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Aliases for NPSR1 Gene

Aliases for NPSR1 Gene

  • Neuropeptide S Receptor 1 2 3 5
  • G-Protein Coupled Receptor For Asthma Susceptibility 3 4
  • G-Protein Coupled Receptor PGR14 3 4
  • G-Protein Coupled Receptor 154 3 4
  • GPR154 3 4
  • PGR14 3 4
  • GPRA 3 4
  • Vasopressin Receptor-Related Receptor 1 3
  • G Protein-Coupled Receptor 154 2
  • Neuropeptide S Receptor 3
  • ASRT2 3
  • NPSR 3
  • VRR1 3

External Ids for NPSR1 Gene

Previous HGNC Symbols for NPSR1 Gene

  • GPR154

Summaries for NPSR1 Gene

Entrez Gene Summary for NPSR1 Gene

  • This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for NPSR1 Gene

NPSR1 (Neuropeptide S Receptor 1) is a Protein Coding gene. Diseases associated with NPSR1 include Asthma 2 and Asthma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and vasopressin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for NPSR1 Gene

  • G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Wiki entry for NPSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPSR1 Gene

Genomics for NPSR1 Gene

Regulatory Elements for NPSR1 Gene

Enhancers for NPSR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F034747 1.3 Ensembl ENCODE 10.8 +90.4 90358 2.7 PKNOX1 ATF1 MLX ARID4B ZNF48 ZNF2 SLC30A9 ZNF143 FOS ZNF263 NPSR1 DPY19L1 NCAPD2P1 RPL7P31
GH07F034754 1.2 FANTOM5 ENCODE 10.4 +99.1 99140 4.8 ELF3 TBP PKNOX1 ARID4B YBX1 BMI1 RAD21 ZBTB40 RARA ZNF143 NPSR1 RN7SL132P GC07P034789
GH07F034750 0.7 ENCODE 10.3 +93.8 93764 3.8 SOX5 DRAP1 TEAD1 HBP1 TEAD3 RELA HNF1A CREM ZNF652 MAFK NPSR1 NCAPD2P1 RPL7P31
GH07F034839 0.6 ENCODE 10.5 +182.0 181979 1.2 ESRRA HCFC1 SIX5 USF2 CTBP1 RAD51 ZNF143 THAP11 NPSR1 GC07P034858 GC07P034789
GH07F034612 0.4 ENCODE 10.9 -45.3 -45294 1.1 GATAD2A TEAD4 NPSR1 GC07M034599 RNU6-438P GC07M034297
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPSR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPSR1 Gene

Chromosome:
7
Start:
34,658,239 bp from pter
End:
34,878,332 bp from pter
Size:
220,094 bases
Orientation:
Plus strand

Genomic View for NPSR1 Gene

Genes around NPSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPSR1 Gene

Proteins for NPSR1 Gene

  • Protein details for NPSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6W5P4-NPSR1_HUMAN
    Recommended name:
    Neuropeptide S receptor
    Protein Accession:
    Q6W5P4
    Secondary Accessions:
    • A2RTZ4
    • Q2XP58
    • Q56H76
    • Q56H77
    • Q56H78
    • Q6JSL4
    • Q6JSL5
    • Q6JSL6
    • Q6JSL7
    • Q6JSL8
    • Q6W5P3
    • Q6ZMB8

    Protein attributes for NPSR1 Gene

    Size:
    371 amino acids
    Molecular mass:
    42687 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.

    Alternative splice isoforms for NPSR1 Gene

neXtProt entry for NPSR1 Gene

Post-translational modifications for NPSR1 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPSR1 Gene

Domains & Families for NPSR1 Gene

Gene Families for NPSR1 Gene

Protein Domains for NPSR1 Gene

Suggested Antigen Peptide Sequences for NPSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6W5P4

UniProtKB/Swiss-Prot:

NPSR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with NPSR1: view

Function for NPSR1 Gene

Molecular function for NPSR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

Gene Ontology (GO) - Molecular Function for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005000 vasopressin receptor activity IEA --
GO:0008188 neuropeptide receptor activity IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view

Phenotypes for NPSR1 Gene

genes like me logo Genes that share phenotypes with NPSR1: view

Animal Models for NPSR1 Gene

MGI Knock Outs for NPSR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPSR1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPSR1 Gene

Localization for NPSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPSR1 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 3: Cell membrane; Multi-pass membrane protein.
Isoform 4: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.
Isoform 9: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPSR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 16790440
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPSR1: view

Pathways & Interactions for NPSR1 Gene

genes like me logo Genes that share pathways with NPSR1: view

Interacting Proteins for NPSR1 Gene

Gene Ontology (GO) - Biological Process for NPSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 16790440
genes like me logo Genes that share ontologies with NPSR1: view

No data available for SIGNOR curated interactions for NPSR1 Gene

Drugs & Compounds for NPSR1 Gene

(7) Drugs for NPSR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, Target, other/unknown 2
Vasopressin Approved Pharma Full agonist, Agonist 0
[<sup>125</sup>I]Tyr<sup>10</sup>NPS (human) Pharma Full agonist, Agonist 0
neuropeptide S Pharma Full agonist, Agonist 0
PI1 Pharma Antagonist 0

(1) Additional Compounds for NPSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Kyselina trifluoroctova
  • Perfluoroacetic acid
  • Trifluoracetic acid
76-05-1
genes like me logo Genes that share compounds with NPSR1: view

Transcripts for NPSR1 Gene

Unigene Clusters for NPSR1 Gene

Neuropeptide S receptor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for NPSR1 Gene

