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Aliases for NPLOC4 Gene

Aliases for NPLOC4 Gene

  • NPL4 Homolog, Ubiquitin Recognition Factor 2 3 5
  • NPLOC4 Ubiquitin Recognition Factor 2 3
  • NPL4 3 4
  • Nuclear Protein Localization 4 Homolog (S. Cerevisiae) 2
  • Nuclear Protein Localization Protein 4 Homolog 3
  • Nuclear Protein Localization 4 Homolog 3
  • Protein NPL4 4
  • KIAA1499 4

External Ids for NPLOC4 Gene

Previous GeneCards Identifiers for NPLOC4 Gene

  • GC17M077135
  • GC17M079523
  • GC17M074971

Summaries for NPLOC4 Gene

GeneCards Summary for NPLOC4 Gene

NPLOC4 (NPL4 Homolog, Ubiquitin Recognition Factor) is a Protein Coding gene. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Protein processing in endoplasmic reticulum. GO annotations related to this gene include ubiquitin protein ligase binding and ubiquitin binding.

UniProtKB/Swiss-Prot for NPLOC4 Gene

  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Wiki entry for NPLOC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPLOC4 Gene

Genomics for NPLOC4 Gene

Regulatory Elements for NPLOC4 Gene

Enhancers for NPLOC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081558 1.1 Ensembl ENCODE 33.5 +84.1 84103 11.1 PKNOX1 SIN3A FEZF1 RAD21 ZNF366 FOS EGR2 ZNF263 SMARCC1 CEBPB NPLOC4 TSPAN10 ARL16 OXLD1 ENSG00000229848 FSCN2 ENSG00000262877 PDE6G CCDC137 GCGR
GH17F081596 1.1 Ensembl ENCODE 31.3 +49.0 49006 5.4 HDGF CTCF SIN3A RAD21 ZNF316 POLR2A EED ZNF143 SMC3 ETV6 TSPAN10 NPLOC4 ARL16 FAAP100 PDE6G OXLD1 CCDC137 TMEM105 OGFOD3 GC17M081598
GH17F082291 1.7 FANTOM5 ENCODE 14.1 -650.2 -650169 14.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 TEX19 CSNK1D ENSG00000262049 HGS SLC16A3 SECTM1 CCDC57 NPLOC4 ACTG1 MIR6787
GH17F082492 1.9 FANTOM5 Ensembl ENCODE 12.4 -847.5 -847540 7.0 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NARF ARL2BPP9 ALYREF ENSG00000262049 OGFOD3 ENSG00000262652 HGS LOC105371942 NARF-IT1 SECTM1
GH17F082095 1.6 FANTOM5 ENCODE 12.5 -453.0 -453012 12.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CCDC57 NPLOC4 LOC105371942 ARL16 ENSG00000262877 TSPAN10 ARL2BPP9 ALYREF ENSG00000262049 CEP131
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPLOC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPLOC4 Gene

Chromosome:
17
Start:
81,556,885 bp from pter
End:
81,648,465 bp from pter
Size:
91,581 bases
Orientation:
Minus strand

Genomic View for NPLOC4 Gene

Genes around NPLOC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPLOC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPLOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPLOC4 Gene

Proteins for NPLOC4 Gene

  • Protein details for NPLOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT6-NPL4_HUMAN
    Recommended name:
    Nuclear protein localization protein 4 homolog
    Protein Accession:
    Q8TAT6
    Secondary Accessions:
    • Q8N3J1
    • Q9H8V2
    • Q9H964
    • Q9NWR5
    • Q9P229

    Protein attributes for NPLOC4 Gene

    Size:
    608 amino acids
    Molecular mass:
    68120 Da
    Quaternary structure:
    • Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.
    SequenceCaution:
    • Sequence=BAA91314.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96023.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14499.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NPLOC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPLOC4 Gene

Post-translational modifications for NPLOC4 Gene

  • Ubiquitination at Lys 62, Lys 68, Lys 116, Lys 189, Lys 207, Lys 243, Lys 260, Lys 302, Lys 307, Lys 404, Lys 431, and Lys 544
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NPLOC4 (NPL4)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NPLOC4

No data available for DME Specific Peptides for NPLOC4 Gene

Domains & Families for NPLOC4 Gene

Gene Families for NPLOC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAT6

UniProtKB/Swiss-Prot:

NPL4_HUMAN :
  • Binds ubiquitinated proteins via its RanBP2-type zinc finger.
  • Belongs to the NPL4 family.
  • Contains 1 RanBP2-type zinc finger.
Domain:
  • Binds ubiquitinated proteins via its RanBP2-type zinc finger.
Family:
  • Belongs to the NPL4 family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with NPLOC4: view

Function for NPLOC4 Gene

Molecular function for NPLOC4 Gene

UniProtKB/Swiss-Prot Function:
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Ontology (GO) - Molecular Function for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574150
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0043130 ubiquitin binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NPLOC4: view
genes like me logo Genes that share phenotypes with NPLOC4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPLOC4 Gene

Localization for NPLOC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPLOC4 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPLOC4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum ISS 11574150
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NPLOC4: view

Pathways & Interactions for NPLOC4 Gene

genes like me logo Genes that share pathways with NPLOC4: view

UniProtKB/Swiss-Prot Q8TAT6-NPL4_HUMAN

  • Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway.

