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Aliases for NPPB Gene

Aliases for NPPB Gene

  • Natriuretic Peptide B 2 3 5
  • Natriuretic Peptide Precursor B 2 3
  • Gamma-Brain Natriuretic Peptide 3 4
  • Brain Type Natriuretic Peptide 3
  • Natriuretic Peptides B 3
  • Natriuretic Protein 3
  • BNP 3

External Ids for NPPB Gene

Previous GeneCards Identifiers for NPPB Gene

  • GC01M011981
  • GC01M011762
  • GC01M011526
  • GC01M011627
  • GC01M011851
  • GC01M011073

Summaries for NPPB Gene

Entrez Gene Summary for NPPB Gene

  • This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

GeneCards Summary for NPPB Gene

NPPB (Natriuretic Peptide B) is a Protein Coding gene. Diseases associated with NPPB include Central Sleep Apnea and Acute Cor Pulmonale. Among its related pathways are cGMP-PKG signaling pathway and Human Embryonic Stem Cell Pluripotency. GO annotations related to this gene include receptor binding and diuretic hormone activity.

UniProtKB/Swiss-Prot for NPPB Gene

  • Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Wiki entry for NPPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPB Gene

Genomics for NPPB Gene

Regulatory Elements for NPPB Gene

Enhancers for NPPB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NPPB on UCSC Golden Path with GeneCards custom track

Genomic Location for NPPB Gene

Chromosome:
1
Start:
11,857,464 bp from pter
End:
11,858,935 bp from pter
Size:
1,472 bases
Orientation:
Minus strand

Genomic View for NPPB Gene

Genes around NPPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPB Gene

Proteins for NPPB Gene

  • Protein details for NPPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16860-ANFB_HUMAN
    Recommended name:
    Natriuretic peptides B
    Protein Accession:
    P16860
    Secondary Accessions:
    • B0ZBE9
    • Q6FGY0
    • Q9P2Q7

    Protein attributes for NPPB Gene

    Size:
    134 amino acids
    Molecular mass:
    14726 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90441.1; Type=Frameshift; Positions=44; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NPPB Gene

neXtProt entry for NPPB Gene

Post-translational modifications for NPPB Gene

  • The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Glycosylation at Thr 62, Ser 63, Ser 70, Thr 74, Ser 79, Thr 84, and Thr 97
  • Modification sites at PhosphoSitePlus

Other Protein References for NPPB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPPB Gene

Domains & Families for NPPB Gene

Gene Families for NPPB Gene

Protein Domains for NPPB Gene

Suggested Antigen Peptide Sequences for NPPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16860

UniProtKB/Swiss-Prot:

ANFB_HUMAN :
  • Belongs to the natriuretic peptide family.
Family:
  • Belongs to the natriuretic peptide family.
genes like me logo Genes that share domains with NPPB: view

Function for NPPB Gene

Molecular function for NPPB Gene

GENATLAS Biochemistry:
natriuretic peptide precursor B,predominantly expressed in ventricles,also expressed in atria,present in the circulation and directly influencing blood pressure and body fluid homeostasis
UniProtKB/Swiss-Prot Function:
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Gene Ontology (GO) - Molecular Function for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 1660465
GO:0005179 hormone activity NAS 7601467
GO:0005515 protein binding IPI 25416956
GO:0008613 diuretic hormone activity TAS 14960748
genes like me logo Genes that share ontologies with NPPB: view
genes like me logo Genes that share phenotypes with NPPB: view

Animal Model Products

CRISPR Products

miRNA for NPPB Gene

miRTarBase miRNAs that target NPPB

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NPPB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPPB Gene

Localization for NPPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPPB Gene COMPARTMENTS Subcellular localization image for NPPB gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 14960748
GO:0005615 extracellular space NAS 7601467
GO:0043234 protein complex IDA 23382219
genes like me logo Genes that share ontologies with NPPB: view

Pathways & Interactions for NPPB Gene

genes like me logo Genes that share pathways with NPPB: view

Pathways by source for NPPB Gene

1 BioSystems pathway for NPPB Gene
1 KEGG pathway for NPPB Gene

Gene Ontology (GO) - Biological Process for NPPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IDA 1672777
GO:0007166 cell surface receptor signaling pathway NAS 12727915
GO:0007168 receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007589 body fluid secretion TAS 14960748
GO:0008217 regulation of blood pressure NAS 12727915
genes like me logo Genes that share ontologies with NPPB: view

