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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPM1 Gene

protein-coding   GIFtS: 64
GCID: GC05P170814

nucleophosmin (nucleolar phosphoprotein B23, numatrin)
 Explore 60 diseases affiliated with
NPM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPM1    

Aliases
for NPM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin)1 2     Nucleophosmin1
NPM1 2 3     Nucleophosmin/Nucleoplasmin Family, Member 12
B231 2     Numatrin3
Nucleolar Protein NO382 3     Nucleolar Phosphoprotein B233

External Ids:    HGNC: 79101   Entrez Gene: 48692   Ensembl: ENSG000001811637   OMIM: 1640405   UniProtKB: P067483   

Export aliases for NPM1 gene to outside databases

Previous GC identifers: GC05P171050 GC05P171517 GC05P170750 GC05P170795 GC05P170746 GC05P170747 GC05P165912


Summaries
for NPM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NPM1:
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be
involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have
been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are
associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative
splicing results in multiple transcript variants.(provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: NPM_HUMAN, P06748
Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein
chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds
ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind
single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1
endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP
single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA
and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates
centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication

Gene Wiki entry for NPM1


Genomic Views
for NPM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPM1 gene promoter:
         AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NPM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

NPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPM1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170814:  view genomic region     (about GC identifiers)

Start:
 170,814,120 bp from pter      End:
 170,838,141 bp from pter
Size:
 24,022 bases      Orientation:
 plus strand

Proteins
for NPM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPM_HUMAN, P06748 (See protein sequence)
Recommended Name: Nucleophosmin  
Size: 294 amino acids; 32575 Da
Subunit: Decamer formed by two pentameric rings associated in a head-to-head fashion. Disulfide-linked dimers under
certain conditions. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2 and
SENP3. Interacts with hepatitis delta virus S-HDAg. Interacts with HTLV1 Rex protein (via N-terminal nuclear
localization signal). Interacts with the methylated form of RPS10. Interacts (via N-terminal domain) with APEX1; the
interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts with isoform 1 of NEK2.
Interacts with ROCK2 and BRCA2. Interacts with RPGR. Interacts with CENPW
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Generally
nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has
been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can
shuttle between cytoplasm and nucleus. Co-localizes with the methylated form of RPS10 in the granular component (GC)
region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its
localization to the centrosome during mitosis
3 PDB 3D structures from and Proteopedia for NPM1:
2LLH (3D)        2P1B (3D)        2VXD (3D)    
Secondary accessions: A8K3N7 B5BU00 D3DQL6 P08693 Q12826 Q13440 Q13441 Q14115 Q5EU94 Q5EU95 Q5EU96
Q5EU97 Q5EU98 Q5EU99 Q6V962 Q8WTW5 Q96AT6 Q96DC4 Q96EA5 Q9BYG9 Q9UDJ7
Alternative splicing: 3 isoforms:  P06748-1   P06748-2   P06748-3   (Contains a N6-acetyllysine at position 257. Contains a phosphoserine at position 254)

Explore the universe of human proteins at neXtProt for NPM1: NX_P06748

Post-translational modifications:

  • Acetylated at C-terminal lysine residues, thereby increasing affinity to histones1
  • ADP-ribosylated1
  • Phosphorylated at Ser-4 by PLK1 and PLK2. Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole
    • duplication and is sufficient to trigger centriole replication. Phosphorylation at Ser-4 by PLK1 takes place during
    mitosis. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at Thr-199 may trigger initiation of
    centrosome duplication. Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis. When
    these four sites are phosphorated, RNA-binding activity seem to be abolished. May be phosphorylated at Ser-70 by NEK2.
    The Thr-199 phosphorylated form has higher affinity for ROCK2. CDK6 triggers Thr-199 phosphorylation when complexed to
    Kaposi's sarcoma herpesvirus (KSHV) V-cyclin, leading to viral reactivation by reducing viral LANA levels1
  • Sumoylated by ARF1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P06748

