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NPPC Gene

protein-coding   GIFtS: 55
GCID: GC02M232786

Natriuretic Peptide C

(Previous name: natriuretic peptide precursor C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natriuretic Peptide C1 2
Natriuretic Peptide Precursor C1 2
CNP22 3
CNP2
C-Type Natriuretic Peptide2

External Ids:    HGNC: 79411   Entrez Gene: 48802   Ensembl: ENSG000001632737   OMIM: 6002965   UniProtKB: P235823   

Export aliases for NPPC gene to outside databases

Previous GC identifers: GC02M230849 GC02M231521 GC02M232755 GC02M232992 GC02M232615 GC02M232498 GC02M224641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPPC Gene:
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic
peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate
chondrocytes and may also be vasoactive and natriuretic. (provided by RefSeq, Sep 2011)

GeneCards Summary for NPPC Gene:
NPPC (natriuretic peptide C) is a protein-coding gene. Diseases associated with NPPC include cor pulmonale, and breast adenocarcinoma. GO annotations related to this gene include hormone activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate
chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and
stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)

Gene Wiki entry for NPPC (Natriuretic peptide precursor C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPPC gene promoter:
         HOXA9B   HOXA9   AP-4   HNF-4alpha2   RORalpha2   HNF-4alpha1   AREB6   Meis-1a   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPPC promoter sequence
   Search Chromatin IP Primers for NPPC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

NPPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPPC gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M232786:  view genomic region     (about GC identifiers)

Start:
232,786,530 bp from pter      End:
232,791,113 bp from pter
Size:
4,584 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582 (See protein sequence)
Recommended Name: C-type natriuretic peptide precursor  
Size: 126 amino acids; 13246 Da
1 PDB 3D structure from and Proteopedia for NPPC:
1JDP (3D)    
Secondary accessions: Q4ZG41

Explore the universe of human proteins at neXtProt for NPPC: NX_P23582

Explore proteomics data for NPPC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr34
  • Modification sites at PhosphoSitePlus

  • See NPPC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077720.1  
    ENSEMBL proteins: 
     ENSP00000387159   ENSP00000295440  

    NPPC Human Recombinant Protein Products:

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    Novus Biologicals NPPC Protein
    Novus Biologicals NPPC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NPPC
    Browse Proteins at Cloud-Clone Corp.

    NPPC Antibody Products:

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    Abcam antibodies for NPPC
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    LSBio Antibodies in human, mouse, rat for NPPC

    NPPC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR000663 Natr_peptide
     IPR002406 C_natriurtcpep

    Graphical View of Domain Structure for InterPro Entry P23582

    ProtoNet protein and cluster: P23582

    1 Blocks protein domain: IPB002406 C-type natriuretic peptide signature

    UniProtKB/Swiss-Prot: ANFC_HUMAN, P23582
    Similarity: Belongs to the natriuretic peptide family


    NPPC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANFC_HUMAN, P23582
    Function: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate
    chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and
    stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)

         Genatlas biochemistry entry for NPPC:
    natriuretic peptide precursor C homolog of mouse C type (CNP),most strongly expressed in the brain,also expressed
    in vascular endothelial cells and other tissues,present at extremely low level in circulation,potentially playing
    a paracrine/autocrine role

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI1660465
    GO:0005179hormone activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0051428peptide hormone receptor binding IEA--
         
    NPPC for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nppc):
     craniofacial  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  reproductive system  skeleton 

    NPPC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nppctm1Yog for NPPC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPPC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPPC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPPC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPPC

    miRNA
    Products:
        
    miRTarBase miRNAs that target NPPC:
    hsa-mir-193b-3p (MIRT016398)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NPPC

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NPPC

    Clone
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    OriGene clones in human, mouse for NPPC (see all 6)
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    GenScript: all cDNA clones in your preferred vector: NPPC (NM_024409)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPPC

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPPC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANFC_HUMAN, P23582: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0030141secretory granule IEA--

    NPPC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including NPPC: 
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NPPC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for NPPC (P235823 ENSP000002954404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPR2P205943, ENSP000003410834I2D: score=2 STRING: ENSP00000341083
    NPR3P173423, ENSP000003980284I2D: score=2 STRING: ENSP00000398028
    MMEP084733, ENSP000003536794I2D: score=1 STRING: ENSP00000353679
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001666response to hypoxia IEA--
    GO:0003418growth plate cartilage chondrocyte differentiation ISS--
    GO:0003419growth plate cartilage chondrocyte proliferation ISS--
    GO:0006182cGMP biosynthetic process IDA1672777

    NPPC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPPC (ANFC)

    Selected Novoseek inferred chemical compound relationships for NPPC gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urodilatin 90.8 25 17032349 (3), 16565701 (2), 10073597 (2), 8097089 (1) (see all 18)
    cgmp 85.2 191 8172609 (6), 12958024 (4), 7611424 (4), 2164803 (4) (see all 71)
    guanylate 74.4 21 9115758 (2), 7679284 (1), 12632516 (1), 18472099 (1) (see all 17)
    8-bromo cgmp 72.6 13 14749356 (3), 11292628 (2), 7611424 (2), 11984695 (1) (see all 8)
    2',3'-cyclic nucleotide 65.1 8 8065530 (2), 8390968 (1), 1666129 (1), 1710279 (1) (see all 6)
    ly 83583 64.3 8 12632516 (1), 17466389 (1)
    hanp 63.2 7 18850266 (1), 12608696 (1), 9582102 (1)
    kt 5823 60.7 1 15564589 (1)
    zaprinast 54.1 3 17466389 (1)
    thiorphan 52.3 4 9887994 (2), 11304521 (1)



    NPPC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPPC gene: 
    NM_024409.2  

