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NPM3 Gene

protein-coding   GIFtS: 55
GCID: GC10M103532

Nucleophosmin/Nucleoplasmin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleophosmin/Nucleoplasmin 31 2
PORMIN2
TMEM1232
Nucleophosmin/Nucleoplasmin Family, Member 32
nucleoplasmin-32

External Ids:    HGNC: 79311   Entrez Gene: 103602   Ensembl: ENSG000001078337   OMIM: 6064565   UniProtKB: O756073   

Export aliases for NPM3 gene to outside databases

Previous GC identifers: GC10M102434 GC10M102774 GC10M103672 GC10M103205 GC10M097171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPM3 Gene:
The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and
nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the
nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular
chaperone in the cell nucleus. (provided by RefSeq, Oct 2008)

GeneCards Summary for NPM3 Gene:
NPM3 (nucleophosmin/nucleoplasmin 3) is a protein-coding gene. Diseases associated with NPM3 include myxoid liposarcoma, and extraskeletal myxoid chondrosarcoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is NPM2.

UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607
Function: May act as a chaperone

Gene Wiki entry for NPM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPM3 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPM3 promoter sequence
   Search Chromatin IP Primers for NPM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.31

NPM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPM3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103532:  view genomic region     (about GC identifiers)

Start:
103,541,082 bp from pter      End:
103,543,170 bp from pter
Size:
2,089 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607 (See protein sequence)
Recommended Name: Nucleoplasmin-3  
Size: 178 amino acids; 19344 Da
Secondary accessions: Q9UNY6

Explore the universe of human proteins at neXtProt for NPM3: NX_O75607

Explore proteomics data for NPM3 at MOPED

Post-translational modifications: 

  • Phosphorylated (Potential)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NPM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008924.1  
    ENSEMBL proteins: 
     ENSP00000359128  

    NPM3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for NPM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024057 Nucleoplasmin_core_dom
     IPR004301 Nucleoplasmin

    Graphical View of Domain Structure for InterPro Entry O75607

    ProtoNet protein and cluster: O75607

    1 Blocks protein domain: IPB004301 Nucleoplasmin

    UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607
    Similarity: Belongs to the nucleoplasmin family


    NPM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPM3_HUMAN, O75607
    Function: May act as a chaperone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    NPM3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPM3:
     Decreased melanin production 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPM3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPM3

    miRNA
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    miRTarBase miRNAs that target NPM3:
    hsa-mir-99a-5p (MIRT048670), hsa-mir-124-3p (MIRT022521)

    Block miRNA regulation of human, mouse, rat NPM3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NPM3:
    hsa-miR-877* hsa-miR-205* hsa-miR-548c-3p hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidNPM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NPM3
    Predesigned siRNA for gene silencing in human, mouse, rat NPM3

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    GenScript: all cDNA clones in your preferred vector: NPM3 (NM_006993)
    Sino Biological Human cDNA Clone for NPM3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPM3_HUMAN, O75607: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    NPM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPM3
    Interactions:

        Search GeneGlobe Interaction Network for NPM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for NPM3 (O756071, 2, 3 ENSP000003591284) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WT1P195442, 3, ENSP000003313274MINT-8277141 I2D: score=2 STRING: ENSP00000331327
    KIAA1377Q9P2H02, 3MINT-63220 I2D: score=5 
    NPM1P067483, ENSP000002969304I2D: score=1 STRING: ENSP00000296930
    WIPI2Q9Y4P83I2D: score=1 
    NCLENSP000003181954STRING: ENSP00000318195
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0009303rRNA transcription IEA--

    NPM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPM3 gene: 
    NM_006993.2  

    Unigene Cluster for NPM3:

    Nucleophosmin/nucleoplasmin 3
    Hs.90691  [show with all ESTs]
    Unigene Representative Sequence: BM556130
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370110(uc001ktt.3) ENST00000474993 ENST00000462391 ENST00000468544

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate NPM3:
    hsa-miR-877* hsa-miR-205* hsa-miR-548c-3p hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidNPM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NPM3
    Predesigned siRNA for gene silencing in human, mouse, rat NPM3
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    GenScript: all cDNA clones in your preferred vector: NPM3 (NM_006993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM3
    Primer
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    OriGene qPCR primer pairs and template standards for NPM3
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      QuantiTect SYBR Green Assays in human, mouse, rat NPM3
      QuantiFast Probe-based Assays in human, mouse, rat NPM3

    Additional mRNA sequence: 

