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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NPM2 Gene

protein-coding GIFtS: 48
GCID: GC08P021881

nucleophosmin/nucleoplasmin 2

Explore 2 diseases affiliated with
NPM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleophosmin/Nucleoplasmin 2¹ ²
Nucleoplasmin-2¹

External Ids:	HGNC: 7930¹	Entrez Gene: 10361²	Ensembl: ENSG00000158806⁷	OMIM: 608073⁵	UniProtKB: Q86SE8³

Export aliases for NPM2 gene to outside databases

Previous GC identifers: GC00U990477 GC08U900224 GC08P021903 GC08P021904 GC08P021939 GC08P020424

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NPM2_HUMAN, Q86SE8

Function: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early

embryonic development. Probably involved in sperm DNA decondensation during fertilization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NPM2 gene promoter:
HFH-3 FOXD3 GATA-1 FOXL1 Evi-1 FOXI1 FOXJ2 (long isoform) HFH-1 FOXJ2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPM2 promoter sequence

Search SABiosciences Chromatin IP Primers for NPM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.3

NPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPM2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P021881: view genomic region (about GC identifiers)

Start:	21,881,636 bp from pter	End:	21,894,408 bp from pter
Size:	12,773 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NPM2_HUMAN, Q86SE8 (See protein sequence)

Recommended Name: Nucleoplasmin-2

Size: 214 amino acids; 24152 Da

Subunit: Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B

dimers and H3-H4 tetramers simultaneously

Subcellular location: Nucleus (By similarity). Note=Found in the oocyte nucleus before nuclear membrane breakdown,

after which it is redistributed to the cytoplasm (By similarity)

1 PDB 3D structure from and Proteopedia for NPM2:

3T30 (3D)

Secondary accessions: B3KSU0 D3DSQ8

Explore the universe of human proteins at neXtProt for NPM2: NX_Q86SE8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86SE8

NPM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_877724.1

ENSEMBL proteins:

ENSP00000429984 ENSP00000429413 ENSP00000381032 ENSP00000428016 ENSP00000427741

ENSP00000289820 ENSP00000370941

Human Recombinant Protein Products for NPM2:

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	Uscn Proteins for NPM2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000789	cytoplasmic chromatin	IDA	12714744
GO:0000790	nuclear chromatin	IDA	12714744
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

NPM2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NPM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NPM2 for domains About GeneDecksing

2 InterPro domains/families:

IPR024057 Nucleoplasmin_core

IPR004301 Nucleoplasmin

Graphical View of Domain Structure for InterPro Entry Q86SE8

ProtoNet protein and cluster: Q86SE8

1 Blocks protein family: IPB004301 Nucleoplasmin

UniProtKB/Swiss-Prot: NPM2_HUMAN, Q86SE8

Domain: The acidic tract A2 mediates histone binding

Similarity: Belongs to the nucleoplasmin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NPM2_HUMAN, Q86SE8

Function: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early

embryonic development. Probably involved in sperm DNA decondensation during fertilization

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0019899	enzyme binding	IEA	--
GO:0042393	histone binding	TAS	12581654

NPM2 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Npm2):

embryogenesis

reproductive system

NPM2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Npm2^tm1Zuk for NPM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NPM2

miRNA Products:		OriGene 3'-UTR Clone: NPM2 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NPM2

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006338	chromatin remodeling	IDA	12714744
GO:0007096	regulation of exit from mitosis	IMP	12714744
GO:0007338	single fertilization	IMP	12714744
GO:0009790	embryo development	IMP	12714744
GO:0009994	oocyte differentiation	IEP	12714744

NPM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPM2
Search CenterWatch for drugs/clinical trials and news about NPM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NPM2 gene:

NM_182795.1

Unigene Cluster for NPM2:

Nucleophosmin/nucleoplasmin 2

Hs.131055 [show with all ESTs]