Gene Ontology (GO) - Biological Process for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0007030 Golgi organization ISS 11574150
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process ISS 11574150
GO:0030970 retrograde protein transport, ER to cytosol IMP 25660456
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with NPLOC4: view

No data available for SIGNOR curated interactions for NPLOC4 Gene

Transcripts for NPLOC4 Gene

Unigene Clusters for NPLOC4 Gene

Nuclear protein localization 4 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPLOC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e · 23f · 23g · 23h · 23i
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -

Relevant External Links for NPLOC4 Gene

GeneLoc Exon Structure for
NPLOC4
ECgene alternative splicing isoforms for
NPLOC4

Expression for NPLOC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPLOC4 Gene

mRNA differential expression in normal tissues according to GTEx for NPLOC4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for NPLOC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9) and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPLOC4 Gene



Protein tissue co-expression partners for NPLOC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPLOC4 Gene:

NPLOC4

SOURCE GeneReport for Unigene cluster for NPLOC4 Gene:

Hs.464333

mRNA Expression by UniProt/SwissProt for NPLOC4 Gene:

Q8TAT6-NPL4_HUMAN
Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.
genes like me logo Genes that share expression patterns with NPLOC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NPLOC4 Gene

Orthologs for NPLOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NPLOC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPLOC4 34 35
  • 99.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NPLOC4 34 35
  • 90.57 (n)
dog
(Canis familiaris)
Mammalia NPLOC4 34 35
  • 90.44 (n)
rat
(Rattus norvegicus)
Mammalia Nploc4 34
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Nploc4 34 16 35
  • 89.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPLOC4 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPLOC4 34 35
  • 82.13 (n)
lizard
(Anolis carolinensis)
Reptilia NPLOC4 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nploc4 34
  • 76.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia npl4-prov 34
zebrafish
(Danio rerio)
Actinopterygii nploc4 34 35
  • 75.32 (n)
wufi11f09 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001986 34
  • 55.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Npl4 34 35
  • 55.41 (n)
worm
(Caenorhabditis elegans)
Secernentea npl-4.2 34 35
  • 51.08 (n)
npl-4.1 35
  • 44 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR211W 34
  • 48.9 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24575g 34
  • 45.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL4 34 35 37
  • 45.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4296 35
  • 47 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02680 34
  • 46.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes npl4 34
  • 45.07 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14013 34
Species where no ortholog for NPLOC4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPLOC4 Gene

ENSEMBL:
Gene Tree for NPLOC4 (if available)
TreeFam:
Gene Tree for NPLOC4 (if available)

Paralogs for NPLOC4 Gene

No data available for Paralogs for NPLOC4 Gene

Variants for NPLOC4 Gene

Sequence variations from dbSNP and Humsavar for NPLOC4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10445408 -- 81,562,228(+) ttccg(C/T)ctcaa intron-variant, nc-transcript-variant
rs10534151 -- 81,599,286(+) TCCTC(-/AA)AAAAA intron-variant
rs10588038 -- 81,603,014(+) acaca(C/T)atata intron-variant
rs10599354 -- 81,595,952(+) GTTAA(-/GTT)GTTCA intron-variant
rs10608622 -- 81,606,214(+) AGCCG(-/GCCG)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPLOC4 Gene

Variant ID Type Subtype PubMed ID
dgv1522n106 CNV deletion 24896259
esv1009816 CNV insertion 20482838
esv1319911 CNV deletion 17803354
esv26223 CNV gain+loss 19812545
esv2666942 CNV deletion 23128226
esv2667665 CNV deletion 23128226
esv2716454 CNV deletion 23290073
esv3363550 CNV insertion 20981092
esv3554885 CNV deletion 23714750
esv9166 CNV loss 19470904
nsv1071812 CNV deletion 25765185
nsv1150393 CNV insertion 26484159
nsv2164 CNV insertion 18451855
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv471902 CNV novel sequence insertion 20440878
nsv828128 CNV loss 20364138
nsv833567 CNV loss 17160897
nsv833568 CNV loss 17160897
nsv952389 CNV deletion 24416366
nsv954534 CNV deletion 24416366

Variation tolerance for NPLOC4 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPLOC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPLOC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPLOC4 Gene

Disorders for NPLOC4 Gene

Relevant External Links for NPLOC4

Genetic Association Database (GAD)
NPLOC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPLOC4

No disorders were found for NPLOC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPLOC4 Gene

Publications for NPLOC4 Gene

  1. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PMID: 11574150) Botta A. … Novelli G. (Gene 2001) 2 3 4 22 64
  2. The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. (PMID: 24429874) Riemer A. … Meyer H. (Cell Cycle 2014) 2 3 64
  3. Digital quantification of human eye color highlights genetic association of three new loci. (PMID: 20463881) Liu F. … Kayser M. (PLoS Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NPLOC4 Gene

Sources for NPLOC4 Gene

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