Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPR2 Gene

protein-coding   GIFtS: 69
GCID: GC09P035792

Natriuretic Peptide Receptor B/Guanylate Cyclase B (Atrionatriuretic...

(Previous names: acromesomelic dysplasia, Maroteaux type)
(Previous symbols: ANPRB, NPRB, AMDM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Natriuretic Peptide Receptor B/Guanylate Cyclase B (Atrionatriuretic
Peptide Receptor B)1 2
     NPR-B2 3
ANPRB1 2 3 5     EC 4.6.1.23 8
AMDM1 2 5     Acromesomelic Dysplasia, Maroteaux Type1
NPRB1 2     ANPb2
Atrial Natriuretic Peptide Receptor Type B2 3     GUC2B2
Guanylate Cyclase B2 3     GUCY2B2
ANP-B2 3     NPRBi2
ANPR-B2 3     Atrial Natriuretic Peptide B-Type Receptor2
GC-B2 3     Atrial Natriuretic Peptide Receptor 22

External Ids:    HGNC: 79441   Entrez Gene: 48822   Ensembl: ENSG000001598997   OMIM: 1089615   UniProtKB: P205943   

Export aliases for NPR2 gene to outside databases

Previous GC identifers: GC09P036104 GC09P035961 GC09P035782 GC09P035748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPR2 Gene:
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides.
Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single
membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved
in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary
receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl
cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NPR2 Gene: 
NPR2 (natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)) is a protein-coding gene. Diseases associated with NPR2 include acromesomelic dysplasia, and acromesomelic dysplasia, maroteaux type, and among its related super-pathways are G-Beta Gamma Signaling and Cellular Effects of Sildenafil. GO annotations related to this gene include GTP binding and receptor activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ANPRB_HUMAN, P20594
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon
binding of its ligand. May play a role in the regulation of skeletal growth

summary for NPR2 Gene:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPR2 gene promoter:
         AhR   NF-1/L   NF-1   MAZR   GATA-3   Bach2   Arnt   COMP1   SEF-1 (1)   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21-p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p21-p12

NPR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPR2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035792:  view genomic region     (about GC identifiers)

Start:
35,792,151 bp from pter      End:
35,809,729 bp from pter
Size:
17,579 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANPRB_HUMAN, P20594 (See protein sequence)
Recommended Name: Atrial natriuretic peptide receptor 2 precursor  
Size: 1047 amino acids; 117022 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B0ZBF2 B0ZBF3 D3DRP3 D3DRP4 O60871 Q4VAK7 Q5TCV2 Q8TA93 Q9UQ50
Alternative splicing: 2 isoforms:  P20594-1   P20594-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NPR2: NX_P20594

Explore proteomics data for NPR2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of the protein kinase-like domain is required for full activation by CNP (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20594

  • 4/27 DME Specific Peptides for NPR2 (P20594) (see all 27)
     QLRLRIG  TAHGKYQ  LLNDLYT  FIGACID 

    NPR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPR2 Protein Expression
    REFSEQ proteins: NP_003986.2  
    ENSEMBL proteins: 
     ENSP00000341083   ENSP00000399204   ENSP00000393029   ENSP00000402902  

    Human Recombinant Protein Products for NPR2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NPR2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPR2
    GenScript Custom Purified and Recombinant Proteins Services for NPR2
    Novus Biologicals NPR2 Proteins
    Novus Biologicals NPR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPR2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    NPR2 for ontologies           About GeneDecksing



    NPR2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NPR2
    GenScript Custom Superior Antibodies Services for NPR2
    Novus Biologicals NPR2 Antibodies
    Abcam antibodies for NPR2
    Cloud-Clone Corp. Antibodies for NPR2 
    ThermoFisher Antibodies for NPR2
    LSBio Antibodies in human, mouse, rat for NPR2 

    Assay Products for NPR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPR2 
    Cloud-Clone Corp. CLIAs for NPR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NPR-B 
    Natriuretic peptide receptor family

    5/7 InterPro protein domains (see all 7):
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001170 Ntpep_rcpt
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P20594

    ProtoNet protein and cluster: P20594

    2 Blocks protein domains:
    IPB001170 Natriuretic peptide receptor
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: ANPRB_HUMAN, P20594
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    NPR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANPRB_HUMAN, P20594
    Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon
    binding of its ligand. May play a role in the regulation of skeletal growth
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate

         Genatlas biochemistry entry for NPR2:
    natriuretic peptide,receptor B,strongly expressed in the brain,including the pituitary gland and potentially
    playing a role in neuroendocrine regulation

         Enzyme Number (IUBMB): EC 4.6.1.21 2

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IDA1672777
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004872receptor activity TAS10082481
    GO:0004888transmembrane signaling receptor activity TAS1327579
         
