Aliases for NPS Gene
External Ids for NPS Gene
- HGNC: 33940
- Entrez Gene: 594857
- Ensembl: ENSG00000214285
- OMIM: 609513
- UniProtKB: P0C0P6
Previous GeneCards Identifiers for NPS Gene
- GC10U900621
- GC10P129237
- GC10P129347
- GC10P122920
Summaries for NPS Gene
GeneCards Summary for NPS Gene
NPS (Neuropeptide S) is a Protein Coding gene. Diseases associated with NPS include Epicondylitis and Autonomic Nervous System Disease. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling.
UniProtKB/Swiss-Prot for NPS Gene
-
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPS Gene
Genomics for NPS Gene
Regulatory Elements for NPS Gene
Enhancers for NPS Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around NPS on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NPS Gene
- Chromosome:
- 10
- Start:
- 127,549,349 bp from pter
- End:
- 127,552,671 bp from pter
- Size:
- 3,323 bases
- Orientation:
- Plus strand
Genomic View for NPS Gene
Genes around NPS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.2 by Ensembl
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC
NPS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NPS Gene
Proteins for NPS Gene
-
Protein details for NPS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0P6-NPS_HUMAN
- Recommended name:
- Neuropeptide S
- Protein Accession:
- P0C0P6
Protein attributes for NPS Gene
- Size:
- 89 amino acids
- Molecular mass:
- 10103 Da
- Quaternary structure:
- No Data Available
Protein Expression for NPS Gene
Post-translational modifications for NPS Gene
No Post-translational modifications
Other Protein References for NPS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Abcam antibodies for Neuropeptide S
-
Cloud-Clone Corp. Antibodies for NPS
- Invitrogen Antibodies for NPS
- antibodies-online Antibodies for NPS: See all 77
- GeneTex NPS antibody for NPS
-
Santa Cruz Biotechnology (SCBT) Antibodies for NPS
Protein Products
-
OriGene Purified Proteins for NPS
- Search Origene for MassSpec and Protein Over-expression Lysates for NPS
- Origene Custom Protein Services for NPS
-
Cloud-Clone Corp. Proteins for NPS
- antibodies-online Proteins for NPS: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NPS
- Abcam proteins for Neuropeptide S
No data available for DME Specific Peptides for NPS Gene
Domains & Families for NPS Gene
Gene Families for NPS Gene
- HGNC:
Protein Domains for NPS Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NPS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NPS Gene
Function for NPS Gene
Molecular function for NPS Gene
- UniProtKB/Swiss-Prot Function:
- Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).
Animal Model Products
-
Taconic Biosciences Mouse Models for NPS
-
ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
- Search ViGene Biosciences for NPS
CRISPR Products
-
OriGene CRISPR knockouts for NPS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPS
- GenScript: Design CRISPR guide RNA sequences for NPS
miRNA Products
- Search ViGene Biosciences for NPS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NPS
- Browse OriGene Inhibitory RNA Products For NPS
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
Clone Products
- OriGene clones in human for NPS
- OriGene ORF clones in human,mouse,rat for NPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NPS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPS Gene
Localization for NPS Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| cytoskeleton | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| mitochondrion | 2 |
| plasma membrane | 2 |
| endosome | 1 |
| lysosome | 1 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for NPS Gene
Pathways & Interactions for NPS Gene
More details on SuperPathways for NPS| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Interleukin-3, 5 and GM-CSF signaling | ||
| 4 | G alpha (s) signalling events |
Pathways by source for NPS Gene
Interacting Proteins for NPS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007218 | neuropeptide signaling pathway | IEA | -- |
| GO:0010841 | positive regulation of circadian sleep/wake cycle, wakefulness | IEA | -- |
| GO:0045760 | positive regulation of action potential | IEA | -- |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | IEA | -- |
No data available for SIGNOR curated interactions for NPS Gene
Transcripts for NPS Gene
mRNA/cDNA for NPS Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NPS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPS
- GenScript: Design CRISPR guide RNA sequences for NPS
miRNA Products
- Search ViGene Biosciences for NPS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NPS
- Browse OriGene Inhibitory RNA Products For NPS
-
ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
Clone Products
- OriGene clones in human for NPS
- OriGene ORF clones in human,mouse,rat for NPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for NPS Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPS Gene
SOURCE GeneReport for Unigene cluster for NPS Gene Hs.643423
Primer Products
-
OriGene qPCR primer pairs and template standards for NPS
-
OriGene qPCR primer pairs for NPS
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NPS Gene
Orthologs for NPS Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Nps 35 |
|
||
| Nps 16 |
|
||||
| Nps 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | NPS 35 |
|
||
| NPS 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Nps 35 |
|
||
| dog (Canis familiaris) |
Mammalia | NPS 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NPS 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NPS 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nps 35 |
|
- Species with no ortholog for NPS:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for NPS Gene
No data available for Paralogs for NPS Gene
Variants for NPS Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs990310 | - | 127,549,521(+) | TCTGT(C/T)GCTGT | reference, missense | |
| rs4751440 | - | 127,552,592(+) | ATGGA(A/C/G)TTGGC | reference, missense | |
| rs1931706 | -- | 127,547,935(+) | TAATC(C/T)TGTGA | upstream-variant-2KB | |
| rs1931707 | -- | 127,548,093(+) | AGACA(C/G)AGGGC | upstream-variant-2KB | |
| rs1931708 | -- | 127,551,569(+) | TAATA(A/G)TATCT | intron-variant |
Residual Variation Intolerance Score:
77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.26;
62.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NPS Gene
- Human Gene Mutation Database (HGMD)
- NPS
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPS Gene
Disorders for NPS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epicondylitis |
|
|
| autonomic nervous system disease |
|
|
| vasomotor rhinitis |
|
|
| reflex sympathetic dystrophy |
|
|
| alcohol-induced mental disorder |
|
|
Search NPS in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NPS
No data available for UniProtKB/Swiss-Prot and Genatlas for NPS Gene
Publications for NPS Gene
- Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu Y.-L. … Civelli O. (Neuron 2004) 2 3 4 67
- Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V. … Salvadori S. (J. Med. Chem. 2008) 2 3
- Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation. (PMID: 23142110) Filaferro M. … Vitale G. (Peptides 2013) 3
- A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity. (PMID: 24386135) Deng C. … Hsueh A.J. (PLoS ONE 2013) 3
- Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. (PMID: 20405330) SA!nchez-de-la-Torre M. … BarbAc F. (Sleep Breath 2011) 3
Products for NPS Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NPS
- Search Origene for MassSpec and Protein Over-expression Lysates for NPS
- Origene Custom Protein Services for NPS
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for NPS
- Browse OriGene Inhibitory RNA Products For NPS
- OriGene qPCR primer pairs for NPS
- OriGene qPCR primer pairs and template standards for NPS
- OriGene CRISPR knockouts for NPS
- OriGene clones in human for NPS
- OriGene ORF clones in human,mouse,rat for NPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for NPS
- GenScript Custom Assay Services for NPS
- GenScript Custom overexpressing Cell Line Services for NPS
- GenScript: Design CRISPR guide RNA sequences for NPS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NPS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for Neuropeptide S
- Abcam proteins for Neuropeptide S
- Search for Assays for NPS at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for NPS
- Cloud-Clone Corp. Proteins for NPS
- Cloud-Clone Corp Assay Kits for NPS
- Taconic Biosciences Mouse Models for NPS
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for NPS: See all 77
- antibodies-online Kits for NPS: See all 15
- antibodies-online Proteins for NPS: See all 7
- Search antibodies-online for peptides
- GeneTex NPS antibody for NPS
- Search GeneTex for Proteins for NPS
- ViGene Biosciences adenoviral particle packaged cDNA for NPS gene
- ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
- ViGene Biosciences lentiviral particle packaged cDNA for NPS gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPS gene
- Search ViGene Biosciences for NPS
- Search ViGene Biosciences for NPS
- Santa Cruz Biotechnology (SCBT) Antibodies for NPS
- Search Santa Cruz Biotechnology (SCBT) for NPS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NPS
Sources for NPS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon