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NPPC Gene

protein-coding   GIFtS: 56

GC02M232498
natriuretic peptide precursor C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CNP 1, 2
CNP2 3
Descriptions
natriuretic peptide precursor C 2
External Ids
HGNC: 79411
Entrez Gene: 48802
UniProtKB: P235823
Ensembl: ENSG000001632737
Search outside databases for aliases for NPPC gene

Previous GC identifers: GC02M230849 GC02M231521 GC02M232755 GC02M232992 GC02M232615

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for NPPC:
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic
peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic
peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic,
diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood
pressure control.[supplied by OMIM]

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
Function: Vasorelaxant activity. Has a cGMP-stimulating activity

Gene Wiki entry for NPPC (Natriuretic_peptide_precursor_C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NPPC gene  

Entrez Gene cytogenetic band: 2q24-qter   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q24-qter

NPPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M232498:     (about GC identifiers)

Start:
232,494,774 bp from pter
End:
232,499,357 bp from pter
Size:
4,584 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582 (See protein sequence)
Recommended Name: C-type natriuretic peptide precursor  
Size: 126 amino acids; 13246 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :
1JDP (3D)    
Secondary accessions: Q4ZG41

REFSEQ proteins: NP_077720.1  

ENSEMBL proteins: 
ENSP00000387159 ENSP00000295440 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for NPPC  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (proCNP)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region NAS--
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Antibodies for NPPC: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for NPPC (CNP)
Antibodies from Abcam (proCNP), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NPPC)
Search Novus for antibodies for NPPC

Assays for NPPC: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR000663 Natr_peptide
 IPR002406 C_natriurtcpep


   GeneDecks  NPPC for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P23582

ProtoNet protein and cluster: P23582

1 Blocks protein family: IPB002406 C-type natriuretic peptide signature

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
Similarity: Belongs to the natriuretic peptide family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NPPC)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024409

              Applied Biosystems Silencer® siRNAs for NPPC

              Sigma-Aldrich siRNA for NPPC  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024409
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024409
                                 untagged cDNA clone in CMV expression vector: NM_024409 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024409

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
Function: Vasorelaxant activity. Has a cGMP-stimulating activity

Genatlas biochemistry entry for NPPC:
natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the
brain,also expressed in vascular endothelial cells and other tissues,present at extremely low
level in circulation,potentially playing a paracrine/autocrine role

7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nppc):

craniofacialendocrine/exocrine glandgrowth/sizelethality-postnatallimbs/digits/tail
reproductive systemskeleton

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005179 hormone activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  NPPC 


5/18 Interacting proteins for NPPC (ENSP000002954403) via UniProtKB, MINT, and/or STRING (see all 18 )
InteractantInteraction Details
GeneCardExternal ID(s)
NPR2ENSP000003410833STRING (score=.999)
NPR3ENSP000002650743STRING (score=.987)
NPPBENSP000003656513STRING (score=.909)
NPR1ENSP000003576693STRING (score=.908)
NPPAENSP000003656633STRING (score=.883)
About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006182 cGMP biosynthetic process IEA--
GO:0008217 regulation of blood pressure NAS--
GO:0009791 post-embryonic development IEA--
GO:0019229 regulation of vasoconstriction NAS--
GO:0040014 regulation of multicellular organism growth IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NPPC
10/27 Novoseek chemical compound relationships for NPPC gene (see all 27 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
cgmp 85.61 183 8172609 (6), 12958024 (4), 7611424 (4), 2164803 (4) (see all 69)
guanylate 75.50 21 9115758 (2), 7679284 (1), 12632516 (1), 18472099 (1) (see all 17)
8-bromo cgmp 73.49 13 14749356 (3), 11292628 (2), 7611424 (2), 11984695 (1) (see all 8)
2',3'-cyclic nucleotide 66.29 8 8065530 (2), 8390968 (1), 1666129 (1), 1710279 (1) (see all 6)
hanp 58.44 6 12608696 (1), 9582102 (1)
18alpha-glycyrrhetinic acid 49.90 3 15140751 (1), 12552127 (1)
nitric oxide 42.84 51 9361777 (5), 18617625 (3), 11304521 (3), 18514181 (3) (see all 22)
iberiotoxin 42.58 2 17083062 (1), 18312283 (1)
sodium 36.89 17 11076886 (3), 10068868 (3), 17454886 (2), 9495264 (2) (see all 6)
phosphothreonine 35.67 1 8065530 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NPPC)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024409

              Sigma-Aldrich siRNA for NPPC  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024409  

REFSEQ mRNAs for NPPC gene: 

NM_024409.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024409  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024409
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024409
                                 untagged cDNA clone in CMV expression vector: NM_024409 

Additional cDNA sequence: 

