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Aliases for NPR1 Gene

Aliases for NPR1 Gene

  • Natriuretic Peptide Receptor 1 2 3
  • Guanylate Cyclase A 2 3 4
  • ANPRA 3 4 6
  • Atrial Natriuretic Peptide Receptor Type A 3 4
  • Atrionatriuretic Peptide Receptor A 2 3
  • Natriuretic Peptide Receptor A 2 3
  • EC 4.6.1.2 4 64
  • ANPR-A 3 4
  • ANP-A 3 4
  • NPR-A 3 4
  • GC-A 3 4
  • Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) 3
  • Atrial Natriuretic Peptide Receptor 1 3
  • Natriuretic Peptide A Type Receptor 3
  • GUCY2A 3
  • GUC2A 3
  • ANPa 3
  • NPRA 3

External Ids for NPR1 Gene

Previous Symbols for NPR1 Gene

  • ANPRA
  • NPRA

Summaries for NPR1 Gene

Entrez Gene Summary for NPR1 Gene

  • Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

GeneCards Summary for NPR1 Gene

NPR1 (Natriuretic Peptide Receptor 1) is a Protein Coding gene. Diseases associated with NPR1 include hypertensive heart disease and breast adenocarcinoma. Among its related pathways are CREB Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include GTP binding and protein kinase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for NPR1 Gene

  • Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Tocris Summary for NPR1 Gene

  • Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is in homeostasis of body fluid volume.

Gene Wiki entry for NPR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPR1 Gene

Genomics for NPR1 Gene

Genomic Location for NPR1 Gene

Start:
153,678,617 bp from pter
End:
153,693,992 bp from pter
Size:
15,376 bases
Orientation:
Plus strand

Genomic View for NPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPR1 Gene

Regulatory Elements for NPR1 Gene

Proteins for NPR1 Gene

  • Protein details for NPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16066-ANPRA_HUMAN
    Recommended name:
    Atrial natriuretic peptide receptor 1
    Protein Accession:
    P16066
    Secondary Accessions:
    • B0ZBF0
    • Q5SR08
    • Q6P4Q3

    Protein attributes for NPR1 Gene

    Size:
    1061 amino acids
    Molecular mass:
    118919 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for NPR1 Gene

Proteomics data for NPR1 Gene at MOPED

Post-translational modifications for NPR1 Gene

  • Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn34, Asn45, Asn212, Asn338, Asn379, Asn386, and Asn427

Other Protein References for NPR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for NPR1 Gene

Gene Families for NPR1 Gene

UniProtKB/Swiss-Prot:

ANPRA_HUMAN
Domain:
  • Contains 1 guanylate cyclase domain.:
    • P16066
  • Contains 1 protein kinase domain.:
    • P16066
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • P16066
genes like me logo Genes that share domains with NPR1: view

Function for NPR1 Gene

Molecular function for NPR1 Gene

GENATLAS Biochemistry: natriuretic peptide,receptor A,expressed in kidney,vascular endothelium and adrenal glands,responding to ANP (NPPA) and to a lesser degree to BNP by mediating vasorelaxant and natriuretic functions and decreasing aldosterone synthesis
UniProtKB/Swiss-Prot CatalyticActivity: GTP = 3,5-cyclic GMP + diphosphate
UniProtKB/Swiss-Prot Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Enzyme Numbers (IUBMB) for NPR1 Gene

Gene Ontology (GO) - Molecular Function for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004383 guanylate cyclase activity IDA 1672777
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NPR1: view
genes like me logo Genes that share phenotypes with NPR1: view

Animal Models for NPR1 Gene

MGI Knock Outs for NPR1:

miRNA for NPR1 Gene

miRTarBase miRNAs that target NPR1

No data available for Transcription Factor Targeting and HOMER Transcription for NPR1 Gene

Localization for NPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPR1 Gene COMPARTMENTS Subcellular localization image for NPR1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IC 12547834
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with NPR1: view

Pathways for NPR1 Gene

genes like me logo Genes that share pathways with NPR1: view

Gene Ontology (GO) - Biological Process for NPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0006468 protein phosphorylation IEA --
GO:0007166 cell surface receptor signaling pathway NAS 12547834
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007186 G-protein coupled receptor signaling pathway NAS 12547834
genes like me logo Genes that share ontologies with NPR1: view

Compounds for NPR1 Gene

(4) Tocris Compounds for NPR1 Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure [91917-63-4]
Atrial natriuretic factor (1-28) (rat) Endogenous peptide regulating blood pressure [88898-17-3]
Brain natriuretic peptide (1-32) (human) Endogenous peptide agonist at ANP receptor A (NPR1) [124584-08-3]
C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2 [127869-51-6]

(5) HMDB Compounds for NPR1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(6) Drugbank Compounds for NPR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amyl Nitrite
  • Amyl nitrosum
110-46-3 target agonist
Erythrityl Tetranitrate
  • 1,2,3,4-Butanetetralyl tetranitrate
7297-25-8 target agonist
Isosorbide Dinitrate
  • Dianhydrosorbitol 2,5-dinitrate
87-33-2 target agonist
Nesiritide
  • BNP
124584-08-3 target binder
Nitroglycerin
  • Glyceryl trinitrate
55-63-0 target agonist

(7) IUPHAR Ligand for NPR1 Gene

Ligand Type Action Affinity Pubmed IDs
A-71915 Antagonist Antagonist 9.5
[Asu7,23]beta-ANP-(7-28) Antagonist Antagonist 7.5
atrial natriuretic peptide Agonist Agonist
[125I]ANP None None
anantin Antagonist Antagonist
sANP Agonist Agonist
brain natriuretic peptide Agonist Agonist

