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Aliases for NPR3 Gene

Aliases for NPR3 Gene

  • Natriuretic Peptide Receptor 3 2 3
  • Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C) 2 3
  • Atrial Natriuretic Peptide Clearance Receptor 3 4
  • Atrial Natriuretic Peptide Receptor Type C 3 4
  • Atrionatriuretic Peptide Receptor C 2 3
  • Guanylate Cyclase C 2 3
  • C5orf23 3 4
  • ANPR-C 3 4
  • ANPRC 3 4
  • ANP-C 3 4
  • NPR-C 3 4
  • NPRC 3 4
  • Chromosome 5 Open Reading Frame 23 2
  • Natriuretic Peptide Receptor C 2
  • GUCY2B 3

External Ids for NPR3 Gene

Previous HGNC Symbols for NPR3 Gene

  • NPRC
  • ANPRC
  • C5orf23

Previous GeneCards Identifiers for NPR3 Gene

  • GC05P032498
  • GC05P033158
  • GC05P032688
  • GC05P032757
  • GC05P032747

Summaries for NPR3 Gene

Entrez Gene Summary for NPR3 Gene

  • This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for NPR3 Gene

NPR3 (Natriuretic Peptide Receptor 3) is a Protein Coding gene. Diseases associated with NPR3 include acromesomelic dysplasia and hypertension, essential. GO annotations related to this gene include protein homodimerization activity and hormone binding.

UniProtKB/Swiss-Prot for NPR3 Gene

  • Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

Tocris Summary for NPR3 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Gene Wiki entry for NPR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR3 Gene

Genomics for NPR3 Gene

Regulatory Elements for NPR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPR3 Gene

Chromosome:
5
Start:
32,689,070 bp from pter
End:
32,791,724 bp from pter
Size:
102,655 bases
Orientation:
Plus strand

Genomic View for NPR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR3 Gene

Proteins for NPR3 Gene

  • Protein details for NPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17342-ANPRC_HUMAN
    Recommended name:
    Atrial natriuretic peptide receptor 3
    Protein Accession:
    P17342
    Secondary Accessions:
    • A2RRD1
    • B4DT84
    • E7EPG9

    Protein attributes for NPR3 Gene

    Size:
    541 amino acids
    Molecular mass:
    59808 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.
    Miscellaneous:
    • Has low affinity for peptide hormones in the absence of bound chloride

    Three dimensional structures from OCA and Proteopedia for NPR3 Gene

    Alternative splice isoforms for NPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPR3 Gene

Proteomics data for NPR3 Gene at MOPED

Post-translational modifications for NPR3 Gene

  • Glycosylation at Asn 86, Asn 293, and Asn 394
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NPR3 Gene

Domains & Families for NPR3 Gene

Gene Families for NPR3 Gene

Graphical View of Domain Structure for InterPro Entry

P17342

UniProtKB/Swiss-Prot:

ANPRC_HUMAN :
  • Belongs to the ANF receptor family.
Family:
  • Belongs to the ANF receptor family.
genes like me logo Genes that share domains with NPR3: view

Function for NPR3 Gene

Molecular function for NPR3 Gene

GENATLAS Biochemistry:
natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete absence,unexpectidly produces skeletal abnormalities in mice
UniProtKB/Swiss-Prot Function:
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

Gene Ontology (GO) - Molecular Function for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 NOT adenylate cyclase activity IBA --
GO:0008528 G-protein coupled peptide receptor activity ISS --
GO:0016941 natriuretic peptide receptor activity IDA 1660465
GO:0017046 peptide hormone binding ISS --
GO:0042562 hormone binding IPI 1660465
genes like me logo Genes that share ontologies with NPR3: view
genes like me logo Genes that share phenotypes with NPR3: view

Animal Models for NPR3 Gene

MGI Knock Outs for NPR3:

Animal Model Products

miRNA for NPR3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPR3 Gene

Localization for NPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPR3 Gene COMPARTMENTS Subcellular localization image for NPR3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane IC 1660465
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPR3: view

Pathways & Interactions for NPR3 Gene

SuperPathways for NPR3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0002158 osteoclast proliferation ISS --
GO:0006171 cAMP biosynthetic process IBA --
GO:0007189 NOT adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with NPR3: view

No data available for Pathways by source and SIGNOR curated interactions for NPR3 Gene

Drugs & Compounds for NPR3 Gene

(20) Drugs for NPR3 Gene - From: NovoSeek, DGIdb, IUPHAR, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nesiritide Approved, Investigational Pharma binder, Target 0
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dopamine Approved Pharma Full agonist, Agonist 2814
Isoproterenol Approved Pharma Full agonist, Agonist 15
Nitric Oxide Approved Pharma 540

