NPIPL3 Gene
protein-coding GIFtS: 37
GCID: GC16M021413
|
|
nuclear pore complex interacting protein-like 3
| |
Aliases
for NPIPL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Pore Complex Interacting Protein-Like 31 2 | | KIAA0220-Like Protein2 | | KIAA02201 3 | | Nuclear Pore Complex-Interacting Protein-Like 32 | | Protein Pps22-12 3 | | PI-3-Kinase-Related Kinase SMG-1 Isoform 1 Homolog2 | | KIAA0220L2 | | |
Export aliases for NPIPL3 gene to outside databasesPrevious GC identifer: GC16M021322 |
Summaries
for NPIPL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NPIPL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPIPL3 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx2-2 Nkx3-1 v1 HNF-1A Nkx3-1 v2 MEF-2A HNF-1 Nkx3-1 v3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPIPL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIPL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.2 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12.2NPIPL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M021413: view genomic region
(about GC identifiers)
Start:
|
21,413,455 bp from pter |
End:
|
21,459,888 bp from pter |
Size:
|
46,434 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr16- 21,845,890-21,892,148 |
|
Proteins
for NPIPL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPPL3_HUMAN, Q92617 (See
protein sequence)Recommended Name: Nuclear pore complex-interacting protein-like 3 Size: 1050 amino acids; 116847 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA13210.2; Type=Frameshift; Positions=203; Sequence=BAD92869.1; Type=Erroneous initiation;
Secondary accessions: O43332 Q504Q6 Q59F29 Q6GMR1 Q6P7T2 Q6PIE2 Q6RH21Alternative splicing: 6 isoforms: Q92617-1 Q92617-2 Q92617-3 Q92617-4 Q92617-5 Q92617-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NPIPL3: NX_Q92617
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92617
NPIPL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_569731.2
ENSEMBL proteins: ENSP00000446048 ENSP00000413141 ENSP00000436028 ENSP00000439062 ENSP00000390496 ENSP00000442633 ENSP00000346048 ENSP00000399107 ENSP00000444096
Human Recombinant Protein Products for NPIPL3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
NPIPL3 for ontologies About GeneDecksing
NPIPL3 Antibody Products:
Assay Products for NPIPL3: |
Protein
Domains /
Families
for NPIPL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPIPL3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92617ProtoNet protein and cluster: Q92617 UniProtKB/Swiss-Prot: NPPL3_HUMAN, Q92617Similarity: Belongs to the NPIP family |
Function
for NPIPL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
NPIPL3 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPIPL3 (NM_130464) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPIPL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIPL3 |
|
Pathways & Interactions
for NPIPL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPIPL3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
NPIPL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NPIPL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPIPL3
Search CenterWatch for drugs/clinical trials and news about NPIPL3 / NPPL3
|
Transcripts
for NPIPL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPIPL3 gene: NM_130464.2 Unigene Clusters for NPIPL3: Nuclear pore complex interacting protein-like 3 Hs.611072 [show with all ESTs], Hs.632865 [show with all ESTs], Hs.720286 [show with all ESTs]Unigene Representative Sequences: AK295170, NM_130464, AB20963217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504841 ENST00000419180 ENST00000542953 ENST00000519305 ENST00000521589
ENST00000534903 ENST00000538439 ENST00000545358 ENST00000535190 ENST00000537983
ENST00000543368 ENST00000544154 ENST00000448012 ENST00000447737(uc010bwu.1 uc021tei.1)
ENST00000319334 ENST00000458643(uc021tem.1 uc002dix.1) ENST00000542817
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPIPL3 (NM_130464) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPIPL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIPL3 |
Additional cDNA sequence: AB209632.1 AK293635.1 AK296338.1 AK303264.1 AK303572.1 AK316332.1 AL049250.1 BC036263.1 BC061522.1 BC073943.1 BC094882.1 24/137 DOTS entries (see all 137): DT.100892100 DT.120695942 DT.95191520 DT.120696725 DT.100892077 DT.87018127 DT.40121581 DT.100892073 DT.120658484 DT.100892093 DT.120658258 DT.97858447 DT.100892079 DT.100059652 DT.97786578 DT.120726572 DT.120697721 DT.100892067 DT.100053074 DT.120726579 DT.100016052 DT.102841573 DT.120658904 DT.91756646 24/164 AceView cDNA sequences (see all 164): AA553378 BM982433 BE182912 BF877036 AI473809 BQ721066 AI583979 AI925076 BU688923 BM773058 AI275966 AI355358 AI357380 AA983637 CA748960 AI707539 AW168517 BM557638 AI418953 AI075022 CA412409 CA438242 BU732827 AI470738
GeneLoc Exon Structure
|
Expression
for NPIPL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPIPL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAATCAA
About this image
See NPIPL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPIPL3
SOURCE GeneReport for Unigene clusters: Hs.611072 Hs.632865 Hs.720286
SABiosciences Custom PCR Arrays for NPIPL3
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NPIPL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPIPL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIPL3 |
Orthologs
for NPIPL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NPIPL3 (if available)
TreeFam Gene Tree for NPIPL3 (if available) |
Paralogs
for NPIPL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NPIPL3 gene
- LOC7288881 2 61E3.41 2 LOC100132247 LOC4403532 ENSG000001980642 LOC7287412 ENSG000002149402 NPIPL12
- PKD1P12 NPIPL22 LOC6427992 LOC1002883322 NPIP2 ENSG000002149672 LOC1005076072 ENSG000002262322
- LOC7299782 LOC6427782 LOC7301532 ENSG000001969932 LOC6130372
17 SIMAP similar genes for NPIPL3 using alignment to 18 protein entries: NPPL3_HUMAN (see all proteins):A-575C2.4 61E3.4 NPIPL1 LOC728888 LOC728734 ACSM3
ACSM2B NPIPP1 NPIPL2 A-761H5.4 LOC728741 Nbla00537
LOC642778 NPIP A-589H1.1 LOC339047 PKD1P1
NPIPL3 for paralogs About GeneDecksing
5/12 Pseudogenes.org Pseudogenes for NPIPL3 (see all 12)
PGOHUM00000256603 PGOHUM00000259011 PGOHUM00000259013 PGOHUM00000259018 PGOHUM00000259030
|
Genomic Variants
for NPIPL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPIPL3 (21413455 - 21459888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 26 variations for NPIPL3
15/21 CNVs (see all 21): 30764 23249 2207 30757 30758 4933 37557 3115 0793 3995 37556 4932 3114 72503 37630
5 Inversions: 37178 0481 29493 29492 0482 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPIPL3 |
|
Disorders
/ Diseases
for NPIPL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for NPIPL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPIPL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NPIPL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PubMed id 11948212)1, 3 Eichler E.E.... Rocchi M. (2001)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for NPIPL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPIPL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPIPL3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NPIPL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPIPL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPIPL3 gene:
Search GeneIP for patents involving NPIPL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPIPL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPIPL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPIPL3 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPIPL3 | | OriGene 3'-UTR Clone for NPIPL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIPL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPIPL3 | | OriGene Custom Protein Services for NPIPL3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPIPL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPIPL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIPL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPIPL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIPL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPIPL3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NPIPL3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NPIPL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for NPIPL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIPL3 |
| |  | |
|
|
|
