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NPM1 Gene

protein-coding GIFtS: 68

GC05P170746

nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
B23 ^¹, ²
MGC104254 ^²
NPM ^¹, ², ³
Numatrin ^³
numatrin ^²

Descriptions
Nucleolar phosphoprotein B23 ^², ³
Nucleolar protein NO38 ^³
nucleophosmin (nucleolar phosphoprotein B23, numatrin) ^²
nucleophosmin 1 ^²
nucleophosmin/nucleoplasmin family, member 1 ^²

External Ids
HGNC: 7910¹
Entrez Gene: 4869²
UniProtKB: P06748³
Ensembl: ENSG00000181163⁷

Search outside databases for aliases for NPM1 gene

Previous GC identifers: GC05P171050 GC05P171517 GC05P170750 GC05P170795

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NPM1:

NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm.

It is implicated in multiple functions, including ribosomal protein assembly and transport,

control of centrosome duplication, and regulation of the tumor suppressor ARF (MIM 600160). NPM1

mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development

of acute myeloid leukemia (AML; MIM 601626) (Garzon et al., 2008 [PubMed 18308931]).[supplied by

OMIM]

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748

Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome

duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor

suppressors TP53/p53 and ARF. Binds ribosome presumably to drive ribosome nuclear export.

Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids.

Acts as a chaperonin for the core histones H3, H2B and H4

Gene Wiki entry for NPM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NPM1 gene

Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35

NPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P170746: (about GC identifiers)

Start:	170,747,403 bp from pter
End:	170,770,493 bp from pter
Size:	23,091 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748 (See protein sequence)

Recommended Name: Nucleophosmin

Size: 294 amino acids; 32575 Da

Subunit: Decamer formed by two pentameric rings associated in a head-to-head fashion.

Disulfide-linked dimers under certain conditions. The SWAP complex consists of NPM1, NCL, PARP1

and SWAP70 (By similarity). Interacts with NSUN2. Interacts with hepatitis delta virus S-HDAg

Subcellular location: Nucleus, nucleolus. Note=Generally nucleolar, but is translocated to the

nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the

cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML.

Can shuttle between cytoplasm and nucleus

PDB structure from and Proteopedia :

2P1B (3D)

2VXD (3D)

Secondary accessions: P08693 Q12826 Q13440 Q13441 Q14115 Q5EU94 Q5EU95 Q5EU96 Q5EU97 Q5EU98 Q5EU99

Q6V962 Q8WTW5 Q96AT6 Q96DC4 Q96EA5

Alternative splicing: 2 isoforms: P06748-1 P06748-2

Post-translational modifications:

Acetylated at C-terminal lysine residues, thereby increasing affinity to histones¹

ADP-ribosylated¹

Phosphorylated at Ser-4 by PLK1. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at

Thr-199 may trigger initiation of centrosome duplication. Phosphorylated by CDC2 at Thr-199,

Thr-219, Thr-234 and Thr-237 during cell mitosis. When these four sites are phosphorated,

RNA-binding activity seem to be abolished. May be phosphoryled at Ser-70 by NEK2¹

Sumoylated by ARF¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001032827.1 NP_002511.1 NP_954654.1

ENSEMBL proteins:

ENSP00000377408 ENSP00000296930 ENSP00000341168

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Nucleophosmin, Mutant Nucleophosmin (AML marker))
	Human Recombinant Proteins from Abnova (NPM1)

OriGene Purified Recombinant Human Proteins (see all 2): NPM1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12080348
GO:0005654	nucleoplasm	IDA	12058066
GO:0005730	nucleolus	IDA	12080348 16041368 17475909
GO:0005737	cytoplasm	IDA	9121481
GO:0031616	spindle pole centrosome	IDA	16041368

About this table

Antibodies for NPM1:

