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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NPPB Gene

protein-coding GIFtS: 65
GCID: GC01M011918

natriuretic peptide B

(Previous name: natriuretic peptide precursor B )

Explore 166 diseases affiliated with
NPPB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Natriuretic Peptide B¹ ²		Brain Type Natriuretic Peptide²
Natriuretic Peptide Precursor B¹ ²		Natriuretic Peptides B²
Gamma-Brain Natriuretic Peptide² ³		Natriuretic Protein²
BNP² ⁵

External Ids:	HGNC: 7940¹	Entrez Gene: 4879²	Ensembl: ENSG00000120937⁷	OMIM: 600295⁵	UniProtKB: P16860³

Export aliases for NPPB gene to outside databases

Previous GC identifers: GC01M011981 GC01M011762 GC01M011526 GC01M011627 GC01M011851 GC01M011073

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPPB:

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac

hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood.

The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone

secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is

indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860

Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in

cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone

secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor

NPR3

Gene Wiki entry for NPPB (Brain natriuretic peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NPPB gene promoter:
CREB AP-1 ATF-2 NRSF form 1 c-Jun Nkx2-5 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPPB promoter sequence

Search SABiosciences Chromatin IP Primers for NPPB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPPB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.2

NPPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPPB gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M011918: view genomic region (about GC identifiers)

Start:	11,917,521 bp from pter	End:	11,918,992 bp from pter
Size:	1,472 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860 (See protein sequence)

Recommended Name: Natriuretic peptides B precursor

Size: 134 amino acids; 14726 Da

Subcellular location: Secreted

Sequence caution: Sequence=BAA90441.1; Type=Frameshift; Positions=44;

2 PDB 3D structures from and Proteopedia for NPPB:

1YK1 (3D)

3N56 (3D)

Secondary accessions: B0ZBE9 Q6FGY0 Q9P2Q7

Explore the universe of human proteins at neXtProt for NPPB: NX_P16860

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16860

NPPB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002512.1

ENSEMBL proteins:

ENSP00000365651

Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for NPPB
	Uscn Proteins for NPPB

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	14960748
GO:0005615	extracellular space	NAS	7601467
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

NPPB for ontologies About GeneDecksing

NPPB Antibody Products:

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	Uscn ELISAs and CLIAs for NPPB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NPPB for domains About GeneDecksing

2 InterPro domains/families:

IPR000663 Natr_peptide

IPR002408 Natriuretic_peptide_brain

Graphical View of Domain Structure for InterPro Entry P16860

ProtoNet protein and cluster: P16860

1 Blocks protein family: IPB002408 Brain natriuretic peptide signature

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860

Similarity: Belongs to the natriuretic peptide family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860

Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in

cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone

secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor

NPR3

Genatlas biochemistry entry for NPPB:

natriuretic peptide precursor B,predominantly expressed in ventricles,also expressed in atria,present in the

circulation and directly influencing blood pressure and body fluid homeostasis

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPPB
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for NPPB

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NPPB
		Search LifeMap BioReagents cell lines for NPPB

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NPPB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	1660465
GO:0005179	hormone activity	NAS	7601467
GO:0008613	diuretic hormone activity	TAS	14960748
GO:0051428	peptide hormone receptor binding	IEA	--

NPPB for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Nppb^tm1Yog for NPPB
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nppb):

cardiovascular system

muscle

NPPB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Endothelin-1/EDNRA transactivation of EGFR

Development_Endothelin-1/EDNRA signaling

0.41

Development Endothelin-1/EDNRA signaling

0.41

Cardiomyocyte Differentiation through BMP Receptors

Cardiomyocyte Differentiation through BMP Receptors

1.00

MicroRNAs in cardiomyocyte hypertrophy

MicroRNAs in cardiomyocyte hypertrophy

1.00

Human Embryonic Stem Cell Pluripotency

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NPPB

Development Endothelin-1/EDNRA signaling

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NPPB

	Cardiomyocyte Differentiation through BMP Receptors
	Factors Promoting Cardiogenesis in Vertebrates

1 GeneGo (Thomson Reuters) Pathway for NPPB

Development Endothelin-1/EDNRA signaling

1 BioSystems Pathway for NPPB

MicroRNAs in cardiomyocyte hypertrophy

NPPB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NPPB

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/13 Interacting proteins for NPPB (P16860^{2, 3} ENSP00000365651⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8090889 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884²^,³, ENSP00000188790⁴	MINT-8090723 I2D: score=1 STRING: ENSP00000188790
NPR3	P17342³, ENSP00000398028⁴	I2D: score=2 STRING: ENSP00000398028
HDAC4	P56524³, ENSP00000264606⁴	I2D: score=1 STRING: ENSP00000264606
NPR1	P16066³, ENSP00000357669⁴	I2D: score=1 STRING: ENSP00000357669

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0006182	cGMP biosynthetic process	IDA	1672777
GO:0006954	inflammatory response	IEA	--
GO:0007166	cell surface receptor signaling pathway	NAS	12727915
GO:0007168	receptor guanylyl cyclase signaling pathway	IDA	1672777

