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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPRL2 Gene

protein-coding   GIFtS: 50
GCID: GC03M050384

nitrogen permease regulator-like 2 (S. cerevisiae)

(Previous name: tumor suppressor candidate 4 )
(Previous symbol: TUSC4)
 Explore 3 diseases affiliated with
NPRL2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for NPRL2    

Aliases
for NPRL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)1 2     G21 Protein2 3
Tumor Suppressor Candidate 41 2 3     NPR2-Like Protein2 3
TUSC41 2 3     2810446G01Rik2
NPR2L1 2 5     Homologous To Yeast Nitrogen Permease (Candidate Tumor Suppressor)2
NPR21 2     Nitrogen Permease Regulator 2-Like Protein2
Gene 21 Protein2 3     

External Ids:    HGNC: 249691   Entrez Gene: 106412   Ensembl: ENSG000001143887   OMIM: 6070725   UniProtKB: Q8WTW43   

Export aliases for NPRL2 gene to outside databases


Summaries
for NPRL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4
Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling.
Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376
residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs

summary for NPRL2:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPRL2 (TUSC4)


Genomic Views
for NPRL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPRL2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPRL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPRL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPRL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

NPRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPRL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050384:  view genomic region     (about GC identifiers)

Start:
 50,384,761 bp from pter      End:
 50,388,522 bp from pter
Size:
 3,762 bases      Orientation:
 minus strand

Proteins
for NPRL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4 (See protein sequence)
Recommended Name: Nitrogen permease regulator 2-like protein  
Size: 380 amino acids; 43658 Da
Subunit: Forms a heterodimer with NPRL3. Interacts with PDPK1
Secondary accessions: A8K831 Q6FGS2 Q9Y249 Q9Y497
Alternative splicing: 2 isoforms:  Q8WTW4-1   Q8WTW4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPRL2: NX_Q8WTW4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WTW4

    • NPRL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006536.3  
    ENSEMBL proteins: 
     ENSP00000232501   ENSP00000412779   ENSP00000388358   ENSP00000388019   ENSP00000396172  
     ENSP00000415045   ENSP00000389429  

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    OriGene Protein Over-expression Lysate: NPRL2
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    Novus Biologicals NPRL2 Protein
    Novus Biologicals NPRL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPRL2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--


    NPRL2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NPRL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPRL2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009348 NPR2

    Graphical View of Domain Structure for InterPro Entry Q8WTW4

    ProtoNet protein and cluster: Q8WTW4

    1 Blocks protein family: IPB009348 Nitrogen permease regulator 2

    UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4
    Similarity: Belongs to the NPR2 family


    Function
    for NPRL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4
    Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling.
    Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376
    residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NPRL2:
    hsa-miR-203
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    Inhib. RNA
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    OriGene shRNA RFP: NPRL2
    OriGene siRNA: NPRL2
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA18616680
    GO:0005515protein binding IPI18616680


    NPRL2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NPRL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPRL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/37 Interacting proteins for NPRL2 (Q8WTW41, 2, 3 ENSP000002325014) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPRL3Q129801, 3, ENSP000003828344EBI-1043552,EBI-2650314 I2D: score=2 STRING: ENSP00000382834
    PRKAR1AP106441, 3, ENSP000003514104EBI-1043552,EBI-476431 I2D: score=2 STRING: ENSP00000351410
    UBE2MP610811, 3, ENSP000002530234EBI-1043552,EBI-1041660 I2D: score=2 STRING: ENSP00000253023
    ANXA7P200732, 3MINT-8248892 I2D: score=2 
    CDKN1AP389362, 3MINT-8252395 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA18616680
    GO:0033673negative regulation of kinase activity IDA18616680


    NPRL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPRL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPRL2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2[127869-51-6]
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]
    Search CenterWatch for drugs/clinical trials and news about NPRL2 

    Transcripts
    for NPRL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPRL2 gene: 
    NM_006545.4  

    Unigene Cluster for NPRL2:

    Nitrogen permease regulator-like 2 (S. cerevisiae)
    Hs.437083  [show with all ESTs]
    Unigene Representative Sequence: BC050412
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476064 ENST00000487632 ENST00000461020 ENST00000467294 ENST00000232501(uc003daj.1)
    ENST00000429366 ENST00000480296 ENST00000451194 ENST00000493465 ENST00000479512
    ENST00000433381 ENST00000418825 ENST00000433999 ENST00000492805 ENST00000448302
    ENST00000469839 ENST00000493907

    miRNA
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    hsa-miR-203
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    Inhib. RNA
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    OriGene shRNA RFP: NPRL2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPRL2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF040707.1 AF040708.1 AK098161.1 AK292196.1 AK309658.1 AL833426.1 BC008802.2 BC021984.1 
    BC050412.1 BC056861.1 BC063030.1 CR542035.1 

    22 DOTS entries:

    DT.100884953  DT.85105475  DT.95143047  DT.91842030  DT.316028  DT.101985533  DT.100884949  DT.120873157 
    DT.120872973  DT.120873149  DT.91806556  DT.120873216  DT.91774245  DT.100667977  DT.100884962  DT.95126412 
    DT.120873095  DT.91774242  DT.100884946  DT.100884950  DT.95143005  DT.95143039 

    24/236 AceView cDNA sequences (see all 236):