GeneLoc Exon Structure for
NPSR1
ECgene alternative splicing isoforms for
NPSR1

Expression for NPSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPSR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPSR1 Gene

This gene is overexpressed in Brain - Hypothalamus (x15.9), Brain - Hippocampus (x6.4), and Brain - Substantia nigra (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of NPSR1 Gene:

NPSR1

SOURCE GeneReport for Unigene cluster for NPSR1 Gene:

Hs.652373

mRNA Expression by UniProt/SwissProt for NPSR1 Gene:

Q6W5P4-NPSR1_HUMAN
Tissue specificity: Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.
genes like me logo Genes that share expression patterns with NPSR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPSR1 Gene

Orthologs for NPSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPSR1 34 35
  • 99.01 (n)
cow
(Bos Taurus)
Mammalia NPSR1 34 35
  • 90.72 (n)
dog
(Canis familiaris)
Mammalia NPSR1 34 35
  • 88.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPSR1 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npsr1 34
  • 86.88 (n)
mouse
(Mus musculus)
Mammalia Npsr1 34 16 35
  • 86.61 (n)
oppossum
(Monodelphis domestica)
Mammalia NPSR1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPSR1 34 35
  • 74.39 (n)
lizard
(Anolis carolinensis)
Reptilia NPSR1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npsr1 34
  • 68.19 (n)
zebrafish
(Danio rerio)
Actinopterygii gnrhr1 35
  • 24 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CcapR 34 35
  • 52.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRVPR1 34
  • 50.36 (n)
worm
(Caenorhabditis elegans)
Secernentea ntr-1 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for NPSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPSR1 Gene

ENSEMBL:
Gene Tree for NPSR1 (if available)
TreeFam:
Gene Tree for NPSR1 (if available)

Paralogs for NPSR1 Gene

Paralogs for NPSR1 Gene

(4) SIMAP similar genes for NPSR1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NPSR1 Gene

genes like me logo Genes that share paralogs with NPSR1: view

Variants for NPSR1 Gene

Sequence variations from dbSNP and Humsavar for NPSR1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs324981 other 34,778,501(+) TATTA(A/T)TTGGC intron-variant, reference, missense
rs10081183 -- 34,700,601(+) ATTCC(A/C)CTATA intron-variant
rs10081224 -- 34,702,981(+) CTACA(G/T)AATCA intron-variant
rs10081225 -- 34,703,074(+) AAAAG(A/G)AGCGG intron-variant
rs1013126 -- 34,666,999(+) TAATT(C/T)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPSR1 Gene

Variant ID Type Subtype PubMed ID
nsv971552 CNV duplication 23825009
nsv970812 CNV duplication 23825009
nsv970458 CNV duplication 23825009
nsv819499 CNV loss 19587683
nsv818495 CNV loss 17921354
nsv818494 CNV loss 17921354
nsv606616 CNV loss 21841781
nsv606615 CNV loss 21841781
nsv523190 CNV gain 19592680
nsv523149 CNV loss 19592680
nsv517860 CNV loss 19592680
nsv442038 CNV loss 18776908
nsv436907 CNV insertion 17901297
nsv1135982 CNV deletion 24896259
nsv1132048 CNV deletion 24896259
nsv1132047 CNV deletion 24896259
nsv1075024 CNV deletion 25765185
nsv1020423 CNV gain 25217958
esv3612805 CNV loss 21293372
esv3612750 OTHER inversion 21293372
esv3571743 CNV loss 25503493
esv3571735 CNV loss 25503493
esv2761149 CNV loss 21179565
esv2668941 CNV deletion 23128226
esv25996 CNV loss 19812545
esv2421641 CNV deletion 20811451
dgv6320n100 CNV gain 25217958
dgv418n21 CNV loss 19592680
dgv1884e212 CNV loss 25503493
dgv1883e212 CNV loss 25503493
dgv1080e201 CNV deletion 23290073

Variation tolerance for NPSR1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.62; 96.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPSR1 Gene

Human Gene Mutation Database (HGMD)
NPSR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPSR1 Gene

Disorders for NPSR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NPSR1 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma 2
  • asthma-related traits 2
asthma
  • asthma, protection against
allergic asthma
  • atopic asthma
atopy
  • atopic hypersensitivity
dermatitis
  • eczema
- elite association - COSMIC cancer census association via MalaCards
Search NPSR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NPSR1_HUMAN
  • Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:15073379, ECO:0000269 PubMed:15710598, ECO:0000269 PubMed:15764725}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for NPSR1

Genetic Association Database (GAD)
NPSR1
Human Genome Epidemiology (HuGE) Navigator
NPSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPSR1
genes like me logo Genes that share disorders with NPSR1: view

No data available for Genatlas for NPSR1 Gene

Publications for NPSR1 Gene

  1. Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders. (PMID: 19732772) Camilleri M. … D'Amato M. (Gastroenterology 2010) 3 22 46 64
  2. Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases. (PMID: 18305139) Orsmark-Pietras C. … Kere J. (Hum. Mol. Genet. 2008) 3 22 46 64
  3. Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. (PMID: 18340359) Wu H. … London S.J. (Genes Immun. 2008) 3 22 46 64
  4. Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma. (PMID: 17210045) Malerba G. … Pignatti P.F. (Clin. Exp. Allergy 2007) 3 22 46 64
  5. [Study on the association of single nucleotide polymorphisms and haplotypes of GPR154 gene with allergic asthma in Han nationality in Hubei Chinese population]. (PMID: 17285544) Zhu H.Y. … Cui T.P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 22 46 64

Products for NPSR1 Gene

Sources for NPSR1 Gene

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