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Aliases for NPTX1 Gene

Aliases for NPTX1 Gene

  • Neuronal Pentraxin 1 2 3
  • Neuronal Pentraxin I 2 3 4 5
  • NP-I 3 4
  • NP1 3 4

External Ids for NPTX1 Gene

Previous GeneCards Identifiers for NPTX1 Gene

  • GC17M078086
  • GC17M081759
  • GC17M079003
  • GC17M079141
  • GC17M076055
  • GC17M078440
  • GC17M073881

Summaries for NPTX1 Gene

Entrez Gene Summary for NPTX1 Gene

  • NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPTX1 Gene

NPTX1 (Neuronal Pentraxin 1) is a Protein Coding gene. Diseases associated with NPTX1 include wallerian degeneration. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for NPTX1 Gene

  • May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

Gene Wiki entry for NPTX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPTX1 Gene

Genomics for NPTX1 Gene

Regulatory Elements for NPTX1 Gene

Enhancers for NPTX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPTX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPTX1 Gene

80,466,833 bp from pter
80,477,843 bp from pter
11,011 bases
Minus strand

Genomic View for NPTX1 Gene

Genes around NPTX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPTX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPTX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPTX1 Gene

Proteins for NPTX1 Gene

  • Protein details for NPTX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal pentraxin-1
    Protein Accession:
    Secondary Accessions:
    • B3KXH3
    • Q5FWE6

    Protein attributes for NPTX1 Gene

    432 amino acids
    Molecular mass:
    47122 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).

neXtProt entry for NPTX1 Gene

Proteomics data for NPTX1 Gene at MOPED

Post-translational modifications for NPTX1 Gene

  • Glycosylation at Asn 154 and Asn 193
  • Modification sites at PhosphoSitePlus

Other Protein References for NPTX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPTX1 Gene

Domains & Families for NPTX1 Gene

Gene Families for NPTX1 Gene

Protein Domains for NPTX1 Gene

Suggested Antigen Peptide Sequences for NPTX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 pentaxin domain.
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with NPTX1: view

Function for NPTX1 Gene

Molecular function for NPTX1 Gene

GENATLAS Biochemistry:
pentaxin (pentraxin) 1,neuronal,mediating the uptake of synaptic material and presynaptic toxins
UniProtKB/Swiss-Prot Function:
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
genes like me logo Genes that share phenotypes with NPTX1: view

Animal Models for NPTX1 Gene

MGI Knock Outs for NPTX1:

Animal Model Products

CRISPR Products

miRNA for NPTX1 Gene

miRTarBase miRNAs that target NPTX1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPTX1 Gene

Localization for NPTX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPTX1 Gene

Cytoplasmic vesicle, secretory vesicle.

Subcellular locations from

Jensen Localization Image for NPTX1 Gene COMPARTMENTS Subcellular localization image for NPTX1 gene
Compartment Confidence
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NPTX1 Gene

Pathways & Interactions for NPTX1 Gene

SuperPathways for NPTX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPTX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8884281
GO:0007268 synaptic transmission TAS 8884281
GO:0007417 central nervous system development TAS 8884281
genes like me logo Genes that share ontologies with NPTX1: view

No data available for Pathways by source and SIGNOR curated interactions for NPTX1 Gene

Drugs & Compounds for NPTX1 Gene

(5) Drugs for NPTX1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for NPTX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NPTX1: view

Transcripts for NPTX1 Gene

Unigene Clusters for NPTX1 Gene

Neuronal pentraxin I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPTX1 Gene

No ASD Table

Relevant External Links for NPTX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPTX1 Gene

mRNA expression in normal human tissues for NPTX1 Gene

mRNA differential expression in normal tissues according to GTEx for NPTX1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.4), Brain - Cerebellum (x10.5), Brain - Frontal Cortex (BA9) (x5.3), Brain - Cortex (x5.2), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for NPTX1 Gene

