096781
  • GC07P097844
  • GC07P097858
  • GC07P097891
  • GC07P098084
  • GC07P098246
  • GC07P092845

Summaries for NPTX2 Gene

Entrez Gene Summary for NPTX2 Gene

  • This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

GeneCards Summary for NPTX2 Gene

NPTX2 (Neuronal Pentraxin II) is a Protein Coding gene. Diseases associated with NPTX2 include narcolepsy and melas syndrome. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for NPTX2 Gene

  • Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).

Gene Wiki entry for NPTX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPTX2 Gene

Genomics for NPTX2 Gene

Regulatory Elements for NPTX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPTX2 Gene

Chromosome:
7
Start:
98,617,285 bp from pter
End:
98,629,869 bp from pter
Size:
12,585 bases
Orientation:
Plus strand

Genomic View for NPTX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPTX2 Gene

Proteins for NPTX2 Gene

  • Protein details for NPTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47972-NPTX2_HUMAN
    Recommended name:
    Neuronal pentraxin-2
    Protein Accession:
    P47972
    Secondary Accessions:
    • A4D267
    • Q86XV7
    • Q96G70

    Protein attributes for NPTX2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47042 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    • Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).

neXtProt entry for NPTX2 Gene

Proteomics data for NPTX2 Gene at MOPED

Post-translational modifications for NPTX2 Gene

  • Glycosylation at Asn 148, Asn 189, and Asn 393
  • Modification sites at PhosphoSitePlus

Other Protein References for NPTX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPTX2 Gene

Domains & Families for NPTX2 Gene

Gene Families for NPTX2 Gene

Protein Domains for NPTX2 Gene

Suggested Antigen Peptide Sequences for NPTX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47972

UniProtKB/Swiss-Prot:

NPTX2_HUMAN :
  • Contains 1 pentaxin domain.
Domain:
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with NPTX2: view

Function for NPTX2 Gene

Molecular function for NPTX2 Gene

GENATLAS Biochemistry:
pentaxin (pentraxin) 2,expressed in brain and other tissues,mediating the uptake of synaptic material and presynaptic toxins
UniProtKB/Swiss-Prot Function:
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).

Gene Ontology (GO) - Molecular Function for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NPTX2: view
genes like me logo Genes that share phenotypes with NPTX2: view

Animal Models for NPTX2 Gene

MGI Knock Outs for NPTX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPTX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPTX2 Gene

Localization for NPTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPTX2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPTX2 Gene COMPARTMENTS Subcellular localization image for NPTX2 gene
Compartment Confidence
extracellular 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NPTX2: view

Pathways & Interactions for NPTX2 Gene

SuperPathways for NPTX2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NPTX2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265634%0d%0a9606.ENSP00000327545%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: P47972-NPTX2_HUMAN ENSP00000265634 for NPTX2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission NAS 8530029
GO:0008306 associative learning IEA --
genes like me logo Genes that share ontologies with NPTX2: view

No data available for Pathways by source and SIGNOR curated interactions for NPTX2 Gene

Drugs & Compounds for NPTX2 Gene

(1) Drugs for NPTX2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(1) Additional Compounds for NPTX2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
genes like me logo Genes that share compounds with NPTX2: view

Transcripts for NPTX2 Gene

mRNA/cDNA for NPTX2 Gene

Unigene Clusters for NPTX2 Gene

Neuronal pentraxin II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPTX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPTX2 Gene

No ASD Table

Relevant External Links for NPTX2 Gene

GeneLoc Exon Structure for
NPTX2
ECgene alternative splicing isoforms for
NPTX2

Expression for NPTX2 Gene

mRNA expression in normal human tissues for NPTX2 Gene

mRNA differential expression in normal tissues according to GTEx for NPTX2 Gene

This gene is overexpressed in Pituitary (x10.7).