Unigene Representative Sequence: AK127602

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520125 ENST00000521157 ENST00000397940(uc003xac.3 uc003xad.3)

ENST00000522813 ENST00000518119 ENST00000520180 ENST00000289820(uc003xae.3 uc003xaf.3)

ENST00000381530 ENST00000522953 ENST00000520456 ENST00000519373 ENST00000524322

miRNA Products:		OriGene 3'-UTR Clone: NPM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPM2
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		SwitchGear 3'UTR luciferase reporter plasmid: NPM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NPM2 (NM_182795)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM2

Additional cDNA sequence:

AK094267.1 AK127602.1 AY262113.1 AY262114.1 BC068078.1

7 DOTS entries:

DT.301347 DT.100744955 DT.95265579 DT.100021410 DT.121484015 DT.121484020 DT.121484021

24/33 AceView cDNA sequences (see all 33):

BI913169 CK904862 BC068078 BQ684424 BQ878692 AY262114 BF594409 AI391464

BM055230 AY262113 BQ684634 AK094267 NM_182795 CR603169 BU155917 BI439005

AW002370 AI016313 BF057162 BQ878312 BI914922 BX422822 BF592761 BQ682257

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NPM2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:											-		-
SP2:
SP3:
SP4:																							-		-
SP5:					-						-		-

ECgene alternative splicing isoforms for NPM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NPM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACGCACA

About this image

NPM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See NPM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPM2

SOURCE GeneReport for Unigene cluster: Hs.131055

SABiosciences Custom PCR Arrays for NPM2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NPM2 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	NPM2⁶	--	33(a)	1 ↔ 1	GL343322.1(721342-727981)
African clawed frog (Xenopus laevis)	Amphibia	npm-A²	nucleoplasmin	71.1(n)		X04766.1
zebrafish (Danio rerio)	Actinopterygii	npm2¹	nucleoplasmin 2	52.41(n) 43.89(a)		555786 NM_001123007.2 NP_001116479.2

ENSEMBL Gene Tree for NPM2 (if available)
TreeFam Gene Tree for NPM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NPM2 gene

NPM3² NPM1²

2 SIMAP similar genes for NPM2 using alignment to 4 protein entries: NPM2_HUMAN (see all proteins):

NPM3 NPM1

NPM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191333261^1,2		--	21880454(+)	`CACTTC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs184287831^1,2		--	21880539(+)	`AAAAAC/TATGAA`	1	--	us2k¹		0	--	--	--	--
rs145483292^1,2		--	21880582(+)	`ACCCAA/GCTACT`	1	--	us2k¹		0	--	--	--	--
rs151030162^1,2		--	21880615(+)	`CGCTTC/GAACAT`	1	--	us2k¹		0	--	--	--	--
rs116904664^1,2	F	--	21880642(+)	`AGTGAG/CCTGAG`	1	--	us2k¹		2		NA EA	240
rs146188614^1,2	C	--	21880658(+)	`CCACC-/GCA CTCCAGCACT`	1	--	us2k¹		0	--	--	--	--
rs188221125^1,2		--	21880716(+)	`AAAGAA/GAAGAA`	1	--	us2k¹		0	--	--	--	--
rs2957336^1,2	C,H	--	21880725(-)	`CAACAT/ATATTT`	1	--	us2k¹		4		NS EA	396
rs55798233^1,2	C,F	--	21880741(+)	`ACCCCA/CGTTAC`	1	--	us2k¹		1		NA	120
rs192993133^1,2		--	21880823(+)	`ATATGC/TATCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NPM2 (21881636 - 21894408 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NPM2
3 CNVs: 2746 3726 4586

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPM2

DNA2.0 Custom Variant and Variant Library Synthesis for NPM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NPM2 for disorders           About GeneDecksing

OMIM gene information: 608073    OMIM disorders: --

2 diseases for NPM2:    About MalaCards

breast cancer melanoma

Human Genome Epidemiology (HuGE) Navigator: NPM2 (1 document)

