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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPPC Gene

protein-coding   GIFtS: 53
GCID: GC02M232786

Natriuretic Peptide C

(Previous name: natriuretic peptide precursor C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Natriuretic Peptide C1 2
Natriuretic Peptide Precursor C1 2
CNP22 3
CNP2
C-Type Natriuretic Peptide2

External Ids:    HGNC: 79411   Entrez Gene: 48802   Ensembl: ENSG000001632737   OMIM: 6002965   UniProtKB: P235823   

Export aliases for NPPC gene to outside databases

Previous GC identifers: GC02M230849 GC02M231521 GC02M232755 GC02M232992 GC02M232615 GC02M232498 GC02M224641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPPC Gene:
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic
peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate
chondrocytes and may also be vasoactive and natriuretic. (provided by RefSeq, Sep 2011)

GeneCards Summary for NPPC Gene: 
NPPC (natriuretic peptide C) is a protein-coding gene. Diseases associated with NPPC include cor pulmonale, and breast adenocarcinoma. GO annotations related to this gene include hormone activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate
chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and
stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)

Gene Wiki entry for NPPC (Natriuretic peptide precursor C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPPC gene promoter:
         HOXA9B   HOXA9   AP-4   HNF-4alpha2   RORalpha2   HNF-4alpha1   AREB6   Meis-1a   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPPC promoter sequence
   Search SABiosciences Chromatin IP Primers for NPPC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

NPPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPPC gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M232786:  view genomic region     (about GC identifiers)

Start:
232,786,530 bp from pter      End:
232,791,113 bp from pter
Size:
4,584 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582 (See protein sequence)
Recommended Name: C-type natriuretic peptide precursor  
Size: 126 amino acids; 13246 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for NPPC:
1JDP (3D)    
Secondary accessions: Q4ZG41

Explore the universe of human proteins at neXtProt for NPPC: NX_P23582

Explore proteomics data for NPPC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23582

  • NPPC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPPC Protein Expression
    REFSEQ proteins: NP_077720.1  
    ENSEMBL proteins: 
     ENSP00000387159   ENSP00000295440  

    Human Recombinant Protein Products for NPPC: 
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    OriGene Protein Over-expression Lysate for NPPC
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPPC
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    Novus Biologicals NPPC Protein
    Novus Biologicals NPPC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005615extracellular space IEA--

    NPPC for ontologies           About GeneDecksing



    NPPC Antibody Products: 
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    Abcam antibodies for NPPC
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for NPPC 

    Assay Products for NPPC: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000663 Natr_peptide
     IPR002406 C_natriurtcpep

    Graphical View of Domain Structure for InterPro Entry P23582

    ProtoNet protein and cluster: P23582

    1 Blocks protein domain: IPB002406 C-type natriuretic peptide signature

    UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
    Similarity: Belongs to the natriuretic peptide family


    NPPC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANFC_HUMAN, P23582
    Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate
    chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and
    stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)

         Genatlas biochemistry entry for NPPC:
    natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the brain,also expressed
    in vascular endothelial cells and other tissues,present at extremely low level in circulation,potentially playing
    a paracrine/autocrine role

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI1660465
    GO:0005179hormone activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0051428peptide hormone receptor binding IEA--
         
    NPPC for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nppc):
     craniofacial  endocrine/exocrine gland  growth/size  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  reproductive system  skeleton 

    NPPC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nppctm1Yog for NPPC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPPC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPPC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPPC 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPPC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPPC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for NPPC (P235823 ENSP000002954404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPR2P205943, ENSP000003410834I2D: score=2 STRING: ENSP00000341083
    NPR3P173423, ENSP000003980284I2D: score=2 STRING: ENSP00000398028
    MMEP084733, ENSP000003536794I2D: score=1 STRING: ENSP00000353679
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001666response to hypoxia IEA--
    GO:0003418growth plate cartilage chondrocyte differentiation ISS--
    GO:0003419growth plate cartilage chondrocyte proliferation ISS--
    GO:0006182cGMP biosynthetic process IDA1672777

    NPPC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPPC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPPC (ANFC)

    10/55 Novoseek inferred chemical compound relationships for NPPC gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urodilatin 90.8 25 17032349 (3), 16565701 (2), 10073597 (2), 8097089 (1) (see all 18)
    cgmp 85.2 191 8172609 (6), 12958024 (4), 7611424 (4), 2164803 (4) (see all 71)
    guanylate 74.4 21 9115758 (2), 7679284 (1), 12632516 (1), 18472099 (1) (see all 17)
    8-bromo cgmp 72.6 13 14749356 (3), 11292628 (2), 7611424 (2), 11984695 (1) (see all 8)
    2',3'-cyclic nucleotide 65.1 8 8065530 (2), 8390968 (1), 1666129 (1), 1710279 (1) (see all 6)
    ly 83583 64.3 8 12632516 (1), 17466389 (1)
    hanp 63.2 7 18850266 (1), 12608696 (1), 9582102 (1)
    kt 5823 60.7 1 15564589 (1)
    zaprinast 54.1 3 17466389 (1)
    thiorphan 52.3 4 9887994 (2), 11304521 (1)

    Search CenterWatch for drugs/clinical trials and news about NPPC / ANFC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPPC gene: 
    NM_024409.2  

    Unigene Clusters for NPPC:

    Natriuretic peptide C
    Hs.247916 , Hs.627236
    Unigene Representative Sequences: BF976889, NM_024409
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409852(uc002vsl.2) ENST00000295440(uc021vye.1)
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NPPC
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for NPPC (see all 6)
    OriGene ORF clones in mouse, rat for NPPC
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    GenScript: all cDNA clones in your preferred vector: NPPC (NM_024409)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPPC
    Sirion Biotech Customized lentivirus for stable overexpression of NPPC 
                         Customized lentivirus expression plasmids for stable overexpression of NPPC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NPPC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPPC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPPC

    Additional mRNA sequence: 

    HQ419060.1 JF420840.1 

    1 DOTS entry:

    DT.91917815 

    2 AceView cDNA sequences:

    NM_024409 BC069120 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPPC expression in normal human tissues (normalized intensities)      NPPC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGCCTGG
    NPPC Expression
    About this image


    NPPC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Spinal Cord (Nervous System)
             spinal cord/lateral wall/ventricular layer   
     
     Neural Tube (Nervous System)
             spinal cord/lateral wall/ventricular layer   

    See NPPC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPPC

    SOURCE GeneReport for Unigene clusters: Hs.247916 Hs.627236
        SABiosciences Expression via Pathway-Focused PCR Array including NPPC: 
              Hypertension in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPPC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NPPC gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nppc1 , 5 natriuretic peptide type C1, 5 88.36(n)1
    91.27(a)1
      1 (43.98 cM)5
    181591  NM_010933.51  NP_035063.11 
     866662935 
    lizard
    (Anolis carolinensis)
    Reptilia NPPC6
    natriuretic peptide C
    32(a)
    1 ↔ 1
    GL343304.1(997652-1016525)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88032 Xenopus laevis transcribed sequence with weak similarity more 72.63(n)    AW159572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NPPC (1 of 2)6
    NPPC (2 of 2)6
    natriuretic peptide C
    40(a)
    40(a)
    many → 1
    many → 1
    22(41667719-41674270)
    22(41578654-41584044)


    ENSEMBL Gene Tree for NPPC (if available)
    TreeFam Gene Tree for NPPC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 SNPs in NPPC are shown (see all 131)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158282501,2
    C,F--224643898(+) GGGGCC/TAGCAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1148605441,2
    C,F--224643939(+) TCTTCC/TGCTGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1467345201,2
    C--232786407(+) ATCCAC/GAATTG 1 -- ds50010--------
    rs9675111,2
    H--232786472(-) GCTGAG/AAAAGA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs1121227381,2
    C,F--232786487(+) GTCCTG/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs75644021,2
    C,F--232786567(+) TTTTAA/GCTAGT 1 -- ds50014Minor allele frequency- G:0.25NA WA 124
    rs1898501601,2
    --232786733(+) CTGTCA/GGTCTC 1 -- ds50010--------
    rs1811241281,2
    --232786881(+) TAAAAA/CAGCTG 1 -- ut310--------
    rs1861394461,2
    --232786916(+) AAAAAA/GAAAGA 1 -- ut310--------
    rs1880333051,2
    --232786947(+) AGCCAC/TATTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NPPC (232786530 - 232791113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NPPC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508892CNV Insertion20534489
    nsv428408CNV Gain+Loss18775914
    essv10235CNV CNV17122850
    dgv1292e1CNV Complex17122850
    dgv1293e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): NPPC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPPC
    DNA2.0 Custom Variant and Variant Library Synthesis for NPPC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600296    OMIM disorders: --

    20/48 diseases for NPPC (see all 48):    About MalaCards
    cor pulmonale    breast adenocarcinoma    acromesomelic dysplasia    achondroplasia
    aortic valve stenosis    plasmodium falciparum malaria    skeletal dysplasias    dwarfism
    phaeochromocytoma    chagas disease    congestive heart failure    vascular disease
    pheochromocytoma    klinefelter's syndrome    hypercholesterolemia    cystic fibrosis
    eclampsia    pre-eclampsia    malaria    nephrotic syndrome

    4 diseases from the University of Copenhagen DISEASES database for NPPC:
    Acromesomelic dysplasia     Achondroplasia     Congestive heart failure     Hypertension

    NPPC for disorders           About GeneDecksing

    10/44 Novoseek inferred disease relationships for NPPC gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 54.6 13 16006261 (2), 17428580 (2), 13678415 (1), 8087930 (1) (see all 11)
    heart failure congestive 51.2 6 7878562 (3), 8117275 (1), 12909191 (1), 9034752 (1)
    skeletal dysplasia 46.6 11 19282381 (3)
    dwarfism 44 3 17681481 (1), 14702637 (1), 17116261 (1)
    achondroplasia 40.3 5 14702637 (2), 19282381 (1)
    cardiovascular diseases 37.1 9 8743538 (1), 8117275 (1), 15749162 (1), 19620509 (1) (see all 6)
    fluid overload 29.2 1 8733825 (1)
    cerebral vasospasm 26.2 6 9254093 (2), 11178224 (2)
    cor pulmonale 14 5 7878562 (4), 8527262 (1)
    vasospasm 11.1 1 11178224 (1)

    Genetic Association Database (GAD): NPPC
    Human Genome Epidemiology (HuGE) Navigator: NPPC (9 documents)

    Export disorders for NPPC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPPC gene, integrated from 9 sources (see all 344):
    (articles sorted by number of sources associating them with NPPC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). (PubMed id 7698765)1, 3, 9 Ogawa Y....Nakao K. (1994)
    2. Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. (PubMed id 1472040)1, 2, 9 Ishizaka Y....Matsuo H. (1992)
    3. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. (PubMed id 8330189)1, 3, 9 Kaneko T....Hirai O. (1993)
    4. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)1, 2, 9 Koller K.J....Goeddel D.V. (1991)
    5. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    8. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4 Fox A.A....Body S.C. (2009)
    9. A genome-wide association study of northwestern Europ eans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (2009)
    10. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4880 HGNC: 7941 AceView: NPPC Ensembl:ENSG00000163273 euGenes: HUgn4880
    ECgene: NPPC H-InvDB: NPPC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPPC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPPC gene:
    Search GeneIP for patents involving NPPC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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