Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPNT Gene

protein-coding   GIFtS: 51
GCID: GC04P106816

nephronectin
 Explore 7 diseases affiliated with
NPNT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPNT    

Aliases
for NPNT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nephronectin1
EGFL6L1 2 3
POEM1 2 3
Preosteoblast EGF-Like Repeat Protein With MAM Domain2 3
Protein EGFL6-Like3

External Ids:    HGNC: 274051   Entrez Gene: 2557432   Ensembl: ENSG000001687437   OMIM: 6103065   UniProtKB: Q6UXI93   

Export aliases for NPNT gene to outside databases

Previous GC identifers: GC04P107175 GC04P107036 GC04P102551


Summaries
for NPNT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NPNT_HUMAN, Q6UXI9
Function: Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with
integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and
function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins
(By similarity)




Genomic Views
for NPNT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPNT gene promoter:
         STAT1   AP-1   Bach2   ATF-2   STAT1alpha   E47   Evi-1   HEN1   COMP1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPNT promoter sequence
   Search SABiosciences Chromatin IP Primers for NPNT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPNT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q25

NPNT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPNT gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P106816:  view genomic region     (about GC identifiers)

Start:
 106,815,932 bp from pter      End:
 106,925,184 bp from pter
Size:
 109,253 bases      Orientation:
 plus strand

Proteins
for NPNT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPNT_HUMAN, Q6UXI9 (See protein sequence)
Recommended Name: Nephronectin precursor  
Size: 565 amino acids; 61907 Da
Subunit: Homodimer and homotrimer (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity). Note=Trapped on the cell
surface or in the extracellular matrix (By similarity)
Developmental stage: Expressed in fetal kidney, cochlea, eye, heart and lung
Secondary accessions: A6NFT9 A8K1W4 B4DIT4 B4DYK3 B4E2H7 B4E3H2 D6RCA1 E9PCK8 E9PCQ1 E9PE64 E9PF04
Alternative splicing: 6 isoforms:  Q6UXI9-1   Q6UXI9-2   Q6UXI9-3   Q6UXI9-4   Q6UXI9-5   Q6UXI9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPNT: NX_Q6UXI9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UXI9

    • NPNT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001028219.1  NP_001171619.1  NP_001171620.1  NP_001171621.1  NP_001171622.1  

    ENSEMBL proteins: 
     ENSP00000426951   ENSP00000369323   ENSP00000402884   ENSP00000389252   ENSP00000422044  
     ENSP00000302557   ENSP00000422474   ENSP00000426146   ENSP00000427507   ENSP00000421480  
     ENSP00000426219  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NPNT 
    GenScript Custom Purified and Recombinant Proteins Services for NPNT
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPNT

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS15754038
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005604basement membrane ----
    GO:0016020membrane IEA--
    GO:0030485smooth muscle contractile fiber ----


    NPNT for ontologies           About GeneDecksing



    NPNT Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NPNT (Nephronectin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NPNT 
    GenScript Custom Superior Antibodies Services for NPNT
    Novus Biologicals NPNT Antibodies
    Search for Antibodies for NPNT at Abcam  
    Uscn Antibodies for NPNT
    Search ThermoFisher Antibodies for NPNT

    Assay Products for NPNT: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPNT
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NPNT

    Protein Domains /
    Families
    for NPNT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPNT for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001881 EGF-like_Ca-bd
     IPR000998 MAM_dom
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q6UXI9

    ProtoNet protein and cluster: Q6UXI9

    1 Blocks protein family: IPB001881 EGF-like calcium-binding

    UniProtKB/Swiss-Prot: NPNT_HUMAN, Q6UXI9
    Domain: The MAM domain is required for localization at the cell surface (By similarity)
    Similarity: Belongs to the nephronectin family
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 MAM domain


    Function
    for NPNT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPNT_HUMAN, Q6UXI9
    Function: Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with
    integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and
    function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins
    (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target NPNT:
    hsa-mir-378 (MIRT005422)

