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NPTX2 Gene

protein-coding   GIFtS: 57
GCID: GC07P098246

Neuronal Pentraxin II

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal Pentraxin II1 2 3     NARP2
apexin1 2     Neuronal Activity-Regulated Pentaxin2
NP-II2 3     Neuronal Pentraxin-22
NP22 3     

External Ids:    HGNC: 79531   Entrez Gene: 48852   Ensembl: ENSG000001062367   OMIM: 6007505   UniProtKB: P479723   

Export aliases for NPTX2 gene to outside databases

Previous GC identifers: GC07P096781 GC07P097844 GC07P097858 GC07P097891 GC07P098084 GC07P092845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPTX2 Gene:
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive
protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses,
resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson
disease (PD) tissues suggests that the protein may be involved in the pathology of PD. (provided by RefSeq, Feb
2009)

GeneCards Summary for NPTX2 Gene:
NPTX2 (neuronal pentraxin II) is a protein-coding gene. Diseases associated with NPTX2 include neurohypophyseal diabetes insipidus, and pearson syndrome. An important paralog of this gene is APCS.

UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds
to agar matrix in a calcium-dependent manner (By similarity)

Gene Wiki entry for NPTX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPTX2 gene promoter:
         NRSF form 1   MyoD   POU3F2 (N-Oct-5b)   Nkx2-5   NRSF form 2   C/EBPalpha   IRF-2   S8   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPTX2 promoter sequence
   Search Chromatin IP Primers for NPTX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPTX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

NPTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098246:  view genomic region     (about GC identifiers)

Start:
98,246,597 bp from pter      End:
98,259,181 bp from pter
Size:
12,585 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 97,570,995-97,583,579     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972 (See protein sequence)
Recommended Name: Neuronal pentraxin-2 precursor  
Size: 431 amino acids; 47042 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR)
Secondary accessions: A4D267 Q86XV7 Q96G70

Explore the universe of human proteins at neXtProt for NPTX2: NX_P47972

Explore proteomics data for NPTX2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn148, Asn189, Asn393

  • See NPTX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002514.1  
    ENSEMBL proteins: 
     ENSP00000265634  

    NPTX2 Human Recombinant Protein Products:

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    Novus Biologicals NPTX2 Lysates
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    Cloud-Clone Corp. Proteins for NPTX2

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    Cloud-Clone Corp. CLIAs for NPTX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P47972

    ProtoNet protein and cluster: P47972

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Similarity: Contains 1 pentaxin domain


    NPTX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPTX2_HUMAN, P47972
    Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds
    to agar matrix in a calcium-dependent manner (By similarity)

         Genatlas biochemistry entry for NPTX2:
    pentaxin (pentraxin) 2,expressed in brain and other tissues,mediating the uptake of synaptic material and
    presynaptic toxins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0046872metal ion binding IEA--
         
    NPTX2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nptx2):
     behavior/neurological  nervous system  vision/eye 

    NPTX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NPTX2: Nptx2tm1Awj Nptx2tm1Mspn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPTX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPTX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPTX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPTX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NPTX2:
    hsa-mir-423-3p (MIRT042492)

    Block miRNA regulation of human, mouse, rat NPTX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNPTX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NPTX2
    Predesigned siRNA for gene silencing in human, mouse, rat NPTX2

    Gene Editing
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    OriGene clones in human, mouse for NPTX2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: NPTX2 (NM_002523)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTX2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NPTX2
    ESI BIO PureStem Progenitor for NPTX2: 
    PureStem MEL2, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPTX2_HUMAN, P47972: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    mitochondrion3
    endoplasmic reticulum2
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    NPTX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NPTX2: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPTX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NPTX2 (P479723 ENSP000002656344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NPTXRO955023, ENSP000003275454I2D: score=1 STRING: ENSP00000327545
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission NAS8530029

    NPTX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPTX2

    1 HMDB Compound for NPTX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for NPTX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 20.5 3 20212045 (2), 12196584 (1)



    NPTX2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPTX2 gene: 
    NM_002523.2  

    Unigene Cluster for NPTX2:

    Neuronal pentraxin II
    Hs.3281  [show with all ESTs]
    Unigene Representative Sequence: BC048275
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265634(uc003upl.2) ENST00000466102

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NPTX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidNPTX2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NPTX2
    Predesigned siRNA for gene silencing in human, mouse, rat NPTX2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPTX2 (NM_002523)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTX2
    Primer
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    OriGene qPCR primer pairs and template standards for NPTX2
    OriGene qSTAR qPCR primer pairs in human, mouse for NPTX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPTX2
      QuantiTect SYBR Green Assays in human, mouse, rat NPTX2
      QuantiFast Probe-based Assays in human, mouse, rat NPTX2

    Additional mRNA sequence: 

    AK311250.1 BC009924.2 BC034781.1 BC035339.1 BC048275.1 U26662.1 

    3 DOTS entries:

    DT.113314  DT.92388407  DT.113315 

    Selected AceView cDNA sequences (see all 94):