    BG119712 AA463393 CB216711 AI189426 AI473741 AL535578 AK098161 AA338738 
    CB529321 AU131935 AU098734 AA352547 AA156783 AA827591 AI264460 AA809865 
    BX281783 BE793809 BM720344 AW162723 AI912309 BM764218 CD370155 CA950506 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for NPRL2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
    SP1:                                      -           -           -     -           -                                                                     
    SP2:                                                  -           -     -           -                                                                     
    SP3:                                      -           -     -     -     -           -                                                                     
    SP4:                                                  -                             -                                                                     
    SP5:                                      -           -           -     -           -                                                                     


    ECgene alternative splicing isoforms for NPRL2

    Expression
    for NPRL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPRL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTGGATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NPRL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPRL2

    SOURCE GeneReport for Unigene cluster: Hs.437083

    UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4
    Tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in
    lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested

        SABiosciences Custom PCR Arrays for NPRL2
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    In Situ
    Assay Products:     
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    Orthologs
    for NPRL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NPRL2 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nprl21 , 5 nitrogen permease regulator-like 2 (S. cerevisiae)5
    nitrogen permease regulator-like 21    		 89.82(n)1
    98.42(a)1    		   9 (58.12 cM)5
    560321  NM_018879.21  NP_061367.11 
     1075422095 
    chicken
    (Gallus gallus)    		 Aves RASSF11 Ras association (RalGDS/AF-6) domain family member more 81.47(n)
    89.12(a)    		   425132  XM_422923.2  XP_422923.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NPRL26
    		 --
    		 89(a)
    		 1 ↔ 1
    		 2(150092189-150104488)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nprl2-pending-prov2 nitrogen permase homolog (S. cerevisiae) 76.28(n)    BC041229.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nprl21 nitrogen permease regulator-like 2 (S. cerevisiae) 72.56(n)
    82.32(a)    		   559391  NM_001045847.1  NP_001039312.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG91041 CG9104 56.09(n)
    46.51(a)    		   32677  NM_132946.2  NP_573174.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nprl-21 Protein NPRL-2 43.31(n)
    28.81(a)    		   177532  NM_068825.4  NP_501226.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes NPR2(YEL062W)4
    NPR21    		 Subunit of the conserved Npr2/3 complex that mediates more4
    Npr2p1    		 44.9(n)1
    34.33(a)1    		   5(34407-36254)4
    8566471, 4  NP_010852.41  NP_010852.24 


    ENSEMBL Gene Tree for NPRL2 (if available)
    TreeFam Gene Tree for NPRL2 (if available) 

    Paralogs
    for NPRL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NPRL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in NPRL2 are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs46886791,2
    		C,F,H,--50384758(-) AAATCG/ATCCTG 2 -- us2k1 int112Minor allele frequency- A:0.27NS EA NA CSA WA 1468
    rs46887231,2
    		C--50384789(-) TAATTA/CCAAAA 2 -- int1 us2k11Minor allele frequency- C:0.00NA 2
    rs1927185611,2
    		--50384796(+) ATTAAC/TCGGCA 2 -- us2k1 int10--------
    rs349637341,2
    		C,--50384978(+) TATGAC/-AAGCC 2 -- ut31 us2k11Minor allele frequency- -:0.50CSA 2
    rs2013906381,2
    		C--50384978(+) TATGAA/CAAGCC 2 -- ut31 us2k10--------
    rs754716171,2
    		C,--50385072(+) ATTTTA/CAAGCC 3 E * stg1 us2k10--------
    rs2018578531,2
    		--50385114(+) GTGGGA/GTGGTG 2 -- us2k1 int10--------
    rs2006009541,2
    		--50385153(+) CACCCG/TGCCCT 2 -- int1 us2k10--------
    rs2000986451,2
    		--50385361(+) GGTGAC/TGCCCT 1 -- int10--------
    rs1489533961,2
    		C,--50385367(+) GCCCTA/GGCCAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NPRL2 (50384761 - 50388522 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPRL2: --

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    Disorders / Diseases
    for NPRL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPRL2 for disorders           About GeneDecksing

    OMIM gene information: 607072    OMIM disorders: --

    3 diseases for NPRL2:    About MalaCards
    nephrotic syndrome    lung cancer    schizophrenia


    Export disorders for NPRL2 gene to outside databases

    Publications
    for NPRL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPRL2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NPRL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2, 3 Lerman M.I. and Minna J.D. (2000)
    2. TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. (PubMed id 18616680)1, 2, 9 Kurata A.... Fujita N. (2008)
    3. A genome-wide screen for regulators of TORC1 in respo nse to amino acid starvation reveals a conserved Npr2/3 complex. (PubMed id 19521502)1, 2 Neklesa T.K. and Davis R.W. (2009)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. (PubMed id 11980673)1, 2 Ji L....Minna J.D. (2002)
    8. Simultaneous down-regulation of tumor suppressor gene s RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. (PubMed id 20193080)1, 9 Senchenko V.N....Zabarovsky E.R. (2010)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for NPRL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing NPRL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10641 HGNC: 24969 AceView: TUSC4 Ensembl:ENSG00000114388 euGenes: HUgn10641
    ECgene: NPRL2 H-InvDB: NPRL2

    Other Databases showing NPRL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPRL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPRL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPRL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPRL2 gene:
    Search GeneIP for patents involving NPRL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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