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Aliases for NPR3 Gene

Aliases for NPR3 Gene

  • Natriuretic Peptide Receptor 3 2 3
  • ANPRC 3 4 6
  • Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C) 2 3
  • Atrial Natriuretic Peptide Clearance Receptor 3 4
  • Atrial Natriuretic Peptide Receptor Type C 3 4
  • Atrionatriuretic Peptide Receptor C 2 3
  • Guanylate Cyclase C 2 3
  • C5orf23 3 4
  • ANPR-C 3 4
  • ANP-C 3 4
  • NPR-C 3 4
  • NPRC 3 4
  • Atrial Natriuretic Peptide Receptor 3 3
  • Chromosome 5 Open Reading Frame 23 2
  • Natriuretic Peptide Receptor C 2
  • GUCY2B 3

External Ids for NPR3 Gene

Previous Symbols for NPR3 Gene

  • NPRC
  • ANPRC
  • C5orf23

Summaries for NPR3 Gene

Entrez Gene Summary for NPR3 Gene

  • This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for NPR3 Gene

NPR3 (Natriuretic Peptide Receptor 3) is a Protein Coding gene. Diseases associated with NPR3 include pulmonary hypertension and obesity. GO annotations related to this gene include protein homodimerization activity and hormone binding.

UniProtKB/Swiss-Prot for NPR3 Gene

  • Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

Tocris Summary for NPR3 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is in homeostasis of body fluid volume.

Gene Wiki entry for NPR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR3 Gene

Genomics for NPR3 Gene

Genomic Location for NPR3 Gene

Start:
32,689,070 bp from pter
End:
32,791,724 bp from pter
Size:
102,655 bases
Orientation:
Plus strand

Genomic View for NPR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR3 Gene

Regulatory Elements for NPR3 Gene

Proteins for NPR3 Gene

  • Protein details for NPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17342-ANPRC_HUMAN
    Recommended name:
    Atrial natriuretic peptide receptor 3
    Protein Accession:
    P17342
    Secondary Accessions:
    • A2RRD1
    • B4DT84
    • E7EPG9

    Protein attributes for NPR3 Gene

    Size:
    541 amino acids
    Molecular mass:
    59808 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.
    Miscellaneous:
    • Has low affinity for peptide hormones in the absence of bound chloride

    Three dimensional structures from OCA and Proteopedia for NPR3 Gene

    Alternative splice isoforms for NPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPR3 Gene

Proteomics data for NPR3 Gene at MOPED

Post-translational modifications for NPR3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn86, Asn293, and Asn394

No data available for DME Specific Peptides for NPR3 Gene

Domains for NPR3 Gene

Gene Families for NPR3 Gene

UniProtKB/Swiss-Prot:

ANPRC_HUMAN
Family:
  • Belongs to the ANF receptor family.:
    • P17342
genes like me logo Genes that share domains with NPR3: view

Function for NPR3 Gene

Molecular function for NPR3 Gene

GENATLAS Biochemistry: natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete absence,unexpectidly produces skeletal abnormalities in mice
UniProtKB/Swiss-Prot Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity

Gene Ontology (GO) - Molecular Function for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008528 G-protein coupled peptide receptor activity ISS --
GO:0016941 natriuretic peptide receptor activity IDA 1660465
GO:0017046 peptide hormone binding ISS --
GO:0042562 hormone binding IPI 1660465
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with NPR3: view
genes like me logo Genes that share phenotypes with NPR3: view

Animal Models for NPR3 Gene

MGI Knock Outs for NPR3:

miRNA for NPR3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPR3 Gene

Localization for NPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPR3 Gene COMPARTMENTS Subcellular localization image for NPR3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IC 1660465
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NPR3: view

Pathways for NPR3 Gene

SuperPathways for NPR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0002158 osteoclast proliferation ISS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NPR3: view

No data available for Pathways by source for NPR3 Gene

Compounds for NPR3 Gene

(4) Tocris Compounds for NPR3 Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure [91917-63-4]
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure [88898-17-3]
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) [124584-08-3]
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 [127869-51-6]

(1) HMDB Compounds for NPR3 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6

(2) Drugbank Compounds for NPR3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Nesiritide
  • BNP
124584-08-3 target

(5) IUPHAR Ligand for NPR3 Gene

Ligand Type Action Affinity Pubmed IDs
AP811 Antagonist Antagonist 9.3
[125I]ANP None None
osteocrin Agonist Agonist
M372049 Antagonist Antagonist
cANF4-23 Agonist Agonist

