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Aliases for NPSR1 Gene

Aliases for NPSR1 Gene

  • Neuropeptide S Receptor 1 2 3
  • G-Protein Coupled Receptor For Asthma Susceptibility 3 4
  • G-Protein Coupled Receptor PGR14 3 4
  • G-Protein Coupled Receptor 154 3 4
  • GPR154 3 4
  • PGR14 3 4
  • GPRA 3 4
  • Vasopressin Receptor-Related Receptor 1 3
  • G Protein-Coupled Receptor 154 2
  • ASRT2 3
  • NPSR 3
  • VRR1 3

External Ids for NPSR1 Gene

Previous HGNC Symbols for NPSR1 Gene

  • GPR154

Summaries for NPSR1 Gene

Entrez Gene Summary for NPSR1 Gene

  • This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for NPSR1 Gene

NPSR1 (Neuropeptide S Receptor 1) is a Protein Coding gene. Diseases associated with NPSR1 include asthma 2 and bronchial disease. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and vasopressin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for NPSR1 Gene

  • G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Wiki entry for NPSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPSR1 Gene

Genomics for NPSR1 Gene

Regulatory Elements for NPSR1 Gene

Genomic Location for NPSR1 Gene

Chromosome:
7
Start:
34,658,239 bp from pter
End:
34,878,332 bp from pter
Size:
220,094 bases
Orientation:
Plus strand

Genomic View for NPSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPSR1 Gene

Proteins for NPSR1 Gene

  • Protein details for NPSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6W5P4-NPSR1_HUMAN
    Recommended name:
    Neuropeptide S receptor
    Protein Accession:
    Q6W5P4
    Secondary Accessions:
    • A2RTZ4
    • Q2XP58
    • Q56H76
    • Q56H77
    • Q56H78
    • Q6JSL4
    • Q6JSL5
    • Q6JSL6
    • Q6JSL7
    • Q6JSL8
    • Q6W5P3
    • Q6ZMB8

    Protein attributes for NPSR1 Gene

    Size:
    371 amino acids
    Molecular mass:
    42687 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.

    Alternative splice isoforms for NPSR1 Gene

neXtProt entry for NPSR1 Gene

Proteomics data for NPSR1 Gene at MOPED

Post-translational modifications for NPSR1 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NPSR1 Gene

Domains & Families for NPSR1 Gene

Gene Families for NPSR1 Gene

Protein Domains for NPSR1 Gene

Suggested Antigen Peptide Sequences for NPSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6W5P4

UniProtKB/Swiss-Prot:

NPSR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with NPSR1: view

Function for NPSR1 Gene

Molecular function for NPSR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Ontology (GO) - Molecular Function for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005000 vasopressin receptor activity IEA --
GO:0008188 neuropeptide receptor activity IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view

Phenotypes for NPSR1 Gene

genes like me logo Genes that share phenotypes with NPSR1: view

Animal Models for NPSR1 Gene

MGI Knock Outs for NPSR1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NPSR1 Gene

Localization for NPSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPSR1 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 3: Cell membrane; Multi-pass membrane protein.
Isoform 4: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.
Isoform 9: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPSR1 Gene COMPARTMENTS Subcellular localization image for NPSR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 15947423
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPSR1: view

Pathways & Interactions for NPSR1 Gene

genes like me logo Genes that share pathways with NPSR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NPSR1 Gene

Gene Ontology (GO) - Biological Process for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0042755 eating behavior IEA --
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 16790440
GO:0060013 righting reflex IEA --
genes like me logo Genes that share ontologies with NPSR1: view

No data available for SIGNOR curated interactions for NPSR1 Gene

Drugs & Compounds for NPSR1 Gene

(7) Drugs for NPSR1 Gene - From: IUPHAR, DGIdb, HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved Pharma Activator, Target, other/unknown 1
Vasopressin Approved Pharma Partial agonist, Agonist 0
methacholine Approved Pharma 0
[<sup>125</sup>I]Tyr<sup>10</sup>NPS (human) Pharma Full agonist, Agonist 0
neuropeptide S Pharma Full agonist, Agonist 0

(1) Additional Compounds for NPSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Kyselina trifluoroctova
  • Perfluoroacetic acid
  • Trifluoracetic acid
76-05-1
genes like me logo Genes that share compounds with NPSR1: view

Transcripts for NPSR1 Gene

Unigene Clusters for NPSR1 Gene

Neuropeptide S receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for NPSR1 Gene

GeneLoc Exon Structure for
NPSR1
ECgene alternative splicing isoforms for
NPSR1

Expression for NPSR1 Gene

mRNA expression in normal human tissues for NPSR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPSR1 Gene

This gene is overexpressed in Brain - Hypothalamus (x15.9), Brain - Hippocampus (x6.4), and Brain - Substantia nigra (x4.2).

