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Aliases for NPR3 Gene

Aliases for NPR3 Gene

  • Natriuretic Peptide Receptor 3 2 3 5
  • Natriuretic Peptide Receptor C/Guanylate Cyclase C (Atrionatriuretic Peptide Receptor C) 2 3
  • Atrial Natriuretic Peptide Clearance Receptor 3 4
  • Atrial Natriuretic Peptide Receptor Type C 3 4
  • Atrionatriuretic Peptide Receptor C 2 3
  • Guanylate Cyclase C 2 3
  • C5orf23 3 4
  • ANPR-C 3 4
  • ANPRC 3 4
  • ANP-C 3 4
  • NPR-C 3 4
  • NPRC 3 4
  • Atrial Natriuretic Peptide Receptor 3 3
  • Chromosome 5 Open Reading Frame 23 2
  • Natriuretic Peptide Receptor C 2
  • GUCY2B 3

External Ids for NPR3 Gene

Previous HGNC Symbols for NPR3 Gene

  • NPRC
  • ANPRC
  • C5orf23

Previous GeneCards Identifiers for NPR3 Gene

  • GC05P032498
  • GC05P033158
  • GC05P032688
  • GC05P032757
  • GC05P032747

Summaries for NPR3 Gene

Entrez Gene Summary for NPR3 Gene

  • This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for NPR3 Gene

NPR3 (Natriuretic Peptide Receptor 3) is a Protein Coding gene. Diseases associated with NPR3 include Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly and Hypertension, Essential. GO annotations related to this gene include protein homodimerization activity and hormone binding.

UniProtKB/Swiss-Prot for NPR3 Gene

  • Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Tocris Summary for NPR3 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Gene Wiki entry for NPR3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR3 Gene

Genomics for NPR3 Gene

Regulatory Elements for NPR3 Gene

Enhancers for NPR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G032831 0.7 ENCODE 17.1 +142.8 142760 0.2 GTF2F1 TBP MAX CEBPB RAD21 EP300 RFX5 JUND SMC3 STAT3 NPR3 GC05M032746 GC05P032857
GH05G033308 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +622.3 622343 5.4 TBP JUN SREBF2 MAX RAD21 RFX5 GATA3 ELK1 NFYB ZNF350 ENSG00000250697 NPR3 ENSG00000251281 PIR55286
GH05G033369 1.3 FANTOM5 Ensembl ENCODE 5.8 +682.2 682198 3.6 ELK4 STAT1 SMARCC1 JUN MNT SUPT20H EP300 ZKSCAN1 MAFF JUND ENSG00000250697 NPR3 ENSG00000249572 PIR55286
GH05G032851 0.9 Ensembl ENCODE 6.3 +163.6 163582 1.4 CTCF STAT1 BHLHE40 TEAD4 SIN3A NR3C1 RAD21 GLIS1 SMC3 HNF4A NPR3 GC05P032857 GC05M032746
GH05G033343 0.9 FANTOM5 ENCODE 5.9 +655.1 655143 1.6 JUND JUN FOS EP300 MYC RFX5 NPR3 ENSG00000249572 PIR55286 ENSG00000250697
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPR3 Gene

Chromosome:
5
Start:
32,689,070 bp from pter
End:
32,791,724 bp from pter
Size:
102,655 bases
Orientation:
Plus strand

Genomic View for NPR3 Gene

Genes around NPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR3 Gene

Proteins for NPR3 Gene

  • Protein details for NPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17342-ANPRC_HUMAN
    Recommended name:
    Atrial natriuretic peptide receptor 3
    Protein Accession:
    P17342
    Secondary Accessions:
    • A2RRD1
    • B4DT84
    • E7EPG9

    Protein attributes for NPR3 Gene

    Size:
    541 amino acids
    Molecular mass:
    59808 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:11533490). Dimers can also be formed through the C-terminal cysteine of isoform 2 (PubMed:11533490). Interacts with OSTN (By similarity).
    Miscellaneous:
    • Has low affinity for peptide hormones in the absence of bound chloride.

    Three dimensional structures from OCA and Proteopedia for NPR3 Gene

    Alternative splice isoforms for NPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPR3 Gene

Post-translational modifications for NPR3 Gene

  • Glycosylation at posLast=8686, posLast=293293, and posLast=394394
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPR3 Gene

Domains & Families for NPR3 Gene

Gene Families for NPR3 Gene

Graphical View of Domain Structure for InterPro Entry

P17342

UniProtKB/Swiss-Prot:

ANPRC_HUMAN :
  • Belongs to the ANF receptor family.
Family:
  • Belongs to the ANF receptor family.
genes like me logo Genes that share domains with NPR3: view

Function for NPR3 Gene

Molecular function for NPR3 Gene

GENATLAS Biochemistry:
natriuretic peptide,receptor C,widely and abundantly expressed,involved in the systemic clearance of circulating natriuretic peptides and in the control of local effects of the natriuretic peptide system.Its complete absence,unexpectidly produces skeletal abnormalities in mice
UniProtKB/Swiss-Prot Function:
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Gene Ontology (GO) - Molecular Function for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16870210
GO:0008528 G-protein coupled peptide receptor activity ISS --
GO:0016941 natriuretic peptide receptor activity IDA 1660465
GO:0017046 peptide hormone binding ISS --
GO:0031404 chloride ion binding IDA 16870210
genes like me logo Genes that share ontologies with NPR3: view
genes like me logo Genes that share phenotypes with NPR3: view

Animal Models for NPR3 Gene

MGI Knock Outs for NPR3:

