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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPR1 Gene

protein-coding   GIFtS: 68
GCID: GC01P153651

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic...


(Previous symbols: ANPRA, NPRA)
 Explore 38 diseases affiliated with
NPR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPR1    

Aliases
for NPR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic Peptide
Receptor A)1 2
     GC-A2 3
ANPRA1 2 3 5     NPR-A2 3
ANPa1 2     EC 4.6.1.23 8
GUCY2A1 2     GUC2A2
NPRA1 2     Atrial Natriuretic Peptide Receptor 12
Atrial Natriuretic Peptide Receptor Type A2 3     Atrionatriuretic Peptide Receptor A2
Guanylate Cyclase A2 3     Natriuretic Peptide A Type Receptor2
ANP-A2 3     Natriuretic Peptide Receptor A2
ANPR-A2 3     

External Ids:    HGNC: 79431   Entrez Gene: 48812   Ensembl: ENSG000001694187   OMIM: 1089605   UniProtKB: P160663   

Export aliases for NPR1 gene to outside databases

Previous GC identifers: GC01P151499 GC01P149382 GC01P150426 GC01P150867 GC01P150465 GC01P151917 GC01P125014


Summaries
for NPR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NPR1:
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers
and Lowe, 1994 (PubMed 7982997)). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a
family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a
single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase
catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial
natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a
protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound
guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP
(MIM 600295), respectively).(supplied by OMIM, May 2009)

UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066
Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are
potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon
binding of the ligand

summary for NPR1:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPR1


Genomic Views
for NPR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPR1 gene promoter:
         E2F   E2F-1   Sp1   Nkx2-5   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21-q22

NPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153651:  view genomic region     (about GC identifiers)

Start:
 153,651,113 bp from pter      End:
 153,666,468 bp from pter
Size:
 15,356 bases      Orientation:
 plus strand

Proteins
for NPR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066 (See protein sequence)
Recommended Name: Atrial natriuretic peptide receptor 1 precursor  
Size: 1061 amino acids; 118919 Da
Subunit: Homodimer (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B0ZBF0 Q5SR08 Q6P4Q3

Explore the universe of human proteins at neXtProt for NPR1: NX_P16066

Post-translational modifications:

  • Phosphorylation of the protein kinase-like domain is required for full activation by ANP (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16066

    • 4/16 DME Specific Peptides for NPR1 (P16066) (see all 16)
     QLRLRIG  NDIVKGM  LLNDLYT  FSDIVGFT 

    NPR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000897.3  
    ENSEMBL proteins: 
     ENSP00000357669   ENSP00000357666  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: NPR1
    OriGene Protein Over-expression Lysate: NPR1
    OriGene Custom Protein Services for NPR1 
    GenScript Custom Purified and Recombinant Proteins Services for NPR1
    Novus Biologicals NPR1 Protein
    Novus Biologicals NPR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPR1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IC12547834


    NPR1 for ontologies           About GeneDecksing



    NPR1 Antibody Products: 
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    Novus Biologicals NPR1 Antibodies
    Search for Antibodies for NPR1 at Abcam  
    Uscn Antibodies for NPR1
    ThermoFisher Antibodies for NPR1

    Assay Products for NPR1: 
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    Browse OriGene Fluorogenic Cell Assay Kits
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NPR1

    Protein Domains /
    Families
    for NPR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPR1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P16066

    ProtoNet protein and cluster: P16066

    2 Blocks protein families:
    IPB001170 Natriuretic peptide receptor
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    Function
    for NPR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066
    Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are
    potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon
    binding of the ligand
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate

         Genatlas biochemistry entry for NPR1:
    natriuretic peptide,receptor A,expressed in kidney,vascular endothelium and adrenal glands,responding to ANP (NPPA) and
    to a lesser degree to BNP by mediating vasorelaxant and natriuretic functions and decreasing aldosterone synthesis

    Enzyme Number (IUBMB): EC 4.6.1.21 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NPR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR1:
    hsa-miR-767-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: NPR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPR1 (see all 7)
    OriGene shRNA RFP: NPR1
    OriGene siRNA: NPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPR1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NPR1 (NM_000906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NPR1
    Search LifeMap BioReagents cell lines for NPR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR1

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004383guanylate cyclase activity IDA1672777
    GO:0004672protein kinase activity IEA--
    GO:0004872receptor activity ----
    GO:0005515protein binding ----


    NPR1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NPR1:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for NPR1: Npr1tm1Mae Npr1tm1Gar
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Npr1):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  muscle  reproductive system  respiratory system 

    NPR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-Beta Gamma Signaling
    		CRHR Pathway0.44
    		Relaxin Pathway0.32
    2Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36
    3Visual Cycle in Retinal Rods
    		Visual Cycle in Retinal Rods1.00
    4Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    5Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NPR1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway


    2         Kegg Pathways  (Kegg details for NPR1):
        Purine metabolism
    Vascular smooth muscle contraction


    NPR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for NPR1 (P160662, 3 ENSP000003576694) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61913 I2D: score=3 
    PRKG1Q139763, ENSP000003630924I2D: score=2 STRING: ENSP00000363092
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NPPAP011603, ENSP000003656634I2D: score=1 STRING: ENSP00000365663
    NPPBP168603, ENSP000003656514I2D: score=1 STRING: ENSP00000365651
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process IDA1672777
    GO:0007166cell surface receptor signaling pathway NAS12547834
    GO:0007168receptor guanylyl cyclase signaling pathway IDA1672777
    GO:0007589body fluid secretion TAS14960748
    GO:0008217regulation of blood pressure NAS12727915


    NPR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPR1 for compounds           About GeneDecksing

    EMD Millipore small molecules for NPR1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Brain natriuretic peptide (1-32) (human)Endogenous peptide agonist at ANP receptor A (NRP1)[124584-08-3]
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]

    5 HMDB Compounds for NPR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    6 DrugBank Compounds for NPR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Isosorbide DinitrateDianhydrosorbitol 2,5-dinitrate (see all 4)87-33-2targetagonist17139284 16007231 12419094 15465035 17016423
    Erythrityl Tetranitrate1,2,3,4-Butanetetralyl tetranitrate (see all 13)7297-25-8targetagonist2895614 17139284 17016423
    NitroprussideDisodium nitroprusside dihydrate (see all 4)15078-28-1targetagonist16902599 17016498 15093694
    Amyl NitriteAmyl nitrosum (see all 6)110-46-3targetagonist19732062 12890708
    NitroglycerinGlyceryl trinitrate (see all 7)55-63-0targetagonist19732062 12890708
    NesiritideBNP (see all 3)124584-08-3targetbinder11752352

    10/23 Novoseek chemical compound relationships for NPR1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anantin 86.2 3 18223163 (2), 14583135 (1)
    cgmp 81.1 63 16902599 (6), 10537139 (3), 20097258 (3), 8613249 (2) (see all 34)
    urodilatin 80.5 4 9512977 (1), 9689013 (1), 20206222 (1)
    guanylate 67.1 19 7954658 (2), 18472099 (1), 19165164 (1), 19679847 (1) (see all 15)
    8-bromo cgmp 61.9 2 9689013 (1)
    disuccinimidyl suberate 51.9 2 1358197 (1), 1356991 (1)
    jasmonic acid 44.8 5 19716624 (2), 16415067 (1)
    amp-pnp 43 2 17848634 (1)
    sodium 25.8 3 9512977 (1), 12824076 (1), 20206222 (1)
    atp 20.6 8 16262696 (1), 9528788 (1), 17848634 (1), 8102767 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about NPR1 / ANPRA 

    Transcripts
    for NPR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPR1 gene: 
    NM_000906.3  

    Unigene Cluster for NPR1:

    Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
    Hs.490330  [show with all ESTs]
    Unigene Representative Sequence: BC063304
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368680(uc001fcs.4 uc010pdz.2 uc010pea.2) ENST00000368677


    miRNA
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    hsa-miR-767-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmid: NPR1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: NPR1
    OriGene siRNA: NPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR1
    Clone
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    GenScript: all cDNA clones in your preferred vector: NPR1 (NM_000906)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR1

    Additional cDNA sequence: 

    AK025024.1 AK298090.1 AK300446.1 BC063304.1 S72628.1 X15357.1 

    4 DOTS entries:

    DT.209401  DT.102840747  DT.95172149  DT.91710927 

    24/112 AceView cDNA sequences (see all 112):

    BE746385 BQ896594 AI889834 BQ888212 S72628 BE741410 BQ016270 BQ681250 
    AI567201 R46749 AI884554 AI984876 BQ017282 BQ721030 R46756 T28476 
    AK025024 AI190837 AA978089 AI676183 BU728059 R46850 AI367636 CD110228 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NPR1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -           -           -                                                               
    SP4:                    -           -                                                               
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for NPR1

    Expression
    for NPR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCAGAGACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    KidneyRenal Collecting Duct SystemCollecting Duct CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NPR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPR1

    SOURCE GeneReport for Unigene cluster: Hs.490330
        SABiosciences Expression via Pathway-Focused PCR Arrays including NPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Osmotic Stress in human mouse rat

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    Orthologs
    for NPR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NPR1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NPR16
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL344609.1(17639-23544)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687692 hypothetical protein MGC68769 77.56(n)    BC063739.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii npr1a1 natriuretic peptide receptor 1a 66.14(n)
    64.5(a)    		   560653  NM_001044937.2  NP_001038402.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG57193
    CG32161    		 guanylate cyclase3
    CG32161    		 56(a)
    (best of 6)3
    54.41(n)1
    45.39(a)1    		   55B123
    373761  NM_166415.21  NP_726013.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea T01A4.1b3 guanylyl cyclase 58(a)
    (best of 24)    		   I(4502610-4507720)   --


    ENSEMBL Gene Tree for NPR1 (if available)
    TreeFam Gene Tree for NPR1 (if available) 

