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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPLOC4 Gene

protein-coding   GIFtS: 55
GCID: GC17M079523

nuclear protein localization 4 homolog (S. cerevisiae)
 Explore 5 diseases affiliated with
NPLOC4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPLOC4    

Aliases
for NPLOC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Protein Localization 4 Homolog (S. Cerevisiae)1 2
NPL41 2 3 5
KIAA14991 3 5
FLJ206571
Nuclear Protein Localization Protein 4 Homolog2
Protein NPL43

External Ids:    HGNC: 182611   Entrez Gene: 556662   Ensembl: ENSG000001824467   OMIM: 6065905   UniProtKB: Q8TAT63   

Export aliases for NPLOC4 gene to outside databases

Previous GC identifers: GC17M077135 GC17M074971


Summaries
for NPLOC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a
closed nuclear envelope (By similarity)

Gene Wiki entry for NPLOC4


Genomic Views
for NPLOC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPLOC4 gene promoter:
         GCNF-1   GCNF   STAT5A   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPLOC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPLOC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPLOC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17qter   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NPLOC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPLOC4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079523:  view genomic region     (about GC identifiers)

Start:
 79,523,913 bp from pter      End:
 79,615,495 bp from pter
Size:
 91,583 bases      Orientation:
 minus strand

Proteins
for NPLOC4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6 (See protein sequence)
Recommended Name: Nuclear protein localization protein 4 homolog  
Size: 608 amino acids; 68120 Da
Subunit: Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and
inhibits Golgi membrane fusion
Subcellular location: Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By
similarity). Note=Associated with the endoplasmic reticulum and nuclear (By similarity)
Sequence caution: Sequence=BAA91314.1; Type=Erroneous initiation; Sequence=BAA96023.1; Type=Erroneous initiation;
Sequence=BAB14372.1; Type=Erroneous initiation; Sequence=BAB14499.1; Type=Erroneous initiation;
Secondary accessions: Q8N3J1 Q9H8V2 Q9H964 Q9NWR5 Q9P229
Alternative splicing: 2 isoforms:  Q8TAT6-1   Q8TAT6-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPLOC4: NX_Q8TAT6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAT6

    • NPLOC4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060391.2  
    ENSEMBL proteins: 
     ENSP00000331487   ENSP00000467400   ENSP00000459457   ENSP00000465247   ENSP00000460465  
     ENSP00000458384   ENSP00000459462   ENSP00000363879   ENSP00000461543   ENSP00000461478  
     ENSP00000446199  

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    Novus Biologicals NPLOC4 Proteins
    Novus Biologicals NPLOC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NPLOC4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ISS11574150
    GO:0005829cytosol IEA--
    GO:0042175nuclear outer membrane-endoplasmic reticulum membrane network ISS11574150


    NPLOC4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NPLOC4

    Protein Domains /
    Families
    for NPLOC4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPLOC4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR024682 Npl4_Ub-like_dom
     IPR007717 NPL4
     IPR001876 Znf_RanBP2
     IPR016563 PolyUb_recognition_cplx_Npl4
     IPR007716 NPL4_Zn-bd_put

    Graphical View of Domain Structure for InterPro Entry Q8TAT6

    ProtoNet protein and cluster: Q8TAT6

    1 Blocks protein family: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Domain: Binds ubiquitinated proteins via its RanBP2-type zinc finger
    Similarity: Belongs to the NPL4 family
    Similarity: Contains 1 RanBP2-type zinc finger


    Function
    for NPLOC4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Function: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
    export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
    NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a
    closed nuclear envelope (By similarity)

    miRNA
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    hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmid: NPLOC4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11574150
    GO:0008270zinc ion binding IEA--


    NPLOC4 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nploc4):
     mortality/aging 

    NPLOC4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NPLOC4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of degradation of wt-CFTR
    		Regulation of degradation of wt-CFTR1.00
    		Regulation of degradation of deltaF508 CFTR in CF0.59
    2Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for NPLOC4
        Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR


    1         Kegg Pathway  (Kegg details for NPLOC4):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway


    NPLOC4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPLOC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for NPLOC4 (Q8TAT62, 3 ENSP000003314874) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550722, 3, ENSP000003517774MINT-7903922 MINT-7903948 MINT-7903973 I2D: score=9 STRING: ENSP00000351777
    NSFL1CQ9UNZ22, 3, ENSP000002168794MINT-7903948 MINT-7903973 I2D: score=2 STRING: ENSP00000216879
    UFD1LQ928902, 3, ENSP000002632024MINT-7903922 MINT-7903948 I2D: score=19 STRING: ENSP00000263202
    UBCP0CG482, 3, ENSP000003448184MINT-3973725 I2D: score=4 STRING: ENSP00000344818
    UBE4BO951553, ENSP000003430014I2D: score=4 STRING: ENSP00000343001
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006944cellular membrane fusion ISS11574150
    GO:0007030Golgi organization ISS11574150
    GO:0030433ER-associated protein catabolic process ISS11574150


    NPLOC4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPLOC4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPLOC4
    Search CenterWatch for drugs/clinical trials and news about NPLOC4 / NPL4 

    Transcripts
    for NPLOC4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPLOC4 gene: 
    NM_017921.2  

    Unigene Cluster for NPLOC4:

    Nuclear protein localization 4 homolog (S. cerevisiae)
    Hs.464333  [show with all ESTs]
    Unigene Representative Sequence: AK024398
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000331134(uc002kar.3 uc010dic.3 uc002kas.3 uc002kat.4)
    ENST00000572760 ENST00000574964 ENST00000572346 ENST00000573519 ENST00000573876
    ENST00000571714 ENST00000572824 ENST00000573212 ENST00000374747(uc002kau.3 uc010wur.1)
    ENST00000576940 ENST00000574897 ENST00000576713 ENST00000572351 ENST00000570324
    ENST00000573328 ENST00000574344 ENST00000570300

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NPLOC4 (see all 32):
    hsa-miR-4328 hsa-miR-106a hsa-miR-519a hsa-miR-9 hsa-miR-124 hsa-miR-93 hsa-miR-506 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmid: NPLOC4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB040932.1 AF086475.1 AK000664.1 AK023046.1 AK023272.1 AK024398.1 AK074322.1 AK294473.1 
    AK311741.1 AL133629.1 AL834300.1 BC013406.2 BC025930.1 

    19 DOTS entries:

    DT.455631  DT.100655372  DT.92450457  DT.100655369  DT.92450459  DT.100044800  DT.120958182  DT.40122399 
    DT.95265878  DT.120958195  DT.40189079  DT.120958162  DT.75116078  DT.120958196  DT.120958206  DT.75151602 
    DT.40260067  DT.97774580  DT.99962343 

    24/448 AceView cDNA sequences (see all 448):

    AK023272 F36694 BU538380 AA614854 CB146796 BF116210 AA830200 BQ900286 
    AI498719 BE676303 BQ944031 BQ671479 W84895 AI095487 BI192959 BQ226757 
    AW193587 AI826643 BM705108 AU118387 AW247178 BX115626 AI955240 BM799606 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NPLOC4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^
    SP1:                                                                    -     -                                   -     -     -                 -     -     -   
    SP2:                                                                                                              -     -     -                 -     -     -   
    SP3:                                                                                                              -     -     -                 -     -     -   
    SP4:                                                                          -                                   -     -     -                                 
    SP5:                                                                                                              -     -     -                 -           -   

    ExUns: 22 ^ 23a · 23b · 23c · 23d · 23e · 23f · 23g · 23h · 23i
    SP1:  -                                                         
    SP2:  -                                                         
    SP3:                                                            
    SP4:                                                            
    SP5:  -                                                         


    ECgene alternative splicing isoforms for NPLOC4

    Expression
    for NPLOC4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPLOC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTACCAGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NPLOC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPLOC4