	Invitrogen Antibodies for NPM1
	Millipore Mono- and Polyclonal Antibodies for the study of NPM1
	Sigma-Aldrich Antibodies for NPM1
	R&D Systems Antibodies for NPM1
	Cell Signaling Technology (CST) Antibodies for NPM1 (NPM)
	Antibodies from Abcam (Nucleophosmin, Mutant Nucleophosmin (AML marker)), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NPM1)
	Novus Biologicals Antibodies for NPM1

Assays for NPM1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06748

ProtoNet protein and cluster: P06748

1 Blocks protein family: IPB004301 Nucleoplasmin

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748

Similarity: Belongs to the nucleoplasmin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NPM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NPM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199185

Applied Biosystems Silencer® siRNAs for NPM1

Sigma-Aldrich siRNA and siRNA Panels for NPM1

Sigma-Aldrich shRNA for NPM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NPM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001037738
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001037738
untagged cDNA clones in CMV expression vector (see all 6): NM_001037738

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002520

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748

Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome

duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor

suppressors TP53/p53 and ARF. Binds ribosome presumably to drive ribosome nuclear export.

Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids.

Acts as a chaperonin for the core histones H3, H2B and H4

Genatlas biochemistry entry for NPM1:

nucleophosmin,interferon 1 (IRF1) binding protein,involved in anaplastic nodal non Hodgkin lymphoma

and B cell lymphoma with translocation t(2;5)(p23;q35),see ALK,and in acute promyelocytic leukemia

with translocation t(5;17) and myelodysplastic syndrome

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Npm1):

cellular	embryogenesis	growth/size	hematopoietic system	lethality-prenatal/perinatal
liver/biliary system	nervous system	skin/coat/nails	tumorigenesis	vision/eye

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IDA	15087454
GO:0003723	RNA binding	IDA	12058066
GO:0030957	Tat protein binding	IDA	9094689
GO:0042393	histone binding	IDA	11602260
GO:0042803	protein homodimerization activity	IDA	9121481

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NPM1

5/349 Interacting proteins for NPM1 (ENSP00000296930³ P06748^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 349 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDM2	Q00987¹	STRING (score=.98) EBI-78579, EBI-389668
SENP3	Q9H4L4²	STRING (score=.972) MINT-6541744 MINT-6541756 MINT-6541718 MINT-6541768 MINT-6541788
EIF2AK2	P19525²	STRING (score=.909) MINT-3089429 MINT-3089371 MINT-3089394
HDAC1	Q13547²	STRING (score=.707) MINT-4544916 MINT-4544899
RPL23	P62829²	STRING (score=.758) MINT-6489539 MINT-6488791

About this table

5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IDA	11602260
GO:0006886	intracellular protein transport	TAS	12080348
GO:0006913	nucleocytoplasmic transport	TAS	12080348
GO:0006916	anti-apoptosis	NAS	16130169
GO:0006950	response to stress	IMP	12080348

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NPM1
10/21 Novoseek chemical compound relationships for NPM1 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
b 231	89.46	7	11481036 (2), 18024892 (2), 12450141 (1), 7527039 (1) (see all 5)
[alcl]	87.90	24	8781434 (3), 9844824 (2), 9250148 (2), 16049513 (1) (see all 14)
cl 100	62.76	7	9013447 (5), 7961985 (1), 9178761 (1)
mnda	60.32	7	9328447 (4), 9712147 (1)
tyrosine	43.49	45	18450602 (2), 8866227 (1), 11110708 (1), 9209644 (1) (see all 32)
adenylosuccinate	39.29	2	9810514 (1), 8575443 (1)
rrna	31.61	12	18259216 (4), 19188445 (2), 16777843 (2), 2071236 (1) (see all 5)
silver	21.52	10	7474921 (3), 7523152 (1), 10588056 (1), 17215513 (1) (see all 7)
polyacrylamide	5.30	3	18345031 (1), 18801061 (1), 7772597 (1)
glyceraldehyde 3-phosphate	3.49	3	18663951 (1), 14678012 (1), 11904414 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NPM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NPM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199185

