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Aliases for NPLOC4 Gene

Aliases for NPLOC4 Gene

  • NPL4 Homolog, Ubiquitin Recognition Factor 2 3 5
  • NPLOC4 Ubiquitin Recognition Factor 2 3
  • NPL4 3 4
  • Nuclear Protein Localization 4 Homolog (S. Cerevisiae) 2
  • Nuclear Protein Localization 4 Homolog 3
  • Protein NPL4 4
  • KIAA1499 4

External Ids for NPLOC4 Gene

Previous GeneCards Identifiers for NPLOC4 Gene

  • GC17M077135
  • GC17M079523
  • GC17M074971

Summaries for NPLOC4 Gene

GeneCards Summary for NPLOC4 Gene

NPLOC4 (NPL4 Homolog, Ubiquitin Recognition Factor) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include ubiquitin protein ligase binding and ubiquitin binding.

UniProtKB/Swiss-Prot for NPLOC4 Gene

  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Wiki entry for NPLOC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPLOC4 Gene

Genomics for NPLOC4 Gene

Regulatory Elements for NPLOC4 Gene

Genomic Location for NPLOC4 Gene

Chromosome:
17
Start:
81,556,885 bp from pter
End:
81,648,465 bp from pter
Size:
91,581 bases
Orientation:
Minus strand

Genomic View for NPLOC4 Gene

Genes around NPLOC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPLOC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPLOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPLOC4 Gene

Proteins for NPLOC4 Gene

  • Protein details for NPLOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT6-NPL4_HUMAN
    Recommended name:
    Nuclear protein localization protein 4 homolog
    Protein Accession:
    Q8TAT6
    Secondary Accessions:
    • Q8N3J1
    • Q9H8V2
    • Q9H964
    • Q9NWR5
    • Q9P229

    Protein attributes for NPLOC4 Gene

    Size:
    608 amino acids
    Molecular mass:
    68120 Da
    Quaternary structure:
    • Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.
    SequenceCaution:
    • Sequence=BAA91314.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96023.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14499.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NPLOC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPLOC4 Gene

Proteomics data for NPLOC4 Gene at MOPED

Post-translational modifications for NPLOC4 Gene

  • Ubiquitination at Lys 62, Lys 68, Lys 116, Lys 189, Lys 207, Lys 243, Lys 260, Lys 302, Lys 307, Lys 404, Lys 431, and Lys 544
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NPLOC4 Gene

Domains & Families for NPLOC4 Gene

Gene Families for NPLOC4 Gene

Protein Domains for NPLOC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAT6

UniProtKB/Swiss-Prot:

NPL4_HUMAN :
  • Binds ubiquitinated proteins via its RanBP2-type zinc finger.
  • Belongs to the NPL4 family.
  • Contains 1 RanBP2-type zinc finger.
Domain:
  • Binds ubiquitinated proteins via its RanBP2-type zinc finger.
Family:
  • Belongs to the NPL4 family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with NPLOC4: view

Function for NPLOC4 Gene

Molecular function for NPLOC4 Gene

UniProtKB/Swiss-Prot Function:
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Ontology (GO) - Molecular Function for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574150
genes like me logo Genes that share ontologies with NPLOC4: view
genes like me logo Genes that share phenotypes with NPLOC4: view

Animal Models for NPLOC4 Gene

MGI Knock Outs for NPLOC4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPLOC4 Gene

Localization for NPLOC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPLOC4 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPLOC4 Gene COMPARTMENTS Subcellular localization image for NPLOC4 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036501 UFD1-NPL4 complex IPI 11574150
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network ISS 11574150
genes like me logo Genes that share ontologies with NPLOC4: view

Pathways & Interactions for NPLOC4 Gene

genes like me logo Genes that share pathways with NPLOC4: view

UniProtKB/Swiss-Prot Q8TAT6-NPL4_HUMAN

  • Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway.

Gene Ontology (GO) - Biological Process for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019985 translesion synthesis TAS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process ISS 11574150
GO:0030970 retrograde protein transport, ER to cytosol IMP 25660456
genes like me logo Genes that share ontologies with NPLOC4: view

No data available for SIGNOR curated interactions for NPLOC4 Gene

Drugs & Compounds for NPLOC4 Gene

No Compound Related Data Available

Transcripts for NPLOC4 Gene

Unigene Clusters for NPLOC4 Gene

Nuclear protein localization 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPLOC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e · 23f · 23g · 23h · 23i
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -

Relevant External Links for NPLOC4 Gene

GeneLoc Exon Structure for
NPLOC4
ECgene alternative splicing isoforms for
NPLOC4

Expression for NPLOC4 Gene

mRNA expression in normal human tissues for NPLOC4 Gene

mRNA differential expression in normal tissues according to GTEx for NPLOC4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for NPLOC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9) and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPLOC4 Gene



