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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NPRL2 Gene

protein-coding GIFtS: 51
GCID: GC03M050384

Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)

(Previous name: tumor suppressor candidate 4)
(Previous symbol: TUSC4)

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)¹ ²		NPR2L² ⁵
Tumor Suppressor Candidate 4¹ ² ³		2810446G01Rik²
TUSC4¹ ² ³		NPR2²
Gene 21 Protein² ³		Homologous To Yeast Nitrogen Permease (Candidate Tumor Suppressor)²
G21 Protein² ³		Nitrogen Permease Regulator 2-Like Protein²
NPR2-Like Protein² ³

External Ids:	HGNC: 24969¹	Entrez Gene: 10641²	Ensembl: ENSG00000114388⁷	OMIM: 607072⁵	UniProtKB: Q8WTW4³

Export aliases for NPRL2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPRL2 Gene:

NPRL2 (nitrogen permease regulator-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with NPRL2 include nephrotic syndrome, and lung cancer. GO annotations related to this gene include protein binding and protein kinase activity.

UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4

Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling.

Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376

residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs

summary for NPRL2 Gene:

Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl

cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved

catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind

alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying

affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is

in homeostasis of body fluid volume.

Gene Wiki entry for NPRL2 (TUSC4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NT_022517.18 NC_018914.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NPRL2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPRL2 promoter sequence

Search SABiosciences Chromatin IP Primers for NPRL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPRL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

NPRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPRL2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050384: view genomic region (about GC identifiers)

Start:	50,384,761 bp from pter	End:	50,388,522 bp from pter
Size:	3,762 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4 (See protein sequence)

Recommended Name: Nitrogen permease regulator 2-like protein

Size: 380 amino acids; 43658 Da

Subunit: Forms a heterodimer with NPRL3. Interacts with PDPK1

Secondary accessions: A8K831 Q6FGS2 Q9Y249 Q9Y497

Alternative splicing: 2 isoforms: Q8WTW4-1 Q8WTW4-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPRL2: NX_Q8WTW4

Explore proteomics data for NPRL2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8WTW4

NPRL2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_006536.3

ENSEMBL proteins:

ENSP00000232501 ENSP00000412779 ENSP00000388358 ENSP00000388019 ENSP00000396172

ENSP00000415045 ENSP00000389429

Human Recombinant Protein Products for NPRL2:

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	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--

NPRL2 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR009348 NPR2

Graphical View of Domain Structure for InterPro Entry Q8WTW4

ProtoNet protein and cluster: Q8WTW4

1 Blocks protein domain: IPB009348 Nitrogen permease regulator 2

UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4

Similarity: Belongs to the NPR2 family

NPRL2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NPRL2_HUMAN, Q8WTW4

Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling.

Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376

residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IDA	18616680
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	18616680

NPRL2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for NPRL2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPRL2

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPRL2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate NPRL2:
		hsa-miR-203
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NPRL2
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		GenScript: all cDNA clones in your preferred vector: NPRL2 (NM_006545)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPRL2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NPRL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/37 Interacting proteins for NPRL2 (Q8WTW4^{1, 2, 3} ENSP00000232501⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NPRL3	Q12980¹^,³, ENSP00000382834⁴	EBI-1043552,EBI-2650314 I2D: score=2 STRING: ENSP00000382834
PRKAR1A	P10644¹^,³, ENSP00000351410⁴	EBI-1043552,EBI-476431 I2D: score=2 STRING: ENSP00000351410
UBE2M	P61081¹^,³, ENSP00000253023⁴	EBI-1043552,EBI-1041660 I2D: score=2 STRING: ENSP00000253023
ANXA7	P20073²^,³	MINT-8248892 I2D: score=2
CDKN1A	P38936²^,³	MINT-8252395 I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	18616680
GO:0033673	negative regulation of kinase activity	IDA	18616680

