Aliases for NPS Gene
External Ids for NPS Gene
- HGNC: 33940
- Entrez Gene: 594857
- Ensembl: ENSG00000214285
- OMIM: 609513
- UniProtKB: P0C0P6
Previous GeneCards Identifiers for NPS Gene
- GC10U900621
- GC10P129237
- GC10P129347
- GC10P122920
Summaries for NPS Gene
GeneCards Summary for NPS Gene
NPS (Neuropeptide S) is a Protein Coding gene. Diseases associated with NPS include Spinocerebellar Ataxia 23 and Anxiety. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes.
UniProtKB/Swiss-Prot for NPS Gene
-
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPS Gene
Genomics for NPS Gene
GeneHancer (GH) Regulatory Elements for NPS Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10I127549 | Promoter | 0.5 | EPDnew | 550.8 | -0.1 | -61 | 0.1 | NPS GC10M127350 | ||
GH10I127486 | Enhancer | 0.6 | ENCODE | 10.7 | -63.9 | -63917 | 0.2 | MAX SIN3A MIER2 REST ZIC2 HIC1 CREB1 FOS | NPS GC10M127350 | |
GH10I127485 | Enhancer | 0.5 | ENCODE | 12.1 | -63.7 | -63717 | 0.2 | HIC1 MAX SIN3A MIER2 REST ZIC2 | NPS GC10M127350 | |
GH10I126645 | Enhancer | 0.4 | dbSUPER | 9.1 | -899.8 | -899778 | 7.3 | CEBPG ZIC2 | C10orf90 NPS LOC105378548 | |
GH10I127944 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 1.6 | +396.6 | 396557 | 2.6 | PKNOX1 NFIB INSM2 BRCA1 RFX5 ZNF366 SCRT2 FOS EGR2 SMARCC1 | ENSG00000232259 PTPRE ENSG00000227076 NPS GC10M127969 |
Regulatory Element Products
Genomic Locations for NPS Gene
- chr10:127,549,349-127,552,671
- (GRCh38/hg38)
- Size:
- 3,323 bases
- Orientation:
- Plus strand
- chr10:129,347,613-129,350,935
- (GRCh37/hg19)
Genomic View for NPS Gene
- Cytogenetic band:
-
- 10q26.2 by Ensembl
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC


RefSeq DNA sequence for NPS Gene
Proteins for NPS Gene
-
Protein details for NPS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0P6-NPS_HUMAN
- Recommended name:
- Neuropeptide S
- Protein Accession:
- P0C0P6
Protein attributes for NPS Gene
- Size:
- 89 amino acids
- Molecular mass:
- 10103 Da
- Quaternary structure:
- No Data Available
Protein Expression for NPS Gene
Post-translational modifications for NPS Gene
Other Protein References for NPS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Abcam antibodies for NPS
-
Cloud-Clone Corp. Antibodies for NPS
- Invitrogen Antibodies for NPS
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Protein Products
- R&D Systems Peptides for NPS (Neuropeptide S/NPS)
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-
Cloud-Clone Corp. Proteins for NPS
- antibodies-online: Search results for 6 available NPS Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for NPS
Assay Products
-
Cloud-Clone Corp. Assay Kits for NPS
- antibodies-online: Search results for 26 available NPS Elisa Kits ranked by validation data
- Compare Top NPS Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for NPS Gene
Domains & Families for NPS Gene
Gene Families for NPS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for NPS Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NPS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NPS Gene
Function for NPS Gene
Molecular function for NPS Gene
- UniProtKB/Swiss-Prot Function:
- Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Phenotypes From GWAS Catalog for NPS Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
- Search ViGene Biosciences for NPS
CRISPR Products
-
OriGene CRISPR knockouts for NPS
- genomics-online: gRNA clones - Search results for 43 available NPS gene related products
- Overview of 43 available NPS gene related products
- Applied Biological Materials CRISPR for NPS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPS
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miRNA Products
- Search ViGene Biosciences for NPS
Inhibitory RNA Products
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- Overview of 43 available NPS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NPS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NPS
-
ViGene Biosciences adenoviral particle packaged cDNA for NPS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPS Gene
Localization for NPS Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPS Gene
Pathways & Interactions for NPS Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | G alpha (s) signalling events | ||
5 | Circadian rythm related genes |
Pathways by source for NPS Gene
1 BioSystems pathway for NPS Gene
Interacting Proteins for NPS Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
GO:0007218 | neuropeptide signaling pathway | IEA | -- |
GO:0008542 | visual learning | IEA | -- |