(20) Novoseek inferred chemical compound relationships for NPR3 Gene

Compound -log(P) Hits PubMed IDs
cgmp 78.7 12
guanylate 74.3 9
gf 109203x 38.2 2
forskolin 33.2 3
isoproterenol 21.9 2
genes like me logo Genes that share compounds with NPR3: view

Transcripts for NPR3 Gene

Unigene Clusters for NPR3 Gene

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:

Relevant External Links for NPR3 Gene

GeneLoc Exon Structure for
NPR3
ECgene alternative splicing isoforms for
NPR3

Expression for NPR3 Gene

mRNA expression in normal human tissues for NPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR3 Gene

This gene is overexpressed in Kidney - Cortex (4.7) and Heart - Atrial Appendage (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPR3 Gene

SOURCE GeneReport for Unigene cluster for NPR3 Gene Hs.13528

genes like me logo Genes that share expressions with NPR3: view

Orthologs for NPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPR3 36
  • 99.88 (n)
  • 99.81 (a)
NPR3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPR3 36
  • 89.8 (n)
  • 93.84 (a)
NPR3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPR3 36
  • 85.87 (n)
  • 87.92 (a)
NPR3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npr3 36
  • 86.79 (n)
  • 91.4 (a)
Npr3 16
Npr3 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPR3 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPR3 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npr3 36
  • 87.1 (n)
  • 91.96 (a)
chicken
(Gallus gallus)
Aves NPR3 36
  • 78.03 (n)
  • 80.17 (a)
NPR3 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPR3 37
  • 21 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.689 36
tropical clawed frog
(Silurana tropicalis)
Amphibia npr3 36
  • 74.91 (n)
  • 75.68 (a)
Str.10435 36
zebrafish
(Danio rerio)
Actinopterygii npr3 36
  • 61.67 (n)
  • 57.82 (a)
npr3 37
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14877 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
-- 37
  • 29 (a)
OneToMany
Species with no ortholog for NPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPR3 Gene

ENSEMBL:
Gene Tree for NPR3 (if available)
TreeFam:
Gene Tree for NPR3 (if available)

Paralogs for NPR3 Gene

Selected SIMAP similar genes for NPR3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NPR3: view

No data available for Paralogs for NPR3 Gene

Variants for NPR3 Gene

Sequence variations from dbSNP and Humsavar for NPR3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs696151 -- 32,733,834(-) TATGC(A/G)GTGAT intron-variant
rs696831 -- 32,725,425(-) TGCTC(C/T)AATTG intron-variant
rs696832 -- 32,725,439(-) ACATG(A/G)TATCT intron-variant
rs696833 -- 32,726,531(+) GAAAT(A/G)GTGGT intron-variant
rs696834 -- 32,728,288(-) acggg(A/G)tttca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPR3 Gene

Variant ID Type Subtype PubMed ID
dgv1792e1 CNV Complex 17122850
nsv329020 CNV Loss 16902084
nsv329971 CNV Loss 16902084
nsv520364 CNV Loss 19592680
esv2451636 CNV Deletion 19546169
nsv507242 CNV Insertion 20534489
nsv881099 CNV Gain 21882294
nsv881560 CNV Gain 21882294

Relevant External Links for NPR3 Gene

HapMap Linkage Disequilibrium report
NPR3
Human Gene Mutation Database (HGMD)
NPR3

Disorders for NPR3 Gene

(1) University of Copenhagen DISEASES for NPR3 Gene

(10) Novoseek inferred disease relationships for NPR3 Gene

Disease -log(P) Hits PubMed IDs
heart failure 41.7 5
heart failure congestive 39.5 1
essential hypertension 37.2 2
pheochromocytoma 11.8 2
panic disorder 5.44 1

Relevant External Links for NPR3

Genetic Association Database (GAD)
NPR3
Human Genome Epidemiology (HuGE) Navigator
NPR3
genes like me logo Genes that share disorders with NPR3: view

No data available for UniProtKB/Swiss-Prot for NPR3 Gene

Publications for NPR3 Gene

  1. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PMID: 12872042) Pitzalis M.V. … Rizzon P. (J. Hypertens. 2003) 3 23 49
  2. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. (PMID: 7727388) Stults J.T. … Lowe D.G. (Biochemistry 1994) 3 4 23
  3. Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA. (PMID: 2169733) Porter J.G. … Lewicki J.A. (Biochem. Biophys. Res. Commun. 1990) 3 4 23
  4. Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. (PMID: 15785005) Aoi N. … Matsumoto K. (Hypertens. Res. 2004) 3 23 49
  5. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PMID: 16870210) He X.-L. … Garcia K.C. (J. Mol. Biol. 2006) 3 4 23

Products for NPR3 Gene

Sources for NPR3 Gene

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