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Aliases for NPRL3 Gene

Aliases for NPRL3 Gene

  • Nitrogen Permease Regulator-Like 3 (S. Cerevisiae) 2 3
  • CGTHBA 3 4 6
  • Alpha-Globin Regulatory Element-Containing Gene Protein 3 4
  • Conserved Gene Telomeric To Alpha Globin Cluster 2 3
  • -14 Gene Protein 3 4
  • C16orf35 3 4
  • MARE 3 4
  • Nitrogen Permease Regulator 3-Like Protein 3
  • Chromosome 16 Open Reading Frame 35 2
  • Protein CGTHBA 4
  • HS-40 3
  • RMD11 3
  • NPR3 3

External Ids for NPRL3 Gene

Previous Symbols for NPRL3 Gene

  • C16orf35

Summaries for NPRL3 Gene

Entrez Gene Summary for NPRL3 Gene

  • The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]

GeneCards Summary for NPRL3 Gene

NPRL3 (Nitrogen Permease Regulator-Like 3 (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with NPRL3 include secondary hypertrophic osteoarthropathy and myoblastoma. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for NPRL3 Gene

  • As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPRL3 Gene

Genomics for NPRL3 Gene

Genomic Location for NPRL3 Gene

84,271 bp from pter
138,860 bp from pter
54,590 bases
Minus strand

Genomic View for NPRL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPRL3 Gene

No data available for Regulatory Elements for NPRL3 Gene

Proteins for NPRL3 Gene

  • Protein details for NPRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nitrogen permease regulator 3-like protein
    Protein Accession:
    Secondary Accessions:
    • D3DU40
    • Q1W6H0
    • Q4TT56
    • Q92469

    Protein attributes for NPRL3 Gene

    569 amino acids
    Molecular mass:
    63605 Da
    Quaternary structure:
    • Forms a heterodimer with NPRL2. Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

neXtProt entry for NPRL3 Gene

Proteomics data for NPRL3 Gene at MOPED

Post-translational modifications for NPRL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys253 and Lys546

No data available for DME Specific Peptides for NPRL3 Gene

Domains for NPRL3 Gene

Protein Domains for NPRL3 Gene



  • Belongs to the NPR3 family.:
    • Q12980
genes like me logo Genes that share domains with NPRL3: view

No data available for Gene Families for NPRL3 Gene

Function for NPRL3 Gene

Molecular function for NPRL3 Gene

UniProtKB/Swiss-Prot Function: As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Gene Ontology (GO) - Molecular Function for NPRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with NPRL3: view
genes like me logo Genes that share phenotypes with NPRL3: view

Animal Models for NPRL3 Gene

MGI Knock Outs for NPRL3:

miRNA for NPRL3 Gene

miRTarBase miRNAs that target NPRL3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPRL3 Gene

Localization for NPRL3 Gene

Subcellular locations from

Jensen Localization Image for NPRL3 Gene COMPARTMENTS Subcellular localization image for NPRL3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NPRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NPRL3: view

Pathways for NPRL3 Gene

SuperPathways for NPRL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0008150 biological_process ND --
GO:0035909 aorta morphogenesis IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048738 cardiac muscle tissue development IEA --
genes like me logo Genes that share ontologies with NPRL3: view

No data available for Pathways by source for NPRL3 Gene

Transcripts for NPRL3 Gene

Unigene Clusters for NPRL3 Gene

Nitrogen permease regulator-like 3 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPRL3 Gene

No ASD Table

Relevant External Links for NPRL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPRL3 Gene

mRNA expression in normal human tissues for NPRL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPRL3 Gene

This gene is overexpressed in Whole Blood (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPRL3 Gene

SOURCE GeneReport for Unigene cluster for NPRL3 Gene Hs.19699

mRNA Expression by UniProt/SwissProt for NPRL3 Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with NPRL3: view