Sigma-Aldrich siRNA and siRNA Panels for NPM1

Sigma-Aldrich shRNA for NPM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001037738 NM_002520 NM_199185

REFSEQ mRNAs for NPM1 gene (3 alternative transcripts):

NM_001037738.1 NM_002520.5 NM_199185.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001037738 NM_002520 NM_199185

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001037738
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001037738
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001037738

Additional cDNA sequence:

AB042278.1 AB451236.1 AB451361.1 AK000472.1 AK290652.1 AY347529.1 AY740634.1 AY740635.1

AY740636.1 AY740637.1 AY740638.1 AY740639.1 AY740640.1 BC002398.2 BC003670.1 BC008495.1

BC009623.2 BC012566.1 BC014349.1 BC016716.1 BC016768.1 BC016824.1 BC020467.1 BC021668.1

BC021983.1 BC050628.1 BC107754.1 BT007011.1 CR590741.1 CR594093.1 CR595866.1 CR596514.1

CR597478.1 CR601970.1 CR603012.1 CR604830.1 CR605572.1 CR608915.1 CR610343.1 CR612984.1

CR618462.1 CR618961.1 D28343.1 DQ303464.1 EF429251.1 J02590.1 M23613.1 M26697.1

M28699.1 M31004.1 X16934.1

24/113 DOTS entries (see all 113 ):

DT.87018247 DT.100740910 DT.95370767 DT.100809844 DT.95192066 DT.100740963 DT.100045881 DT.91783476

DT.91783568 DT.95370553 DT.91674473 DT.100740960 DT.95370562 DT.100740946 DT.100740934 DT.100045872

DT.100740901 DT.91783601 DT.95370585 DT.121476294 DT.100849758 DT.120890192 DT.100740969 DT.120876428

24/3382 AceView cDNA sequences (see all 3382 ):

BM799688 BI255494 CB133854 BQ644026 BM828863 BM475852 BM915700 BQ772592

BQ049239 BM794091 BQ183627 BQ272367 BE882760 CA448475 BU160205 BU633512

CA419997 BP367796 CA422976 CA420232 BQ222036 BQ048874 CF146565 BP361801

highest scoring ESTs for NPM1:

AA033752 AA035121 AA053108 AA074067 AA113198 AA113248 AA126842 AA129100 AA143310 AA146762

Unigene Cluster for NPM1:

Nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Hs.557550 [show with all ESTs]

Unigene Representative Sequence: BM541948

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPM1 (see all 6 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b
SP1:																			-		-				-
SP2:
SP3:							-		-		-		-		-		-		-		-		-		-		-
SP4:
SP5:																									-

About this scheme

ECgene alternative splicing isoforms for NPM1

3 Ensembl transcripts including schematic representations:

ENST00000393820 ENST00000296930 ENST00000351986

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NPM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NPM1

¹ / ² / ³

9 probe-sets matching NPM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88066_s_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.99	AA857840	0.60	1.00	0.82	1
78344_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.98	AA191576	0.60	1.00	0.82	1
38542_at²^{, 3}	U95-A	27	1.00	0.17	0.68	1.03	U89322	0.20	0.50	0.38	1
221923_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AA191576	0.60	1.00	0.82	1
200063_s_at²^{, 3}	U133-B	18	1.00	0.25	--	--	BC002398	0.80	1.00	0.91	1
221691_x_at²^{, 3}	U133-A	37	1.00	0.20	--	--	AB042278	0.60	1.00	0.82	1
221923_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
200063_s_at²	U133Plus2	18	1.00	0.25	--	--	--	--	--	--	--
221691_x_at²	U133Plus2	37	1.00	0.20	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.557550
Expression variation in blood from EXPOLDB for NPM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NPM1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NPM1¹	--	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	94.48(n) 96.55(a)	606906 XM_843238.1 XP_848331.1
chimpanzee (Pan troglodytes)	NPM1¹	--	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	99.66(n) 100(a)	738662 XM_001151979.1 XP_001151979.1
cow (Bos taurus)	LOC507211¹	--	similar to nucleophosmin 1	92.64(n) 93.79(a)	507211 XM_583781.3 XP_583781.1
rat (Rattus norvegicus)	LOC300303¹	--	similar to Nucleophosmin (NPM) (Nucleolar phosphoprotein more	90.22(n) 92.49(a)	300303 XM_213108.4 XP_213108.3
mouse (Mus musculus)	Npm1⁵ EG434373¹	11⁵	nucleophosmin 1⁵ predicted gene, EG434373¹	90.26(n)¹ 91.9(a)¹	434373¹ XM_486188.4¹ XP_486188.4¹ AI323810⁵ AK005420⁵ (see all 23)