    • NPM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001032827.1  NP_002511.1  NP_954654.1  

    ENSEMBL proteins: 
     ENSP00000428755   ENSP00000296930   ENSP00000429485   ENSP00000341168   ENSP00000377408  
     ENSP00000428647  
    Reactome Protein details: P06748
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 3): NPM1
    OriGene Protein Over-expression Lysate (see all 3): NPM1
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    Novus Biologicals NPM1 Protein
    Novus Biologicals NPM1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NPM1
    Uscn Proteins for NPM1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome ISS--


    NPM1 for ontologies           About GeneDecksing



    NPM1 Antibody Products: 
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    Cell Signaling Technology (CST) Antibodies for NPM1 
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    ThermoFisher Antibody for NPM1

    Assay Products for NPM1: 
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    Uscn ELISAs and CLIAs for NPM1

    Protein Domains /
    Families
    for NPM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPM1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024057 Nucleoplasmin_core
     IPR004301 Nucleoplasmin

    Graphical View of Domain Structure for InterPro Entry P06748

    ProtoNet protein and cluster: P06748

    1 Blocks protein family: IPB004301 Nucleoplasmin

    UniProtKB/Swiss-Prot: NPM_HUMAN, P06748
    Similarity: Belongs to the nucleoplasmin family


    Function
    for NPM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPM_HUMAN, P06748
    Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein
    chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds
    ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind
    single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1
    endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP
    single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA
    and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates
    centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication

         Genatlas biochemistry entry for NPM1:
    nucleophosmin,interferon 1 (IRF1) binding protein,involved in anaplastic nodal non Hodgkin lymphoma and B cell lymphoma
    with translocation t(2;5)(p23;q35),see ALK,and in acute promyelocytic leukemia with translocation t(5;17) and
    myelodysplastic syndrome

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPM1
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NPM1:
    hsa-miR-587 hsa-miR-548am hsa-miR-182 hsa-miR-548x hsa-miR-543 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmid: NPM1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPM1 (see all 7)
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    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPM1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPM1 (see all 6)
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    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IDA15087454
    GO:0003723RNA binding IDA12058066
    GO:0005515protein binding IPI15144954
    GO:0019901protein kinase binding IPI--


    NPM1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Npm1tm2Ppp for NPM1
         12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Npm1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 
     tumorigenesis  vision/eye 

    NPM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    2HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64
    3Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Nuclear import of Rev protein0.76
    		Interactions of Rev with host cellular proteins0.72
    4Development HGF signaling pathway
    		Apoptosis and survival_NGF signaling pathway0.25
    		Apoptosis and survival NGF signaling pathway0.25
    5Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NPM1
        Apoptosis and survival NGF signaling pathway


    2 Cell Signaling Technology (CST) Pathways for NPM1
        Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for NPM1
        Apoptosis and survival NGF signaling pathway

    4 BioSystems Pathways for NPM1 
        HIF-1-alpha transcription factor network
    Aurora B signaling
    BARD1 signaling events
    Validated targets of C-MYC transcriptional activation

    5/11        Reactome Pathways for NPM1 (see all 11)
        Nuclear import of Rev protein
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere



    NPM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/931 Interacting proteins for NPM1 (P067481, 2, 3 ENSP000002969304) via UniProtKB, MINT, STRING, and/or I2D (see all 931)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-7899812 I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IDA19188445
    GO:0006334nucleosome assembly TAS--
    GO:0006886intracellular protein transport TAS12080348
    GO:0006913nucleocytoplasmic transport TAS12080348
    GO:0006950response to stress IMP12080348


