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NPS Gene

protein-coding GIFtS: 32

GC10P129237

neuropeptide S
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Descriptions
neuropeptide S ^²

External Ids
HGNC: 33940¹
Entrez Gene: 594857²
UniProtKB: P0C0P6³
Ensembl: ENSG00000214285⁷

Search outside databases for aliases for NPS gene

Previous GC identifer: GC10U900621

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6

Function: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.2 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.2

NPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P129237: (about GC identifiers)

Start:	129,237,603 bp from pter
End:	129,240,925 bp from pter
Size:	3,323 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008818.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6 (See protein sequence)

Recommended Name: Neuropeptide S precursor

Size: 89 amino acids; 10103 Da

Subcellular location: Secreted (Potential)

REFSEQ proteins: NP_001025184.1

ENSEMBL proteins:

ENSP00000381105

Human Recombinant Proteins

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Neuropeptide S)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: NPS

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for NPS:

	Browse Antibodies Central at Invitrogen
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	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Neuropeptide S), each with their Abpromise^SM
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	Search Novus for antibodies for NPS

Assays for NPS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P0C0P6

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001030013

Applied Biosystems Silencer® siRNAs for NPS

Sigma-Aldrich siRNA for NPS

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001030013
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001030013
untagged cDNA clone in CMV expression vector: NM_001030013

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001030013

UniProtKB/Swiss-Prot: NPS_HUMAN, P0C0P6

Function: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for NPS

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007218	neuropeptide signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NPS

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001030013

Sigma-Aldrich siRNA for NPS

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001030013

REFSEQ mRNAs for NPS gene:

NM_001030013.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001030013

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001030013
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001030013
                                 untagged cDNA clone in CMV expression vector: NM_001030013

highest scoring ESTs for NPS:

NM_001030013

Unigene Cluster for NPS:

Neuropeptide S

Hs.643423

Unigene Representative Sequence: NM_001030013

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000398023

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NPS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NPS

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: ACTAAGTGTG

SOURCE GeneReport for Unigene cluster: Hs.643423

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NPS gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	NPS¹	--	neuropeptide S	98.13(n) 95.51(a)	739817 XM_001141427.1 XP_001141427.1
cow (Bos taurus)	NPS¹	--	neuropeptide S	86.89(n) 76.4(a)	613540 XM_873158.2 XP_878251.2
mouse (Mus musculus)	Nps⁵	7	neuropeptide S	--	BF469178

About this table Species with no ortholog for NPS

ENSEMBL Gene Tree for NPS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/67 NCBI SNPs in NPS are shown (see all 67 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 98)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7914168^1,2	A,C,F,H	129237561(+)	`TCTGAG/CAGTAA`	1	--	ng5¹		4		EU EA WA	416
	rs10830125^1,2	A,C,F,H	129241165(+)	`CTTTGC/GTTTTA`	1	--	ng3¹		4		EU EA WA	414
	rs7910780^1,2	A,C,F,H	129236295(+)	`CAGTTC/TCCCAA`	1	--	ng5¹		12		EU EA WA	1254
	rs1931706^1,2	A,C,F,H	129236189(+)	`TAATCT/CTGTGA`	1	--	ng5¹		8		EU EA WA	832
	rs11018189^1,2	C,F,H	129235778(+)	`TGCCAA/GTTCTA`	1	--	ng5¹		8		EU EA WA	838
	rs7071923^1,2	C,F,H	129241236(+)	`TGCCTA/GTAATA`	1	--	ng3¹		4		EU EA WA	418
--	rs10765131^1,2	A,C,H	129237182(+)	`TAGATG/ATTCTT`	1	--	ng5¹		1		WA	112
--	rs11597503^1,2	C,F,H	129235612(+)	`atggcG/Acatgg`	1	--	ng5¹		3		EU EA	252
	rs990310^1,2	C,F,H	129237775(+)	`TCTGTC/TGCTGT`	1	S/L	mis¹		1		EU	120
	rs7921566^1,2	A,C	129237472(+)	`CACAGA/CCAGAA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NPS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609513

Human Genome Epidemiology Navigator: NPS (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10 PubMed articles for NPS gene:

Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PubMed id 18181564)^{2, 3} Camarda V....Salvadori S. (2008)
Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PubMed id 15312648)^{2, 3} Xu Y.L....Civelli O. (2004)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. (PubMed id 18376418)³ Rizzi A....Calo G. (2008)
Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. (PubMed id 16574794)³ Smith K.L....Bloom S.R. (2006)
Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. (PubMed id 16790440)³ Bernier V....Therien A.G. (2006)
Downstream target genes of the neuropeptide S-NPSR1 pathway. (PubMed id 16926187)³ Vendelin J....Kere J. (2006)
Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation. (PubMed id 16720571)³ Roth A.L....Guerrini R. (2006)
Neuropeptide S as a novel arousal promoting peptide transmitter. (PubMed id 16279934)³ Reinscheid R.K. and Xu Y.L. (2005)
Neuropeptide S and its receptor: a newly deorphanized G protein-coupled receptor system. (PubMed id 16282594)³ Reinscheid R.K. and Xu Y.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 594857	HGNC: 33940	Ensembl:ENSG00000214285	euGenes: HUgn594857	ECgene: NPS
H-InvDB: NPS

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NPS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NPS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NPS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NPS		Browse antibodies at Sigma-Aldrich
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	Recombinant Proteins (Neuropeptide S)
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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for NPS

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NPS Gene

protein-coding GIFtS: 32

Aliases &
Descriptions
for NPS

Summaries
for NPS

Genomic Location
for NPS

Proteins
for NPS

Protein Domains/
Families
for NPS

Gene Function
for NPS

Pathways & Interactions
for NPS

Drugs & Compounds
for NPS

Transcripts
for NPS

Expression
for NPS

Orthologs
for NPS

Paralogs
for NPS

SNPs/Variants
for NPS

Disorders & Mutations
for NPS

Medical News
for NPS

Publications
for NPS

Search for NPS

Genome Databases showing NPS

Other Databases showing NPS

Specialized Databases showing NPS

Licensable Technologies
for NPS

Services
for NPS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NPS Gene

protein-coding GIFtS: 32

Aliases & Descriptionsfor NPS

Summariesfor NPS

Genomic Locationfor NPS

Proteinsfor NPS

Protein Domains/Familiesfor NPS

Gene Functionfor NPS

Pathways & Interactionsfor NPS

Drugs & Compoundsfor NPS

Transcriptsfor NPS

Expression for NPS

Orthologsfor NPS

Paralogsfor NPS

SNPs/Variantsfor NPS

Disorders & Mutationsfor NPS

Medical Newsfor NPS

Publicationsfor NPS

Search for NPS

Genome Databases showing NPS

Other Databases showing NPS

Specialized Databases showing NPS

Licensable Technologiesfor NPS

Servicesfor NPS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NPS

Summaries
for NPS

Genomic Location
for NPS

Proteins
for NPS

Protein Domains/
Families
for NPS

Gene Function
for NPS

Pathways & Interactions
for NPS

Drugs & Compounds
for NPS

Transcripts
for NPS

Expression
for NPS

Orthologs
for NPS

Paralogs
for NPS

SNPs/Variants
for NPS

Disorders & Mutations
for NPS

Medical News
for NPS

Publications
for NPS

Licensable Technologies
for NPS

Services
for NPS