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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPTX2 Gene

protein-coding   GIFtS: 56
GCID: GC07P098246

neuronal pentraxin II
 Explore 19 diseases affiliated with
NPTX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPTX2    

Aliases
for NPTX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuronal Pentraxin II1 2 3     Apexin1
NP-II2 3     Neuronal Activity-Regulated Pentaxin2
NP22 3     Neuronal Pentraxin-22
NARP2     

External Ids:    HGNC: 79531   Entrez Gene: 48852   Ensembl: ENSG000001062367   OMIM: 6007505   UniProtKB: P479723   

Export aliases for NPTX2 gene to outside databases

Previous GC identifers: GC07P096781 GC07P097844 GC07P097858 GC07P097891 GC07P098084 GC07P092845


Summaries
for NPTX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NPTX2:
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive
protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses,
resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease
(PD) tissues suggests that the protein may be involved in the pathology of PD. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to
agar matrix in a calcium-dependent manner (By similarity)

Gene Wiki entry for NPTX2


Genomic Views
for NPTX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPTX2 gene promoter:
         NRSF form 1   MyoD   POU3F2 (N-Oct-5b)   Nkx2-5   NRSF form 2   C/EBPalpha   IRF-2   S8   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPTX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPTX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.3-q22.1

NPTX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTX2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098246:  view genomic region     (about GC identifiers)

Start:
 98,246,597 bp from pter      End:
 98,259,181 bp from pter
Size:
 12,585 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 97,570,995-97,583,579     

Proteins
for NPTX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972 (See protein sequence)
Recommended Name: Neuronal pentraxin-2 precursor  
Size: 431 amino acids; 47042 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR)
Subcellular location: Secreted (By similarity)
Secondary accessions: A4D267 Q86XV7 Q96G70

Explore the universe of human proteins at neXtProt for NPTX2: NX_P47972

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47972

    • NPTX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002514.1  
    ENSEMBL proteins: 
     ENSP00000265634  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for NPTX2 (Neuronal Pentraxin 2)
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    Novus Biologicals NPTX2 Proteins
    Novus Biologicals NPTX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPTX2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--


    NPTX2 for ontologies           About GeneDecksing



    NPTX2 Antibody Products: 
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    Uscn Antibodies for NPTX2
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    Uscn ELISAs and CLIAs for NPTX2

    Protein Domains /
    Families
    for NPTX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPTX2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P47972

    ProtoNet protein and cluster: P47972

    1 Blocks protein family: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Similarity: Contains 1 pentaxin domain


    Function
    for NPTX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to
    agar matrix in a calcium-dependent manner (By similarity)

         Genatlas biochemistry entry for NPTX2:
    pentaxin (pentraxin) 2,expressed in brain and other tissues,mediating the uptake of synaptic material and presynaptic
    toxins

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTX2
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: NPTX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPTX2 (see all 7)
    OriGene shRNA RFP: NPTX2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTX2

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTX2 (see all 3)
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    Cell Line
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    LifeMap BioReagents: cell line associated with NPTX2: PureStem MEL2, NCr-fac Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0030246carbohydrate binding ----
    GO:0046872metal ion binding IEA--


    NPTX2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NPTX2: Nptx2tm1Awj Nptx2tm1Mspn
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nptx2):
     behavior/neurological  nervous system  vision/eye 

    NPTX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPTX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPTX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NPTX2 (P479723 ENSP000002656344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NPTXRO955023, ENSP000003275454I2D: score=1 STRING: ENSP00000327545
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission NAS8530029


    NPTX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPTX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPTX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPTX2

    1 HMDB Compound for NPTX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for NPTX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 20.5 3 20212045 (2), 12196584 (1)

    Search CenterWatch for drugs/clinical trials and news about NPTX2 

    Transcripts
    for NPTX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPTX2 gene: 
    NM_002523.2  

    Unigene Cluster for NPTX2:

    Neuronal pentraxin II
    Hs.3281  [show with all ESTs]
    Unigene Representative Sequence: BC048275
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265634(uc003upl.2) ENST00000466102

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX2 (see all 27):
    hsa-miR-194* hsa-miR-4286 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-374a hsa-miR-410 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: NPTX2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPTX2 (see all 7)
    OriGene shRNA RFP: NPTX2
    OriGene siRNA: NPTX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTX2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTX2

    Additional cDNA sequence: 

    AK311250.1 BC009924.2 BC034781.1 BC035339.1 BC048275.1 U26662.1 

    3 DOTS entries:

    DT.113314  DT.92388407  DT.113315 

    24/94 AceView cDNA sequences (see all 94):

    AA628155 AI570405 BX117099 F12910 BC009924 NM_002523 BC034781 Z39297 
    BG654715 BQ286410 T32853 CD512988 BM697956 CA848611 AA970298 BC048275 
    BM893865 CD513689 BM926764 BI438484 BQ787377 BU071325 BI439576 BQ109438 

    GeneLoc Exon Structure


    Expression
    for NPTX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPTX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCATCCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPTX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Ventral/hypothalamic-like neurons (Generation of midbra...)
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NPTX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPTX2

