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Aliases for NPRL2 Gene

Aliases for NPRL2 Gene

  • Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) 2 3
  • Tumor Suppressor Candidate 4 2 3 4
  • NPR2-Like Protein 3 4
  • Gene 21 Protein 3 4
  • G21 Protein 3 4
  • TUSC4 3 4
  • Homologous To Yeast Nitrogen Permease (Candidate Tumor Suppressor) 3
  • Nitrogen Permease Regulator 2-Like Protein 3
  • 2810446G01Rik 3
  • NPR2L, 6
  • NPR2L 3
  • NPR2 3

External Ids for NPRL2 Gene

Previous Symbols for NPRL2 Gene

  • TUSC4

Summaries for NPRL2 Gene

GeneCards Summary for NPRL2 Gene

NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein kinase activity and GTPase activator activity.

UniProtKB/Swiss-Prot for NPRL2 Gene

  • Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at Tyr-9, Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Gene Wiki entry for NPRL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPRL2 Gene

Genomics for NPRL2 Gene

Genomic Location for NPRL2 Gene

Start:
50,347,330 bp from pter
End:
50,351,091 bp from pter
Size:
3,762 bases
Orientation:
Minus strand

Genomic View for NPRL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPRL2 Gene

No data available for Regulatory Elements for NPRL2 Gene

Proteins for NPRL2 Gene

  • Protein details for NPRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTW4-NPRL2_HUMAN
    Recommended name:
    Nitrogen permease regulator 2-like protein
    Protein Accession:
    Q8WTW4
    Secondary Accessions:
    • A8K831
    • Q6FGS2
    • Q9Y249
    • Q9Y497

    Protein attributes for NPRL2 Gene

    Size:
    380 amino acids
    Molecular mass:
    43658 Da
    Quaternary structure:
    • Forms a heterodimer with NPRL3. Interacts with PDPK1. Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.

    Alternative splice isoforms for NPRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPRL2 Gene

Proteomics data for NPRL2 Gene at MOPED

Post-translational modifications for NPRL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPRL2 Gene

No data available for DME Specific Peptides for NPRL2 Gene

Domains for NPRL2 Gene

Protein Domains for NPRL2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NPRL2_HUMAN
Family:
  • Belongs to the NPR2 family.:
    • Q8WTW4
genes like me logo Genes that share domains with NPRL2: view

No data available for Gene Families for NPRL2 Gene

Function for NPRL2 Gene

Molecular function for NPRL2 Gene

UniProtKB/Swiss-Prot Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at Tyr-9, Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Gene Ontology (GO) - Molecular Function for NPRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 18616680
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 18616680
genes like me logo Genes that share ontologies with NPRL2: view

miRNA for NPRL2 Gene

miRTarBase miRNAs that target NPRL2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NPRL2 Gene

Localization for NPRL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPRL2 Gene COMPARTMENTS Subcellular localization image for NPRL2 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for NPRL2 Gene

Pathways for NPRL2 Gene

genes like me logo Genes that share pathways with NPRL2: view

Gene Ontology (GO) - Biological Process for NPRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 18616680
GO:0033673 negative regulation of kinase activity IDA 18616680
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with NPRL2: view

Transcripts for NPRL2 Gene

Unigene Clusters for NPRL2 Gene

Nitrogen permease regulator-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPRL2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: -
SP9:
SP10: - - - -
SP11: - - - - -
SP12:
SP13: - -
SP14: -
SP15: - -
SP16: -
SP17:

Relevant External Links for NPRL2 Gene

GeneLoc Exon Structure for
NPRL2
ECgene alternative splicing isoforms for
NPRL2

Expression for NPRL2 Gene

mRNA expression in normal human tissues for NPRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPRL2 Gene

SOURCE GeneReport for Unigene cluster for NPRL2 Gene Hs.437083

mRNA Expression by UniProt/SwissProt for NPRL2 Gene

Q8WTW4-NPRL2_HUMAN
Tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested
genes like me logo Genes that share expressions with NPRL2: view

Orthologs for NPRL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NPRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPRL2 36
  • 99.65 (n)
  • 99.74 (a)
NPRL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPRL2 36
  • 92.37 (n)
  • 97.63 (a)
NPRL2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPRL2 36
  • 92.63 (n)
  • 98.42 (a)
NPRL2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nprl2 36
  • 89.82 (n)
  • 98.42 (a)
Nprl2 16
Nprl2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPRL2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPRL2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nprl2 36
  • 89.39 (n)
  • 98.42 (a)
chicken
(Gallus gallus)
Aves NPRL2 36
  • 79.49 (n)
  • 85.16 (a)
NPRL2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPRL2 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nprl2-pending-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nprl2 36
  • 74.87 (n)
  • 82.35 (a)
zebrafish
(Danio rerio)
Actinopterygii nprl2 36
  • 72.56 (n)
  • 82.32 (a)
nprl2 37
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000438 36
  • 54.93 (n)
  • 43.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9104 36
  • 56.18 (n)
  • 46.51 (a)
CG9104 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nprl-2 36
  • 43.95 (n)
  • 29.36 (a)
nprl-2 37
  • 24 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR009W 36
  • 46.35 (n)
  • 34.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPR2 36
  • 46.03 (n)
  • 36.11 (a)
NPR2 37
  • 19 (a)
OneToOne
NPR2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01067g 36
  • 44.16 (n)
  • 34.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes npr2 36
  • 43.52 (n)
  • 32.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for NPRL2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPRL2 Gene

ENSEMBL:
Gene Tree for NPRL2 (if available)
TreeFam:
Gene Tree for NPRL2 (if available)

Paralogs for NPRL2 Gene

No data available for Paralogs for NPRL2 Gene

Variants for NPRL2 Gene

Sequence variations from dbSNP and Humsavar for NPRL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2233483 -- 50,348,634(-) GAAGA(A/C)CTCAG intron-variant
rs2233484 -- 50,348,435(-) CAGGC(A/C)CCTAT intron-variant
rs34059532 -- 50,348,221(+) ATCCC(C/G)GAGAC reference, missense
rs34319036 -- 50,348,633(+) CCTGA(-/G)GTCTT intron-variant
rs78491479 -- 50,348,172(+) GGTCT(C/T)GCACG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NPRL2 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897

Relevant External Links for NPRL2 Gene

HapMap Linkage Disequilibrium report
NPRL2

Disorders for NPRL2 Gene

UniProtKB/Swiss-Prot

NPRL2_HUMAN
  • Note=Inactivating mutations and truncating deletions in the genes encoding GATOR1 proteins, including NPRL2, are detected in glioblastoma and ovarian tumors and are associated with loss of heterozygosity events. Inactivation of GATOR1 proteins promotes constitutive localization of mTORC1 to the lysosomal membrane and blocks mTORC1 inactivation following amino acid withdrawal (PubMed:23723238). {ECO:0000269 PubMed:23723238}.

No disorders were found for NPRL2 Gene.

Publications for NPRL2 Gene

  1. TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. (PMID: 18616680) Kurata A. … Fujita N. (Cancer Sci. 2008) 3 4 23
  2. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4
  3. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. (PMID: 11980673) Ji L. … Minna J.D. (Cancer Res. 2002) 3 4
  4. Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. (PMID: 20193080) Senchenko V.N. … Zabarovsky E.R. (BMC Cancer 2010) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NPRL2 Gene

  • Addgene plasmids for NPRL2

Sources for NPRL2 Gene

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