    NPM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPM1
    10/44 Novoseek chemical compound relationships for NPM1 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 231 88.6 7 11481036 (2), 18024892 (2), 12450141 (1), 7527039 (1) (see all 5)
    [alcl] 87.6 32 8781434 (3), 9844824 (2), 9250148 (2), 16049513 (1) (see all 16)
    cl 100 61.4 7 9013447 (5), 7961985 (1), 9178761 (1)
    actinomycin d 59.3 28 1381705 (5), 1697505 (3), 1756512 (3), 1399149 (2) (see all 15)
    mnda 58.1 7 9328447 (4), 9712147 (1)
    tyrosine 45.5 51 18450602 (2), 8866227 (1), 11110708 (1), 9209644 (1) (see all 34)
    retinoic acid 40.7 14 1568462 (6), 17318229 (3), 8562957 (1), 10360373 (1) (see all 5)
    5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole 37.1 3 16342411 (1), 8799815 (1)
    adenylosuccinate 37 2 9810514 (1), 8575443 (1)
    leptomycin b 35.1 6 16041368 (2), 16455950 (1), 16720834 (1)

    Search CenterWatch for drugs/clinical trials and news about NPM1 / NPM 

    Transcripts
    for NPM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPM1 gene (3 alternative transcripts): 
    NM_001037738.2  NM_002520.6  NM_199185.3  

    Unigene Cluster for NPM1:

    Nucleophosmin (nucleolar phosphoprotein B23, numatrin)
    Hs.557550  [show with all ESTs]
    Unigene Representative Sequence: BM541948
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517671 ENST00000296930(uc003mbi.3 uc003mbj.3) ENST00000521672
    ENST00000351986 ENST00000393820(uc003mbh.3) ENST00000523339 ENST00000523622
    ENST00000518587 ENST00000521260 ENST00000521710 ENST00000519955 ENST00000524204


    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: NPM1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPM1 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB042278.1 AB451236.1 AB451361.1 AK000472.1 AK290652.1 AY347529.1 AY740634.1 AY740635.1 
    AY740636.1 AY740637.1 AY740638.1 AY740639.1 AY740640.1 BC002398.2 BC003670.1 BC008495.1 
    BC009623.2 BC012566.1 BC014349.1 BC016716.1 BC016768.1 BC016824.1 BC020467.1 BC021668.1 
    BC021983.1 BC050628.1 BC107754.1 BT007011.1 D28343.1 DQ303464.1 EF429251.1 J02590.1 
    M23613.1 M26697.1 M28699.1 M31004.1 X16934.1 

    24/108 DOTS entries (see all 108):

    DT.87018247  DT.95370767  DT.100740910  DT.95192066  DT.100809844  DT.100045881  DT.100740963  DT.91783568 
    DT.95370553  DT.91783476  DT.100740960  DT.91674473  DT.95370562  DT.100740946  DT.100740934  DT.91783601 
    DT.100045872  DT.100740901  DT.95370585  DT.121476294  DT.100849758  DT.100740969  DT.120890192  DT.100740877 

    24/3382 AceView cDNA sequences (see all 3382):

    BU071580 CA422986 BQ929615 BQ951375 BP338869 BQ272367 BX457428 BU627133 
    AA315691 BG681878 CR605572 CA418015 CB139862 CB127440 BG746981 BX450126 
    BM762526 BU616579 BQ630970 BM451941 CA393364 BU183708 BU165417 BE379937 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPM1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                                        -     -           -                           
    SP2:                                                                                                      
    SP3:                    -     -     -     -     -     -     -     -     -     -     -                     
    SP4:                                                                                                      
    SP5:                                                                          -                           


    ECgene alternative splicing isoforms for NPM1

    Expression
    for NPM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NPM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    VUB02 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB03_DM1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB04_CF (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB07 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB09_FSHD (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NPM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPM1