    OriGene 3'-UTR Clone: NPNT
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPNT
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NPNT (see all 59):
    hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-25 hsa-miR-301a hsa-miR-578 hsa-miR-570 hsa-miR-3142 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NPNT 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPNT (see all 4)
    OriGene shRNA RFP: NPNT
    OriGene siRNA: NPNT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPNT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPNT

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NPNT (NM_001033047)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPNT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPNT 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NPNT
    Search LifeMap BioReagents cell lines for NPNT

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPNT

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding NAS11470831
    GO:0005509calcium ion binding IEA--


    NPNT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NPNT:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Npnttm1.1Lfr for NPNT
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Npnt):
     no phenotypic analysis  renal/urinary system 

    NPNT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPNT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPNT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NPNT (Q6UXI93 ENSP000003693234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA8P537083, ENSP000003673164I2D: score=2 STRING: ENSP00000367316
    ITGB1ENSP000003640944STRING: ENSP00000364094
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001657ureteric bud development ISS15754038
    GO:0001658branching involved in ureteric bud morphogenesis ISS15754038
    GO:0007160cell-matrix adhesion ISS15754038
    GO:0010694positive regulation of alkaline phosphatase activity ----
    GO:0010811positive regulation of cell-substrate adhesion ISS15754038


    NPNT for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPNT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPNT
    Search CenterWatch for drugs/clinical trials and news about NPNT 

    Transcripts
    for NPNT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPNT gene (6 alternative transcripts): 
    NM_198278.1  NM_001033047.2  NM_001184690.1  NM_001184691.1  NM_001184692.1  NM_001184693.1  

    Unigene Cluster for NPNT:

    Nephronectin
    Hs.518921  [show with all ESTs]
    Unigene Representative Sequence: NM_001184691
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504304 ENST00000379987(uc011cfc.2 uc011cfd.2 uc011cfe.2 uc003hya.3 uc011cff.2)
    ENST00000453617 ENST00000427316 ENST00000514622 ENST00000305572 ENST00000506666
    ENST00000503451 ENST00000514837 ENST00000513430 ENST00000506056 ENST00000511518
    ENST00000505821 ENST00000514632 ENST00000504787 ENST00000505917

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NPNT
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPNT
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NPNT (see all 59):
    hsa-miR-26a-2* hsa-miR-3607-3p hsa-miR-25 hsa-miR-301a hsa-miR-578 hsa-miR-570 hsa-miR-3142 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NPNT 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPNT (see all 4)
    OriGene shRNA RFP: NPNT
    OriGene siRNA: NPNT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPNT
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NPNT (NM_001033047)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPNT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPNT 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPNT
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPNT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPNT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPNT

    Additional cDNA sequence: 

    AK172856.1 AK290029.1 AK295772.1 AK302477.1 AK304279.1 AK304721.1 AL832465.1 AY358336.1 
    BC131587.1 

    14 DOTS entries:

    DT.121240583  DT.316804  DT.95360310  DT.121240617  DT.91749644  DT.100737977  DT.121240628  DT.121240638 
    DT.40244714  DT.101972739  DT.40222419  DT.75190830  DT.121240623  DT.91881057 

    24/131 AceView cDNA sequences (see all 131):

    AA977714 W32742 BF221551 AA633471 W79395 H88484 NM_198278 W79315 
    BU683331 BE046423 AW304247 BQ777622 AA448654 AW302459 AI129329 AA234382 
    AY358336 BQ188133 AI802522 BG152866 AI493079 BQ771593 AI417207 BQ017010 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NPNT (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
    SP1:                                -                 -     -     -                                                                                 
    SP2:                                -     -           -     -     -                                                                                 
    SP3:                                -     -           -     -                                                                                       
    SP4:                                -     -           -                                                                                             
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for NPNT

    Expression
    for NPNT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPNT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAAAGGTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPNT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Embryoid bodies (Two-step protocol fo...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

    See NPNT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPNT

    SOURCE GeneReport for Unigene cluster: Hs.518921

    UniProtKB/Swiss-Prot: NPNT_HUMAN, Q6UXI9
    Tissue specificity: Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid
    gland and blood vessels

