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Aliases for NPSR1 Gene

Aliases for NPSR1 Gene

  • Neuropeptide S Receptor 1 2 3
  • GPR154 3 4 6
  • PGR14 3 4 6
  • GPRA 3 4 6
  • G-Protein Coupled Receptor For Asthma Susceptibility 3 4
  • G-Protein Coupled Receptor PGR14 3 4
  • G-Protein Coupled Receptor 154 3 4
  • ASRT2 3 6
  • VRR1 3 6
  • Vasopressin Receptor-Related Receptor 1 3
  • G Protein-Coupled Receptor 154 2
  • Neuropeptide S Receptor 3
  • NPSR 3

External Ids for NPSR1 Gene

Previous Symbols for NPSR1 Gene

  • GPR154

Summaries for NPSR1 Gene

Entrez Gene Summary for NPSR1 Gene

  • This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for NPSR1 Gene

NPSR1 (Neuropeptide S Receptor 1) is a Protein Coding gene. Diseases associated with NPSR1 include asthma 2 and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide receptor activity and vasopressin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for NPSR1 Gene

  • G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Wiki entry for NPSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPSR1 Gene

Genomics for NPSR1 Gene

Genomic Location for NPSR1 Gene

34,658,239 bp from pter
34,878,332 bp from pter
220,094 bases
Plus strand

Genomic View for NPSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPSR1 Gene

Regulatory Elements for NPSR1 Gene

Proteins for NPSR1 Gene

  • Protein details for NPSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide S receptor
    Protein Accession:
    Secondary Accessions:
    • A2RTZ4
    • Q2XP58
    • Q56H76
    • Q56H77
    • Q56H78
    • Q6JSL4
    • Q6JSL5
    • Q6JSL6
    • Q6JSL7
    • Q6JSL8
    • Q6W5P3
    • Q6ZMB8

    Protein attributes for NPSR1 Gene

    371 amino acids
    Molecular mass:
    42687 Da
    Quaternary structure:
    No Data Available
    • Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.

    Alternative splice isoforms for NPSR1 Gene

neXtProt entry for NPSR1 Gene

Proteomics data for NPSR1 Gene at MOPED

Post-translational modifications for NPSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4

No data available for DME Specific Peptides for NPSR1 Gene

Domains for NPSR1 Gene

Gene Families for NPSR1 Gene

  • NPSR :GPCR / Class A : Neuropeptide receptors : S

Protein Domains for NPSR1 Gene

Suggested Antigen Peptide Sequences for NPSR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.:
    • Q6W5P4
genes like me logo Genes that share domains with NPSR1: view

Function for NPSR1 Gene

Molecular function for NPSR1 Gene

UniProtKB/Swiss-Prot Function: G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Ontology (GO) - Molecular Function for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005000 vasopressin receptor activity IEA --
GO:0008188 neuropeptide receptor activity IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view
genes like me logo Genes that share phenotypes with NPSR1: view

Animal Models for NPSR1 Gene

MGI Knock Outs for NPSR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NPSR1 Gene

Localization for NPSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPSR1 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 3: Cell membrane; Multi-pass membrane protein.
Isoform 4: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.
Isoform 9: Cytoplasm.

Subcellular locations from

Jensen Localization Image for NPSR1 Gene COMPARTMENTS Subcellular localization image for NPSR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 15947423
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPSR1: view

Pathways for NPSR1 Gene

genes like me logo Genes that share pathways with NPSR1: view

Interacting Proteins for NPSR1 Gene

Gene Ontology (GO) - Biological Process for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view

Compounds for NPSR1 Gene

(1) HMDB Compounds for NPSR1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-(Phenylalanine)-8-lysine oxytocin

(1) Drugbank Compounds for NPSR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target other/unknown

(6) IUPHAR Ligand for NPSR1 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]Tyr10NPS (human) Agonist Full agonist 9.5
neuropeptide S Agonist Full agonist 8.5
neuropeptide S Agonist Full agonist 8.5
neuropeptide S Agonist Full agonist 8.5
QA1 Antagonist Antagonist 8
PI1 Antagonist Antagonist 7.3

(1) Novoseek inferred chemical compound relationships for NPSR1 Gene

Compound -log(P) Hits PubMed IDs
methacholine 39.6 4
genes like me logo Genes that share compounds with NPSR1: view

Transcripts for NPSR1 Gene

Unigene Clusters for NPSR1 Gene

Neuropeptide S receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for NPSR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPSR1 Gene

mRNA expression in normal human tissues for NPSR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPSR1 Gene

This gene is overexpressed in Brain - Hypothalamus (15.9), Brain - Hippocampus (6.4), and Brain - Substantia nigra (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPSR1 Gene

SOURCE GeneReport for Unigene cluster for NPSR1 Gene Hs.652373

mRNA Expression by UniProt/SwissProt for NPSR1 Gene

Tissue specificity: Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.
genes like me logo Genes that share expressions with NPSR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NPSR1 Gene

