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Aliases for NPM1 Gene

Aliases for NPM1 Gene

  • Nucleophosmin 2 3 3 5
  • Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin) 2 3
  • Nucleophosmin/Nucleoplasmin Family, Member 1 2 3
  • Nucleolar Phosphoprotein B23 2 4
  • Nucleolar Protein NO38 3 4
  • Numatrin 2 4
  • NPM 3 4
  • Testicular Tissue Protein Li 128 3
  • B23 3

External Ids for NPM1 Gene

Previous GeneCards Identifiers for NPM1 Gene

  • GC05P171050
  • GC05P171517
  • GC05P170750
  • GC05P170795
  • GC05P170746
  • GC05P170747
  • GC05P170814
  • GC05P165912

Summaries for NPM1 Gene

Entrez Gene Summary for NPM1 Gene

  • This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

GeneCards Summary for NPM1 Gene

NPM1 (Nucleophosmin) is a Protein Coding gene. Diseases associated with NPM1 include Leukemia, Acute Myeloid and Lymphomatoid Papulosis. Among its related pathways are Transport of the SLBP independent Mature mRNA and HIV Life Cycle. GO annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is NPM2.

UniProtKB/Swiss-Prot for NPM1 Gene

  • Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486).

Gene Wiki entry for NPM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPM1 Gene

Genomics for NPM1 Gene

Regulatory Elements for NPM1 Gene

Enhancers for NPM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F172274 1.5 FANTOM5 Ensembl ENCODE 35.5 +888.6 888599 2.6 PKNOX1 KLF17 THRB BRCA1 ZEB1 ZNF366 CBX5 ZNF143 RCOR1 ZNF548 NPM1 SH3PXD2B UBTD2 CREBRF EFCAB9 ENSG00000212529 RPL10P8 STK10 DUSP1 KLF3P1
GH05F172004 1.3 FANTOM5 Ensembl ENCODE 25.7 +620.2 620246 5.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 NPM1 UBTD2 NEURL1B STK10 FBXW11 GC05P172013
GH05F172353 0.2 ENCODE 22.2 +967.4 967433 2.5 PKNOX1 ZFP64 ARID4B FEZF1 ZNF48 ZNF2 GLIS2 ELK1 KLF7 ZNF548 NPM1 SH3PXD2B UBTD2 CREBRF DUSP1 PIR48158 PIR48190
GH05F172360 1.4 FANTOM5 Ensembl ENCODE 21.6 +974.8 974843 2.3 TBP SIN3A ZNF366 SCRT2 FOS ZNF548 CREM USF2 CEBPB JUNB SH3PXD2B NPM1 UBTD2 CREBRF STK10 DUSP1 PIR48158 PIR48190
GH05F170484 0.2 Ensembl 15.2 -901.9 -901857 1.2 HDGF CTCF FEZF1 ZIC2 RAD21 ZNF121 ZNF791 ZNF366 ZNF157 SCRT1 NPM1 RPL10P8 ENSG00000253858 KCNMB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NPM1 on UCSC Golden Path with GeneCards custom track

Promoters for NPM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001296554 1384 3801 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS

Genomic Location for NPM1 Gene

Chromosome:
5
Start:
171,387,116 bp from pter
End:
171,411,137 bp from pter
Size:
24,022 bases
Orientation:
Plus strand

Genomic View for NPM1 Gene

Genes around NPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPM1 Gene

Proteins for NPM1 Gene

  • Protein details for NPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06748-NPM_HUMAN
    Recommended name:
    Nucleophosmin
    Protein Accession:
    P06748
    Secondary Accessions:
    • A8K3N7
    • B5BU00
    • D3DQL6
    • P08693
    • Q12826
    • Q13440
    • Q13441
    • Q14115
    • Q5EU94
    • Q5EU95
    • Q5EU96
    • Q5EU97
    • Q5EU98
    • Q5EU99
    • Q6V962
    • Q8WTW5
    • Q96AT6
    • Q96DC4
    • Q96EA5
    • Q9BYG9
    • Q9UDJ7

    Protein attributes for NPM1 Gene

    Size:
    294 amino acids
    Molecular mass:
    32575 Da
    Quaternary structure:
    • Decamer formed by two pentameric rings associated in a head-to-head fashion. Disulfide-linked dimers under certain conditions. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2 and SENP3. Interacts with hepatitis delta virus S-HDAg. Interacts with HTLV1 Rex protein (via N-terminal nuclear localization signal). Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts with isoform 1 of NEK2. Interacts with ROCK2 and BRCA2. Interacts with RPGR. Interacts with CENPW. Interacts with EIF2AK2/PKR. Interacts with CEBPA (isoform 4) (PubMed:20075868). Interacts with DDX31; this interaction prevents interaction between NPM1 and HDM2 (PubMed:23019224).

