Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NPR1 Gene

Aliases for NPR1 Gene

  • Natriuretic Peptide Receptor 1 2 3
  • Guanylate Cyclase A 2 3 4
  • ANPRA 3 4 6
  • Atrial Natriuretic Peptide Receptor Type A 3 4
  • Atrionatriuretic Peptide Receptor A 2 3
  • Natriuretic Peptide Receptor A 2 3
  • EC 4 63
  • ANPR-A 3 4
  • ANP-A 3 4
  • NPR-A 3 4
  • GC-A 3 4
  • Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) 3
  • Atrial Natriuretic Peptide Receptor 1 3
  • Natriuretic Peptide A Type Receptor 3
  • GUCY2A 3
  • GUC2A 3
  • ANPa 3
  • NPRA 3

External Ids for NPR1 Gene

Previous HGNC Symbols for NPR1 Gene

  • NPRA

Previous GeneCards Identifiers for NPR1 Gene

  • GC01P151499
  • GC01P149382
  • GC01P150426
  • GC01P150867
  • GC01P150465
  • GC01P151917
  • GC01P153651
  • GC01P125014

Summaries for NPR1 Gene

Entrez Gene Summary for NPR1 Gene

  • Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

GeneCards Summary for NPR1 Gene

NPR1 (Natriuretic Peptide Receptor 1) is a Protein Coding gene. Diseases associated with NPR1 include hypertensive heart disease and breast adenocarcinoma. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include GTP binding and protein kinase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for NPR1 Gene

  • Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Tocris Summary for NPR1 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is in homeostasis of body fluid volume.

Gene Wiki entry for NPR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR1 Gene

Genomics for NPR1 Gene

Regulatory Elements for NPR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPR1 Gene

153,678,617 bp from pter
153,693,992 bp from pter
15,376 bases
Plus strand

Genomic View for NPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR1 Gene

Proteins for NPR1 Gene

  • Protein details for NPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Atrial natriuretic peptide receptor 1
    Protein Accession:
    Secondary Accessions:
    • B0ZBF0
    • Q5SR08
    • Q6P4Q3

    Protein attributes for NPR1 Gene

    1061 amino acids
    Molecular mass:
    118919 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for NPR1 Gene

Proteomics data for NPR1 Gene at MOPED

Post-translational modifications for NPR1 Gene

  • Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
  • Glycosylation at Asn34, Asn45, Asn212, Asn338, Asn379, Asn386, and Asn427
  • Modification sites at PhosphoSitePlus

Other Protein References for NPR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for NPR1 Gene

Gene Families for NPR1 Gene

Suggested Antigen Peptide Sequences for NPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P16066
  • Contains 1 guanylate cyclase domain.
  • Contains 1 protein kinase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with NPR1: view

Function for NPR1 Gene

Molecular function for NPR1 Gene

GENATLAS Biochemistry: natriuretic peptide,receptor A,expressed in kidney,vascular endothelium and adrenal glands,responding to ANP (NPPA) and to a lesser degree to BNP by mediating vasorelaxant and natriuretic functions and decreasing aldosterone synthesis
UniProtKB/Swiss-Prot CatalyticActivity: GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Enzyme Numbers (IUBMB) for NPR1 Gene

Gene Ontology (GO) - Molecular Function for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004383 guanylate cyclase activity IDA 1672777
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NPR1: view
genes like me logo Genes that share phenotypes with NPR1: view

Animal Models for NPR1 Gene

MGI Knock Outs for NPR1:

Animal Model Products

CRISPR Products

miRNA for NPR1 Gene

miRTarBase miRNAs that target NPR1

No data available for Transcription Factor Targeting and HOMER Transcription for NPR1 Gene

Localization for NPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NPR1 Gene COMPARTMENTS Subcellular localization image for NPR1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IC 12547834
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with NPR1: view

Pathways for NPR1 Gene

genes like me logo Genes that share pathways with NPR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0006468 protein phosphorylation IEA --
GO:0007166 cell surface receptor signaling pathway NAS 12547834
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007186 G-protein coupled receptor signaling pathway NAS 12547834
genes like me logo Genes that share ontologies with NPR1: view

Compounds for NPR1 Gene

(4) Tocris Compounds for NPR1 Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure [91917-63-4]
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 [127869-51-6]
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure [88898-17-3]
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) [124584-08-3]

(5) HMDB Compounds for NPR1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-cyclic GMP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion

(6) Drugbank Compounds for NPR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amyl Nitrite
  • Amyl nitrosum
110-46-3 target agonist
Erythrityl Tetranitrate
  • 1,2,3,4-Butanetetralyl tetranitrate
7297-25-8 target agonist
Isosorbide Dinitrate
  • Dianhydrosorbitol 2,5-dinitrate
87-33-2 target agonist
  • BNP
124584-08-3 target binder
  • Glyceryl trinitrate
55-63-0 target agonist

(7) IUPHAR Ligand for NPR1 Gene

Ligand Type Action Affinity Pubmed IDs
A-71915 Antagonist Antagonist 9.5
[Asu7,23]beta-ANP-(7-28) Antagonist Antagonist 7.5
atrial natriuretic peptide Agonist Agonist
[125I]ANP None None
anantin Antagonist Antagonist
sANP Agonist Agonist
brain natriuretic peptide Agonist Agonist