Orthologs for NPSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPSR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPSR1 35
  • 99.01 (n)
  • 98.92 (a)
NPSR1 36
  • 88 (a)
(Bos Taurus)
Mammalia NPSR1 35
  • 90.72 (n)
  • 90.54 (a)
NPSR1 36
  • 85 (a)
(Canis familiaris)
Mammalia NPSR1 35
  • 88.14 (n)
  • 88.95 (a)
NPSR1 36
  • 79 (a)
(Mus musculus)
Mammalia Npsr1 35
  • 86.61 (n)
  • 89.22 (a)
Npsr1 16
Npsr1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia NPSR1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia NPSR1 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Npsr1 35
  • 86.88 (n)
  • 89.22 (a)
(Gallus gallus)
Aves NPSR1 35
  • 74.39 (n)
  • 76.82 (a)
NPSR1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia NPSR1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npsr1 35
  • 68.19 (n)
  • 71.65 (a)
(Danio rerio)
Actinopterygii gnrhr1 36
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRVPR1 35
  • 50.36 (n)
  • 43.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CcapR 35
  • 52.81 (n)
  • 43.56 (a)
CcapR 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea ntr-1 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for NPSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPSR1 Gene

Gene Tree for NPSR1 (if available)
Gene Tree for NPSR1 (if available)

Paralogs for NPSR1 Gene

Paralogs for NPSR1 Gene

Selected SIMAP similar genes for NPSR1 Gene using alignment to 2 proteins: Pseudogenes for NPSR1 Gene

genes like me logo Genes that share paralogs with NPSR1: view

Variants for NPSR1 Gene

Sequence variations from dbSNP and Humsavar for NPSR1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs740717 -- 34,839,698(+) cattg(C/T)tccac intron-variant
rs740718 -- 34,839,856(+) TTGGG(G/T)TGGTA intron-variant
rs1419867 -- 34,855,329(+) GAAAA(A/T)AATTA intron-variant
rs1592418 -- 34,871,731(+) tcatc(A/G)cgttt intron-variant
rs1592441 -- 34,855,914(+) TATAT(A/T)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPSR1 Gene

Variant ID Type Subtype PubMed ID
dgv1127e201 CNV Deletion 23290073
nsv436907 CNV Insertion 17901297
nsv887931 CNV Loss 21882294
nsv818494 CNV Loss 17921354
nsv887932 CNV Loss 21882294
nsv523149 CNV Loss 19592680
nsv523190 CNV Gain 19592680
nsv517860 CNV Loss 19592680
dgv7246n71 CNV Loss 21882294
dgv7247n71 CNV Loss 21882294
nsv819499 CNV Loss 19587683
nsv887939 CNV Loss 21882294
nsv887940 CNV Loss 21882294
nsv887941 CNV Loss 21882294
nsv887942 CNV Loss 21882294
nsv887943 CNV Loss 21882294
nsv887944 CNV Gain 21882294
nsv887945 CNV Loss 21882294
nsv887946 CNV Loss 21882294
nsv887947 CNV Loss 21882294
dgv7248n71 CNV Loss 21882294
nsv887950 CNV Gain 21882294
dgv418n21 CNV Loss 19592680
esv2668941 CNV Deletion 23128226
esv25996 CNV Loss 19812545
nsv818495 CNV Loss 17921354
esv2421641 CNV Deletion 20811451
nsv442038 CNV CNV 18776908

Relevant External Links for NPSR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPSR1 Gene

Disorders for NPSR1 Gene

(1) OMIM Diseases for NPSR1 Gene (608595)


  • Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15073379, ECO:0000269 PubMed:15710598, ECO:0000269 PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) MalaCards Diseases for NPSR1 Gene

Search for NPSR1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for NPSR1 Gene

(2) Novoseek inferred disease relationships for NPSR1 Gene

Disease -log(P) Hits PubMed IDs
asthma 62.5 25
asthma allergic 60.1 2

Relevant External Links for NPSR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPSR1: view

Publications for NPSR1 Gene

  1. Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma. (PMID: 15710598) Melen E. … Nyberg F. (Am. J. Respir. Crit. Care Med. 2005) 3 4 23
  2. Characterization of GPRA, a novel G protein-coupled receptor related to asthma. (PMID: 15947423) Vendelin J. … Laitinen T. (Am. J. Respir. Cell Mol. Biol. 2005) 3 4 23
  3. G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population. (PMID: 16522461) Feng Y. … Xu X. (J. Allergy Clin. Immunol. 2006) 3 23 48
  4. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PMID: 16790440) Bernier V. … Therien A.G. (J. Biol. Chem. 2006) 3 4 23
  5. Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma. (PMID: 17210045) Malerba G. … Pignatti P.F. (Clin. Exp. Allergy 2007) 3 23 48

Products for NPSR1 Gene

Sources for NPSR1 Gene

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