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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPSR1-AS1 Gene

RNA gene   GIFtS: 26
GCID: GC07M034387

NPSR1 Antisense RNA 1

(Previous name: NPSR1 antisense RNA 1 (non-protein coding))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
NPSR1 Antisense RNA 11 2
AAA12 5
Asthma-Associated Alternatively Spliced Gene 11
NPSR1 Antisense RNA 1 (Non-Protein Coding)1

External Ids:    HGNC: 221281   Entrez Gene: 4047442   Ensembl: ENSG000001970857   OMIM: 6085965   

Export aliases for NPSR1-AS1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPSR1-AS1 Gene:
This gene is located within a region that has been associated with asthma susceptibility. The locus is considered
non-protein-coding based on lack of protein homology and a lack of experimental support for an encoded protein.
Three alternatively spliced transcript variants have been identified for this gene. (provided by RefSeq, May
2010)

GeneCards Summary for NPSR1-AS1 Gene: 
NPSR1-AS1 (NPSR1 antisense RNA 1) is an RNA gene, and is affiliated with the processed_transcript RNA class. Diseases associated with NPSR1-AS1 include asthma.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPSR1-AS1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NPSR1-AS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPSR1-AS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPSR1-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

NPSR1-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPSR1-AS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M034387:  view genomic region     (about GC identifiers)

Start:
34,386,124 bp from pter      End:
34,911,194 bp from pter
Size:
525,071 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 34,430,522-34,918,952     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPSR1-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for NPSR1-AS1

Search CenterWatch for drugs/clinical trials and news about NPSR1-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NPSR1-AS1 gene (8 alternative transcripts): 
NM_207283.1  NM_207284.1  NM_207285.1  NM_207286.1  NM_207287.1  NM_207288.1  NM_207289.1  NM_207290.1  

Unigene Cluster for NPSR1-AS1:

NPSR1 antisense RNA 1
Hs.487951  [show with all ESTs]
Unigene Representative Sequence: NR_033664
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000419766(uc010kwo.2 uc010kwp.2 uc003tdz.3 uc010kwq.2)
ENST00000439852(uc003teb.1) ENST00000358772 ENST00000431669(uc011kaq.1)
ENST00000428922(uc010kwx.1) ENST00000436945(uc010kwy.3) ENST00000539747
ENST00000537560 ENST00000535640 ENST00000544556 ENST00000442669(uc003tek.4)

miRNA
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Additional mRNA sequence: 

AY312365.1 AY312366.1 AY312369.1 AY312370.1 AY312371.1 AY312372.1 AY312373.1 AY321515.1 
BC031961.1 BC130477.1 BX649082.1 NR_015356.2 NR_033664.1 NR_033665.1 U85653.1 

8 DOTS entries:

DT.102832533  DT.102832535  DT.203579  DT.445112  DT.75119637  DT.91958215  DT.102832529  DT.102832531 

24/30 AceView cDNA sequences (see all 30):

AY312367 U85653 NM_207285 NM_207286 NM_207289 AY312369 AY321516 AY312371 
AY312368 NM_207287 BX649082 BG723002 AY312365 AY321515 AY312370 AY312373 
NM_207283 NM_207290 AY312372 T95260 BC031961 BX489286 AY312364 NM_207288 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NPSR1-AS1    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:        -                           
SP3:                    -               


ECgene alternative splicing isoforms for NPSR1-AS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for NPSR1-AS1:none

NPSR1-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCATTAGCTC
NPSR1-AS1 Expression
About this image


Genevestigator expression for NPSR1-AS1

SOURCE GeneReport for Unigene cluster: Hs.487951
    SABiosciences Custom PCR Arrays for NPSR1-AS1
Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for NPSR1-AS1 (if available)
TreeFam Gene Tree for NPSR1-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/10174 SNPs in NPSR1-AS1 are shown (see all 10174)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1167338501,2
C,Funtested134824035(+) GCCATC/TGTCTA 1 -- int12Minor allele frequency- T:0.00WA NA 4768
rs2002294331,2
--34348573(+) ATGTA-/TGTC  
        
TACAC
2 -- int10--------
rs782971831,2
C,F--34357688(+) CACCAC/TGCCCG 2 -- int11Minor allele frequency- T:0.03WA 118
rs1914531961,2
--34357822(+) ATTTGA/GAGTAC 2 -- int10--------
rs736905451,2
C,F--34357832(+) CAGTTT/GCAGCT 2 -- int12Minor allele frequency- G:0.05WA 120
rs1814737981,2
--34357841(+) CTGAAC/TGTGTA 2 -- int10--------
rs1472860791,2
--34357844(+) AATGTA/GTATTA 2 -- int10--------
rs102466401,2
C--34357856(+) ttttgA/Caccat 2 -- int10--------
rs1392641791,2
--34357931(+) TGCTGA/GCTTGA 2 -- int10--------
rs1862680521,2
--34358070(+) ACAAAC/TAGAAT 2 -- int10--------

HapMap Linkage Disequilibrium report for NPSR1-AS1 (34386124 - 34636124 bp, first 250kb of NPSR1-AS1)

Structural Variations
      Database of Genomic Variants (DGV) variations for NPSR1-AS1: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing NPSR1-AS1
DNA2.0 Custom Variant and Variant Library Synthesis for NPSR1-AS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 608596    OMIM disorders: --

2 diseases for NPSR1-AS1:    About MalaCards
asthma    


NPSR1-AS1 for disorders           About GeneDecksing


Export disorders for NPSR1-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NPSR1-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NPSR1-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of a common susceptibility locus for asthma-related traits. (PubMed id 15073379)1, 3 Laitinen T....Kere J. (2004)
  2. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
  3. Replication of genetic association studies in asthma and related phenotypes. (PubMed id 20395963)1 Undarmaa S....Suzuki Y. (2010)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 404744 HGNC: 22128 AceView: AAA1 Ensembl:ENSG00000197085 euGenes: HUgn404744
ECgene: NPSR1-AS1 H-InvDB: NPSR1-AS1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NPSR1-AS1 gene:
Search GeneIP for patents involving NPSR1-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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