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Aliases for NPLOC4 Gene

Aliases for NPLOC4 Gene

  • Nuclear Protein Localization 4 Homolog (S. Cerevisiae) 2 3
  • NPL4 3 4 6
  • KIAA1499 4 6
  • Nuclear Protein Localization Protein 4 Homolog 3
  • Protein NPL4 4

External Ids for NPLOC4 Gene

Summaries for NPLOC4 Gene

GeneCards Summary for NPLOC4 Gene

NPLOC4 (Nuclear Protein Localization 4 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF.

UniProtKB/Swiss-Prot for NPLOC4 Gene

  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Wiki entry for NPLOC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPLOC4 Gene

Genomics for NPLOC4 Gene

Genomic Location for NPLOC4 Gene

Start:
81,556,887 bp from pter
End:
81,648,465 bp from pter
Size:
91,579 bases
Orientation:
Minus strand

Genomic View for NPLOC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPLOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPLOC4 Gene

Regulatory Elements for NPLOC4 Gene

Proteins for NPLOC4 Gene

  • Protein details for NPLOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT6-NPL4_HUMAN
    Recommended name:
    Nuclear protein localization protein 4 homolog
    Protein Accession:
    Q8TAT6
    Secondary Accessions:
    • Q8N3J1
    • Q9H8V2
    • Q9H964
    • Q9NWR5
    • Q9P229

    Protein attributes for NPLOC4 Gene

    Size:
    608 amino acids
    Molecular mass:
    68120 Da
    Quaternary structure:
    • Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.
    SequenceCaution:
    • Sequence=BAA91314.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96023.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14499.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NPLOC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPLOC4 Gene

Proteomics data for NPLOC4 Gene at MOPED

Post-translational modifications for NPLOC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62, Lys68, Lys116, Lys189, Lys207, Lys243, Lys260, Lys302, Lys307, Lys404, Lys431, and Lys544

No data available for DME Specific Peptides for NPLOC4 Gene

Domains for NPLOC4 Gene

UniProtKB/Swiss-Prot:

NPL4_HUMAN
Domain:
  • Binds ubiquitinated proteins via its RanBP2-type zinc finger:
    • Q8TAT6
Family:
  • Belongs to the NPL4 family.:
    • Q8TAT6
Similarity:
  • Contains 1 RanBP2-type zinc finger.:
    • Q8TAT6
genes like me logo Genes that share domains with NPLOC4: view

No data available for Gene Families for NPLOC4 Gene

Function for NPLOC4 Gene

Molecular function for NPLOC4 Gene

UniProtKB/Swiss-Prot Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Gene Ontology (GO) - Molecular Function for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11574150
GO:0008270 zinc ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with NPLOC4: view

Phenotypes for NPLOC4 Gene

MGI mutant phenotypes for NPLOC4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPLOC4: view

miRNA for NPLOC4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NPLOC4 Gene

Localization for NPLOC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPLOC4 Gene

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPLOC4 Gene COMPARTMENTS Subcellular localization image for NPLOC4 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
nucleus 2

Gene Ontology (GO) - Cellular Components for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005783 endoplasmic reticulum ISS 11574150
GO:0005829 cytosol IEA --
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network ISS 11574150
genes like me logo Genes that share ontologies with NPLOC4: view

Pathways for NPLOC4 Gene

genes like me logo Genes that share pathways with NPLOC4: view

Pathways by source for NPLOC4 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for NPLOC4 Gene
1 KEGG pathway for NPLOC4 Gene

UniProtKB/Swiss-Prot Q8TAT6-NPL4_HUMAN

  • Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway

Gene Ontology (GO) - Biological Process for NPLOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0007030 Golgi organization ISS 11574150
GO:0019985 translesion synthesis TAS --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process ISS 11574150
genes like me logo Genes that share ontologies with NPLOC4: view

Transcripts for NPLOC4 Gene

Unigene Clusters for NPLOC4 Gene

Nuclear protein localization 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPLOC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e · 23f · 23g · 23h · 23i
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7: -
SP8: -
SP9: -
SP10: -

Relevant External Links for NPLOC4 Gene

GeneLoc Exon Structure for
NPLOC4
ECgene alternative splicing isoforms for
NPLOC4

Expression for NPLOC4 Gene

mRNA expression in normal human tissues for NPLOC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPLOC4 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPLOC4 Gene

