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NPPB Gene

protein-coding   GIFtS: 65
GCID: GC01M011918

Natriuretic Peptide B

(Previous name: natriuretic peptide precursor B)
  See NPPB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Natriuretic Peptide B1 2     Brain Type Natriuretic Peptide2
Natriuretic Peptide Precursor B1 2     Natriuretic Peptides B2
Gamma-Brain Natriuretic Peptide2 3     Natriuretic Protein2
BNP2 5     

External Ids:    HGNC: 79401   Entrez Gene: 48792   Ensembl: ENSG000001209377   OMIM: 6002955   UniProtKB: P168603   

Export aliases for NPPB gene to outside databases

Previous GC identifers: GC01M011981 GC01M011762 GC01M011526 GC01M011627 GC01M011851 GC01M011073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPPB Gene:
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a
cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into
the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin
and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in
the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal
osteoporosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for NPPB Gene:
NPPB (natriuretic peptide B) is a protein-coding gene. Diseases associated with NPPB include cor pulmonale, and systolic heart failure. GO annotations related to this gene include diuretic hormone activity and receptor binding.

UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860
Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key
role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and
aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the
clearance receptor NPR3

Gene Wiki entry for NPPB (Brain natriuretic peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPPB gene promoter:
         CREB   AP-1   ATF-2   NRSF form 1   c-Jun   Nkx2-5   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPPB promoter sequence
   Search Chromatin IP Primers for NPPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.2

NPPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPPB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011918:  view genomic region     (about GC identifiers)

Start:
11,917,521 bp from pter      End:
11,918,992 bp from pter
Size:
1,472 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860 (See protein sequence)
Recommended Name: Natriuretic peptides B precursor  
Size: 134 amino acids; 14726 Da
Sequence caution: Sequence=BAA90441.1; Type=Frameshift; Positions=44;
2 PDB 3D structures from and Proteopedia for NPPB:
1YK1 (3D)        3N56 (3D)    
Secondary accessions: B0ZBE9 Q6FGY0 Q9P2Q7

Explore the universe of human proteins at neXtProt for NPPB: NX_P16860

Explore proteomics data for NPPB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr62, Ser63, Ser70, Thr74, Ser79, Thr84, Thr97

  • See NPPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002512.1  
    ENSEMBL proteins: 
     ENSP00000365651  

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    Search eBioscience for ELISAs for NPPB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR000663 Natr_peptide
     IPR002408 Natriuretic_peptide_brain

    Graphical View of Domain Structure for InterPro Entry P16860

    ProtoNet protein and cluster: P16860

    1 Blocks protein domain: IPB002408 Brain natriuretic peptide signature

    UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860
    Similarity: Belongs to the natriuretic peptide family


    Find genes that share domains with NPPB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANFB_HUMAN, P16860
    Function: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key
    role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and
    aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the
    clearance receptor NPR3

         Genatlas biochemistry entry for NPPB:
    natriuretic peptide precursor B,predominantly expressed in ventricles,also expressed in atria,present in the
    circulation and directly influencing blood pressure and body fluid homeostasis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI12727915
    GO:0005179hormone activity NAS7601467
    GO:0008613diuretic hormone activity TAS14960748
         
    Find genes that share ontologies with NPPB           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nppb):
     cardiovascular system  muscle 

    Find genes that share phenotypes with NPPB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nppbtm1Yog for NPPB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPPB
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    hsa-mir-375 (MIRT019803)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANFB_HUMAN, P16860: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS14960748
    GO:0005615extracellular space NAS7601467
    GO:0043234protein complex IDA--

    Find genes that share ontologies with NPPB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPPB About    
    See pathways by source

    SuperPathContained pathways About
    1Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    2Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    3MicroRNAs in cardiomyocyte hypertrophy
    MicroRNAs in cardiomyocyte hypertrophy
    4Cardiomyocyte Differentiation through BMP Receptors
    Cardiomyocyte Differentiation through BMP Receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NPPB
        Cardiomyocyte Differentiation through BMP Receptors
    Factors Promoting Cardiogenesis in Vertebrates

    1 GeneGo (Thomson Reuters) Pathway for NPPB
        Development Endothelin-1/EDNRA signaling

    1 BioSystems Pathway for NPPB
        MicroRNAs in cardiomyocyte hypertrophy



        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPPB: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NPPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NPPB (P168602, 3 ENSP000003656514) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3, ENSP000003537314MINT-8090889 I2D: score=1 STRING: ENSP00000353731
    FAPQ128842, 3, ENSP000001887904MINT-8090723 I2D: score=1 STRING: ENSP00000188790
    NPR3P173423, ENSP000003980284I2D: score=2 STRING: ENSP00000398028
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    NPR1P160663, ENSP000003576694I2D: score=1 STRING: ENSP00000357669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006182cGMP biosynthetic process IDA1672777
    GO:0007166cell surface receptor signaling pathway NAS12727915
    GO:0007168receptor guanylyl cyclase signaling pathway IDA1672777
    GO:0007589body fluid secretion TAS14960748
    GO:0008217regulation of blood pressure NAS12727915

