Aliases for NPRL2 Gene
External Ids for NPRL2 Gene
Previous HGNC Symbols for NPRL2 Gene
GeneCards Summary for NPRL2 Gene
NPRL2 (NPR2-Like, GATOR1 Complex Subunit) is a Protein Coding gene. Diseases associated with NPRL2 include lung cancer. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cardiac conduction. GO annotations related to this gene include protein kinase activity and GTPase activator activity.
UniProtKB/Swiss-Prot for NPRL2 Gene
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at Tyr-9, Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.