Aliases for NPRL3 Gene
External Ids for NPRL3 Gene
Previous Symbols for NPRL3 Gene
The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]
GeneCards Summary for NPRL3 Gene
NPRL3 (Nitrogen Permease Regulator-Like 3 (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with NPRL3 include secondary hypertrophic osteoarthropathy and myoblastoma. GO annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for NPRL3 Gene
As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.