    SOURCE GeneReport for Unigene cluster: Hs.557550
        SABiosciences Expression via Pathway-Focused PCR Arrays including NPM1: 
              Leukemia in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPM1
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPM1
    In Situ
    Assay Products:     
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    Orthologs
    for NPM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPM1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Npm11 , 5 nucleophosmin 11, 5 91.52(n)1
    96.22(a)1    		   11 (19.21 cM)5
    181481  NM_008722.31  NP_032748.11 
     331522875 
    chicken
    (Gallus gallus)    		 Aves NPM11 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 72.99(n)
    71.72(a)    		   396203  NM_205267.1  NP_990598.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NPM16
    		 --
    		 60(a)
    		 1 ↔ 1
    		 1(130273655-130288409)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia MGC756882 hypothetical protein MGC75688 75.64(n)    BC059736.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii npm1a1 nucleophosmin 1a 59.55(n)
    51.25(a)    		   266985  NM_199428.1  NP_955460.1 


    ENSEMBL Gene Tree for NPM1 (if available)
    TreeFam Gene Tree for NPM1 (if available) 

    Paralogs
    for NPM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPM1 gene
    NPM32  NPM22  
    3 SIMAP similar genes for NPM1 using alignment to 6 protein entries:     NPM_HUMAN (see all proteins):
    CLEC2D    NPM3    NPM2

    NPM1 for paralogs           About GeneDecksing


    5/51 Pseudogenes.org Pseudogenes for NPM1 (see all 51)
    PGOHUM00000238528 PGOHUM00000238599 PGOHUM00000238690 PGOHUM00000238901 PGOHUM00000238963


    Genomic Variants
    for NPM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 NCBI SNPs in NPM1 are shown (see all 525)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs724945221,2
    		C,F,--170812774(+) CGGGCG/ACCATG 3 -- us2k12Minor allele frequency- A:0.06NA EA 240
    rs1930322231,2
    		--170812778(+) CGCCAG/TGGCTC 3 -- us2k10--------
    rs1411267831,2
    		--170812846(+) AGTTCA/GAGTCC 3 -- us2k10--------
    rs1502772091,2
    		--170812941(+) TACTTA/GGGAGG 3 -- us2k10--------
    rs1851879491,2
    		--170813034(+) CAGAGC/TGGGAC 3 -- us2k10--------
    rs592617901,2
    		C--170813049(+) AAAAA-/ATTAAA 3 -- us2k10--------
    rs1389275551,2
    		--170813169(+) ACAACA/GATTAG 4 -- us2k1 ds50010--------
    rs1421833321,2
    		--170813225(+) TGAGGC/TACGAG 4 -- ds5001 us2k10--------
    rs1903975541,2
    		--170813483(+) TGGTGA/GCATGC 4 -- us2k1 ds50010--------
    rs1930686521,2
    		--170813540(+) CCAGCA/GGAGAT 4 -- ds5001 us2k10--------

    HapMap Linkage Disequilibrium report for NPM1 (170814120 - 170838141 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPM1: --

    5/7 SABiosciences Cancer Mutation PCR Assays for NPM1 (see all 7):
    Cosmic IdAA Change
    20814p.W288fs*12
    17573p.W288fs*12
    17559p.W288fs*12
    17571p.W288fs*12
    20815p.W288fs*12
    5/6 SABiosciences Cancer Mutation PCR Arrays containing NPM1 (see all 6):
    Oncogene and Tumor Suppressor Panel 384HT
    Hematopoietic Neoplasms
    Acute Myeloid Leukemia
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPM1
    DNA2.0 Custom Variant and Variant Library Synthesis for NPM1

    Disorders / Diseases
    for NPM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPM1 for disorders           About GeneDecksing

    OMIM gene information: 164040   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: NPM_HUMAN, P06748
  • Note=A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation
    • t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively
    activated
  • Note=A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation
    • t(5;17)(q32;q11) with RARA
  • Note=A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation
    • t(3;5)(q25.1;q34) with MLF1
  • Note=Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the
    • C-terminus of the protein are associated with an aberrant cytoplasmic location

