Aliases for NPRL3 Gene
External Ids for NPRL3 Gene
Previous HGNC Symbols for NPRL3 Gene
Previous GeneCards Identifiers for NPRL3 Gene
The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]
GeneCards Summary for NPRL3 Gene
NPRL3 (NPR3 Like, GATOR1 Complex Subunit) is a Protein Coding gene. Diseases associated with NPRL3 include Secondary Hypertrophic Osteoarthropathy and Myoblastoma. GO annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for NPRL3 Gene
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.