    Find genes that share ontologies with NPPB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPPB (ANFB)

    UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860
    Pharmaceutical: Available under the name Nesiritide (Scios). Used for the treatment of heart failure

    3 HMDB Compounds for NPPB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-1--
    Testosterone(+)-testosterone (see all 86)58-22-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for NPPB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carvedilol-- 72956-09-3targetother14692707 15325927 15864245 11206715 11401111

    Selected Novoseek inferred chemical compound relationships for NPPB gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urodilatin 80.4 53 10731654 (3), 17694372 (3), 10073597 (3), 17032349 (3) (see all 24)
    hanp 78.5 36 19367029 (3), 15981667 (2), 17228802 (2), 9120798 (2) (see all 22)
    cgmp 74.1 369 14587653 (11), 11865578 (10), 10441688 (8), 12879765 (6) (see all 99)
    creatinine 66.8 223 15529559 (3), 16860526 (3), 17514627 (2), 17875951 (2) (see all 99)
    carvedilol 65.7 74 11376305 (4), 17438403 (4), 18344152 (4), 15864245 (3) (see all 23)
    levosimendan 65.5 28 15921958 (4), 19861257 (4), 18973957 (3), 19812809 (2) (see all 15)
    norepinephrine 62.6 387 12628948 (10), 12417542 (8), 12879765 (7), 19635983 (5) (see all 99)
    mibg 56.8 51 12541093 (3), 14960630 (3), 18199625 (3), 15981680 (2) (see all 20)
    sodium 55.9 142 7963510 (6), 7795577 (5), 17942579 (4), 7576396 (4) (see all 60)
    valsartan 54.4 26 12417542 (5), 12628948 (3), 16159967 (3), 16777915 (2) (see all 10)



    Find genes that share compounds with NPPB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPPB gene: 
    NM_002521.2  

    Unigene Cluster for NPPB:

    Natriuretic peptide B
    Hs.219140  [show with all ESTs]
    Unigene Representative Sequence: BI833353
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376468(uc001atj.3)
    miRNA
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    Additional mRNA sequence: 

    BC025785.1 CR541976.1 CR542003.1 M25296.1 

    3 DOTS entries:

    DT.410586  DT.102825452  DT.95157748 

    Selected AceView cDNA sequences (see all 41):

    CR542003 BI834766 CR541976 BC025785 AW236964 BX099547 BQ130258 AI968649 
    AI186050 AJ710708 M25296 BQ130005 BI868417 AJ711307 BF513130 AA216138 
    NM_002521 AA216116 AJ707276 AI634108 AI656014 BF569474 AJ707554 CK905792 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCCCAGA
    NPPB Expression
    About this image


    NPPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells
    NPPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.219140

    UniProtKB/Swiss-Prot: ANFB_HUMAN, P16860
    Tissue specificity: Brain and also in atria, but at much lower levels than ANP

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPPB: 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NPPB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPPB gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nppb5 natriuretic peptide type B   --   4 (78.57 cM) 147985788 
    chicken
    (Gallus gallus)
    Aves NPPA6
    Gallus gallus natriuretic peptide B (NPPB), mRNA.
    28(a)
    1 ↔ 1
    21(5577062-5579681)


    ENSEMBL Gene Tree for NPPB (if available)
    TreeFam Gene Tree for NPPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPPB (see all 152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3750690971,2
    C--11076455(+) TAGTT-/TGGTGTG 1 -- us2k10--------
    rs617631211,2
    C--11076485(+) GTGTGT/CGTGCG 1 -- us2k12Minor allele frequency- C:0.02NS CSA 508
    rs37535801,2
    C,F--11076487(-) CACGCA/GCACAC 1 -- us2k16Minor allele frequency- G:0.32NA CSA EA 2294
    rs576037271,2
    C--11076487(+) GTGTG-/GTGTG 
    TGTGC
    /TG
    CGTGC
    1 -- us2k10--------
    rs630556661,2
    F--11076487(-) CACGC-/A/GCACAC 1 -- us2k11NS 506
    rs617631221,2
    C--11076489(+) GTGTGC/TGTGCA 1 -- us2k11Minor allele frequency- T:0.00NS 506
    rs617631231,2
    C,F--11076490(+) TGTGCG/ATGCAC 1 -- us2k11Minor allele frequency- A:0.01NS 506
    rs1130864901,2
    C,F--11917086(+) ATATTC/TGGGGC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs748235391,2
    C,F--11917096(+) CAGGAT/CGGAGG 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1869067071,2
    C--11917110(+) CACCCC/TGGTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NPPB (11917521 - 11918992 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPPB: --
    Human Gene Mutation Database (HGMD): NPPB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPPB
    DNA2.0 Custom Variant and Variant Library Synthesis for NPPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600295    OMIM disorders: --