About this table Species with no ortholog for NPM1

ENSEMBL Gene Tree for NPM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NPM1 gene

NPM3² ENSG00000214774² NPM2²

Pseudogenes

34 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in NPM1 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11134695^1,2	A,C,H	170746967(+)	`TAAAAA/TATTCC`	3	--	ng5¹		1		EU	118
--	rs4513711^1,2	A,C	170766689(+)	`atggtA/Gagagt`	3	--	ng3¹ int¹		0	--	--	--	--
	rs10040817^1,2	F,H	170770663(+)	`GCTGTG/TTTCCC`	2	--	ng3¹		4		EU EA WA	418
--	rs7704680^1,2	F,H	170746146(+)	`cagcgG/Tagatc`	3	--	ng5¹		4		EU EA WA	400
--	rs10040865^1,2	A,C	170770889(+)	`aagcaA/Ggtctc`	2	--	ng3¹		0	--	--	--	--
	rs28411384^1,2	F	170746628(+)	`GGCTTC/TTGTAG`	3	--	ng5¹		2		MN EA	1252
--	rs10040851^1,2	A	170770944(+)	`cagccC/Tggcta`	2	--	ng3¹		0	--	--	--	--
--	rs28411383^1,2	F	170746557(+)	`TGCCT-/TCGGAG`	3	--	ng5¹		2		MN EA	1252
--	rs6859650^1,2	H	170770263(+)	`ATGCAG/AAGTGA`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs11134696^1,2	A,C,F,H	170749006(+)	`AGACAT/CATGTA`	3	--	int¹		7		NA EU EA WA	562

About this table

HapMap Linkage Disequilibrium images for NPM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164040

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748

A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma.

Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and

the kinase becomes constitutively activated

A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic

leukemia. Translocation t(5;17)(q32;q11) with RARA

A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS).

Translocation t(3;5)(q25.1;q34) with MLF1

Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12

affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location

10/38 Novoseek disease relationships for NPM1 gene (see all 38 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anaplastic large cell lymphoma	88.67	31	8866227 (2), 17608768 (2), 9665204 (1), 9736036 (1) (see all 21)
aml adult	76.97	16	16455950 (1), 18726096 (1), 17440048 (1), 17597811 (1) (see all 10)
lymphomatoid papulosis	71.77	1	8781434 (1)
lymphoma large cell	71.65	9	17464320 (2), 11110708 (1), 15208656 (1), 16596703 (1) (see all 6)
minimal residual disease	66.15	22	17361227 (2), 19055671 (2), 18830256 (1), 17488663 (1) (see all 13)
lymphoma	65.34	118	8187071 (4), 17488663 (3), 8859196 (2), 15233906 (2) (see all 60)
leukemia promyelocytic acute	63.69	7	15870172 (1), 10393836 (1), 9989813 (1), 8952164 (1) (see all 5)
leukemogenesis	63.12	11	16540653 (2), 17076533 (1), 17475909 (1), 17605889 (1) (see all 8)
aml childhood	60.06	14	19020547 (3), 15870172 (2), 17597811 (2), 17440048 (1) (see all 5)
leukemia	51.02	38	18718053 (3), 17488663 (3), 18450602 (3), 17598835 (2) (see all 18)

