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NPIPB9 Gene

protein-coding   GIFtS: 20
GCID: GC16P028783

Nuclear Pore Complex Interacting Protein Family, Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Pore Complex Interacting Protein Family, Member B91 2
Nuclear Pore Complex-Interacting Protein Family Member B92

External Ids:    HGNC: 419871   Entrez Gene: 1005076072   Ensembl: ENSG000001969937   UniProtKB: F8W1W93   

Export aliases for NPIPB9 gene to outside databases

Previous GC identifer: GC16P028782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPIPB9 Gene:
NPIPB9 (nuclear pore complex interacting protein family, member B9) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NPIPB9
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NPIPB9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPIPB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

NPIPB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPB9 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028783:  view genomic region     (about GC identifiers)

Start:
28,761,770 bp from pter      End:
28,784,128 bp from pter
Size:
22,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NPIB9_HUMAN, F8W1W9 (See protein sequence)
Recommended Name: Nuclear pore complex-interacting protein family member B9  
Size: 429 amino acids; 49181 Da

Explore the universe of human proteins at neXtProt for NPIPB9: NX_F8W1W9

Explore proteomics data for NPIPB9 at MOPED


See NPIPB9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001274179.1  NP_001274180.1  

ENSEMBL proteins: 
 ENSP00000350444   ENSP00000446902   ENSP00000415207  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009443 NPIP

Graphical View of Domain Structure for InterPro Entry F8W1W9

ProtoNet protein and cluster: F8W1W9

UniProtKB/Swiss-Prot: NPIB9_HUMAN, F8W1W9
Similarity: Belongs to the NPIP family


Find genes that share domains with NPIPB9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NPIPB9

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPIPB9
Interactions:

    Search GeneGlobe Interaction Network for NPIPB9

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NPIPB9 (ENSP000003504444) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CCSENSP000003078704STRING: ENSP00000307870
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NPIPB9 (NPIB9)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NPIPB9 gene (2 alternative transcripts): 
NM_001287250.1  NM_001287251.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000357796(uc010byk.3 uc010vda.2) ENST00000550983(uc010vcz.2)
ENST00000435324(uc002dqw.2)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

NPIPB9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NPIPB9 Protein Expression
    Custom PCR Arrays for NPIPB9
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB9 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia --
--
(see all 5)
Uncharacterized protein
(see all 5)
92(a)
91(a)
(see all 5)
many ↔ many
many ↔ many
(see all 5)
GL392457.1(96835-111594)
GL392482.1(16432-16992)


ENSEMBL Gene Tree for NPIPB9 (if available)
TreeFam Gene Tree for NPIPB9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NPIPB9 gene
NPIPB81 2  NPIPB61 2  NPIPB151 2  LOC4403532  NPIPA12  NPIPA52  NPIPA22  PKD1P12  
ENSG000002330242  NPIPB32  NPIPA32  NPIPA72  LOC1019299102  LOC7299782  NPIPB52  LOC7301532  
NPIPB112  NPIPB42  NPIPB72  NPIPA82  
Selected SIMAP similar genes for NPIPB9 using alignment to 3 protein entries:     NPIB9_HUMAN (see all proteins) (see all similar genes):
A-575C2.4    LOC728741    A-761H5.4    NPIPB7    NPIPB8    NPIPB15
NPIPB6    NPIPB3    NPIPB11    NPIPB5    NPIPB4    LOC101929910
NPIPA7    NPIPA8    NPIPA3    Nbla00537    NPIPA2    NPIPA5

Find genes that share paralogs with NPIPB9           About GenesLikeMe


5 Pseudogenes.org Pseudogenes for NPIPB9
PGOHUM00000261202 PGOHUM00000261203 PGOHUM00000261205 PGOHUM00000261220 PGOHUM00000261221


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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9 SNPs for NPIPB9    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1491351411,2
--28761431(+) CACCTC/GCTGCT 1 -- us2k10--------
rs3726853691,2
----28777043(+) CATTC-/TGTGTGTGT
GTGTGTGTGTG
GTGTG
1 -- int10--------
rs3762065851,2
----28770171(+) CAGGC-/TTGTAA 1 -- int10--------
rs3744560961,2
----28770144(+) GTCACA/GGGCAT 1 -- int10--------
rs39866761,2
----28767533(+) ttttt-/TTCTT 
        
ntttg
1 -- int10--------
rs2003074851,2
----28763732(+) TTTTT-/TTAAATT 1 -- int10--------
rs2336401,2
----28777093(-) ctgtcA/Tcacac 1 -- int10--------
rs3688472321,2
----28760900(+) GGTTTC/TCCATG 1 -- us2k10--------
rs3741658501,2
----28774238(+) GATGGC/TGATGC 1 -- int10--------

HapMap Linkage Disequilibrium report for NPIPB9 (28761770 - 28784128 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NPIPB9: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NPIPB9
DNA2.0 Custom Variant and Variant Library Synthesis for NPIPB9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NPIPB9 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NPIPB9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100507607 HGNC: 41987 Ensembl:ENSG00000196993 euGenes: HUgn100507607 ECgene: NPIPB9
H-InvDB: NPIPB9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NPIPB9 gene:
Search GeneIP for patents involving NPIPB9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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