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NPR3 Gene

protein-coding   GIFtS: 64
GCID: GC05P032689

Natriuretic Peptide Receptor 3

(Previous names: chromosome 5 open reading frame 23, atrionatriuretic peptide...)
(Previous symbols: NPRC, ANPRC, C5orf23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natriuretic Peptide Receptor 31 2     Atrial Natriuretic Peptide Receptor Type C2 3
ANPRC1 2 3 5     ANP-C2 3
C5orf231 2 3     ANPR-C2 3
NPRC1 2 3     NPR-C2 3
Atrionatriuretic Peptide Receptor C1 2     Chromosome 5 Open Reading Frame 231
Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic
Peptide Receptor C)1 2
     Natriuretic Peptide Receptor C1
Guanylate Cyclase C1 2     GUCY2B2
Atrial Natriuretic Peptide Clearance Receptor2 3     Atrial Natriuretic Peptide Receptor 32

External Ids:    HGNC: 79451   Entrez Gene: 48832   Ensembl: ENSG000001133897   OMIM: 1089625   UniProtKB: P173423   

Export aliases for NPR3 gene to outside databases

Previous GC identifers: GC05P032498 GC05P033158 GC05P032688 GC05P032757 GC05P032747


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPR3 Gene:
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which
regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and
growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing
circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript
variants encoding different isoforms have been found for this gene.(provided by RefSeq, Feb 2011)

GeneCards Summary for NPR3 Gene:
NPR3 (natriuretic peptide receptor 3) is a protein-coding gene. Diseases associated with NPR3 include hypertension, salt-resistant, and acromesomelic dysplasia. GO annotations related to this gene include protein homodimerization activity and hormone binding.

UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342
Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic
peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a
clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate
diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

summary for NPR3 Gene:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPR3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   YY1   HEN1   POU2F1   E2F   E2F-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NPR3 promoter sequence
   Search Chromatin IP Primers for NPR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.3

NPR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPR3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P032689:  view genomic region     (about GC identifiers)

Start:
32,689,176 bp from pter      End:
32,791,830 bp from pter
Size:
102,655 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342 (See protein sequence)
Recommended Name: Atrial natriuretic peptide receptor 3 precursor  
Size: 541 amino acids; 59808 Da
Subunit: Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2
Miscellaneous: Has low affinity for peptide hormones in the absence of bound chloride
4 PDB 3D structures from and Proteopedia for NPR3:
1JDN (3D)        1JDP (3D)        1YK0 (3D)        1YK1 (3D)    
Secondary accessions: A2RRD1 B4DT84 E7EPG9
Alternative splicing: 3 isoforms:  P17342-1   P17342-2   P17342-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPR3: NX_P17342

Explore proteomics data for NPR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn86, Asn293, Asn394
  • Modification sites at PhosphoSitePlus

  • See NPR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000899.1  NP_001191304.1  NP_001191305.1  

    ENSEMBL proteins: 
     ENSP00000425325   ENSP00000388408   ENSP00000265074   ENSP00000398028   ENSP00000423730  
     ENSP00000402490  

    NPR3 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NPR3
    OriGene Protein Over-expression Lysate for NPR3
    OriGene MassSpec for NPR3
    OriGene Custom Protein Services for NPR3
    GenScript Custom Purified and Recombinant Proteins Services for NPR3
    Novus Biologicals NPR3 Protein
    Novus Biologicals NPR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPR3

    NPR3 Antibody Products:

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    Novus Biologicals NPR3 Antibodies
    Abcam antibodies for NPR3
    Cloud-Clone Corp. Antibodies for NPR3
    ThermoFisher Antibody for NPR3
    LSBio Antibodies in human, mouse, rat for NPR3

    NPR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPR3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPR3
    Cloud-Clone Corp. CLIAs for NPR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NPR-C
    Natriuretic peptide receptor family

    3 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR001828 ANF_lig-bd_rcpt
     IPR001170 Ntpep_rcpt

    Graphical View of Domain Structure for InterPro Entry P17342

    ProtoNet protein and cluster: P17342

    2 Blocks protein domains:
    IPB001170 Natriuretic peptide receptor
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342
    Similarity: Belongs to the ANF receptor family


    NPR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANPRC_HUMAN, P17342
    Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic
    peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a
    clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate
    diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

         Genatlas biochemistry entry for NPR3:
    natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating
    natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete
    absence,unexpectidly produces skeletal abnormalities in mice

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008528G-protein coupled peptide receptor activity ISS--
    GO:0016941natriuretic peptide receptor activity IDA1660465
    GO:0017046peptide hormone binding ISS--
    GO:0042562hormone binding IPI1660465
    GO:0042803protein homodimerization activity IEA--
         
    NPR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPR3:
     Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Npr3):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  renal/urinary system  reproductive system  skeleton  vision/eye 

    NPR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Npr3tm1Unc for NPR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPR3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NPR3:
    hsa-mir-30a-5p (MIRT005159), hsa-mir-98-5p (MIRT027551), hsa-mir-335-5p (MIRT017512), hsa-mir-16-5p (MIRT001435)

    Block miRNA regulation of human, mouse, rat NPR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NPR3 (see all 59):
    hsa-miR-323-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-146a hsa-miR-3653 hsa-miR-488 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidNPR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NPR3
    Predesigned siRNA for gene silencing in human, mouse, rat NPR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPR3

    Clone
    Products:
         
    OriGene clones in human, mouse for NPR3 (see all 7)
    OriGene ORF clones in mouse, rat for NPR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NPR3 (NM_000908)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NPR3
    ESI BIO PureStem Progenitor for NPR3: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANPRC_HUMAN, P17342: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IC1660465
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    NPR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NPR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NPR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NPR3 (P173423 ENSP000003980284) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPPAP011603, ENSP000003656634I2D: score=2 STRING: ENSP00000365663
    NPPBP168603, ENSP000003656514I2D: score=2 STRING: ENSP00000365651
    NPPCP235823, ENSP000002954404I2D: score=2 STRING: ENSP00000295440
    NPRL2ENSP000002325014STRING: ENSP00000232501
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ISS--
    GO:0002158osteoclast proliferation ISS--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--

    NPR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Brain natriuretic peptide (1-32) (human)Endogenous peptide agonist at ANP receptor A (NPR1)[124584-08-3]
    C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2[127869-51-6]
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]
    Atrial natriuretic factor (1-28) (rat)Endogenous peptide regulating blood pressure[88898-17-3]

    1 HMDB Compound for NPR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    2 DrugBank Compounds for NPR3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----
    NesiritideBNP (see all 3)124584-08-3target----

    5 IUPHAR Ligands for NPR3 (NPR-C)    About this table
    LigandTypeActionAffinityPubmed IDs
    AP811
    AntagonistAntagonist9.310987424
    [125I]ANP
    NoneNone9.3--
    osteocrin
    AgonistAgonist9.317951249
    M372049
    AntagonistAntagonist9.315337698
    cANF4-23
    AgonistAgonist9.32823385

    Selected Novoseek inferred chemical compound relationships for NPR3 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 78.7 17 15121877 (1), 9379118 (1), 19393286 (1), 20178049 (1) (see all 12)
    guanylate 74.3 9 15134861 (1), 18472099 (1), 8101774 (1), 8172609 (1) (see all 9)
    gf 109203x 38.2 2 16777970 (1), 9428739 (1)
    forskolin 33.2 3 15149737 (2), 15044621 (1)
    isoproterenol 21.9 2 15149737 (1), 15044621 (1)
    sodium 13.9 2 10048495 (1), 11246814 (1)
    ibmx 13.9 1 15149737 (1)
    nitric oxide 8.78 9 10559642 (2), 19252090 (2), 10859228 (1), 16953892 (1)
    actinomycin d 3.17 1 9428739 (1)
    phosphatidylinositol 0.544 4 15911072 (1), 16920814 (1)



    NPR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPR3 gene (4 alternative transcripts): 
    NM_000908.3  NM_001204375.1  NM_001204376.1  NM_024563.3  

    Unigene Cluster for NPR3:

    Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
    Hs.13528  [show with all ESTs]
    Unigene Representative Sequence: NM_001204375
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509104 ENST00000434067 ENST00000506712(uc010iuo.3) ENST00000265074(uc003jhw.2 uc003jhv.3 uc003jhu.3)
    ENST00000415167 ENST00000507141 ENST00000415685
    miRNA
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    Block miRNA regulation of human, mouse, rat NPR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NPR3 (see all 59):
    hsa-miR-323-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-146a hsa-miR-3653 hsa-miR-488 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidNPR3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NPR3
    Predesigned siRNA for gene silencing in human, mouse, rat NPR3
    Clone
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    OriGene clones in human, mouse for NPR3 (see all 7)
    OriGene ORF clones in mouse, rat for NPR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NPR3 (NM_000908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NPR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPR3
      QuantiTect SYBR Green Assays in human, mouse, rat NPR3
      QuantiFast Probe-based Assays in human, mouse, rat NPR3

    Additional mRNA sequence: 

    AF025998.1 AK024116.1 AK290870.1 AK300094.1 AK307217.1 AK308301.1 BC022250.1 BC131540.1 
    M59305.1 X52282.1 

    7 DOTS entries:

    DT.213617  DT.309270  DT.99932051  DT.75111689  DT.91650467  DT.92002000  DT.99969343 

    Selected AceView cDNA sequences (see all 116):

    AI767296 X52282 BM972848 CA412576 AI629003 AI222428 NM_000908 AI628360 
    BX507466 AI075111 BQ017849 AI928027 AA999973 BX103705 BP377256 BM713540 
    BQ002116 BQ776223 AI335695 BM725958 BQ014994 AW275381 BM193762 AA632930 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NPR3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      


    ECgene alternative splicing isoforms for NPR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPR3 expression in normal human tissues (normalized intensities)      NPR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTATAA
    NPR3 Expression
    About this image


    NPR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac Fibroblasts Myocardium
             Endocardium
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Diencephalic Roof Plate
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Presumptive Podocytes Podocyte Layer
             S-shaped Body
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    NPR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13528
        Pathway & Disease-focused RT2 Profiler PCR Array including NPR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NPR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPR3
    QuantiTect SYBR Green Assays in human, mouse, rat NPR3
    QuantiFast Probe-based Assays in human, mouse, rat NPR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPR3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npr31 , 5 natriuretic peptide receptor 31, 5 86.79(n)1
    91.4(a)1
      15 (5.83 cM)5
    181621  NM_001039181.11  NP_001034270.11 
     118398965 
    chicken
    (Gallus gallus)
    Aves NPR31 natriuretic peptide receptor C/guanylate cyclase C more 78.03(n)
    80.17(a)
      431663  XM_004937171.1  XP_004937228.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPR36
    natriuretic peptide receptor C/guanylate cyclase C...
    21(a)
    1 ↔ 1
    AAWZ02036546(21-25225)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6892 Xenopus laevis natriuretic peptide receptor type C more 81.35(n)    AF231035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npr31 natriuretic peptide receptor 3 61.67(n)
    57.82(a)
      569395  NM_001102673.1  NP_001096143.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG148776
    --
    24(a)
    1 ↔ 1
    3R(11714916-11715837)


    ENSEMBL Gene Tree for NPR3 (if available)
    TreeFam Gene Tree for NPR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPR3 gene
    1 SIMAP similar gene for NPR3 using alignment to 4 protein entries:     ANPRC_HUMAN (see all proteins):
    NPRC

    NPR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPR3 (see all 1822)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97167001,2
    C,Funtested132652062(+) AGACGC/AACAGG 3 -- ut51 int1 ese31Minor allele frequency- A:0.20NA 120
    rs1815065261,2
    --32649533(+) TGTGAC/GAAACT 1 -- us2k10--------
    rs7641241,2
    C,F,A--32649647(+) ATCTGG/AGATGG 1 -- us2k19Minor allele frequency- A:0.19NA EA CSA WA 498
    rs1869922221,2
    --32649804(+) GTGGCC/TAGTGG 1 -- us2k10--------
    rs1504391881,2
    C--32649936(+) GTTGT-/TCTTTTT 3 -- us2k10--------
    rs2009753681,2
    --32649947(+) CTTTT-/CTTTTT 3 -- us2k10--------
    rs37629891,2
    C--32649948(-) aaaaaA/Gaaaag 3 -- us2k10--------
    rs2019310951,2
    C--32649950(+) TTTTT-/TCTTTTT 3 -- us2k10--------
    rs1501099061,2
    --32650007(+) GAAAGA/GTTTAA 3 -- us2k10--------
    rs37629881,2
    C,F,A,H--32650083(-) CATCTG/ATATAA 3 -- us2k123Minor allele frequency- A:0.29EA NS WA NA CSA 3827

    HapMap Linkage Disequilibrium report for NPR3 (32689176 - 32791830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NPR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2451636CNV Deletion19546169
    nsv507242CNV Insertion20534489
    nsv329020CNV Loss16902084
    nsv520364CNV Loss19592680
    nsv329971CNV Loss16902084
    nsv881560CNV Gain21882294
    nsv881099CNV Gain21882294
    dgv1792e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NPR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPR3
    DNA2.0 Custom Variant and Variant Library Synthesis for NPR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108962    OMIM disorders: --

    Selected diseases for NPR3 (see all 22):    About MalaCards
    hypertension, salt-resistant    acromesomelic dysplasia    hypertension    panic disorder
    obesity, association with    gigantism    pheochromocytoma    essential hypertension
    neuroendocrine tumor    obesity    lung cancer    medulloblastoma
    pertussis    coronary artery disease    choroiditis    endotheliitis
    asthma    adenoma    hypoxia    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for NPR3:
    Hypertension

    NPR3 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for NPR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 41.7 5 1320540 (1), 8101774 (1), 17475216 (1), 1324959 (1) (see all 5)
    heart failure congestive 39.5 1 8760130 (1)
    essential hypertension 37.2 3 10489108 (1), 15785005 (1)
    pheochromocytoma 11.8 3 10067834 (1), 10871314 (1)
    panic disorder 5.44 1 11532742 (1)
    intrauterine growth retardation 4.48 2 7905249 (2)
    cardiovascular diseases 0 1 17475216 (1)
    hypertrophy 0 2 17007826 (1), 15485690 (1)
    small cell lung cancer 0 1 8391389 (1)
    obesity 0 4 14981229 (1), 10048495 (1), 16203929 (1)

    Genetic Association Database (GAD): NPR3
    Human Genome Epidemiology (HuGE) Navigator: NPR3 (18 documents)

    Export disorders for NPR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPR3 gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with NPR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence of the human atrial natriuretic peptide clearance receptor. (PubMed id 2162522)1, 2, 3 Lowe D.G.... Goeddel D.V. (Nucleic Acids Res. 1990)
    2. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. (PubMed id 7727388)1, 2, 9 Stults J.T.... Lowe D.G. (Biochemistry 1994)
    3. Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure. (PubMed id 17890443)1, 4, 9 Vassalle C....Emdin M. (Clin. Chem. 2007)
    4. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PubMed id 16870210)1, 2, 9 He X.-L.... Garcia K.C. (J. Mol. Biol. 2006)
    5. Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. (PubMed id 15785005)1, 4, 9 Aoi N....Matsumoto K. (Hypertens. Res. 2004)
    6. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PubMed id 12872042)1, 4, 9 Pitzalis M.V....Rizzon P. (J. Hypertens. 2003)
    7. Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA. (PubMed id 2169733)1, 2, 9 Porter J.G....Lewicki J.A. (Biochem. Biophys. Res. Commun. 1990)
    8. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4, 9 Fox A.A....Body S.C. (Anesthesiology 2009)
    9. Arterial stiffness, physical activity, and atrial natriuretic Peptide gene polymorphism in older subjects. (PubMed id 18633189)1, 4, 9 Iemitsu M....Matsuda M. (Hypertens. Res. 2008)
    10. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PubMed id 22116950)1, 4 Schuh-Huerta S.M....Reijo Pera R.A. (Hum. Reprod. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4883 HGNC: 7945 AceView: NPR3andFLJ14054 Ensembl:ENSG00000113389 euGenes: HUgn4883
    ECgene: NPR3 H-InvDB: NPR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NPR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NPR3 gene:
    Search GeneIP for patents involving NPR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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