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NPS Gene(Protein Coding)

Neuropeptide S

GCID:
GC10P127549
GIFtS:
40
Genes Participants
UDN Logo

Aliases for NPS Gene

Aliases for NPS Gene

  • Neuropeptide S 2 3 5
  • Prepro-Neuropeptide S 2

External Ids for NPS Gene

Previous GeneCards Identifiers for NPS Gene

  • GC10U900621
  • GC10P129237
  • GC10P129347
  • GC10P122920

Summaries for NPS Gene

GeneCards Summary for NPS Gene

NPS (Neuropeptide S) is a Protein Coding gene. Diseases associated with NPS include Spinocerebellar Ataxia 23 and Anxiety. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes.

UniProtKB/Swiss-Prot for NPS Gene

  • Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Gene Wiki entry for NPS Gene

Additional gene information for NPS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPS Gene

Genomics for NPS Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NPS Gene

Promoters and enhancers for NPS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I127549 Promoter 0.5 EPDnew 550.8 -0.1 -61 0.1 NPS GC10M127350
GH10I127486 Enhancer 0.6 ENCODE 10.7 -63.9 -63917 0.2 MAX SIN3A MIER2 REST ZIC2 HIC1 CREB1 FOS NPS GC10M127350
GH10I127485 Enhancer 0.5 ENCODE 12.1 -63.7 -63717 0.2 HIC1 MAX SIN3A MIER2 REST ZIC2 NPS GC10M127350
GH10I126645 Enhancer 0.4 dbSUPER 9.1 -899.8 -899778 7.3 CEBPG ZIC2 C10orf90 NPS LOC105378548
GH10I127944 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +396.6 396557 2.6 PKNOX1 NFIB INSM2 BRCA1 RFX5 ZNF366 SCRT2 FOS EGR2 SMARCC1 ENSG00000232259 PTPRE ENSG00000227076 NPS GC10M127969
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPS gene promoter:

Genomic Locations for NPS Gene

Genomic Locations for NPS Gene
chr10:127,549,349-127,552,671
(GRCh38/hg38)
Size:
3,323 bases
Orientation:
Plus strand
chr10:129,347,613-129,350,935
(GRCh37/hg19)

Genomic View for NPS Gene

Genes around NPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NPS Gene

Proteins for NPS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0P6-NPS_HUMAN
    Recommended name:
    Neuropeptide S
    Protein Accession:
    P0C0P6

    Protein attributes for NPS Gene

    Size:
    89 amino acids
    Molecular mass:
    10103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPS Gene

Protein Expression for NPS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NPS Gene

No Post-translational modifications

Other Protein References for NPS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPS Gene

Domains & Families for NPS Gene

Gene Families for NPS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NPS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NPS: view

No data available for UniProtKB/Swiss-Prot for NPS Gene

Function for NPS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NPS Gene

UniProtKB/Swiss-Prot Function:
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Phenotypes From GWAS Catalog for NPS Gene

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPS Gene

Localization for NPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPS gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPS Gene

Pathways & Interactions for NPS Gene

genes like me logo Genes that share pathways with NPS: view

Interacting Proteins for NPS Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381105%0d%0a9606.ENSP00000253796%0d%0a9606.ENSP00000279230%0d%0a9606.ENSP00000340943%0d%0a9606.ENSP00000296677%0d%0a9606.ENSP00000342952%0d%0a
Selected Interacting proteins: ENSP00000381105 for NPS Gene via STRING

Gene Ontology (GO) - Biological Process for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008542 visual learning IEA --
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IEA --
GO:0032230 positive regulation of synaptic transmission, GABAergic IEA --
genes like me logo Genes that share ontologies with NPS: view

No data available for SIGNOR curated interactions for NPS Gene

Drugs & Compounds for NPS Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NPS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NPS Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPS Gene

No ASD Table

Relevant External Links for NPS Gene

GeneLoc Exon Structure for
NPS
ECgene alternative splicing isoforms for
NPS

Expression for NPS Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPS Gene

mRNA expression in normal human tissues for NPS Gene
mRNA expression by GTEx for NPS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPS Gene



NURSA nuclear receptor signaling pathways regulating expression of NPS Gene:

NPS

SOURCE GeneReport for Unigene cluster for NPS Gene:

Hs.643423

Evidence on tissue expression from TISSUES for NPS Gene

  • Nervous system(4.1)
  • Adrenal gland(2.8)
  • Intestine(2.8)
  • Skin(2.8)
  • Blood(2.7)
  • Muscle(2.7)
  • Pancreas(2.5)
  • Lung(2.4)
  • Heart(2.3)
  • Thyroid gland(2.2)
  • Bone marrow(2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with NPS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPS Gene

Orthologs for NPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NPS 33 34
  • 98.13 (n)
rat
(Rattus norvegicus)
 Mammalia Nps 33
  • 82.58 (n)
mouse
(Mus musculus)
 Mammalia Nps 33 16 34
  • 81.44 (n)
dog
(Canis familiaris)
 Mammalia NPS 34
  • 78 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia NPS 34
  • 56 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NPS 34
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nps 33
  • 60.85 (n)
Species where no ortholog for NPS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPS Gene

ENSEMBL:
Gene Tree for NPS (if available)
TreeFam:
Gene Tree for NPS (if available)

Paralogs for NPS Gene

No data available for Paralogs for NPS Gene

Variants for NPS Gene

Sequence variations from dbSNP and Humsavar for NPS Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000011465 -- 127,549,805(+) A/G intron_variant
rs1000570816 -- 127,551,621(+) T/C intron_variant
rs1001410866 -- 127,550,734(+) G/A intron_variant
rs1001555809 -- 127,552,216(+) A/T intron_variant
rs1001626522 -- 127,552,027(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPS Gene

Variant ID Type Subtype PubMed ID
nsv1048716 CNV loss 25217958
nsv7607 CNV deletion 18451855

Variation tolerance for NPS Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPS Gene

Human Gene Mutation Database (HGMD)
NPS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPS Gene

Disorders for NPS Gene

MalaCards: The human disease database

(23) MalaCards diseases for NPS Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 23
  • sca23
anxiety
  • anxiety disorder
retinitis pigmentosa 68
  • rp68
reflex sympathetic dystrophy
  • complex regional pain syndrome
diverticulitis of colon
  • colonic diverticular disease
- elite association - COSMIC cancer census association via MalaCards
Search NPS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPS Gene

Publications for NPS Gene

  1. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu YL … Civelli O (Neuron 2004) 2 3 4 58
  2. Assessment of the neuropeptide S system in anxiety disorders. (PMID: 20705147) Donner J … Hovatta I (Biological psychiatry 2010) 3 44 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  4. Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V … Salvadori S (Journal of medicinal chemistry 2008) 2 3 58
  5. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PMID: 16790440) Bernier V … Therien AG (The Journal of biological chemistry 2006) 3 4 58

Products for NPS Gene

Sources for NPS Gene

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