Aliases for NPRL2 Gene
External Ids for NPRL2 Gene
Previous HGNC Symbols for NPRL2 Gene
GeneCards Summary for NPRL2 Gene
NPRL2 (NPR2-Like, GATOR1 Complex Subunit) is a Protein Coding gene. Diseases associated with NPRL2 include lung cancer. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein kinase activity and GTPase activator activity.
UniProtKB/Swiss-Prot for NPRL2 Gene
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at Tyr-9, Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.