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Aliases for NPS Gene

Aliases for NPS Gene

  • Neuropeptide S 2 3
  • Prepro-Neuropeptide S 2

External Ids for NPS Gene

Summaries for NPS Gene

GeneCards Summary for NPS Gene

NPS (Neuropeptide S) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR.

UniProtKB/Swiss-Prot for NPS Gene

  • Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Gene Wiki entry for NPS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPS Gene

Genomics for NPS Gene

Genomic Location for NPS Gene

Start:
127,549,349 bp from pter
End:
127,552,671 bp from pter
Size:
3,323 bases
Orientation:
Plus strand

Genomic View for NPS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPS Gene

Regulatory Elements for NPS Gene

Proteins for NPS Gene

  • Protein details for NPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0P6-NPS_HUMAN
    Recommended name:
    Neuropeptide S
    Protein Accession:
    P0C0P6
    Secondary Accessions:

    Protein attributes for NPS Gene

    Size:
    89 amino acids
    Molecular mass:
    10103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPS Gene

Proteomics data for NPS Gene at MOPED

Post-translational modifications for NPS Gene

No Post-translational modifications

Other Protein References for NPS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPS Gene

Domains for NPS Gene

Gene Families for NPS Gene

HGNC:

Protein Domains for NPS Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with NPS: view

No data available for UniProtKB/Swiss-Prot for NPS Gene

Function for NPS Gene

Molecular function for NPS Gene

UniProtKB/Swiss-Prot Function: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPS Gene

Localization for NPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPS Gene COMPARTMENTS Subcellular localization image for NPS gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPS: view

Pathways for NPS Gene

genes like me logo Genes that share pathways with NPS: view

Interacting Proteins for NPS Gene

Gene Ontology (GO) - Biological Process for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008542 visual learning IEA --
GO:0032230 positive regulation of synaptic transmission, GABAergic IEA --
GO:0045760 positive regulation of action potential IEA --
GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA --
genes like me logo Genes that share ontologies with NPS: view

Transcripts for NPS Gene

mRNA/cDNA for NPS Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPS Gene

No ASD Table

Relevant External Links for NPS Gene

GeneLoc Exon Structure for
NPS
ECgene alternative splicing isoforms for
NPS

Expression for NPS Gene

mRNA expression in normal human tissues for NPS Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPS Gene

SOURCE GeneReport for Unigene cluster for NPS Gene Hs.643423

genes like me logo Genes that share expressions with NPS: view

Orthologs for NPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPS 36
  • 98.13 (n)
  • 95.51 (a)
NPS 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPS 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nps 36
  • 81.44 (n)
  • 73.86 (a)
Nps 16
Nps 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPS 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nps 36
  • 82.58 (n)
  • 73.86 (a)
lizard
(Anolis carolinensis)
Reptilia NPS 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nps 36
  • 60.85 (n)
  • 61.63 (a)
Species with no ortholog for NPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPS Gene

ENSEMBL:
Gene Tree for NPS (if available)
TreeFam:
Gene Tree for NPS (if available)

Paralogs for NPS Gene

No data available for Paralogs for NPS Gene

Variants for NPS Gene

Sequence variations from dbSNP and Humsavar for NPS Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs990310 - 127,549,521(+) TCTGT(C/T)GCTGT reference, missense
rs990311 -- 127,549,985(+) GTTAG(A/C)TCTAA intron-variant
rs995202 -- 127,551,661(+) TTTGC(A/C)TTATT intron-variant
rs1931706 -- 127,547,935(+) TAATC(C/T)TGTGA upstream-variant-2KB
rs1931707 -- 127,548,093(+) AGACA(C/G)AGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPS Gene

Variant ID Type Subtype PubMed ID
nsv7607 CNV Loss 18451855

Relevant External Links for NPS Gene

HapMap Linkage Disequilibrium report
NPS
Human Gene Mutation Database (HGMD)
NPS

Disorders for NPS Gene

Relevant External Links for NPS

Genetic Association Database (GAD)
NPS
Human Genome Epidemiology (HuGE) Navigator
NPS
genes like me logo Genes that share disorders with NPS: view

No data available for UniProtKB/Swiss-Prot for NPS Gene

Publications for NPS Gene

  1. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu Y.-L. … Civelli O. (Neuron 2004) 2 3 4
  2. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PMID: 16790440) Bernier V. … Therien A.G. (J. Biol. Chem. 2006) 3 4
  3. Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V. … Salvadori S. (J. Med. Chem. 2008) 2 3
  4. Assessment of the neuropeptide S system in anxiety disorders. (PMID: 20705147) Donner J. … Hovatta I. (Biol. Psychiatry 2010) 3 49
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49

Products for NPS Gene

Sources for NPS Gene

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