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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPR1 Gene

protein-coding   GIFtS: 71
GCID: GC01P153651

Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic...


(Previous symbols: ANPRA, NPRA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic
Peptide Receptor A)1 2
     EC 4.6.1.23 8
ANPRA1 2 3 5     ANPa2
NPRA1 2     GUC2A2
Atrial Natriuretic Peptide Receptor Type A2 3     GUCY2A2
Guanylate Cyclase A2 3     Atrial Natriuretic Peptide Receptor 12
ANP-A2 3     Atrionatriuretic Peptide Receptor A2
ANPR-A2 3     Natriuretic Peptide A Type Receptor2
GC-A2 3     Natriuretic Peptide Receptor A2
NPR-A2 3     

External Ids:    HGNC: 79431   Entrez Gene: 48812   Ensembl: ENSG000001694187   OMIM: 1089605   UniProtKB: P160663   

Export aliases for NPR1 gene to outside databases

Previous GC identifers: GC01P151499 GC01P149382 GC01P150426 GC01P150867 GC01P150465 GC01P151917 GC01P125014


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPR1 Gene:
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms
(Garbers and Lowe, 1994 (PubMed 7982997)). The membrane guanylyl cyclases, often termed guanylyl cyclases A
through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular
ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein
kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides;
they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see
NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid
cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and
brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).(supplied by OMIM, May 2009)

GeneCards Summary for NPR1 Gene: 
NPR1 (natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)) is a protein-coding gene. Diseases associated with NPR1 include hypertensive heart disease, and priapism, and among its related super-pathways are G-Beta Gamma Signaling and Cellular Effects of Sildenafil. GO annotations related to this gene include GTP binding and protein kinase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066
Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which
are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity
upon binding of the ligand

summary for NPR1 Gene:
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl
cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved
catalytic and regulatory domains and divergent ligand binding domains. Natruiretic peptide receptors bind
alpha-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying
affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is
in homeostasis of body fluid volume.

Gene Wiki entry for NPR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPR1 gene promoter:
         E2F   E2F-1   Sp1   Nkx2-5   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21-q22

NPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153651:  view genomic region     (about GC identifiers)

Start:
153,651,113 bp from pter      End:
153,666,468 bp from pter
Size:
15,356 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066 (See protein sequence)
Recommended Name: Atrial natriuretic peptide receptor 1 precursor  
Size: 1061 amino acids; 118919 Da
Subunit: Homodimer (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B0ZBF0 Q5SR08 Q6P4Q3

Explore the universe of human proteins at neXtProt for NPR1: NX_P16066

Explore proteomics data for NPR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of the protein kinase-like domain is required for full activation by ANP (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16066

  • 4/16 DME Specific Peptides for NPR1 (P16066) (see all 16)
     QLRLRIG  NDIVKGM  LLNDLYT  FSDIVGFT 

    NPR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPR1 Protein Expression
    REFSEQ proteins: NP_000897.3  
    ENSEMBL proteins: 
     ENSP00000357669  

    Human Recombinant Protein Products for NPR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NPR1
    OriGene Protein Over-expression Lysate for NPR1
    OriGene MassSpec for NPR1 
    OriGene Custom Protein Services for NPR1
    GenScript Custom Purified and Recombinant Proteins Services for NPR1
    Novus Biologicals NPR1 Protein
    Novus Biologicals NPR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPR1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IC12547834

    NPR1 for ontologies           About GeneDecksing



    NPR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Custom Superior Antibodies Services for NPR1
    Novus Biologicals NPR1 Antibodies
    Abcam antibodies for NPR1
    Cloud-Clone Corp. Antibodies for NPR1 
    ThermoFisher Antibodies for NPR1
    LSBio Antibodies in human, mouse, rat for NPR1 

    Assay Products for NPR1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPR1 
    Cloud-Clone Corp. CLIAs for NPR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NPR-A 
    Natriuretic peptide receptor family

    5/7 InterPro protein domains (see all 7):
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001170 Ntpep_rcpt
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P16066

    ProtoNet protein and cluster: P16066

    2 Blocks protein domains:
    IPB001170 Natriuretic peptide receptor
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: ANPRA_HUMAN, P16066
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 1 guanylate cyclase domain
    Similarity: Contains 1 protein kinase domain


    NPR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANPRA_HUMAN, P16066
    Function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which
    are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity
    upon binding of the ligand
    Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate

         Genatlas biochemistry entry for NPR1:
    natriuretic peptide,receptor A,expressed in kidney,vascular endothelium and adrenal glands,responding to ANP
    (NPPA) and to a lesser degree to BNP by mediating vasorelaxant and natriuretic functions and decreasing
    aldosterone synthesis

         Enzyme Number (IUBMB): EC 4.6.1.21 2

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004383guanylate cyclase activity IDA1672777
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    NPR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NPR1:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Npr1):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  muscle  reproductive system  respiratory system 

    NPR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NPR1: Npr1tm1Mae Npr1tm1Gar

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPR1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR1:
    hsa-miR-767-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidNPR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPR1
    Sirion Biotech Customized adenovirus for overexpression of NPR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NPR1 (see all 7)
    OriGene ORF clones in mouse, rat for NPR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPR1 (NM_000906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR1
    Sirion Biotech Customized lentivirus for stable overexpression of NPR1 
                         Customized lentivirus expression plasmids for stable overexpression of NPR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPR1
    Search LifeMap BioReagents cell lines for NPR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPR1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-Beta Gamma Signaling
    CRHR Pathway0.44
    Relaxin Pathway0.37
    2Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    3CREB Pathway
    Intracellular Calcium Signaling0.50
    4Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    5Purine metabolism
    Purine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NPR1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Relaxin Pathway
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    CRHR Pathway


    2         Kegg Pathways  (Kegg details for NPR1):
        Purine metabolism
    Vascular smooth muscle contraction


    NPR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for NPR1 (P160662, 3 ENSP000003576694) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61913 I2D: score=3 
    PRKG1Q139763, ENSP000003630924I2D: score=2 STRING: ENSP00000363092
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    NPPAP011603, ENSP000003656634I2D: score=1 STRING: ENSP00000365663
    NPPBP168603, ENSP000003656514I2D: score=1 STRING: ENSP00000365651
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process IDA1672777
    GO:0006468protein phosphorylation ----
    GO:0007166cell surface receptor signaling pathway NAS12547834
    GO:0007168receptor guanylyl cyclase signaling pathway IDA1672777
    GO:0007589body fluid secretion TAS14960748

    NPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPR1 for compounds           About GeneDecksing

    EMD Millipore small molecules for NPR1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NPR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Brain natriuretic peptide (1-32) (human)Endogenous peptide agonist at ANP receptor A (NPR1)[124584-08-3]
    C-type natriuretic peptide (1-22) (human, rat, swine) Endogenous peptide agonist at NPR2[127869-51-6]
    Atrial natriuretic factor (1-28) (human, porcine) Endogenous peptide regulating blood pressure[91917-63-4]
    Atrial natriuretic factor (1-28) (rat)Endogenous peptide regulating blood pressure[88898-17-3]

    5 HMDB Compounds for NPR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    6 DrugBank Compounds for NPR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Isosorbide DinitrateDianhydrosorbitol 2,5-dinitrate (see all 4)87-33-2targetagonist17139284 16007231 12419094 15465035 17016423
    Erythrityl Tetranitrate1,2,3,4-Butanetetralyl tetranitrate (see all 13)7297-25-8targetagonist2895614 17139284 17016423
    NitroprussideDisodium nitroprusside dihydrate (see all 4)15078-28-1targetagonist16902599 17016498 15093694
    Amyl NitriteAmyl nitrosum (see all 6)110-46-3targetagonist19732062 12890708
    NitroglycerinGlyceryl trinitrate (see all 7)55-63-0targetagonist19732062 12890708
    NesiritideBNP (see all 3)124584-08-3targetbinder11752352

    7 IUPHAR Ligands for NPR1 (NPR-A)    About this table 
    LigandTypeActionAffinityPubmed IDs
    A-71915
    AntagonistAntagonist9.2 - 9.51680722
    [Asu7,23']β-ANP-(7-28)
    AntagonistAntagonist7.52542088
    atrial natriuretic peptide
    AgonistAgonist7.58700153
    [125I]ANP
    NoneNone7.5--
    anantin
    AntagonistAntagonist7.51826288
    sANP
    AgonistAgonist7.58700153
    brain natriuretic peptide
    AgonistAgonist7.58700153