    Three dimensional structures from OCA and Proteopedia for NPM1 Gene

    Alternative splice isoforms for NPM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPM1 Gene

Post-translational modifications for NPM1 Gene

  • Acetylated at C-terminal lysine residues, thereby increasing affinity to histones.
  • ADP-ribosylated.
  • Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at Thr-199 may trigger initiation of centrosome duplication. Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis. When these four sites are phosphorated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2. The Thr-199 phosphorylated form has higher affinity for ROCK2. CDK6 triggers Thr-199 phosphorylation when complexed to Kaposis sarcoma herpesvirus (KSHV) V-cyclin, leading to viral reactivation by reducing viral LANA levels.
  • Sumoylated by ARF.
  • Ubiquitination at Lys 27, Lys 80, Lys 250, and Lys 273
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPM1 Gene

Domains & Families for NPM1 Gene

Protein Domains for NPM1 Gene

Suggested Antigen Peptide Sequences for NPM1 Gene

Graphical View of Domain Structure for InterPro Entry

P06748

UniProtKB/Swiss-Prot:

NPM_HUMAN :
  • Belongs to the nucleoplasmin family.
Family:
  • Belongs to the nucleoplasmin family.
genes like me logo Genes that share domains with NPM1: view

No data available for Gene Families for NPM1 Gene

Function for NPM1 Gene

Molecular function for NPM1 Gene

GENATLAS Biochemistry:
nucleophosmin,interferon 1 (IRF1) binding protein,involved in anaplastic nodal non Hodgkin lymphoma and B cell lymphoma with translocation t(2;5)(p23;q35),see ALK,and in acute promyelocytic leukemia with translocation t(5;17) and myelodysplastic syndrome
UniProtKB/Swiss-Prot Function:
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486).

Gene Ontology (GO) - Molecular Function for NPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 15087454
GO:0003723 RNA binding IEA,IDA 12058066
GO:0004860 protein kinase inhibitor activity IDA 12882984
GO:0005515 protein binding IPI 12080348
GO:0019901 protein kinase binding IPI 20352051
genes like me logo Genes that share ontologies with NPM1: view
genes like me logo Genes that share phenotypes with NPM1: view

Human Phenotype Ontology for NPM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NPM1 Gene

MGI Knock Outs for NPM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPM1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NPM1 Gene

Localization for NPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPM1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPM1 Gene COMPARTMENTS Subcellular localization image for NPM1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IEA,TAS --
GO:0005730 nucleolus IEA,IDA 11420665
GO:0005737 cytoplasm ISS --
GO:0005813 centrosome ISS --
genes like me logo Genes that share ontologies with NPM1: view

Pathways & Interactions for NPM1 Gene

genes like me logo Genes that share pathways with NPM1: view

SIGNOR curated interactions for NPM1 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for NPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IDA 19188445
GO:0006334 nucleosome assembly IDA 11602260
GO:0006886 intracellular protein transport TAS 12080348
GO:0006913 nucleocytoplasmic transport TAS 12080348
GO:0006950 response to stress IMP 12080348
genes like me logo Genes that share ontologies with NPM1: view

Drugs & Compounds for NPM1 Gene

(20) Drugs for NPM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(24) Additional Compounds for NPM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NPM1: view

Transcripts for NPM1 Gene

Unigene Clusters for NPM1 Gene

Nucleophosmin (nucleolar phosphoprotein B23, numatrin):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2:
SP3: - - - - - - - - - - -
SP4:
SP5: -
SP6: -

Relevant External Links for NPM1 Gene

GeneLoc Exon Structure for
NPM1
ECgene alternative splicing isoforms for
NPM1

Expression for NPM1 Gene

mRNA expression in normal human tissues for NPM1 Gene

Protein differential expression in normal tissues from HIPED for NPM1 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPM1 Gene



Protein tissue co-expression partners for NPM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPM1 Gene:

NPM1

SOURCE GeneReport for Unigene cluster for NPM1 Gene:

Hs.557550
genes like me logo Genes that share expression patterns with NPM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NPM1 Gene

