Aliases for NPLOC4 Gene
External Ids for NPLOC4 Gene
Previous GeneCards Identifiers for NPLOC4 Gene
GeneCards Summary for NPLOC4 Gene
NPLOC4 (NPL4 Homolog, Ubiquitin Recognition Factor) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include ubiquitin protein ligase binding and ubiquitin binding.
UniProtKB/Swiss-Prot for NPLOC4 Gene
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).