(23) Novoseek inferred chemical compound relationships for NPR1 Gene

Compound -log(P) Hits PubMed IDs
anantin 86.2 3
cgmp 81.1 47
urodilatin 80.5 3
guanylate 67.1 16
8-bromo cgmp 61.9 1
genes like me logo Genes that share compounds with NPR1: view

Transcripts for NPR1 Gene

Unigene Clusters for NPR1 Gene

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for NPR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPR1 Gene

mRNA expression in normal human tissues for NPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR1 Gene

This gene is overexpressed in Artery - Aorta (9.6) and Adipose - Visceral (Omentum) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPR1 Gene

SOURCE GeneReport for Unigene cluster for NPR1 Gene Hs.490330

genes like me logo Genes that share expressions with NPR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NPR1 Gene

Orthologs for NPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPR1 35
  • 98.71 (n)
  • 98.49 (a)
NPR1 36
  • 99 (a)
(Bos Taurus)
Mammalia NPR1 35
  • 91.05 (n)
  • 93.38 (a)
NPR1 36
  • 93 (a)
(Canis familiaris)
Mammalia NPR1 35
  • 90.03 (n)
  • 92.84 (a)
NPR1 36
  • 92 (a)
(Mus musculus)
Mammalia Npr1 35
  • 87.04 (n)
  • 91.66 (a)
Npr1 16
Npr1 36
  • 91 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia NPR1 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Npr1 35
  • 87.54 (n)
  • 91.48 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia NPR1 36
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68769 35
(Danio rerio)
Actinopterygii NPR1 (1 of 2) 36
  • 62 (a)
npr1a 35
  • 66.01 (n)
  • 64.32 (a)
npr1a 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008691 35
  • 54.47 (n)
  • 46.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31183 36
  • 32 (a)
CG3216 35
  • 54.41 (n)
  • 45.39 (a)
CG14886 37
  • 38 (a)
Gyc76C 37
  • 35 (a)
CG3216 37
  • 39 (a)
CG5719 37
  • 56 (a)
Gyc32E 37
  • 35 (a)
CG10738 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea gcy-28 36
  • 36 (a)
gcy-19 37
  • 30 (a)
gcy-31 37
  • 40 (a)
T01A4.1a 37
  • 54 (a)
gcy-11 37
  • 36 (a)
gcy-21 37
  • 46 (a)
gcy-13 37
  • 30 (a)
gcy-4 37
  • 29 (a)
gcy-7 37
  • 34 (a)
T01A4.1b 37
  • 58 (a)
gcy-3 37
  • 30 (a)
gcy-20 37
  • 32 (a)
daf-11 37
  • 30 (a)
gcy-23 37
  • 29 (a)
gcy-6 37
  • 31 (a)
gcy-27 37
  • 32 (a)
odr-1 37
  • 32 (a)
gcy-9 37
  • 30 (a)
gcy-2 37
  • 30 (a)
gcy-15 37
  • 45 (a)
gcy-5 37
  • 31 (a)
gcy-22 37
  • 31 (a)
gcy-8 37
  • 28 (a)
gcy-12 37
  • 32 (a)
gcy-14 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
-- 36
  • 46 (a)
Species with no ortholog for NPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NPR1 Gene

Gene Tree for NPR1 (if available)
Gene Tree for NPR1 (if available)

Paralogs for NPR1 Gene

Selected SIMAP similar genes for NPR1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NPR1: view

Variants for NPR1 Gene

Sequence variations from dbSNP and Humsavar for NPR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2228581 -- 153,686,741(+) CGTGG(A/G)AGCCT synonymous-codon, reference
rs2229835 -- 153,688,210(+) TTGCG(C/T)AAATT reference, synonymous-codon
rs3891075 -- 153,685,711(+) AAGGC(A/T)GGATA intron-variant
rs4083382 -- 153,680,160(+) ctcAT(G/T)GCGCC intron-variant
rs5777877 -- 153,685,672(+) ATCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPR1 Gene

Variant ID Type Subtype PubMed ID
nsv464028 CNV Gain 19166990

Relevant External Links for NPR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPR1 Gene

Disorders for NPR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for NPR1 Gene including...

Search for NPR1 Gene in MalaCards »

(18) Novoseek inferred disease relationships for NPR1 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 52.3 6
essential hypertension 47.2 4
heart failure congestive 44.5 2
heart failure 38.9 3
hypertensive heart disease 34.7 2

Relevant External Links for NPR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NPR1: view

No data available for UniProtKB/Swiss-Prot for NPR1 Gene

Publications for NPR1 Gene

  1. Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina. (PMID: 7954658) Pardhasaradhi K. … Krishna G. (Cell. Mol. Neurobiol. 1994) 3 4 23
  2. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PMID: 1672777) Koller K.J. … Goeddel D.V. (Science 1991) 3 4 23
  3. Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family. (PMID: 1979052) Lowe D.G. … Goeddel D.V. (Genomics 1990) 2 3 23
  4. Organization of the human natriuretic peptide receptor A gene. (PMID: 9618281) Takahashi Y. … Kanmatsuse K. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  5. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PMID: 12872042) Pitzalis M.V. … Rizzon P. (J. Hypertens. 2003) 3 23 48

Products for NPR1 Gene

Sources for NPR1 Gene

Back to Top