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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPLOC4 Gene

protein-coding   GIFtS: 55
GCID: GC17M079523

Nuclear Protein Localization 4 Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Protein Localization 4 Homolog (S. Cerevisiae)1 2
NPL42 3 5
KIAA14993 5
Nuclear Protein Localization Protein 4 Homolog2
Protein NPL43

External Ids:    HGNC: 182611   Entrez Gene: 556662   Ensembl: ENSG000001824467   OMIM: 6065905   UniProtKB: Q8TAT63   

Export aliases for NPLOC4 gene to outside databases

Previous GC identifers: GC17M077135 GC17M074971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPLOC4 Gene: 
NPLOC4 (nuclear protein localization 4 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NPLOC4 include nevoid basal cell carcinoma syndrome, and basal cell carcinoma, and among its related super-pathways are Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include protein binding and zinc ion binding.

UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for
the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation
of a closed nuclear envelope (By similarity)

Gene Wiki entry for NPLOC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPLOC4 gene promoter:
         GCNF-1   GCNF   STAT5A   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPLOC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPLOC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPLOC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17qter   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NPLOC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPLOC4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079523:  view genomic region     (about GC identifiers)

Start:
79,523,913 bp from pter      End:
79,615,495 bp from pter
Size:
91,583 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6 (See protein sequence)
Recommended Name: Nuclear protein localization protein 4 homolog  
Size: 608 amino acids; 68120 Da
Subunit: Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and
inhibits Golgi membrane fusion
Subcellular location: Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By
similarity). Note=Associated with the endoplasmic reticulum and nuclear (By similarity)
Sequence caution: Sequence=BAA91314.1; Type=Erroneous initiation; Sequence=BAA96023.1; Type=Erroneous initiation;
Sequence=BAB14372.1; Type=Erroneous initiation; Sequence=BAB14499.1; Type=Erroneous initiation;
Secondary accessions: Q8N3J1 Q9H8V2 Q9H964 Q9NWR5 Q9P229
Alternative splicing: 2 isoforms:  Q8TAT6-1   Q8TAT6-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPLOC4: NX_Q8TAT6

Explore proteomics data for NPLOC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAT6

  • NPLOC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPLOC4 Protein Expression
    REFSEQ proteins: NP_060391.2  
    ENSEMBL proteins: 
     ENSP00000331487   ENSP00000467400   ENSP00000459457   ENSP00000465247   ENSP00000460465  
     ENSP00000458384   ENSP00000459462   ENSP00000363879   ENSP00000461543   ENSP00000461478  
     ENSP00000446199  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPLOC4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ISS11574150
    GO:0005829cytosol IEA--
    GO:0042175nuclear outer membrane-endoplasmic reticulum membrane network ISS11574150

    NPLOC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR007717 NPL4
     IPR016563 PolyUb_recognition_cplx_Npl4
     IPR007716 NPL4_Zn-bd_put
     IPR024682 Npl4_Ub-like_dom
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8TAT6

    ProtoNet protein and cluster: Q8TAT6

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Domain: Binds ubiquitinated proteins via its RanBP2-type zinc finger
    Similarity: Belongs to the NPL4 family
    Similarity: Contains 1 RanBP2-type zinc finger


    NPLOC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPL4_HUMAN, Q8TAT6
    Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for
    the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
    NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation
    of a closed nuclear envelope (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11574150
    GO:0008270zinc ion binding IEA--
         
    NPLOC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nploc4):
     mortality/aging 

    NPLOC4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPLOC4 
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    SwitchGear 3'UTR luciferase reporter plasmidNPLOC4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPLOC4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of wt-CFTR
    Regulation of degradation of wt-CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for NPLOC4
        Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR


    1         Kegg Pathway  (Kegg details for NPLOC4):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway


    NPLOC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPLOC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for NPLOC4 (Q8TAT62, 3 ENSP000003314874) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550722, 3, ENSP000003517774MINT-7903922 MINT-7903948 MINT-7903973 I2D: score=9 STRING: ENSP00000351777
    NSFL1CQ9UNZ22, 3, ENSP000002168794MINT-7903948 MINT-7903973 I2D: score=2 STRING: ENSP00000216879
    UFD1LQ928902, 3, ENSP000002632024MINT-7903922 MINT-7903948 I2D: score=19 STRING: ENSP00000263202
    UBCP0CG482, 3, ENSP000003448184MINT-3973725 I2D: score=4 STRING: ENSP00000344818
    UBE4BO951553, ENSP000003430014I2D: score=4 STRING: ENSP00000343001
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007030Golgi organization ISS11574150
    GO:0030433ER-associated protein catabolic process ISS11574150
    GO:0061025membrane fusion ISS11574150

    NPLOC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPLOC4 (NPL4)

    Search CenterWatch for drugs/clinical trials and news about NPLOC4 / NPL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPLOC4 gene: 
    NM_017921.2  

    Unigene Cluster for NPLOC4:

    Nuclear protein localization 4 homolog (S. cerevisiae)
    Hs.464333  [show with all ESTs]
    Unigene Representative Sequence: AK024398
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000331134(uc002kar.3 uc010dic.3 uc002kas.3 uc002kat.4)
    ENST00000572760 ENST00000574964 ENST00000572346 ENST00000573519 ENST00000573876
    ENST00000571714 ENST00000572824 ENST00000573212 ENST00000576713 ENST00000374747(uc002kau.3 uc010wur.1)
    ENST00000576940 ENST00000574897 ENST00000572351 ENST00000570324 ENST00000573328
    ENST00000574344 ENST00000570300
    miRNA
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    Additional mRNA sequence: 

    AB040932.1 AF086475.1 AK000664.1 AK023046.1 AK023272.1 AK024398.1 AK074322.1 AK294473.1 
    AK311741.1 AL133629.1 AL834300.1 BC013406.2 BC025930.1 

    19 DOTS entries:

    DT.455631  DT.100655372  DT.100655369  DT.92450457  DT.92450459  DT.100044800  DT.120958182  DT.95265878 
    DT.40122399  DT.120958195  DT.40189079  DT.120958162  DT.75116078  DT.120958196  DT.120958206  DT.75151602 
    DT.40260067  DT.97774580  DT.99962343 

    24/448 AceView cDNA sequences (see all 448):

    BM705108 CA413928 BQ013702 BE464901 AW007107 BU538380 BQ226757 CB130175 
    AW193587 AI498719 BG678002 BU542911 BE646377 BE328173 F36694 AI160325 
    AI373440 BQ675518 AK023272 BM670514 BU542187 AW167244 BU542703 AI955240 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NPLOC4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^
    SP1:                                                                    -     -                                   -     -     -                 -     -     -   
    SP2:                                                                                                              -     -     -                 -     -     -   
    SP3:                                                                                                              -     -     -                 -     -     -   
    SP4:                                                                          -                                   -     -     -                                 
    SP5:                                                                                                              -     -     -                 -           -   

    ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e · 23f · 23g · 23h · 23i
    SP1:  -                                                         
    SP2:  -                                                         
    SP3:                                                            
    SP4:                                                            
    SP5:  -                                                         


    ECgene alternative splicing isoforms for NPLOC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPLOC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACCAGCAC
    NPLOC4 Expression
    About this image


    See NPLOC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPLOC4

    SOURCE GeneReport for Unigene cluster: Hs.464333

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including NPLOC4: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPLOC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NPLOC4 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nploc41 , 5 nuclear protein localization 4 homolog (S. cerevisiae)1, 5 89.04(n)1
    97.37(a)1
      11 (84.09 cM)5
    2173651  NM_001195023.11  NP_001181952.11 
     1203803705 
    chicken
    (Gallus gallus)
    Aves NPLOC41 nuclear protein localization 4 homolog (S. cerevisiae) 82.13(n)
    92.43(a)
      417456  XM_415704.3  XP_415704.3 
    lizard
    (Anolis carolinensis)
    Reptilia NPLOC46
    nuclear protein localization 4 homolog (S. cerevis...
    90(a)
    1 ↔ 1
    2(98520722-98581837)
    African clawed frog
    (Xenopus laevis)
    Amphibia npl4-prov2 homolog of yeast nuclear protein localization 4 76.76(n)    BC056013.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi11f092 wufi11f09 78.56(n)   327447  BC045845.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46731 CG4673 55.35(n)
    50.67(a)
      43091  NM_001170260.1  NP_001163731.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npl-4.21 Protein NPL-4.2 51.08(n)
    45.77(a)
      3565577  NM_062692.2  NP_495093.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPL4(YBR170C)4
    NPL41
    Ubiquitin-binding protein involved in protein degradation; more4
    Npl4p1
    45.36(n)1
    36.61(a)1
      2(578086-576344)4
    8524681, 4  NP_009729.11, 4 