About this table

Genatlas disease: NPM1

acute promyelocytic leukemia (APL) gene fused with RARA in t(5;17) translocation (see RARA)

Genetic Association Database: NPM1
Human Genome Epidemiology Navigator: NPM1 (23 documents)
Tumor Gene Database: NPM1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/500 PubMed articles for NPM1 gene (see all 500 ):

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PubMed id 8122112)^{1, 2, 3, 4} Morris S.W....Look A.T. (1994)
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. (PubMed id 15659725)^{1, 3, 4} Falini B.... Martelli M.F. (2005)
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. (PubMed id 15973451)^{1, 3, 6} Noguera N.I....Lo-Coco F. (2005)
Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. (PubMed id 15870172)^{1, 3, 6} Cazzaniga G....Falini B. (2005)
Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region. (PubMed id 9092633)^{1, 3, 4} Chan P.-K.... Xie Z. (1997)
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PubMed id 8570204)^{1, 3, 4} Yoneda-Kato N.... Morris S.W. (1996)
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. (PubMed id 8562957)^{1, 3, 4} Redner R.L.... Corey S.J. (1996)
Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. (PubMed id 16046528)^{1, 3, 6} Boissel N....Preudhomme C. (2005)
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). (PubMed id 8633037)^{1, 3, 4} Fujimoto J....Yamamoto T. (1996)
Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface. (PubMed id 17879352)^{3, 4} Lee H.H....Suh S.W. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4869	HGNC: 7910	AceView: NPM1	Ensembl:ENSG00000181163	euGenes: HUgn4869
ECgene: NPM1	H-InvDB: NPM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NPM1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NPM1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NPM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NPM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NPM1		Antibodies for NPM1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NPM1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NPM1)
	Antibodies (NPM1)
	Chimera RNAi (NPM1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NPM1 (NPM)

	Recombinant Proteins (Nucleophosmin, Mutant Nucleophosmin (AML marker))
	Antibodies (Nucleophosmin, Mutant Nucleophosmin (AML marker))

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NPM1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NPM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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NPM1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for NPM1

Summaries
for NPM1

Genomic Location
for NPM1

Proteins
for NPM1

Protein Domains/
Families
for NPM1

Gene Function
for NPM1

Pathways & Interactions
for NPM1

Drugs & Compounds
for NPM1

Transcripts
for NPM1

Expression
for NPM1

Orthologs
for NPM1

Paralogs
for NPM1

SNPs/Variants
for NPM1

Disorders & Mutations
for NPM1

Medical News
for NPM1

Publications
for NPM1

Search for NPM1

Genome Databases showing NPM1

Other Databases showing NPM1

Specialized Databases showing NPM1

Licensable Technologies
for NPM1

Services
for NPM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NPM1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor NPM1

Summariesfor NPM1

Genomic Locationfor NPM1

Proteinsfor NPM1

Protein Domains/Familiesfor NPM1

Gene Functionfor NPM1

Pathways & Interactionsfor NPM1

Drugs & Compoundsfor NPM1

Transcriptsfor NPM1

Expression for NPM1

Orthologsfor NPM1

Paralogsfor NPM1

SNPs/Variantsfor NPM1

Disorders & Mutationsfor NPM1

Medical Newsfor NPM1

Publicationsfor NPM1

Search for NPM1

Genome Databases showing NPM1

Other Databases showing NPM1

Specialized Databases showing NPM1

Licensable Technologiesfor NPM1

Servicesfor NPM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NPM1

Summaries
for NPM1

Genomic Location
for NPM1

Proteins
for NPM1

Protein Domains/
Families
for NPM1

Gene Function
for NPM1

Pathways & Interactions
for NPM1

Drugs & Compounds
for NPM1

Transcripts
for NPM1

Expression
for NPM1

Orthologs
for NPM1

Paralogs
for NPM1

SNPs/Variants
for NPM1

Disorders & Mutations
for NPM1

Medical News
for NPM1

Publications
for NPM1

Licensable Technologies
for NPM1

Services
for NPM1