    20/60 diseases for NPM1 (see all 60):    About MalaCards
    leukemia, acute promyelocytic, npm/rara type    acute myeloid leukemia    myeloid leukemia    blastic plasmacytoid dendritic cell
    lymphomatoid papulosis    shwachman-diamond syndrome    leukemia    anaplastic large cell lymphoma
    non-small cell lung carcinoma    treacher collins syndrome    non-hodgkin lymphoma    japanese encephalitis
    myelomonocytic leukemia    fanconi's anemia    b-cell lymphomas    chronic myelomonocytic leukemia
    metastasis efficiency    liver cirrhosis    oral squamous cell carcinoma    mantle cell lymphoma

    3 diseases from the University of Copenhagen DISEASES database for NPM1:
    Acute myeloid leukemia     Reticulosarcoma     Lymphoma

    10/39 Novoseek disease relationships for NPM1 gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaplastic large cell lymphoma 88.6 35 8866227 (2), 17608768 (2), 9665204 (1), 9736036 (1) (see all 23)
    aml adult 78.4 20 16455950 (1), 18726096 (1), 17440048 (1), 17597811 (1) (see all 13)
    lymphoma large cell 70.2 9 17464320 (2), 11110708 (1), 15208656 (1), 16596703 (1) (see all 6)
    lymphomatoid papulosis 69.9 1 8781434 (1)
    minimal residual disease 66.9 24 17361227 (2), 19055671 (2), 18830256 (1), 17488663 (1) (see all 14)
    lymphoma 64.9 126 8187071 (4), 17488663 (3), 8859196 (2), 15233906 (2) (see all 64)
    leukemogenesis 64.9 13 16540653 (2), 17076533 (1), 17475909 (1), 19817644 (1) (see all 9)
    leukemia promyelocytic acute 61.7 7 15870172 (1), 10393836 (1), 9989813 (1), 8952164 (1) (see all 5)
    aml childhood 57.4 14 19020547 (3), 15870172 (2), 17597811 (2), 17440048 (1) (see all 5)
    leukemia 52.8 43 18718053 (3), 17488663 (3), 18450602 (3), 17598835 (2) (see all 21)

    Genatlas disease: NPM1
    acute promyelocytic leukemia (APL) gene fused with RARA in t(5;17) translocation (see RARA)

    Genetic Association Database (GAD): NPM1
    Human Genome Epidemiology (HuGE) Navigator: NPM1 (75 documents)
    Tumor Gene Database (TGDB): NPM1

    Export disorders for NPM1 gene to outside databases

    Publications
    for NPM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPM1 gene, integrated from 9 sources (see all 788):
    (articles sorted by number of sources associating them with NPM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PubMed id 8122112)1, 2, 3, 9 Morris S.W.... Look A.T. (1994)
    2. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. (PubMed id 15659725)1, 2, 9 Falini B.... Martelli M.F. (2005)
    3. Structural consequences of nucleophosmin mutations in acute myeloid leukemia. (PubMed id 18511415)1, 2, 9 Grummitt C.G.... Bycroft M. (2008)
    4. Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. (PubMed id 15870172)1, 4, 9 Cazzaniga G....Falini B. (2005)
    5. Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. (PubMed id 15973451)1, 4, 9 Noguera N.I....Lo-Coco F. (2005)
    6. The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. (PubMed id 18259216)1, 2, 9 Haindl M.... Muller S. (2008)
    7. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2, 9 Vascotto C....Tell G. (2009)
    8. Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region. (PubMed id 9092633)1, 2, 9 Chan P.-K.... Xie Z. (1997)
    9. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. (PubMed id 8570204)1, 2, 9 Yoneda-Kato N.... Morris S.W. (1996)
    10. Aurora-B regulates RNA methyltransferase NSUN2. (PubMed id 17215513)1, 2, 9 Sakita-Suto S.... Tatsuka M. (2007)

    External Searches for NPM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4869 HGNC: 7910 AceView: NPM1 Ensembl:ENSG00000181163 euGenes: HUgn4869
    ECgene: NPM1 H-InvDB: NPM1

    Other Databases showing NPM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NPM1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NPM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPM1 gene:
    Search GeneIP for patents involving NPM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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