NPPB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NPPB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPPB
UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860

Pharmaceutical: Available under the name Nesiritide (Scios). Used for the treatment of heart failure

3 HMDB Compounds for NPPB About this table

Compound	Synonyms	CAS #	PubMed Ids
Aldosterone	(+)-Aldosterone (see all 22)	52-39-1	--
Testosterone	(+)-testosterone (see all 86)	58-22-0	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for NPPB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Carvedilol	--	72956-09-3	target	other	14692707 15325927 15864245 11206715 11401111

10/145 Novoseek chemical compound relationships for NPPB gene (see all 145) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
urodilatin	80.4	53	10731654 (3), 17694372 (3), 10073597 (3), 17032349 (3) (see all 24)
hanp	78.5	36	19367029 (3), 15981667 (2), 17228802 (2), 9120798 (2) (see all 22)
cgmp	74.1	369	14587653 (11), 11865578 (10), 10441688 (8), 12879765 (6) (see all 99)
creatinine	66.8	223	15529559 (3), 16860526 (3), 17514627 (2), 17875951 (2) (see all 99)
carvedilol	65.7	74	11376305 (4), 17438403 (4), 18344152 (4), 15864245 (3) (see all 23)
levosimendan	65.5	28	15921958 (4), 19861257 (4), 18973957 (3), 19812809 (2) (see all 15)
norepinephrine	62.6	387	12628948 (10), 12417542 (8), 12879765 (7), 19635983 (5) (see all 99)
mibg	56.8	51	12541093 (3), 14960630 (3), 18199625 (3), 15981680 (2) (see all 20)
sodium	55.9	142	7963510 (6), 7795577 (5), 17942579 (4), 7576396 (4) (see all 60)
valsartan	54.4	26	12417542 (5), 12628948 (3), 16159967 (3), 16777915 (2) (see all 10)

Search CenterWatch for drugs/clinical trials and news about NPPB / ANFB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NPPB gene:

NM_002521.2

Unigene Cluster for NPPB:

Natriuretic peptide B

Hs.219140 [show with all ESTs]

Unigene Representative Sequence: BI833353

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376468(uc001atj.3) ENST00000474547

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPPB
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPPB

Additional cDNA sequence:

BC025785.1 CR541976.1 CR542003.1 M25296.1

3 DOTS entries:

DT.410586 DT.102825452 DT.95157748

24/41 AceView cDNA sequences (see all 41):

CR542003 BC025785 BI834766 CR541976 BI868417 AJ711307 BQ130258 BX099547

AJ710708 M25296 BQ130005 AW236964 AI186050 NM_002521 AA216138 AA216116

BF513130 AI968649 AJ708502 AJ707554 AI656014 BF569474 AJ707276 AJ708352

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NPPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCCCAGA

About this image

NPPB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Heart Tube

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Definitive endoderm-like cells (Generation of mesend...)

Posterior foregut-like cells (A scalable, suspensi...)

See NPPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPPB

SOURCE GeneReport for Unigene cluster: Hs.219140

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860

Tissue specificity: Brain and also in atria, but at much lower levels than ANP

SABiosciences Expression via Pathway-Focused PCR Arrays including NPPB:

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

Angiogenic Growth Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPPB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPPB

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NPPB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NPPB gene from 2/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nppb⁵	natriuretic peptide type B	--		4 (78.57 cM) 147985788
chicken (Gallus gallus)	Aves	ANF_CHICK⁶	Natriuretic peptides AAtrial natriuretic factor	26(a)	1 ↔ 1	21(5763069-5766207)

ENSEMBL Gene Tree for NPPB (if available)
TreeFam Gene Tree for NPPB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113086490^1,2		--	11917086(+)	`ATATTC/TGGGGC`	1	--	ds500¹		1		CSA	2
rs74823539^1,2	F,	--	11917096(+)	`CAGGAT/CGGAGG`	1	--	ds500¹		1		WA	118
rs186906707^1,2		--	11917110(+)	`CACCCC/TGGTAT`	1	--	ds500¹		0	--	--	--	--
rs143103745^1,2		--	11917158(+)	`CAGTCA/GTTGAC`	1	--	ds500¹		0	--	--	--	--
rs148220994^1,2		--	11917235(+)	`AGCAAA/GGACGA`	1	--	ds500¹		0	--	--	--	--
rs75285108^1,2	F,	--	11917285(+)	`CGTATC/ACTGCC`	1	--	ds500¹		1		WA	118
rs138266420^1,2		--	11917320(+)	`AAGTG-/CCTCAAGT`	1	--	ds500¹		0	--	--	--	--
rs198388^1,2	C,F,O,A,H,	--	11917340(+)	`ATATTC/TAATAA`	1	--	ds500¹		38		EA NA NS WA CSA	5739
rs59106704^1,2	C,	--	11917428(+)	`ATGCC-/TTGAGA`	1	--	ds500¹		0	--	--	--	--
rs58452163^1,2	C,	--	11917429(+)	`TGCCTC/TGAGAT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NPPB (11917521 - 11918992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NPPB: --
Human Gene Mutation Database (HGMD): NPPB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPPB

DNA2.0 Custom Variant and Variant Library Synthesis for NPPB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NPPB for disorders           About GeneDecksing

OMIM gene information: 600295    OMIM disorders: --

20/166 diseases for NPPB (see all 166):    About MalaCards

protein-losing enteropathy cor pulmonale arrhythmogenic right ventricular dysplasia ventricular septal defect

aldosteronism high blood pressure endocardial fibroelastosis end stage renal failure

acute cor pulmonale transposition of great arteries mitral valve insufficiency constrictive pericarditis

myocardial infarction atrial fibrillation patent ductus arteriosus transthyretin amyloidosis

central sleep apnea periventricular leukomalacia euthyroid sick syndrome inferior myocardial infarction

4 diseases from the University of Copenhagen DISEASES database for NPPB:

Heart disease Hypertension Eating disorder Central sleep apnea

10/96 Novoseek disease relationships for NPPB gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heart failure	93.6	1982	16800370 (8), 12411979 (7), 16601459 (7), 19167912 (6) (see all 99)
heart failure congestive	87.4	430	9857101 (5), 12934128 (5), 15940086 (5), 15101022 (4) (see all 99)
ventricular dysfunction left	86.1	224	16911545 (5), 17014518 (4), 12832317 (3), 9462585 (3) (see all 99)
ventricular dysfunction	78.4	92	15695131 (5), 19430339 (3), 14662720 (3), 17643533 (3) (see all 59)
ventricular dysfunction right	76.3	38	18626627 (4), 18563310 (2), 18043566 (1), 11255693 (1) (see all 29)
ventricular hypertrophy	71	102	8952587 (4), 12452317 (3), 10968202 (3), 11579366 (2) (see all 64)
heart diseases	70.8	207	11476749 (8), 9778544 (6), 16360967 (5), 12015190 (3) (see all 99)
cardiac death	69.8	69	15353502 (3), 16624649 (3), 17663815 (3), 12381941 (3) (see all 30)
atrial fibrillation	69.4	154	17496488 (5), 15494777 (5), 17456069 (3), 15529559 (3) (see all 88)
cardiac overload	69.1	19	18712044 (2), 17181125 (1), 9800882 (1), 17151299 (1) (see all 15)

Genetic Association Database (GAD): NPPB
Human Genome Epidemiology (HuGE) Navigator: NPPB (26 documents)

Export disorders for NPPB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPPB gene, integrated from 9 sources (see all 2681):
(articles sorted by number of sources associating them with NPPB)

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Human and canine gene homologs of porcine brain natriuretic peptide. (PubMed id 2597152)^{1, 2, 3} Seilhamer J.J.... Porter J.G. (1989)
Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PubMed id 16870210)^{1, 2, 9} He X.-L.... Garcia K.C. (2006)
Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)^{1, 2, 9} Koller K.J....Goeddel D.V. (1991)
Association of the -381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss. (PubMed id 12601551)^{1, 4, 9} Kajita M....Emi M. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Isolation and sequence determination of human brain natriuretic peptide in human atrium. (PubMed id 2136732)^{1, 2} Kambayashi Y.... Imura H. (1990)
Isolation and identification of human brain natriuretic peptides in cardiac atrium. (PubMed id 2138890)^{1, 2} Hino J.... Matsuo H. (1990)
Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide. (PubMed id 2522777)^{1, 2} Sudoh T.... Matsuo H. (1989)
Reduction in BNP levels with treatment of decompensated heart failure and future clinical events. (PubMed id 19398076)^{1, 9} Dhaliwal A.S....Bozkurt B. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4879	HGNC: 7940	AceView: NPPB	Ensembl:ENSG00000120937	euGenes: HUgn4879
ECgene: NPPB	H-InvDB: NPPB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NPPB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NPPB	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Brain_natriuretic_peptide

Intellectual Property for NPPB gene
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Patent Information for NPPB gene:
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natriuretic peptide B

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cardiac insufficiency
Apnea Central
essential hypertension
Premature Ventricular Contractions
sepsis
Death Sudden Cardiac
Cardiomyopathy Restrictive
Acute myocardial infarction
Tachyarrhythmia
Brain Hemorrhage
Left ventricular failure
Primary pulmonary hypertension
Myocardial Ischemia
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Edema
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CONGENITAL HEART DISEASE
MYOCARDIAL FIBROSIS
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HYPERTENSION ARTERIAL
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Diabetes Mellitus
Heart Failure Congestive
Ventricular Dysfunction Left
Subarachnoid Hemorrhage
Endocrine Effects
systemic hypertension
Ventricular Dysfunction
Myocarditis
Effects Cardiovascular
Right Heart Failure
Mitral Regurgitation
HEART FAILURE
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PULMONARY CONGESTION
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SIADH
Congestion
Lung diseases
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Apnea Sleep
ventricular hypertrophy
STROKE
fluid retention
ATRIAL ARRHYTHMIA
Paroxysmal atrial fibrillation
Acute pulmonary edema
Pulmonary Embolism
Ventricular dilatation
Dilated Cardiomyopathy
Renal Failure Chronic

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NPPB Gene

natriuretic peptide B

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