    ENSEMBL Gene Tree for NPLOC4 (if available)
    TreeFam Gene Tree for NPLOC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPLOC4 gene
    18/54 SIMAP similar genes for NPLOC4 using alignment to 9 protein entries:     NPL4_HUMAN (see all proteins) (see all similar genes):
    ZNF546    NRAMP1    AEBP2    FOPNL    FAM3A    ZNF738
    PLEKHH2    DCTN5    NEK4    ZNF410    TMEM14B    WARS
    ZNF74    ZNF611    APOPT1    HECW1    QRICH2    CHID1

    NPLOC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1889 SNPs in NPLOC4 are shown (see all 1889)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410560401,2
    C--74971025(+) GGCTC-/CTAT  
            
    CTGAG
    1 -- int10--------
    rs1394024921,2
    --74971105(+) AGGCAA/GTGTGT 1 -- int10--------
    rs1142408001,2
    C,F--74971119(+) CCCCAG/AGCCTC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1178750901,2
    C,F--74971140(+) GCACCT/GGTGCA 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1165673571,2
    C,F--74971197(+) GTACCT/CGTCCA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1144276271,2
    C,F--74971198(+) TACCTG/ATCCAC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1441745091,2
    --74971337(+) ACTTAA/TCGAGG 1 -- int10--------
    rs124538871,2
    C,F,H--74971342(+) TCGAGG/AAGCCA 1 -- int122Minor allele frequency- A:0.22NS EA NA WA 2706
    rs1862244461,2
    --74971362(+) GGGATC/TGGCTG 1 -- int10--------
    rs759837061,2
    C,F--74971422(+) CAGTGA/TTATCT 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for NPLOC4 (79523913 - 79615495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for NPLOC4 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666942CNV Deletion23128226
    esv1319911CNV Deletion17803354
    esv2716454CNV Deletion23290073
    esv2667665CNV Deletion23128226
    nsv2164CNV Insertion18451855
    esv1009816CNV Insertion20482838
    nsv833568CNV Loss17160897
    nsv909110CNV Loss21882294
    dgv3333n71CNV Loss21882294
    dgv3332n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606590    OMIM disorders: --

    3 diseases for NPLOC4:    About MalaCards
    nevoid basal cell carcinoma syndrome    basal cell carcinoma    cholera


    NPLOC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NPLOC4

    Export disorders for NPLOC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPLOC4 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with NPLOC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PubMed id 11574150)1, 2, 3, 9 Botta A....Novelli G. (2001)
    2. Digital quantification of human eye color highlights genetic association of three new loci. (PubMed id 20463881)1, 4 Liu F....Kayser M. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. A complex of mammalian ufd1 and npl4 links the AAA-AT Pase, p97, to ubiquitin and nuclear transport pathways. (PubMed id 10811609)1, 3 Meyer H.H....Warren G. (2000)
    7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    8. Complex of Fas-associated factor 1 (FAF1) with valosin -containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endo plasmic reticulum-associated degradation (ERAD). (PubMed id 23293021)1 Lee J.J....Lee K.J. (2013)
    9. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55666 HGNC: 18261 AceView: NPL4 Ensembl:ENSG00000182446 euGenes: HUgn55666
    ECgene: NPLOC4 Kegg: 55666 H-InvDB: NPLOC4

    (According to HUGE)
    About This Section
    HUGE: KIAA1499

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPLOC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPLOC4 gene:
    Search GeneIP for patents involving NPLOC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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