    10/23 Novoseek inferred chemical compound relationships for NPR1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anantin 86.2 3 18223163 (2), 14583135 (1)
    cgmp 81.1 63 16902599 (6), 10537139 (3), 20097258 (3), 8613249 (2) (see all 34)
    urodilatin 80.5 4 9512977 (1), 9689013 (1), 20206222 (1)
    guanylate 67.1 19 7954658 (2), 18472099 (1), 19165164 (1), 19679847 (1) (see all 15)
    8-bromo cgmp 61.9 2 9689013 (1)
    disuccinimidyl suberate 51.9 2 1358197 (1), 1356991 (1)
    jasmonic acid 44.8 5 19716624 (2), 16415067 (1)
    amp-pnp 43 2 17848634 (1)
    sodium 25.8 3 9512977 (1), 12824076 (1), 20206222 (1)
    atp 20.6 8 16262696 (1), 9528788 (1), 17848634 (1), 8102767 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about NPR1 / ANPRA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPR1 gene: 
    NM_000906.3  

    Unigene Cluster for NPR1:

    Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
    Hs.490330  [show with all ESTs]
    Unigene Representative Sequence: BC063304
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368680(uc001fcs.4 uc010pdz.2 uc010pea.2) ENST00000413826
    ENST00000368677
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NPR1:
    hsa-miR-767-3p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidNPR1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for NPR1 (see all 7)
    OriGene ORF clones in mouse, rat for NPR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPR1 (NM_000906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPR1
    Sirion Biotech Customized lentivirus for stable overexpression of NPR1 
                         Customized lentivirus expression plasmids for stable overexpression of NPR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NPR1
    OriGene qSTAR qPCR primer pairs in human, mouse for NPR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPR1

    Additional mRNA sequence: 

    AK025024.1 AK298090.1 AK300446.1 BC063304.1 S72628.1 X15357.1 

    4 DOTS entries:

    DT.209401  DT.102840747  DT.95172149  DT.91710927 

    24/112 AceView cDNA sequences (see all 112):

    BQ888212 T28476 AI676183 AI884554 AI984876 R46749 BU728059 BQ896594 
    BQ721030 BE746385 AK025024 AI567201 AA978089 BQ017282 R46756 BE741410 
    S72628 BQ681250 BQ016270 AI190837 AI889834 AI803186 BE745457 CD110228 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NPR1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -           -           -                                                               
    SP4:                    -           -                                                               
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for NPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPR1 expression in normal human tissues (normalized intensities)      NPR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGAGACA
    NPR1 Expression
    About this image


    NPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Collecting Duct Cells Renal Collecting Duct System
             Metanephros
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             adipose tissue   
     
     Breast (NULL)
             MAMMARY GLAND   

    See NPR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPR1

    SOURCE GeneReport for Unigene cluster: Hs.490330
        SABiosciences Expression via Pathway-Focused PCR Arrays including NPR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Osmotic Stress in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NPR1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npr11 , 5 natriuretic peptide receptor 11, 5 86.75(n)1
    91.2(a)1
      3 (39.23 cM)5
    181601  NM_008727.51  NP_032753.51 
     904505915 
    lizard
    (Anolis carolinensis)
    Reptilia NPR16
    --
    Uncharacterized protein
    87(a)
    57(a)
    1 ↔ 1
    possible ortholog
    GL344609.1(16140-23785)
    AAWZ02036748(9649-20246)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687692 hypothetical protein MGC68769 77.56(n)    BC063739.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npr1a1 natriuretic peptide receptor 1a 66.14(n)
    64.5(a)
      560653  NM_001044937.2  NP_001038402.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57193
    CG32161
    guanylate cyclase3
    CG32161
    56(a)
    (best of 6)3
    54.41(n)1
    45.39(a)1
      55B123
    373761  NM_166415.21  NP_726013.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T01A4.1b3 guanylyl cyclase 58(a)
    (best of 24)
      I(4502610-4507720)   --


    ENSEMBL Gene Tree for NPR1 (if available)
    TreeFam Gene Tree for NPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPR1 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  GUCY2F2  ADCY82  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    15 SIMAP similar genes for NPR1 using alignment to 4 protein entries:     ANPRA_HUMAN (see all proteins):
    NPR2    ADCY4    GUCY1A2    GUCY1A3    GUCY1B3    GUCY2C
    ADCY5    ADCY8    ADCY1    ADCY2    ADCY3    NPRC
    GUCY2D    GUCY2F    ADCY7