Animal Model Products

miRNA for NPR3 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPR3 Gene

Localization for NPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPR3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005887 integral component of plasma membrane IC 1660465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IDA 16870210
genes like me logo Genes that share ontologies with NPR3: view

Pathways & Interactions for NPR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0002158 osteoclast proliferation ISS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NPR3: view

No data available for Pathways by source and SIGNOR curated interactions for NPR3 Gene

Drugs & Compounds for NPR3 Gene

(25) Drugs for NPR3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nesiritide Approved, Investigational Pharma binder, Target 0
AP811 Pharma Antagonist 0
cANF<sup>4-23</sup> Pharma Agonist 0
M372049 Pharma Antagonist 0
osteocrin Pharma Agonist 0

(11) Additional Compounds for NPR3 Gene - From: HMDB, Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]ANP
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
AP 811
124833-45-0

(5) Tocris Compounds for NPR3 Gene

Compound Action Cas Number
AP 811 High affinity, selective NPR3 antagonist 124833-45-0
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure 91917-63-4
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure 88898-17-3
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) 124584-08-3
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 127869-51-6

(1) ApexBio Compounds for NPR3 Gene

Compound Action Cas Number
BNP (1-32), human Brain natriuretic peptide 114471-18-0
genes like me logo Genes that share compounds with NPR3: view

Drug Products

Transcripts for NPR3 Gene

Unigene Clusters for NPR3 Gene

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:

Relevant External Links for NPR3 Gene

GeneLoc Exon Structure for
NPR3
ECgene alternative splicing isoforms for
NPR3

Expression for NPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR3 Gene

This gene is overexpressed in Kidney - Cortex (x4.7) and Heart - Atrial Appendage (x4.0).

Protein differential expression in normal tissues from HIPED for NPR3 Gene

This gene is overexpressed in Urine (49.9) and Plasma (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPR3 Gene



Protein tissue co-expression partners for NPR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPR3 Gene:

NPR3

SOURCE GeneReport for Unigene cluster for NPR3 Gene:

Hs.13528

Evidence on tissue expression from TISSUES for NPR3 Gene

  • Kidney(4.7)
  • Eye(4.1)
  • Heart(2.6)
  • Muscle(2.6)
  • Lung(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with NPR3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPR3 Gene

Orthologs for NPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPR3 34 35
  • 99.88 (n)
oppossum
(Monodelphis domestica)
Mammalia NPR3 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPR3 34 35
  • 89.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPR3 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npr3 34
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Npr3 34 16 35
  • 86.79 (n)
dog
(Canis familiaris)
Mammalia NPR3 34 35
  • 85.87 (n)
chicken
(Gallus gallus)
Aves NPR3 34 35
  • 78.03 (n)
lizard
(Anolis carolinensis)
Reptilia NPR3 35
  • 21 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npr3 34
  • 74.91 (n)
Str.10435 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.689 34
zebrafish
(Danio rerio)
Actinopterygii npr3 34 35
  • 61.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14877 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
Species where no ortholog for NPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPR3 Gene

ENSEMBL:
Gene Tree for NPR3 (if available)
TreeFam:
Gene Tree for NPR3 (if available)

Paralogs for NPR3 Gene

(1) SIMAP similar genes for NPR3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NPR3: view

No data available for Paralogs for NPR3 Gene

Variants for NPR3 Gene

Sequence variations from dbSNP and Humsavar for NPR3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000003665 -- 32,764,332(+) TGCTT(C/G)AGTGC intron-variant
rs1000003704 -- 32,750,082(+) CTGTG(A/T)ACACT intron-variant
rs1000005457 -- 32,722,640(+) AACTT(A/C)CCGGA intron-variant
rs1000021590 -- 32,709,251(+) AACAC(C/T)GGTTC intron-variant, upstream-variant-2KB
rs1000096057 -- 32,753,562(+) ATTCC(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPR3 Gene

Variant ID Type Subtype PubMed ID
esv2451636 CNV deletion 19546169
esv2759338 CNV loss 17122850
esv3604616 CNV gain 21293372
esv3604619 CNV gain 21293372
nsv1017141 CNV gain 25217958
nsv329020 CNV deletion 16902084
nsv329971 CNV deletion 16902084
nsv507242 OTHER sequence alteration 20534489
nsv520364 CNV loss 19592680
nsv950666 CNV deletion 24416366

Variation tolerance for NPR3 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPR3 Gene

Human Gene Mutation Database (HGMD)
NPR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPR3 Gene

Disorders for NPR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
short-rib thoracic dysplasia 5 with or without polydactyly
  • asphyxiating thoracic dystrophy 5
hypertension, essential
  • hypertension, essential 3
- elite association - COSMIC cancer census association via MalaCards
Search NPR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPR3

Genetic Association Database (GAD)
NPR3
Human Genome Epidemiology (HuGE) Navigator
NPR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPR3
genes like me logo Genes that share disorders with NPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPR3 Gene

Publications for NPR3 Gene

  1. Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure. (PMID: 17890443) Vassalle C. … Emdin M. (Clin. Chem. 2007) 3 22 46 64
  2. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PMID: 16870210) He X.-L. … Garcia K.C. (J. Mol. Biol. 2006) 3 4 22 64
  3. Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension. (PMID: 15785005) Aoi N. … Matsumoto K. (Hypertens. Res. 2004) 3 22 46 64
  4. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PMID: 12872042) Pitzalis M.V. … Rizzon P. (J. Hypertens. 2003) 3 22 46 64
  5. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. (PMID: 7727388) Stults J.T. … Lowe D.G. (Biochemistry 1994) 3 4 22 64

Products for NPR3 Gene

Sources for NPR3 Gene

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