    Selected diseases for NPPB (see all 49):    
    About MalaCards
    cor pulmonale    systolic heart failure    third-degree atrioventricular block    pulmonary edema
    constrictive pericarditis    acute cor pulmonale    central sleep apnea    inferior myocardial infarction
    stress cardiomyopathy    univentricular heart    cirrhotic cardiomyopathy    diastolic heart failure
    pulmonary embolism    syndrome of inappropriate antidiuretic hormone    hypertensive heart disease    vici syndrome
    cardiogenic shock    chagas disease    pericarditis    pericardial effusion

    4 diseases from the University of Copenhagen DISEASES database for NPPB:
    Heart disease     Hypertension     Eating disorder     Central sleep apnea

    Find genes that share disorders with NPPB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NPPB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 93.6 1982 16800370 (8), 12411979 (7), 16601459 (7), 19167912 (6) (see all 99)
    heart failure congestive 87.4 430 9857101 (5), 12934128 (5), 15940086 (5), 15101022 (4) (see all 99)
    ventricular dysfunction left 86.1 224 16911545 (5), 17014518 (4), 12832317 (3), 9462585 (3) (see all 99)
    ventricular dysfunction 78.4 92 15695131 (5), 19430339 (3), 14662720 (3), 17643533 (3) (see all 59)
    ventricular dysfunction right 76.3 38 18626627 (4), 18563310 (2), 18043566 (1), 11255693 (1) (see all 29)
    ventricular hypertrophy 71 102 8952587 (4), 12452317 (3), 10968202 (3), 11579366 (2) (see all 64)
    heart diseases 70.8 207 11476749 (8), 9778544 (6), 16360967 (5), 12015190 (3) (see all 99)
    cardiac death 69.8 69 15353502 (3), 16624649 (3), 17663815 (3), 12381941 (3) (see all 30)
    atrial fibrillation 69.4 154 17496488 (5), 15494777 (5), 17456069 (3), 15529559 (3) (see all 88)
    cardiac overload 69.1 19 18712044 (2), 17181125 (1), 9800882 (1), 17151299 (1) (see all 15)

    Genetic Association Database (GAD): NPPB
    Human Genome Epidemiology (HuGE) Navigator: NPPB (26 documents)

    Export disorders for NPPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPPB gene, integrated from 10 sources (see all 2769):
    (articles sorted by number of sources associating them with NPPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and canine gene homologs of porcine brain natriuretic peptide. (PubMed id 2597152)1, 2, 3 Seilhamer J.J.... Porter J.G. (Biochem. Biophys. Res. Commun. 1989)
    2. Mutation analysis of the natriuretic peptide precursor B (NPPB) gene in patients with hypertrophic cardiomyopathy. (PubMed id 17343213)1, 4, 9 Chiu C....Semsarian C. (DNA Seq. 2006)
    3. A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females. (PubMed id 17554401)1, 4, 9 Kosuge K....Matsumoto K. (Int J Med Sci 2007)
    4. Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. (PubMed id 16875975)1, 4, 9 Rubattu S....Stella P. (J. Am. Coll. Cardiol. 2006)
    5. Structural determinants of natriuretic peptide receptor specificity and degeneracy. (PubMed id 16870210)1, 2, 9 He X.-L.... Garcia K.C. (J. Mol. Biol. 2006)
    6. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). (PubMed id 1672777)1, 2, 9 Koller K.J.... Goeddel D.V. (Science 1991)
    7. Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy. (PubMed id 19919978)1, 4, 9 Rame J.E....Dries D.L. (Circ Heart Fail 2009)
    8. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. (PubMed id 17412758)1, 4, 9 Meirhaeghe A....Amouyel P. (Hum. Mol. Genet. 2007)
    9. Association of the -381T/C promoter variation of the brain natriuretic peptide gene with low bone-mineral density and rapid postmenopausal bone loss. (PubMed id 12601551)1, 4, 9 Kajita M....Emi M. (J. Hum. Genet. 2003)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4879 HGNC: 7940 AceView: NPPB Ensembl:ENSG00000120937 euGenes: HUgn4879
    ECgene: NPPB H-InvDB: NPPB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NPPB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NPPB Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Brain_natriuretic_peptide

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NPPB gene:
    Search GeneIP for patents involving NPPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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