(23) Novoseek inferred chemical compound relationships for NPR1 Gene

Compound -log(P) Hits PubMed IDs
anantin 86.2 3
cgmp 81.1 47
urodilatin 80.5 3
guanylate 67.1 16
8-bromo cgmp 61.9 1
genes like me logo Genes that share compounds with NPR1: view

Transcripts for NPR1 Gene

Unigene Clusters for NPR1 Gene

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPR1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for NPR1 Gene

GeneLoc Exon Structure for
NPR1
ECgene alternative splicing isoforms for
NPR1

Expression for NPR1 Gene

mRNA expression in normal human tissues for NPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPR1 Gene

This gene is overexpressed in Artery - Aorta (9.6) and Adipose - Visceral (Omentum) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPR1 Gene

SOURCE GeneReport for Unigene cluster for NPR1 Gene Hs.490330

genes like me logo Genes that share expressions with NPR1: view

Orthologs for NPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPR1 36
  • 98.71 (n)
  • 98.49 (a)
NPR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPR1 36
  • 91.05 (n)
  • 93.38 (a)
NPR1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPR1 36
  • 90.03 (n)
  • 92.84 (a)
NPR1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npr1 36
  • 87.04 (n)
  • 91.66 (a)
Npr1 16
Npr1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NPR1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npr1 36
  • 87.54 (n)
  • 91.48 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NPR1 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68769 36
zebrafish
(Danio rerio)
Actinopterygii NPR1 (1 of 2) 37
  • 62 (a)
OneToMany
npr1a 36
  • 66.01 (n)
  • 64.32 (a)
npr1a 37
  • 62 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008691 36
  • 54.47 (n)
  • 46.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31183 37
  • 32 (a)
OneToMany
CG3216 36
  • 54.41 (n)
  • 45.39 (a)
CG14886 38
  • 38 (a)
Gyc76C 38
  • 35 (a)
CG3216 38
  • 39 (a)
CG5719 38
  • 56 (a)
Gyc32E 38
  • 35 (a)
CG10738 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea gcy-28 37
  • 36 (a)
OneToMany
gcy-19 38
  • 30 (a)
gcy-31 38
  • 40 (a)
T01A4.1a 38
  • 54 (a)
gcy-11 38
  • 36 (a)
gcy-21 38
  • 46 (a)
gcy-13 38
  • 30 (a)
gcy-4 38
  • 29 (a)
gcy-7 38
  • 34 (a)
T01A4.1b 38
  • 58 (a)
gcy-3 38
  • 30 (a)
gcy-20 38
  • 32 (a)
daf-11 38
  • 30 (a)
gcy-23 38
  • 29 (a)
gcy-6 38
  • 31 (a)
gcy-27 38
  • 32 (a)
odr-1 38
  • 32 (a)
gcy-9 38
  • 30 (a)
gcy-2 38
  • 30 (a)
gcy-15 38
  • 45 (a)
gcy-5 38
  • 31 (a)
gcy-22 38
  • 31 (a)
gcy-8 38
  • 28 (a)
gcy-12 38
  • 32 (a)
gcy-14 38
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
Species with no ortholog for NPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NPR1 Gene

ENSEMBL:
Gene Tree for NPR1 (if available)
TreeFam:
Gene Tree for NPR1 (if available)

Paralogs for NPR1 Gene

Selected SIMAP similar genes for NPR1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NPR1: view

Variants for NPR1 Gene

Sequence variations from dbSNP and Humsavar for NPR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2228581 -- 153,686,741(+) CGTGG(A/G)AGCCT synonymous-codon, reference
rs2229835 -- 153,688,210(+) TTGCG(C/T)AAATT reference, synonymous-codon
rs3891075 -- 153,685,711(+) AAGGC(A/T)GGATA intron-variant
rs4083382 -- 153,680,160(+) ctcAT(G/T)GCGCC intron-variant
rs5777877 -- 153,685,672(+) ATCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPR1 Gene

Variant ID Type Subtype PubMed ID
nsv464028 CNV Gain 19166990

Relevant External Links for NPR1 Gene

HapMap Linkage Disequilibrium report
NPR1
Human Gene Mutation Database (HGMD)
NPR1

Disorders for NPR1 Gene

(18) Novoseek inferred disease relationships for NPR1 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 52.3 6
essential hypertension 47.2 4
heart failure congestive 44.5 2
heart failure 38.9 3
hypertensive heart disease 34.7 2

Relevant External Links for NPR1

Genetic Association Database (GAD)
NPR1
Human Genome Epidemiology (HuGE) Navigator
NPR1
genes like me logo Genes that share disorders with NPR1: view

No data available for UniProtKB/Swiss-Prot for NPR1 Gene

Publications for NPR1 Gene

  1. Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina. (PMID: 7954658) Pardhasaradhi K. … Krishna G. (Cell. Mol. Neurobiol. 1994) 3 4 23
  2. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PMID: 1672777) Koller K.J. … Goeddel D.V. (Science 1991) 3 4 23
  3. Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family. (PMID: 1979052) Lowe D.G. … Goeddel D.V. (Genomics 1990) 2 3 23
  4. Organization of the human natriuretic peptide receptor A gene. (PMID: 9618281) Takahashi Y. … Kanmatsuse K. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  5. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PMID: 12872042) Pitzalis M.V. … Rizzon P. (J. Hypertens. 2003) 3 23 49

Products for NPR1 Gene

Sources for NPR1 Gene

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