    AF081280.1 AY049737.1 BC041067.1 BC054868.1 

    3 DOTS entries:

    DT.441173  DT.121287029  DT.95370108 

    Selected AceView cDNA sequences (see all 88):

    CD246911 AI341859 AI015740 CR621461 BC054868 BU633413 BI760860 CR601718 
    BF337404 BE856560 BP338788 BQ008658 BM739560 BM811034 BF224446 BM830903 
    AI631542 BQ435348 BM803992 CR603429 BM765409 BC041067 BM739536 BM556130 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NPM3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
    SP1:                          -                                 
    SP2:                    -     -                                 
    SP3:                          -           -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for NPM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGGGGCCT
    NPM3 Expression
    About this image


    NPM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    NPM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90691

    UniProtKB/Swiss-Prot: NPM3_HUMAN, O75607
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for NPM3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPM3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npm31 , 5 nucleoplasmin 31, 5 82.29(n)1
    84(a)1
      19 (38.75 cM)5
    181501  NM_008723.11  NP_032749.11 
     457477345 
    chicken
    (Gallus gallus)
    Aves NPM31 nucleophosmin/nucleoplasmin 3 67.88(n)
    64.23(a)
      770430  XM_001233763.3  XP_001233764.2 
    lizard
    (Anolis carolinensis)
    Reptilia NPM36
    nucleophosmin/nucleoplasmin 3
    56(a)
    1 ↔ 1
    GL343239.1(1305224-1313329)
    zebrafish
    (Danio rerio)
    Actinopterygii npm1b6
    nucleophosmin/nucleoplasmin, 1b
    17(a)
    many ↔ many
    14(5594201-5648591) ENSDARG00000037675


    ENSEMBL Gene Tree for NPM3 (if available)
    TreeFam Gene Tree for NPM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPM3 gene
    NPM22  NPM12  
    2 SIMAP similar genes for NPM3 using alignment to 1 protein entry:     NPM3_HUMAN:
    NPM1    NPM2

    NPM3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NPM3
    PGOHUM00000242797


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPM3 (see all 61)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25928351,2
    C,F,H--103542312(-) TGGTAG/AAAGTT 2 /K /E mis19Minor allele frequency- A:0.01NS EA NA 852
    rs27354201,2,,4
    H--103542320(-) GTGTAA/TTGTGG 2 N I mis16Minor allele frequency- T:0.00NS EA NA 408
    rs750020761,2
    C--103542409(+) CCACAA/GCTAAA 1 -- int12Minor allele frequency- G:0.00WA EU 1029
    rs1997194391,2
    C--103542583(+) CACTCC/GCCTGC 1 -- int10--------
    rs25928341,2
    H--103542616(-) CGGAGC/GACGTG 2 H D mis1 ese34Minor allele frequency- G:0.00NS EA 404
    rs2011359871,2
    C--103542667(+) GTGGCC/TGGAGA 2 S G mis11Minor allele frequency- T:0.00EU 1281
    rs27354181,2
    C--103542732(-) CCCCGC/TTGCCC 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1929002301,2
    --103542768(+) TAACCC/TTGGGC 1 -- int10--------
    rs1478496961,2
    --103542773(+) TTGGGC/GGGACG 1 -- int10--------
    rs1845503021,2
    --103542910(+) CTCCTA/GCGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NPM3 (103541082 - 103543170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NPM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv171n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPM3
    DNA2.0 Custom Variant and Variant Library Synthesis for NPM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606456    OMIM disorders: --

    5 diseases for NPM3:    
    About MalaCards
    myxoid liposarcoma    extraskeletal myxoid chondrosarcoma    liposarcoma    myxoid chondrosarcoma
    chondrosarcoma

    1 disease from the University of Copenhagen DISEASES database for NPM3:
    Extraskeletal myxoid chondrosarcoma

    NPM3 for disorders           About GeneDecksing


    Export disorders for NPM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPM3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NPM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones. (PubMed id 11722795)1, 2, 3, 9 Shackleford G.M.... MacArthur C.A. (BMC Genomics 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    6. Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. (PubMed id 22362753)1 Okuwaki M....Nagata K. (Nucleic Acids Res. 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities. (PubMed id 22968912)1 Finn R.M....AusiA^ J. (FASEB J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10360 HGNC: 7931 AceView: NPM3 Ensembl:ENSG00000107833 euGenes: HUgn10360
    ECgene: NPM3 H-InvDB: NPM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPM3 gene:
    Search GeneIP for patents involving NPM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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