BC069120.1 BC105065.1 BC105067.1 

1 DOTS entry:

DT.91917815 

2 AceView cDNA sequences:

NM_024409 BC069120 

highest scoring ESTs for NPPC:

BC069120 NM_024409 BC105065 BC105067 BF976889 DR003533 

Unigene Cluster for NPPC:

Natriuretic peptide precursor C
Hs.247916
Unigene Representative Sequence: BF976889


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000409852  ENST00000295440  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NPPC expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NPPC

1 / 2 / 3

2 probe-sets matching NPPC gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

221348_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024409 0.60 1.00 0.82 1

221348_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGCGGCCTGG

SOURCE GeneReport for Unigene cluster: Hs.247916
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for NPPC gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
NPPC1   -- natriuretic peptide precursor C 93.65(n)
96.03(a)
610169  XM_847591.1  XP_852684.1 
chimpanzee
(Pan troglodytes)
NPPC1   -- natriuretic peptide precursor C 99.74(n)
99.21(a)
740147  XM_001141992.1  XP_001141992.1 
cow
(Bos taurus)
NPPC1   -- natriuretic peptide precursor C 92.59(n)
92.86(a)
281356  NM_174125.2  NP_776550.1 
rat
(Rattus norvegicus)
Nppc1   -- natriuretic peptide precursor C 89.42(n)
93.65(a)
114593  NM_053750.1  NP_446202.1 
mouse
(Mus musculus)
Nppc1, 5 1 (54.00 cM)5
natriuretic peptide precursor type C1, 5 88.36(n)1
91.27(a)1
181591  NM_010933.31  NP_035063.11 
 AK0361765  BC1118345  (see all 8)
About this table        Species with no ortholog for NPPC

ENSEMBL Gene Tree for NPPC
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/20 NCBI SNPs in NPPC are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs52621,2
A,C,F,H232500192(-) ACAGAG/AGGAGT 1 -- ng316Minor allele frequency- A:0.25MN EU EA WA 744
--
rs52641,2
A,C,F232499750(-) ACTTTC/ATGCCT 1 -- ng312Minor allele frequency- A:0.03MN 252
rs52681,2
A,C,F232498297(+) AAGGCT/CGGCTG 1 -- ng511Minor allele frequency- C:0.10MN 68
rs38115441,2
F,H232500427(-) GAGAGC/TAAGTT 1 -- ng314Minor allele frequency- T:0.05EU EA WA 418
rs52651,2
C,F232499313(-) GGACCC/GTGCTC 1 -- ng312Minor allele frequency- G:0.03MN 332
rs52631,2
F232500178(-) CCAGCG/AGAGTC 1 -- ng311Minor allele frequency- A:0.05MN 80
rs52671,2
F232498515(-) GTCGCG/AGGCAG 1 Q/R mis1 ese32Minor allele frequency- A:0.02MN 264
rs52611,2
F232500627(-) CCTGGG/TGACAG 1 -- ng311Minor allele frequency- T:0.05MN 80
rs38115451,2
H232500391(-) TGTCCC/GGAGAG 1 -- ng314Minor allele frequency- G:0.00EU EA WA 418
rs52661,2
F232498613(-) GGCGGT/CCAGAA 1 G/G syn1 ese32Minor allele frequency- C:0.01MN 252
About this table

HapMap Linkage Disequilibrium images for NPPC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600296

10/43 Novoseek disease relationships for NPPC gene (see all 43 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure 52.09 10 16006261 (2), 17428580 (2), 13678415 (1), 8087930 (1) (see all 8)
heart failure congestive 51.80 6 7878562 (3), 8117275 (1), 12909191 (1), 9034752 (1)
dwarfism 45.96 3 17681481 (1), 14702637 (1), 17116261 (1)
cardiovascular diseases 36.47 8 8743538 (1), 8117275 (1), 15749162 (1), 16179391 (1) (see all 5)
fluid overload 31.39 1 8733825 (1)
achondroplasia 30.17 2 14702637 (2)
cerebral vasospasm 28.15 6 9254093 (2), 11178224 (2)
cor pulmonale 15.87 5 7878562 (4), 8527262 (1)
cardiac hypertrophy 13.35 2 17407830 (2)
vasospasm 13.19 1 11178224 (1)
About this table

Human Gene Mutation Database: NPPC
Genetic Association Database: NPPC
Human Genome Epidemiology Navigator: NPPC (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/302 PubMed articles for NPPC gene (see all 302 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4880 HGNC: 7941 AceView: NPPC Ensembl:ENSG00000163273 euGenes: HUgn4880
ECgene: NPPC H-InvDB: NPPC
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for NPPC:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NPPC-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for NPPC Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Proteins for NPPC
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(proCNP)
 Antibodies (proCNP)
 Search OriGene for NPPC
 Search Tocris compounds for NPPC




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for NPPC

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