No data available for SIGNOR curated interactions for NPPB Gene

Drugs & Compounds for NPPB Gene

(109) Drugs for NPPB Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Antagonist, Target, other 157
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 524
oxymetholone Approved, Illicit Pharma Target 0
Water Approved Pharma 0
Aldosterone Experimental Pharma Agonist 0

(44) Additional Compounds for NPPB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Hydroxycarvedilol

(4) ApexBio Compounds for NPPB Gene

Compound Action Cas Number
Atrial natriuretic factor (1-28) (human, porcine) 91917-63-4
Atrial natriuretic factor (1-28) (rat) 88898-17-3
BNP (1-32), human Brain natriuretic peptide 114471-18-0
Brain natriuretic peptide (1-32) (human) 124584-08-3
genes like me logo Genes that share compounds with NPPB: view

Transcripts for NPPB Gene

mRNA/cDNA for NPPB Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPPB Gene

Natriuretic peptide B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NPPB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPPB Gene

No ASD Table

Relevant External Links for NPPB Gene

GeneLoc Exon Structure for
NPPB
ECgene alternative splicing isoforms for
NPPB

Expression for NPPB Gene

mRNA expression in normal human tissues for NPPB Gene

mRNA differential expression in normal tissues according to GTEx for NPPB Gene

This gene is overexpressed in Heart - Atrial Appendage (x37.9) and Heart - Left Ventricle (x14.7).

Protein differential expression in normal tissues from HIPED for NPPB Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPPB Gene



Protein tissue co-expression partners for NPPB Gene

NURSA nuclear receptor signaling pathways regulating expression of NPPB Gene:

NPPB

SOURCE GeneReport for Unigene cluster for NPPB Gene:

Hs.219140

mRNA Expression by UniProt/SwissProt for NPPB Gene:

P16860-ANFB_HUMAN
Tissue specificity: Brain and also in atria, but at much lower levels than ANP.
genes like me logo Genes that share expression patterns with NPPB: view

Primer Products

Orthologs for NPPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPPB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPPB 34
  • 73.13 (n)
  • 58.14 (a)
NPPB 35
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPPB 34
  • 67.86 (n)
  • 48.21 (a)
NPPB 35
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPPB 34
  • 99 (n)
  • 97.76 (a)
NPPB 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPPB 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPPA 35
  • 28 (a)
OneToOne
Species where no ortholog for NPPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPPB Gene

ENSEMBL:
Gene Tree for NPPB (if available)
TreeFam:
Gene Tree for NPPB (if available)

Paralogs for NPPB Gene

No data available for Paralogs for NPPB Gene

Variants for NPPB Gene

Sequence variations from dbSNP and Humsavar for NPPB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5227 - 11,858,760(-) AGGTC(G/T)TTCCC reference, missense
rs5229 - 11,858,462(-) GCAGC(A/G)CAACC reference, missense
rs5230 - 11,858,325(-) GCAAA(A/T)TGGTC reference, missense
rs5228 -- 11,858,484(-) GACGC(C/G/T)CCCAT intron-variant
rs198388 -- 11,857,283(+) ATATT(C/T)AATAA downstream-variant-500B

Variation tolerance for NPPB Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPPB Gene

Human Gene Mutation Database (HGMD)
NPPB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPPB Gene

Disorders for NPPB Gene

MalaCards: The human disease database

(50) MalaCards diseases for NPPB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
central sleep apnea
  • central sleep apnea syndrome
acute cor pulmonale
inferior myocardial infarction
  • inferior myocardial infarction nos
third-degree atrioventricular block
  • complete av block
systolic heart failure
  • heart failure, systolic
- elite association - COSMIC cancer census association via MalaCards
Search NPPB in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPPB

Genetic Association Database (GAD)
NPPB
Human Genome Epidemiology (HuGE) Navigator
NPPB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPPB
genes like me logo Genes that share disorders with NPPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPPB Gene

Publications for NPPB Gene

  1. Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy. (PMID: 19919978) Rame J.E. … Dries D.L. (Circ Heart Fail 2009) 3 22 46 65
  2. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. (PMID: 17412758) Meirhaeghe A. … Amouyel P. (Hum. Mol. Genet. 2007) 3 22 46 65
  3. A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females. (PMID: 17554401) Kosuge K. … Matsumoto K. (Int J Med Sci 2007) 3 22 46 65
  4. Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. (PMID: 17343213) Chiu C. … Semsarian C. (DNA Seq. 2006) 3 22 46 65
  5. Association of the -381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss. (PMID: 12601551) Kajita M. … Emi M. (J. Hum. Genet. 2003) 3 22 46 65

Products for NPPB Gene

Sources for NPPB Gene

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