NPM3 Gene
protein-coding GIFtS: 51
GCID: GC10M103532
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nucleophosmin/nucleoplasmin 3
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Aliases
for NPM3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleophosmin/Nucleoplasmin 31 2 | | PORMIN2 | | TMEM1232 | | Nucleophosmin/Nucleoplasmin Family, Member 32 | | Nucleoplasmin-31 |
Export aliases for NPM3 gene to outside databasesPrevious GC identifers: GC10M102434 GC10M102774 GC10M103672 GC10M103205 GC10M097171 |
Summaries
for NPM3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NPM3:
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin.This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on itssimilarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cellnucleus. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607Function: May act as a chaperone
Gene Wiki entry for NPM3
|
Genomic Views
for NPM3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPM3 gene promoter:
MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPM3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPM3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.31 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.31NPM3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M103532: view genomic region
(about GC identifiers)
Start:
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103,541,082 bp from pter |
End:
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103,543,170 bp from pter |
Size:
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2,089 bases |
Orientation:
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minus strand |
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Proteins
for NPM3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607 (See
protein sequence)Recommended Name: Nucleoplasmin-3 Size: 178 amino acids; 19344 Da
Subcellular location: Nucleus
Secondary accessions: Q9UNY6Explore the universe of human proteins at neXtProt for NPM3: NX_O75607
Post-translational modifications:
Phosphorylated (Potential)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75607
NPM3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008924.1
ENSEMBL proteins: ENSP00000359128
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
NPM3 for ontologies About GeneDecksing
NPM3 Antibody Products:
Assay Products for NPM3: |
Protein
Domains /
Families
for NPM3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPM3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75607ProtoNet protein and cluster: O75607 1 Blocks protein family: IPB004301 Nucleoplasmin
UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607Similarity: Belongs to the nucleoplasmin family |
Function
for NPM3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607Function: May act as a chaperone
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NPM3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
NPM3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NPM3:
|
Pathways & Interactions
for NPM3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPM3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/8 Interacting proteins for NPM3 (O756071, 2, 3 ENSP000003591284) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- | | GO:0009303 | rRNA transcription |
IEA | -- |
NPM3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NPM3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPM3
Search CenterWatch for drugs/clinical trials and news about NPM3
|
Transcripts
for NPM3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPM3 gene: NM_006993.2 Unigene Cluster for NPM3: Nucleophosmin/nucleoplasmin 3 Hs.90691 [show with all ESTs]Unigene Representative Sequence: BM5561304 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370110(uc001ktt.3) ENST00000474993 ENST00000462391 ENST00000468544
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPM3 (NM_006993) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPM3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM3 |
Additional cDNA sequence: AF081280.1 AY049737.1 BC041067.1 BC054868.1 3 DOTS entries: DT.441173 DT.121287029 DT.95370108 24/88 AceView cDNA sequences (see all 88): CR621461 BM803992 CD246911 BM765409 BM739560 AI015740 CR601718 BP338788 BF224446 BI760860 AI341859 BF337404 BQ008658 BC041067 BE856560 BM830903 AI631542 BQ435348 BU633413 BC054868 BM739536 BM556130 BM811034 CR603429
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NPM3 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
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| SP1: | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NPM3
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Expression
for NPM3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGGGGCCT
About this image
See NPM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPM3
SOURCE GeneReport for Unigene cluster: Hs.90691
UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for NPM3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPM3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NPM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM3 |
Orthologs
for NPM3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NPM3 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for NPM3 (if available)
TreeFam Gene Tree for NPM3 (if available) |
Paralogs
for NPM3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NPM3 gene
- NPM22 NPM12
2 SIMAP similar genes for NPM3 using alignment to 1 protein entry: NPM3_HUMAN:NPM1 NPM2
NPM3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NPM3
PGOHUM00000242797
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Genomic Variants
for NPM3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPM3 (103541082 - 103543170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NPM3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPM3 |
|
Disorders
/ Diseases
for NPM3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPM3 for disorders About GeneDecksing
OMIM gene information: 606456
OMIM disorders: --
2  diseases for NPM3: About MalaCardsmyxoid liposarcoma liposarcoma
Export disorders for NPM3 gene to outside databases
|
Publications
for NPM3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPM3 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with NPM3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones. (PubMed id 11722795)1, 2, 3, 9 Shackleford G.M.... MacArthur C.A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Function of homo- and hetero-oligomers of human nucleo plasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. (PubMed id 22362753)1 Okuwaki M....Nagata K. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
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External Searches for NPM3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPM3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPM3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPM3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPM3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPM3 gene:
Search GeneIP for patents involving NPM3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPM3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPM3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPM3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPM3 | | | OriGene Protein Over-expression Lysate for NPM3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPM3 | | OriGene 3'-UTR Clone for NPM3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPM3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NPM3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPM3 | | OriGene Custom Protein Services for NPM3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPM3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPM3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPM3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPM3 |
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 |  |  |  | |
| | | | Search Tocris compounds for NPM3 |
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 | | | NPM3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM3 |
|  |  |  | | | | ThermoFisher Antibodies for NPM3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM3 |
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