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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPTX1 Gene

protein-coding   GIFtS: 55
GCID: GC17M078440

neuronal pentraxin I
 Explore 12 diseases affiliated with
NPTX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPTX1    

Aliases
for NPTX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neuronal Pentraxin I1 2 3
NP12 3 5
NP-I2 3
Neuronal Pentraxin-12

External Ids:    HGNC: 79521   Entrez Gene: 48842   Ensembl: ENSG000001712467   OMIM: 6023675   UniProtKB: Q158183   
ORGUL members:         
NONCODE:n340916    

Export aliases for NPTX1 gene to outside databases

Previous GC identifers: GC17M078086 GC17M081759 GC17M079003 GC17M079141 GC17M076055 GC17M073881


Summaries
for NPTX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NPTX1:
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which
encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous
system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NPTX1_HUMAN, Q15818
Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

Gene Wiki entry for NPTX1


Genomic Views
for NPTX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPTX1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   NRSF form 1   Lmo2   E2F-2   NRSF form 2   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NPTX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPTX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NPTX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPTX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M078440:  view genomic region     (about GC identifiers)

Start:
 78,440,633 bp from pter      End:
 78,451,643 bp from pter
Size:
 11,011 bases      Orientation:
 minus strand

Proteins
for NPTX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPTX1_HUMAN, Q15818 (See protein sequence)
Recommended Name: Neuronal pentraxin-1 precursor  
Size: 432 amino acids; 47122 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR) (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle (Potential)
Secondary accessions: B3KXH3 Q5FWE6

Explore the universe of human proteins at neXtProt for NPTX1: NX_Q15818

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15818

    • NPTX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002513.2  
    ENSEMBL proteins: 
     ENSP00000307549  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NPTX1 (Neuronal Pentraxin 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NPTX1
    OriGene Protein Over-expression Lysate: NPTX1
    OriGene Custom Protein Services for NPTX1 
    GenScript Custom Purified and Recombinant Proteins Services for NPTX1
    Novus Biologicals NPTX1 Protein
    Novus Biologicals NPTX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPTX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030133transport vesicle IEA--


    NPTX1 for ontologies           About GeneDecksing



    NPTX1 Antibody Products: 
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    Uscn Antibodies for NPTX1
    ThermoFisher Antibodies for NPTX1

    Assay Products for NPTX1: 
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    Uscn ELISAs and CLIAs for NPTX1

    Protein Domains /
    Families
    for NPTX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPTX1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q15818

    ProtoNet protein and cluster: Q15818

    1 Blocks protein family: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: NPTX1_HUMAN, Q15818
    Similarity: Contains 1 pentaxin domain


    Function
    for NPTX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPTX1_HUMAN, Q15818
    Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the
    synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity)

         Genatlas biochemistry entry for NPTX1:
    pentaxin (pentraxin) 1,neuronal,mediating the uptake of synaptic material and presynaptic toxins

    miRNA
    Products:            		miRTarBase miRNAs that target NPTX1:
    hsa-mir-210 (MIRT001930)

    OriGene 3'-UTR Clone: NPTX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTX1
    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX1 (see all 116):
    hsa-miR-3152-3p hsa-miR-520f hsa-miR-1224-3p hsa-miR-200a hsa-miR-128 hsa-miR-1260b hsa-miR-632 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPTX1 (see all 7)
    OriGene shRNA RFP: NPTX1
    OriGene siRNA: NPTX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPTX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTX1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NPTX1 (NM_002522)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NPTX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--


    NPTX1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nptx1tm1Mspn for NPTX1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nptx1):
     behavior/neurological  nervous system  vision/eye 

    NPTX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPTX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPTX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NPTX1 (Q158183 ENSP000003075494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPTXRO955023, ENSP000003275454I2D: score=1 STRING: ENSP00000327545
    PLXNA1Q9UIW23, ENSP000002517724I2D: score=1 STRING: ENSP00000251772
    RCN2Q142573, ENSP000003783494I2D: score=1 STRING: ENSP00000378349
    SUMO1ENSP000003760764STRING: ENSP00000376076
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8884281
    GO:0007268synaptic transmission TAS8884281
    GO:0007417central nervous system development TAS8884281
    GO:0060385axonogenesis involved in innervation IEA--


    NPTX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPTX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPTX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPTX1

    1 HMDB Compound for NPTX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    8 Novoseek chemical compound relationships for NPTX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mibolerone 74.3 8 12865321 (3), 15001595 (2)
    vegf 63.1 48 14666697 (4), 15126502 (4), 12385828 (4), 16376649 (3) (see all 14)
    iodide 53.8 3 15001595 (1), 11103823 (1), 12865321 (1)
    heparin 4.77 3 16899214 (2), 10842181 (1)
    tyrosine 0 4 10842181 (1), 15655556 (1), 11238106 (1)
    potassium 0 10 11031272 (4), 15630079 (4)
    lactate 0 1 8427710 (1)
    glutamate 0 3 15115814 (1), 16054439 (1), 17936538 (1)

    Search CenterWatch for drugs/clinical trials and news about NPTX1 

    Transcripts
    for NPTX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPTX1 gene: 
    NM_002522.3  

    Unigene Clusters for NPTX1:

