NPS Gene
protein-coding GIFtS: 37
GCID: GC10P129347
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neuropeptide S
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Aliases
for NPS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Export aliases for NPS gene to outside databasesPrevious GC identifers: GC10U900621 GC10P129237 GC10P122920 |
Summaries
for NPS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 withnanomolar affinity to increase intracellular calcium concentrations (By similarity)
Gene Wiki entry for NPS (Neuropeptide S)
|
Genomic Views
for NPS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPS gene promoter:
TBP C/EBPbeta HOXA3 CUTL1 FOXL1 Pax-3 S8 FOXO1a Cart-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2NPS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P129347: view genomic region
(about GC identifiers)
Start:
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129,347,613 bp from pter |
End:
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129,350,935 bp from pter |
Size:
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3,323 bases |
Orientation:
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plus strand |
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Proteins
for NPS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6 (See
protein sequence)Recommended Name: Neuropeptide S precursor Size: 89 amino acids; 10103 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for NPS: NX_P0C0P6
NPS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025184.1
ENSEMBL proteins: ENSP00000381105 Reactome Protein details: P0C0P6
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
NPS for ontologies About GeneDecksing
NPS Antibody Products:
Assay Products for NPS: |
Protein
Domains /
Families
for NPS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P0C0P6 |
Function
for NPS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 withnanomolar affinity to increase intracellular calcium concentrations (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NPS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPS |
|
Pathways & Interactions
for NPS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for NPS (see all 9)
NPS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/183 Interacting proteins for NPS (ENSP000003811054) via UniProtKB, MINT, STRING, and/or I2D (see all 183)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
IEA | -- | | GO:0008542 | visual learning |
IEA | -- | | GO:0032230 | positive regulation of synaptic transmission, GABAergic |
IEA | -- | | GO:0045760 | positive regulation of action potential |
IEA | -- | | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
IEA | -- |
NPS for ontologies About GeneDecksing
|
Drugs & Compounds
for NPS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPS
Search CenterWatch for drugs/clinical trials and news about NPS
|
Transcripts
for NPS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPS gene: NM_001030013.1 Unigene Cluster for NPS: Neuropeptide S Hs.643423 Unigene Representative Sequence: NM_0010300131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000398023(uc001ljx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NPS (NM_080594) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPS |
GeneLoc Exon Structure
|
Expression
for NPS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAAGTGTG
About this image
See NPS Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.643423
SABiosciences Custom PCR Arrays for NPS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPS |
Orthologs
for NPS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NPS gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for NPS (if available)
TreeFam Gene Tree for NPS (if available) |
Paralogs
for NPS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NPS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPS (129347613 - 129350935 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NPS: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPS |
|
Disorders
/ Diseases
for NPS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPS for disorders About GeneDecksing
OMIM gene information: 609513
OMIM disorders: --
16  diseases for NPS: About MalaCardspthirus pubis infestation leber hereditary optic neuropathy mitochondrial encephalomyopathy sleep apnea
anorexia nervosa gastrointestinal system disease optic atrophy wolfram syndrome
apnea encephalomyopathy skin disease rhinitis
dementia neuropathy asthma arthritis
2 diseases from the University of Copenhagen DISEASES database for NPS:Leber hereditary optic neuropathy Optic atrophy Human Genome Epidemiology (HuGE) Navigator: NPS (18 documents)
Export disorders for NPS gene to outside databases
|
Publications
for NPS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPS gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NPS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PubMed id 15312648)1, 2, 3 Xu Y.L....Civelli O. (2004)
- Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PubMed id 18181564)1, 3 Camarda V....Salvadori S. (2008)
- Neurobiology, pharmacology, and medicinal chemistry o f neuropeptide S and its receptor. (PubMed id 19824051)1 Guerrini R....Calo' G. (2010)
- Non-synonymous polymorphism in the neuropeptide S pre cursor gene and sleep apnea. (PubMed id 20405330)1 SA!nchez-de-la-Torre M....BarbAc F. (2010)
- Assessment of the neuropeptide S system in anxiety di sorders. (PubMed id 20705147)1 Donner J....Hovatta I. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. (PubMed id 18376418)1 Rizzi A....Calo G. (2008)
- Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)1 Vendelin J....Kere J. (2006)
- Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation. (PubMed id 16720571)1 Roth A.L....Guerrini R. (2006)
- Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. (PubMed id 16574794)1 Smith K.L....Bloom S.R. (2006)
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External Searches for NPS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NPS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPS gene:
Search GeneIP for patents involving NPS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPS | | | OriGene Protein Over-expression Lysate for NPS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPS | | OriGene Custom Protein Services for NPS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPS |
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| | | | Search Tocris compounds for NPS |
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 | | | NPS Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for NPS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPS |
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