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NPS Gene

protein-coding GIFtS: 42
GCID: GC10P129347

Neuropeptide S

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Neuropeptide S¹ ²
Prepro-Neuropeptide S¹ ²

External Ids:	HGNC: 33940¹	Entrez Gene: 594857²	Ensembl: ENSG00000214285⁷	OMIM: 609513⁵	UniProtKB: P0C0P6³

Export aliases for NPS gene to outside databases

Previous GC identifers: GC10U900621 GC10P129237 GC10P122920

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPS Gene:

NPS (neuropeptide S) is a protein-coding gene.

UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6

Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with

nanomolar affinity to increase intracellular calcium concentrations (By similarity)

Gene Wiki entry for NPS (Neuropeptide S) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000010.10 NC_018921.2 NT_030059.14

Regulatory elements:

Regulatory transcription factor binding sites in the NPS gene promoter:
TBP C/EBPbeta HOXA3 CUTL1 FOXL1 Pax-3 S8 FOXO1a Cart-1 FOXO1
Other transcription factors

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Search Chromatin IP Primers for NPS

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2

NPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPS gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P129347: view genomic region (about GC identifiers)

Start:	129,347,613 bp from pter	End:	129,350,935 bp from pter
Size:	3,323 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6 (See protein sequence)

Recommended Name: Neuropeptide S precursor

Size: 89 amino acids; 10103 Da

Explore the universe of human proteins at neXtProt for NPS: NX_P0C0P6

Explore proteomics data for NPS at MOPED

See NPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001025184.1

ENSEMBL proteins:

ENSP00000381105

Reactome Protein details: P0C0P6

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

1 InterPro protein domain:

IPR028138 Neuropeptide_S

Graphical View of Domain Structure for InterPro Entry P0C0P6

ProtoNet protein and cluster: P0C0P6

Find genes that share domains with NPS About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NPS_HUMAN, P0C0P6

Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with

nanomolar affinity to increase intracellular calcium concentrations (By similarity)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NPS_HUMAN, P0C0P6: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
nucleus	3
cytoskeleton	2
endoplasmic reticulum	2
golgi apparatus	2
mitochondrion	2
plasma membrane	2
cytosol	1
endosome	1

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

Find genes that share ontologies with NPS About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NPS About

See pathways by source

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by

SuperPath

Contained pathways About

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71

Gastrin-CREB signalling pathway via PKC and MAPK

G alpha (q) signalling events

0.90

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

G alpha (s) signalling events

G alpha (s) signalling events

Find genes that share SuperPaths with NPS About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

3 Reactome Pathways for NPS

	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (s) signalling events

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Interactions:

GeneGlobe Interaction Network for NPS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NPS (ENSP00000381105⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 183)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADM	ENSP00000278175⁴	STRING: ENSP00000278175
ADRB1	ENSP00000358301⁴	STRING: ENSP00000358301
APP	ENSP00000284981⁴	STRING: ENSP00000284981
AVPR2	ENSP00000338072⁴	STRING: ENSP00000338072
CASR	ENSP00000296154⁴	STRING: ENSP00000296154

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007218	neuropeptide signaling pathway	IEA	--
GO:0008542	visual learning	IEA	--
GO:0032230	positive regulation of synaptic transmission, GABAergic	IEA	--
GO:0045760	positive regulation of action potential	IEA	--
GO:0051968	positive regulation of synaptic transmission, glutamatergic	IEA	--

Find genes that share ontologies with NPS About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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REFSEQ mRNAs for NPS gene:

NM_001030013.1

Unigene Cluster for NPS:

Neuropeptide S

Hs.643423

Unigene Representative Sequence: NM_001030013

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000398023(uc001ljx.1)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTAAGTGTG

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NPS Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NPS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.643423

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NPS gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nps^{1 , 5}	neuropeptide S^{1, 5}	81.44(n)¹ 73.86(a)¹		7 (81.27 cM)⁵ 100043254¹ NM_001163611.1¹ NP_001157083.1¹ 135268619⁵
lizard (Anolis carolinensis)	Reptilia	NPS⁶	neuropeptide S	67(a)	1 ↔ 1	3(53569447-53569635)
tropical clawed frog (Xenopus tropicalis)	Amphibia	nps¹	neuropeptide S	60.85(n) 61.63(a)		101735179 XM_004912718.1 XP_004912775.1