SOURCE GeneReport for Unigene cluster for NPSR1 Gene Hs.652373

mRNA Expression by UniProt/SwissProt for NPSR1 Gene

Q6W5P4-NPSR1_HUMAN
Tissue specificity: Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.
genes like me logo Genes that share expression patterns with NPSR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPSR1 Gene

Orthologs for NPSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPSR1 35
  • 90.72 (n)
  • 90.54 (a)
NPSR1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPSR1 35
  • 88.14 (n)
  • 88.95 (a)
NPSR1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npsr1 35
  • 86.61 (n)
  • 89.22 (a)
Npsr1 16
Npsr1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPSR1 35
  • 99.01 (n)
  • 98.92 (a)
NPSR1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npsr1 35
  • 86.88 (n)
  • 89.22 (a)
oppossum
(Monodelphis domestica)
Mammalia NPSR1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPSR1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPSR1 35
  • 74.39 (n)
  • 76.82 (a)
NPSR1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPSR1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npsr1 35
  • 68.19 (n)
  • 71.65 (a)
zebrafish
(Danio rerio)
Actinopterygii gnrhr1 36
  • 24 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRVPR1 35
  • 50.36 (n)
  • 43.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CcapR 35
  • 52.81 (n)
  • 43.56 (a)
CcapR 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ntr-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for NPSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPSR1 Gene

ENSEMBL:
Gene Tree for NPSR1 (if available)
TreeFam:
Gene Tree for NPSR1 (if available)

Paralogs for NPSR1 Gene

Paralogs for NPSR1 Gene

(4) SIMAP similar genes for NPSR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NPSR1 Gene

genes like me logo Genes that share paralogs with NPSR1: view

Variants for NPSR1 Gene

Sequence variations from dbSNP and Humsavar for NPSR1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs740717 -- 34,839,698(+) cattg(C/T)tccac intron-variant
rs740718 -- 34,839,856(+) TTGGG(G/T)TGGTA intron-variant
rs1419867 -- 34,855,329(+) GAAAA(A/T)AATTA intron-variant
rs1592418 -- 34,871,731(+) tcatc(A/G)cgttt intron-variant
rs1592441 -- 34,855,914(+) TATAT(A/T)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPSR1 Gene

Variant ID Type Subtype PubMed ID
dgv1127e201 CNV Deletion 23290073
nsv436907 CNV Insertion 17901297
nsv887931 CNV Loss 21882294
nsv818494 CNV Loss 17921354
nsv887932 CNV Loss 21882294
nsv523149 CNV Loss 19592680
nsv523190 CNV Gain 19592680
nsv517860 CNV Loss 19592680
dgv7246n71 CNV Loss 21882294
dgv7247n71 CNV Loss 21882294
nsv819499 CNV Loss 19587683
nsv887939 CNV Loss 21882294
nsv887940 CNV Loss 21882294
nsv887941 CNV Loss 21882294
nsv887942 CNV Loss 21882294
nsv887943 CNV Loss 21882294
nsv887944 CNV Gain 21882294
nsv887945 CNV Loss 21882294
nsv887946 CNV Loss 21882294
nsv887947 CNV Loss 21882294
dgv7248n71 CNV Loss 21882294
nsv887950 CNV Gain 21882294
dgv418n21 CNV Loss 19592680
esv2668941 CNV Deletion 23128226
esv25996 CNV Loss 19812545
nsv818495 CNV Loss 17921354
esv2421641 CNV Deletion 20811451
nsv442038 CNV CNV 18776908

Variation tolerance for NPSR1 Gene

Residual Variation Intolerance Score: 97.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.62; 96.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPSR1 Gene

HapMap Linkage Disequilibrium report
NPSR1
Human Gene Mutation Database (HGMD)
NPSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPSR1 Gene

Disorders for NPSR1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for NPSR1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
asthma 2
  • asthma, susceptibility to, 2
bronchial disease
  • bronchial disorder
asthma
  • asthma, protection against
atopy
  • ige responsiveness, atopic
respiratory system disease
  • respiration disorders
- elite association
Search NPSR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NPSR1_HUMAN
  • Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15073379, ECO:0000269 PubMed:15710598, ECO:0000269 PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for NPSR1

Genetic Association Database (GAD)
NPSR1
Human Genome Epidemiology (HuGE) Navigator
NPSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPSR1
genes like me logo Genes that share disorders with NPSR1: view

No data available for Genatlas for NPSR1 Gene

Publications for NPSR1 Gene

  1. Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function. (PMID: 19874863) Clark S.D. … Reinscheid R.K. (Peptides 2010) 23 67
  2. Molecular modeling studies on the human neuropeptide S receptor and its antagonists. (PMID: 20087922) Dal Ben D. … Cristalli G. (ChemMedChem 2010) 23 67
  3. Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders. (PMID: 19732772) Camilleri M. … D'Amato M. (Gastroenterology 2010) 23 67
  4. Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor. (PMID: 20307531) Nepomuceno D. … Bonaventure P. (Eur. J. Pharmacol. 2010) 23 67
  5. Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists. (PMID: 19113861) Guerrini R. … Salvadori S. (J. Med. Chem. 2009) 23 67

Products for NPSR1 Gene

Sources for NPSR1 Gene

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