    BQ286410 Z39297 F12910 BM697956 BI438484 BC048275 CD513689 BX117099 
    AA628155 CA848611 BM926764 CD512988 BC009924 T32853 BM893865 BG654715 
    BC034781 AA970298 AI570405 NM_002523 BE552181 H20073 BX442379 BI561105 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPTX2 expression in normal human tissues (normalized intensities)      NPTX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCATCCTGA
    NPTX2 Expression
    About this image


    NPTX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             Ventral/hypothalamic-like neurons
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Periosteum
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    NPTX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPTX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3281

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Tissue specificity: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis

        Pathway & Disease-focused RT2 Profiler PCR Array including NPTX2: 
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPTX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nptx21 , 5 neuronal pentraxin 21, 5 88.81(n)1
    97.32(a)1
      5 (84.58 cM)5
    533241  NM_016789.31  NP_058069.11 
     1445458875 
    chicken
    (Gallus gallus)
    Aves NPTX21 neuronal pentraxin II 75.97(n)
    85.44(a)
      416438  XM_414750.4  XP_414750.3 
    lizard
    (Anolis carolinensis)
    Reptilia NPTX26
    neuronal pentraxin II
    78(a)
    1 ↔ 1
    GL343385.1(994531-1005868)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nptx21 neuronal pentraxin 2 69.98(n)
    75.68(a)
      100124882  NM_001102834.1  NP_001096304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187552 Transcribed sequence with weak similarity to protein more 70.97(n)    CF996857.1 


    ENSEMBL Gene Tree for NPTX2 (if available)
    TreeFam Gene Tree for NPTX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPTX2 gene
    APCS2  CRP2  PTX42  NPTX12  NPTXR2  PTX32  
    2 SIMAP similar genes for NPTX2 using alignment to 1 protein entry:     NPTX2_HUMAN:
    NPTX1    NPTXR

    NPTX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPTX2 (see all 298)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457924641,2
    C--97572279(+) TCTCT-/CCCCCC 1 -- int10--------
    rs1847535551,2
    --97572287(+) CCCCCC/TCCCCC 1 -- int10--------
    rs30639211,2
    C--98256084(+) ACAGA-/ACA   
      G
    /CAGA
    TCCCT
    1 -- int10--------
    rs1922750461,2
    C--101548116(+) GTTTAA/CTTATT 1 -- us2k10--------
    rs1840074421,2
    --101548146(+) TCAAGC/TAGTTG 1 -- us2k10--------
    rs3866891,2
    H--101548249(+) ACCTAG/TGTCTA 1 -- us2k15Minor allele frequency- T:0.00MN NS EA 598
    rs1378907921,2
    --101548283(+) TATGAA/GTGAAA 1 -- us2k10--------
    rs1494946731,2
    --101548317(+) GAATAA/GTTTTG 1 -- us2k10--------
    rs1181111411,2
    C,F--101548328(+) AAAACG/TTCTGG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs750511651,2
    C,F--101548406(+) ATTATT/GGTAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for NPTX2 (98246597 - 98259181 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPTX2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPTX2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPTX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600750    OMIM disorders: --

    Selected diseases for NPTX2 (see all 24):    About MalaCards
    neurohypophyseal diabetes insipidus    pearson syndrome    kearns-sayre syndrome    neuronitis
    diabetes insipidus    narcolepsy    mitochondrial encephalomyopathy    parkinson's disease
    encephalomyopathy    lactic acidosis    autism spectrum disorder    mood disorder
    retinitis pigmentosa    malignant glioma    endometriosis    infertility
    pancreatic cancer    mental retardation    neuropathy    pancreatitis

    9 diseases from the University of Copenhagen DISEASES database for NPTX2:
    Retinitis pigmentosa     Leigh disease     Kearns-Sayre syndrome     Neurohypophyseal diabetes insipidus
    Mitochondrial encephalomyopathy     Neuropathy     Pearson syndrome     Visual pathway disease
    Lactic acidosis

    NPTX2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NPTX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 60.1 3 16135770 (2), 16247044 (1)

    Genetic Association Database (GAD): NPTX2
    Human Genome Epidemiology (HuGE) Navigator: NPTX2 (3 documents)

    Export disorders for NPTX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPTX2 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with NPTX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. (PubMed id 8530029)1, 2, 3, 9 Hsu Y.-C. and Perin M.S. (Genomics 1995)
    2. No association between the neuronal pentraxin II gene polymorphism and autism. (PubMed id 17408830)1, 4, 9 Marui T....Sasaki T. (amp 2007)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1, 2 Kirkpatrick L.L.... Perin M.S. (J. Biol. Chem. 2000)
    8. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. (PubMed id 17987278)1, 9 Moran L.B....Graeber M.B. (Acta Neuropathol. 2008)
    9. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (J. Biol. Chem. 1997)
    10. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (Lung Cancer 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4885 HGNC: 7953 AceView: NPTX2 Ensembl:ENSG00000106236 euGenes: HUgn4885
    ECgene: NPTX2 H-InvDB: NPTX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPTX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPTX2 gene:
    Search GeneIP for patents involving NPTX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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