ENSEMBL Gene Tree for NPS (if available)
TreeFam Gene Tree for NPS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59121543^1,2	C	--	122919006(+)	`CCTGC-/ATGC/ATGCGT/ATGCGTGT/AT GCGTGTGTGT/ATGCGTGTGTGTGTgtgtg`	3	--	us2k¹ cds¹		0	--	--	--	--
rs11597503^1,2	C,F,H	--	129345622(+)	`atggcG/Acatgg`	1	--	us2k¹		14		NS EA NA WA CSA	627
rs191800975^1,2		--	129345631(+)	`GGTCCC/TAGCTA`	1	--	us2k¹		0	--	--	--	--
rs150040921^1,2		--	129345685(+)	`AGGCTA/GCAGTG`	1	--	us2k¹		0	--	--	--	--
rs184012040^1,2		--	129345784(+)	`CTCCTA/GCCAAT`	1	--	us2k¹		0	--	--	--	--
rs11018189^1,2	C,F,H	--	129345788(+)	`TGCCAA/GTTCTA`	1	--	us2k¹		22		NS EA NA WA	2766
rs145394520^1,2		--	129345871(+)	`TTTCCA/GCTTAA`	1	--	us2k¹		0	--	--	--	--
rs190312845^1,2		--	129345906(+)	`CTACAG/TGCAAA`	1	--	us2k¹		0	--	--	--	--
rs201342712^1,2		--	129346016(+)	`GTTCC-/TGCA TGCGT`	1	--	us2k¹		0	--	--	--	--
rs7898056^1,2	C	--	129346020(+)	`CCtgcA/C/Gtgtgt`	1	--	us2k¹		2		CSA	3

HapMap Linkage Disequilibrium report for NPS (129347613 - 129350935 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for NPS: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7607	CNV	Loss	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609513 OMIM disorders: --

15 inferred disease relationships from the University of Copenhagen DISEASES database for NPS:

Migraine Asthma Pain agnosia Complex regional pain syndrome

Rhinitis Sleep disorder Dermatitis Alzheimer's disease

Schizophrenia Vascular disease Arthritis Psoriasis

Diabetes mellitus Kidney failure Fibromyalgia

Find genes that share disorders with NPS About GenesLikeMe

Genetic Association Database (GAD): NPS
Human Genome Epidemiology (HuGE) Navigator: NPS (18 documents)

Export disorders for NPS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPS gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with NPS)

Utopia: connect your pdf to the dynamic
world of online information

Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PubMed id 15312648)^{1, 2, 3} Xu Y.-L....Civelli O. (Neuron 2004)
Assessment of the neuropeptide S system in anxiety disorders. (PubMed id 20705147)^{1, 4} Donner J....Hovatta I. (Biol. Psychiatry 2010)
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PubMed id 18181564)^{1, 3} Camarda V....Salvadori S. (J. Med. Chem. 2008)
Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation. (PubMed id 23142110)¹ Filaferro M....Vitale G. (Peptides 2013)
Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. (PubMed id 20405330)¹ SA!nchez-de-la-Torre M....BarbAc F. (amp 2011)
Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor. (PubMed id 19824051)¹ Guerrini R....Calo' G. (Med Res Rev 2010)
Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)⁴ Paterson A.D....Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009)
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. (PubMed id 18376418)¹ Rizzi A....Calo G. (Br. J. Pharmacol. 2008)
Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)¹ Vendelin J....Kere J. (Hum. Mol. Genet. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 594857	HGNC: 33940	Ensembl:ENSG00000214285	euGenes: HUgn594857	ECgene: NPS
H-InvDB: NPS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NPS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NPS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NPS gene:
Search GeneIP for patents involving NPS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	Custom PCR Arrays for NPS		Search Chromatin IP Primers for NPS
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat NPS		GeneGlobe Interaction Network for NPS
	Regulatory tfbs in NPS promoter

	GenScript Custom Purified and Recombinant Proteins Services for NPS		GenScript cDNA clones with any tag delivered in your preferred vector for NPS
	GenScript Custom Assay Services for NPS		GenScript Custom overexpressing Cell Line Services for NPS
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NPS gene at Home site.

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Neuropeptide S

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NPS Gene

Neuropeptide S

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NPS Human Recombinant Protein Products:

NPS Antibody Products:

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