    SOURCE GeneReport for Unigene cluster: Hs.3281

    UniProtKB/Swiss-Prot: NPTX2_HUMAN, P47972
    Tissue specificity: Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis

        SABiosciences Expression via Pathway-Focused PCR Array including NPTX2: 
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NPTX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPTX2 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NPTX21 neuronal pentraxin II 76.13(n)
    84.51(a)    		   416438  XM_414750.3  XP_414750.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NPTX26
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343385.1(997436-1005521)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.187552 Transcribed sequence with weak similarity to protein more 70.97(n)    CF996857.1 


    ENSEMBL Gene Tree for NPTX2 (if available)
    TreeFam Gene Tree for NPTX2 (if available) 

    Paralogs
    for NPTX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPTX2 gene
    APCS2  CBX62  CRP2  PTX42  NPTX12  PTX32  NPTXR2  
    2 SIMAP similar genes for NPTX2 using alignment to 1 protein entry:     NPTX2_HUMAN:
    NPTX1    NPTXR

    NPTX2 for paralogs           About GeneDecksing



    Genomic Variants
    for NPTX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/231 NCBI SNPs in NPTX2 are shown (see all 231)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs3866891,2
    		H--97569141(+) ACCTAG/TGTCTA 1 -- us2k15Minor allele frequency- T:0.00MN NS EA 598
    rs750511651,2
    		F,--97569298(+) ATTATT/GGTAAT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs737117161,2
    		C,--97569383(+) CAGTCA/GAGGTC 1 -- us2k13Minor allele frequency- G:0.04WA NA 240
    rs286991961,2
    		C,F,H,--97570117(+) ACCGGG/TCACTG 1 -- us2k16Minor allele frequency- T:0.02NS NA 678
    rs102630711,2
    		C,F,H,--97570994(+) CAGGCC/TAGAGT 1 -- us2k16Minor allele frequency- T:0.01NS NA 684
    rs758205771,2
    		--97571122(+) CGCCCC/AGACGG 1 -- ut512Minor allele frequency- A:0.09CSA EA 121
    rs731437021,2
    		C,--97571686(+) GGGGCC/TTGGCC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1129563921,2
    		--97572169(+) AGGGGC/TAACCT 1 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs1116005661,2
    		--97572470(+) TACTTC/ATCAGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs737117171,2
    		C,F,--97573197(+) ACCAAA/GAAAGC 1 -- int14Minor allele frequency- G:0.06WA CSA NA 242

    HapMap Linkage Disequilibrium report for NPTX2 (98246597 - 98259181 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPTX2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPTX2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPTX2

    Disorders / Diseases
    for NPTX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPTX2 for disorders           About GeneDecksing

    OMIM gene information: 600750    OMIM disorders: --

    19 diseases for NPTX2:    About MalaCards
    neuronitis    kearns-sayre syndrome    parkinson's disease    neurohypophyseal diabetes insipidus
    diabetes insipidus    mitochondrial encephalomyopathy    autism spectrum disorder    lactic acidosis
    pearson syndrome    leigh disease    malignant glioma    narcolepsy
    encephalomyopathy    seizures    endometriosis    infertility
    pancreatic cancer    lung cancer    pancreatitis

    9 diseases from the University of Copenhagen DISEASES database for NPTX2:
    Leigh disease     Retinitis pigmentosa     Kearns-Sayre syndrome     Neurohypophyseal diabetes insipidus
    Mitochondrial encephalomyopathy     Pearson syndrome     Neuropathy     Visual pathway disease
    Lactic acidosis

    1 Novoseek disease relationship for NPTX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    narcolepsy 60.1 3 16135770 (2), 16247044 (1)

    Human Genome Epidemiology (HuGE) Navigator: NPTX2 (3 documents)

    Export disorders for NPTX2 gene to outside databases

    Publications
    for NPTX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPTX2 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with NPTX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. (PubMed id 8530029)1, 2, 3, 9 Hsu Y.-C. and Perin M.S. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. (PubMed id 10748068)1, 2 Kirkpatrick L.L....Perin M.S. (2000)
    6. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. (PubMed id 17987278)1, 9 Moran L.B....Graeber M.B. (2008)
    7. No association between the neuronal pentraxin II gene polymorphism and autism. (PubMed id 17408830)1, 9 Marui T....Sasaki T. (2007)
    8. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PubMed id 9261167)1, 9 Dodds D.C....Perin M.S. (1997)
    9. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)
    10. The role of quantitative NPTX2 hypermethylation as a n ovel serum diagnostic marker in pancreatic cancer. (PubMed id 21778928)1 Park J.K....Yoon Y.B. (2012)

    External Searches for NPTX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NPTX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4885 HGNC: 7953 AceView: NPTX2 Ensembl:ENSG00000106236 euGenes: HUgn4885
    ECgene: NPTX2 H-InvDB: NPTX2

    Other Databases showing NPTX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPTX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPTX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPTX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPTX2 gene:
    Search GeneIP for patents involving NPTX2

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