    NPR2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NPR2:
     Decreased Salmonella enterica   Decreased substrate adherent c  Increased cell death in DLD-1   Synthetic lethal with Ras 

         15/17 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Npr2) (see all 17):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  muscle  nervous system  no phenotypic analysis  reproductive system 

    NPR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Npr2tm1Gar for NPR2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPR2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR2:
    hsa-miR-558 hsa-miR-3145-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidNPR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPR2
    Sirion Biotech Customized adenovirus for overexpression of NPR2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NPR2 (see all 7)
    OriGene ORF clones in mouse, rat for NPR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPR2 (NM_003995)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR2
    Sirion Biotech Customized lentivirus for stable overexpression of NPR2 
                         Customized lentivirus expression plasmids for stable overexpression of NPR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPR2
    Search LifeMap BioReagents cell lines for NPR2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPR2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-Beta Gamma Signaling
    CRHR Pathway0.44
    Relaxin Pathway0.37
    2Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    3CREB Pathway
    Intracellular Calcium Signaling0.50
    4Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    5Purine metabolism
    Purine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NPR2 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway


    2         Kegg Pathways  (Kegg details for NPR2):
        Purine metabolism
    Vascular smooth muscle contraction


    NPR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for NPR2 (P205943 ENSP000003410834) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPPCP235823, ENSP000002954404I2D: score=2 STRING: ENSP00000295440
    NPPAP011603, ENSP000003656634I2D: score=1 STRING: ENSP00000365663
    NPPBP168603, ENSP000003656514I2D: score=1 STRING: ENSP00000365651
    PDE11AENSP000002860634STRING: ENSP00000286063
    PDE1AENSP000003315744STRING: ENSP00000331574
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006182cGMP biosynthetic process IDA1672777
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction NAS10082481
    GO:0007166cell surface receptor signaling pathway TAS1327579

    NPR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPR2 for compounds           About GeneDecksing

    EMD Millipore small molecules for NPR2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Brain natriuretic peptide (1-32) (human)Endogenous peptide agonist at ANP receptor A (NPR1)[124584-08-3]
    C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2[127869-51-6]
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]
    Atrial natriuretic factor (1-28) (rat)Endogenous peptide regulating blood pressure[88898-17-3]

    5 HMDB Compounds for NPR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for NPR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Erythrityl Tetranitrate1,2,3,4-Butanetetralyl tetranitrate (see all 13)7297-25-8targetagonist19406636 17139284 17016423
    NesiritideBNP (see all 3)124584-08-3target----

    4 IUPHAR Ligands for NPR2 (NPR-B)    About this table 
    LigandTypeActionAffinityPubmed IDs
    C-type natriuretic peptide
    AgonistAgonist1309330
    [Ser11](N-CNP,C-ANP)pBNP2-15
    AntagonistAntagonist15652659
    [125I]CNP (human)
    NoneNone--
    monoclonal antibody 3G12
    AntagonistAntagonist7876238

    10/12 Novoseek inferred chemical compound relationships for NPR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 79.3 35 14691198 (3), 15371450 (2), 8613249 (1), 9950772 (1) (see all 20)
    guanylate 62.7 12 18472099 (1), 9361777 (1), 18664174 (1), 8660352 (1) (see all 10)
    ionomycin 16.4 4 16005434 (3), 12196532 (1)
    sodium nitroprusside 15.7 1 9375582 (1)
    forskolin 14.2 2 15149737 (1)
    calcium 0.329 10 16005434 (3), 15371450 (2), 12196532 (1)
    serine 0.269 2 9485390 (1), 10915802 (1)
    atp 0 2 17848634 (1), 15911610 (1)
    nitric oxide 0 1 9361777 (1)
    threonine 0 1 9485390 (1)

    Search CenterWatch for drugs/clinical trials and news about NPR2 / ANPRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPR2 gene (2 alternative transcripts): 
    NM_003995.3  NM_000907.2  

    Unigene Cluster for NPR2:

    Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
    Hs.78518  [show with all ESTs]
    Unigene Representative Sequence: L13436
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342694(uc003zyd.3) ENST00000464810(uc010mlb.3) ENST00000421267
    ENST00000447210 ENST00000448821 ENST00000469249
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR2:
    hsa-miR-558 hsa-miR-3145-3p hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidNPR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR2
    Clone
    Products:
         
    OriGene clones in human, mouse for NPR2 (see all 7)
    OriGene ORF clones in mouse, rat for NPR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPR2 (NM_003995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR2
    Sirion Biotech Customized lentivirus for stable overexpression of NPR2 
                         Customized lentivirus expression plasmids for stable overexpression of NPR2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NPR2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPR2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR2