    Paralogs
    for NPR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPR1 gene
    ADCY52  ADCY22  ADCY92  GUCY2D2  GUCY1B32  ADCY62  GUCY2C2  GUCY1A32  
    ADCY12  ADCY42  GUCY2F2  ADCY82  GUCY1A22  NPR22  ADCY72  ADCY32  
    15 SIMAP similar genes for NPR1 using alignment to 3 protein entries:     ANPRA_HUMAN (see all proteins):
    NPR2    ADCY4    GUCY1A2    GUCY1B3    GUCY1A3    GUCY2C
    ADCY8    ADCY5    ADCY1    ADCY2    ADCY3    NPRC
    ADCY7    GUCY2D    GUCY2F

    NPR1 for paralogs           About GeneDecksing



    Genomic Variants
    for NPR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/369 NCBI SNPs in NPR1 are shown (see all 369)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1504131751,2
    		--153649367(+) GTTATC/TCAGGA 1 -- us2k10--------
    rs1909965671,2
    		--153649400(+) GGATCA/GCTTGA 1 -- us2k10--------
    rs120623021,2
    		--153649430(+) gcctgA/Ggcaac 1 -- us2k10--------
    rs1868057121,2
    		--153649529(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1382131771,2
    		--153649632(+) CCCAAA/GTAGCT 1 -- us2k10--------
    rs617572811,2
    		C,--153649650(+) CAGGCG/TGCCGC 1 -- us2k11Minor allele frequency- T:0.00NS 556
    rs617572821,2
    		C,F,--153649747(+) ATCCAC/TCCACC 1 -- us2k11Minor allele frequency- T:0.01NS 556
    rs1432621451,2
    		C,--153649791(+) AGCCA-/CCTTGC 1 -- us2k10--------
    rs1923873561,2
    		--153649924(+) AAGAAC/TATTCA 1 -- us2k10--------
    rs748283221,2
    		F,--153649959(+) GAAATG/ATACTT 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for NPR1 (153651113 - 153666468 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPR1: --
    Human Gene Mutation Database (HGMD): NPR1

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    Disorders / Diseases
    for NPR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPR1 for disorders           About GeneDecksing

    OMIM gene information: 108960    OMIM disorders: --

    20/38 diseases for NPR1 (see all 38):    About MalaCards
    cone-rod dystrophy    leber congenital amaurosis    aortic valve stenosis    hypertensive heart disease
    irritable bowel syndrome    essential hypertension    myocardial infarction    atrial fibrillation
    priapism    glaucoma    colon adenocarcinoma    cystic kidney
    hypertension    constipation    gigantism    adenocarcinoma
    kidney disease    diarrhea    ischemia    aldosteronism

    1 disease from the University of Copenhagen DISEASES database for NPR1:
    Acromesomelic dysplasia

    10/18 Novoseek disease relationships for NPR1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 52.3 10 10537139 (1), 15710627 (1), 9405681 (1), 12483301 (1) (see all 6)
    essential hypertension 47.2 5 10785505 (1), 16875975 (1), 10604494 (1), 12483301 (1)
    heart failure congestive 44.5 4 15710627 (1), 8760130 (1)
    heart failure 38.9 4 20171990 (1), 11511425 (1), 16778132 (1)
    hypertensive heart disease 34.7 3 9405681 (1), 12824076 (1)
    ventricular hypertrophy 23.6 2 10785505 (1), 12891290 (1)
    colon adenocarcinoma 18.5 1 16648657 (1)
    somatic mutations 4.9 3 14519099 (2)
    tumors 0.873 2 15710627 (1), 10529624 (1)
    glaucoma 0 4 17460430 (3)

    Genetic Association Database (GAD): NPR1
    Human Genome Epidemiology (HuGE) Navigator: NPR1 (17 documents)

    Export disorders for NPR1 gene to outside databases

    Publications
    for NPR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPR1 gene, integrated from 9 sources (see all 233):
    (articles sorted by number of sources associating them with NPR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina. (PubMed id 7954658)1, 2, 9 Pardhasaradhi K.... Krishna G. (1994)
    2. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PubMed id 12872042)1, 4, 9 Pitzalis M.V....Rizzon P. (2003)
    3. Missense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarction. (PubMed id 14646971)1, 4, 9 Nakayama T....Kokubun S. (2003)
    4. Organization of the human natriuretic peptide receptor A gene. (PubMed id 9618281)1, 2, 9 Takahashi Y.... Kanmatsuse K. (1998)
    5. Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family. (PubMed id 1979052)1, 3, 9 Lowe D.G....Goeddel D.V. (1990)
    6. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)1, 2, 9 Koller K.J....Goeddel D.V. (1991)
    7. Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. (PubMed id 1660465)1, 2, 9 Bennett B.D.... Lowe D.G. (1991)
    8. Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B. (PubMed id 20977274)1, 2 Yoder A.R.... Potter L.R. (2010)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for NPR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4881 HGNC: 7943 AceView: NPR1 Ensembl:ENSG00000169418 euGenes: HUgn4881
    ECgene: NPR1 Kegg: 4881 H-InvDB: NPR1

    Other Databases showing NPR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPR1 gene:
    Search GeneIP for patents involving NPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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