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Aliases for NPPA-AS1 Gene

Subcategory (RNA class) for NPPA-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for NPPA-AS1 Gene

  • NPPA Antisense RNA 1 2 3 5
  • NPPA Antisense RNA 1 (Non-Protein Coding) 2 3
  • NPPA Antisense RNA (Non-Protein Coding) 2
  • NPPA-AS 3
  • NPPAAS 3

External Ids for NPPA-AS1 Gene

Previous HGNC Symbols for NPPA-AS1 Gene

  • NPPAAS
  • NPPA-AS

Previous GeneCards Identifiers for NPPA-AS1 Gene

  • GC01U903122
  • GC01P011905
  • GC01P011907
  • GC01P011844
  • GC01P011846
  • GC01P011848
  • GC01P011849
  • GC01P011850
  • GC01P011851

Summaries for NPPA-AS1 Gene

GeneCards Summary for NPPA-AS1 Gene

NPPA-AS1 (NPPA Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for NPPA-AS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPPA-AS1 Gene

Genomics for NPPA-AS1 Gene

Regulatory Elements for NPPA-AS1 Gene

Enhancers for NPPA-AS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H011840 1.4 Ensembl ENCODE 44.3 +1.9 1911 3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 NPPA-AS1 TARDBP ENSG00000226849 EXOSC10 MTHFR CLCN6 MIIP ENSG00000276470 GC01P011841 PIR58989
GH01H011838 0.9 ENCODE 42.1 -1.5 -1481 0 ELF3 HDGF RB1 ARID4B KLF17 ZNF2 RAD21 ZNF143 RCOR1 ZNF391 NPPA-AS1 MTHFR
GH01H011784 1.8 VISTA Ensembl ENCODE dbSUPER 17.4 -51.7 -51667 9 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 MTHFR NPPA-AS1 CLCN6 AGTRAP NPPB PIR55960 GC01M011790 LOC102724659
GH01H011795 1.6 Ensembl ENCODE dbSUPER 18.2 -42.9 -42923 4 HDGF PKNOX1 ARNT ZNF766 CBX5 ZC3H11A REST MEF2D SMARCA4 NBN TARDBP CLCN6 NPPA-AS1 ENSG00000226849 MTHFR EXOSC10 AGTRAP NPPB GC01M011785
GH01H011813 1.1 Ensembl ENCODE dbSUPER 22 -25.5 -25451 2 ZNF217 SMARCA5 NR2F1 IKZF1 CEBPB DPF2 NPPA-AS1 CLCN6 NPPB PLOD1 KIAA2013 MTHFR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPPA-AS1 Gene

Chromosome:
1
Start:
11,840,319 bp from pter
End:
11,848,079 bp from pter
Size:
7,761 bases
Orientation:
Plus strand

Genomic View for NPPA-AS1 Gene

Genes around NPPA-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPPA-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPPA-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPPA-AS1 Gene

Proteins for NPPA-AS1 Gene

Post-translational modifications for NPPA-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPPA-AS1 Gene

Domains & Families for NPPA-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NPPA-AS1 Gene

Function for NPPA-AS1 Gene

Phenotypes From GWAS Catalog for NPPA-AS1 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NPPA-AS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPPA-AS1 Gene

Localization for NPPA-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NPPA-AS1 Gene

Pathways & Interactions for NPPA-AS1 Gene

SuperPathways for NPPA-AS1 Gene

No Data Available

Interacting Proteins for NPPA-AS1 Gene

Gene Ontology (GO) - Biological Process for NPPA-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPPA-AS1 Gene

Drugs & Compounds for NPPA-AS1 Gene

(3) Drugs for NPPA-AS1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 17
Furosemide Approved, Vet_approved Pharma Agonist GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA 201
Torasemide Approved Pharma 0
genes like me logo Genes that share compounds with NPPA-AS1: view

Transcripts for NPPA-AS1 Gene

mRNA/cDNA for NPPA-AS1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NPPA-AS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NPPA-AS1 Gene

No ASD Table

Relevant External Links for NPPA-AS1 Gene

GeneLoc Exon Structure for
NPPA-AS1
ECgene alternative splicing isoforms for
NPPA-AS1

Expression for NPPA-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPPA-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for NPPA-AS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x51.2).
genes like me logo Genes that share expression patterns with NPPA-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPPA-AS1 Gene

Orthologs for NPPA-AS1 Gene

Evolution for NPPA-AS1 Gene

ENSEMBL:
Gene Tree for NPPA-AS1 (if available)
TreeFam:
Gene Tree for NPPA-AS1 (if available)

No data available for Orthologs for NPPA-AS1 Gene

Paralogs for NPPA-AS1 Gene

No data available for Paralogs for NPPA-AS1 Gene

Variants for NPPA-AS1 Gene

Sequence variations from dbSNP and Humsavar for NPPA-AS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs202102042 Pathogenic 11,847,114(+) TTACC(C/T)GGAAG intron-variant, reference, missense
rs587776851 Pathogenic 11,846,008(+) TTATC(-/TT)CAGTA intron-variant
rs755212754 Likely benign 11,847,311(+) TCCCC(A/G)GTCCA intron-variant, reference, synonymous-codon
rs749353276 Uncertain significance 11,847,310(+) TTCCC(C/T)GGTCC intron-variant, reference, missense
rs770401799 Uncertain significance 11,847,607(+) ATGGG(A/T)TTAGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NPPA-AS1 Gene

Variant ID Type Subtype PubMed ID
nsv527521 CNV loss 19592680

Relevant External Links for NPPA-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPPA-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NPPA-AS1 Gene

Disorders for NPPA-AS1 Gene

Relevant External Links for NPPA-AS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPPA-AS1

No disorders were found for NPPA-AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPPA-AS1 Gene

Publications for NPPA-AS1 Gene

  1. Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression. (PMID: 19671135) Annilo T … Laan M (BMC molecular biology 2009) 2 3 60
  2. Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. (PMID: 21273288) Del Greco M F … Pramstaller PP (Human molecular genetics 2011) 3 60

Products for NPPA-AS1 Gene

Sources for NPPA-AS1 Gene

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