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Aliases & Descriptions for NPPC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| natriuretic peptide precursor C 2 |
|
| | Search outside databases for aliases for NPPC genePrevious GC identifers: GC02M230849 GC02M231521 GC02M232755 GC02M232992 GC02M232615 |
Summaries for NPPC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NPPC: Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[supplied by OMIM] UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582Function: Vasorelaxant activity. Has a cGMP-stimulating activityGene Wiki entry for NPPC (Natriuretic_peptide_precursor_C) |
Genomic Location for NPPC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NPPC gene 
Entrez Gene cytogenetic band: 2q24-qter Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q24-qterNPPC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M232498:
(about GC identifiers)
Start:
|
232,494,774 bp from pter |
End:
|
232,499,357 bp from pter |
Size:
|
4,584 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for NPPC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582 (See
protein sequence)Recommended Name: C-type natriuretic peptide precursor Size: 126 amino acids; 13246 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :1JDP (3D)
 
Secondary accessions: Q4ZG41REFSEQ proteins: NP_077720.1
ENSEMBL proteins: ENSP00000387159 ENSP00000295440
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- | About this table
Antibodies for NPPC: Assays for NPPC: | Protein
Domains/ Families for NPPC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P23582
ProtoNet protein and cluster: P23582 1 Blocks protein family: IPB002406 C-type natriuretic peptide signature
UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582Similarity: Belongs to the natriuretic peptide family | Gene Function for NPPC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024409
Applied Biosystems Silencer® siRNAs for NPPC
Sigma-Aldrich siRNA for NPPC  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024409                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024409                                  untagged cDNA clone in CMV expression vector: NM_024409 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024409
UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582Function: Vasorelaxant activity. Has a cGMP-stimulating activityGenatlas biochemistry entry for NPPC:natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the brain,also expressed in vascular endothelial cells and other tissues,present at extremely low level in circulation,potentially playing a paracrine/autocrine role7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nppc):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005179 | hormone activity |
IEA | -- | About this table | Pathways & Interactions for NPPC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for NPPC 
5/18 Interacting proteins for NPPC (ENSP000002954403) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006182 | cGMP biosynthetic process |
IEA | -- | | GO:0008217 | regulation of blood pressure |
NAS | -- | | GO:0009791 | post-embryonic development |
IEA | -- | | GO:0019229 | regulation of vasoconstriction |
NAS | -- | | GO:0040014 | regulation of multicellular organism growth |
IEA | -- | About this table
|
Drugs & Compounds for NPPC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NPPC 10/27 Novoseek chemical compound relationships for NPPC gene (see all 27
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cgmp |
85.61 |
183 |
8172609 (6), 12958024 (4), 7611424 (4), 2164803 (4) (see all 69) |
| guanylate |
75.50 |
21 |
9115758 (2), 7679284 (1), 12632516 (1), 18472099 (1) (see all 17) |
| 8-bromo cgmp |
73.49 |
13 |
14749356 (3), 11292628 (2), 7611424 (2), 11984695 (1) (see all 8) |
| 2',3'-cyclic nucleotide |
66.29 |
8 |
8065530 (2), 8390968 (1), 1666129 (1), 1710279 (1) (see all 6) |
| hanp |
58.44 |
6 |
12608696 (1), 9582102 (1) |
| 18alpha-glycyrrhetinic acid |
49.90 |
3 |
15140751 (1), 12552127 (1) |
| nitric oxide |
42.84 |
51 |
9361777 (5), 18617625 (3), 11304521 (3), 18514181 (3) (see all 22) |
| iberiotoxin |
42.58 |
2 |
17083062 (1), 18312283 (1) |
| sodium |
36.89 |
17 |
11076886 (3), 10068868 (3), 17454886 (2), 9495264 (2) (see all 6) |
| phosphothreonine |
35.67 |
1 |
8065530 (1) |
About this table
|
Transcripts for NPPC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024409
Sigma-Aldrich siRNA for NPPC  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024409 REFSEQ mRNAs for NPPC gene: NM_024409.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024409               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024409                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024409                                  untagged cDNA clone in CMV expression vector: NM_024409  Additional cDNA sequence: BC069120.1 BC105065.1 BC105067.1 1 DOTS entry: DT.91917815 2 AceView cDNA sequences:NM_024409 BC069120
highest scoring ESTs for NPPC:BC069120 NM_024409 BC105065 BC105067 BF976889 DR003533 Unigene Cluster for NPPC: Natriuretic peptide precursor C Hs.247916 Unigene Representative Sequence: BF976889
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000409852
ENST00000295440
|
Expression for NPPC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NPPC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NPPC
1 / 2 / 3 2 probe-sets matching NPPC gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCGGCCTGG
SOURCE GeneReport for Unigene cluster: Hs.247916
|
Orthologs for NPPC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NPPC gene from 5/6 species (see all 6
)
About this table Species with no ortholog for NPPC
ENSEMBL Gene Tree for NPPC | Paralogs for NPPC(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for NPPC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NPPC (up to first 250kb)
|
Disorders & Mutations for NPPC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600296
10/43 Novoseek disease relationships for NPPC gene (see all 43
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| heart failure |
52.09 |
10 |
16006261 (2), 17428580 (2), 13678415 (1), 8087930 (1) (see all 8) |
| heart failure congestive |
51.80 |
6 |
7878562 (3), 8117275 (1), 12909191 (1), 9034752 (1) |
| dwarfism |
45.96 |
3 |
17681481 (1), 14702637 (1), 17116261 (1) |
| cardiovascular diseases |
36.47 |
8 |
8743538 (1), 8117275 (1), 15749162 (1), 16179391 (1) (see all 5) |
| fluid overload |
31.39 |
1 |
8733825 (1) |
| achondroplasia |
30.17 |
2 |
14702637 (2) |
| cerebral vasospasm |
28.15 |
6 |
9254093 (2), 11178224 (2) |
| cor pulmonale |
15.87 |
5 |
7878562 (4), 8527262 (1) |
| cardiac hypertrophy |
13.35 |
2 |
17407830 (2) |
| vasospasm |
13.19 |
1 |
11178224 (1) |
About this table
Human Gene Mutation Database: NPPC Genetic Association Database: NPPC Human Genome Epidemiology Navigator: NPPC (2 documents)
|
Medical News for NPPC(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NPPC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/302 PubMed articles for NPPC gene (see all 302
):- Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). (PubMed id 7698765)1, 2, 3 Ogawa Y....Nakao K. (1994)
- Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. (PubMed id 1472040)1, 3, 4 Ishizaka Y....Matsuo H. (1992)
- C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. (PubMed id 8330189)1, 2, 3 Kaneko T....Hirai O. (1993)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. (PubMed id 12452325)3, 6 Ono K....Iwai N. (2002)
- Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. (PubMed id 11533490)3, 4 He X.-L.... Garcia K.C. (2001)
- Human C-type natriuretic peptide. Characterization of the gene and peptide. (PubMed id 1339402)3, 4 Ogawa Y.... Imura H. (1992)
- Gene and precursor structures of human C-type natriuretic peptide. (PubMed id 2018508)3, 4 Tawaragi Y....Matsuo H. (1991)
- CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome. (PubMed id 12167597)1, 3 Cataliotti A....Burnett J.C. (2002)
|
Search for NPPC
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NPPC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NPPC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPPC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NPPC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NPPC:

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