GO:0010841 | positive regulation of circadian sleep/wake cycle, wakefulness | IEA | -- |
GO:0032230 | positive regulation of synaptic transmission, GABAergic | IEA | -- |
No data available for SIGNOR curated interactions for NPS Gene
Transcripts for NPS Gene
mRNA/cDNA for NPS Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NPS
- genomics-online: gRNA clones - Search results for 43 available NPS gene related products
- Overview of 43 available NPS gene related products
- Applied Biological Materials CRISPR for NPS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPS
- GenScript: Design CRISPR guide RNA sequences for NPS
miRNA Products
- Search ViGene Biosciences for NPS
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NPS
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- genomics-online: shRNA clones - Search results for 43 available NPS gene related products
- Overview of 43 available NPS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NPS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NPS Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPS Gene
NURSA nuclear receptor signaling pathways regulating expression of NPS Gene:
NPSSOURCE GeneReport for Unigene cluster for NPS Gene:
Hs.643423Evidence on tissue expression from TISSUES for NPS Gene
- Nervous system(4.1)
- Adrenal gland(2.8)
- Intestine(2.8)
- Skin(2.8)
- Blood(2.7)
- Muscle(2.7)
- Pancreas(2.5)
- Lung(2.4)
- Heart(2.3)
- Thyroid gland(2.2)
- Bone marrow(2)
- Lymph node(2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for NPS
-
OriGene qPCR primer pairs for NPS
- genomics-online: primer clones - Search results for 43 available NPS gene related products
- Overview of 43 available NPS gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPS Gene
Orthologs for NPS Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NPS 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nps 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nps 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | NPS 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | NPS 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | NPS 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nps 33 |
|
- Species where no ortholog for NPS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NPS Gene
No data available for Paralogs for NPS Gene
Variants for NPS Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000011465 | -- | 127,549,805(+) | A/G | intron_variant | |
rs1000570816 | -- | 127,551,621(+) | T/C | intron_variant | |
rs1001410866 | -- | 127,550,734(+) | G/A | intron_variant | |
rs1001555809 | -- | 127,552,216(+) | A/T | intron_variant | |
rs1001626522 | -- | 127,552,027(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1048716 | CNV | loss | 25217958 |
nsv7607 | CNV | deletion | 18451855 |
Additional Variant Information for NPS Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPS Gene
Disorders for NPS Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 23 |
|
|
anxiety |
|
|
retinitis pigmentosa 68 |
|
|
reflex sympathetic dystrophy |
|
|
diverticulitis of colon |
|
|
Additional Disease Information for NPS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NPS Gene
Publications for NPS Gene
- Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu YL … Civelli O (Neuron 2004) 2 3 4 58
- Assessment of the neuropeptide S system in anxiety disorders. (PMID: 20705147) Donner J … Hovatta I (Biological psychiatry 2010) 3 44 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
- Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V … Salvadori S (Journal of medicinal chemistry 2008) 2 3 58
- Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PMID: 16790440) Bernier V … Therien AG (The Journal of biological chemistry 2006) 3 4 58
Products for NPS Gene
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- Invitrogen Antibodies for NPS
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- VectorBuilder custom plasmid, inducible vectors for NPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 94 available NPS Antibodies ranked by validation data
- Compare Top NPS Antibodies
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- Quality Products:
- antibodies-online: Search results for 6 available NPS Proteins ranked by validation data
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- Search GeneTex for Antibodies for NPS
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- Overview of 43 available NPS gene related products
Sources for NPS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew