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GIFtS

NPR3 Gene

protein-coding   GIFtS: 64
GCID: GC05P032747

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic...

(Previous name: chromosome 5 open reading frame 23 )
(Previous symbols: NPRC, ANPRC, C5orf23)
 Explore 19 diseases affiliated with
NPR3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPR3    

Aliases
for NPR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide
Receptor C)1 2
     ANP-C2 3
ANPRC1 2 3 5     ANPR-C2 3
C5orf231 2 3     NPR-C2 3
NPRC1 2 3     FLJ140541
GUCY2B1 2     Chromosome 5 Open Reading Frame 231
Atrial Natriuretic Peptide Clearance Receptor2 3     Atrial Natriuretic Peptide Receptor 32
Atrial Natriuretic Peptide Receptor Type C2 3     

External Ids:    HGNC: 79451   Entrez Gene: 48832   Ensembl: ENSG000001133897   OMIM: 1089625   UniProtKB: P173423   

Export aliases for NPR3 gene to outside databases

Previous GC identifers: GC05P032498 GC05P033158 GC05P032688 GC05P032757


Summaries
for NPR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NPR3:
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate
blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth
processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and
extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342
Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide
NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance
receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood
pressure and skeletal development. Does not have guanylate cyclase activity

summary for NPR3:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPR3


Genomic Views
for NPR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPR3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   YY1   HEN1   POU2F1   E2F   E2F-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NPR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p14-p13   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p14-p13

NPR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPR3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P032747:  view genomic region     (about GC identifiers)

Start:
 32,689,176 bp from pter      End:
 32,791,819 bp from pter
Size:
 102,644 bases      Orientation:
 plus strand

Proteins
for NPR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342 (See protein sequence)
Recommended Name: Atrial natriuretic peptide receptor 3 precursor  
Size: 541 amino acids; 59808 Da
Subunit: Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2
Subcellular location: Membrane; Single-pass type I membrane protein
Miscellaneous: Has low affinity for peptide hormones in the absence of bound chloride
4 PDB 3D structures from and Proteopedia for NPR3:
1JDN (3D)        1JDP (3D)        1YK0 (3D)        1YK1 (3D)    
Secondary accessions: A2RRD1 B4DT84 E7EPG9
Alternative splicing: 3 isoforms:  P17342-1   P17342-2   P17342-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPR3: NX_P17342

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17342

    • NPR3 Protein expression data from MOPED and PaxDb:    About this image 
    NPR3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000899.1  NP_001191304.1  NP_001191305.1  

    ENSEMBL proteins: 
     ENSP00000425325   ENSP00000388408   ENSP00000265074   ENSP00000398028   ENSP00000423730  
     ENSP00000402490  

    Human Recombinant Protein Products for NPR3: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NPR3
    OriGene Protein Over-expression Lysate: NPR3
    OriGene Custom Protein Services for NPR3 
    GenScript Custom Purified and Recombinant Proteins Services for NPR3
    Novus Biologicals NPR3 Protein
    Novus Biologicals NPR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPR3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane IC1660465
    GO:0016021integral to membrane ----

    NPR3 for ontologies           About GeneDecksing



    NPR3 Antibody Products: 
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    Novus Biologicals NPR3 Antibodies
    Abcam antibodies for NPR3 
    Uscn Antibodies for NPR3
    ThermoFisher Antibody for NPR3

    Assay Products for NPR3: 
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    Uscn ELISAs and CLIAs for NPR3

    Protein Domains /
    Families
    for NPR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPR3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001828 ANF_lig-bd_rcpt
     IPR001170 Ntpep_rcpt

    Graphical View of Domain Structure for InterPro Entry P17342

    ProtoNet protein and cluster: P17342

    2 Blocks protein families:
    IPB001170 Natriuretic peptide receptor
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: ANPRC_HUMAN, P17342
    Similarity: Belongs to the ANF receptor family


    Function
    for NPR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANPRC_HUMAN, P17342
    Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide
    NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance
    receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood
    pressure and skeletal development. Does not have guanylate cyclase activity

         Genatlas biochemistry entry for NPR3:
    natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating
    natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete
    absence,unexpectidly produces skeletal abnormalities in mice

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008528G-protein coupled peptide receptor activity ISS--
    GO:0016941natriuretic peptide receptor activity IDA1660465
    GO:0017046peptide hormone binding ISS--
    GO:0042562hormone binding IPI1660465
    GO:0042803protein homodimerization activity IEA--
         
    NPR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPR3:
     Increased gamma-H2AX phosphory 

         15 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Npr3):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  renal/urinary system  reproductive system  skeleton  vision/eye 

    NPR3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Npr3tm1Unc for NPR3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NPR3 

    miRNA
    Products:            		miRTarBase miRNAs that target NPR3:
    hsa-mir-30a (MIRT005159), hsa-mir-16 (MIRT001435)

    OriGene 3'-UTR Clone: NPR3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR3
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR3 (see all 59):
    hsa-miR-323-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-146a hsa-miR-3653 hsa-miR-488 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmid: NPR3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPR3 (see all 7)
    OriGene shRNA RFP: NPR3
    OriGene siRNA: NPR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR3
    Sirion Biotech Custom design and validation of potent shRNA sequences against NPR3 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPR3
    Sirion Biotech Customized adenovirus for overexpression of NPR3 
    Sirion Biotech Customized adenovirus for potent knockdown of NPR3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPR3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NPR3 (NM_000908)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR3 

    Cell Line
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    LifeMap BioReagents: cell line associated with NPR3: PureStem ES-210, Ecto-ntu Progenitor
    Sirion Biotech Customized stable knockdown cell line services for NPR3 
    Sirion Biotech Customized inducible knockdown cell line services for NPR3
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    Sirion Biotech Customized inducible overexpressing cell line services for NPR3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR3


    Pathways & Interactions
    for NPR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NPR3 (P173423 ENSP000003980284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPPAP011603, ENSP000003656634I2D: score=2 STRING: ENSP00000365663
    NPPBP168603, ENSP000003656514I2D: score=2 STRING: ENSP00000365651
    NPPCP235823, ENSP000002954404I2D: score=2 STRING: ENSP00000295440
    NPRL2ENSP000002325014STRING: ENSP00000232501
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ISS--
    GO:0002158osteoclast proliferation ISS--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007194negative regulation of adenylate cyclase activity IEA--
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--

    NPR3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]

    1 HMDB Compound for NPR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    2 DrugBank Compounds for NPR3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----
    NesiritideBNP (see all 3)124584-08-3target----

    10/20 Novoseek chemical compound relationships for NPR3 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 78.7 17 15121877 (1), 9379118 (1), 19393286 (1), 20178049 (1) (see all 12)
    guanylate 74.3 9 15134861 (1), 18472099 (1), 8101774 (1), 8172609 (1) (see all 9)
    gf 109203x 38.2 2 16777970 (1), 9428739 (1)
    forskolin 33.2 3 15149737 (2), 15044621 (1)
    isoproterenol 21.9 2 15149737 (1), 15044621 (1)
    sodium 13.9 2 10048495 (1), 11246814 (1)
    ibmx 13.9 1 15149737 (1)
    nitric oxide 8.78 9 10559642 (2), 19252090 (2), 10859228 (1), 16953892 (1)
    actinomycin d 3.17 1 9428739 (1)
    phosphatidylinositol 0.544 4 15911072 (1), 16920814 (1)

    Search CenterWatch for drugs/clinical trials and news about NPR3 / ANPRC 

    Transcripts
    for NPR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPR3 gene (4 alternative transcripts): 
    NM_000908.3  NM_001204375.1  NM_001204376.1  NM_024563.3  

    Unigene Cluster for NPR3:

    Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
    Hs.13528  [show with all ESTs]
    Unigene Representative Sequence: NM_001204375
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509104 ENST00000434067 ENST00000506712(uc010iuo.3) ENST00000265074(uc003jhw.2 uc003jhv.3 uc003jhu.3)
    ENST00000415167 ENST00000507141 ENST00000415685

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NPR3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR3
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR3 (see all 59):
    hsa-miR-323-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-146a hsa-miR-3653 hsa-miR-488 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmid: NPR3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPR3 (see all 7)
    OriGene shRNA RFP: NPR3
    OriGene siRNA: NPR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR3
    Sirion Biotech Custom design and validation of potent shRNA sequences against NPR3 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPR3
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    GenScript: all cDNA clones in your preferred vector (see all 3): NPR3 (NM_000908)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR3 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPR3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR3

    Additional cDNA sequence: 

    AF025998.1 AK024116.1 AK290870.1 AK300094.1 AK307217.1 AK308301.1 BC022250.1 BC131540.1 
    M59305.1 X52282.1 

    7 DOTS entries:

    DT.213617  DT.309270  DT.99932051  DT.75111689  DT.91650467  DT.92002000  DT.99969343 

    24/116 AceView cDNA sequences (see all 116):

    CA412576 BP377256 AA665821 AI222428 BQ014994 X52282 AI767296 AF025998 
    AI335695 BM193762 AI629003 BQ002116 BX089843 AI628360 AW102877 BM680969 
    BM705008 AW772221 AA632930 BM713540 BM725958 BM972848 AI075111 AA999973 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NPR3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                      
    SP2:                                                      


    ECgene alternative splicing isoforms for NPR3

    Expression
    for NPR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGTATAA
    NPR3 Expression
    About this image

    NPR3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/17 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 17) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPresumptive PodocytesKidney
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    HeartMyocardiumCardiac FibroblastsEpicardium
    KidneyPodocyte LayerPodocytesKidney
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    AdiposeVisceral White AdiposeAdipose
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Beating cell clusters (Spontaneous differen...)

    See NPR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPR3

    SOURCE GeneReport for Unigene cluster: Hs.13528
        SABiosciences Expression via Pathway-Focused PCR Array including NPR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPR3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPR3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR3

    Orthologs
    for NPR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPR3 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Npr31 , 5 natriuretic peptide receptor 31, 5 87(n)1
    91.6(a)1    		   15 (5.83 cM)5
    181621  NM_008728.21  NP_032754.21 
     118398965 
    chicken
    (Gallus gallus)    		 Aves LOC4316631 atrial natriuretic peptide receptor 3-like 77.42(n)
    79.08(a)    		   431663  XM_003642974.1  XP_003643022.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 24(a)
    		 1 ↔ 1
    		 AAWZ02036546(649-24165)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.6892 Xenopus laevis natriuretic peptide receptor type C more 81.35(n)    AF231035.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii npr31 natriuretic peptide receptor 3 60.83(n)
    57.05(a)    		   569395  NM_001102673.1  NP_001096143.1 


    ENSEMBL Gene Tree for NPR3 (if available)
    TreeFam Gene Tree for NPR3 (if available) 