    Additional mRNA sequence: 

    BC023017.1 L13436.1 

    7 DOTS entries:

    DT.215817  DT.100022874  DT.100659387  DT.100816353  DT.100816355  DT.92426519  DT.100022873 

    24/126 AceView cDNA sequences (see all 126):

    BM725486 BQ446138 AI090222 F04038 BQ015978 BQ186623 F10387 AW172859 
    BQ184647 BU957197 CD513723 BM719471 W68165 CA423152 BF112084 AA314498 
    AI274470 AJ005282 BC023017 BI754833 CA424770 R54901 BM718802 NM_003995 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NPR2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                                                                      
    SP2:                                                                                            -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NPR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPR2 expression in normal human tissues (normalized intensities)      NPR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCACACA
    NPR2 Expression
    About this image


    NPR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             ganglion/cranial   
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Zeugopod Long Bone
             skeleton/cranium/chondrocranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Autopod
             limb/hindlimb   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             heart/atrium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   

    See NPR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPR2

    SOURCE GeneReport for Unigene cluster: Hs.78518
        SABiosciences Expression via Pathway-Focused PCR Array including NPR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NPR2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPR2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NPR2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npr21 , 5 natriuretic peptide receptor 21, 5 92.23(n)1
    98.66(a)1
      4 (23.05 cM)5
    2301031  NM_173788.31  NP_776149.11 
     436319355 
    chicken
    (Gallus gallus)
    Aves LOC1008593391 atrial natriuretic peptide receptor 2-like 74.24(n)
    80.65(a)
      100859339  XM_003642919.1  XP_003642967.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPR26
    --
    Uncharacterized protein
    80(a)
    57(a)
    1 ↔ 1
    possible ortholog
    GL344709.1(991-23105)
    AAWZ02036748(9649-20246)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9072 Xenopus laevis XGC-2 mRNA for guanylyl cyclase-2, complete more 78.06(n)    AB025112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NPR26
    si:dkey-37g12.16
    si:dkey-37g12.1
    66(a)
    37(a)
    1 ↔ 1
    possible ortholog
    5(62785069-62862175)
    1(42269691-42303114)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107383
    CG311831
    signal transduction receptor guanylate
    cyclase3
    CG311831
    36(a)
    (best of 2)3
    54.3(n)1
    48.04(a)1
      70B13
    419271  NM_142248.21  NP_650505.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T01A4.1b3
    gcy-281
    guanylyl cyclase3
    Protein GCY-281
    57(a)
    (best of 8)3
    51.74(n)1
    48.37(a)1
      I(4502610-4507720)3
    1720511  NM_058978.31  NP_491379.31 


    ENSEMBL Gene Tree for NPR2 (if available)
    TreeFam Gene Tree for NPR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPR2 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  ADCY32  
    7 SIMAP similar genes for NPR2 using alignment to 5 protein entries:     ANPRB_HUMAN (see all proteins):
    NPR1    GUCY1A3    GUCY1B3    GUCY2C    GUCY2F    GUCY2D
    NPRC

    NPR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NPR2
    PGOHUM00000238626


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/478 SNPs in NPR2 are shown (see all 478)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0225904
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225902 Y C mis40--------
    VAR_0225864
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225862 T M mis40--------
    VAR_0225934
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225932 G A mis40--------
    VAR_0225894
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225892 G E mis40--------
    VAR_0225884
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225882 A T mis40--------
    VAR_0225914
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225912 R W mis40--------
    VAR_0225924
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225922 R C mis40--------
    VAR_0225874
    Acromesomelic dysplasia, Maroteaux type (AMDM)4--see VAR_0225872 Y C mis40--------
    rs289315811,2,4
    CAcromesomelic dysplasia, Maroteaux type (AMDM)4 pathogenic135760370(+) TGCTGA/CCAGAA 2 T P mis1 ese30--------
    rs289315821,2,4
    CAcromesomelic dysplasia, Maroteaux type (AMDM)4 pathogenic135760619(+) CCCACG/TGGCGC 2 G W mis1 ese30--------