This gene is overexpressed in Brain (31.4), Cerebrospinal fluid (29.0), and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPTX1 Gene

SOURCE GeneReport for Unigene cluster for NPTX1 Gene Hs.514556

genes like me logo Genes that share expression patterns with NPTX1: view

Protein tissue co-expression partners for NPTX1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NPTX1 Gene

Orthologs for NPTX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPTX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPTX1 35
  • 93.6 (n)
  • 96.99 (a)
NPTX1 36
  • 97 (a)
(Canis familiaris)
Mammalia NPTX1 35
  • 93.21 (n)
  • 95.83 (a)
NPTX1 36
  • 96 (a)
(Mus musculus)
Mammalia Nptx1 35
  • 91.67 (n)
  • 96.3 (a)
Nptx1 16
Nptx1 36
  • 96 (a)
(Pan troglodytes)
Mammalia NPTX1 35
  • 99.46 (n)
  • 99.77 (a)
NPTX1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nptx1 35
  • 90.97 (n)
  • 95.83 (a)
(Monodelphis domestica)
Mammalia NPTX1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia NPTX1 36
  • 62 (a)
(Gallus gallus)
Aves NPTX1 35
  • 83.17 (n)
  • 83.9 (a)
NPTX1 36
  • 78 (a)
(Anolis carolinensis)
Reptilia NPTX1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nptx1 35
  • 71.63 (n)
  • 78.54 (a)
(Danio rerio)
Actinopterygii nptx1l 35
  • 74.61 (n)
  • 77.89 (a)
nptx1l 36
  • 75 (a)
Species with no ortholog for NPTX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPTX1 Gene

Gene Tree for NPTX1 (if available)
Gene Tree for NPTX1 (if available)

Paralogs for NPTX1 Gene

Paralogs for NPTX1 Gene

(3) SIMAP similar genes for NPTX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPTX1: view

Variants for NPTX1 Gene

Sequence variations from dbSNP and Humsavar for NPTX1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10931 -- 80,467,247(-) ACTTC(C/T)GTACA utr-variant-3-prime
rs1804660 -- 80,467,243(-) CTGTA(A/C)ACAGT utr-variant-3-prime
rs1131608 -- 80,475,588(-) CCCCA(A/G)GAACG reference, missense
rs1131609 -- 80,471,902(-) CCAAG(C/G/T)TGCCT reference, synonymous-codon
rs1131610 -- 80,468,855(-) CTCGG(A/C/G)GTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPTX1 Gene

Variant ID Type Subtype PubMed ID
dgv3299n71 CNV Loss 21882294
esv24254 CNV Gain+Loss 19812545
dgv3300n71 CNV Loss 21882294
nsv524479 CNV Loss 19592680
dgv539n67 CNV Gain 20364138
nsv908992 CNV Loss 21882294
nsv828126 CNV Loss 20364138
nsv828127 CNV Gain 20364138

Variation tolerance for NPTX1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPTX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPTX1 Gene

Disorders for NPTX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPTX1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
- elite association - COSMIC cancer census association via MalaCards
Search NPTX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPTX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPTX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPTX1 Gene

Publications for NPTX1 Gene

  1. Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. (PMID: 8884281) Omeis I.A. … Perin M.S. (Genomics 1996) 2 3 4 23 67
  2. Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain. (PMID: 17151277) Abad M.A. … Trullas R. (J. Neurosci. 2006) 3 23
  3. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PMID: 16115696) Poulsen T.T. … Poulsen H.S. (Lung Cancer 2005) 3 23
  4. Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder. (PMID: 25053281) Rajkumar A.P. … rglum A.D. (Bipolar Disord 2015) 3
  5. Neuronal pentraxin 1 expression is regulated by hypoxia inducible factor-1I+. (PMID: 25498504) Botlagunta M. (Biochem. Biophys. Res. Commun. 2015) 3

Products for NPTX1 Gene

Sources for NPTX1 Gene