        SABiosciences Custom PCR Arrays for NPNT
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPNT
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPNT
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPNT
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPNT
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPNT

    Orthologs
    for NPNT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPNT gene from 2/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NPNT1 nephronectin 74.18(n)
    71.85(a)    		   422535  XM_420498.3  XP_420498.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii npnt1 nephronectin 60.95(n)
    60.42(a)    		   563273  NM_001145580.1  NP_001139052.1 


    ENSEMBL Gene Tree for NPNT (if available)
    TreeFam Gene Tree for NPNT (if available) 

    Paralogs
    for NPNT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPNT gene
    EGFL82  EGFL62  EGFL72  ENSG000002583882  
    11 SIMAP similar genes for NPNT using alignment to 6 protein entries:     NPNT_HUMAN (see all proteins):
    NRP1    EGFL6    EFEMP2    EGF    FBN2    LTBP3
    LTBP2    FBLN2    HMCN1    LTBP4    PROS1

    NPNT for paralogs           About GeneDecksing



    Genomic Variants
    for NPNT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPNT
    DNA2.0 Custom Variant and Variant Library Synthesis for NPNT

    Disorders / Diseases
    for NPNT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPNT for disorders           About GeneDecksing

    OMIM gene information: 610306    OMIM disorders: --

    7 diseases for NPNT:    About MalaCards
    acute kidney tubular necrosis    renal agenesis    pulmonary function    alcohol dependence
    alcoholism    thyroiditis    melanoma

    Human Genome Epidemiology (HuGE) Navigator: NPNT (2 documents)

    Export disorders for NPNT gene to outside databases

    Publications
    for NPNT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPNT gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NPNT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human nephronectin gene in silico. (PubMed id 15754038)1, 2, 3, 9 Huang J.T.-J. and Lee V. (2005)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. MicroRNA miR-378 regulates nephronectin expression mo dulating osteoblast differentiation by targeting GalNT-7. (PubMed id 19844573)1, 9 Kahai S....Yang B.B. (2009)
    4. Proteome analysis of laser microdissected glomeruli fr om formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: n ephronectin is associated with the development of diabetic glomerulosclerosis. (PubMed id 22172726)1 Nakatani S....Wanibuchi H. (2012)
    5. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    6. Meta-analyses of genome-wide association studies iden tify multiple loci associated with pulmonary function. (PubMed id 20010835)1 Hancock D.B....London S.J. (2010)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. (PubMed id 11470831)1 Brandenberger R....Reichardt L.F. (2001)

    External Searches for NPNT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPNT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255743 HGNC: 27405 AceView: LOC255743 Ensembl:ENSG00000168743 euGenes: HUgn255743
    ECgene: NPNT H-InvDB: NPNT

    Other Databases showing NPNT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPNT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPNT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPNT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPNT gene:
    Search GeneIP for patents involving NPNT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NPNT gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NPNT (Nephronectin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NPNT  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPNT   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPNT  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NPNT   OriGene 3'-UTR Clone for NPNT  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPNT  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPNT   OriGene Custom Protein Services for NPNT  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPNT
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPNT
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPNT
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPNT
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPNT
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPNT
     GenScript Custom Purified and Recombinant Proteins Services for NPNT GenScript cDNA clones with any tag delivered in your preferred vector for NPNT
     GenScript Custom Assay Services for NPNT GenScript Custom Superior Antibodies Services for NPNT
     GenScript Custom overexpressing Cell Line Services for NPNT CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NPNT promoter
     Search Chromatin IP Primers for NPNT
     RT2 qPCR Primer Assay in human, mouse, rat NPNT
     Search GNC Networks for NPNT
     SABiosciences Custom PCR Arrays for NPNT
     Search Tocris compounds for NPNT
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPNT antibodies
     Search for Antibodies for NPNT at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NPNT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NPNT Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NPNT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPNT
     SwitchGear 3'UTR luciferase reporter plasmids for NPNT
     SwitchGear Promoter luciferase reporter plasmids for NPNT
     Search ThermoFisher Antibodies for NPNT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPNT
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NPNT gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4