Protein differential expression in normal tissues from HIPED for NPTX2 Gene

This gene is overexpressed in Vitreous humor (30.0), Islet of Langerhans (20.9), and Frontal cortex (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPTX2 Gene



SOURCE GeneReport for Unigene cluster for NPTX2 Gene Hs.3281

mRNA Expression by UniProt/SwissProt for NPTX2 Gene

P47972-NPTX2_HUMAN
Tissue specificity: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis
genes like me logo Genes that share expression patterns with NPTX2: view

Protein tissue co-expression partners for NPTX2 Gene

Primer Products

In Situ Assay Products

Orthologs for NPTX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPTX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPTX2 35
  • 90.98 (n)
  • 96.14 (a)
NPTX2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPTX2 35
  • 90.18 (n)
  • 96.62 (a)
NPTX2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nptx2 35
  • 88.81 (n)
  • 97.32 (a)
Nptx2 16
Nptx2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPTX2 35
  • 99.38 (n)
  • 100 (a)
NPTX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nptx2 35
  • 88.33 (n)
  • 96.14 (a)
oppossum
(Monodelphis domestica)
Mammalia NPTX2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPTX2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPTX2 35
  • 75.97 (n)
  • 85.44 (a)
NPTX2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPTX2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nptx2 35
  • 69.98 (n)
  • 75.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18755 35
nptx2a 35
  • 70.03 (n)
  • 67.98 (a)
nptx2a 36
  • 66 (a)
OneToMany
nptx2b 36
  • 63 (a)
OneToMany
Species with no ortholog for NPTX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPTX2 Gene

ENSEMBL:
Gene Tree for NPTX2 (if available)
TreeFam:
Gene Tree for NPTX2 (if available)

Paralogs for NPTX2 Gene

Paralogs for NPTX2 Gene

(2) SIMAP similar genes for NPTX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPTX2: view

Variants for NPTX2 Gene

Sequence variations from dbSNP and Humsavar for NPTX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs386689 -- 98,615,431(+) ACCTA(G/T)GTCTA upstream-variant-2KB
rs397246 -- 98,627,351(+) TGGGT(A/G)CAGGG intron-variant
rs404895 -- 98,627,379(+) AGGGT(A/G)GGTGC intron-variant
rs425318 -- 98,627,378(+) CAGGG(C/T)GGGTG intron-variant
rs443502 -- 98,627,371(+) GTGGG(C/T)ACAGG intron-variant

Variation tolerance for NPTX2 Gene

Residual Variation Intolerance Score: 26.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPTX2 Gene

HapMap Linkage Disequilibrium report
NPTX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPTX2 Gene

Disorders for NPTX2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NPTX2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • paroxysmal sleep
melas syndrome
  • mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association
Search NPTX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPTX2

Genetic Association Database (GAD)
NPTX2
Human Genome Epidemiology (HuGE) Navigator
NPTX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPTX2
genes like me logo Genes that share disorders with NPTX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPTX2 Gene

Publications for NPTX2 Gene

  1. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. (PMID: 8530029) Hsu Y.-C. … Perin M.S. (Genomics 1995) 2 23 67
  2. Excitation-transcription coupling via calcium/calmodulin-dependent protein kinase/ERK1/2 signaling mediates the coordinate induction of VGLUT2 and Narp triggered by a prolonged increase in glutamatergic synaptic activity. (PMID: 20212045) Doyle S. … Erickson J.D. (J. Biol. Chem. 2010) 23 67
  3. Long-term treatment with antidepressants, but not environmental stimulation, induces expression of NP2 mRNA in hippocampus and medial habenula. (PMID: 20223226) Bjartmar L. … Hallbeck M. (Brain Res. 2010) 23 67
  4. Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats. (PMID: 20105316) Christensen K.V. … Egebjerg J. (BMC Neurosci 2010) 23 67
  5. Nicotine and Delta(9)-tetrahydrocannabinol withdrawal induce Narp in the central nucleus of the amygdala. (PMID: 19084905) Reti I.M. … Baraban J.M. (Synapse 2009) 23 67

Products for NPTX2 Gene

Sources for NPTX2 Gene

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