Orthologs for NPRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPRL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPRL3 36
  • 99.51 (n)
  • 99.82 (a)
NPRL3 37
  • 99 (a)
(Bos Taurus)
Mammalia NPRL3 36
  • 89.93 (n)
  • 93.55 (a)
NPRL3 37
  • 93 (a)
(Canis familiaris)
Mammalia NPRL3 36
  • 90.93 (n)
  • 96.69 (a)
NPRL3 37
  • 97 (a)
(Mus musculus)
Mammalia Nprl3 36
  • 88.83 (n)
  • 96.32 (a)
Nprl3 16
Nprl3 37
  • 96 (a)
(Monodelphis domestica)
Mammalia NPRL3 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia NPRL3 37
  • 70 (a)
(Rattus norvegicus)
Mammalia Nprl3 36
  • 88.89 (n)
  • 95.77 (a)
(Gallus gallus)
Aves -- 37
  • 74 (a)
  • 86 (a)
NPRL3 36
  • 78.64 (n)
  • 87.48 (a)
(Anolis carolinensis)
Reptilia NPRL3 37
  • 85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68624 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nprl3 36
  • 72.12 (n)
  • 82.72 (a)
Str.18308 36
(Danio rerio)
Actinopterygii nprl3 36
  • 73.96 (n)
  • 78.66 (a)
nprl3 37
  • 72 (a)
wufb68d06 36
fruit fly
(Drosophila melanogaster)
Insecta CG8783 36
  • 51.08 (n)
  • 42.21 (a)
CG8783 37
  • 36 (a)
(Caenorhabditis elegans)
Secernentea nprl-3 36
  • 39.66 (n)
  • 28.92 (a)
nprl-3 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for NPRL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPRL3 Gene

Gene Tree for NPRL3 (if available)
Gene Tree for NPRL3 (if available)

Paralogs for NPRL3 Gene

Selected SIMAP similar genes for NPRL3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NPRL3: view

No data available for Paralogs for NPRL3 Gene

Variants for NPRL3 Gene

Sequence variations from dbSNP and Humsavar for NPRL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs170026 -- 119,694(-) AGGGC(C/T)GCTCT intron-variant
rs177510 -- 113,627(-) GCACT(A/G)AGTCA intron-variant
rs183350 -- 111,939(-) gacac(C/T)tgtaa intron-variant
rs183351 -- 108,439(-) ttctc(A/G)ggggt intron-variant
rs216086 -- 113,419(-) TCTTG(A/G)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPRL3 Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv518291 CNV Loss 19592680
nsv904628 CNV Loss 21882294
nsv904631 CNV Loss 21882294
esv32706 CNV Loss 17666407
nsv9317 CNV Gain 18304495
nsv904634 CNV Loss 21882294
nsv904635 CNV Gain 21882294
nsv1697 CNV Insertion 18451855
esv1304431 CNV Insertion 17803354
esv2657149 CNV Deletion 23128226
dgv2458n71 CNV Loss 21882294

Relevant External Links for NPRL3 Gene

HapMap Linkage Disequilibrium report

Disorders for NPRL3 Gene


  • Note=Inactivating mutations and truncating deletions in the genes encoding GATOR1 proteins are detected in glioblastoma and ovarian tumors and are associated with loss of heterozygosity events. Inactivation of GATOR1 proteins promotes constitutive localization of mTORC1 to the lysosomal membrane and blocks mTORC1 inactivation following amino acid withdrawal (PubMed:23723238). {ECO:0000269 PubMed:23723238}.

(3) University of Copenhagen DISEASES for NPRL3 Gene

genes like me logo Genes that share disorders with NPRL3: view

Publications for NPRL3 Gene

  1. Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element. (PMID: 8575760) Vyas P. … Higgs D. (Genomics 1995) 2 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  3. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PMID: 16728641) De Gobbi M. … Higgs D.R. (Science 2006) 3 4
  4. A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. (PMID: 19521502) Neklesa T.K. … Davis R.W. (PLoS Genet. 2009) 3 4
  5. The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73. (PMID: 19666006) Lunardi A. … Collavin L. (Biochem. Biophys. Res. Commun. 2009) 3

Products for NPRL3 Gene

Sources for NPRL3 Gene

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