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Aliases for NPTX2 Gene

Aliases for NPTX2 Gene

  • Neuronal Pentraxin II 2 3 4
  • Apexin 2 3
  • NP-II 3 4
  • NP2 3 4
  • Neuronal Activity-Regulated Pentaxin 3
  • Neuronal Pentraxin-2 3
  • NARP 3

External Ids for NPTX2 Gene

Previous GeneCards Identifiers for NPTX2 Gene

  • GC07P096781
  • GC07P097844
  • GC07P097858
  • GC07P097891
  • GC07P098084
  • GC07P098246
  • GC07P092845

Summaries for NPTX2 Gene

Entrez Gene Summary for NPTX2 Gene

  • This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

GeneCards Summary for NPTX2 Gene

NPTX2 (Neuronal Pentraxin II) is a Protein Coding gene. Diseases associated with NPTX2 include visual pathway disease and pearson syndrome. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for NPTX2 Gene

  • Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).

Gene Wiki entry for NPTX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPTX2 Gene

Genomics for NPTX2 Gene

Regulatory Elements for NPTX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPTX2 Gene

Start:
98,617,285 bp from pter
End:
98,629,869 bp from pter
Size:
12,585 bases
Orientation:
Plus strand

Genomic View for NPTX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPTX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPTX2 Gene

Proteins for NPTX2 Gene

  • Protein details for NPTX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47972-NPTX2_HUMAN
    Recommended name:
    Neuronal pentraxin-2
    Protein Accession:
    P47972
    Secondary Accessions:
    • A4D267
    • Q86XV7
    • Q96G70

    Protein attributes for NPTX2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47042 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    • Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).

neXtProt entry for NPTX2 Gene

Proteomics data for NPTX2 Gene at MOPED

Post-translational modifications for NPTX2 Gene

  • Glycosylation at Asn148, Asn189, and Asn393
  • Modification sites at PhosphoSitePlus

Other Protein References for NPTX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPTX2 Gene

Domains for NPTX2 Gene

Protein Domains for NPTX2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NPTX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47972

UniProtKB/Swiss-Prot:

NPTX2_HUMAN :
  • P47972
Domain:
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with NPTX2: view

No data available for Gene Families for NPTX2 Gene

Function for NPTX2 Gene

Molecular function for NPTX2 Gene

GENATLAS Biochemistry: pentaxin (pentraxin) 2,expressed in brain and other tissues,mediating the uptake of synaptic material and presynaptic toxins
UniProtKB/Swiss-Prot Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).

Gene Ontology (GO) - Molecular Function for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NPTX2: view
genes like me logo Genes that share phenotypes with NPTX2: view

Animal Models for NPTX2 Gene

MGI Knock Outs for NPTX2:

Animal Model Products

CRISPR Products

miRNA for NPTX2 Gene

miRTarBase miRNAs that target NPTX2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPTX2 Gene

Localization for NPTX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPTX2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPTX2 Gene COMPARTMENTS Subcellular localization image for NPTX2 gene
Compartment Confidence
extracellular 3
mitochondrion 3
endoplasmic reticulum 2
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NPTX2: view

Pathways for NPTX2 Gene

SuperPathways for NPTX2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NPTX2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265634%0d%0a9606.ENSP00000327545%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000265634 P47972-NPTX2_HUMAN for NPTX2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NPTX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission NAS 8530029
genes like me logo Genes that share ontologies with NPTX2: view

No data available for Pathways by source for NPTX2 Gene

Compounds for NPTX2 Gene

(1) HMDB Compounds for NPTX2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for NPTX2 Gene

Compound -log(P) Hits PubMed IDs
glutamate 20.5 3
genes like me logo Genes that share compounds with NPTX2: view

Transcripts for NPTX2 Gene

mRNA/cDNA for NPTX2 Gene

Unigene Clusters for NPTX2 Gene

Neuronal pentraxin II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPTX2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPTX2 Gene

No ASD Table

Relevant External Links for NPTX2 Gene

GeneLoc Exon Structure for
NPTX2
ECgene alternative splicing isoforms for
NPTX2

Expression for NPTX2 Gene

mRNA expression in normal human tissues for NPTX2 Gene

mRNA differential expression in normal tissues according to GTEx for NPTX2 Gene

This gene is overexpressed in Pituitary (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPTX2 Gene

SOURCE GeneReport for Unigene cluster for NPTX2 Gene Hs.3281

mRNA Expression by UniProt/SwissProt for NPTX2 Gene

P47972-NPTX2_HUMAN
Tissue specificity: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis
genes like me logo Genes that share expressions with NPTX2: view

In Situ Assay Products

Orthologs for NPTX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPTX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPTX2 35
  • 99.38 (n)
  • 100 (a)
NPTX2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPTX2 35
  • 90.98 (n)
  • 96.14 (a)
NPTX2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPTX2 35
  • 90.18 (n)
  • 96.62 (a)
NPTX2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nptx2 35
  • 88.81 (n)
  • 97.32 (a)
Nptx2 16
Nptx2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPTX2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPTX2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nptx2 35
  • 88.33 (n)
  • 96.14 (a)
chicken
(Gallus gallus)
Aves NPTX2 35
  • 75.97 (n)
  • 85.44 (a)
NPTX2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPTX2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nptx2 35
  • 69.98 (n)
  • 75.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18755 35
nptx2a 35
  • 70.03 (n)
  • 67.98 (a)
nptx2a 36
  • 66 (a)
OneToMany
nptx2b 36
  • 63 (a)
OneToMany
Species with no ortholog for NPTX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPTX2 Gene

ENSEMBL:
Gene Tree for NPTX2 (if available)
TreeFam:
Gene Tree for NPTX2 (if available)

Paralogs for NPTX2 Gene

Paralogs for NPTX2 Gene

Selected SIMAP similar genes for NPTX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPTX2: view

Variants for NPTX2 Gene

Sequence variations from dbSNP and Humsavar for NPTX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs386689 -- 98,615,431(+) ACCTA(G/T)GTCTA upstream-variant-2KB
rs397246 -- 98,627,351(+) TGGGT(A/G)CAGGG intron-variant
rs404895 -- 98,627,379(+) AGGGT(A/G)GGTGC intron-variant
rs425318 -- 98,627,378(+) CAGGG(C/T)GGGTG intron-variant
rs443502 -- 98,627,371(+) GTGGG(C/T)ACAGG intron-variant

Relevant External Links for NPTX2 Gene

HapMap Linkage Disequilibrium report
NPTX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPTX2 Gene

Disorders for NPTX2 Gene

(1) Novoseek inferred disease relationships for NPTX2 Gene

Disease -log(P) Hits PubMed IDs
narcolepsy 60.1 3

Relevant External Links for NPTX2

Genetic Association Database (GAD)
NPTX2
Human Genome Epidemiology (HuGE) Navigator
NPTX2
genes like me logo Genes that share disorders with NPTX2: view

No data available for UniProtKB/Swiss-Prot for NPTX2 Gene

Publications for NPTX2 Gene

  1. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. (PMID: 8530029) Hsu Y.-C. … Perin M.S. (Genomics 1995) 2 3 4 23
  2. No association between the neuronal pentraxin II gene polymorphism and autism. (PMID: 17408830) Marui T. … Sasaki T. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2007) 3 23 48
  3. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PMID: 16115696) Poulsen T.T. … Poulsen H.S. (Lung Cancer 2005) 3 23
  4. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PMID: 9261167) Dodds D.C. … Perin M.S. (J. Biol. Chem. 1997) 3 23
  5. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. (PMID: 17987278) Moran L.B. … Graeber M.B. (Acta Neuropathol. 2008) 3 23

Products for NPTX2 Gene

Sources for NPTX2 Gene

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