NPRL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NPRL2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Brain natriuretic peptide (1-32) (human)	Endogenous peptide agonist at ANP receptor A (NPR1)	[124584-08-3]
C-type natriuretic peptide (1-22) (human, rat, swine)	Endogenous peptide agonist at NPR2	[127869-51-6]
Atrial natriuretic factor (1-28) (human, porcine)	Endogenous peptide regulating blood pressure	[91917-63-4]
Atrial natriuretic factor (1-28) (rat)	Endogenous peptide regulating blood pressure	[88898-17-3]

Search CenterWatch for drugs/clinical trials and news about NPRL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NPRL2 gene:

NM_006545.4

Unigene Cluster for NPRL2:

Nitrogen permease regulator-like 2 (S. cerevisiae)

Hs.437083 [show with all ESTs]

Unigene Representative Sequence: BC050412

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000476064 ENST00000487632 ENST00000461020 ENST00000467294 ENST00000232501(uc003daj.1)

ENST00000429366 ENST00000480296 ENST00000451194 ENST00000493465 ENST00000479512

ENST00000433381 ENST00000418825 ENST00000433999 ENST00000492805 ENST00000448302

ENST00000469839 ENST00000493907

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPRL2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate NPRL2:
		hsa-miR-203
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NPRL2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NPRL2

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Additional mRNA sequence:

AF040707.1 AF040708.1 AK098161.1 AK292196.1 AK309658.1 AL833426.1 BC008802.2 BC021984.1

BC050412.1 BC056861.1 BC063030.1 CR542035.1

22 DOTS entries:

DT.100884953 DT.85105475 DT.95143047 DT.91842030 DT.316028 DT.101985533 DT.100884949 DT.120873157

DT.120872973 DT.120873149 DT.91806556 DT.120873216 DT.91774245 DT.100667977 DT.100884962 DT.95126412

DT.120873095 DT.91774242 DT.100884946 DT.100884950 DT.95143005 DT.95143039

24/236 AceView cDNA sequences (see all 236):

CB529321 AU103076 AA338738 BM474122 AI473741 AU098734 BG119712 CB216711

AU131935 AA463393 BQ061866 AI338001 BQ051194 CA443579 AK098161 BI914754

AI189426 BC050412 BC056861 AA809864 AA398362 AI122589 BC063030 CR604291

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for NPRL2 (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12
SP1:													-				-				-		-				-
SP2:																	-				-		-				-
SP3:													-				-		-		-		-				-
SP4:																	-										-
SP5:													-				-				-		-				-

ECgene alternative splicing isoforms for NPRL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NPRL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGCTGGATGA

About this image

See NPRL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPRL2

SOURCE GeneReport for Unigene cluster: Hs.437083

UniProtKB/Swiss-Prot: NPRL2_HUMAN, Q8WTW4

Tissue specificity: Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in

lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested

SABiosciences Custom PCR Arrays for NPRL2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPRL2

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NPRL2 gene from 8/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nprl2^{1 , 5}	nitrogen permease regulator-like 2 (S. cerevisiae)⁵ nitrogen permease regulator-like 2¹	89.82(n)¹ 98.42(a)¹		9 (58.12 cM)⁵ 56032¹ NM_018879.2¹ NP_061367.1¹ 107542209⁵
chicken (Gallus gallus)	Aves	RASSF1¹	Ras association (RalGDS/AF-6) domain family member more	81.47(n) 89.12(a)		425132 XM_422923.2 XP_422923.2
lizard (Anolis carolinensis)	Reptilia	NPRL2⁶	Uncharacterized protein	89(a)	1 ↔ 1	2(150090887-150107728)
African clawed frog (Xenopus laevis)	Amphibia	nprl2-pending-prov²	nitrogen permase homolog (S. cerevisiae)	76.28(n)		BC041229.1
zebrafish (Danio rerio)	Actinopterygii	nprl2¹	nitrogen permease regulator-like 2 (S. cerevisiae)	72.56(n) 82.32(a)		559391 NM_001045847.1 NP_001039312.1
fruit fly (Drosophila melanogaster)	Insecta	CG9104¹	CG9104	56.09(n) 46.51(a)		32677 NM_132946.2 NP_573174.1
worm (Caenorhabditis elegans)	Secernentea	nprl-2¹	Protein NPRL-2	43.31(n) 28.81(a)		177532 NM_068825.4 NP_501226.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NPR2(YEL062W)⁴ NPR2¹	Subunit of the conserved Npr2/3 complex that mediates more⁴ Npr2p¹	44.9(n)¹ 34.33(a)¹		5(34407-36254)⁴ 856647^{1, 4} NP_010852.4¹ NP_010852.2⁴