    Paralogs
    for NPR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NPR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1522 NCBI SNPs in NPR3 are shown (see all 1522)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs7641241,2
    		C,F,A--32677047(+) ATCTGG/AGATGG 1 -- us2k19Minor allele frequency- A:0.19NA EA CSA WA 498
    rs38348181,2
    		C--32677766(+) GCGTTA/-AAGGC 3 -- us2k14Minor allele frequency- -:0.28MN EA NA CSA 360
    rs1144165051,2
    		C,F--32678186(+) ACCCCA/GGCACA 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs68684541,2
    		C,A--32678280(+) TACCGG/TGAACG 3 -- us2k12Minor allele frequency- T:0.20WA 120
    rs727406371,2
    		C,F--32678314(+) TTTAGG/ATACCT 3 -- us2k14Minor allele frequency- A:0.30NA CSA WA 242
    rs285130891,2
    		C--32678589(+) CACCAG/AGTCCG 3 -- us2k1 ut512Minor allele frequency- A:0.19NA WA 120
    rs168901331,2
    		F--32678632(+) TTGTTC/TCCTGA 4 F us2k1 syn12Minor allele frequency- T:0.01MN EA 356
    rs97167001,2
    		C,F--32679461(+) AGACGC/AACAGG 3 -- ut51 int1 ese31Minor allele frequency- A:0.20NA 120
    rs1888845651,2
    		C--32679512(+) TTTTTC/TTTTTA 3 -- ut51 int10--------
    rs48674731,2
    		C--32680665(+) CATCGC/TGGTGT 3 -- int14Minor allele frequency- T:0.10CSA WA NA EA 360

    HapMap Linkage Disequilibrium report for NPR3 (32689176 - 32791819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for NPR3
         5 CNVs: 51686 3552 6391 99103 6392
    Human Gene Mutation Database (HGMD): NPR3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPR3
    DNA2.0 Custom Variant and Variant Library Synthesis for NPR3

    Disorders / Diseases
    for NPR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPR3 for disorders           About GeneDecksing

    OMIM gene information: 108962    OMIM disorders: --

    19 diseases for NPR3:    About MalaCards
    hypertension, salt-resistant    hypertension    pulmonary hypertension    acromesomelic dysplasia
    panic disorder    pheochromocytoma    gigantism    obesity, association with
    obesity    lung cancer    aldosteronism    asthma
    medulloblastoma    pertussis    cardiomyopathy    adenoma
    hypoxia    thyroiditis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NPR3:
    Hypertension

    10 Novoseek disease relationships for NPR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 41.7 5 1320540 (1), 8101774 (1), 17475216 (1), 1324959 (1) (see all 5)
    heart failure congestive 39.5 1 8760130 (1)
    essential hypertension 37.2 3 10489108 (1), 15785005 (1)
    pheochromocytoma 11.8 3 10067834 (1), 10871314 (1)
    panic disorder 5.44 1 11532742 (1)
    intrauterine growth retardation 4.48 2 7905249 (2)
    cardiovascular diseases 0 1 17475216 (1)
    hypertrophy 0 2 17007826 (1), 15485690 (1)
    small cell lung cancer 0 1 8391389 (1)
    obesity 0 4 14981229 (1), 10048495 (1), 16203929 (1)

    Genetic Association Database (GAD): NPR3
    Human Genome Epidemiology (HuGE) Navigator: NPR3 (18 documents)

    Export disorders for NPR3 gene to outside databases

    Publications
    for NPR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPR3 gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with NPR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence of the human atrial natriuretic peptide clearance receptor. (PubMed id 2162522)1, 2, 3 Lowe D.G.... Goeddel D.V. (1990)
    2. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. (PubMed id 7727388)1, 2, 9 Stults J.T.... Lowe D.G. (1994)
    3. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PubMed id 16870210)1, 2, 9 He X.-L.... Garcia K.C. (2006)
    4. Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. (PubMed id 15785005)1, 4, 9 Aoi N....Matsumoto K. (2004)
    5. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PubMed id 12872042)1, 4, 9 Pitzalis M.V....Rizzon P. (2003)
    6. Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA. (PubMed id 2169733)1, 2, 9 Porter J.G....Lewicki J.A. (1990)
    7. Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. (PubMed id 15017020)1, 4 Rubattu S....Volpe M. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. (PubMed id 11533490)1, 2 He X.-L.... Garcia K.C. (2001)

    External Searches for NPR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4883 HGNC: 7945 AceView: NPR3andFLJ14054 Ensembl:ENSG00000113389 euGenes: HUgn4883
    ECgene: NPR3 H-InvDB: NPR3

    Other Databases showing NPR3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPR3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPR3 gene:
    Search GeneIP for patents involving NPR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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