SOURCE GeneReport for Unigene cluster for NPLOC4 Gene Hs.464333

mRNA Expression by UniProt/SwissProt for NPLOC4 Gene

Q8TAT6-NPL4_HUMAN
Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.
genes like me logo Genes that share expression patterns with NPLOC4: view

Protein tissue co-expression partners for NPLOC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NPLOC4 Gene

Orthologs for NPLOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NPLOC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPLOC4 36
  • 91 (a)
OneToOne
NPLOC4 35
  • 99.4 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia NPLOC4 36
  • 97 (a)
OneToOne
NPLOC4 35
  • 90.57 (n)
  • 97.2 (a)
dog
(Canis familiaris)
Mammalia NPLOC4 35
  • 90.44 (n)
  • 97.84 (a)
NPLOC4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nploc4 16
Nploc4 36
  • 97 (a)
OneToOne
Nploc4 35
  • 89.04 (n)
  • 97.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NPLOC4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nploc4 35
  • 89.36 (n)
  • 97.04 (a)
chicken
(Gallus gallus)
Aves NPLOC4 36
  • 92 (a)
OneToOne
NPLOC4 35
  • 82.13 (n)
  • 92.43 (a)
lizard
(Anolis carolinensis)
Reptilia NPLOC4 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia npl4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nploc4 35
  • 76.43 (n)
  • 88.08 (a)
zebrafish
(Danio rerio)
Actinopterygii nploc4 35
  • 75.32 (n)
  • 84.46 (a)
wufi11f09 35
nploc4 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001986 35
  • 55.44 (n)
  • 50.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Npl4 36
  • 47 (a)
OneToOne
Npl4 35
  • 55.41 (n)
  • 50.67 (a)
worm
(Caenorhabditis elegans)
Secernentea npl-4.1 36
  • 44 (a)
OneToMany
npl-4.2 36
  • 44 (a)
OneToMany
npl-4.2 35
  • 51.08 (n)
  • 45.77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR211W 35
  • 48.9 (n)
  • 38.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL4 36
  • 34 (a)
OneToOne
NPL4 38
NPL4 35
  • 45.42 (n)
  • 36.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24575g 35
  • 45.63 (n)
  • 36.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02680 35
  • 46.85 (n)
  • 37.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes npl4 35
  • 45.07 (n)
  • 37.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14013 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4296 36
  • 47 (a)
OneToOne
Species with no ortholog for NPLOC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPLOC4 Gene

ENSEMBL:
Gene Tree for NPLOC4 (if available)
TreeFam:
Gene Tree for NPLOC4 (if available)

Paralogs for NPLOC4 Gene

genes like me logo Genes that share paralogs with NPLOC4: view

No data available for Paralogs for NPLOC4 Gene

Variants for NPLOC4 Gene

Sequence variations from dbSNP and Humsavar for NPLOC4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3935539 -- 81,566,285(-) gcgca(A/G)tcttg intron-variant
rs3935543 -- 81,612,848(-) GCCAC(A/G)CTAGT intron-variant
rs3208785 -- 81,558,922(-) GGGGC(C/G)GATGC nc-transcript-variant, utr-variant-3-prime
rs4072446 -- 81,558,802(+) GGGTG(C/T)CTGCC nc-transcript-variant, utr-variant-3-prime
rs4073997 -- 81,559,376(-) TACGG(C/G/T)GCCGT nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for NPLOC4 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909000 CNV Loss 21882294
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3320n71 CNV Loss 21882294
dgv3324n71 CNV Loss 21882294
dgv3329n71 CNV Loss 21882294
dgv3330n71 CNV Loss 21882294
nsv833567 CNV Loss 17160897
nsv833568 CNV Loss 17160897
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv2164 CNV Insertion 18451855
esv1009816 CNV Insertion 20482838
nsv909109 CNV Loss 21882294
esv2667665 CNV Deletion 23128226
esv2666942 CNV Deletion 23128226
esv9166 CNV Loss 19470904
esv2716454 CNV Deletion 23290073
esv1319911 CNV Deletion 17803354
nsv909110 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294

Variation tolerance for NPLOC4 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPLOC4 Gene

HapMap Linkage Disequilibrium report
NPLOC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPLOC4 Gene

Disorders for NPLOC4 Gene

Relevant External Links for NPLOC4

Genetic Association Database (GAD)
NPLOC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPLOC4

No disorders were found for NPLOC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPLOC4 Gene

Publications for NPLOC4 Gene

  1. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PMID: 11574150) Botta A. … Novelli G. (Gene 2001) 2 3 4 23 67
  2. The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. (PMID: 24429874) Riemer A. … Meyer H. (Cell Cycle 2014) 2 3
  3. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. (PMID: 10811609) Meyer H.H. … Warren G. (EMBO J. 2000) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NPLOC4 Gene

Sources for NPLOC4 Gene

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