ENSEMBL Gene Tree for NPRL2 (if available)
TreeFam Gene Tree for NPRL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200098645^1,2		--	50385361(+)	`GGTGAC/TGCCCT`	1	--	int¹		0	--	--	--	--
rs148953396^1,2	C	--	50385367(+)	`GCCCTA/GGCCAG`	1	--	int¹		0	--	--	--	--
rs201727953^1,2		--	50385525(+)	`TAACTC/TCCAAA`	1	--	int¹		0	--	--	--	--
rs202235498^1,2		--	50385572(+)	`TGCTGC/TAGCTG`	2	L	syn¹		0	--	--	--	--
rs78491479^1,2	C	--	50385603(+)	`GGTCTC/TGCACG`	2	Q R	mis¹		1		NA	4538
rs34059532^1,2	C	--	50385652(+)	`ATCCCC/GGAGAC`	2	R G	mis¹		0	--	--	--	--
rs145729838^1,2	C	--	50385700(+)	`CATCAA/TGTGGC`	1	--	int¹		0	--	--	--	--
rs141770511^1,2	C,F	--	50385836(+)	`ACATTG/AGAGTA`	2	/S	syn¹		1		NA	4548
rs2233484^1,2	C,H	--	50385866(-)	`CAGGCC/ACCTAT`	1	--	int¹		9		NA EA NS	764
rs193060864^1,2	C	--	50385919(+)	`GCCACA/TTGATC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NPRL2 (50384761 - 50388522 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for NPRL2: About this table

Variant ID	Type	Subtype	PubMed ID
dgv5132n71	CNV	Loss	21882294
nsv523662	CNV	Loss	19592680
nsv876770	CNV	Loss	21882294
dgv5131n71	CNV	Loss	21882294
nsv876769	CNV	Loss	21882294
nsv834692	CNV	Loss	17160897
nsv470561	CNV	Loss	18288195
nsv834693	CNV	Loss	17160897
nsv460531	CNV	Loss	19166990

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPRL2

DNA2.0 Custom Variant and Variant Library Synthesis for NPRL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NPRL2 for disorders           About GeneDecksing

OMIM gene information: 607072    OMIM disorders: --

3 diseases for NPRL2:    About MalaCards

nephrotic syndrome lung cancer schizophrenia

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPRL2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NPRL2)

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The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)^{1, 2, 3} Lerman M.I. and Minna J.D. (2000)
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. (PubMed id 18616680)^{1, 2, 9} Kurata A.... Fujita N. (2008)
A genome-wide screen for regulators of TORC1 in respo nse to amino acid starvation reveals a conserved Npr2/3 complex. (PubMed id 19521502)^{1, 2} Neklesa T.K. and Davis R.W. (2009)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)^{1, 2} Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. (PubMed id 11980673)^{1, 2} Ji L....Minna J.D. (2002)
Simultaneous down-regulation of tumor suppressor gene s RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer. (PubMed id 20193080)^{1, 9} Senchenko V.N....Zabarovsky E.R. (2010)
Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)¹ Taipale M....Lindquist S. (2012)
NPRL2 is an independent prognostic factor of osteosarc oma. (PubMed id 23321467)¹ Gao Y....Fan G. (2012-2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10641	HGNC: 24969	AceView: TUSC4	Ensembl:ENSG00000114388	euGenes: HUgn10641
ECgene: NPRL2	H-InvDB: NPRL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NPRL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NPRL2 gene
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NPRL2 Gene

Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)

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NPRL2 Gene

Nitrogen Permease Regulator-Like 2 (S. Cerevisiae)

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