(16) Additional Compounds for NPR3 Gene - From: HMDB, IUPHAR, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]ANP
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
AP 811
124833-45-0
Atrial natriuretic factor (1-28) (human, porcine)
91917-63-4
genes like me logo Genes that share compounds with NPR3: view

Transcripts for NPR3 Gene

Unigene Clusters for NPR3 Gene

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:

Relevant External Links for NPR3 Gene

GeneLoc Exon Structure for
NPR3
ECgene alternative splicing isoforms for
NPR3

Expression for NPR3 Gene

mRNA expression in normal human tissues for NPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR3 Gene

This gene is overexpressed in Kidney - Cortex (x4.7) and Heart - Atrial Appendage (x4.0).

Protein differential expression in normal tissues from HIPED for NPR3 Gene

This gene is overexpressed in Urine (49.9) and Plasma (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPR3 Gene



SOURCE GeneReport for Unigene cluster for NPR3 Gene Hs.13528

genes like me logo Genes that share expression patterns with NPR3: view

Protein tissue co-expression partners for NPR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NPR3 Gene

Orthologs for NPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPR3 35
  • 89.8 (n)
  • 93.84 (a)
NPR3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPR3 35
  • 85.87 (n)
  • 87.92 (a)
NPR3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npr3 35
  • 86.79 (n)
  • 91.4 (a)
Npr3 16
Npr3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPR3 35
  • 99.88 (n)
  • 99.81 (a)
NPR3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npr3 35
  • 87.1 (n)
  • 91.96 (a)
oppossum
(Monodelphis domestica)
Mammalia NPR3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPR3 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPR3 35
  • 78.03 (n)
  • 80.17 (a)
NPR3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPR3 36
  • 21 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npr3 35
  • 74.91 (n)
  • 75.68 (a)
Str.10435 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.689 35
zebrafish
(Danio rerio)
Actinopterygii npr3 35
  • 61.67 (n)
  • 57.82 (a)
npr3 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14877 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
Species with no ortholog for NPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPR3 Gene

ENSEMBL:
Gene Tree for NPR3 (if available)
TreeFam:
Gene Tree for NPR3 (if available)

Paralogs for NPR3 Gene

(1) SIMAP similar genes for NPR3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NPR3: view

No data available for Paralogs for NPR3 Gene

Variants for NPR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NPR3 Gene

Variant ID Type Subtype PubMed ID
dgv1792e1 CNV Complex 17122850
nsv329020 CNV Loss 16902084
nsv329971 CNV Loss 16902084
nsv520364 CNV Loss 19592680
esv2451636 CNV Deletion 19546169
nsv507242 CNV Insertion 20534489
nsv881099 CNV Gain 21882294
nsv881560 CNV Gain 21882294

Variation tolerance for NPR3 Gene

Residual Variation Intolerance Score: 30.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPR3 Gene

HapMap Linkage Disequilibrium report
NPR3
Human Gene Mutation Database (HGMD)
NPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NPR3 Gene

Disorders for NPR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPR3 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
acromesomelic dysplasia
  • acromesomelic dwarfism
hypertension, essential
  • hypertension, essential 3
- elite association
Search NPR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPR3

Genetic Association Database (GAD)
NPR3
Human Genome Epidemiology (HuGE) Navigator
NPR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPR3
genes like me logo Genes that share disorders with NPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPR3 Gene

Publications for NPR3 Gene

  1. Sequencing and cardiac expression of natriuretic peptide receptors A and C in normal and heart failure pigs. (PMID: 20171990) Cabiati M. … Del Ry S. (Regul. Pept. 2010) 23 67
  2. CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. (PMID: 20178049) Rose R.A. (Curr Opin Investig Drugs 2010) 23 67
  3. C-type natriuretic peptide receptor expression in pancreatic alpha cells. (PMID: 19352691) Burgess M.D. … Gower W.R. (Histochem. Cell Biol. 2009) 23 67
  4. Expression, purification, and characterization of the intra-cellular domain of the ANP receptor. (PMID: 19393286) Pattanaik P. … van den Akker F. (Biochimie 2009) 23 67
  5. Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK. (PMID: 19252090) Arejian M. … Anand-Srivastava M.B. (Am. J. Physiol. Heart Circ. Physiol. 2009) 23 67

Products for NPR3 Gene

Sources for NPR3 Gene

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