    SOURCE GeneReport for Unigene cluster: Hs.464333

    UniProtKB/Swiss-Prot: NPL4_HUMAN, Q8TAT6
    Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including NPLOC4: 
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    In Situ
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    Orthologs
    for NPLOC4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NPLOC4 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nploc41 , 5 nuclear protein localization 4 homolog (S. cerevisiae)1, 5 89.04(n)1
    97.37(a)1    		   11 (84.09 cM)5
    2173651  NM_001195023.11  NP_001181952.11 
     1203803705 
    chicken
    (Gallus gallus)    		 Aves NPLOC41 nuclear protein localization 4 homolog (S. cerevisiae) 82.13(n)
    92.43(a)    		   417456  XM_415704.3  XP_415704.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NPLOC46
    		 --
    		 90(a)
    		 1 ↔ 1
    		 2(98526939-98579089)
    African clawed frog
    (Xenopus laevis)    		 Amphibia npl4-prov2 homolog of yeast nuclear protein localization 4 76.76(n)    BC056013.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi11f092 wufi11f09 78.56(n)   327447  BC045845.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG46731 CG4673 55.35(n)
    50.67(a)    		   43091  NM_001170260.1  NP_001163731.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea npl-4.21 Protein NPL-4.2 51.08(n)
    45.77(a)    		   3565577  NM_062692.2  NP_495093.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes NPL4(YBR170C)4
    NPL41    		 Ubiquitin-binding protein involved in protein degradation; more4
    Npl4p1    		 45.36(n)1
    36.61(a)1    		   2(578086-576344)4
    8524681, 4  NP_009729.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G479706
    NPL416
    		 NPL4-like protein 2
    nuclear protein localization protein 4-like protei...
    		 26(a)
    25(a)
    		 many → 1
    many → 1
    		 2(19629474-19631182)
    3(23283609-23285540)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 NPL4, putative, expressed
    		 23(a)
    		 1 ↔ 1
    		 1(15643786-15648494)


    ENSEMBL Gene Tree for NPLOC4 (if available)
    TreeFam Gene Tree for NPLOC4 (if available) 

    Paralogs
    for NPLOC4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NPLOC4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/50 NCBI SNPs in NPLOC4 are shown (see all 50)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1902941861,2
    		--79527184(+) CACGCC/TTGTAA 1 -- int10--------
    rs2006549201,2
    		--79572318(+) AAAAA-/ATAAATA 1 -- int10--------
    rs2014669361,2
    		--79572319(+) AAAAA-/TAAATA 1 -- int10--------
    rs1124177251,2
    		C,--79578219(+) CAAGCA/GCCTGT 1 -- int13Minor allele frequency- G:0.47WA NA EA 242
    rs1123642541,2
    		C,--79578287(+) GTTGCG/AATGAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1822547661,2
    		--79578639(+) CCAAAA/GTGCTG 1 -- int10--------
    rs1114941131,2
    		C,--79578655(+) ACAGGC/TGTGAG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1115821651,2
    		C,--79578668(+) ACTGCG/ACCTGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1872620501,2
    		--79578725(+) TTGCGC/TCCTGT 1 -- int10--------
    rs1456401151,2
    		C,--79578759(+) AGGCGG/TGTGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NPLOC4 (79523913 - 79615495 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for NPLOC4
         6 CNVs: 73071 5040 30034 35515 5039 23536
         1 Indel: 61591

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NPLOC4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPLOC4 for disorders           About GeneDecksing

    OMIM gene information: 606590    OMIM disorders: --

    5 diseases for NPLOC4:    About MalaCards
    nevoid basal cell carcinoma syndrome    basal cell carcinoma    cholera    malaria
    carcinoma


    Export disorders for NPLOC4 gene to outside databases

    Publications
    for NPLOC4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPLOC4 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with NPLOC4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). (PubMed id 11574150)1, 2, 3, 9 Botta A....Novelli G. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. A complex of mammalian ufd1 and npl4 links the AAA-AT Pase, p97, to ubiquitin and nuclear transport pathways. (PubMed id 10811609)1, 3 Meyer H.H....Warren G. (2000)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)1 Haines D.S....Deshaies R.J. (2012)
    10. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. (PubMed id 23042607)1 Davis E.J....Rouse J. (2012)

    External Searches for NPLOC4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NPLOC4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55666 HGNC: 18261 AceView: NPL4 Ensembl:ENSG00000182446 euGenes: HUgn55666
    ECgene: NPLOC4 Kegg: 55666 H-InvDB: NPLOC4

    Other Databases showing NPLOC4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1499

    Specialized Databases showing NPLOC4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPLOC4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPLOC4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPLOC4 gene:
    Search GeneIP for patents involving NPLOC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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