SOURCE GeneReport for Unigene cluster for NPLOC4 Gene Hs.464333

mRNA Expression by UniProt/SwissProt for NPLOC4 Gene

Q8TAT6-NPL4_HUMAN
Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.
genes like me logo Genes that share expressions with NPLOC4: view

Orthologs for NPLOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NPLOC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPLOC4 36
  • 99.4 (n)
  • 99.84 (a)
NPLOC4 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPLOC4 36
  • 90.57 (n)
  • 97.2 (a)
NPLOC4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPLOC4 36
  • 90.44 (n)
  • 97.84 (a)
NPLOC4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nploc4 36
  • 89.04 (n)
  • 97.37 (a)
Nploc4 16
Nploc4 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NPLOC4 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nploc4 36
  • 89.36 (n)
  • 97.04 (a)
chicken
(Gallus gallus)
Aves NPLOC4 36
  • 82.13 (n)
  • 92.43 (a)
NPLOC4 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPLOC4 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia npl4-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nploc4 36
  • 76.43 (n)
  • 88.08 (a)
zebrafish
(Danio rerio)
Actinopterygii nploc4 36
  • 75.32 (n)
  • 84.46 (a)
nploc4 37
  • 81 (a)
OneToOne
wufi11f09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001986 36
  • 55.44 (n)
  • 50.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Npl4 36
  • 55.41 (n)
  • 50.67 (a)
Npl4 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npl-4.1 37
  • 44 (a)
OneToMany
npl-4.2 36
  • 51.08 (n)
  • 45.77 (a)
npl-4.2 37
  • 44 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR211W 36
  • 48.9 (n)
  • 38.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL4 36
  • 45.42 (n)
  • 36.61 (a)
NPL4 37
  • 34 (a)
OneToOne
NPL4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24575g 36
  • 45.63 (n)
  • 36.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02680 36
  • 46.85 (n)
  • 37.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes npl4 36
  • 45.07 (n)
  • 37.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14013 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4296 37
  • 47 (a)
OneToOne
Species with no ortholog for NPLOC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPLOC4 Gene

ENSEMBL:
Gene Tree for NPLOC4 (if available)
TreeFam:
Gene Tree for NPLOC4 (if available)

Paralogs for NPLOC4 Gene

genes like me logo Genes that share paralogs with NPLOC4: view

No data available for Paralogs for NPLOC4 Gene

Variants for NPLOC4 Gene

Sequence variations from dbSNP and Humsavar for NPLOC4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1106361 -- 81,571,279(-) AAAGC(A/G)GACGG intron-variant
rs1122424 -- 81,593,468(+) ttccc(C/T)tgatg intron-variant
rs3208785 -- 81,558,922(-) GGGGC(C/G)GATGC utr-variant-3-prime
rs3208787 -- 81,558,634(-) TATAA(C/T)AACAG utr-variant-3-prime
rs3922945 -- 81,569,296(+) TTGGA(A/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPLOC4 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909000 CNV Loss 21882294
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3320n71 CNV Loss 21882294
dgv3324n71 CNV Loss 21882294
dgv3329n71 CNV Loss 21882294
dgv3330n71 CNV Loss 21882294
nsv833567 CNV Loss 17160897
nsv833568 CNV Loss 17160897
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv2164 CNV Insertion 18451855
esv1009816 CNV Insertion 20482838
nsv909109 CNV Loss 21882294
esv2667665 CNV Deletion 23128226
esv2666942 CNV Deletion 23128226
esv9166 CNV Loss 19470904
esv2716454 CNV Deletion 23290073
esv1319911 CNV Deletion 17803354
nsv909110 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294

Relevant External Links for NPLOC4 Gene

HapMap Linkage Disequilibrium report
NPLOC4

Disorders for NPLOC4 Gene

Relevant External Links for NPLOC4

Genetic Association Database (GAD)
NPLOC4
genes like me logo Genes that share disorders with NPLOC4: view

No data available for UniProtKB/Swiss-Prot for NPLOC4 Gene

Publications for NPLOC4 Gene

  1. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PMID: 11574150) Botta A. … Novelli G. (Gene 2001) 2 3 4 23
  2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. (PMID: 10811609) Meyer H.H. … Warren G. (EMBO J. 2000) 2 3
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for NPLOC4 Gene

Sources for NPLOC4 Gene

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