    NPR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/533 SNPs in NPR1 are shown (see all 533)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422154
    A breast pleomorphic lobular carcinoma sample4--see VAR_0422152 F C mis40--------
    VAR_0422164
    ----see VAR_0422162 V M mis40--------
    rs1504131751,2
    --153649367(+) GTTATC/TCAGGA 1 -- us2k10--------
    rs1909965671,2
    --153649400(+) GGATCA/GCTTGA 1 -- us2k10--------
    rs120623021,2
    --153649430(+) gcctgA/Ggcaac 1 -- us2k10--------
    rs1868057121,2
    --153649529(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1382131771,2
    --153649632(+) CCCAAA/GTAGCT 1 -- us2k10--------
    rs617572811,2
    C,F--153649650(+) CAGGCG/TGCCGC 1 -- us2k11Minor allele frequency- T:0.00NS 556
    rs617572821,2
    C,F--153649747(+) ATCCAC/TCCACC 1 -- us2k11Minor allele frequency- T:0.01NS 556
    rs1432621451,2
    C--153649791(+) AGCCA-/CCTTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPR1 (153651113 - 153666468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NPR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv464028CNV Gain19166990


    Human Gene Mutation Database (HGMD): NPR1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NPR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 108960    OMIM disorders: --

    20/32 diseases for NPR1 (see all 32):    About MalaCards
    hypertensive heart disease    priapism    breast adenocarcinoma    acromesomelic dysplasia
    colon adenocarcinoma    aortic valve stenosis    cystic kidney    essential hypertension
    constipation    gigantism    cone-rod dystrophy    irritable bowel syndrome
    leber congenital amaurosis    hypertension    diarrhea    glaucoma
    adenocarcinoma    myocardial infarction    obesity    kidney disease

    6 diseases from the University of Copenhagen DISEASES database for NPR1:
    Hypertension     Leber congenital amaurosis     Constipation     Irritable bowel syndrome
    Heart disease     Diarrhea

    NPR1 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for NPR1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 52.3 10 10537139 (1), 15710627 (1), 9405681 (1), 12483301 (1) (see all 6)
    essential hypertension 47.2 5 10785505 (1), 16875975 (1), 10604494 (1), 12483301 (1)
    heart failure congestive 44.5 4 15710627 (1), 8760130 (1)
    heart failure 38.9 4 20171990 (1), 11511425 (1), 16778132 (1)
    hypertensive heart disease 34.7 3 9405681 (1), 12824076 (1)
    ventricular hypertrophy 23.6 2 10785505 (1), 12891290 (1)
    colon adenocarcinoma 18.5 1 16648657 (1)
    somatic mutations 4.9 3 14519099 (2)
    tumors 0.873 2 15710627 (1), 10529624 (1)
    glaucoma 0 4 17460430 (3)

    Genetic Association Database (GAD): NPR1
    Human Genome Epidemiology (HuGE) Navigator: NPR1 (17 documents)

    Export disorders for NPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPR1 gene, integrated from 9 sources (see all 235):
    (articles sorted by number of sources associating them with NPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population. (PubMed id 19126660)1, 4, 9 Tsezou A....Triposkiadis F. (2008)
    2. Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system. (PubMed id 18436476)1, 4, 9 Weber M....Geisslinger G. (2008)
    3. Investigation of the association between normal-tension glaucoma and single nucleotide polymorphisms in natriuretic peptide gene. (PubMed id 17460430)1, 4, 9 Jeoung J.W....Yoo T.W. (2007)
    4. Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. (PubMed id 16875975)1, 4, 9 Rubattu S....Stella P. (2006)
    5. Expression of mRNA for atrial natriuretic peptide receptor guanylate cyclase (ANPRA) in human retina. (PubMed id 7954658)1, 2, 9 Pardhasaradhi K.... Krishna G. (1994)
    6. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. (PubMed id 12872042)1, 4, 9 Pitzalis M.V....Rizzon P. (2003)
    7. Missense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarction. (PubMed id 14646971)1, 4, 9 Nakayama T....Kokubun S. (2003)
    8. Organization of the human natriuretic peptide receptor A gene. (PubMed id 9618281)1, 2, 9 Takahashi Y.... Kanmatsuse K. (1998)
    9. Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family. (PubMed id 1979052)1, 3, 9 Lowe D.G....Goeddel D.V. (1990)
    10. Multi-ethnic genetic association study of carotid int ima-media thickness using a targeted cardiovascular SNP microarray. (PubMed id 19679847)1, 4, 9 Lanktree M.B....Anand S.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4881 HGNC: 7943 AceView: NPR1 Ensembl:ENSG00000169418 euGenes: HUgn4881
    ECgene: NPR1 Kegg: 4881 H-InvDB: NPR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPR1 gene:
    Search GeneIP for patents involving NPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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