NPS Gene

Aliases
for NPS gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC10U900621 GC10P129237 GC10P122920

Summaries
for NPS gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for NPS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000010.10  NC_018921.2  NT_030059.14  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPS

NPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P129347:  view genomic region     (about GC identifiers)

Proteins
for NPS gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for NPS: NX_P0C0P6

Explore proteomics data for NPS at MOPED


See NPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

NPS Human Recombinant Protein Products:

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	Search GeneTex for Proteins for NPS
	antibodies-online proteins for NPS (3 products)
	antibodies-online peptides for NPS

NPS Antibody Products:

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	antibodies-online antibodies for NPS (55 products)

NPS Assay Products:

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	Cloud-Clone Corp. ELISAs for NPS Cloud-Clone Corp. CLIAs for NPS
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	antibodies-online kits for NPS (12 products)

Domains /
Families
for NPS gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P0C0P6

Function
for NPS gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for NPS

miRNA Products:		Block miRNA regulation of human, mouse, rat NPS using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate NPS
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NPS
		Predesigned siRNA for gene silencing in human, mouse, rat NPS

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NPS

Clone Products:		OriGene clones in human, mouse for NPS (see all 5) OriGene ORF clones in mouse, rat for NPS OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NPS (NM_080594)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NPS
		Browse ESI BIO Cell Lines and PureStem Progenitors for NPS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPS

Localization
for NPS gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
nucleus	3
cytoskeleton	2
endoplasmic reticulum	2
golgi apparatus	2
mitochondrion	2
plasma membrane	2
cytosol	1
endosome	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for NPS gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for NPS About     See pathways by source

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	SuperPath	Contained pathways About
1	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90
2	Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) 0.71 Peptide ligand-binding receptors 0.60 GPCR ligand binding 0.71
3	Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events 0.90 Gastrin-CREB signalling pathway via PKC and MAPK 0.90
4	G alpha (s) signalling events	G alpha (s) signalling events

3 Reactome Pathways for NPS

	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (s) signalling events

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for NPS gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for NPS gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for NPS gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTAAGTGTG

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for NPS OriGene qSTAR qPCR primer pairs in human, mouse for NPS
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPS
		QuantiTect SYBR Green Assays in human, mouse, rat NPS
		QuantiFast Probe-based Assays in human, mouse, rat NPS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPS

Orthologs
for NPS gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for NPS gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for NPS gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NPS (see all 186)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs591215431,2	C	--	122919006(+)	CCTGC-/ATGC/ATGCGT/ATGCGTGT/AT GCGTGTGTGT/ATGCGTGTGTGTGTgtgtg	3	--	us2k1 cds1		0	--	--	--	--
rs115975031,2	C,F,H	--	129345622(+)	atggcG/Acatgg	1	--	us2k1		14		NS EA NA WA CSA	627
rs1918009751,2		--	129345631(+)	GGTCCC/TAGCTA	1	--	us2k1		0	--	--	--	--
rs1500409211,2		--	129345685(+)	AGGCTA/GCAGTG	1	--	us2k1		0	--	--	--	--
rs1840120401,2		--	129345784(+)	CTCCTA/GCCAAT	1	--	us2k1		0	--	--	--	--
rs110181891,2	C,F,H	--	129345788(+)	TGCCAA/GTTCTA	1	--	us2k1		22		NS EA NA WA	2766
rs1453945201,2		--	129345871(+)	TTTCCA/GCTTAA	1	--	us2k1		0	--	--	--	--
rs1903128451,2		--	129345906(+)	CTACAG/TGCAAA	1	--	us2k1		0	--	--	--	--
rs2013427121,2		--	129346016(+)	GTTCC-/TGCA           TGCGT	1	--	us2k1		0	--	--	--	--
rs78980561,2	C	--	129346020(+)	CCtgcA/C/Gtgtgt	1	--	us2k1		2		CSA	3

HapMap Linkage Disequilibrium report for NPS (129347613 - 129350935 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for NPS:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv7607	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NPS

DNA2.0 Custom Variant and Variant Library Synthesis for NPS

Disorders / Diseases
for NPS gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for NPS gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PubMed id 15312648)^{1, 2, 3} Xu Y.-L....Civelli O. (Neuron 2004)
2. Assessment of the neuropeptide S system in anxiety disorders. (PubMed id 20705147)^{1, 4} Donner J....Hovatta I. (Biol. Psychiatry 2010)
3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
4. Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PubMed id 18181564)^{1, 3} Camarda V....Salvadori S. (J. Med. Chem. 2008)
5. Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation. (PubMed id 23142110)¹ Filaferro M....Vitale G. (Peptides 2013)
6. Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. (PubMed id 20405330)¹ SA!nchez-de-la-Torre M....BarbAc F. (amp 2011)
7. Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor. (PubMed id 19824051)¹ Guerrini R....Calo' G. (Med Res Rev 2010)
8. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)⁴ Paterson A.D....Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009)
9. Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. (PubMed id 18376418)¹ Rizzi A....Calo G. (Br. J. Pharmacol. 2008)
10. Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)¹ Vendelin J....Kere J. (Hum. Mol. Genet. 2006)

External Searches for NPS gene

Genome Databases showing NPS gene

Other Databases showing NPS gene

Specialized Databases showing NPS gene

Products
for NPS gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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