    Neuronal pentraxin I
    Hs.514556  [show with all ESTs], Hs.715784  [show with all ESTs]
    Unigene Representative Sequences: BX537550, AK124701
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535681 ENST00000306773(uc002jyp.1) ENST00000571100 ENST00000575212


    miRNA
    Products:             		 OriGene 3'-UTR Clone: NPTX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPTX1
    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate NPTX1 (see all 116):
    hsa-miR-3152-3p hsa-miR-520f hsa-miR-1224-3p hsa-miR-200a hsa-miR-128 hsa-miR-1260b hsa-miR-632 hsa-miR-10b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPTX1 (see all 7)
    OriGene shRNA RFP: NPTX1
    OriGene siRNA: NPTX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPTX1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPTX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPTX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NPTX1 (NM_002522)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPTX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPTX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPTX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPTX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPTX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTX1

    Additional cDNA sequence: AK124701.1 

    7 DOTS entries:

    DT.87016482  DT.100009436  DT.101973001  DT.120995880  DT.120995879  DT.95138063  DT.100676946 

    24/93 AceView cDNA sequences (see all 93):

    T08921 BX110854 AI798972 AA322950 AL133850 AA325986 BE699746 AL119012 
    AU132539 BE700028 BU681270 BF667116 BX476337 AI075436 BE220979 AL138181 
    AK127335 CF128345 CD673942 BE700046 CK004047 AI088841 AK124701 AI919005 

    GeneLoc Exon Structure


    Expression
    for NPTX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPTX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTGTTGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPTX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See NPTX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPTX1

    SOURCE GeneReport for Unigene clusters: Hs.514556 Hs.715784
        SABiosciences Expression via Pathway-Focused PCR Arrays including NPTX1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Antifungal Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPTX1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPTX1

    Orthologs
    for NPTX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPTX1 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NPTX11 neuronal pentraxin I 83.14(n)
    83.61(a)    		   422078  XM_420081.3  XP_420081.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NPTX16
    		 --
    		 80(a)
    		 1 ↔ 1
    		 2(100252156-100258634)
    zebrafish
    (Danio rerio)    		 Actinopterygii nptx1l1 neuronal pentraxin 1 like 74.08(n)
    77.99(a)    		   405872  NM_212936.1  NP_998101.1 


    ENSEMBL Gene Tree for NPTX1 (if available)
    TreeFam Gene Tree for NPTX1 (if available) 

    Paralogs
    for NPTX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPTX1 gene
    NPTX22  APCS2  CBX62  CRP2  PTX42  PTX32  NPTXR2  
    3 SIMAP similar genes for NPTX1 using alignment to 1 protein entry:     NPTX1_HUMAN:
    NPTX2    NPTXR    CRP

    NPTX1 for paralogs           About GeneDecksing



    Genomic Variants
    for NPTX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/199 NCBI SNPs in NPTX1 are shown (see all 199)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1848024651,2
    		--78440200(+) AAAGCA/GGGAAG 1 -- ds50010--------
    rs1382626581,2
    		--78440230(+) GCCCCA/GCTAGC 1 -- ds50010--------
    rs75032191,2
    		C,F,H,--78440293(+) CACCTC/TGAACC 1 -- ds500116Minor allele frequency- T:0.25NS EA NA 2222
    rs1897788711,2
    		--78440319(+) ACCGCA/GAGTCC 1 -- ds50010--------
    rs1492019481,2
    		--78440348(+) AATGCA/GGAGTG 1 -- ds50010--------
    rs572703341,2
    		C,--78440558(+) TGGCTG/AGGGAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs604577961,2
    		C--78440700(+) AAAAA-/AGCAAG 1 -- ut312Minor allele frequency- A:0.00NA CSA 4
    rs1393495141,2
    		--78440802(+) CCAAAA/GGGCTG 1 -- ut310--------
    rs116529661,2
    		C,F,H,--78440867(+) ACATCG/AATTCT 1 -- ut3118Minor allele frequency- A:0.08NS EA NA WA 1964
    rs1428152821,2
    		--78440925(+) GGTTT-/GCTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NPTX1 (78440633 - 78451643 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NPTX1
         1 CNV: 73056

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPTX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NPTX1

    Disorders / Diseases
    for NPTX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPTX1 for disorders           About GeneDecksing

    OMIM gene information: 602367    OMIM disorders: --

    12 diseases for NPTX1:    About MalaCards
    neuronitis    human t-cell leukemia virus type 1    wallerian degeneration    t-cell leukemia
    prostate cancer    choroiditis    colon cancer    ovarian cancer
    leukemia    lung cancer    prostatitis    retinitis

    4 Novoseek disease relationships for NPTX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 20.9 2 14666697 (2)
    breast carcinoma 4.17 1 16513643 (1)
    metastasis 0 4 16773190 (2), 14666697 (1)
    tumors 0 24 16773190 (3), 11103823 (2), 18787945 (1), 12480257 (1) (see all 5)


    Export disorders for NPTX1 gene to outside databases

    Publications
    for NPTX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPTX1 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with NPTX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. (PubMed id 8884281)1, 2, 3, 9 Omeis I.A.... Perin M.S. (1996)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain. (PubMed id 17151277)1, 9 Abad M.A....Trullas R. (2006)
    5. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PubMed id 16115696)1, 9 Poulsen T.T....Poulsen H.S. (2005)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NPTX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing NPTX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4884 HGNC: 7952 AceView: NPTX1 Ensembl:ENSG00000171246 euGenes: HUgn4884
    ECgene: NPTX1 H-InvDB: NPTX1

    Other Databases showing NPTX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPTX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPTX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPTX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPTX1 gene:
    Search GeneIP for patents involving NPTX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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