Orthologs for NPM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPM1 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia NPM1 34 35
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 93 (a)
OneToMany
NPM1 34 35
  • 92.72 (n)
mouse
(Mus musculus)
Mammalia Gm5611 35
  • 92 (a)
OneToMany
Npm1 34 16
  • 91.1 (n)
rat
(Rattus norvegicus)
Mammalia Npm1 34
  • 91.1 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 88 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NPM1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPM1 34 35
  • 71.84 (n)
lizard
(Anolis carolinensis)
Reptilia NPM1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npm1 34
  • 67.12 (n)
MGC75688 34
zebrafish
(Danio rerio)
Actinopterygii npm1a 34 35
  • 59.31 (n)
Species where no ortholog for NPM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPM1 Gene

ENSEMBL:
Gene Tree for NPM1 (if available)
TreeFam:
Gene Tree for NPM1 (if available)

Paralogs for NPM1 Gene

Paralogs for NPM1 Gene

(3) SIMAP similar genes for NPM1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NPM1: view

Variants for NPM1 Gene

Sequence variations from dbSNP and Humsavar for NPM1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs587776806 Pathogenic 171,410,543(+) CTCTG(-/CATG/CCTG/CGTG/TCTG)GCAGT nc-transcript-variant, reference, frameshift-variant
rs375558588 untested 171,392,785(+) GCGGT(C/G)TGCCC nc-transcript-variant, reference, missense
rs587777962 untested 171,387,948(+) CACCC(C/G/T)ATGGA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs587778580 untested 171,392,719(+) GGAGG(A/G)AGATG nc-transcript-variant, reference, missense
rs587778581 untested 171,392,928(+) AAACT(-/TGC)TGCTG nc-transcript-variant, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for NPM1 Gene

Variant ID Type Subtype PubMed ID
nsv508387 CNV deletion 20534489
nsv823347 CNV gain 20364138
nsv830551 CNV loss 17160897
nsv830552 CNV gain 17160897
nsv968270 CNV duplication 23825009
nsv980752 CNV duplication 23825009

Variation tolerance for NPM1 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPM1 Gene

Human Gene Mutation Database (HGMD)
NPM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPM1 Gene

Disorders for NPM1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for NPM1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
lymphomatoid papulosis
  • lyp
primary cutaneous anaplastic large cell lymphoma
  • primary c-alcl
acute myeloblastic leukemia without maturation
  • acute myeloblastic leukemia m1
acute myeloid leukemia with npm1 somatic mutations
  • aml with npm1 somatic mutations
- elite association - COSMIC cancer census association via MalaCards
Search NPM1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NPM_HUMAN
  • Note=A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1. {ECO:0000269 PubMed:8570204}.
  • Note=A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA. {ECO:0000269 PubMed:8562957}.
  • Note=A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. {ECO:0000269 PubMed:8122112, ECO:0000269 PubMed:8633037}.
  • Note=Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. {ECO:0000269 PubMed:15659725}.

Genatlas disease for NPM1 Gene

acute promyelocytic leukemia (APL) gene fused with RARA in t(5;17) translocation (see RARA)

Relevant External Links for NPM1

Genetic Association Database (GAD)
NPM1
Human Genome Epidemiology (HuGE) Navigator
NPM1
Tumor Gene Database (TGDB):
NPM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPM1
genes like me logo Genes that share disorders with NPM1: view

Publications for NPM1 Gene

  1. Cytoplasmic expression of nucleophosmin accurately predicts mutation in the nucleophosmin gene in patients with acute myeloid leukemia and normal karyotype. (PMID: 20023256) Luo J. … Chang H. (Am. J. Clin. Pathol. 2010) 3 22 46 64
  2. Nucleophosmin mutations in Chinese adults with acute myelogenous leukemia. (PMID: 18726096) Ruan G.R. … Huang X.J. (Ann. Hematol. 2009) 3 22 46 64
  3. Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (PMID: 19637342) Konoplev S. … Bueso-Ramos C.E. (Cancer 2009) 3 22 46 64
  4. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PMID: 19188445) Vascotto C. … Tell G. (Mol. Cell. Biol. 2009) 3 4 22 64
  5. Mutations of NPM1 gene in de novo acute myeloid leukaemia: determination of incidence, distribution pattern and identification of two novel mutations in Indian population. (PMID: 19365794) Ahmad F. … Das B.R. (Hematol Oncol 2009) 3 22 46 64

Products for NPM1 Gene

Sources for NPM1 Gene

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