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Aliases for NPPB Gene

Aliases for NPPB Gene

  • Natriuretic Peptide B 2 3
  • Natriuretic Peptide Precursor B 2 3
  • Gamma-Brain Natriuretic Peptide 3 4
  • BNP 3 6
  • Brain Type Natriuretic Peptide 3
  • Natriuretic Peptides B 3
  • Natriuretic Protein 3

External Ids for NPPB Gene

Previous GeneCards Identifiers for NPPB Gene

  • GC01M011981
  • GC01M011762
  • GC01M011526
  • GC01M011627
  • GC01M011851
  • GC01M011073

Summaries for NPPB Gene

Entrez Gene Summary for NPPB Gene

  • This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

GeneCards Summary for NPPB Gene

NPPB (Natriuretic Peptide B) is a Protein Coding gene. Diseases associated with NPPB include systolic heart failure and constrictive pericarditis. Among its related pathways are Human Embryonic Stem Cell Pluripotency and MicroRNAs in cardiomyocyte hypertrophy. GO annotations related to this gene include receptor binding and diuretic hormone activity.

UniProtKB/Swiss-Prot for NPPB Gene

  • Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Wiki entry for NPPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPB Gene

Genomics for NPPB Gene

Regulatory Elements for NPPB Gene

Genomic Location for NPPB Gene

Start:
11,857,464 bp from pter
End:
11,858,935 bp from pter
Size:
1,472 bases
Orientation:
Minus strand

Genomic View for NPPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPB Gene

Proteins for NPPB Gene

  • Protein details for NPPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16860-ANFB_HUMAN
    Recommended name:
    Natriuretic peptides B
    Protein Accession:
    P16860
    Secondary Accessions:
    • B0ZBE9
    • Q6FGY0
    • Q9P2Q7

    Protein attributes for NPPB Gene

    Size:
    134 amino acids
    Molecular mass:
    14726 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90441.1; Type=Frameshift; Positions=44; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPPB Gene

neXtProt entry for NPPB Gene

Proteomics data for NPPB Gene at MOPED

Post-translational modifications for NPPB Gene

  • The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Glycosylation at Thr62, Ser63, Ser70, Thr74, Ser79, Thr84, and Thr97
  • Modification sites at PhosphoSitePlus

Other Protein References for NPPB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPPB Gene

Domains for NPPB Gene

Gene Families for NPPB Gene

HGNC:

Protein Domains for NPPB Gene

Suggested Antigen Peptide Sequences for NPPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16860

UniProtKB/Swiss-Prot:

ANFB_HUMAN :
  • P16860
Family:
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPB: view

Function for NPPB Gene

Molecular function for NPPB Gene

GENATLAS Biochemistry: natriuretic peptide precursor B,predominantly expressed in ventricles,also expressed in atria,present in the circulation and directly influencing blood pressure and body fluid homeostasis
UniProtKB/Swiss-Prot Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Ontology (GO) - Molecular Function for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12727915
GO:0005179 hormone activity NAS 7601467
GO:0005515 protein binding IPI 25416956
GO:0008613 diuretic hormone activity TAS 14960748
genes like me logo Genes that share ontologies with NPPB: view

Phenotypes for NPPB Gene

genes like me logo Genes that share phenotypes with NPPB: view

Animal Models for NPPB Gene

MGI Knock Outs for NPPB:

miRNA for NPPB Gene

miRTarBase miRNAs that target NPPB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPPB Gene

Localization for NPPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPPB Gene COMPARTMENTS Subcellular localization image for NPPB gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 14960748
GO:0005615 extracellular space NAS 7601467
GO:0043234 protein complex IDA 23382219
genes like me logo Genes that share ontologies with NPPB: view

Pathways for NPPB Gene

genes like me logo Genes that share pathways with NPPB: view

Pathways by source for NPPB Gene

1 GeneGo (Thomson Reuters) pathway for NPPB Gene

Gene Ontology (GO) - Biological Process for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0007166 cell surface receptor signaling pathway NAS 12727915
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007589 body fluid secretion TAS 14960748
GO:0008217 regulation of blood pressure NAS 12727915
genes like me logo Genes that share ontologies with NPPB: view

Compounds for NPPB Gene

UniProtKB/Swiss-Prot:

P16860-ANFB_HUMAN
Pharmaceutical: Available under the name Nesiritide (Scios). Used for the treatment of heart failure