    Unigene Clusters for NPPC:

    Natriuretic peptide C
    Hs.247916 , Hs.627236
    Unigene Representative Sequences: BF976889, NM_024409
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409852(uc002vsl.2) ENST00000295440(uc021vye.1)
    miRNA
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    Primer
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    OriGene qPCR primer pairs and template standards for NPPC
    OriGene qSTAR qPCR primer pairs in human, mouse for NPPC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NPPC
      QuantiTect SYBR Green Assays in human, mouse, rat NPPC
      QuantiFast Probe-based Assays in human, mouse, rat NPPC

    Additional mRNA sequence: 

    HQ419060.1 JF420840.1 

    1 DOTS entry:

    DT.91917815 

    2 AceView cDNA sequences:

    NM_024409 BC069120 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPPC expression in normal human tissues (normalized intensities)      NPPC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGCCTGG
    NPPC Expression
    About this image


    NPPC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
    NPPC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPPC Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.247916 Hs.627236
        Pathway & Disease-focused RT2 Profiler PCR Array including NPPC: 
              Hypertension in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPPC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPPC gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nppc1 , 5 natriuretic peptide type C1, 5 88.36(n)1
    91.27(a)1
      1 (43.98 cM)5
    181591  NM_010933.51  NP_035063.11 
     866662935 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88032 Xenopus laevis transcribed sequence with weak similarity more 72.63(n)    AW159572.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-126j24.31 si:ch211-126j24.3 59.3(n)
    45.26(a)
      570244  NM_001109940.1  NP_001103410.1 


    ENSEMBL Gene Tree for NPPC (if available)
    TreeFam Gene Tree for NPPC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPPC (see all 131)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158282501,2
    C,F--224643898(+) GGGGCC/TAGCAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1148605441,2
    C,F--224643939(+) TCTTCC/TGCTGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1467345201,2
    C--232786407(+) ATCCAC/GAATTG 1 -- ds50010--------
    rs9675111,2
    H--232786472(-) GCTGAG/AAAAGA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs1121227381,2
    C,F--232786487(+) GTCCTG/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs75644021,2
    C,F--232786567(+) TTTTAA/GCTAGT 1 -- ds50014Minor allele frequency- G:0.25NA WA 124
    rs1898501601,2
    --232786733(+) CTGTCA/GGTCTC 1 -- ds50010--------
    rs1811241281,2
    --232786881(+) TAAAAA/CAGCTG 1 -- ut310--------
    rs1861394461,2
    --232786916(+) AAAAAA/GAAAGA 1 -- ut310--------
    rs1880333051,2
    --232786947(+) AGCCAC/TATTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NPPC (232786530 - 232791113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NPPC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508892CNV Insertion20534489
    nsv428408CNV Gain+Loss18775914
    essv10235CNV CNV17122850
    dgv1292e1CNV Complex17122850
    dgv1293e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NPPC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPPC
    DNA2.0 Custom Variant and Variant Library Synthesis for NPPC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600296    OMIM disorders: --

    Selected diseases for NPPC (see all 54):    About MalaCards
    cor pulmonale    breast adenocarcinoma    acromesomelic dysplasia    achondroplasia
    skeletal dysplasias    aortic valve stenosis    plasmodium falciparum malaria    phaeochromocytoma
    dwarfism    intracranial hypertension    chagas disease    colon adenocarcinoma
    klinefelter's syndrome    congestive heart failure    vascular disease    pheochromocytoma
    septic shock    hypercholesterolemia    eating disorder    cystic fibrosis

    4 diseases from the University of Copenhagen DISEASES database for NPPC:
    Acromesomelic dysplasia     Achondroplasia     Congestive heart failure     Hypertension

    NPPC for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NPPC gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 54.6 13 16006261 (2), 17428580 (2), 13678415 (1), 8087930 (1) (see all 11)
    heart failure congestive 51.2 6 7878562 (3), 8117275 (1), 12909191 (1), 9034752 (1)
    skeletal dysplasia 46.6 11 19282381 (3)
    dwarfism 44 3 17681481 (1), 14702637 (1), 17116261 (1)
    achondroplasia 40.3 5 14702637 (2), 19282381 (1)
    cardiovascular diseases 37.1 9 8743538 (1), 8117275 (1), 15749162 (1), 19620509 (1) (see all 6)
    fluid overload 29.2 1 8733825 (1)
    cerebral vasospasm 26.2 6 9254093 (2), 11178224 (2)
    cor pulmonale 14 5 7878562 (4), 8527262 (1)
    vasospasm 11.1 1 11178224 (1)

    Genetic Association Database (GAD): NPPC
    Human Genome Epidemiology (HuGE) Navigator: NPPC (9 documents)

    Export disorders for NPPC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPPC gene, integrated from 10 sources (see all 347):
    (articles sorted by number of sources associating them with NPPC)
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    1. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC). (PubMed id 7698765)1, 3, 9 Ogawa Y....Nakao K. (Genomics 1994)
    2. Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. (PubMed id 1472040)1, 2, 9 Ishizaka Y....Matsuo H. (Biochem. Biophys. Res. Commun. 1992)
    3. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. (PubMed id 8330189)1, 3, 9 Kaneko T....Hirai O. (Brain Res. 1993)
    4. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)1, 2, 9 Koller K.J.... Goeddel D.V. (Science 1991)
    5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    8. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4 Fox A.A....Body S.C. (Anesthesiology 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4880 HGNC: 7941 AceView: NPPC Ensembl:ENSG00000163273 euGenes: HUgn4880
    ECgene: NPPC H-InvDB: NPPC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPPC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPPC gene:
    Search GeneIP for patents involving NPPC

    GeneCards and IP:
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