    HapMap Linkage Disequilibrium report for NPR2 (35792151 - 35809729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NPR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1010658CNV Deletion20482838
    esv2571756CNV Deletion19546169
    esv2900CNV Deletion18987735
    esv2399025CNV Deletion18987734
    esv2738411CNV Deletion23290073
    nsv416447CNV Loss16902084
    dgv8168n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): NPR2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPR2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 108961   
    OMIM disorders: 602875  
    UniProtKB/Swiss-Prot: ANPRB_HUMAN, P20594
  • Acromesomelic dysplasia, Maroteaux type (AMDM) [MIM:602875]: An autosomal recessive acromesomelic
    chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short
    stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal
    to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like
    fingers). AMDM is characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all
    skeletal elements are present but show abnormal rates of linear growth. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/25 diseases for NPR2 (see all 25):    About MalaCards
    acromesomelic dysplasia    acromesomelic dysplasia, maroteaux type    tall stature - scoliosis - macrodactyly of the great toes    renovascular hypertension
    aortic valve stenosis    dwarfism    osteochondrodysplasia    short stature
    essential hypertension    brachydactyly    cerebral infarction    chondrodysplasia
    hypertension    dilated cardiomyopathy    vascular disease    myocardial infarction
    pituitary adenoma    cerebritis    hypoxia    adenoma

    1 disease from the University of Copenhagen DISEASES database for NPR2:
    Osteochondrodysplasia

    NPR2 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for NPR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromesomelic dysplasia, maroteaux type 93.9 4 17652215 (1), 16291870 (1), 16384845 (1), 16716628 (1)
    dwarfism 66 3 16291870 (1), 16716628 (1), 18945719 (1)
    heart failure 36.8 3 11511425 (1), 16291870 (1), 18848850 (1)
    short stature 36 6 16384845 (3), 16716628 (1)
    cardiac hypertrophy 35.9 1 17429599 (1)
    essential hypertension 30.2 3 11464256 (2), 10082481 (1)
    heart failure congestive 25.9 1 8760130 (1)
    cardiovascular diseases 0 1 11464256 (1)
    hypertension pulmonary 0 1 15911074 (1)
    myocardial infarction 0 1 11208455 (1)

    Genetic Association Database (GAD): NPR2
    Human Genome Epidemiology (HuGE) Navigator: NPR2 (8 documents)

    Export disorders for NPR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPR2 gene, integrated from 9 sources (see all 161):
    (articles sorted by number of sources associating them with NPR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension. (PubMed id 10082481)1, 2, 4, 9 Rehemudula D.... Ozawa Y. (1999)
    2. Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. (PubMed id 15146390)1, 2, 3 Bartels C.F....Warman M.L. (2004)
    3. Systematic screening of type B human natriuretic peptide receptor gene polymorphisms and association with essential hypertension. (PubMed id 11464256)1, 4, 9 Rahmutula D....Ozawa Y. (2001)
    4. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)1, 2, 9 Koller K.J....Goeddel D.V. (1991)
    5. A C2077T polymorphism of the type B human natriuretic peptide receptor gene is not associated with myocardial infarction. (PubMed id 11208455)1, 4, 9 Rahmutula D....Ozawa Y. (2000)
    6. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4, 9 Fox A.A....Body S.C. (2009)
    7. Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. (PubMed id 1660465)1, 2, 9 Bennett B.D.... Lowe D.G. (1991)
    8. Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B. (PubMed id 20977274)1, 2 Yoder A.R.... Potter L.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4882 HGNC: 7944 AceView: NPR2 Ensembl:ENSG00000159899 euGenes: HUgn4882
    ECgene: NPR2 Kegg: 4882 H-InvDB: NPR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPR2 gene:
    Search GeneIP for patents involving NPR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for NPR2
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NPR2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NPR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPR2   OriGene Custom Protein Services for NPR2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPR2
     QIAGEN SeqTarget long-range PCR primers for resequencing NPR2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPR2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR2
     GenScript Custom Purified and Recombinant Proteins Services for NPR2 GenScript cDNA clones with any tag delivered in your preferred vector for NPR2
     GenScript Custom Assay Services for NPR2 GenScript Custom Superior Antibodies Services for NPR2
     GenScript Custom overexpressing Cell Line Services for NPR2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NPR2 promoter
     Search Chromatin IP Primers for NPR2
     RT2 qPCR Primer Assay in human, mouse, rat NPR2
     GNC Network for NPR2
     SABiosciences PCR Arrays including human, mouse, rat NPR2
     Tocris compounds for NPR2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPR2 antibodies
     NPR2 proteins
     NPR2 lysates
     Antibodies for NPR2
     See all of Abcam's Antibodies, Kits and Proteins for NPR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NPR2
     Antibodies for NPR2
     ELISAs for NPR2
     CLIAs for NPR2
     Search LifeMap BioReagents cell lines for NPR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR2
     SwitchGear 3'UTR luciferase reporter plasmids for NPR2
     SwitchGear Promoter luciferase reporter plasmids for NPR2
     ThermoFisher Antibodies for NPR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPR2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPR2
    Customized:
     lentivirus for stable overexpression of NPR2
     lentivirus expression plasmids for stable overexpression of NPR2
     adenovirus for overexpression of NPR2
     LSBio Antibodies in human, mouse, rat for NPR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPR2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4