(3) HMDB Compounds for NPPB Gene

Compound Synonyms Cas Number PubMed IDs
Aldosterone
  • (+)-Aldosterone
52-39-1
Testosterone
  • (+)-testosterone
58-22-0
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for NPPB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Carvedilol
72956-09-3 target other

(145) Novoseek inferred chemical compound relationships for NPPB Gene

Compound -log(P) Hits PubMed IDs
urodilatin 80.4 33
hanp 78.5 28
cgmp 74.1 215
creatinine 66.8 119
carvedilol 65.7 51
genes like me logo Genes that share compounds with NPPB: view

Transcripts for NPPB Gene

mRNA/cDNA for NPPB Gene

(41) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPB Gene

Natriuretic peptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPPB Gene

No ASD Table

Relevant External Links for NPPB Gene

GeneLoc Exon Structure for
NPPB
ECgene alternative splicing isoforms for
NPPB

Expression for NPPB Gene

mRNA expression in normal human tissues for NPPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPPB Gene

This gene is overexpressed in Heart - Atrial Appendage (37.9) and Heart - Left Ventricle (14.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPPB Gene

SOURCE GeneReport for Unigene cluster for NPPB Gene Hs.219140

mRNA Expression by UniProt/SwissProt for NPPB Gene

P16860-ANFB_HUMAN
Tissue specificity: Brain and also in atria, but at much lower levels than ANP
genes like me logo Genes that share expressions with NPPB: view

Orthologs for NPPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPPB 35
  • 99 (n)
  • 97.76 (a)
NPPB 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPPB 35
  • 73.13 (n)
  • 58.14 (a)
NPPB 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPPB 35
  • 67.86 (n)
  • 48.21 (a)
NPPB 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nppb 16
platypus
(Ornithorhynchus anatinus)
Mammalia NPPB 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPPA 36
  • 28 (a)
OneToOne
Species with no ortholog for NPPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPPB Gene

ENSEMBL:
Gene Tree for NPPB (if available)
TreeFam:
Gene Tree for NPPB (if available)

Paralogs for NPPB Gene

No data available for Paralogs for NPPB Gene

Variants for NPPB Gene

Sequence variations from dbSNP and Humsavar for NPPB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5227 - 11,858,760(-) AGGTC(G/T)TTCCC reference, missense
rs5228 -- 11,858,484(-) GACGC(C/G)CCCAT intron-variant
rs5229 - 11,858,462(-) GCAGC(A/G)CAACC missense, reference
rs5230 - 11,858,325(-) GCAAA(A/T)TGGTC reference, missense
rs198388 -- 11,857,283(+) ATATT(C/T)AATAA downstream-variant-500B

Relevant External Links for NPPB Gene

HapMap Linkage Disequilibrium report
NPPB
Human Gene Mutation Database (HGMD)
NPPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPPB Gene

Disorders for NPPB Gene

(4) University of Copenhagen DISEASES for NPPB Gene

(96) Novoseek inferred disease relationships for NPPB Gene

Disease -log(P) Hits PubMed IDs
heart failure 93.6 399
heart failure congestive 87.4 160
ventricular dysfunction left 86.1 129
ventricular dysfunction 78.4 71
ventricular dysfunction right 76.3 33

Relevant External Links for NPPB

Genetic Association Database (GAD)
NPPB
Human Genome Epidemiology (HuGE) Navigator
NPPB
genes like me logo Genes that share disorders with NPPB: view

No data available for UniProtKB/Swiss-Prot for NPPB Gene

Publications for NPPB Gene

  1. Association of the -381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss. (PMID: 12601551) Kajita M. … Emi M. (J. Hum. Genet. 2003) 3 23 48
  2. Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. (PMID: 16875975) Rubattu S. … Stella P. (J. Am. Coll. Cardiol. 2006) 3 23 48
  3. Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. (PMID: 17343213) Chiu C. … Semsarian C. (DNA Seq. 2006) 3 23 48
  4. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. (PMID: 17412758) Meirhaeghe A. … Amouyel P. (Hum. Mol. Genet. 2007) 3 23 48
  5. A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females. (PMID: 17554401) Kosuge K. … Matsumoto K. (Int J Med Sci 2007) 3 23 48

Products for NPPB Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Endothelial Cell Biology in human,mouse,rat
    • Hypertension in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NPPB
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NPPB
    • Block miRNA regulation of NPPB using miScript Target Protectors
    • Addgene plasmids for NPPB

    Sources for NPPB Gene

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