Export disorders for NPM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NPM2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NPM2)

Utopia: connect your pdf to the dynamic
world of online information

Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. (PubMed id 12714744)^{1, 2, 3} Burns K.H.... Matzuk M.M. (2003)
Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. (PubMed id 21863821)^{1, 2} Platonova O.... Akey C.W. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones. (PubMed id 17187372)^{2, 9} Frehlick L.J....Ausio J. (2007)
Function of homo- and hetero-oligomers of human nucleo plasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. (PubMed id 22362753)¹ Okuwaki M....Nagata K. (2012)
Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)¹ Olson J.E....Couch F.J. (2010)
Genome-wide screen of promoter methylation identifies novel markers in melanoma. (PubMed id 19491193)¹ Koga Y....Weissman S.M. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Histone chaperones and nucleosome assembly. (PubMed id 12581654)¹ Akey C.W. and Luger K. (2003)
Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells. (PubMed id 12209603)¹ Dalenc F....Toulas C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10361	HGNC: 7930	AceView: NPM2	Ensembl:ENSG00000158806	euGenes: HUgn10361
ECgene: NPM2	H-InvDB: NPM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NPM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NPM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NPM2 gene:
Search GeneIP for patents involving NPM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for NPM2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPM2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPM2
	OriGene Protein Over-expression Lysate for NPM2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NPM2		OriGene 3'-UTR Clone for NPM2
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	OriGene Custom Antibody Services for NPM2		OriGene Custom Protein Services for NPM2
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPM2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPM2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPM2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPM2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPM2

	GenScript Custom Purified and Recombinant Proteins Services for NPM2		GenScript cDNA clones with any tag delivered in your preferred vector for NPM2
	GenScript Custom Assay Services for NPM2		GenScript Custom Superior Antibodies Services for NPM2
	GenScript Custom overexpressing Cell Line Services for NPM2		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Recombinant Protein for NPM2

NPM2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NPM2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPM2

	SwitchGear 3'UTR luciferase reporter plasmids for NPM2
	SwitchGear Promoter luciferase reporter plasmids for NPM2

Search ThermoFisher Antibodies for NPM2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NPM2

Sirion Biotech Customized:

	stable knockdown cell line services for NPM2
	inducible knockdown cell line services for NPM2
	design and validation of potent shRNA sequences against NPM2
	adenovirus for potent knockdown of NPM2
	adenovirus for overexpression of NPM2
	stable overexpressing cell line services for NPM2
	inducible overexpressing cell line services for NPM2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NPM2 gene at Home site.

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NPM2 Gene

nucleophosmin/nucleoplasmin 2

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NPM2 Gene

nucleophosmin/nucleoplasmin 2

Aliasesfor NPM2 gene

Summariesfor NPM2 gene

Genomic Viewsfor NPM2 gene

Proteinsfor NPM2 gene

Protein Domains /Familiesfor NPM2 gene

Functionfor NPM2 gene

Pathways & Interactionsfor NPM2 gene

Drugs & Compoundsfor NPM2 gene

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Genome Databases showing NPM2 gene

Other Databases showing NPM2 gene

Specialized Databases showing NPM2 gene

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Aliases
for NPM2 gene

Summaries
for NPM2 gene

Genomic Views
for NPM2 gene

Proteins
for NPM2 gene

Protein Domains /
Families
for NPM2 gene

Function
for NPM2 gene

Pathways & Interactions
for NPM2 gene

Drugs & Compounds
for NPM2 gene

Transcripts
for NPM2 gene

Expression
for NPM2 gene

Orthologs
for NPM2 gene

Paralogs
for NPM2 gene

Genomic Variants
for NPM2 gene

Disorders / Diseases
for NPM2 gene

Publications
for NPM2 gene

Intellectual Property
for NPM2 gene

Products
for NPM2 gene