NPS Gene
protein-coding GIFtS: 41
GCID: GC10P129347
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Neuropeptide S
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Aliases
for NPS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Neuropeptide S1 2 | | Prepro-Neuropeptide S1 2 |
Export aliases for NPS gene to outside databasesPrevious GC identifers: GC10U900621 GC10P129237 GC10P122920 |
Summaries
for NPS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for NPS Gene: 
NPS (neuropeptide S) is a protein-coding gene. Diseases associated with NPS include gastrointestinal system disease, and wolfram syndrome, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding.
UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with
nanomolar affinity to increase intracellular calcium concentrations (By similarity)
Gene Wiki entry for NPS (Neuropeptide S) Gene
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Genomic Views
for NPS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.2 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPS gene promoter:
TBP C/EBPbeta HOXA3 CUTL1 FOXL1 Pax-3 S8 FOXO1a Cart-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2NPS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P129347: view genomic region
(about GC identifiers)
Start:
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129,347,613 bp from pter |
End:
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129,350,935 bp from pter |
Size:
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3,323 bases |
Orientation:
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plus strand |
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Proteins
for NPS gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6 (See
protein sequence)Recommended Name: Neuropeptide S precursor Size: 89 amino acids; 10103 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for NPS: NX_P0C0P6
Explore proteomics data for NPS at MOPED
NPS Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_001025184.1
ENSEMBL proteins: ENSP00000381105 Reactome Protein details: P0C0P6
Human Recombinant Protein Products for NPS:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
NPS for ontologies About GeneDecksing
NPS Antibody Products:
Assay Products for NPS: |
Protein
Domains /
Families
for NPS gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
ENDOLIG: Endogenous ligands
ProtoNet protein and cluster: P0C0P6 |
Function
for NPS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NPS_HUMAN, P0C0P6Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with
nanomolar affinity to increase intracellular calcium concentrations (By similarity)Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for NPS | |  | Search LifeMap BioReagents cell lines for NPS | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPS |
Pathways & Interactions
for NPS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
SuperPaths for NPS About See pathways by source
| SuperPath | Contained pathways About |
|---|
| 1 | Signaling by GPCR | | | 2 | Class A/1 (Rhodopsin-like receptors) | | | 3 | G alpha (q) signalling events | | | 4 | Prostacyclin signalling through prostacyclin receptor | |
Pathways by source See SuperPaths
Show all pathways
5/9 
Reactome Pathways for NPS (see all 9)
NPS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/183 Interacting proteins for NPS (ENSP000003811054) via UniProtKB, MINT, STRING, and/or I2D (see all 183)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
IEA | -- | | GO:0008542 | visual learning |
IEA | -- | | GO:0032230 | positive regulation of synaptic transmission, GABAergic |
IEA | -- | | GO:0045760 | positive regulation of action potential |
IEA | -- | | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
IEA | -- |
NPS for ontologies About GeneDecksing
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Drugs & Compounds
for NPS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPS
Search CenterWatch for drugs/clinical trials and news about NPS
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Transcripts
for NPS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for NPS gene: NM_001030013.1 Unigene Cluster for NPS: Neuropeptide S Hs.643423 Unigene Representative Sequence: NM_0010300131 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000398023(uc001ljx.1)
Primer
Products: |  | OriGene qPCR primer pairs and template standards for NPS
OriGene qSTAR qPCR primer pairs in human, mouse for NPS
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPS |
GeneLoc Exon Structure
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Expression
for NPS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPS expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTAAGTGTG
About this image
See NPS Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.643423
SABiosciences Custom PCR Arrays for NPS
Primer
Products: | | OriGene qPCR primer pairs and template standards for NPS
OriGene qSTAR qPCR primer pairs in human, mouse for NPS
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPS |
Orthologs
for NPS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NPS gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for NPS (if available)
TreeFam Gene Tree for NPS (if available) |
Paralogs
for NPS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NPS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPS (129347613 - 129350935 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for NPS: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPS |
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Disorders
/ Diseases
for NPS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OMIM gene information: 609513
OMIM disorders: --
14  diseases for NPS: About MalaCardsgastrointestinal system disease wolfram syndrome pthirus pubis infestation sleep apnea
encephalomyopathy mitochondrial encephalomyopathy leber hereditary optic neuropathy optic atrophy
anorexia nervosa skin disease rhinitis neuropathy
dementia asthma
15 diseases from the University of Copenhagen DISEASES database for NPS:Migraine Asthma Pain agnosia Complex regional pain syndrome
Rhinitis Sleep disorder Dermatitis Alzheimer's disease
Schizophrenia Vascular disease Arthritis Psoriasis
Diabetes mellitus Kidney failure Fibromyalgia
NPS for disorders About GeneDecksing
Genetic Association Database (GAD): NPS
Human Genome Epidemiology (HuGE) Navigator: NPS (18 documents)
Export disorders for NPS gene to outside databases
|
Publications
for NPS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPS gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with NPS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PubMed id 15312648)1, 2, 3 Xu Y.L....Civelli O. (2004)
- Assessment of the neuropeptide S system in anxiety di sorders. (PubMed id 20705147)1, 4 Donner J....Hovatta I. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
- Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PubMed id 18181564)1, 3 Camarda V....Salvadori S. (2008)
- Neuropeptide S stimulates human monocyte chemotaxis vi a NPS receptor activation. (PubMed id 23142110)1 Filaferro M....Vitale G. (2013)
- Neurobiology, pharmacology, and medicinal chemistry o f neuropeptide S and its receptor. (PubMed id 19824051)1 Guerrini R....Calo' G. (2010)
- Non-synonymous polymorphism in the neuropeptide S pre cursor gene and sleep apnea. (PubMed id 20405330)1 SA!nchez-de-la-Torre M....BarbAc F. (2010)
- Genome-wide association identifies the ABO blood grou p as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)4 Paterson A.D....Bull S.B. (2009)
- Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. (PubMed id 18376418)1 Rizzi A....Calo G. (2008)
- Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)1 Vendelin J....Kere J. (2006)
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External Searches for NPS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NPS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing NPS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPS | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NPS gene:
Search GeneIP for patents involving NPS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPS |
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 |  |  |  | |
| | | | Search Tocris compounds for NPS |
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 | | | Proteins for NPS | | | Antibodies for NPS | | | ELISAs for NPS | | | CLIAs for NPS |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPS |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NPS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPS |
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